TY  - JOUR
AU  - Ivković, Sanja
AU  - Koruga, Đuro
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13101
T2  - Neural Regeneration Research
T1  - Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease
VL  - 19
IS  - 8
SP  - 1641
EP  - 1642
DO  - 10.4103/1673-5374.389641
ER  - 

@article{
author = "Ivković, Sanja and Koruga, Đuro",
year = "2024",
journal = "Neural Regeneration Research",
title = "Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease",
volume = "19",
number = "8",
pages = "1641-1642",
doi = "10.4103/1673-5374.389641"
}

Ivković, S.,& Koruga, Đ.. (2024). Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease. in Neural Regeneration Research, 19(8), 1641-1642.
https://doi.org/10.4103/1673-5374.389641

Ivković S, Koruga Đ. Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease. in Neural Regeneration Research. 2024;19(8):1641-1642.
doi:10.4103/1673-5374.389641 .

Ivković, Sanja, Koruga, Đuro, "Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease" in Neural Regeneration Research, 19, no. 8 (2024):1641-1642,
https://doi.org/10.4103/1673-5374.389641 . .

TY  - JOUR
AU  - Perović, Milka
AU  - Ćirić, Jelena
AU  - Matović, Valentina
AU  - Srbovan, Maja
AU  - Koruga, Đuro
AU  - Kanazir, Selma
AU  - Ivković, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10854
AB  - Introduction In the present study, we assessed the effects of the hyper-harmonized-hydroxylated fullerene–water complex (3HFWC) on Alzheimer's disease (AD) neuropathological hallmarks in 5XFAD mice, an AD animal model. Methods The 3-week-old 5XFAD mice were exposed to 3HFWC water solution ad libitum for 3 months in the presymptomatic phase of pathology. The functional effects of the treatment were confirmed through near-infrared spectroscopy (NIRS) analysis through machine learning (ML) using artificial neural networks (ANNs) to classify the control and 3HFWC-treated brain tissue samples. The effects of 3HFWC treatment on amyloid-β (Aβ) accumulation, plaque formation, gliosis, and synaptic plasticity in cortical and hippocampal tissue were assessed. Results The 3HFWC treatment significantly decreased the amyloid-β plaque load in specific parts of the cerebral cortex. At the same time, 3HFWC treatment did not induce the activation of glia (astrocytes and microglia) nor did it negatively affect synaptic protein markers (GAP-43, synaptophysin, and PSD-95). Conclusion The obtained results point to the potential of 3HFWC, when applied in the presymptomatic phase of AD, to interfere with amyloid plaque formation without inducing AD-related pathological processes such as neuroinflammation, gliosis, and synaptic vulnerability.
T2  - CNS Neuroscience & Therapeutics
T1  - The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease
IS  - InPress
DO  - 10.1111/cns.14188
ER  - 

@article{
author = "Perović, Milka and Ćirić, Jelena and Matović, Valentina and Srbovan, Maja and Koruga, Đuro and Kanazir, Selma and Ivković, Sanja",
year = "2023",
abstract = "Introduction In the present study, we assessed the effects of the hyper-harmonized-hydroxylated fullerene–water complex (3HFWC) on Alzheimer's disease (AD) neuropathological hallmarks in 5XFAD mice, an AD animal model. Methods The 3-week-old 5XFAD mice were exposed to 3HFWC water solution ad libitum for 3 months in the presymptomatic phase of pathology. The functional effects of the treatment were confirmed through near-infrared spectroscopy (NIRS) analysis through machine learning (ML) using artificial neural networks (ANNs) to classify the control and 3HFWC-treated brain tissue samples. The effects of 3HFWC treatment on amyloid-β (Aβ) accumulation, plaque formation, gliosis, and synaptic plasticity in cortical and hippocampal tissue were assessed. Results The 3HFWC treatment significantly decreased the amyloid-β plaque load in specific parts of the cerebral cortex. At the same time, 3HFWC treatment did not induce the activation of glia (astrocytes and microglia) nor did it negatively affect synaptic protein markers (GAP-43, synaptophysin, and PSD-95). Conclusion The obtained results point to the potential of 3HFWC, when applied in the presymptomatic phase of AD, to interfere with amyloid plaque formation without inducing AD-related pathological processes such as neuroinflammation, gliosis, and synaptic vulnerability.",
journal = "CNS Neuroscience & Therapeutics",
title = "The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease",
number = "InPress",
doi = "10.1111/cns.14188"
}

Perović, M., Ćirić, J., Matović, V., Srbovan, M., Koruga, Đ., Kanazir, S.,& Ivković, S.. (2023). The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease. in CNS Neuroscience & Therapeutics(InPress).
https://doi.org/10.1111/cns.14188

Perović M, Ćirić J, Matović V, Srbovan M, Koruga Đ, Kanazir S, Ivković S. The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease. in CNS Neuroscience & Therapeutics. 2023;(InPress).
doi:10.1111/cns.14188 .

Perović, Milka, Ćirić, Jelena, Matović, Valentina, Srbovan, Maja, Koruga, Đuro, Kanazir, Selma, Ivković, Sanja, "The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease" in CNS Neuroscience & Therapeutics, no. InPress (2023),
https://doi.org/10.1111/cns.14188 . .