TY  - JOUR
AU  - Inta, Dragos
AU  - Vogt, M. A.
AU  - Luoni, A.
AU  - Filipović, Dragana
AU  - Lima-Ojeda, J. M.
AU  - Pfeiffer, N.
AU  - Gasparini, F.
AU  - Riva, M. A.
AU  - Gass, Peter
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5328
AB  - Glutamatergic mechanisms regulate neuronal circuits implicated in mood and anxiety. Emotional disorders as anxiety and depression are particularly difficult to treat during aging and mechanisms underlying emotional disturbances in the brain of the elderly are poorly understood. This may result from the small number of studies investigating these disorders in aged animals. Among glutamate receptors, metabotropic mGlu5 receptors are thought to play an important role, since their pharmacological blockade induces strong anxiolytic effects. However, the implication of mGlu5 in regulating anxiety is not yet completely understood. Here we analyzed both young adult and aged mice lacking mGlu5 receptors, to clarify, if genetic deletion of the receptor induces similar to pharmacological blockade anxiolytic effects. Unexpectedly, mGlu5 receptor knockout (KO) mice showed increased anxiety accentuating with aging. In contrast, young adult mice displayed an anti-depressive-like phenotype that was no longer detectable in aged animals. Our data support important distinct roles of mGlu5 receptors in modulating anxiety and depression during aging. (C) 2012 Elsevier B.V. All rights reserved.
T2  - Behavioural Brain Research
T1  - Significant increase in anxiety during aging in mGlu5 receptor knockout mice
VL  - 241
SP  - 27
EP  - 31
DO  - 10.1016/j.bbr.2012.11.042
ER  - 

@article{
author = "Inta, Dragos and Vogt, M. A. and Luoni, A. and Filipović, Dragana and Lima-Ojeda, J. M. and Pfeiffer, N. and Gasparini, F. and Riva, M. A. and Gass, Peter",
year = "2013",
abstract = "Glutamatergic mechanisms regulate neuronal circuits implicated in mood and anxiety. Emotional disorders as anxiety and depression are particularly difficult to treat during aging and mechanisms underlying emotional disturbances in the brain of the elderly are poorly understood. This may result from the small number of studies investigating these disorders in aged animals. Among glutamate receptors, metabotropic mGlu5 receptors are thought to play an important role, since their pharmacological blockade induces strong anxiolytic effects. However, the implication of mGlu5 in regulating anxiety is not yet completely understood. Here we analyzed both young adult and aged mice lacking mGlu5 receptors, to clarify, if genetic deletion of the receptor induces similar to pharmacological blockade anxiolytic effects. Unexpectedly, mGlu5 receptor knockout (KO) mice showed increased anxiety accentuating with aging. In contrast, young adult mice displayed an anti-depressive-like phenotype that was no longer detectable in aged animals. Our data support important distinct roles of mGlu5 receptors in modulating anxiety and depression during aging. (C) 2012 Elsevier B.V. All rights reserved.",
journal = "Behavioural Brain Research",
title = "Significant increase in anxiety during aging in mGlu5 receptor knockout mice",
volume = "241",
pages = "27-31",
doi = "10.1016/j.bbr.2012.11.042"
}

Inta, D., Vogt, M. A., Luoni, A., Filipović, D., Lima-Ojeda, J. M., Pfeiffer, N., Gasparini, F., Riva, M. A.,& Gass, P.. (2013). Significant increase in anxiety during aging in mGlu5 receptor knockout mice. in Behavioural Brain Research, 241, 27-31.
https://doi.org/10.1016/j.bbr.2012.11.042

Inta D, Vogt MA, Luoni A, Filipović D, Lima-Ojeda JM, Pfeiffer N, Gasparini F, Riva MA, Gass P. Significant increase in anxiety during aging in mGlu5 receptor knockout mice. in Behavioural Brain Research. 2013;241:27-31.
doi:10.1016/j.bbr.2012.11.042 .

Inta, Dragos, Vogt, M. A., Luoni, A., Filipović, Dragana, Lima-Ojeda, J. M., Pfeiffer, N., Gasparini, F., Riva, M. A., Gass, Peter, "Significant increase in anxiety during aging in mGlu5 receptor knockout mice" in Behavioural Brain Research, 241 (2013):27-31,
https://doi.org/10.1016/j.bbr.2012.11.042 . .