TY  - JOUR
AU  - Stevanović, Momir
AU  - Selaković, Dragica
AU  - Vasović, Miroslav
AU  - Ljujić, Biljana
AU  - Živanović, Suzana
AU  - Papić, Miloš
AU  - Živanović, Marko
AU  - Milivojević, Nevena
AU  - Mijović, Milica
AU  - Tabaković, Saša Z.
AU  - Jokanović, Vukoman R.
AU  - Arnaut, Aleksandra
AU  - Milanović, Pavle
AU  - Jovičić, Nemanja
AU  - Rosić, Gvozden
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10214
AB  - Reconstruction of jaw bone defects present a significant problem because of specific aesthetic and functional requirements. Although widely used, the transplantation of standard autograft and allograft materials is still associated with significant constraints. Composite scaffolds, combining advantages of biodegradable polymers with bioceramics, have potential to overcome limitations of standard grafts. Polyethyleneimine could be an interesting novel biocompatible polymer for scaffold construction due to its biocompatibility and chemical structure. To date, there have been no in vivo studies assessing biological properties of hydroxyapatite bioceramics scaffold modified with polyethyleneimine. The aim of this study was to evaluate in vivo effects of composite scaffolds of hydroxyapatite ceramics and poly(lactide-co-glycolide) and novel polyethyleneimine on bone repair in swine’s mandibular defects, and to compare them to conventional bone allograft (BioOss). Scaffolds were prepared using the method of polymer foam template in three steps. Pigs, 3 months old, were used and defects were made in the canine, premolar, and molar area of their mandibles. Four months following the surgical procedure, the bone was analyzed using radiological, histological, and gene expression techniques. Hydroxyapatite ceramics/polyethyleneimine composite scaffold demonstrated improved biological behavior compared to conventional allograft in treatment of swine’s mandibular defects, in terms of bone density and bone tissue histological characteristics.
T2  - Molecules
T1  - Comparison of Hydroxyapatite/Poly(lactide-co-glycolide) and Hydroxyapatite/Polyethyleneimine Composite Scaffolds in Bone Regeneration of Swine Mandibular Critical Size Defects: In Vivo Study
VL  - 27
IS  - 5
SP  - 1694
DO  - 10.3390/molecules27051694
ER  - 

@article{
author = "Stevanović, Momir and Selaković, Dragica and Vasović, Miroslav and Ljujić, Biljana and Živanović, Suzana and Papić, Miloš and Živanović, Marko and Milivojević, Nevena and Mijović, Milica and Tabaković, Saša Z. and Jokanović, Vukoman R. and Arnaut, Aleksandra and Milanović, Pavle and Jovičić, Nemanja and Rosić, Gvozden",
year = "2022",
abstract = "Reconstruction of jaw bone defects present a significant problem because of specific aesthetic and functional requirements. Although widely used, the transplantation of standard autograft and allograft materials is still associated with significant constraints. Composite scaffolds, combining advantages of biodegradable polymers with bioceramics, have potential to overcome limitations of standard grafts. Polyethyleneimine could be an interesting novel biocompatible polymer for scaffold construction due to its biocompatibility and chemical structure. To date, there have been no in vivo studies assessing biological properties of hydroxyapatite bioceramics scaffold modified with polyethyleneimine. The aim of this study was to evaluate in vivo effects of composite scaffolds of hydroxyapatite ceramics and poly(lactide-co-glycolide) and novel polyethyleneimine on bone repair in swine’s mandibular defects, and to compare them to conventional bone allograft (BioOss). Scaffolds were prepared using the method of polymer foam template in three steps. Pigs, 3 months old, were used and defects were made in the canine, premolar, and molar area of their mandibles. Four months following the surgical procedure, the bone was analyzed using radiological, histological, and gene expression techniques. Hydroxyapatite ceramics/polyethyleneimine composite scaffold demonstrated improved biological behavior compared to conventional allograft in treatment of swine’s mandibular defects, in terms of bone density and bone tissue histological characteristics.",
journal = "Molecules",
title = "Comparison of Hydroxyapatite/Poly(lactide-co-glycolide) and Hydroxyapatite/Polyethyleneimine Composite Scaffolds in Bone Regeneration of Swine Mandibular Critical Size Defects: In Vivo Study",
volume = "27",
number = "5",
pages = "1694",
doi = "10.3390/molecules27051694"
}

Stevanović, M., Selaković, D., Vasović, M., Ljujić, B., Živanović, S., Papić, M., Živanović, M., Milivojević, N., Mijović, M., Tabaković, S. Z., Jokanović, V. R., Arnaut, A., Milanović, P., Jovičić, N.,& Rosić, G.. (2022). Comparison of Hydroxyapatite/Poly(lactide-co-glycolide) and Hydroxyapatite/Polyethyleneimine Composite Scaffolds in Bone Regeneration of Swine Mandibular Critical Size Defects: In Vivo Study. in Molecules, 27(5), 1694.
https://doi.org/10.3390/molecules27051694

Stevanović M, Selaković D, Vasović M, Ljujić B, Živanović S, Papić M, Živanović M, Milivojević N, Mijović M, Tabaković SZ, Jokanović VR, Arnaut A, Milanović P, Jovičić N, Rosić G. Comparison of Hydroxyapatite/Poly(lactide-co-glycolide) and Hydroxyapatite/Polyethyleneimine Composite Scaffolds in Bone Regeneration of Swine Mandibular Critical Size Defects: In Vivo Study. in Molecules. 2022;27(5):1694.
doi:10.3390/molecules27051694 .

Stevanović, Momir, Selaković, Dragica, Vasović, Miroslav, Ljujić, Biljana, Živanović, Suzana, Papić, Miloš, Živanović, Marko, Milivojević, Nevena, Mijović, Milica, Tabaković, Saša Z., Jokanović, Vukoman R., Arnaut, Aleksandra, Milanović, Pavle, Jovičić, Nemanja, Rosić, Gvozden, "Comparison of Hydroxyapatite/Poly(lactide-co-glycolide) and Hydroxyapatite/Polyethyleneimine Composite Scaffolds in Bone Regeneration of Swine Mandibular Critical Size Defects: In Vivo Study" in Molecules, 27, no. 5 (2022):1694,
https://doi.org/10.3390/molecules27051694 . .