TY  - CONF
AU  - Milošević, Maja
AU  - Drakulić, Dunja R.
AU  - Petrović, Snježana
AU  - Stanojević, Ivana
AU  - Veličković, Nataša
AU  - Horvat, Anica
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9319
AB  - L-cysteine is used as effective oral chelating agent due to property of its sulfhydryl
group to bind heavy metal ions. The aim of this study was to investigate ability of
L-cysteine to prevent mercury (II) and cadmium (II) induced ecto-ATPase activity
inhibition of rat uterus plasma membranes. Results show that 10 mmol/l L-cysteine
have protective effect on enzyme activity in the presence of cadmium and mercury
ions.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - L-cysteine modulates the ecto-atpase activity inhibition in presence of cadmium (ii) and mercury (ii) ions
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9319
ER  - 

@conference{
author = "Milošević, Maja and Drakulić, Dunja R. and Petrović, Snježana and Stanojević, Ivana and Veličković, Nataša and Horvat, Anica",
year = "2010",
abstract = "L-cysteine is used as effective oral chelating agent due to property of its sulfhydryl
group to bind heavy metal ions. The aim of this study was to investigate ability of
L-cysteine to prevent mercury (II) and cadmium (II) induced ecto-ATPase activity
inhibition of rat uterus plasma membranes. Results show that 10 mmol/l L-cysteine
have protective effect on enzyme activity in the presence of cadmium and mercury
ions.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "L-cysteine modulates the ecto-atpase activity inhibition in presence of cadmium (ii) and mercury (ii) ions",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9319"
}

Milošević, M., Drakulić, D. R., Petrović, S., Stanojević, I., Veličković, N.,& Horvat, A.. (2010). L-cysteine modulates the ecto-atpase activity inhibition in presence of cadmium (ii) and mercury (ii) ions. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9319

Milošević M, Drakulić DR, Petrović S, Stanojević I, Veličković N, Horvat A. L-cysteine modulates the ecto-atpase activity inhibition in presence of cadmium (ii) and mercury (ii) ions. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9319 .

Milošević, Maja, Drakulić, Dunja R., Petrović, Snježana, Stanojević, Ivana, Veličković, Nataša, Horvat, Anica, "L-cysteine modulates the ecto-atpase activity inhibition in presence of cadmium (ii) and mercury (ii) ions" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9319 .

TY  - CONF
AU  - Petrović, Snježana
AU  - Milošević, Maja
AU  - Stanojević, Ivana
AU  - Drakulić, Dunja R.
AU  - Jovanović, N.
AU  - Veličković, Nataša
AU  - Horvat, Anica
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9321
AB  - In this study the Ca2+ ion flux modulation in the synaptosomal mitochondria
isolated from caudate nucleus (CN) of the ovariectomised rats was examined.
17 beta-estradiol (E2), E2-conjugated to bovine serum albumin (E-BSA), estradiol
receptor α (ERα) agonist 4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol
(PPT), ERβ agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DNP) and ERα/β
antagonist 7α,17β-[9[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-
triene-3,17-diol (ICI 182,780) were used. The Ca2+ efflux inhibition of about 27%
was detected in the presence of 0.5 nmol/l E2, and of about 20% in the case of
E-BSA. DNP (10 nmol/l) was as much potent Ca2+ efflux inhibitor as E2, while
PPT (10 nmol/l) hardly had any inhibitory effect (9% efflux decrease). When E2
binding to ERα and ERβ was prevented by 1 μmol/l ICI 182,780, the Ca2+ efflux
inhibition of about 15% was detected. Our results suggest that E2 prevents Ca2+
efflux from synaptosomal mitochondria due to ERβ activation rather than ERα.
The involvement of the external E2 binding site on the mitochondrial membrane
probably different from ERα/β should not be excluded because of Ca2+ efflux
inhibition detected in the presence of E-BSA and ICI 182,780. The Ca2+ efflux
modulation could be the mechanism through which E2 exerts its neuromodulatory
role in specific brain structures.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Na+-dependent Ca2+ ion flux inhibition by 17 beta-estradiol in caudate nucleus mitochondria
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9321
ER  - 

@conference{
author = "Petrović, Snježana and Milošević, Maja and Stanojević, Ivana and Drakulić, Dunja R. and Jovanović, N. and Veličković, Nataša and Horvat, Anica",
year = "2010",
abstract = "In this study the Ca2+ ion flux modulation in the synaptosomal mitochondria
isolated from caudate nucleus (CN) of the ovariectomised rats was examined.
17 beta-estradiol (E2), E2-conjugated to bovine serum albumin (E-BSA), estradiol
receptor α (ERα) agonist 4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol
(PPT), ERβ agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DNP) and ERα/β
antagonist 7α,17β-[9[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-
triene-3,17-diol (ICI 182,780) were used. The Ca2+ efflux inhibition of about 27%
was detected in the presence of 0.5 nmol/l E2, and of about 20% in the case of
E-BSA. DNP (10 nmol/l) was as much potent Ca2+ efflux inhibitor as E2, while
PPT (10 nmol/l) hardly had any inhibitory effect (9% efflux decrease). When E2
binding to ERα and ERβ was prevented by 1 μmol/l ICI 182,780, the Ca2+ efflux
inhibition of about 15% was detected. Our results suggest that E2 prevents Ca2+
efflux from synaptosomal mitochondria due to ERβ activation rather than ERα.
The involvement of the external E2 binding site on the mitochondrial membrane
probably different from ERα/β should not be excluded because of Ca2+ efflux
inhibition detected in the presence of E-BSA and ICI 182,780. The Ca2+ efflux
modulation could be the mechanism through which E2 exerts its neuromodulatory
role in specific brain structures.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Na+-dependent Ca2+ ion flux inhibition by 17 beta-estradiol in caudate nucleus mitochondria",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9321"
}

Petrović, S., Milošević, M., Stanojević, I., Drakulić, D. R., Jovanović, N., Veličković, N.,& Horvat, A.. (2010). Na+-dependent Ca2+ ion flux inhibition by 17 beta-estradiol in caudate nucleus mitochondria. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9321

Petrović S, Milošević M, Stanojević I, Drakulić DR, Jovanović N, Veličković N, Horvat A. Na+-dependent Ca2+ ion flux inhibition by 17 beta-estradiol in caudate nucleus mitochondria. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9321 .

Petrović, Snježana, Milošević, Maja, Stanojević, Ivana, Drakulić, Dunja R., Jovanović, N., Veličković, Nataša, Horvat, Anica, "Na+-dependent Ca2+ ion flux inhibition by 17 beta-estradiol in caudate nucleus mitochondria" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9321 .

TY  - CONF
AU  - Stanojević, Ivana
AU  - Milošević, Maja
AU  - Petrović, Snježana
AU  - Drakulić, Dunja R.
AU  - Veličković, Nataša
AU  - Horvat, Anica
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9324
AB  - Kinetic properties of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases)
in synaptic terminals from whole rat brain were characterised. Three different
NTPDases are present in nervous system and hydrolysing ATP and ADP with
different affinities. ATP and ADP hydrolysis exhibited kinetic properties typical
for all members of the NTPDase, low substrate specificity for tri- and
diphosphonucleosides, divalent cation dependency and insensitivity towards iontransporting
ATPase inhibitors. Kinetic properties of ATPase and ADPase
component of NTPDases depend on postnatal developmental stages of rats, and
indicated different NTPDase family members present in various ontogeny stages.
Lowering in the NTPDases activities could result in a decreased production of
adenosine and change in extracellular ATP/adenosine ratio.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Kinetic properties of ntpdases in rat brain synaptic plasma membranes
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9324
ER  - 

@conference{
author = "Stanojević, Ivana and Milošević, Maja and Petrović, Snježana and Drakulić, Dunja R. and Veličković, Nataša and Horvat, Anica",
year = "2010",
abstract = "Kinetic properties of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases)
in synaptic terminals from whole rat brain were characterised. Three different
NTPDases are present in nervous system and hydrolysing ATP and ADP with
different affinities. ATP and ADP hydrolysis exhibited kinetic properties typical
for all members of the NTPDase, low substrate specificity for tri- and
diphosphonucleosides, divalent cation dependency and insensitivity towards iontransporting
ATPase inhibitors. Kinetic properties of ATPase and ADPase
component of NTPDases depend on postnatal developmental stages of rats, and
indicated different NTPDase family members present in various ontogeny stages.
Lowering in the NTPDases activities could result in a decreased production of
adenosine and change in extracellular ATP/adenosine ratio.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Kinetic properties of ntpdases in rat brain synaptic plasma membranes",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9324"
}

Stanojević, I., Milošević, M., Petrović, S., Drakulić, D. R., Veličković, N.,& Horvat, A.. (2010). Kinetic properties of ntpdases in rat brain synaptic plasma membranes. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9324

Stanojević I, Milošević M, Petrović S, Drakulić DR, Veličković N, Horvat A. Kinetic properties of ntpdases in rat brain synaptic plasma membranes. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9324 .

Stanojević, Ivana, Milošević, Maja, Petrović, Snježana, Drakulić, Dunja R., Veličković, Nataša, Horvat, Anica, "Kinetic properties of ntpdases in rat brain synaptic plasma membranes" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9324 .

TY  - CONF
AU  - Drakulić, Dunja R.
AU  - Stanojević, Ivana
AU  - Milošević, Maja
AU  - Veličković, Nataša
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9382
AB  - The effect of acute gamma irradiation (IR) on enzyme activity of rat brain Ecto-Nucleotide Diphosphohydrolase (E-NTPDase), in presence of adenosine triand diphophashates (ATP and ADP) and divalent cations (Ca2+ and Mg2+), has been investigated. The aim of research was to study the influence of low (50 cGy) and therapeutic (2Gy) doses of whole-body irradiation on rat brain E-NTPDase enzyme activity 24h after treatment in prepubertal and adult rats. Our results suggest that whole-body irradiation could induce modulation of neural activity in rat brain, especially in young rats.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: ii 30-day-old rats
VL  - 1
SP  - 453
EP  - 455
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9382
ER  - 

@conference{
author = "Drakulić, Dunja R. and Stanojević, Ivana and Milošević, Maja and Veličković, Nataša",
year = "2008",
abstract = "The effect of acute gamma irradiation (IR) on enzyme activity of rat brain Ecto-Nucleotide Diphosphohydrolase (E-NTPDase), in presence of adenosine triand diphophashates (ATP and ADP) and divalent cations (Ca2+ and Mg2+), has been investigated. The aim of research was to study the influence of low (50 cGy) and therapeutic (2Gy) doses of whole-body irradiation on rat brain E-NTPDase enzyme activity 24h after treatment in prepubertal and adult rats. Our results suggest that whole-body irradiation could induce modulation of neural activity in rat brain, especially in young rats.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: ii 30-day-old rats",
volume = "1",
pages = "453-455",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9382"
}

Drakulić, D. R., Stanojević, I., Milošević, M.,& Veličković, N.. (2008). Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: ii 30-day-old rats. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 453-455.
https://hdl.handle.net/21.15107/rcub_vinar_9382

Drakulić DR, Stanojević I, Milošević M, Veličković N. Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: ii 30-day-old rats. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:453-455.
https://hdl.handle.net/21.15107/rcub_vinar_9382 .

Drakulić, Dunja R., Stanojević, Ivana, Milošević, Maja, Veličković, Nataša, "Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: ii 30-day-old rats" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):453-455,
https://hdl.handle.net/21.15107/rcub_vinar_9382 .

TY  - CONF
AU  - Stanojević, Ivana
AU  - Drakulić, Dunja R.
AU  - Veličković, Nataša
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9381
AB  - Ionizing radiation affects plasma membrane functions mediated through transmembrane proteins including enzymes. Plasma membrane surface-located enzyme chain of ecto-nucleotide triphospho diphosphohydrolases (NTPDases) are involved in termination of cell purinergic signalization by hydrolysing extracellular adenosine tri- and di-phosphate (ATP and ADP). In the present study, effects of low (50 cGy) and therapeutic (2 Gy) dose of ionizing γ-irradiation on NTPDase activity in early postnatal rat brain neuronal cells were studied. Both low- and therapeutic doses significantly decreased hydrolyze of extracellular ATP (by 11% and 30%) and ADP (18% and 46%) in postnatal rats. These findings indicate that gammaradiation inhibits the enzyme activity in dose-dependent manner. This decreasing NTPDase activity 24h after whole body irradiation may lead to neuronal cell function disturbance, even cell death.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: i 15-day-old rats
VL  - 1
SP  - 450
EP  - 452
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9381
ER  - 

@conference{
author = "Stanojević, Ivana and Drakulić, Dunja R. and Veličković, Nataša",
year = "2008",
abstract = "Ionizing radiation affects plasma membrane functions mediated through transmembrane proteins including enzymes. Plasma membrane surface-located enzyme chain of ecto-nucleotide triphospho diphosphohydrolases (NTPDases) are involved in termination of cell purinergic signalization by hydrolysing extracellular adenosine tri- and di-phosphate (ATP and ADP). In the present study, effects of low (50 cGy) and therapeutic (2 Gy) dose of ionizing γ-irradiation on NTPDase activity in early postnatal rat brain neuronal cells were studied. Both low- and therapeutic doses significantly decreased hydrolyze of extracellular ATP (by 11% and 30%) and ADP (18% and 46%) in postnatal rats. These findings indicate that gammaradiation inhibits the enzyme activity in dose-dependent manner. This decreasing NTPDase activity 24h after whole body irradiation may lead to neuronal cell function disturbance, even cell death.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: i 15-day-old rats",
volume = "1",
pages = "450-452",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9381"
}

Stanojević, I., Drakulić, D. R.,& Veličković, N.. (2008). Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: i 15-day-old rats. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 450-452.
https://hdl.handle.net/21.15107/rcub_vinar_9381

Stanojević I, Drakulić DR, Veličković N. Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: i 15-day-old rats. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:450-452.
https://hdl.handle.net/21.15107/rcub_vinar_9381 .

Stanojević, Ivana, Drakulić, Dunja R., Veličković, Nataša, "Ionizing irradiation affect extracellular nucleotide hydrolysis in brain of rats in different stages of development: i 15-day-old rats" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):450-452,
https://hdl.handle.net/21.15107/rcub_vinar_9381 .

TY  - CONF
AU  - Veličković, Nataša
AU  - Petrović, S.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9374
AB  - Ionizing radiation (IR) is commonly used in the treatment of brain tumors but it can cause significant damage to surrounding normal brain tissue. In this study, heads of young Wistar rats (18 days old) were subjected to a single dose of gamma irradiation (10 Gy) similar to that used in prophylactic brain irradiation of children with acute lymphoblastic leukemia. The kinetics of apoptosis associated proteins (p53 and Bax) were examined by Western blotting and RT-PCR. We observed that p53 mRNA expression was unchanged after irradiation, while induction of p53 protein was rapid, leading to the accumulation of p53 protein in the cytoplasm. In addition, Bax mRNA and protein levels were also increased following cranial irradiation. These results indicate that cranial irradiation, used in terms of prophylactic therapy, is associated with activation of the p53 system, alongside with induction of positive apoptosis regulator Bax.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Radiation-mediated induction of p53 pathway in the rat hippocampus
VL  - 1
SP  - 411
EP  - 413
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9374
ER  - 

@conference{
author = "Veličković, Nataša and Petrović, S.",
year = "2008",
abstract = "Ionizing radiation (IR) is commonly used in the treatment of brain tumors but it can cause significant damage to surrounding normal brain tissue. In this study, heads of young Wistar rats (18 days old) were subjected to a single dose of gamma irradiation (10 Gy) similar to that used in prophylactic brain irradiation of children with acute lymphoblastic leukemia. The kinetics of apoptosis associated proteins (p53 and Bax) were examined by Western blotting and RT-PCR. We observed that p53 mRNA expression was unchanged after irradiation, while induction of p53 protein was rapid, leading to the accumulation of p53 protein in the cytoplasm. In addition, Bax mRNA and protein levels were also increased following cranial irradiation. These results indicate that cranial irradiation, used in terms of prophylactic therapy, is associated with activation of the p53 system, alongside with induction of positive apoptosis regulator Bax.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Radiation-mediated induction of p53 pathway in the rat hippocampus",
volume = "1",
pages = "411-413",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9374"
}

Veličković, N.,& Petrović, S.. (2008). Radiation-mediated induction of p53 pathway in the rat hippocampus. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 411-413.
https://hdl.handle.net/21.15107/rcub_vinar_9374

Veličković N, Petrović S. Radiation-mediated induction of p53 pathway in the rat hippocampus. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:411-413.
https://hdl.handle.net/21.15107/rcub_vinar_9374 .

Veličković, Nataša, Petrović, S., "Radiation-mediated induction of p53 pathway in the rat hippocampus" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):411-413,
https://hdl.handle.net/21.15107/rcub_vinar_9374 .

TY  - CONF
AU  - Veličković, Nataša
AU  - Đorđević, Ana D.
AU  - Popović, Nataša M.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9430
AB  - The tumor-suppressor p53 protein and glucocorticoid receptor (GR) respond to different types of stress. In an attempt to reveal the possibility that p53 protein is involved in the regulation of GR gene expression after low dose cranial irradiation (CI) with 2 Gy, we examined the expression of p53 mRNA and protein as well as expression of GR mRNA and protein in the hippocampus of 18-days-old rats. We found that p53 mRNA expression was unchanged after CI, while induction of p53 protein was rapid, leading to the accumulation of p53 protein in the cytoplasm. Irradiation leads to stimulated GR gene expression in a time-dependent manner, whereas the level of GR protein was unchanged after CI. Co-immunoprecipitation has not showed that wild type p53 protein physically interacts with the GR in the cytoplasm. Our data suggest that the low dose cranial irradiation leads to stabilization of the 53 protein, without interaction with GR protein the cytoplasm.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
T1  - Low dose gamma-irradiation alters the expression of p53 protein in the rat hippocampus
SP  - 413
EP  - 415
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9430
ER  - 

@conference{
author = "Veličković, Nataša and Đorđević, Ana D. and Popović, Nataša M.",
year = "2006",
abstract = "The tumor-suppressor p53 protein and glucocorticoid receptor (GR) respond to different types of stress. In an attempt to reveal the possibility that p53 protein is involved in the regulation of GR gene expression after low dose cranial irradiation (CI) with 2 Gy, we examined the expression of p53 mRNA and protein as well as expression of GR mRNA and protein in the hippocampus of 18-days-old rats. We found that p53 mRNA expression was unchanged after CI, while induction of p53 protein was rapid, leading to the accumulation of p53 protein in the cytoplasm. Irradiation leads to stimulated GR gene expression in a time-dependent manner, whereas the level of GR protein was unchanged after CI. Co-immunoprecipitation has not showed that wild type p53 protein physically interacts with the GR in the cytoplasm. Our data suggest that the low dose cranial irradiation leads to stabilization of the 53 protein, without interaction with GR protein the cytoplasm.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry",
title = "Low dose gamma-irradiation alters the expression of p53 protein in the rat hippocampus",
pages = "413-415",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9430"
}

Veličković, N., Đorđević, A. D.,& Popović, N. M.. (2006). Low dose gamma-irradiation alters the expression of p53 protein in the rat hippocampus. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 413-415.
https://hdl.handle.net/21.15107/rcub_vinar_9430

Veličković N, Đorđević AD, Popović NM. Low dose gamma-irradiation alters the expression of p53 protein in the rat hippocampus. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:413-415.
https://hdl.handle.net/21.15107/rcub_vinar_9430 .

Veličković, Nataša, Đorđević, Ana D., Popović, Nataša M., "Low dose gamma-irradiation alters the expression of p53 protein in the rat hippocampus" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):413-415,
https://hdl.handle.net/21.15107/rcub_vinar_9430 .

TY  - CONF
AU  - Veličković, Nataša
AU  - Đorđević, Ana D.
AU  - Popović, Nataša M.
AU  - Demajo, Miroslav
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9434
AB  - Cranial radiotherapy (CRT) is an effective way to prevent CNS relapse in children with acute lymphoblastic leukemia (ALL). However, CRT also has serious side effects on normal tissues, including long-term neuroendocrine disturbances. In order to test this clinical protocol on animals, we examined the effects of CRT (10 Gy) on the level of mRNA for glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in the hippocampus of 8-days-old rats. Irradiation rapidly stimulated GR gene expression in a time-dependent manner, whereas the time-course of MR mRNA expression showed no statistically significant changes. At postnatal day 42, the level of GR mRNA was diminished while the level of MR mRNA remained unchanged compared to matched controls. Dexamethasone suppression test (DST) revealed the altered nucleocytoplasmic shuttling of activated GR after CRT in 42-days-old rats, as a long-term consequence of gamma irradiation.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
T1  - Different induction of dual corticosteroid receptor system in the rat hippocampus following gamma radiation
SP  - 425
EP  - 427
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9434
ER  - 

@conference{
author = "Veličković, Nataša and Đorđević, Ana D. and Popović, Nataša M. and Demajo, Miroslav",
year = "2006",
abstract = "Cranial radiotherapy (CRT) is an effective way to prevent CNS relapse in children with acute lymphoblastic leukemia (ALL). However, CRT also has serious side effects on normal tissues, including long-term neuroendocrine disturbances. In order to test this clinical protocol on animals, we examined the effects of CRT (10 Gy) on the level of mRNA for glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in the hippocampus of 8-days-old rats. Irradiation rapidly stimulated GR gene expression in a time-dependent manner, whereas the time-course of MR mRNA expression showed no statistically significant changes. At postnatal day 42, the level of GR mRNA was diminished while the level of MR mRNA remained unchanged compared to matched controls. Dexamethasone suppression test (DST) revealed the altered nucleocytoplasmic shuttling of activated GR after CRT in 42-days-old rats, as a long-term consequence of gamma irradiation.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry",
title = "Different induction of dual corticosteroid receptor system in the rat hippocampus following gamma radiation",
pages = "425-427",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9434"
}

Veličković, N., Đorđević, A. D., Popović, N. M.,& Demajo, M.. (2006). Different induction of dual corticosteroid receptor system in the rat hippocampus following gamma radiation. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 425-427.
https://hdl.handle.net/21.15107/rcub_vinar_9434

Veličković N, Đorđević AD, Popović NM, Demajo M. Different induction of dual corticosteroid receptor system in the rat hippocampus following gamma radiation. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:425-427.
https://hdl.handle.net/21.15107/rcub_vinar_9434 .

Veličković, Nataša, Đorđević, Ana D., Popović, Nataša M., Demajo, Miroslav, "Different induction of dual corticosteroid receptor system in the rat hippocampus following gamma radiation" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):425-427,
https://hdl.handle.net/21.15107/rcub_vinar_9434 .