TY  - JOUR
AU  - Budimir, Milica
AU  - Marković, Zoran M.
AU  - Vajdak, Jan
AU  - Jovanović, Svetlana P.
AU  - Kubat, Pavel
AU  - Humpoliček, Petr
AU  - Mičušik, Matej
AU  - Danko, Martin
AU  - Barras, Alexandre
AU  - Milivojević, Dušan
AU  - Špitalsky, Zdenko
AU  - Boukherroub, Rabah
AU  - Todorović-Marković, Biljana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9746
AB  - Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd
T2  - Radiation Physics and Chemistry
T1  - Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment
VL  - 185
SP  - 109499
DO  - 10.1016/j.radphyschem.2021.109499
ER  - 

@article{
author = "Budimir, Milica and Marković, Zoran M. and Vajdak, Jan and Jovanović, Svetlana P. and Kubat, Pavel and Humpoliček, Petr and Mičušik, Matej and Danko, Martin and Barras, Alexandre and Milivojević, Dušan and Špitalsky, Zdenko and Boukherroub, Rabah and Todorović-Marković, Biljana",
year = "2021",
abstract = "Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd",
journal = "Radiation Physics and Chemistry",
title = "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment",
volume = "185",
pages = "109499",
doi = "10.1016/j.radphyschem.2021.109499"
}

Budimir, M., Marković, Z. M., Vajdak, J., Jovanović, S. P., Kubat, P., Humpoliček, P., Mičušik, M., Danko, M., Barras, A., Milivojević, D., Špitalsky, Z., Boukherroub, R.,& Todorović-Marković, B.. (2021). Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry, 185, 109499.
https://doi.org/10.1016/j.radphyschem.2021.109499

Budimir M, Marković ZM, Vajdak J, Jovanović SP, Kubat P, Humpoliček P, Mičušik M, Danko M, Barras A, Milivojević D, Špitalsky Z, Boukherroub R, Todorović-Marković B. Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry. 2021;185:109499.
doi:10.1016/j.radphyschem.2021.109499 .

Budimir, Milica, Marković, Zoran M., Vajdak, Jan, Jovanović, Svetlana P., Kubat, Pavel, Humpoliček, Petr, Mičušik, Matej, Danko, Martin, Barras, Alexandre, Milivojević, Dušan, Špitalsky, Zdenko, Boukherroub, Rabah, Todorović-Marković, Biljana, "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment" in Radiation Physics and Chemistry, 185 (2021):109499,
https://doi.org/10.1016/j.radphyschem.2021.109499 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kovačova, Maria
AU  - Humpoliček, Petr
AU  - Budimir, Milica
AU  - Vajdak, Jan
AU  - Kubat, Pavel
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Danko, Martin
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9615
AB  - Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]
VL  - 32
SP  - 101939
DO  - 10.1016/j.pdpdt.2020.101939
ER  - 

@article{
author = "Marković, Zoran M. and Kovačova, Maria and Humpoliček, Petr and Budimir, Milica and Vajdak, Jan and Kubat, Pavel and Mičušik, Matej and Švajdlenkova, Helena and Danko, Martin and Capakova, Zdenka and Lehocky, Marian and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2020",
abstract = "Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]",
volume = "32",
pages = "101939",
doi = "10.1016/j.pdpdt.2020.101939"
}

Marković, Z. M., Kovačova, M., Humpoliček, P., Budimir, M., Vajdak, J., Kubat, P., Mičušik, M., Švajdlenkova, H., Danko, M., Capakova, Z., Lehocky, M., Todorović-Marković, B.,& Špitalsky, Z.. (2020). Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]. in Photodiagnosis and Photodynamic Therapy, 32, 101939.
https://doi.org/10.1016/j.pdpdt.2020.101939

Marković ZM, Kovačova M, Humpoliček P, Budimir M, Vajdak J, Kubat P, Mičušik M, Švajdlenkova H, Danko M, Capakova Z, Lehocky M, Todorović-Marković B, Špitalsky Z. Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]. in Photodiagnosis and Photodynamic Therapy. 2020;32:101939.
doi:10.1016/j.pdpdt.2020.101939 .

Marković, Zoran M., Kovačova, Maria, Humpoliček, Petr, Budimir, Milica, Vajdak, Jan, Kubat, Pavel, Mičušik, Matej, Švajdlenkova, Helena, Danko, Martin, Capakova, Zdenka, Lehocky, Marian, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Corrigendum “antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae” [photodiagnosis. photodyn. ther. 26 (2019) 342–349]" in Photodiagnosis and Photodynamic Therapy, 32 (2020):101939,
https://doi.org/10.1016/j.pdpdt.2020.101939 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kovačova, Maria
AU  - Humpoliček, Petr
AU  - Budimir, Milica
AU  - Vajdak, Jan
AU  - Kubat, Pavel
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Danko, Martin
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8174
AB  - Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae
VL  - 26
SP  - 342
EP  - 349
DO  - 10.1016/j.pdpdt.2019.04.019
ER  - 

@article{
author = "Marković, Zoran M. and Kovačova, Maria and Humpoliček, Petr and Budimir, Milica and Vajdak, Jan and Kubat, Pavel and Mičušik, Matej and Švajdlenkova, Helena and Danko, Martin and Capakova, Zdenka and Lehocky, Marian and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2019",
abstract = "Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae",
volume = "26",
pages = "342-349",
doi = "10.1016/j.pdpdt.2019.04.019"
}

Marković, Z. M., Kovačova, M., Humpoliček, P., Budimir, M., Vajdak, J., Kubat, P., Mičušik, M., Švajdlenkova, H., Danko, M., Capakova, Z., Lehocky, M., Todorović-Marković, B.,& Špitalsky, Z.. (2019). Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy, 26, 342-349.
https://doi.org/10.1016/j.pdpdt.2019.04.019

Marković ZM, Kovačova M, Humpoliček P, Budimir M, Vajdak J, Kubat P, Mičušik M, Švajdlenkova H, Danko M, Capakova Z, Lehocky M, Todorović-Marković B, Špitalsky Z. Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy. 2019;26:342-349.
doi:10.1016/j.pdpdt.2019.04.019 .

Marković, Zoran M., Kovačova, Maria, Humpoliček, Petr, Budimir, Milica, Vajdak, Jan, Kubat, Pavel, Mičušik, Matej, Švajdlenkova, Helena, Danko, Martin, Capakova, Zdenka, Lehocky, Marian, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae" in Photodiagnosis and Photodynamic Therapy, 26 (2019):342-349,
https://doi.org/10.1016/j.pdpdt.2019.04.019 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kovačova, Maria
AU  - Humpoliček, Petr
AU  - Budimir, Milica
AU  - Vajdak, Jan
AU  - Kubat, Pavel
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Danko, Martin
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8187
AB  - Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae
VL  - 26
SP  - 342
EP  - 349
DO  - 10.1016/j.pdpdt.2019.04.019
ER  - 

@article{
author = "Marković, Zoran M. and Kovačova, Maria and Humpoliček, Petr and Budimir, Milica and Vajdak, Jan and Kubat, Pavel and Mičušik, Matej and Švajdlenkova, Helena and Danko, Martin and Capakova, Zdenka and Lehocky, Marian and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2019",
abstract = "Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation. © 2019 Elsevier B.V.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae",
volume = "26",
pages = "342-349",
doi = "10.1016/j.pdpdt.2019.04.019"
}

Marković, Z. M., Kovačova, M., Humpoliček, P., Budimir, M., Vajdak, J., Kubat, P., Mičušik, M., Švajdlenkova, H., Danko, M., Capakova, Z., Lehocky, M., Todorović-Marković, B.,& Špitalsky, Z.. (2019). Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy, 26, 342-349.
https://doi.org/10.1016/j.pdpdt.2019.04.019

Marković ZM, Kovačova M, Humpoliček P, Budimir M, Vajdak J, Kubat P, Mičušik M, Švajdlenkova H, Danko M, Capakova Z, Lehocky M, Todorović-Marković B, Špitalsky Z. Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. in Photodiagnosis and Photodynamic Therapy. 2019;26:342-349.
doi:10.1016/j.pdpdt.2019.04.019 .

Marković, Zoran M., Kovačova, Maria, Humpoliček, Petr, Budimir, Milica, Vajdak, Jan, Kubat, Pavel, Mičušik, Matej, Švajdlenkova, Helena, Danko, Martin, Capakova, Zdenka, Lehocky, Marian, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae" in Photodiagnosis and Photodynamic Therapy, 26 (2019):342-349,
https://doi.org/10.1016/j.pdpdt.2019.04.019 . .

TY  - JOUR
AU  - Kovačova, Maria
AU  - Marković, Zoran M.
AU  - Humpoliček, Petr
AU  - Mičušik, Matej
AU  - Švajdlenkova, Helena
AU  - Kleinova, Angela
AU  - Danko, Martin
AU  - Kubat, Pavel
AU  - Vajdak, Jan
AU  - Capakova, Zdenka
AU  - Lehocky, Marian
AU  - Munster, Lukaš
AU  - Todorović-Marković, Biljana
AU  - Špitalsky, Zdenko
PY  - 2018
UR  - http://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00582
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8064
AB  - Development of new types of antibacterial coatings or nanocomposites is of great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well as structural, photocatalytic, and antibacterial properties of photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production of these nanocomposites. Hydrophobic carbon quantum dots/polyurethane nanocomposites were found to be highly effective generator of singlet oxygen upon irradiation by low-power blue light. Analysis of conducted antibacterial tests on Staphyloccocus aureus and Escherichia coli showed 5-log bactericidal effect of these nanocomposites within 60 min of irradiation. Very powerful degradation of dye (rose bengal) was observed within 180 min of blue light irradiation of the nanocomposites. Biocompatibility studies revealed that nanocomposites were not cytotoxic against mouse embryonic fibroblast cell line, whereas they showed moderate cytotoxicity toward adenocarcinomic human epithelial cell line. Minor hemolytic effect of these nanocomposites toward red blood cells was revealed.
T2  - ACS Biomaterials Science and Engineering
T1  - Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents
VL  - 4
IS  - 12
SP  - 3983
EP  - 3993
DO  - 10.1021/acsbiomaterials.8b00582
ER  - 

@article{
author = "Kovačova, Maria and Marković, Zoran M. and Humpoliček, Petr and Mičušik, Matej and Švajdlenkova, Helena and Kleinova, Angela and Danko, Martin and Kubat, Pavel and Vajdak, Jan and Capakova, Zdenka and Lehocky, Marian and Munster, Lukaš and Todorović-Marković, Biljana and Špitalsky, Zdenko",
year = "2018",
abstract = "Development of new types of antibacterial coatings or nanocomposites is of great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well as structural, photocatalytic, and antibacterial properties of photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production of these nanocomposites. Hydrophobic carbon quantum dots/polyurethane nanocomposites were found to be highly effective generator of singlet oxygen upon irradiation by low-power blue light. Analysis of conducted antibacterial tests on Staphyloccocus aureus and Escherichia coli showed 5-log bactericidal effect of these nanocomposites within 60 min of irradiation. Very powerful degradation of dye (rose bengal) was observed within 180 min of blue light irradiation of the nanocomposites. Biocompatibility studies revealed that nanocomposites were not cytotoxic against mouse embryonic fibroblast cell line, whereas they showed moderate cytotoxicity toward adenocarcinomic human epithelial cell line. Minor hemolytic effect of these nanocomposites toward red blood cells was revealed.",
journal = "ACS Biomaterials Science and Engineering",
title = "Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents",
volume = "4",
number = "12",
pages = "3983-3993",
doi = "10.1021/acsbiomaterials.8b00582"
}

Kovačova, M., Marković, Z. M., Humpoliček, P., Mičušik, M., Švajdlenkova, H., Kleinova, A., Danko, M., Kubat, P., Vajdak, J., Capakova, Z., Lehocky, M., Munster, L., Todorović-Marković, B.,& Špitalsky, Z.. (2018). Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents. in ACS Biomaterials Science and Engineering, 4(12), 3983-3993.
https://doi.org/10.1021/acsbiomaterials.8b00582

Kovačova M, Marković ZM, Humpoliček P, Mičušik M, Švajdlenkova H, Kleinova A, Danko M, Kubat P, Vajdak J, Capakova Z, Lehocky M, Munster L, Todorović-Marković B, Špitalsky Z. Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents. in ACS Biomaterials Science and Engineering. 2018;4(12):3983-3993.
doi:10.1021/acsbiomaterials.8b00582 .

Kovačova, Maria, Marković, Zoran M., Humpoliček, Petr, Mičušik, Matej, Švajdlenkova, Helena, Kleinova, Angela, Danko, Martin, Kubat, Pavel, Vajdak, Jan, Capakova, Zdenka, Lehocky, Marian, Munster, Lukaš, Todorović-Marković, Biljana, Špitalsky, Zdenko, "Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents" in ACS Biomaterials Science and Engineering, 4, no. 12 (2018):3983-3993,
https://doi.org/10.1021/acsbiomaterials.8b00582 . .