TY  - JOUR
AU  - Mitrović, Miloš
AU  - Stanković-Popović, Verica
AU  - Tolinački, Maja
AU  - Golić, Nataša
AU  - Soković Bajić, Svetlana
AU  - Veljović, Katarina
AU  - Nastasijević, Branislav J.
AU  - Soldatović, Ivan A.
AU  - Svorcan, Petar
AU  - Dimković, Nada
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10699
AB  - ObjectiveAltering dysbiotic gut flora through synbiotic supplementation has recently been recognized as a potential treatment strategy to reduce the levels of gut-derived uremic toxins and decrease inflammation. Assessing its efficacy and safety has been the main goal of our randomized, double-blind, placebo-controlled study.MethodsA total of 34 nondialyzed chronic kidney disease patients, aged ≥18 years, with an estimated glomerular filtration rate between 15 and 45 mL/minute, were randomized either to an intervention group (n = 17), receiving synbiotic (Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium lactis, 32 billion colony forming units per day plus 3.2 g of inulin), or control group (n = 17), receiving placebo during 12 weeks. The impact of treatment on the dynamic of serum levels of gut-derived uremic toxins, total serum indoxyl sulfate, p-cresyl sulfate, and trimethylamine N-oxide, was defined as the primary outcome of the study. Secondary outcomes included changes in the stool microbiome, serum interleukin-6 levels, high-sensitivity C-reactive protein, estimated glomerular filtration rate, albuminuria, diet, gastrointestinal symptom dynamics, and safety. Serum levels of uremic toxins were determined using ultraperformance liquid chromatography. The stool microbiome analysis was performed using the 16S ribosomal ribonucleic acid gene sequencing approach.ResultsSynbiotic treatment significantly modified gut microbiome with Bifidobacteria, Lactobacillus, and Subdoligranulum genera enrichment and consequently reduced serum level of indoxyl sulfate (ΔIS –21.5% vs. 5.3%, P < .001), improved estimated glomerular filtration rate (ΔeGFR 12% vs. 8%, P = .029), and decreased level of high-sensitivity C-reactive protein (–39.5 vs. –8.5%, P < .001) in treated patients. Two patients of the intervention arm complained of increased flatulence. No other safety issues were noted.ConclusionSynbiotics could be available, safe, and an effective therapeutic strategy we could use in daily practice in order to decrease levels of uremic toxins and microinflammation in chronic kidney disease patients.
T2  - Journal of Renal Nutrition
T1  - The impact of synbiotic treatment on the levels of gut-derived uremic zoxins, inflammation, and gut microbiome of chronic kidney disease patients - a randomized trial
VL  - 33
IS  - 2
SP  - 278
EP  - 288
DO  - 10.1053/j.jrn.2022.07.008
ER  - 

@article{
author = "Mitrović, Miloš and Stanković-Popović, Verica and Tolinački, Maja and Golić, Nataša and Soković Bajić, Svetlana and Veljović, Katarina and Nastasijević, Branislav J. and Soldatović, Ivan A. and Svorcan, Petar and Dimković, Nada",
year = "2023",
abstract = "ObjectiveAltering dysbiotic gut flora through synbiotic supplementation has recently been recognized as a potential treatment strategy to reduce the levels of gut-derived uremic toxins and decrease inflammation. Assessing its efficacy and safety has been the main goal of our randomized, double-blind, placebo-controlled study.MethodsA total of 34 nondialyzed chronic kidney disease patients, aged ≥18 years, with an estimated glomerular filtration rate between 15 and 45 mL/minute, were randomized either to an intervention group (n = 17), receiving synbiotic (Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium lactis, 32 billion colony forming units per day plus 3.2 g of inulin), or control group (n = 17), receiving placebo during 12 weeks. The impact of treatment on the dynamic of serum levels of gut-derived uremic toxins, total serum indoxyl sulfate, p-cresyl sulfate, and trimethylamine N-oxide, was defined as the primary outcome of the study. Secondary outcomes included changes in the stool microbiome, serum interleukin-6 levels, high-sensitivity C-reactive protein, estimated glomerular filtration rate, albuminuria, diet, gastrointestinal symptom dynamics, and safety. Serum levels of uremic toxins were determined using ultraperformance liquid chromatography. The stool microbiome analysis was performed using the 16S ribosomal ribonucleic acid gene sequencing approach.ResultsSynbiotic treatment significantly modified gut microbiome with Bifidobacteria, Lactobacillus, and Subdoligranulum genera enrichment and consequently reduced serum level of indoxyl sulfate (ΔIS –21.5% vs. 5.3%, P < .001), improved estimated glomerular filtration rate (ΔeGFR 12% vs. 8%, P = .029), and decreased level of high-sensitivity C-reactive protein (–39.5 vs. –8.5%, P < .001) in treated patients. Two patients of the intervention arm complained of increased flatulence. No other safety issues were noted.ConclusionSynbiotics could be available, safe, and an effective therapeutic strategy we could use in daily practice in order to decrease levels of uremic toxins and microinflammation in chronic kidney disease patients.",
journal = "Journal of Renal Nutrition",
title = "The impact of synbiotic treatment on the levels of gut-derived uremic zoxins, inflammation, and gut microbiome of chronic kidney disease patients - a randomized trial",
volume = "33",
number = "2",
pages = "278-288",
doi = "10.1053/j.jrn.2022.07.008"
}

Mitrović, M., Stanković-Popović, V., Tolinački, M., Golić, N., Soković Bajić, S., Veljović, K., Nastasijević, B. J., Soldatović, I. A., Svorcan, P.,& Dimković, N.. (2023). The impact of synbiotic treatment on the levels of gut-derived uremic zoxins, inflammation, and gut microbiome of chronic kidney disease patients - a randomized trial. in Journal of Renal Nutrition, 33(2), 278-288.
https://doi.org/10.1053/j.jrn.2022.07.008

Mitrović M, Stanković-Popović V, Tolinački M, Golić N, Soković Bajić S, Veljović K, Nastasijević BJ, Soldatović IA, Svorcan P, Dimković N. The impact of synbiotic treatment on the levels of gut-derived uremic zoxins, inflammation, and gut microbiome of chronic kidney disease patients - a randomized trial. in Journal of Renal Nutrition. 2023;33(2):278-288.
doi:10.1053/j.jrn.2022.07.008 .

Mitrović, Miloš, Stanković-Popović, Verica, Tolinački, Maja, Golić, Nataša, Soković Bajić, Svetlana, Veljović, Katarina, Nastasijević, Branislav J., Soldatović, Ivan A., Svorcan, Petar, Dimković, Nada, "The impact of synbiotic treatment on the levels of gut-derived uremic zoxins, inflammation, and gut microbiome of chronic kidney disease patients - a randomized trial" in Journal of Renal Nutrition, 33, no. 2 (2023):278-288,
https://doi.org/10.1053/j.jrn.2022.07.008 . .

TY  - CONF
AU  - Dekleva, Milica
AU  - Đurić, Tamara
AU  - Đorđević, Ana
AU  - Soldatović, Ivan A.
AU  - Stanković, Aleksandra
AU  - Stevanović, Angelina
AU  - Živković, Maja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10710
AB  - Cardiac remodeling after the first myocardial infarction (MI) appears to be more successful in women than in men, but more frequently associated with heart failure (HF) development. Galectin-3 expression is upregulated in remodeling and failing myocardium and circulatory level is activated in hypertrophy, fibrosis and inflammation.This study aimed to investigate the potential role of sex differences in the following: risk factors, structural and functional left ventricle (LV) changes, coronary angiography, expression of Galectin-3 and it's circulating level for HF occurrence during 6 months in patients after first MI.The prospective study included patients with the first MI treated with the primary percutaneous coronary intervention (p PCI) who underwent Doppler echocardiography within 2±1 days of MI and after 6 months. Relative LGALS-3 mRNA expression in peripheral blood were detected by TaqMan® technology. Expression and concentration of Galectin-3 was obtained by ELISA method. Presence of HF was confirmed by clinical examination and Doppler echocardiography. Assessment of p PCI and description of coronary angiography was performed at the patient's admission time.The study included 137 men and 44 women, who were significantly older (57.8 vs. 54.4, p=0.034), with higher LDL cholesterol (3.54±0.93 vs. 4.03±1.27, p=0.027) without differences among angiographic characteristics and medications. In the acute phase of MI, the significantly lower indexed LV volumes were found in women compared to men (EDLVI: 58.3 vs. 49.6, p<0.001, ESLVI: 33.84 vs. 26.83, p<0.001), but the grade of LV remodeling (delta LVDVI, delta LVESVI) during 6 months and changes in LV ejection fraction (deltaLVEF) were similar (p=ns). Incidence of LV hypertrophy and HF development was significantly higher in women 70% vs. 44.6%, p=0.034, 37.5% vs.19.3%, p=0.02). Females have had a higher degree of LV diastolic dysfunction (DD) in the early and late phase after MI (p=0.038, p=0.027). There were significant correlations between grade of DD and level of Gal-3 expression (p=0.001). The relative expression of LGALS-3 mRNA in peripheral blood was higher in females (p=0.007) with upregulation of circulating Gal-3 in females (44.66 vs. 16.30, p<0.001) and in HF patients (31.1 vs. 21.2, p=0.025).Sex specific actions such as LV hypertrophy, diastolic dysfunction, upregulation of Galectin-3 expression and higher circulating level may explain more incidence of HF in female. Difference in model and determinants of HF between men and women can be important for further therapy including Gelectin-3 inhibition.Type of funding sources: None.
C3  - European Heart Journal
T1  - Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3
VL  - 43
IS  - Supplement 2
SP  - ehac544.816
DO  - 10.1093/eurheartj/ehac544.816
ER  - 

@conference{
author = "Dekleva, Milica and Đurić, Tamara and Đorđević, Ana and Soldatović, Ivan A. and Stanković, Aleksandra and Stevanović, Angelina and Živković, Maja",
year = "2022",
abstract = "Cardiac remodeling after the first myocardial infarction (MI) appears to be more successful in women than in men, but more frequently associated with heart failure (HF) development. Galectin-3 expression is upregulated in remodeling and failing myocardium and circulatory level is activated in hypertrophy, fibrosis and inflammation.This study aimed to investigate the potential role of sex differences in the following: risk factors, structural and functional left ventricle (LV) changes, coronary angiography, expression of Galectin-3 and it's circulating level for HF occurrence during 6 months in patients after first MI.The prospective study included patients with the first MI treated with the primary percutaneous coronary intervention (p PCI) who underwent Doppler echocardiography within 2±1 days of MI and after 6 months. Relative LGALS-3 mRNA expression in peripheral blood were detected by TaqMan® technology. Expression and concentration of Galectin-3 was obtained by ELISA method. Presence of HF was confirmed by clinical examination and Doppler echocardiography. Assessment of p PCI and description of coronary angiography was performed at the patient's admission time.The study included 137 men and 44 women, who were significantly older (57.8 vs. 54.4, p=0.034), with higher LDL cholesterol (3.54±0.93 vs. 4.03±1.27, p=0.027) without differences among angiographic characteristics and medications. In the acute phase of MI, the significantly lower indexed LV volumes were found in women compared to men (EDLVI: 58.3 vs. 49.6, p<0.001, ESLVI: 33.84 vs. 26.83, p<0.001), but the grade of LV remodeling (delta LVDVI, delta LVESVI) during 6 months and changes in LV ejection fraction (deltaLVEF) were similar (p=ns). Incidence of LV hypertrophy and HF development was significantly higher in women 70% vs. 44.6%, p=0.034, 37.5% vs.19.3%, p=0.02). Females have had a higher degree of LV diastolic dysfunction (DD) in the early and late phase after MI (p=0.038, p=0.027). There were significant correlations between grade of DD and level of Gal-3 expression (p=0.001). The relative expression of LGALS-3 mRNA in peripheral blood was higher in females (p=0.007) with upregulation of circulating Gal-3 in females (44.66 vs. 16.30, p<0.001) and in HF patients (31.1 vs. 21.2, p=0.025).Sex specific actions such as LV hypertrophy, diastolic dysfunction, upregulation of Galectin-3 expression and higher circulating level may explain more incidence of HF in female. Difference in model and determinants of HF between men and women can be important for further therapy including Gelectin-3 inhibition.Type of funding sources: None.",
journal = "European Heart Journal",
title = "Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3",
volume = "43",
number = "Supplement 2",
pages = "ehac544.816",
doi = "10.1093/eurheartj/ehac544.816"
}

Dekleva, M., Đurić, T., Đorđević, A., Soldatović, I. A., Stanković, A., Stevanović, A.,& Živković, M.. (2022). Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3. in European Heart Journal, 43(Supplement 2), ehac544.816.
https://doi.org/10.1093/eurheartj/ehac544.816

Dekleva M, Đurić T, Đorđević A, Soldatović IA, Stanković A, Stevanović A, Živković M. Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3. in European Heart Journal. 2022;43(Supplement 2):ehac544.816.
doi:10.1093/eurheartj/ehac544.816 .

Dekleva, Milica, Đurić, Tamara, Đorđević, Ana, Soldatović, Ivan A., Stanković, Aleksandra, Stevanović, Angelina, Živković, Maja, "Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3" in European Heart Journal, 43, no. Supplement 2 (2022):ehac544.816,
https://doi.org/10.1093/eurheartj/ehac544.816 . .

TY  - JOUR
AU  - Marinković, Jelena
AU  - Marković, Tatjana
AU  - Nikolić, Biljana
AU  - Soldatović, Ivan A.
AU  - Ivanov, Marija
AU  - Ćirić, Ana
AU  - Soković, Marina D.
AU  - Marković, Dejan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9826
AB  - The study aimed to investigate the potency of Leptospermum petersonii, Eucalyptus citriodora, Pelargonium graveolens, and Pelargonium roseum essential oils (EOs) against Streptococcus sanguinis and Streptococcus salivarius dental isolates. To examine the variation in sensitivity among strains of different origin, isolates from symptomatic and asymptomatic root canal infections, as well as the reference, strains S. sanguinis ATCC 10556 and S. salivarius ATCC 9222 were used in the study. EOs were chemically characterised (GC/MS). Their antibacterial and antibiofilm properties were detected by microdilution and CV assay respectively. Statistical analysis was performed by One way ANOVA. Examined bacterial strains, regardless clinical or ATCC, exhibited the highest sensitivity to L. petersonii and E. citriodora EOs (MIC ranged 0.53±0.00 - 5.88±1.27 mg/ml and 0.08±0.03 - 9.37±1.25 mg/ml respectively), while two other EOs were less efficient. Comparison of MIC values showed that sensitivity of the isolates recovered from symptomatic infections was the least, while the susceptibility of asymptomatic isolates and especially of reference strains were higher. EO inhibition of biofilm formation differed between clinical isolates of S. salivarius and their reference strain. Inhibition was higher in the case of S. salivarius ATCC 9222 (84 %-89 %) in comparison to that of clinical isolates (24 %-75 %). Regardless of the strains tested, E. citriodora exhibited the highest antibiofilm potential. To conclude: L. petersonii induced notable antibacterial potential, while E. citriodora EO proved promising antibacterial and antibiofilm activity. Due to the variable sensitivity of the isolates to EOs, it is suggested to screen activity on a large number of strains, especially from symptomatic infections.
T2  - Journal of Essential Oil Bearing Plants
T1  - Antibacterial and Antibiofilm Potential of Leptospermum petersonii F.M.Bailey, Eucalyptus citriodora Hook., Pelargonium graveolens L’Hér. and Pelargonium roseum (Andrews) DC. Essential Oils Against Selected Dental Isolates
VL  - 24
IS  - 2
SP  - 304
EP  - 316
DO  - 10.1080/0972060X.2021.1899059
ER  - 

@article{
author = "Marinković, Jelena and Marković, Tatjana and Nikolić, Biljana and Soldatović, Ivan A. and Ivanov, Marija and Ćirić, Ana and Soković, Marina D. and Marković, Dejan",
year = "2021",
abstract = "The study aimed to investigate the potency of Leptospermum petersonii, Eucalyptus citriodora, Pelargonium graveolens, and Pelargonium roseum essential oils (EOs) against Streptococcus sanguinis and Streptococcus salivarius dental isolates. To examine the variation in sensitivity among strains of different origin, isolates from symptomatic and asymptomatic root canal infections, as well as the reference, strains S. sanguinis ATCC 10556 and S. salivarius ATCC 9222 were used in the study. EOs were chemically characterised (GC/MS). Their antibacterial and antibiofilm properties were detected by microdilution and CV assay respectively. Statistical analysis was performed by One way ANOVA. Examined bacterial strains, regardless clinical or ATCC, exhibited the highest sensitivity to L. petersonii and E. citriodora EOs (MIC ranged 0.53±0.00 - 5.88±1.27 mg/ml and 0.08±0.03 - 9.37±1.25 mg/ml respectively), while two other EOs were less efficient. Comparison of MIC values showed that sensitivity of the isolates recovered from symptomatic infections was the least, while the susceptibility of asymptomatic isolates and especially of reference strains were higher. EO inhibition of biofilm formation differed between clinical isolates of S. salivarius and their reference strain. Inhibition was higher in the case of S. salivarius ATCC 9222 (84 %-89 %) in comparison to that of clinical isolates (24 %-75 %). Regardless of the strains tested, E. citriodora exhibited the highest antibiofilm potential. To conclude: L. petersonii induced notable antibacterial potential, while E. citriodora EO proved promising antibacterial and antibiofilm activity. Due to the variable sensitivity of the isolates to EOs, it is suggested to screen activity on a large number of strains, especially from symptomatic infections.",
journal = "Journal of Essential Oil Bearing Plants",
title = "Antibacterial and Antibiofilm Potential of Leptospermum petersonii F.M.Bailey, Eucalyptus citriodora Hook., Pelargonium graveolens L’Hér. and Pelargonium roseum (Andrews) DC. Essential Oils Against Selected Dental Isolates",
volume = "24",
number = "2",
pages = "304-316",
doi = "10.1080/0972060X.2021.1899059"
}

Marinković, J., Marković, T., Nikolić, B., Soldatović, I. A., Ivanov, M., Ćirić, A., Soković, M. D.,& Marković, D.. (2021). Antibacterial and Antibiofilm Potential of Leptospermum petersonii F.M.Bailey, Eucalyptus citriodora Hook., Pelargonium graveolens L’Hér. and Pelargonium roseum (Andrews) DC. Essential Oils Against Selected Dental Isolates. in Journal of Essential Oil Bearing Plants, 24(2), 304-316.
https://doi.org/10.1080/0972060X.2021.1899059

Marinković J, Marković T, Nikolić B, Soldatović IA, Ivanov M, Ćirić A, Soković MD, Marković D. Antibacterial and Antibiofilm Potential of Leptospermum petersonii F.M.Bailey, Eucalyptus citriodora Hook., Pelargonium graveolens L’Hér. and Pelargonium roseum (Andrews) DC. Essential Oils Against Selected Dental Isolates. in Journal of Essential Oil Bearing Plants. 2021;24(2):304-316.
doi:10.1080/0972060X.2021.1899059 .

Marinković, Jelena, Marković, Tatjana, Nikolić, Biljana, Soldatović, Ivan A., Ivanov, Marija, Ćirić, Ana, Soković, Marina D., Marković, Dejan, "Antibacterial and Antibiofilm Potential of Leptospermum petersonii F.M.Bailey, Eucalyptus citriodora Hook., Pelargonium graveolens L’Hér. and Pelargonium roseum (Andrews) DC. Essential Oils Against Selected Dental Isolates" in Journal of Essential Oil Bearing Plants, 24, no. 2 (2021):304-316,
https://doi.org/10.1080/0972060X.2021.1899059 . .

TY  - JOUR
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatović, Ivan A.
AU  - Lukić, Iva
AU  - Andrić-Petrović, Sanja
AU  - Mirjanić, Tijana
AU  - Stanković, Biljana
AU  - Žukić, Branka
AU  - Željić, Katarina
AU  - Gašić, Vladimir
AU  - Novaković, Ivana
AU  - Pavlović, Sonja
AU  - Adžić, Miroslav
AU  - Marić, Nađa P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9748
AB  - Hypothalamic–pituitary–adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5 methylation in subjects with different genetic liability for psychosis. A total of 144 participants were included in the study: 48 patients with psychotic disorders, 50 unaffected siblings, and 46 healthy controls. CT was assessed by Childhood Trauma Questionnaire. The FKBP5 rs1360780 was genotyped and FKBP5 methylation analyses were performed using bisulfite conversion followed by Sanger sequencing at three CpG sites in intron 7. Mixed linear model was used to assess group differences depending on rs1360780 T allele and CT. Results showed a significant T allele-dependent decrease of FKBP5 methylation in patients compared to unaffected siblings and controls. Effect of interaction between T allele and CT exposure on FKBP5 demethylation was found in controls. No effect of both risk factors (T allele and CT) on FKBP5 methylation level was found in unaffected siblings. We confirmed previous evidence of the association between the FKBP5 rs1360780 T allele, CT, and decreased FKBP5 methylation in intron 7. Allele-specific FKBP5 demethylation found in patients could shed a light on altered HPA axis activity in a subgroup of patients related to stress-induced psychosis. FKBP5 methylation and potential protective mechanisms in unaffected siblings after trauma exposure require further investigation. © 2021 Elsevier Ltd
T2  - Psychoneuroendocrinology
T1  - The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls
VL  - 128
SP  - 105205
DO  - 10.1016/j.psyneuen.2021.105205
ER  - 

@article{
author = "Mihaljević, Marina and Franić, Dušanka and Soldatović, Ivan A. and Lukić, Iva and Andrić-Petrović, Sanja and Mirjanić, Tijana and Stanković, Biljana and Žukić, Branka and Željić, Katarina and Gašić, Vladimir and Novaković, Ivana and Pavlović, Sonja and Adžić, Miroslav and Marić, Nađa P.",
year = "2021",
abstract = "Hypothalamic–pituitary–adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5 methylation in subjects with different genetic liability for psychosis. A total of 144 participants were included in the study: 48 patients with psychotic disorders, 50 unaffected siblings, and 46 healthy controls. CT was assessed by Childhood Trauma Questionnaire. The FKBP5 rs1360780 was genotyped and FKBP5 methylation analyses were performed using bisulfite conversion followed by Sanger sequencing at three CpG sites in intron 7. Mixed linear model was used to assess group differences depending on rs1360780 T allele and CT. Results showed a significant T allele-dependent decrease of FKBP5 methylation in patients compared to unaffected siblings and controls. Effect of interaction between T allele and CT exposure on FKBP5 demethylation was found in controls. No effect of both risk factors (T allele and CT) on FKBP5 methylation level was found in unaffected siblings. We confirmed previous evidence of the association between the FKBP5 rs1360780 T allele, CT, and decreased FKBP5 methylation in intron 7. Allele-specific FKBP5 demethylation found in patients could shed a light on altered HPA axis activity in a subgroup of patients related to stress-induced psychosis. FKBP5 methylation and potential protective mechanisms in unaffected siblings after trauma exposure require further investigation. © 2021 Elsevier Ltd",
journal = "Psychoneuroendocrinology",
title = "The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls",
volume = "128",
pages = "105205",
doi = "10.1016/j.psyneuen.2021.105205"
}

Mihaljević, M., Franić, D., Soldatović, I. A., Lukić, I., Andrić-Petrović, S., Mirjanić, T., Stanković, B., Žukić, B., Željić, K., Gašić, V., Novaković, I., Pavlović, S., Adžić, M.,& Marić, N. P.. (2021). The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls. in Psychoneuroendocrinology, 128, 105205.
https://doi.org/10.1016/j.psyneuen.2021.105205

Mihaljević M, Franić D, Soldatović IA, Lukić I, Andrić-Petrović S, Mirjanić T, Stanković B, Žukić B, Željić K, Gašić V, Novaković I, Pavlović S, Adžić M, Marić NP. The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls. in Psychoneuroendocrinology. 2021;128:105205.
doi:10.1016/j.psyneuen.2021.105205 .

Mihaljević, Marina, Franić, Dušanka, Soldatović, Ivan A., Lukić, Iva, Andrić-Petrović, Sanja, Mirjanić, Tijana, Stanković, Biljana, Žukić, Branka, Željić, Katarina, Gašić, Vladimir, Novaković, Ivana, Pavlović, Sonja, Adžić, Miroslav, Marić, Nađa P., "The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls" in Psychoneuroendocrinology, 128 (2021):105205,
https://doi.org/10.1016/j.psyneuen.2021.105205 . .

TY  - JOUR
AU  - Paraš, Smiljana
AU  - Janković, Ognjenka
AU  - Trišić, Dijana
AU  - Čolović, Božana M.
AU  - Mitrović‐Ajtić, Olivera
AU  - Dekić, Radoslav
AU  - Soldatović, Ivan A.
AU  - Živković-Sandić, Marija
AU  - Živković, Slavoljub
AU  - Jokanović, Vukoman R.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8557
AB  - Aim: To examine the potential systemic toxicity of nanostructured materials based on calcium silicate and calcium aluminate, for potential application in Dentistry. Methodology: Twenty-four Albino Wistar rats aged 2 months were used as an in vivo animal model for subcutaneous implantation of the investigated materials, placed in polyethylene tubes. Thirty days after implantation, the livers of the rats were analysed and following histological and stereological parameters were evaluated for volume density of hepatocytes and blood sinusoids, number and numerical density of hepatocytes, surface of hepatocytes and their nucleuses, nucleocytoplasmic ratio and mitotic index of hepatocytes. Stereological measurements were achieved using Cavalieri's principle, with grid P2 and unbiased analysis. Additionally, immunohistochemistry studies were performed to further analyse changes in liver tissue. Several haematological and biochemical parameters of blood of experimental animals were also analysed, as well as local tissue reactions around the implants. Statistical analysis was performed using parametric (anova and t-test) and nonparametric tests (Kruskal–Wallis and Mann–Whitney U-test) depending on data distribution. Results: Implanted dental cements led to an increase in stereological and histological parameters in liver tissue compared to control rats. Although the investigated parameters mostly showed significant differences between control and experimental animals, the liver tissue of the experimental animals did not have visible signs of pathological changes. This was supported by the analysis of blood parameters which were not significantly different between control and experimental animals. Also, the subcutaneous tissues had minimal inflammatory reactions. Immunohistochemistry studies revealed that nanostructured materials induced proliferation of hepatocytes, but that the immunological response to the materials was not strong enough to induce proliferation of immunoreactive cells in liver in the observed time period. Conclusions: This study was performed as a contribution to the attestation of the biocompatibility of dental cements based on calcium silicate and calcium aluminate. Although these materials induced several changes in the liver structure, they were not clinically relevant and represent a normal and reversible response of the liver to the presence of biocompatible materials in the body. Blood and immunohistochemistry analyses and local tissue reactions further confirmed that these materials possess good biocompatible potential. © 2019 International Endodontic Journal. Published by John Wiley & Sons Ltd
T2  - International Endodontic Journal
T1  - Influence of nanostructured calcium aluminate and calcium silicate on the liver: histological and unbiased stereological analysis
SP  - 1162
EP  - 1172
DO  - 10.1111/iej.13105
ER  - 

@article{
author = "Paraš, Smiljana and Janković, Ognjenka and Trišić, Dijana and Čolović, Božana M. and Mitrović‐Ajtić, Olivera and Dekić, Radoslav and Soldatović, Ivan A. and Živković-Sandić, Marija and Živković, Slavoljub and Jokanović, Vukoman R.",
year = "2019",
abstract = "Aim: To examine the potential systemic toxicity of nanostructured materials based on calcium silicate and calcium aluminate, for potential application in Dentistry. Methodology: Twenty-four Albino Wistar rats aged 2 months were used as an in vivo animal model for subcutaneous implantation of the investigated materials, placed in polyethylene tubes. Thirty days after implantation, the livers of the rats were analysed and following histological and stereological parameters were evaluated for volume density of hepatocytes and blood sinusoids, number and numerical density of hepatocytes, surface of hepatocytes and their nucleuses, nucleocytoplasmic ratio and mitotic index of hepatocytes. Stereological measurements were achieved using Cavalieri's principle, with grid P2 and unbiased analysis. Additionally, immunohistochemistry studies were performed to further analyse changes in liver tissue. Several haematological and biochemical parameters of blood of experimental animals were also analysed, as well as local tissue reactions around the implants. Statistical analysis was performed using parametric (anova and t-test) and nonparametric tests (Kruskal–Wallis and Mann–Whitney U-test) depending on data distribution. Results: Implanted dental cements led to an increase in stereological and histological parameters in liver tissue compared to control rats. Although the investigated parameters mostly showed significant differences between control and experimental animals, the liver tissue of the experimental animals did not have visible signs of pathological changes. This was supported by the analysis of blood parameters which were not significantly different between control and experimental animals. Also, the subcutaneous tissues had minimal inflammatory reactions. Immunohistochemistry studies revealed that nanostructured materials induced proliferation of hepatocytes, but that the immunological response to the materials was not strong enough to induce proliferation of immunoreactive cells in liver in the observed time period. Conclusions: This study was performed as a contribution to the attestation of the biocompatibility of dental cements based on calcium silicate and calcium aluminate. Although these materials induced several changes in the liver structure, they were not clinically relevant and represent a normal and reversible response of the liver to the presence of biocompatible materials in the body. Blood and immunohistochemistry analyses and local tissue reactions further confirmed that these materials possess good biocompatible potential. © 2019 International Endodontic Journal. Published by John Wiley & Sons Ltd",
journal = "International Endodontic Journal",
title = "Influence of nanostructured calcium aluminate and calcium silicate on the liver: histological and unbiased stereological analysis",
pages = "1162-1172",
doi = "10.1111/iej.13105"
}

Paraš, S., Janković, O., Trišić, D., Čolović, B. M., Mitrović‐Ajtić, O., Dekić, R., Soldatović, I. A., Živković-Sandić, M., Živković, S.,& Jokanović, V. R.. (2019). Influence of nanostructured calcium aluminate and calcium silicate on the liver: histological and unbiased stereological analysis. in International Endodontic Journal, 1162-1172.
https://doi.org/10.1111/iej.13105

Paraš S, Janković O, Trišić D, Čolović BM, Mitrović‐Ajtić O, Dekić R, Soldatović IA, Živković-Sandić M, Živković S, Jokanović VR. Influence of nanostructured calcium aluminate and calcium silicate on the liver: histological and unbiased stereological analysis. in International Endodontic Journal. 2019;:1162-1172.
doi:10.1111/iej.13105 .

Paraš, Smiljana, Janković, Ognjenka, Trišić, Dijana, Čolović, Božana M., Mitrović‐Ajtić, Olivera, Dekić, Radoslav, Soldatović, Ivan A., Živković-Sandić, Marija, Živković, Slavoljub, Jokanović, Vukoman R., "Influence of nanostructured calcium aluminate and calcium silicate on the liver: histological and unbiased stereological analysis" in International Endodontic Journal (2019):1162-1172,
https://doi.org/10.1111/iej.13105 . .

TY  - JOUR
AU  - Adžić, Miroslav
AU  - Glavonić, Emilija
AU  - Nešić, Milica J.
AU  - Milosavljević, Minja
AU  - Mihaljević, Marina
AU  - Petrović, Zorica D.
AU  - Pavlović, Zorana
AU  - Brkić, Željka
AU  - Francija, Ester
AU  - Soldatović, Ivan A.
AU  - Mitić, Miloš
AU  - Radulović, Jelena
AU  - Marić, Nađa P.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8010
AB  - Childhood trauma (CT) increases the risk for psychopathology through disturbed acquisition and extinction of fear. The effects of CT are mediated by abnormalities of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor (GR). Since, the alterations in GRα translational isoforms have been documented in psychiatric disorders we sought to: 1) explore whether multiple GRα isoforms in the human peripheral blood mononuclear cells of two independent cohorts (whole cell n = 40; and nuclear extracts n = 43, adult subjects) mediate the effect of CT on negative affectivity (NA) measured by Depression, Anxiety and Stress Scales (DASS), and 2) examine their role/function during fear extinction in the animal model. In multiple regression analysis, CT, nuclear 40-kDa GRα their interactions and FKBP5 explained 22%–35% of variance in DASS scores. Structural equation modeling showed that CT had a significant direct effect on 40-kDa and DASS in both cohorts, and on the nuclear 25-kDa GRα. The association between 40-kDa and total DASS was significantly mediated by nuclear FKBP5, whereas on DASS anxiety, over FKBP5 in both cohorts and nuclear full length GRα. Nuclear 40-kDa GRα and its interaction with CT had a significant direct effect on DASS anxiety. In mice, the successful extinction learning was followed by nuclear translocation of 40-kDa GRα and induction of BDNF exon IV expression. Our data revealed that the association between CT and adult NA in non-clinical subjects is mediated by the GRα translational isoforms, in particular 40-kDa GRα and emphasized its role in fear extinction and neural plasticity. © 2018 Elsevier Inc.
T2  - Progress in Neuro-Psychopharmacology and Biological Psychiatry
T1  - Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states
VL  - 90
SP  - 288
EP  - 299
DO  - 10.1016/j.pnpbp.2018.12.011
ER  - 

@article{
author = "Adžić, Miroslav and Glavonić, Emilija and Nešić, Milica J. and Milosavljević, Minja and Mihaljević, Marina and Petrović, Zorica D. and Pavlović, Zorana and Brkić, Željka and Francija, Ester and Soldatović, Ivan A. and Mitić, Miloš and Radulović, Jelena and Marić, Nađa P.",
year = "2019",
abstract = "Childhood trauma (CT) increases the risk for psychopathology through disturbed acquisition and extinction of fear. The effects of CT are mediated by abnormalities of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor (GR). Since, the alterations in GRα translational isoforms have been documented in psychiatric disorders we sought to: 1) explore whether multiple GRα isoforms in the human peripheral blood mononuclear cells of two independent cohorts (whole cell n = 40; and nuclear extracts n = 43, adult subjects) mediate the effect of CT on negative affectivity (NA) measured by Depression, Anxiety and Stress Scales (DASS), and 2) examine their role/function during fear extinction in the animal model. In multiple regression analysis, CT, nuclear 40-kDa GRα their interactions and FKBP5 explained 22%–35% of variance in DASS scores. Structural equation modeling showed that CT had a significant direct effect on 40-kDa and DASS in both cohorts, and on the nuclear 25-kDa GRα. The association between 40-kDa and total DASS was significantly mediated by nuclear FKBP5, whereas on DASS anxiety, over FKBP5 in both cohorts and nuclear full length GRα. Nuclear 40-kDa GRα and its interaction with CT had a significant direct effect on DASS anxiety. In mice, the successful extinction learning was followed by nuclear translocation of 40-kDa GRα and induction of BDNF exon IV expression. Our data revealed that the association between CT and adult NA in non-clinical subjects is mediated by the GRα translational isoforms, in particular 40-kDa GRα and emphasized its role in fear extinction and neural plasticity. © 2018 Elsevier Inc.",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
title = "Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states",
volume = "90",
pages = "288-299",
doi = "10.1016/j.pnpbp.2018.12.011"
}

Adžić, M., Glavonić, E., Nešić, M. J., Milosavljević, M., Mihaljević, M., Petrović, Z. D., Pavlović, Z., Brkić, Ž., Francija, E., Soldatović, I. A., Mitić, M., Radulović, J.,& Marić, N. P.. (2019). Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states. in Progress in Neuro-Psychopharmacology and Biological Psychiatry, 90, 288-299.
https://doi.org/10.1016/j.pnpbp.2018.12.011

Adžić M, Glavonić E, Nešić MJ, Milosavljević M, Mihaljević M, Petrović ZD, Pavlović Z, Brkić Ž, Francija E, Soldatović IA, Mitić M, Radulović J, Marić NP. Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states. in Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019;90:288-299.
doi:10.1016/j.pnpbp.2018.12.011 .

Adžić, Miroslav, Glavonić, Emilija, Nešić, Milica J., Milosavljević, Minja, Mihaljević, Marina, Petrović, Zorica D., Pavlović, Zorana, Brkić, Željka, Francija, Ester, Soldatović, Ivan A., Mitić, Miloš, Radulović, Jelena, Marić, Nađa P., "Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states" in Progress in Neuro-Psychopharmacology and Biological Psychiatry, 90 (2019):288-299,
https://doi.org/10.1016/j.pnpbp.2018.12.011 . .

TY  - JOUR
AU  - Perović, Milan
AU  - Sudar-Milovanović, Emina
AU  - Simonović, Ema D.
AU  - Resanović, Ivana
AU  - Draganić, Veselin D.
AU  - Radaković, Jovana D.
AU  - Soldatović, Ivan A.
AU  - Isenović, Esma R.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0306987718310892
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8006
AB  - Controlled ovarian stimulation (COS) is used to augment the number of retrieved oocytes in in vitro fertilization (IVF). Follicular fluid (FF) contributes significantly to oocyte quality. Since the FF is composed of follicular secretions and plasma exudation, it reflects alterations in granulosa and thecal cells secretion as well as changes in the level of plasma constituents. Phospholipids (PL) and free fatty acids (FFA) are important constituents of both, FF and serum. Our hypothesis is that COS affects the level of PL and FFA in serum. Furthermore, since the level of PL and FFA in FF partially depends on their levels in serum, as a collaterally of our hypothesis is that the existing level of PL and FFA in serum correlates with the levels of PL and FFA in FF, and that the dose of applied gonadotropins during COS will correlate with the levels of PL and FFA in serum and FF. In addition, we assume that the level of PL and FFA in serum and in FF after COS will correlate with the retrieved number of GQ oocytes, one of the most important outcomes of COS.. © 2018
T2  - Medical Hypotheses
T1  - Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation
VL  - 123
SP  - 30
EP  - 34
DO  - 10.1016/j.mehy.2018.11.021
ER  - 

@article{
author = "Perović, Milan and Sudar-Milovanović, Emina and Simonović, Ema D. and Resanović, Ivana and Draganić, Veselin D. and Radaković, Jovana D. and Soldatović, Ivan A. and Isenović, Esma R.",
year = "2019",
abstract = "Controlled ovarian stimulation (COS) is used to augment the number of retrieved oocytes in in vitro fertilization (IVF). Follicular fluid (FF) contributes significantly to oocyte quality. Since the FF is composed of follicular secretions and plasma exudation, it reflects alterations in granulosa and thecal cells secretion as well as changes in the level of plasma constituents. Phospholipids (PL) and free fatty acids (FFA) are important constituents of both, FF and serum. Our hypothesis is that COS affects the level of PL and FFA in serum. Furthermore, since the level of PL and FFA in FF partially depends on their levels in serum, as a collaterally of our hypothesis is that the existing level of PL and FFA in serum correlates with the levels of PL and FFA in FF, and that the dose of applied gonadotropins during COS will correlate with the levels of PL and FFA in serum and FF. In addition, we assume that the level of PL and FFA in serum and in FF after COS will correlate with the retrieved number of GQ oocytes, one of the most important outcomes of COS.. © 2018",
journal = "Medical Hypotheses",
title = "Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation",
volume = "123",
pages = "30-34",
doi = "10.1016/j.mehy.2018.11.021"
}

Perović, M., Sudar-Milovanović, E., Simonović, E. D., Resanović, I., Draganić, V. D., Radaković, J. D., Soldatović, I. A.,& Isenović, E. R.. (2019). Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation. in Medical Hypotheses, 123, 30-34.
https://doi.org/10.1016/j.mehy.2018.11.021

Perović M, Sudar-Milovanović E, Simonović ED, Resanović I, Draganić VD, Radaković JD, Soldatović IA, Isenović ER. Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation. in Medical Hypotheses. 2019;123:30-34.
doi:10.1016/j.mehy.2018.11.021 .

Perović, Milan, Sudar-Milovanović, Emina, Simonović, Ema D., Resanović, Ivana, Draganić, Veselin D., Radaković, Jovana D., Soldatović, Ivan A., Isenović, Esma R., "Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation" in Medical Hypotheses, 123 (2019):30-34,
https://doi.org/10.1016/j.mehy.2018.11.021 . .

TY  - JOUR
AU  - Jokanović, Vukoman R.
AU  - Čolović, Božana M.
AU  - Marković, Dejan
AU  - Petrović, Milan
AU  - Soldatovic, Ivan
AU  - Antonijević, Đorđe
AU  - Milosavljević, Petar
AU  - Sjerobabin, Nikola
AU  - Sopta, Jelena
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1604
AB  - This study examined the potential of a new porous calcium hydroxyapatite scaffold covered with poly (lactide-co-glycolide) (PLGA) as a bone substitute, identifying its advantages over Geistlich Bio-Oss (R), considered the gold standard, in in vivo biofunctionality investigations. Structural and morphological properties of the new scaffold were analyzed by scanning electron and atomic force microscopy. The biofunctionality assays were performed on New Zealand white rabbits using new scaffold for filling full-thickness defects of critical size. The evaluated parameters were: the presence of macrophages, giant cells, monoocytes, plasma cells, granulocytes, neo-angiogenesis, fibroplasia, and the percentage of mineralization. Parallel biofunctionality assays were performed using Geistlich Bio-Oss (R). The appearance of bone defects 12 weeks after the new scaffold implantation showed the presence of a small number of typical immune response cells. Furthermore, significantly reduced number of capillary buds, low intensity of fibroplasia and high degree of mineralization in a lamellar pattern indicated that the inflammation process has been almost completely overcome and that the new bone formed was in the final phase of remodeling. All biofunctionality assays proved the new scaffolds suitability as a bone substitute for applications in maxillofacial surgery. It showed numerous biological advantages over Geistlich Bio-Oss (R) which was reflected mainly as a lower number of giant cells surrounding implanted material and higher degree of mineralization in new formed bone.
T2  - Biomedical Engineering / Biomedizinische Technik
T1  - Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation
VL  - 62
IS  - 3
SP  - 295
EP  - 306
DO  - 10.1515/bmt-2015-0164
ER  - 

@article{
author = "Jokanović, Vukoman R. and Čolović, Božana M. and Marković, Dejan and Petrović, Milan and Soldatovic, Ivan and Antonijević, Đorđe and Milosavljević, Petar and Sjerobabin, Nikola and Sopta, Jelena",
year = "2017",
abstract = "This study examined the potential of a new porous calcium hydroxyapatite scaffold covered with poly (lactide-co-glycolide) (PLGA) as a bone substitute, identifying its advantages over Geistlich Bio-Oss (R), considered the gold standard, in in vivo biofunctionality investigations. Structural and morphological properties of the new scaffold were analyzed by scanning electron and atomic force microscopy. The biofunctionality assays were performed on New Zealand white rabbits using new scaffold for filling full-thickness defects of critical size. The evaluated parameters were: the presence of macrophages, giant cells, monoocytes, plasma cells, granulocytes, neo-angiogenesis, fibroplasia, and the percentage of mineralization. Parallel biofunctionality assays were performed using Geistlich Bio-Oss (R). The appearance of bone defects 12 weeks after the new scaffold implantation showed the presence of a small number of typical immune response cells. Furthermore, significantly reduced number of capillary buds, low intensity of fibroplasia and high degree of mineralization in a lamellar pattern indicated that the inflammation process has been almost completely overcome and that the new bone formed was in the final phase of remodeling. All biofunctionality assays proved the new scaffolds suitability as a bone substitute for applications in maxillofacial surgery. It showed numerous biological advantages over Geistlich Bio-Oss (R) which was reflected mainly as a lower number of giant cells surrounding implanted material and higher degree of mineralization in new formed bone.",
journal = "Biomedical Engineering / Biomedizinische Technik",
title = "Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation",
volume = "62",
number = "3",
pages = "295-306",
doi = "10.1515/bmt-2015-0164"
}

Jokanović, V. R., Čolović, B. M., Marković, D., Petrović, M., Soldatovic, I., Antonijević, Đ., Milosavljević, P., Sjerobabin, N.,& Sopta, J.. (2017). Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation. in Biomedical Engineering / Biomedizinische Technik, 62(3), 295-306.
https://doi.org/10.1515/bmt-2015-0164

Jokanović VR, Čolović BM, Marković D, Petrović M, Soldatovic I, Antonijević Đ, Milosavljević P, Sjerobabin N, Sopta J. Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation. in Biomedical Engineering / Biomedizinische Technik. 2017;62(3):295-306.
doi:10.1515/bmt-2015-0164 .

Jokanović, Vukoman R., Čolović, Božana M., Marković, Dejan, Petrović, Milan, Soldatovic, Ivan, Antonijević, Đorđe, Milosavljević, Petar, Sjerobabin, Nikola, Sopta, Jelena, "Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation" in Biomedical Engineering / Biomedizinische Technik, 62, no. 3 (2017):295-306,
https://doi.org/10.1515/bmt-2015-0164 . .

TY  - CONF
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Mirjanic, Tijana
AU  - Novaković, Ivana
AU  - Adžić, Miroslav
AU  - Marić, Nađa
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7157
C3  - Schizophrenia Bulletin
T1  - Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls
VL  - 43
SP  - S195
EP  - S195
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7157
ER  - 

@conference{
author = "Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Mirjanic, Tijana and Novaković, Ivana and Adžić, Miroslav and Marić, Nađa",
year = "2017",
journal = "Schizophrenia Bulletin",
title = "Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls",
volume = "43",
pages = "S195-S195",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7157"
}

Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Mirjanic, T., Novaković, I., Adžić, M.,& Marić, N.. (2017). Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls. in Schizophrenia Bulletin, 43, S195-S195.
https://hdl.handle.net/21.15107/rcub_vinar_7157

Mihaljević M, Franić D, Soldatovic I, Andrić S, Mirjanic T, Novaković I, Adžić M, Marić N. Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls. in Schizophrenia Bulletin. 2017;43:S195-S195.
https://hdl.handle.net/21.15107/rcub_vinar_7157 .

Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Mirjanic, Tijana, Novaković, Ivana, Adžić, Miroslav, Marić, Nađa, "Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls" in Schizophrenia Bulletin, 43 (2017):S195-S195,
https://hdl.handle.net/21.15107/rcub_vinar_7157 .

TY  - CONF
AU  - Marić, Nađa
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Lukić, Iva
AU  - Mirjanic, Tijana
AU  - Stankovic, Biljana
AU  - Zukic, Branka
AU  - Dobricic, Valerija
AU  - Novaković, Ivana
AU  - Pavlović, Sonja
AU  - Adžić, Miroslav
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7156
C3  - Schizophrenia Bulletin
T1  - The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation
VL  - 43
SP  - S66
EP  - S66
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7156
ER  - 

@conference{
author = "Marić, Nađa and Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Lukić, Iva and Mirjanic, Tijana and Stankovic, Biljana and Zukic, Branka and Dobricic, Valerija and Novaković, Ivana and Pavlović, Sonja and Adžić, Miroslav",
year = "2017",
journal = "Schizophrenia Bulletin",
title = "The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation",
volume = "43",
pages = "S66-S66",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7156"
}

Marić, N., Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Lukić, I., Mirjanic, T., Stankovic, B., Zukic, B., Dobricic, V., Novaković, I., Pavlović, S.,& Adžić, M.. (2017). The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation. in Schizophrenia Bulletin, 43, S66-S66.
https://hdl.handle.net/21.15107/rcub_vinar_7156

Marić N, Mihaljević M, Franić D, Soldatovic I, Andrić S, Lukić I, Mirjanic T, Stankovic B, Zukic B, Dobricic V, Novaković I, Pavlović S, Adžić M. The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation. in Schizophrenia Bulletin. 2017;43:S66-S66.
https://hdl.handle.net/21.15107/rcub_vinar_7156 .

Marić, Nađa, Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Lukić, Iva, Mirjanic, Tijana, Stankovic, Biljana, Zukic, Branka, Dobricic, Valerija, Novaković, Ivana, Pavlović, Sonja, Adžić, Miroslav, "The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation" in Schizophrenia Bulletin, 43 (2017):S66-S66,
https://hdl.handle.net/21.15107/rcub_vinar_7156 .

TY  - CONF
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Mirjanic, Tijana
AU  - Novaković, Ivana
AU  - Adžić, Miroslav
AU  - Nadja, Maric
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7185
C3  - European Neuropsychopharmacology
T1  - Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions
VL  - 27
SP  - S461
EP  - S462
DO  - 10.1016/j.euroneuro.2016.09.535
ER  - 

@conference{
author = "Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Mirjanic, Tijana and Novaković, Ivana and Adžić, Miroslav and Nadja, Maric",
year = "2017",
journal = "European Neuropsychopharmacology",
title = "Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions",
volume = "27",
pages = "S461-S462",
doi = "10.1016/j.euroneuro.2016.09.535"
}

Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Mirjanic, T., Novaković, I., Adžić, M.,& Nadja, M.. (2017). Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions. in European Neuropsychopharmacology, 27, S461-S462.
https://doi.org/10.1016/j.euroneuro.2016.09.535

Mihaljević M, Franić D, Soldatovic I, Andrić S, Mirjanic T, Novaković I, Adžić M, Nadja M. Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions. in European Neuropsychopharmacology. 2017;27:S461-S462.
doi:10.1016/j.euroneuro.2016.09.535 .

Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Mirjanic, Tijana, Novaković, Ivana, Adžić, Miroslav, Nadja, Maric, "Fkbp5 Epigenetic Changes in Schizophrenia: Similarity to Stress-Related Conditions" in European Neuropsychopharmacology, 27 (2017):S461-S462,
https://doi.org/10.1016/j.euroneuro.2016.09.535 . .

TY  - CONF
AU  - Mihaljevic, M.
AU  - Franić, Dušanka
AU  - Soldatovic, I.
AU  - Andric, S.
AU  - Stankovic, B.
AU  - Zukic, B.
AU  - Pavlović, Suncan
AU  - Adžić, Miroslav
AU  - Maric, N.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7186
C3  - European Neuropsychopharmacology
T1  - Epigenetic signature of early trauma: differences in the FKBP5 DNA methylation levels among psychotic patients, their healthy siblings and controls
VL  - 27
SP  - S967
EP  - S968
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7186
ER  - 

@conference{
author = "Mihaljevic, M. and Franić, Dušanka and Soldatovic, I. and Andric, S. and Stankovic, B. and Zukic, B. and Pavlović, Suncan and Adžić, Miroslav and Maric, N.",
year = "2017",
journal = "European Neuropsychopharmacology",
title = "Epigenetic signature of early trauma: differences in the FKBP5 DNA methylation levels among psychotic patients, their healthy siblings and controls",
volume = "27",
pages = "S967-S968",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7186"
}

Mihaljevic, M., Franić, D., Soldatovic, I., Andric, S., Stankovic, B., Zukic, B., Pavlović, S., Adžić, M.,& Maric, N.. (2017). Epigenetic signature of early trauma: differences in the FKBP5 DNA methylation levels among psychotic patients, their healthy siblings and controls. in European Neuropsychopharmacology, 27, S967-S968.
https://hdl.handle.net/21.15107/rcub_vinar_7186

Mihaljevic M, Franić D, Soldatovic I, Andric S, Stankovic B, Zukic B, Pavlović S, Adžić M, Maric N. Epigenetic signature of early trauma: differences in the FKBP5 DNA methylation levels among psychotic patients, their healthy siblings and controls. in European Neuropsychopharmacology. 2017;27:S967-S968.
https://hdl.handle.net/21.15107/rcub_vinar_7186 .

Mihaljevic, M., Franić, Dušanka, Soldatovic, I., Andric, S., Stankovic, B., Zukic, B., Pavlović, Suncan, Adžić, Miroslav, Maric, N., "Epigenetic signature of early trauma: differences in the FKBP5 DNA methylation levels among psychotic patients, their healthy siblings and controls" in European Neuropsychopharmacology, 27 (2017):S967-S968,
https://hdl.handle.net/21.15107/rcub_vinar_7186 .

TY  - JOUR
AU  - Lukić, Iva
AU  - Mitić, Miloš
AU  - Soldatovic, Ivan
AU  - Jovičić, Milica
AU  - Marić, Nađa
AU  - Radulović, Jelena
AU  - Adžić, Miroslav
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/445
AB  - We have previously shown that patients with the major depressive disorder (MDD) exhibited elevated phosphorylation of the lymphocyte glucocorticoid receptor (GR) at serine 226 (S226). Here, we further analyse potential alterations of GR signalization in lymphocytes of MDD patients, i.e. the cytoplasmic/nuclear distribution of GR, levels of FK506-binding protein 5 (FKBP5) and glucocorticoid-induced leucine zipper (GILZ). The FKBP5 acts as an important regulator of GR activation, by decreasing ligand binding and impeding translocation of the receptor to the nucleus, while GILZ mediates glucocorticoid anti-inflammatory effects. Our result showed that the depressed patients had significantly higher GR levels in the cytoplasm compared to controls, which was accompanied by higher FKBP5 levels. Linear regression model demonstrated significantly higher correlation between FKBP5 and cytoplasmic GR than the presence of MDD itself or phosphorylation of nuclear GR at S226. There were no differences in the levels of GILZ isoforms. Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.
T2  - Journal of Molecular Neuroscience
T1  - Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients
VL  - 55
IS  - 4
SP  - 951
EP  - 958
DO  - 10.1007/s12031-014-0451-z
ER  - 

@article{
author = "Lukić, Iva and Mitić, Miloš and Soldatovic, Ivan and Jovičić, Milica and Marić, Nađa and Radulović, Jelena and Adžić, Miroslav",
year = "2015",
abstract = "We have previously shown that patients with the major depressive disorder (MDD) exhibited elevated phosphorylation of the lymphocyte glucocorticoid receptor (GR) at serine 226 (S226). Here, we further analyse potential alterations of GR signalization in lymphocytes of MDD patients, i.e. the cytoplasmic/nuclear distribution of GR, levels of FK506-binding protein 5 (FKBP5) and glucocorticoid-induced leucine zipper (GILZ). The FKBP5 acts as an important regulator of GR activation, by decreasing ligand binding and impeding translocation of the receptor to the nucleus, while GILZ mediates glucocorticoid anti-inflammatory effects. Our result showed that the depressed patients had significantly higher GR levels in the cytoplasm compared to controls, which was accompanied by higher FKBP5 levels. Linear regression model demonstrated significantly higher correlation between FKBP5 and cytoplasmic GR than the presence of MDD itself or phosphorylation of nuclear GR at S226. There were no differences in the levels of GILZ isoforms. Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.",
journal = "Journal of Molecular Neuroscience",
title = "Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients",
volume = "55",
number = "4",
pages = "951-958",
doi = "10.1007/s12031-014-0451-z"
}

Lukić, I., Mitić, M., Soldatovic, I., Jovičić, M., Marić, N., Radulović, J.,& Adžić, M.. (2015). Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients. in Journal of Molecular Neuroscience, 55(4), 951-958.
https://doi.org/10.1007/s12031-014-0451-z

Lukić I, Mitić M, Soldatovic I, Jovičić M, Marić N, Radulović J, Adžić M. Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients. in Journal of Molecular Neuroscience. 2015;55(4):951-958.
doi:10.1007/s12031-014-0451-z .

Lukić, Iva, Mitić, Miloš, Soldatovic, Ivan, Jovičić, Milica, Marić, Nađa, Radulović, Jelena, Adžić, Miroslav, "Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients" in Journal of Molecular Neuroscience, 55, no. 4 (2015):951-958,
https://doi.org/10.1007/s12031-014-0451-z . .

TY  - JOUR
AU  - Jovičić, Milica
AU  - Marić, Nađa P.
AU  - Soldatovic, Ivan
AU  - Lukić, Iva
AU  - Andrić, Sanja
AU  - Mihaljević, Marina
AU  - Pavlović, Zorana
AU  - Mitić, Miloš
AU  - Adžić, Miroslav
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/707
AB  - Objectives. To develop a structural equation model of negative affectivity (NA) that involves interaction of glucocorticoid receptor (GR) signaling, personality dimensions and recent stressful life events. Methods. Seventy participants -35 diagnosed with major depression and 35 healthy controls, were enrolled in the study. Morning plasma cortisol levels were determined by chemiluminescent immunometric assays. Molecular parameters (total nuclear and cytoplasmatic GR, nuclear GR phosphorylated at serine 211 (pGR-211) and at serine 226 (pGR-226) and cytoplasmic FKBP51) were analysed from peripheral blood lymphocytes by Western blot. NA, personality dimensions and stressful life events were assessed by self-report instruments. Results. GR signalling parameters had direct independent effect on measures of NA, with pGR-226 levels showing the strongest correlation, followed by FKBP51 and pGR-211 levels. Neuroticism and extraversion also demonstrated strong independent effect on NA, while recent stressful events did not predict NA directly, but demonstrated a significant effect on personality dimensions. Cortisol, total nuclear GR and total cytoplasmatic GR levels were excluded from the model due to non-significant correlations with NA. Conclusions. Negative affectivity is a transdiagnostic factor in vulnerability to affective disorders and possible therapeutic target. Molecular signature of negative affectivity should incorporate GR phosphorylation with other known biological underpinnings.
T2  - World Journal of Biological Psychiatry
T1  - The role of glucocorticoid receptor phosphorylation in the model of negative affective states
VL  - 16
IS  - 5
SP  - 301
EP  - 311
DO  - 10.3109/15622975.2014.1000375
ER  - 

@article{
author = "Jovičić, Milica and Marić, Nađa P. and Soldatovic, Ivan and Lukić, Iva and Andrić, Sanja and Mihaljević, Marina and Pavlović, Zorana and Mitić, Miloš and Adžić, Miroslav",
year = "2015",
abstract = "Objectives. To develop a structural equation model of negative affectivity (NA) that involves interaction of glucocorticoid receptor (GR) signaling, personality dimensions and recent stressful life events. Methods. Seventy participants -35 diagnosed with major depression and 35 healthy controls, were enrolled in the study. Morning plasma cortisol levels were determined by chemiluminescent immunometric assays. Molecular parameters (total nuclear and cytoplasmatic GR, nuclear GR phosphorylated at serine 211 (pGR-211) and at serine 226 (pGR-226) and cytoplasmic FKBP51) were analysed from peripheral blood lymphocytes by Western blot. NA, personality dimensions and stressful life events were assessed by self-report instruments. Results. GR signalling parameters had direct independent effect on measures of NA, with pGR-226 levels showing the strongest correlation, followed by FKBP51 and pGR-211 levels. Neuroticism and extraversion also demonstrated strong independent effect on NA, while recent stressful events did not predict NA directly, but demonstrated a significant effect on personality dimensions. Cortisol, total nuclear GR and total cytoplasmatic GR levels were excluded from the model due to non-significant correlations with NA. Conclusions. Negative affectivity is a transdiagnostic factor in vulnerability to affective disorders and possible therapeutic target. Molecular signature of negative affectivity should incorporate GR phosphorylation with other known biological underpinnings.",
journal = "World Journal of Biological Psychiatry",
title = "The role of glucocorticoid receptor phosphorylation in the model of negative affective states",
volume = "16",
number = "5",
pages = "301-311",
doi = "10.3109/15622975.2014.1000375"
}

Jovičić, M., Marić, N. P., Soldatovic, I., Lukić, I., Andrić, S., Mihaljević, M., Pavlović, Z., Mitić, M.,& Adžić, M.. (2015). The role of glucocorticoid receptor phosphorylation in the model of negative affective states. in World Journal of Biological Psychiatry, 16(5), 301-311.
https://doi.org/10.3109/15622975.2014.1000375

Jovičić M, Marić NP, Soldatovic I, Lukić I, Andrić S, Mihaljević M, Pavlović Z, Mitić M, Adžić M. The role of glucocorticoid receptor phosphorylation in the model of negative affective states. in World Journal of Biological Psychiatry. 2015;16(5):301-311.
doi:10.3109/15622975.2014.1000375 .

Jovičić, Milica, Marić, Nađa P., Soldatovic, Ivan, Lukić, Iva, Andrić, Sanja, Mihaljević, Marina, Pavlović, Zorana, Mitić, Miloš, Adžić, Miroslav, "The role of glucocorticoid receptor phosphorylation in the model of negative affective states" in World Journal of Biological Psychiatry, 16, no. 5 (2015):301-311,
https://doi.org/10.3109/15622975.2014.1000375 . .

TY  - JOUR
AU  - Matic, P.
AU  - Jolic, S.
AU  - Tanaskovic, S.
AU  - Soldatovic, I.
AU  - Katsiki, N.
AU  - Isenović, Esma R.
AU  - Radak, Đorđe J.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/614
AB  - We report the relations between comorbidities and chronic venous disease. In this cross-sectional study, information was gathered from 1679 Serbian patients. The majority (65.0%) of patients were women. Mild forms of chronic venous disease (clinical, etiologic, anatomic and pathophysiologic [CEAP] classification; C0s-C1) were more frequent in women (11.6%), while severe forms (CEAP C4-C6) were more commonly encountered in men (42.1%). The most frequent comorbidity was emphysema/chronic obstructive pulmonary disease in both groups (74.3% in males and 70.6% in females). For females, diabetes mellitus (P LT .005), arterial hypertension (P LT .000), and skeletal/joint diseases (P LT .042) were more commonly found in the C4 to C6 category. Both males and females, with severe form of chronic venous disease, may benefit from additional screening for comorbidities. Further studies are needed to clarify the nature of association among comorbidities and chronic venous disease.
T2  - Angiology
T1  - Chronic Venous Disease and Comorbidities
VL  - 66
IS  - 6
SP  - 539
EP  - 544
DO  - 10.1177/0003319714541988
ER  - 

@article{
author = "Matic, P. and Jolic, S. and Tanaskovic, S. and Soldatovic, I. and Katsiki, N. and Isenović, Esma R. and Radak, Đorđe J.",
year = "2015",
abstract = "We report the relations between comorbidities and chronic venous disease. In this cross-sectional study, information was gathered from 1679 Serbian patients. The majority (65.0%) of patients were women. Mild forms of chronic venous disease (clinical, etiologic, anatomic and pathophysiologic [CEAP] classification; C0s-C1) were more frequent in women (11.6%), while severe forms (CEAP C4-C6) were more commonly encountered in men (42.1%). The most frequent comorbidity was emphysema/chronic obstructive pulmonary disease in both groups (74.3% in males and 70.6% in females). For females, diabetes mellitus (P LT .005), arterial hypertension (P LT .000), and skeletal/joint diseases (P LT .042) were more commonly found in the C4 to C6 category. Both males and females, with severe form of chronic venous disease, may benefit from additional screening for comorbidities. Further studies are needed to clarify the nature of association among comorbidities and chronic venous disease.",
journal = "Angiology",
title = "Chronic Venous Disease and Comorbidities",
volume = "66",
number = "6",
pages = "539-544",
doi = "10.1177/0003319714541988"
}

Matic, P., Jolic, S., Tanaskovic, S., Soldatovic, I., Katsiki, N., Isenović, E. R.,& Radak, Đ. J.. (2015). Chronic Venous Disease and Comorbidities. in Angiology, 66(6), 539-544.
https://doi.org/10.1177/0003319714541988

Matic P, Jolic S, Tanaskovic S, Soldatovic I, Katsiki N, Isenović ER, Radak ĐJ. Chronic Venous Disease and Comorbidities. in Angiology. 2015;66(6):539-544.
doi:10.1177/0003319714541988 .

Matic, P., Jolic, S., Tanaskovic, S., Soldatovic, I., Katsiki, N., Isenović, Esma R., Radak, Đorđe J., "Chronic Venous Disease and Comorbidities" in Angiology, 66, no. 6 (2015):539-544,
https://doi.org/10.1177/0003319714541988 . .

TY  - JOUR
AU  - Lukić, Iva
AU  - Mitić, Miloš
AU  - Đorđević, Jelena D.
AU  - Tatalović, Nikola R.
AU  - Božović, Natalija
AU  - Soldatovic, Ivan
AU  - Mihaljević, Marina
AU  - Pavlović, Zorana
AU  - Radojčić, Marija
AU  - Marić, Nađa P.
AU  - Adžić, Miroslav
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/148
AB  - Background: Oxidative stress is reliably observed in major depressive disorder (MDD). However, molecular data on the principal cellular redox-sensitive transcriptional factors and the levels of their downstream-regulated antioxidant enzymes in MDD are scarce. Methods: In the peripheral blood mononuclear cells (PBMC) of subjects with a current episode of MDD (n = 30) and healthy controls (n = 35), we investigated alterations in the levels of redox-sensing nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein, its inhibitor Keap1, and nuclear factor-kappa B (NF-kappa B), along with their cognate downstream effectors, the antioxidant enzymes (AOEs): manganese and copper zinc superoxide dismutase (MnSOD and CuZnSOD, respectively), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR). Results: MDD subjects exhibited higher levels of Nrf2 and its regulator Keap1, as well as NF-kappa B in the cytoplasm of PBMC compared to controls. This state was further reflected by increased levels of MnSOD, CuZnSOD and CAT proteins and by the lack of correlation between MnSOD and CAT, which could indicate impaired oxidative detoxification capacity in MDD patients. Moreover, increased levels of MnSOD, CuZnSOD and CAT in MDD patients positively correlated with levels of Nrf2, while increased levels of SODs were also positively related to NF-kappa B. There were no differences regarding the levels of GPx and GLR proteins, but the ratio of GLR/GPx was reduced, suggesting diminished capacity of GPx in antioxidative defence in PBMC of MDD subjects. Conclusion: These data provide evidence that MDD is characterized by up-regulation of redox-sensitive transcriptional factors (Nrf2 and NF-kappa B) and AOEs (MnSOD, CuZnSOD and CAT), indicating pro-oxidative state in the PBMC of MDD patients. (C) 2014 S. Karger AG, Basel
T2  - Neuropsychobiology
T1  - Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients
VL  - 70
IS  - 1
SP  - 1
EP  - 9
DO  - 10.1159/000362841
ER  - 

@article{
author = "Lukić, Iva and Mitić, Miloš and Đorđević, Jelena D. and Tatalović, Nikola R. and Božović, Natalija and Soldatovic, Ivan and Mihaljević, Marina and Pavlović, Zorana and Radojčić, Marija and Marić, Nađa P. and Adžić, Miroslav",
year = "2014",
abstract = "Background: Oxidative stress is reliably observed in major depressive disorder (MDD). However, molecular data on the principal cellular redox-sensitive transcriptional factors and the levels of their downstream-regulated antioxidant enzymes in MDD are scarce. Methods: In the peripheral blood mononuclear cells (PBMC) of subjects with a current episode of MDD (n = 30) and healthy controls (n = 35), we investigated alterations in the levels of redox-sensing nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein, its inhibitor Keap1, and nuclear factor-kappa B (NF-kappa B), along with their cognate downstream effectors, the antioxidant enzymes (AOEs): manganese and copper zinc superoxide dismutase (MnSOD and CuZnSOD, respectively), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR). Results: MDD subjects exhibited higher levels of Nrf2 and its regulator Keap1, as well as NF-kappa B in the cytoplasm of PBMC compared to controls. This state was further reflected by increased levels of MnSOD, CuZnSOD and CAT proteins and by the lack of correlation between MnSOD and CAT, which could indicate impaired oxidative detoxification capacity in MDD patients. Moreover, increased levels of MnSOD, CuZnSOD and CAT in MDD patients positively correlated with levels of Nrf2, while increased levels of SODs were also positively related to NF-kappa B. There were no differences regarding the levels of GPx and GLR proteins, but the ratio of GLR/GPx was reduced, suggesting diminished capacity of GPx in antioxidative defence in PBMC of MDD subjects. Conclusion: These data provide evidence that MDD is characterized by up-regulation of redox-sensitive transcriptional factors (Nrf2 and NF-kappa B) and AOEs (MnSOD, CuZnSOD and CAT), indicating pro-oxidative state in the PBMC of MDD patients. (C) 2014 S. Karger AG, Basel",
journal = "Neuropsychobiology",
title = "Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients",
volume = "70",
number = "1",
pages = "1-9",
doi = "10.1159/000362841"
}

Lukić, I., Mitić, M., Đorđević, J. D., Tatalović, N. R., Božović, N., Soldatovic, I., Mihaljević, M., Pavlović, Z., Radojčić, M., Marić, N. P.,& Adžić, M.. (2014). Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients. in Neuropsychobiology, 70(1), 1-9.
https://doi.org/10.1159/000362841

Lukić I, Mitić M, Đorđević JD, Tatalović NR, Božović N, Soldatovic I, Mihaljević M, Pavlović Z, Radojčić M, Marić NP, Adžić M. Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients. in Neuropsychobiology. 2014;70(1):1-9.
doi:10.1159/000362841 .

Lukić, Iva, Mitić, Miloš, Đorđević, Jelena D., Tatalović, Nikola R., Božović, Natalija, Soldatovic, Ivan, Mihaljević, Marina, Pavlović, Zorana, Radojčić, Marija, Marić, Nađa P., Adžić, Miroslav, "Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients" in Neuropsychobiology, 70, no. 1 (2014):1-9,
https://doi.org/10.1159/000362841 . .

TY  - JOUR
AU  - Simić, Iva
AU  - Marić, Nađa P.
AU  - Mitić, Miloš
AU  - Soldatovic, Ivan
AU  - Pavlović, Zorana
AU  - Mihaljević, Marina
AU  - Andrić, Sanja
AU  - Radoičić, Marija B.
AU  - Adžić, Miroslav
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5340
AB  - The impaired glucocorticoid receptor (GR) signaling has long been considered one of the cornerstones in understanding the pathophysiology of depression. Since the phosphorylation of GR is very important for GR function, in this study we investigated whether GR phosphorylation at serine 211 (pGR-S211) and serine 226 (pGR-S226) is altered in patients with current episode of major depressive disorder (MDD). Particularly, in 30 MDD patients and 35 controls we assessed the levels of nuclear total GR (tGR), pGR-S211 and pGR-S226 in peripheral blood mononuclear cells (PBMC) using Western blot technique, along with plasma cortisol concentrations from the same blood samples. Our results demonstrated increased phosphorylation of GR at S226 (p LT 0.001) and, to a less extent, at S211 (p LT 0.05) in MDD patients compared to controls. Consequently, the pGR-S211/pGR-S226 ratio was decreased (p LT 0.05) implying reduced transcriptional activity of GR in MDD patients. MDD subjects had higher cortisol levels than controls and cortisol concentrations were positively correlated with PBMC pGR-S226 levels from the same blood samples. There was no difference in the levels of tGR between MDD and control subjects. The study showed that altered phosphorylation of GR could contribute to impaired GR function related to the pathophysiology of depression. (c) 2012 Elsevier Inc. All rights reserved.
T2  - Progress in Neuro-psychopharmacology and Biological Psychiatry
T1  - Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder
VL  - 40
SP  - 281
EP  - 285
DO  - 10.1016/j.pnpbp.2012.10.021
ER  - 

@article{
author = "Simić, Iva and Marić, Nađa P. and Mitić, Miloš and Soldatovic, Ivan and Pavlović, Zorana and Mihaljević, Marina and Andrić, Sanja and Radoičić, Marija B. and Adžić, Miroslav",
year = "2013",
abstract = "The impaired glucocorticoid receptor (GR) signaling has long been considered one of the cornerstones in understanding the pathophysiology of depression. Since the phosphorylation of GR is very important for GR function, in this study we investigated whether GR phosphorylation at serine 211 (pGR-S211) and serine 226 (pGR-S226) is altered in patients with current episode of major depressive disorder (MDD). Particularly, in 30 MDD patients and 35 controls we assessed the levels of nuclear total GR (tGR), pGR-S211 and pGR-S226 in peripheral blood mononuclear cells (PBMC) using Western blot technique, along with plasma cortisol concentrations from the same blood samples. Our results demonstrated increased phosphorylation of GR at S226 (p LT 0.001) and, to a less extent, at S211 (p LT 0.05) in MDD patients compared to controls. Consequently, the pGR-S211/pGR-S226 ratio was decreased (p LT 0.05) implying reduced transcriptional activity of GR in MDD patients. MDD subjects had higher cortisol levels than controls and cortisol concentrations were positively correlated with PBMC pGR-S226 levels from the same blood samples. There was no difference in the levels of tGR between MDD and control subjects. The study showed that altered phosphorylation of GR could contribute to impaired GR function related to the pathophysiology of depression. (c) 2012 Elsevier Inc. All rights reserved.",
journal = "Progress in Neuro-psychopharmacology and Biological Psychiatry",
title = "Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder",
volume = "40",
pages = "281-285",
doi = "10.1016/j.pnpbp.2012.10.021"
}

Simić, I., Marić, N. P., Mitić, M., Soldatovic, I., Pavlović, Z., Mihaljević, M., Andrić, S., Radoičić, M. B.,& Adžić, M.. (2013). Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder. in Progress in Neuro-psychopharmacology and Biological Psychiatry, 40, 281-285.
https://doi.org/10.1016/j.pnpbp.2012.10.021

Simić I, Marić NP, Mitić M, Soldatovic I, Pavlović Z, Mihaljević M, Andrić S, Radoičić MB, Adžić M. Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder. in Progress in Neuro-psychopharmacology and Biological Psychiatry. 2013;40:281-285.
doi:10.1016/j.pnpbp.2012.10.021 .

Simić, Iva, Marić, Nađa P., Mitić, Miloš, Soldatovic, Ivan, Pavlović, Zorana, Mihaljević, Marina, Andrić, Sanja, Radoičić, Marija B., Adžić, Miroslav, "Phosphorylation of leukocyte glucocorticoid receptor in patients with current episode of major depressive disorder" in Progress in Neuro-psychopharmacology and Biological Psychiatry, 40 (2013):281-285,
https://doi.org/10.1016/j.pnpbp.2012.10.021 . .

TY  - CONF
AU  - Marić, N. P.
AU  - Simić, Iva
AU  - Pavlović, Z.
AU  - Mitić, Miloš
AU  - Soldatović, I.
AU  - Andrić, S.
AU  - Mihaljević, M.
AU  - Radojčić, Marija
AU  - Adžić, Miroslav
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5988
C3  - European Psychiatry
T1  - Phosphorylation of Peripheral Glucocorticoid Receptor in the Continuum from Current Depressive Episode to Vulnerability to Depression
VL  - 28
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5988
ER  - 

@conference{
author = "Marić, N. P. and Simić, Iva and Pavlović, Z. and Mitić, Miloš and Soldatović, I. and Andrić, S. and Mihaljević, M. and Radojčić, Marija and Adžić, Miroslav",
year = "2013",
journal = "European Psychiatry",
title = "Phosphorylation of Peripheral Glucocorticoid Receptor in the Continuum from Current Depressive Episode to Vulnerability to Depression",
volume = "28",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5988"
}

Marić, N. P., Simić, I., Pavlović, Z., Mitić, M., Soldatović, I., Andrić, S., Mihaljević, M., Radojčić, M.,& Adžić, M.. (2013). Phosphorylation of Peripheral Glucocorticoid Receptor in the Continuum from Current Depressive Episode to Vulnerability to Depression. in European Psychiatry, 28.
https://hdl.handle.net/21.15107/rcub_vinar_5988

Marić NP, Simić I, Pavlović Z, Mitić M, Soldatović I, Andrić S, Mihaljević M, Radojčić M, Adžić M. Phosphorylation of Peripheral Glucocorticoid Receptor in the Continuum from Current Depressive Episode to Vulnerability to Depression. in European Psychiatry. 2013;28.
https://hdl.handle.net/21.15107/rcub_vinar_5988 .

Marić, N. P., Simić, Iva, Pavlović, Z., Mitić, Miloš, Soldatović, I., Andrić, S., Mihaljević, M., Radojčić, Marija, Adžić, Miroslav, "Phosphorylation of Peripheral Glucocorticoid Receptor in the Continuum from Current Depressive Episode to Vulnerability to Depression" in European Psychiatry, 28 (2013),
https://hdl.handle.net/21.15107/rcub_vinar_5988 .

TY  - JOUR
AU  - Simić, Iva
AU  - Adžić, Miroslav
AU  - Marić, Nađa
AU  - Savić, Danka A.
AU  - Đorđević, Jelena D.
AU  - Mihaljević, Marina
AU  - Mitić, Miloš
AU  - Pavlović, Zorana
AU  - Soldatovic, Ivan
AU  - Krstić-Demonacos, Marija
AU  - Jasovic-Gasic, Miroslava
AU  - Radoičić, Marija B.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5753
AB  - The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - Psychiatry Research
T1  - A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults
VL  - 209
IS  - 3
SP  - 658
EP  - 664
DO  - 10.1016/j.psychres.2013.02.002
ER  - 

@article{
author = "Simić, Iva and Adžić, Miroslav and Marić, Nađa and Savić, Danka A. and Đorđević, Jelena D. and Mihaljević, Marina and Mitić, Miloš and Pavlović, Zorana and Soldatovic, Ivan and Krstić-Demonacos, Marija and Jasovic-Gasic, Miroslava and Radoičić, Marija B.",
year = "2013",
abstract = "The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "Psychiatry Research",
title = "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults",
volume = "209",
number = "3",
pages = "658-664",
doi = "10.1016/j.psychres.2013.02.002"
}

Simić, I., Adžić, M., Marić, N., Savić, D. A., Đorđević, J. D., Mihaljević, M., Mitić, M., Pavlović, Z., Soldatovic, I., Krstić-Demonacos, M., Jasovic-Gasic, M.,& Radoičić, M. B.. (2013). A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research, 209(3), 658-664.
https://doi.org/10.1016/j.psychres.2013.02.002

Simić I, Adžić M, Marić N, Savić DA, Đorđević JD, Mihaljević M, Mitić M, Pavlović Z, Soldatovic I, Krstić-Demonacos M, Jasovic-Gasic M, Radoičić MB. A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research. 2013;209(3):658-664.
doi:10.1016/j.psychres.2013.02.002 .

Simić, Iva, Adžić, Miroslav, Marić, Nađa, Savić, Danka A., Đorđević, Jelena D., Mihaljević, Marina, Mitić, Miloš, Pavlović, Zorana, Soldatovic, Ivan, Krstić-Demonacos, Marija, Jasovic-Gasic, Miroslava, Radoičić, Marija B., "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults" in Psychiatry Research, 209, no. 3 (2013):658-664,
https://doi.org/10.1016/j.psychres.2013.02.002 . .

TY  - CONF
AU  - Maric, N. P.
AU  - Simić, Iva
AU  - Adžić, Miroslav
AU  - Savić, Danka A.
AU  - Đorđević, Jelena D.
AU  - Mihaljevic, M.
AU  - Mitić, Miloš
AU  - Pavlović, Z.
AU  - Soldatovic, I.
AU  - Krstić-Demonacos, Marija
AU  - Jasovic-Gasic, M.
AU  - Radojčić, Marija
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4969
C3  - European Psychiatry
T1  - Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men
VL  - 27
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4969
ER  - 

@conference{
author = "Maric, N. P. and Simić, Iva and Adžić, Miroslav and Savić, Danka A. and Đorđević, Jelena D. and Mihaljevic, M. and Mitić, Miloš and Pavlović, Z. and Soldatovic, I. and Krstić-Demonacos, Marija and Jasovic-Gasic, M. and Radojčić, Marija",
year = "2012",
journal = "European Psychiatry",
title = "Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men",
volume = "27",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4969"
}

Maric, N. P., Simić, I., Adžić, M., Savić, D. A., Đorđević, J. D., Mihaljevic, M., Mitić, M., Pavlović, Z., Soldatovic, I., Krstić-Demonacos, M., Jasovic-Gasic, M.,& Radojčić, M.. (2012). Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men. in European Psychiatry, 27.
https://hdl.handle.net/21.15107/rcub_vinar_4969

Maric NP, Simić I, Adžić M, Savić DA, Đorđević JD, Mihaljevic M, Mitić M, Pavlović Z, Soldatovic I, Krstić-Demonacos M, Jasovic-Gasic M, Radojčić M. Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men. in European Psychiatry. 2012;27.
https://hdl.handle.net/21.15107/rcub_vinar_4969 .

Maric, N. P., Simić, Iva, Adžić, Miroslav, Savić, Danka A., Đorđević, Jelena D., Mihaljevic, M., Mitić, Miloš, Pavlović, Z., Soldatovic, I., Krstić-Demonacos, Marija, Jasovic-Gasic, M., Radojčić, Marija, "Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men" in European Psychiatry, 27 (2012),
https://hdl.handle.net/21.15107/rcub_vinar_4969 .