TY  - JOUR
AU  - Theodosiou, Maria
AU  - Sakellis, Elias
AU  - Boukos, Nikos
AU  - Kusigerski, Vladan
AU  - Kalska-Szostko, Beata
AU  - Efthimiadou, Eleni
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10346
AB  - Magnetic hyperthermia (MHT) is in the spotlight of nanomedical research for the treatment of cancer employing magnetic iron oxide nanoparticles and their intrinsic capability for heat dissipation under an alternating magnetic field (AMF). Herein we focus on the synthesis of iron oxide nanoflowers (Nfs) of different sizes (15 and 35 nm) and coatings (bare, citrate, and Rhodamine B) while comparing their physicochemical and magnetothermal properties. We encapsulated colloidally stable citrate coated Nfs, of both sizes, in thermosensitive liposomes via extrusion, and RhB was loaded in the lipid bilayer. All formulations proved hemocompatible and cytocompatible. We found that 35 nm Nfs, at lower concentrations than 15 nm Nfs, served better as nanoheaters for magnetic hyperthermia applications. In vitro, magnetic hyperthermia results showed promising therapeutic and imaging potential for RhB loaded magnetoliposomes containing 35 nm Nfs against LLC and CULA cell lines of lung adenocarcinoma.
T2  - Scientific Reports
T1  - Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma
VL  - 12
IS  - 1
SP  - 8697
DO  - 10.1038/s41598-022-12687-3
ER  - 

@article{
author = "Theodosiou, Maria and Sakellis, Elias and Boukos, Nikos and Kusigerski, Vladan and Kalska-Szostko, Beata and Efthimiadou, Eleni",
year = "2022",
abstract = "Magnetic hyperthermia (MHT) is in the spotlight of nanomedical research for the treatment of cancer employing magnetic iron oxide nanoparticles and their intrinsic capability for heat dissipation under an alternating magnetic field (AMF). Herein we focus on the synthesis of iron oxide nanoflowers (Nfs) of different sizes (15 and 35 nm) and coatings (bare, citrate, and Rhodamine B) while comparing their physicochemical and magnetothermal properties. We encapsulated colloidally stable citrate coated Nfs, of both sizes, in thermosensitive liposomes via extrusion, and RhB was loaded in the lipid bilayer. All formulations proved hemocompatible and cytocompatible. We found that 35 nm Nfs, at lower concentrations than 15 nm Nfs, served better as nanoheaters for magnetic hyperthermia applications. In vitro, magnetic hyperthermia results showed promising therapeutic and imaging potential for RhB loaded magnetoliposomes containing 35 nm Nfs against LLC and CULA cell lines of lung adenocarcinoma.",
journal = "Scientific Reports",
title = "Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma",
volume = "12",
number = "1",
pages = "8697",
doi = "10.1038/s41598-022-12687-3"
}

Theodosiou, M., Sakellis, E., Boukos, N., Kusigerski, V., Kalska-Szostko, B.,& Efthimiadou, E.. (2022). Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma. in Scientific Reports, 12(1), 8697.
https://doi.org/10.1038/s41598-022-12687-3

Theodosiou M, Sakellis E, Boukos N, Kusigerski V, Kalska-Szostko B, Efthimiadou E. Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma. in Scientific Reports. 2022;12(1):8697.
doi:10.1038/s41598-022-12687-3 .

Theodosiou, Maria, Sakellis, Elias, Boukos, Nikos, Kusigerski, Vladan, Kalska-Szostko, Beata, Efthimiadou, Eleni, "Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma" in Scientific Reports, 12, no. 1 (2022):8697,
https://doi.org/10.1038/s41598-022-12687-3 . .

TY  - JOUR
AU  - Spirou, Spiridon
AU  - Costa Lima, Sofia
AU  - Bouziotis, Penelope
AU  - Vranješ-Đurić, Sanja
AU  - Efthimiadou, Eleni
AU  - Laurenzana, Anna
AU  - Barbosa, Ana
AU  - Garcia-Alonso, Ignacio
AU  - Jones, Carlton
AU  - Janković, Drina
AU  - Gobbo, Oliviero
PY  - 2018
UR  - http://www.mdpi.com/2079-4991/8/5/306
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7707
AB  - Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.
T2  - Nanomaterials
T1  - Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy
VL  - 8
IS  - 5
SP  - 306
DO  - 10.3390/nano8050306
ER  - 

@article{
author = "Spirou, Spiridon and Costa Lima, Sofia and Bouziotis, Penelope and Vranješ-Đurić, Sanja and Efthimiadou, Eleni and Laurenzana, Anna and Barbosa, Ana and Garcia-Alonso, Ignacio and Jones, Carlton and Janković, Drina and Gobbo, Oliviero",
year = "2018",
abstract = "Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.",
journal = "Nanomaterials",
title = "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy",
volume = "8",
number = "5",
pages = "306",
doi = "10.3390/nano8050306"
}

Spirou, S., Costa Lima, S., Bouziotis, P., Vranješ-Đurić, S., Efthimiadou, E., Laurenzana, A., Barbosa, A., Garcia-Alonso, I., Jones, C., Janković, D.,& Gobbo, O.. (2018). Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy. in Nanomaterials, 8(5), 306.
https://doi.org/10.3390/nano8050306

Spirou S, Costa Lima S, Bouziotis P, Vranješ-Đurić S, Efthimiadou E, Laurenzana A, Barbosa A, Garcia-Alonso I, Jones C, Janković D, Gobbo O. Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy. in Nanomaterials. 2018;8(5):306.
doi:10.3390/nano8050306 .

Spirou, Spiridon, Costa Lima, Sofia, Bouziotis, Penelope, Vranješ-Đurić, Sanja, Efthimiadou, Eleni, Laurenzana, Anna, Barbosa, Ana, Garcia-Alonso, Ignacio, Jones, Carlton, Janković, Drina, Gobbo, Oliviero, "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy" in Nanomaterials, 8, no. 5 (2018):306,
https://doi.org/10.3390/nano8050306 . .