TY  - JOUR
AU  - Nešić, Aleksandra
AU  - Meseldžija, Slađana
AU  - Davidović, Slađana
AU  - Miljković, Miona
AU  - Onjia, Antonije
AU  - Dimitrijević, Suzana
AU  - Santagata, Gabriella
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11450
AB  - In this study, pectin-based films blended with alginate and crosslinked with copper ions for potential application in agriculture were investigated. Copper was selected as crosslinking agent, due to its key role as a plant micronutrient, antifungal ability, and focal activity in the pectin crosslinking process. FTIR analysis confirmed the interactions between pectin, alginate and copper salt. The inclusion of alginate in film improved the binding activity of copper ions, providing denser 3d network with enhanced physical-chemical properties. The crosslinked film containing 60 wt% of pectin and 40 wt% of alginate had the highest tensile strength (59.8 MPa), highest UV barrier (transmission of light=0%), and the lowest swelling degree (121%) and water vapor permeability (0.320 ng/ m s Pa). Moreover, the release of copper ions from this formulation after 28 days of immersion in water and soil was 9 and 13 ppm, respectively. The biodegradation rate after 28 days of exposure in the soil was 54%. Nevertheless, all crosslinked pectin-alginate films inhibited the growth of the Fusarium and Aspergillus phytopathogens and demonstrated non-phytotoxicity on germination and growth of wheat. Hence, the system developed in this work can potentially be used as novel, bio-active, tunable plant protective biodegradable foliar spray in agriculture sector.
T2  - Industrial Crops and Products
T1  - Characterization of antifungal citrus pectin-based films for potential agricultural application
VL  - 204
SP  - 117386
DO  - 10.1016/j.indcrop.2023.117386
ER  - 

@article{
author = "Nešić, Aleksandra and Meseldžija, Slađana and Davidović, Slađana and Miljković, Miona and Onjia, Antonije and Dimitrijević, Suzana and Santagata, Gabriella",
year = "2023",
abstract = "In this study, pectin-based films blended with alginate and crosslinked with copper ions for potential application in agriculture were investigated. Copper was selected as crosslinking agent, due to its key role as a plant micronutrient, antifungal ability, and focal activity in the pectin crosslinking process. FTIR analysis confirmed the interactions between pectin, alginate and copper salt. The inclusion of alginate in film improved the binding activity of copper ions, providing denser 3d network with enhanced physical-chemical properties. The crosslinked film containing 60 wt% of pectin and 40 wt% of alginate had the highest tensile strength (59.8 MPa), highest UV barrier (transmission of light=0%), and the lowest swelling degree (121%) and water vapor permeability (0.320 ng/ m s Pa). Moreover, the release of copper ions from this formulation after 28 days of immersion in water and soil was 9 and 13 ppm, respectively. The biodegradation rate after 28 days of exposure in the soil was 54%. Nevertheless, all crosslinked pectin-alginate films inhibited the growth of the Fusarium and Aspergillus phytopathogens and demonstrated non-phytotoxicity on germination and growth of wheat. Hence, the system developed in this work can potentially be used as novel, bio-active, tunable plant protective biodegradable foliar spray in agriculture sector.",
journal = "Industrial Crops and Products",
title = "Characterization of antifungal citrus pectin-based films for potential agricultural application",
volume = "204",
pages = "117386",
doi = "10.1016/j.indcrop.2023.117386"
}

Nešić, A., Meseldžija, S., Davidović, S., Miljković, M., Onjia, A., Dimitrijević, S.,& Santagata, G.. (2023). Characterization of antifungal citrus pectin-based films for potential agricultural application. in Industrial Crops and Products, 204, 117386.
https://doi.org/10.1016/j.indcrop.2023.117386

Nešić A, Meseldžija S, Davidović S, Miljković M, Onjia A, Dimitrijević S, Santagata G. Characterization of antifungal citrus pectin-based films for potential agricultural application. in Industrial Crops and Products. 2023;204:117386.
doi:10.1016/j.indcrop.2023.117386 .

Nešić, Aleksandra, Meseldžija, Slađana, Davidović, Slađana, Miljković, Miona, Onjia, Antonije, Dimitrijević, Suzana, Santagata, Gabriella, "Characterization of antifungal citrus pectin-based films for potential agricultural application" in Industrial Crops and Products, 204 (2023):117386,
https://doi.org/10.1016/j.indcrop.2023.117386 . .

TY  - JOUR
AU  - Nešić, Aleksandra
AU  - De Bonis, Maria Valeria
AU  - Dal Poggetto, Giovanni
AU  - Ruocco, Gianpaolo
AU  - Santagata, Gabriella
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11390
AB  - This paper highlights the potential of Sargassum algae, recovered from raw beach seaweed wastes, as a valid source of valuable sodium alginate. Alginate is a biodegradable, highly attractive polysaccharide widely used in food, pharmaceuticals, and biomedicine applications. The aim of this work is to employ a new eco-sustainable and cost-effective extractive method to obtain alginate as a raw material from pollutant organic Sargassum seaweeds. Algae were exposed to microwave pre-treatment under static and dynamic conditions, and three different extractive protocols were followed: (a) conventional, (b) hot water and (c) alkaline method. All samples were characterized by GPC, SEM, FTIR/ATR and TGA. It was found that alginate’s best performances were obtained by the microwave dynamic pre-treatment method followed by alkaline extractive protocol. Nevertheless, the microwave pre-treatment of algae allowed the easiest breaking of their cell walls and the following fast releasing of sodium alginate. The authors demonstrated that microwave-enhanced extraction is an effective way to obtain sodium alginate from Sargassum-stranded seaweed waste materials in a cost-effective and eco-sustainable approach. They also assessed their applications as mulching films for agricultural applications.
T2  - Polymers
T1  - Microwave Assisted Extraction of Raw Alginate as a Sustainable and Cost-Effective Method to Treat Beach-Accumulated Sargassum Algae
VL  - 15
IS  - 14
SP  - 2979
DO  - 10.3390/polym15142979
ER  - 

@article{
author = "Nešić, Aleksandra and De Bonis, Maria Valeria and Dal Poggetto, Giovanni and Ruocco, Gianpaolo and Santagata, Gabriella",
year = "2023",
abstract = "This paper highlights the potential of Sargassum algae, recovered from raw beach seaweed wastes, as a valid source of valuable sodium alginate. Alginate is a biodegradable, highly attractive polysaccharide widely used in food, pharmaceuticals, and biomedicine applications. The aim of this work is to employ a new eco-sustainable and cost-effective extractive method to obtain alginate as a raw material from pollutant organic Sargassum seaweeds. Algae were exposed to microwave pre-treatment under static and dynamic conditions, and three different extractive protocols were followed: (a) conventional, (b) hot water and (c) alkaline method. All samples were characterized by GPC, SEM, FTIR/ATR and TGA. It was found that alginate’s best performances were obtained by the microwave dynamic pre-treatment method followed by alkaline extractive protocol. Nevertheless, the microwave pre-treatment of algae allowed the easiest breaking of their cell walls and the following fast releasing of sodium alginate. The authors demonstrated that microwave-enhanced extraction is an effective way to obtain sodium alginate from Sargassum-stranded seaweed waste materials in a cost-effective and eco-sustainable approach. They also assessed their applications as mulching films for agricultural applications.",
journal = "Polymers",
title = "Microwave Assisted Extraction of Raw Alginate as a Sustainable and Cost-Effective Method to Treat Beach-Accumulated Sargassum Algae",
volume = "15",
number = "14",
pages = "2979",
doi = "10.3390/polym15142979"
}

Nešić, A., De Bonis, M. V., Dal Poggetto, G., Ruocco, G.,& Santagata, G.. (2023). Microwave Assisted Extraction of Raw Alginate as a Sustainable and Cost-Effective Method to Treat Beach-Accumulated Sargassum Algae. in Polymers, 15(14), 2979.
https://doi.org/10.3390/polym15142979

Nešić A, De Bonis MV, Dal Poggetto G, Ruocco G, Santagata G. Microwave Assisted Extraction of Raw Alginate as a Sustainable and Cost-Effective Method to Treat Beach-Accumulated Sargassum Algae. in Polymers. 2023;15(14):2979.
doi:10.3390/polym15142979 .

Nešić, Aleksandra, De Bonis, Maria Valeria, Dal Poggetto, Giovanni, Ruocco, Gianpaolo, Santagata, Gabriella, "Microwave Assisted Extraction of Raw Alginate as a Sustainable and Cost-Effective Method to Treat Beach-Accumulated Sargassum Algae" in Polymers, 15, no. 14 (2023):2979,
https://doi.org/10.3390/polym15142979 . .

TY  - CHAP
AU  - Nešić, Aleksandra
AU  - Moeini, Arash
AU  - Santagata, Gabriella
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10717
AB  - Marine environment has been recognized as a valuable source of bioactive polymers with industrial potential. Some families of polysaccharides, such as chitosan and alginate, are highly abundant renewable biomasses that might be obtained from microorganisms, shrimps, clams, or algae. These polysaccharides exhibit various biological activities, including antioxidant, anti-infection, anticoagulant, anti-inflammatory, and antidiabetic effects. Besides their natural biological and structural functions, the marine biopolymers can be tailored to be new biomaterials with novel functionalities. Hence, this chapter will summarize the most important novel concepts and inventions along with marine biopolymer engineering.
T2  - Sustainability of Polymeric Materials
T1  - Marine biopolymers: alginate and chitosan
SP  - 73
EP  - 92
DO  - 10.1515/9783110590586-004
ER  - 

@inbook{
author = "Nešić, Aleksandra and Moeini, Arash and Santagata, Gabriella",
year = "2020",
abstract = "Marine environment has been recognized as a valuable source of bioactive polymers with industrial potential. Some families of polysaccharides, such as chitosan and alginate, are highly abundant renewable biomasses that might be obtained from microorganisms, shrimps, clams, or algae. These polysaccharides exhibit various biological activities, including antioxidant, anti-infection, anticoagulant, anti-inflammatory, and antidiabetic effects. Besides their natural biological and structural functions, the marine biopolymers can be tailored to be new biomaterials with novel functionalities. Hence, this chapter will summarize the most important novel concepts and inventions along with marine biopolymer engineering.",
journal = "Sustainability of Polymeric Materials",
booktitle = "Marine biopolymers: alginate and chitosan",
pages = "73-92",
doi = "10.1515/9783110590586-004"
}

Nešić, A., Moeini, A.,& Santagata, G.. (2020). Marine biopolymers: alginate and chitosan. in Sustainability of Polymeric Materials, 73-92.
https://doi.org/10.1515/9783110590586-004

Nešić A, Moeini A, Santagata G. Marine biopolymers: alginate and chitosan. in Sustainability of Polymeric Materials. 2020;:73-92.
doi:10.1515/9783110590586-004 .

Nešić, Aleksandra, Moeini, Arash, Santagata, Gabriella, "Marine biopolymers: alginate and chitosan" in Sustainability of Polymeric Materials (2020):73-92,
https://doi.org/10.1515/9783110590586-004 . .

TY  - JOUR
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7578
AB  - The aim of this study was the development of novel polysaccharide based films intended to be used as edible food packaging material. The films were prepared by solution casting method using highly methoxylated pectin (PEC) and poly(ethylene glycol) (PEG) of various molecular weights (400, 600 and 1000 gmol(-1)) in different ratios (5:1, 3:1 and 1:1). The film formation was supported by hydrogen bonding between PEC and PEG, which was evidenced by means of ATR-FTIR and NMR analysis. TGA revealed that generally PEG behaves like a pro-degrading agent for pectin, except in the case of PEC/PEG film with a ratio of 1:1. Furthermore, DSC thermograms indicated that PEG1000 exists as a separate phase in the pectin matrix while the formulations with PEG400 and PEG600 showed mainly amorphous morphology. The addition of PEG enhanced the plasticization of PEC films, as evidenced by progressive decreasing of the glass transition temperature values (T-g). The tensile test measurements showed that increasing concentration of PEG produced weaker and more flexibile films. Due to the increased molecular mobility, the pectin phase became more permeable to water vapor as the PEG concentration increased. The obtained results showed that the combination of both polymers resulted in interesting bio -inspired edible films with the potential to compete with commercially used synthetic package materials. (C) 2017 Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Food Hydrocolloids
T1  - Edible blend films of pectin and poly(ethylene glycol): Preparation and physico-chemical evaluation
VL  - 77
SP  - 494
EP  - 501
DO  - 10.1016/j.foodhyd.2017.10.027
ER  - 

@article{
year = "2018",
abstract = "The aim of this study was the development of novel polysaccharide based films intended to be used as edible food packaging material. The films were prepared by solution casting method using highly methoxylated pectin (PEC) and poly(ethylene glycol) (PEG) of various molecular weights (400, 600 and 1000 gmol(-1)) in different ratios (5:1, 3:1 and 1:1). The film formation was supported by hydrogen bonding between PEC and PEG, which was evidenced by means of ATR-FTIR and NMR analysis. TGA revealed that generally PEG behaves like a pro-degrading agent for pectin, except in the case of PEC/PEG film with a ratio of 1:1. Furthermore, DSC thermograms indicated that PEG1000 exists as a separate phase in the pectin matrix while the formulations with PEG400 and PEG600 showed mainly amorphous morphology. The addition of PEG enhanced the plasticization of PEC films, as evidenced by progressive decreasing of the glass transition temperature values (T-g). The tensile test measurements showed that increasing concentration of PEG produced weaker and more flexibile films. Due to the increased molecular mobility, the pectin phase became more permeable to water vapor as the PEG concentration increased. The obtained results showed that the combination of both polymers resulted in interesting bio -inspired edible films with the potential to compete with commercially used synthetic package materials. (C) 2017 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Food Hydrocolloids",
title = "Edible blend films of pectin and poly(ethylene glycol): Preparation and physico-chemical evaluation",
volume = "77",
pages = "494-501",
doi = "10.1016/j.foodhyd.2017.10.027"
}

(2018). Edible blend films of pectin and poly(ethylene glycol): Preparation and physico-chemical evaluation. in Food Hydrocolloids
Elsevier., 77, 494-501.
https://doi.org/10.1016/j.foodhyd.2017.10.027

Edible blend films of pectin and poly(ethylene glycol): Preparation and physico-chemical evaluation. in Food Hydrocolloids. 2018;77:494-501.
doi:10.1016/j.foodhyd.2017.10.027 .

"Edible blend films of pectin and poly(ethylene glycol): Preparation and physico-chemical evaluation" in Food Hydrocolloids, 77 (2018):494-501,
https://doi.org/10.1016/j.foodhyd.2017.10.027 . .

TY  - JOUR
AU  - Šešlija, Sanja
AU  - Nešić, Aleksandra
AU  - Škorić, Marija
AU  - Krušić, Melina
AU  - Santagata, Gabriella
AU  - Malinconico, Mario
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7614
AB  - The present paper reports on pectin based films modified with carboxymethyl cellulose intended for food packaging. The films are prepared by solvent-casting method with different carboxymethyl cellulose content and cross-linker concentration (Ca 2+ ions) in the presence of glycerol as a plasticizer. FT-IR spectra of the prepared films propose that carboxyl group from pectin are mainly involved in interactions with CMC, whereas −OH groups are mainly involved in self-associated hydrogen bonding of neat polymers. Further, an addition of carboxymethyl cellulose improved mechanical properties compared to pure pectin films, while TGA analysis confirmed satisfying thermal stability regarding their potential application as packaging material. Finally, water vapor permeabi lity values are in the range of 1.32 × 10 −7 up to 2.03 × 10 −7 g/m h Pa. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
T2  - Macromolecular Symposia
T1  - Pectin/Carboxymethylcellulose Films as a Potential Food Packaging Material
VL  - 378
IS  - 1
DO  - 10.1002/masy.201600163
ER  - 

@article{
author = "Šešlija, Sanja and Nešić, Aleksandra and Škorić, Marija and Krušić, Melina and Santagata, Gabriella and Malinconico, Mario",
year = "2018",
abstract = "The present paper reports on pectin based films modified with carboxymethyl cellulose intended for food packaging. The films are prepared by solvent-casting method with different carboxymethyl cellulose content and cross-linker concentration (Ca 2+ ions) in the presence of glycerol as a plasticizer. FT-IR spectra of the prepared films propose that carboxyl group from pectin are mainly involved in interactions with CMC, whereas −OH groups are mainly involved in self-associated hydrogen bonding of neat polymers. Further, an addition of carboxymethyl cellulose improved mechanical properties compared to pure pectin films, while TGA analysis confirmed satisfying thermal stability regarding their potential application as packaging material. Finally, water vapor permeabi lity values are in the range of 1.32 × 10 −7 up to 2.03 × 10 −7 g/m h Pa. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
journal = "Macromolecular Symposia",
title = "Pectin/Carboxymethylcellulose Films as a Potential Food Packaging Material",
volume = "378",
number = "1",
doi = "10.1002/masy.201600163"
}

Šešlija, S., Nešić, A., Škorić, M., Krušić, M., Santagata, G.,& Malinconico, M.. (2018). Pectin/Carboxymethylcellulose Films as a Potential Food Packaging Material. in Macromolecular Symposia, 378(1).
https://doi.org/10.1002/masy.201600163

Šešlija S, Nešić A, Škorić M, Krušić M, Santagata G, Malinconico M. Pectin/Carboxymethylcellulose Films as a Potential Food Packaging Material. in Macromolecular Symposia. 2018;378(1).
doi:10.1002/masy.201600163 .

Šešlija, Sanja, Nešić, Aleksandra, Škorić, Marija, Krušić, Melina, Santagata, Gabriella, Malinconico, Mario, "Pectin/Carboxymethylcellulose Films as a Potential Food Packaging Material" in Macromolecular Symposia, 378, no. 1 (2018),
https://doi.org/10.1002/masy.201600163 . .

TY  - JOUR
AU  - Nešić, Aleksandra
AU  - Onjia, Antonije E.
AU  - Davidović, Slađana Z.
AU  - Dimitrijević, Suzana I.
AU  - Errico, Maria Emanuela
AU  - Santagata, Gabriella
AU  - Malinconico, Mario
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1385
AB  - In this study, pectin based films including different amounts of sodium alginate were prepared by casting method. All the films, with and without polyglycerol as plasticizer, were crosslinked with zinc ions in order to extend their potential functionality. The development of junction points, occurring during the crosslinking process with zinc ions, induced the increasing of free volume with following changing in chemico-physical properties of films. The inclusion of alginate in pectin based formulations improved the strength of zinc ions crosslinking network, whereas the addition of polyglycerol significantly improved mechanical performance. Finally, zinc-crosslinked films evidenced antimicrobial activity against the most common exploited pathogens: Staphylococcus Aureus, Escherichia Coli and Candida Albicans. These results suggest that zinc-crosslinked based films can be exploitable as novel bio-active biomaterials for protection and disinfection of medical devices. (C) 2016 Elsevier Ltd. All rights reserved.
T2  - Carbohydrate Polymers
T1  - Design of pectin-sodium alginate based films for potential healthcare application: Study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity
VL  - 157
SP  - 981
EP  - 990
DO  - 10.1016/j.carbpol.2016.10.054
ER  - 

@article{
author = "Nešić, Aleksandra and Onjia, Antonije E. and Davidović, Slađana Z. and Dimitrijević, Suzana I. and Errico, Maria Emanuela and Santagata, Gabriella and Malinconico, Mario",
year = "2017",
abstract = "In this study, pectin based films including different amounts of sodium alginate were prepared by casting method. All the films, with and without polyglycerol as plasticizer, were crosslinked with zinc ions in order to extend their potential functionality. The development of junction points, occurring during the crosslinking process with zinc ions, induced the increasing of free volume with following changing in chemico-physical properties of films. The inclusion of alginate in pectin based formulations improved the strength of zinc ions crosslinking network, whereas the addition of polyglycerol significantly improved mechanical performance. Finally, zinc-crosslinked films evidenced antimicrobial activity against the most common exploited pathogens: Staphylococcus Aureus, Escherichia Coli and Candida Albicans. These results suggest that zinc-crosslinked based films can be exploitable as novel bio-active biomaterials for protection and disinfection of medical devices. (C) 2016 Elsevier Ltd. All rights reserved.",
journal = "Carbohydrate Polymers",
title = "Design of pectin-sodium alginate based films for potential healthcare application: Study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity",
volume = "157",
pages = "981-990",
doi = "10.1016/j.carbpol.2016.10.054"
}

Nešić, A., Onjia, A. E., Davidović, S. Z., Dimitrijević, S. I., Errico, M. E., Santagata, G.,& Malinconico, M.. (2017). Design of pectin-sodium alginate based films for potential healthcare application: Study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity. in Carbohydrate Polymers, 157, 981-990.
https://doi.org/10.1016/j.carbpol.2016.10.054

Nešić A, Onjia AE, Davidović SZ, Dimitrijević SI, Errico ME, Santagata G, Malinconico M. Design of pectin-sodium alginate based films for potential healthcare application: Study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity. in Carbohydrate Polymers. 2017;157:981-990.
doi:10.1016/j.carbpol.2016.10.054 .

Nešić, Aleksandra, Onjia, Antonije E., Davidović, Slađana Z., Dimitrijević, Suzana I., Errico, Maria Emanuela, Santagata, Gabriella, Malinconico, Mario, "Design of pectin-sodium alginate based films for potential healthcare application: Study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity" in Carbohydrate Polymers, 157 (2017):981-990,
https://doi.org/10.1016/j.carbpol.2016.10.054 . .