TY  - JOUR
AU  - Ilinčić, Branislava
AU  - Tomić Naglić, Dragana
AU  - Čabarkapa, Velibor
AU  - Bajkin, Ivana
AU  - Plećaš Đurić, Aleksandra
AU  - Kolarski, Ivor
AU  - Bojović, Marko
AU  - Urošević, Ivana
AU  - Stokić, E.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11569
AB  - Objective: Hypovitaminosis D may be associated with an increased susceptibility to infection, more severe COVID-19 forms, and a higher risk of death. The objective of this study was to investigate any possible connections between vitamin D status [as measured by serum 25-hydroxyvitamin D (25(OH)D) levels] and COVID-19 severity.  Patients and methods: In 2021, a cross-sectional study of consecutive adult COVID-19 patients was conducted. Anthropometric data, comorbidities, hospital setting, length of stay, respiratory support, outcome data, and vitamin D status were all evaluated.  Results: The length of hospitalization among participants (n = 74; mean age 57.64 ± 17.83 years, 55.4% male) was 18.58 ± 10 days, the majority of the hospital setting was a medical ward (67.6%), and the respiratory support in the form of mechanical ventilation was represented by 12.2%. Hypertension (54.1%), obesity (64.9%), and overweight (64.9%) were the most common cardiometabolic risk factors. In the study group, 44.6% of participants had severe vitamin D deficiency (< 30 nmol/l), while 8.1% had vitamin D insufficiency (50 - 74.9 nmol/l). Furthermore, patients with severe COVID-19 (semi-intensive care unit, intensive care unit) had significantly lower serum 25(OH)D levels (32.9 vs. 20.5 nmol/l; p = 0.007). Participants with severe vitamin D deficiency were older and had more prevalent hypertension, requiring mechanical ventilation; 24.2% experienced a fatal outcome.  Conclusions: Severe vitamin D deficiency may contribute significantly to the influence of other cardiometabolic risk factors in COVID-19.
T2  - European review for medical and pharmacological sciences
T1  - Association between vitamin D hypovitaminosis and severe forms of COVID-19
VL  - 27
IS  - 11
SP  - 5318
EP  - 5326
DO  - 10.26355/eurrev_202306_32651
ER  - 

@article{
author = "Ilinčić, Branislava and Tomić Naglić, Dragana and Čabarkapa, Velibor and Bajkin, Ivana and Plećaš Đurić, Aleksandra and Kolarski, Ivor and Bojović, Marko and Urošević, Ivana and Stokić, E. and Isenović, Esma R.",
year = "2023",
abstract = "Objective: Hypovitaminosis D may be associated with an increased susceptibility to infection, more severe COVID-19 forms, and a higher risk of death. The objective of this study was to investigate any possible connections between vitamin D status [as measured by serum 25-hydroxyvitamin D (25(OH)D) levels] and COVID-19 severity.  Patients and methods: In 2021, a cross-sectional study of consecutive adult COVID-19 patients was conducted. Anthropometric data, comorbidities, hospital setting, length of stay, respiratory support, outcome data, and vitamin D status were all evaluated.  Results: The length of hospitalization among participants (n = 74; mean age 57.64 ± 17.83 years, 55.4% male) was 18.58 ± 10 days, the majority of the hospital setting was a medical ward (67.6%), and the respiratory support in the form of mechanical ventilation was represented by 12.2%. Hypertension (54.1%), obesity (64.9%), and overweight (64.9%) were the most common cardiometabolic risk factors. In the study group, 44.6% of participants had severe vitamin D deficiency (< 30 nmol/l), while 8.1% had vitamin D insufficiency (50 - 74.9 nmol/l). Furthermore, patients with severe COVID-19 (semi-intensive care unit, intensive care unit) had significantly lower serum 25(OH)D levels (32.9 vs. 20.5 nmol/l; p = 0.007). Participants with severe vitamin D deficiency were older and had more prevalent hypertension, requiring mechanical ventilation; 24.2% experienced a fatal outcome.  Conclusions: Severe vitamin D deficiency may contribute significantly to the influence of other cardiometabolic risk factors in COVID-19.",
journal = "European review for medical and pharmacological sciences",
title = "Association between vitamin D hypovitaminosis and severe forms of COVID-19",
volume = "27",
number = "11",
pages = "5318-5326",
doi = "10.26355/eurrev_202306_32651"
}

Ilinčić, B., Tomić Naglić, D., Čabarkapa, V., Bajkin, I., Plećaš Đurić, A., Kolarski, I., Bojović, M., Urošević, I., Stokić, E.,& Isenović, E. R.. (2023). Association between vitamin D hypovitaminosis and severe forms of COVID-19. in European review for medical and pharmacological sciences, 27(11), 5318-5326.
https://doi.org/10.26355/eurrev_202306_32651

Ilinčić B, Tomić Naglić D, Čabarkapa V, Bajkin I, Plećaš Đurić A, Kolarski I, Bojović M, Urošević I, Stokić E, Isenović ER. Association between vitamin D hypovitaminosis and severe forms of COVID-19. in European review for medical and pharmacological sciences. 2023;27(11):5318-5326.
doi:10.26355/eurrev_202306_32651 .

Ilinčić, Branislava, Tomić Naglić, Dragana, Čabarkapa, Velibor, Bajkin, Ivana, Plećaš Đurić, Aleksandra, Kolarski, Ivor, Bojović, Marko, Urošević, Ivana, Stokić, E., Isenović, Esma R., "Association between vitamin D hypovitaminosis and severe forms of COVID-19" in European review for medical and pharmacological sciences, 27, no. 11 (2023):5318-5326,
https://doi.org/10.26355/eurrev_202306_32651 . .