TY  - JOUR
AU  - Antić, Katarina M.
AU  - Babić, Marija M.
AU  - Vuković, Jovana S.
AU  - Onjia, Antonije E.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida Lj.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1394
AB  - A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) hydrogel showed the most pronounced sorption toward Pb2+ from environment containing Cu2+, Zn2+, Cd2+, Ni2+ and Co2+. Sorption/desorption experiments, showed that the P(HEA/IA) hydrogels could be reused without significant loss of the initial properties even after three adsorption-desorption cycles.
T2  - Hemijska industrija
T1  - Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels
VL  - 70
IS  - 6
SP  - 695
EP  - 705
DO  - 10.2298/HEMIND151225006A
ER  - 

@article{
author = "Antić, Katarina M. and Babić, Marija M. and Vuković, Jovana S. and Onjia, Antonije E. and Filipović, Jovanka M. and Tomić, Simonida Lj.",
year = "2016",
abstract = "A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) hydrogel showed the most pronounced sorption toward Pb2+ from environment containing Cu2+, Zn2+, Cd2+, Ni2+ and Co2+. Sorption/desorption experiments, showed that the P(HEA/IA) hydrogels could be reused without significant loss of the initial properties even after three adsorption-desorption cycles.",
journal = "Hemijska industrija",
title = "Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels",
volume = "70",
number = "6",
pages = "695-705",
doi = "10.2298/HEMIND151225006A"
}

Antić, K. M., Babić, M. M., Vuković, J. S., Onjia, A. E., Filipović, J. M.,& Tomić, S. Lj.. (2016). Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels. in Hemijska industrija, 70(6), 695-705.
https://doi.org/10.2298/HEMIND151225006A

Antić KM, Babić MM, Vuković JS, Onjia AE, Filipović JM, Tomić SL. Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels. in Hemijska industrija. 2016;70(6):695-705.
doi:10.2298/HEMIND151225006A .

Antić, Katarina M., Babić, Marija M., Vuković, Jovana S., Onjia, Antonije E., Filipović, Jovanka M., Tomić, Simonida Lj., "Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels" in Hemijska industrija, 70, no. 6 (2016):695-705,
https://doi.org/10.2298/HEMIND151225006A . .

TY  - JOUR
AU  - Antić, Katarina M.
AU  - Babić, Marija M.
AU  - Vuković Jovasević, Jovana
AU  - Vasiljević-Radović, Dana
AU  - Onjia, Antonije E.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida Lj.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/467
AB  - Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal. (C) 2015 Elsevier B.V. All rights reserved.
T2  - Applied Surface Science
T1  - Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution
VL  - 338
SP  - 178
EP  - 189
DO  - 10.1016/j.apsusc.2015.02.133
ER  - 

@article{
author = "Antić, Katarina M. and Babić, Marija M. and Vuković Jovasević, Jovana and Vasiljević-Radović, Dana and Onjia, Antonije E. and Filipović, Jovanka M. and Tomić, Simonida Lj.",
year = "2015",
abstract = "Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal. (C) 2015 Elsevier B.V. All rights reserved.",
journal = "Applied Surface Science",
title = "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution",
volume = "338",
pages = "178-189",
doi = "10.1016/j.apsusc.2015.02.133"
}

Antić, K. M., Babić, M. M., Vuković Jovasević, J., Vasiljević-Radović, D., Onjia, A. E., Filipović, J. M.,& Tomić, S. Lj.. (2015). Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science, 338, 178-189.
https://doi.org/10.1016/j.apsusc.2015.02.133

Antić KM, Babić MM, Vuković Jovasević J, Vasiljević-Radović D, Onjia AE, Filipović JM, Tomić SL. Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science. 2015;338:178-189.
doi:10.1016/j.apsusc.2015.02.133 .

Antić, Katarina M., Babić, Marija M., Vuković Jovasević, Jovana, Vasiljević-Radović, Dana, Onjia, Antonije E., Filipović, Jovanka M., Tomić, Simonida Lj., "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution" in Applied Surface Science, 338 (2015):178-189,
https://doi.org/10.1016/j.apsusc.2015.02.133 . .

TY  - JOUR
AU  - Jovanović, Željka
AU  - Krklješ, Aleksandra N.
AU  - Stojkovska, Jasmina
AU  - Tomić, Simonida Lj.
AU  - Obradović, Bojana
AU  - Mišković-Stanković, Vesna B.
AU  - Kačarević-Popović, Zorica M.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4471
AB  - This work describes radiolytic synthesis of silver nanoparticles (Ag NPs) within the poly(N-vinyl-2-pyrrolidone) (PVP) hydrogel. The hydrogel matrix was obtained by gamma irradiation-induced cross-linking, while the in situ reduction of Ag(+) ions was performed using strong reducing species formed under water radiolysis. Absorption spectrum of the Ag/PVP nanocomposite confirmed the formation of Ag NPs, showing the surface plasmon band maxima at 405 nm. Ag/PVP nanocomposites were characterized by XRD and TEM analysis, accompanied with investigations of swelling and diffusion properties in the simulated body fluid at 37 degrees C, and mechanical properties in bioreactor conditions. It was shown that Ag/PVP nanocomposite exhibited higher values of equilibrium swelling degree, Youngs modulus, and molar mass between crosslinks, while lower values of the diffusion coefficient and effective crosslink density were obtained, as compared to the pure PVP. (C) 2011 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Synthesis and characterization of silver/poly(N-vinyl-2-pyrrolidone) hydrogel nanocomposite obtained by in situ radiolytic method
VL  - 80
IS  - 11
SP  - 1208
EP  - 1215
DO  - 10.1016/j.radphyschem.2011.06.005
ER  - 

@article{
author = "Jovanović, Željka and Krklješ, Aleksandra N. and Stojkovska, Jasmina and Tomić, Simonida Lj. and Obradović, Bojana and Mišković-Stanković, Vesna B. and Kačarević-Popović, Zorica M.",
year = "2011",
abstract = "This work describes radiolytic synthesis of silver nanoparticles (Ag NPs) within the poly(N-vinyl-2-pyrrolidone) (PVP) hydrogel. The hydrogel matrix was obtained by gamma irradiation-induced cross-linking, while the in situ reduction of Ag(+) ions was performed using strong reducing species formed under water radiolysis. Absorption spectrum of the Ag/PVP nanocomposite confirmed the formation of Ag NPs, showing the surface plasmon band maxima at 405 nm. Ag/PVP nanocomposites were characterized by XRD and TEM analysis, accompanied with investigations of swelling and diffusion properties in the simulated body fluid at 37 degrees C, and mechanical properties in bioreactor conditions. It was shown that Ag/PVP nanocomposite exhibited higher values of equilibrium swelling degree, Youngs modulus, and molar mass between crosslinks, while lower values of the diffusion coefficient and effective crosslink density were obtained, as compared to the pure PVP. (C) 2011 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Synthesis and characterization of silver/poly(N-vinyl-2-pyrrolidone) hydrogel nanocomposite obtained by in situ radiolytic method",
volume = "80",
number = "11",
pages = "1208-1215",
doi = "10.1016/j.radphyschem.2011.06.005"
}

Jovanović, Ž., Krklješ, A. N., Stojkovska, J., Tomić, S. Lj., Obradović, B., Mišković-Stanković, V. B.,& Kačarević-Popović, Z. M.. (2011). Synthesis and characterization of silver/poly(N-vinyl-2-pyrrolidone) hydrogel nanocomposite obtained by in situ radiolytic method. in Radiation Physics and Chemistry, 80(11), 1208-1215.
https://doi.org/10.1016/j.radphyschem.2011.06.005

Jovanović Ž, Krklješ AN, Stojkovska J, Tomić SL, Obradović B, Mišković-Stanković VB, Kačarević-Popović ZM. Synthesis and characterization of silver/poly(N-vinyl-2-pyrrolidone) hydrogel nanocomposite obtained by in situ radiolytic method. in Radiation Physics and Chemistry. 2011;80(11):1208-1215.
doi:10.1016/j.radphyschem.2011.06.005 .

Jovanović, Željka, Krklješ, Aleksandra N., Stojkovska, Jasmina, Tomić, Simonida Lj., Obradović, Bojana, Mišković-Stanković, Vesna B., Kačarević-Popović, Zorica M., "Synthesis and characterization of silver/poly(N-vinyl-2-pyrrolidone) hydrogel nanocomposite obtained by in situ radiolytic method" in Radiation Physics and Chemistry, 80, no. 11 (2011):1208-1215,
https://doi.org/10.1016/j.radphyschem.2011.06.005 . .

TY  - JOUR
AU  - Jovasevic, J. S.
AU  - Dimitrijević, Suzana I.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Suljovrujić, Edin H.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6919
AB  - A simple and fast approach to the design and production of new hybrid polymeric biomaterials with silver particles is presented in this work. Silver/semi-interpenetrating network hybrid hydrogels (Ag/semi-IPNHHs) were prepared through an optimized solution crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), in the presence of PVP, a silver salt and a reducing green agent (Ag/P(HEMA/IA)/PVP). PVP was chosen due to its protective, reduction, and nucleation properties in the production of metal particles. The structure of the Ag/semi-IPNHH was characterized by Fourier transform infrared spectroscopy (FTIR). The presence of silver and PVP in the network was confirmed by FTIR spectra. The results obtained by dynamic mechanical analysis (DMA) showed good mechanical properties for all samples. The swelling studies of Ag/P(HEMA/IA)/PVP were conducted in the temperature range of 25-55 degrees C, in the buffer of pH 7.40. The Ag/semi-IPNHH showed temperature-sensitive swelling properties, with the lower critical solution temperature (LCST) values in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus and C. albicans pathogens. It was concluded that the antimicrobial potential depends on the hydrogels composition and the type of microbes
T2  - Acta Physica Polonica A
T1  - Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels
VL  - 120
IS  - 2
SP  - 279
EP  - 283
DO  - 10.12693/APhysPolA.120.279
ER  - 

@article{
author = "Jovasevic, J. S. and Dimitrijević, Suzana I. and Filipović, Jovanka M. and Tomić, Simonida Lj. and Mićić, Maja M. and Suljovrujić, Edin H.",
year = "2011",
abstract = "A simple and fast approach to the design and production of new hybrid polymeric biomaterials with silver particles is presented in this work. Silver/semi-interpenetrating network hybrid hydrogels (Ag/semi-IPNHHs) were prepared through an optimized solution crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), in the presence of PVP, a silver salt and a reducing green agent (Ag/P(HEMA/IA)/PVP). PVP was chosen due to its protective, reduction, and nucleation properties in the production of metal particles. The structure of the Ag/semi-IPNHH was characterized by Fourier transform infrared spectroscopy (FTIR). The presence of silver and PVP in the network was confirmed by FTIR spectra. The results obtained by dynamic mechanical analysis (DMA) showed good mechanical properties for all samples. The swelling studies of Ag/P(HEMA/IA)/PVP were conducted in the temperature range of 25-55 degrees C, in the buffer of pH 7.40. The Ag/semi-IPNHH showed temperature-sensitive swelling properties, with the lower critical solution temperature (LCST) values in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus and C. albicans pathogens. It was concluded that the antimicrobial potential depends on the hydrogels composition and the type of microbes",
journal = "Acta Physica Polonica A",
title = "Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels",
volume = "120",
number = "2",
pages = "279-283",
doi = "10.12693/APhysPolA.120.279"
}

Jovasevic, J. S., Dimitrijević, S. I., Filipović, J. M., Tomić, S. Lj., Mićić, M. M.,& Suljovrujić, E. H.. (2011). Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels. in Acta Physica Polonica A, 120(2), 279-283.
https://doi.org/10.12693/APhysPolA.120.279

Jovasevic JS, Dimitrijević SI, Filipović JM, Tomić SL, Mićić MM, Suljovrujić EH. Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels. in Acta Physica Polonica A. 2011;120(2):279-283.
doi:10.12693/APhysPolA.120.279 .

Jovasevic, J. S., Dimitrijević, Suzana I., Filipović, Jovanka M., Tomić, Simonida Lj., Mićić, Maja M., Suljovrujić, Edin H., "Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hybrid Hydrogels" in Acta Physica Polonica A, 120, no. 2 (2011):279-283,
https://doi.org/10.12693/APhysPolA.120.279 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Dobić, Sava N.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3961
AB  - pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
VL  - 79
IS  - 5
SP  - 643
EP  - 649
DO  - 10.1016/j.radphyschem.2009.11.015
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Dobić, Sava N. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application",
volume = "79",
number = "5",
pages = "643-649",
doi = "10.1016/j.radphyschem.2009.11.015"
}

Tomić, S. Lj., Mićić, M. M., Dobić, S. N., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry, 79(5), 643-649.
https://doi.org/10.1016/j.radphyschem.2009.11.015

Tomić SL, Mićić MM, Dobić SN, Filipović JM, Suljovrujić EH. Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry. 2010;79(5):643-649.
doi:10.1016/j.radphyschem.2009.11.015 .

Tomić, Simonida Lj., Mićić, Maja M., Dobić, Sava N., Filipović, Jovanka M., Suljovrujić, Edin H., "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application" in Radiation Physics and Chemistry, 79, no. 5 (2010):643-649,
https://doi.org/10.1016/j.radphyschem.2009.11.015 . .

TY  - JOUR
AU  - Jovasevic, Jovana S.
AU  - Mićić, Maja M.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
AU  - Dimitrijević, Suzana I.
AU  - Tomić, Simonida Lj.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4052
AB  - New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag//P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.
T2  - Hemijska industrija
T1  - Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver
VL  - 64
IS  - 3
SP  - 209
EP  - 214
DO  - 10.2298/HEMIND091221030J
ER  - 

@article{
author = "Jovasevic, Jovana S. and Mićić, Maja M. and Suljovrujić, Edin H. and Filipović, Jovanka M. and Dimitrijević, Suzana I. and Tomić, Simonida Lj.",
year = "2010",
abstract = "New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag//P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.",
journal = "Hemijska industrija",
title = "Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver",
volume = "64",
number = "3",
pages = "209-214",
doi = "10.2298/HEMIND091221030J"
}

Jovasevic, J. S., Mićić, M. M., Suljovrujić, E. H., Filipović, J. M., Dimitrijević, S. I.,& Tomić, S. Lj.. (2010). Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver. in Hemijska industrija, 64(3), 209-214.
https://doi.org/10.2298/HEMIND091221030J

Jovasevic JS, Mićić MM, Suljovrujić EH, Filipović JM, Dimitrijević SI, Tomić SL. Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver. in Hemijska industrija. 2010;64(3):209-214.
doi:10.2298/HEMIND091221030J .

Jovasevic, Jovana S., Mićić, Maja M., Suljovrujić, Edin H., Filipović, Jovanka M., Dimitrijević, Suzana I., Tomić, Simonida Lj., "Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver" in Hemijska industrija, 64, no. 3 (2010):209-214,
https://doi.org/10.2298/HEMIND091221030J . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Dokic, D.
AU  - Vasiljević-Radović, D. G.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3907
AB  - Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.
T2  - Materials and Manufacturing Processes
T1  - Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application
VL  - 24
IS  - 10-11
SP  - 1197
EP  - 1201
DO  - 10.1080/10426910903022247
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Dokic, D. and Vasiljević-Radović, D. G. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2009",
abstract = "Silver(I) complexes based on itaconic acid hydrogel were prepared and characterized in order to examine the potential use of these materials. FTIR, AFM, in vitro fluid-uptake, metal sorption, and antibacterial activity assay measurements were used for the characterization. Silver(I) ion uptake by hydrogels based on 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and different content of itaconic acid (2; 3.5; 5mol%) were determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified, and the stability in in-vitro condition was determined. Incorporation of silver(I) ions into hydrogels and the influence of these ions on material diffusion properties were analyzed. It was found that the itaconic acid moiety is the determining factor which influences metal ion binding and, therefore, fluid uptake inside the polymer network. Furthermore, obtained hydrogels showed a satisfactory antibacterial activity.",
journal = "Materials and Manufacturing Processes",
title = "Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application",
volume = "24",
number = "10-11",
pages = "1197-1201",
doi = "10.1080/10426910903022247"
}

Tomić, S. Lj., Mićić, M. M., Dokic, D., Vasiljević-Radović, D. G., Filipović, J. M.,& Suljovrujić, E. H.. (2009). Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application. in Materials and Manufacturing Processes, 24(10-11), 1197-1201.
https://doi.org/10.1080/10426910903022247

Tomić SL, Mićić MM, Dokic D, Vasiljević-Radović DG, Filipović JM, Suljovrujić EH. Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application. in Materials and Manufacturing Processes. 2009;24(10-11):1197-1201.
doi:10.1080/10426910903022247 .

Tomić, Simonida Lj., Mićić, Maja M., Dokic, D., Vasiljević-Radović, D. G., Filipović, Jovanka M., Suljovrujić, Edin H., "Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application" in Materials and Manufacturing Processes, 24, no. 10-11 (2009):1197-1201,
https://doi.org/10.1080/10426910903022247 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Krezović, Bojana D.
AU  - Dobić, Sava N.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3967
AB  - pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
T2  - Hemijska industrija
T1  - Smart Hydrogels Based on Itaconic Acid for Biomedical Application
VL  - 63
IS  - 6
SP  - 603
EP  - 610
DO  - 10.2298/HEMIND0906603T
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Krezović, Bojana D. and Dobić, Sava N. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2009",
abstract = "pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.",
journal = "Hemijska industrija",
title = "Smart Hydrogels Based on Itaconic Acid for Biomedical Application",
volume = "63",
number = "6",
pages = "603-610",
doi = "10.2298/HEMIND0906603T"
}

Tomić, S. Lj., Mićić, M. M., Krezović, B. D., Dobić, S. N., Suljovrujić, E. H.,& Filipović, J. M.. (2009). Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija, 63(6), 603-610.
https://doi.org/10.2298/HEMIND0906603T

Tomić SL, Mićić MM, Krezović BD, Dobić SN, Suljovrujić EH, Filipović JM. Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija. 2009;63(6):603-610.
doi:10.2298/HEMIND0906603T .

Tomić, Simonida Lj., Mićić, Maja M., Krezović, Bojana D., Dobić, Sava N., Suljovrujić, Edin H., Filipović, Jovanka M., "Smart Hydrogels Based on Itaconic Acid for Biomedical Application" in Hemijska industrija, 63, no. 6 (2009):603-610,
https://doi.org/10.2298/HEMIND0906603T . .

TY  - JOUR
AU  - Mićić, Maja M.
AU  - Tomić, Simonida Lj.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6851
AB  - Silver(I) itaconic acid-based hydrogel complexes were synthesized and characterized in order to examine the potential use of these systems; FTIR, AFM, in vitro fluid-uptake, metal sorption and antibacterial activity assay measurements were used for the characterization. Metal (silver(I)) ion uptaken by IA-based hydrogels was determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified and the stability in in vitro condition was determined. Incorporation of silver(l) ions into hydrogels and the influence of these ions on the diffusion properties of hydrogels were analyzed and discussed, too; it was found that the itaconic acid moiety in hydrogels is the determining factor which influences metal ion binding and therefore fluid uptake inside the polymeric network. Furthermore, Silver(I) itaconic acid-based hydrogel showed a satisfactory antibacterial activity. The most advanced feature of these materials is that the silver ions embedded throughout the networks leaches out via controlled manner with time in aqueous media. Therefore, the ions escape from the swollen networks with time and interact with the bacteria. Because of a good dispersion of silver ions in Ag(I)-P(HEMA/2IA) hydrogel complex, we have evaluated the antibacterial activity for this sample. As expected, the number of colonies grown surrounding the Ag(I)-P(HEMA/2IA) hydrogel complex was found to be almost nil, whereas the pare P(HEMA/2IA) hydrogel did not show any effect on Escherichia coli. Therefore, we conclude that the Ag(I)-P(HEMA/IA) hydrogel complexes are excellent antibacterial materials. Due to these facts, the silver ion IA-based hydrogel complexes reported here might be used as smart materials in the range of biomedical applications, including drug-delivery devices, biosensors, wound healing dressings, tissue reconstruction and organ repair.
T2  - Hemijska industrija
T1  - Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel
VL  - 63
IS  - 3
SP  - 137
EP  - 142
DO  - 10.2298/HEMIND0903137M
ER  - 

@article{
author = "Mićić, Maja M. and Tomić, Simonida Lj. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2009",
abstract = "Silver(I) itaconic acid-based hydrogel complexes were synthesized and characterized in order to examine the potential use of these systems; FTIR, AFM, in vitro fluid-uptake, metal sorption and antibacterial activity assay measurements were used for the characterization. Metal (silver(I)) ion uptaken by IA-based hydrogels was determined by inductively coupled plasma mass spectrometry. The coordination sites for metal ions were identified and the stability in in vitro condition was determined. Incorporation of silver(l) ions into hydrogels and the influence of these ions on the diffusion properties of hydrogels were analyzed and discussed, too; it was found that the itaconic acid moiety in hydrogels is the determining factor which influences metal ion binding and therefore fluid uptake inside the polymeric network. Furthermore, Silver(I) itaconic acid-based hydrogel showed a satisfactory antibacterial activity. The most advanced feature of these materials is that the silver ions embedded throughout the networks leaches out via controlled manner with time in aqueous media. Therefore, the ions escape from the swollen networks with time and interact with the bacteria. Because of a good dispersion of silver ions in Ag(I)-P(HEMA/2IA) hydrogel complex, we have evaluated the antibacterial activity for this sample. As expected, the number of colonies grown surrounding the Ag(I)-P(HEMA/2IA) hydrogel complex was found to be almost nil, whereas the pare P(HEMA/2IA) hydrogel did not show any effect on Escherichia coli. Therefore, we conclude that the Ag(I)-P(HEMA/IA) hydrogel complexes are excellent antibacterial materials. Due to these facts, the silver ion IA-based hydrogel complexes reported here might be used as smart materials in the range of biomedical applications, including drug-delivery devices, biosensors, wound healing dressings, tissue reconstruction and organ repair.",
journal = "Hemijska industrija",
title = "Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel",
volume = "63",
number = "3",
pages = "137-142",
doi = "10.2298/HEMIND0903137M"
}

Mićić, M. M., Tomić, S. Lj., Filipović, J. M.,& Suljovrujić, E. H.. (2009). Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel. in Hemijska industrija, 63(3), 137-142.
https://doi.org/10.2298/HEMIND0903137M

Mićić MM, Tomić SL, Filipović JM, Suljovrujić EH. Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel. in Hemijska industrija. 2009;63(3):137-142.
doi:10.2298/HEMIND0903137M .

Mićić, Maja M., Tomić, Simonida Lj., Filipović, Jovanka M., Suljovrujić, Edin H., "Silver(I)-Complexes with An Itaconic Acid-Based Hydrogel" in Hemijska industrija, 63, no. 3 (2009):137-142,
https://doi.org/10.2298/HEMIND0903137M . .

TY  - JOUR
AU  - Kačarević-Popović, Zorica M.
AU  - Tomić, Simonida Lj.
AU  - Krklješ, Aleksandra N.
AU  - Mićić, Maja M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6665
AB  - Ag-poy(BIS-co-HEMA-co-IA) nanocomposites are prepared via in situ reduction of silver salt embedded in swollen polymer gels by employing gamma irradiation. Hydrogels based on 2-hydroxyethyl methacrylate, itaconic acid and four types of poly(alkylene glycol) acrylate or methacrylate (Bisomers) were previously prepared using gamma irradiation. The nanocomposites are characterized by using UV-vis, swelling measurements and thermal analysis. Evolution of plasmon absorption detected by UV-vis spectro photometry indicated generation of Ag nanoparticles in polymer hydrogels. Altering the structure of the hydrogels did not lead to alternation of the position of the absorption maximum. The bulk property of equilibrium swelling is dependent on the presence of the Ag nanostructures. The initial thermal stability of the polymer is slightly increased due to presence of silver as nanofiller. (c) 2007 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Radiolytic synthesis of Ag-poly(BIS-co-HEMA-co-IA) nanocomposites
VL  - 76
IS  - 8-9
SP  - 1333
EP  - 1336
DO  - 10.1016/j.radphyschem.2007.02.026
ER  - 

@article{
author = "Kačarević-Popović, Zorica M. and Tomić, Simonida Lj. and Krklješ, Aleksandra N. and Mićić, Maja M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "Ag-poy(BIS-co-HEMA-co-IA) nanocomposites are prepared via in situ reduction of silver salt embedded in swollen polymer gels by employing gamma irradiation. Hydrogels based on 2-hydroxyethyl methacrylate, itaconic acid and four types of poly(alkylene glycol) acrylate or methacrylate (Bisomers) were previously prepared using gamma irradiation. The nanocomposites are characterized by using UV-vis, swelling measurements and thermal analysis. Evolution of plasmon absorption detected by UV-vis spectro photometry indicated generation of Ag nanoparticles in polymer hydrogels. Altering the structure of the hydrogels did not lead to alternation of the position of the absorption maximum. The bulk property of equilibrium swelling is dependent on the presence of the Ag nanostructures. The initial thermal stability of the polymer is slightly increased due to presence of silver as nanofiller. (c) 2007 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Radiolytic synthesis of Ag-poly(BIS-co-HEMA-co-IA) nanocomposites",
volume = "76",
number = "8-9",
pages = "1333-1336",
doi = "10.1016/j.radphyschem.2007.02.026"
}

Kačarević-Popović, Z. M., Tomić, S. Lj., Krklješ, A. N., Mićić, M. M.,& Suljovrujić, E. H.. (2007). Radiolytic synthesis of Ag-poly(BIS-co-HEMA-co-IA) nanocomposites. in Radiation Physics and Chemistry, 76(8-9), 1333-1336.
https://doi.org/10.1016/j.radphyschem.2007.02.026

Kačarević-Popović ZM, Tomić SL, Krklješ AN, Mićić MM, Suljovrujić EH. Radiolytic synthesis of Ag-poly(BIS-co-HEMA-co-IA) nanocomposites. in Radiation Physics and Chemistry. 2007;76(8-9):1333-1336.
doi:10.1016/j.radphyschem.2007.02.026 .

Kačarević-Popović, Zorica M., Tomić, Simonida Lj., Krklješ, Aleksandra N., Mićić, Maja M., Suljovrujić, Edin H., "Radiolytic synthesis of Ag-poly(BIS-co-HEMA-co-IA) nanocomposites" in Radiation Physics and Chemistry, 76, no. 8-9 (2007):1333-1336,
https://doi.org/10.1016/j.radphyschem.2007.02.026 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3181
AB  - The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the swelling characteristics and the releasing behavior of hydrogels, and the effect of different drugs, theophylline (TPH) and fenethylline hydrochloride (FE), on the releasing behavior of P(HEMA/IA) matrix were investigated in vitro. The diffusion exponents for swelling and drug release indicate that the mechanisms of buffer uptake and drug release are governed by Fickian diffusion. The swelling kinetics and, therefore, the release rate depends on the matrix swelling degree. The drug release was faster for copolymeric hydrogels with a higher content of itaconic acid. Furthermore, the drug release for TPH as model drug was faster due to a smaller molecular size and a weaker interaction of the TPH molecules with(in) the P(HEMA/IA) copolymeric networks. (C) 2006 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation
VL  - 76
IS  - 5
SP  - 801
EP  - 810
DO  - 10.1016/j.radphyschem.2006.05.013
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the swelling characteristics and the releasing behavior of hydrogels, and the effect of different drugs, theophylline (TPH) and fenethylline hydrochloride (FE), on the releasing behavior of P(HEMA/IA) matrix were investigated in vitro. The diffusion exponents for swelling and drug release indicate that the mechanisms of buffer uptake and drug release are governed by Fickian diffusion. The swelling kinetics and, therefore, the release rate depends on the matrix swelling degree. The drug release was faster for copolymeric hydrogels with a higher content of itaconic acid. Furthermore, the drug release for TPH as model drug was faster due to a smaller molecular size and a weaker interaction of the TPH molecules with(in) the P(HEMA/IA) copolymeric networks. (C) 2006 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation",
volume = "76",
number = "5",
pages = "801-810",
doi = "10.1016/j.radphyschem.2006.05.013"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation. in Radiation Physics and Chemistry, 76(5), 801-810.
https://doi.org/10.1016/j.radphyschem.2006.05.013

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation. in Radiation Physics and Chemistry. 2007;76(5):801-810.
doi:10.1016/j.radphyschem.2006.05.013 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation" in Radiation Physics and Chemistry, 76, no. 5 (2007):801-810,
https://doi.org/10.1016/j.radphyschem.2006.05.013 . .

TY  - CONF
AU  - Mićić, Maja M.
AU  - Tomić, Simonida Lj.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6695
AB  - Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.
C3  - Materials Science Forum
T1  - Release and diffusion studies of hydrogels based on itaconic acid
VL  - 555
SP  - 441
EP  - +
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6695
ER  - 

@conference{
author = "Mićić, Maja M. and Tomić, Simonida Lj. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.",
journal = "Materials Science Forum",
title = "Release and diffusion studies of hydrogels based on itaconic acid",
volume = "555",
pages = "441-+",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6695"
}

Mićić, M. M., Tomić, S. Lj., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum, 555, 441-+.
https://hdl.handle.net/21.15107/rcub_vinar_6695

Mićić MM, Tomić SL, Filipović JM, Suljovrujić EH. Release and diffusion studies of hydrogels based on itaconic acid. in Materials Science Forum. 2007;555:441-+.
https://hdl.handle.net/21.15107/rcub_vinar_6695 .

Mićić, Maja M., Tomić, Simonida Lj., Filipović, Jovanka M., Suljovrujić, Edin H., "Release and diffusion studies of hydrogels based on itaconic acid" in Materials Science Forum, 555 (2007):441-+,
https://hdl.handle.net/21.15107/rcub_vinar_6695 .

TY  - JOUR
AU  - Mićić, Maja M.
AU  - Tomić, Simonida Lj.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6742
AB  - New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25 degrees C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37 degrees C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hernolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.
T2  - Hemijska industrija
T1  - Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
VL  - 61
IS  - 2
SP  - 83
EP  - 89
DO  - 10.2298/HEMIND0702083M
ER  - 

@article{
author = "Mićić, Maja M. and Tomić, Simonida Lj. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2007",
abstract = "New types of hydrogels were prepared by the radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid and four different poly(alkylene glycol) (meth)acrylate components (Bisomers) in a water/ethanol mixture as solvent. The polymers swell in water at 25 degrees C to yield homogeneous transparent hydrogels. All the hydrogels displayed pH sensitive behavior in buffers of the pH range from 2.20 to 7.40, under conditions similar to those of biological fluids. The presence of these two comonomers, which were added to HEMA, increased the swelling degree of the hydrogels and gave gels with better elasticity. The hydrogels were thermally stable in the vicinity of the physiological temperature (37 degrees C). The copolymer containing pure poly(ethylene glycol) acrylate units generally had the best properties. The tests performed on the hydrogels confirmed that they were neither hernolytic nor cytotoxic. The copolymer samples showed better cell viability and less hemolytic activity than the PHEMA sample, confirming the assumption that poly(alkylene glycols) improve the biocompatibility of hydrogels. Due to their swelling and mechanical characteristics, as well as the very good biocompatibility and bioadhesive properties, poly(Bisomer/HEMA/IA) hydrogels are promising for utilization in the field of biomedicals, especially for the controlled release of drugs.",
journal = "Hemijska industrija",
title = "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid",
volume = "61",
number = "2",
pages = "83-89",
doi = "10.2298/HEMIND0702083M"
}

Mićić, M. M., Tomić, S. Lj., Filipović, J. M.,& Suljovrujić, E. H.. (2007). Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Hemijska industrija, 61(2), 83-89.
https://doi.org/10.2298/HEMIND0702083M

Mićić MM, Tomić SL, Filipović JM, Suljovrujić EH. Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Hemijska industrija. 2007;61(2):83-89.
doi:10.2298/HEMIND0702083M .

Mićić, Maja M., Tomić, Simonida Lj., Filipović, Jovanka M., Suljovrujić, Edin H., "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid" in Hemijska industrija, 61, no. 2 (2007):83-89,
https://doi.org/10.2298/HEMIND0702083M . .

TY  - JOUR
AU  - Suljovrujić, Edin H.
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
AU  - Mitrić, Miodrag
AU  - Mitrovic, M.
AU  - Tomić, Simonida Lj.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2570
AB  - The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly L-lactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable. (C) 2006 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial
VL  - 76
IS  - 4
SP  - 722
EP  - 728
DO  - 10.1016/j.radphyschem.2006.02.013
ER  - 

@article{
author = "Suljovrujić, Edin H. and Ignjatović, Nenad L. and Uskoković, Dragan and Mitrić, Miodrag and Mitrovic, M. and Tomić, Simonida Lj.",
year = "2007",
abstract = "The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly L-lactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable. (C) 2006 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial",
volume = "76",
number = "4",
pages = "722-728",
doi = "10.1016/j.radphyschem.2006.02.013"
}

Suljovrujić, E. H., Ignjatović, N. L., Uskoković, D., Mitrić, M., Mitrovic, M.,& Tomić, S. Lj.. (2007). Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial. in Radiation Physics and Chemistry, 76(4), 722-728.
https://doi.org/10.1016/j.radphyschem.2006.02.013

Suljovrujić EH, Ignjatović NL, Uskoković D, Mitrić M, Mitrovic M, Tomić SL. Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial. in Radiation Physics and Chemistry. 2007;76(4):722-728.
doi:10.1016/j.radphyschem.2006.02.013 .

Suljovrujić, Edin H., Ignjatović, Nenad L., Uskoković, Dragan, Mitrić, Miodrag, Mitrovic, M., Tomić, Simonida Lj., "Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial" in Radiation Physics and Chemistry, 76, no. 4 (2007):722-728,
https://doi.org/10.1016/j.radphyschem.2006.02.013 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3073
AB  - Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.
T2  - Polymer Bulletin
T1  - Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
VL  - 57
IS  - 5
SP  - 691
EP  - 702
DO  - 10.1007/s00289-006-0606-3
ER  - 

@article{
author = "Tomić, Simonida Lj. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2006",
abstract = "Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.",
journal = "Polymer Bulletin",
title = "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid",
volume = "57",
number = "5",
pages = "691-702",
doi = "10.1007/s00289-006-0606-3"
}

Tomić, S. Lj., Suljovrujić, E. H.,& Filipović, J. M.. (2006). Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin, 57(5), 691-702.
https://doi.org/10.1007/s00289-006-0606-3

Tomić SL, Suljovrujić EH, Filipović JM. Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin. 2006;57(5):691-702.
doi:10.1007/s00289-006-0606-3 .

Tomić, Simonida Lj., Suljovrujić, Edin H., Filipović, Jovanka M., "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid" in Polymer Bulletin, 57, no. 5 (2006):691-702,
https://doi.org/10.1007/s00289-006-0606-3 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6527
AB  - Hydrogels based on 2-hydroxyethyl methacrylate and different types of poly(alkylene glycol) acrylates and methacrylates, with a small percent of itaconic acid, have been prepared by solution copolymerization using gamma irradiation. In this study, the swelling behavior and network parameters of these hydrogels as a function of poly(alkylene glycol) acrylate type are reported for the first time. Morphology of the obtained hydrogels was characterized using scanning electron microscopy (SEM) technique.
T2  - Materials Science Forum
T1  - Hydrogels based on 2-hydroxyethyl methacrylate obtained by gamma irradiation
VL  - 494
SP  - 199
EP  - 203
DO  - 10.4028/www.scientific.net/MSF.494.199
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2005",
abstract = "Hydrogels based on 2-hydroxyethyl methacrylate and different types of poly(alkylene glycol) acrylates and methacrylates, with a small percent of itaconic acid, have been prepared by solution copolymerization using gamma irradiation. In this study, the swelling behavior and network parameters of these hydrogels as a function of poly(alkylene glycol) acrylate type are reported for the first time. Morphology of the obtained hydrogels was characterized using scanning electron microscopy (SEM) technique.",
journal = "Materials Science Forum",
title = "Hydrogels based on 2-hydroxyethyl methacrylate obtained by gamma irradiation",
volume = "494",
pages = "199-203",
doi = "10.4028/www.scientific.net/MSF.494.199"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2005). Hydrogels based on 2-hydroxyethyl methacrylate obtained by gamma irradiation. in Materials Science Forum, 494, 199-203.
https://doi.org/10.4028/www.scientific.net/MSF.494.199

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Hydrogels based on 2-hydroxyethyl methacrylate obtained by gamma irradiation. in Materials Science Forum. 2005;494:199-203.
doi:10.4028/www.scientific.net/MSF.494.199 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Hydrogels based on 2-hydroxyethyl methacrylate obtained by gamma irradiation" in Materials Science Forum, 494 (2005):199-203,
https://doi.org/10.4028/www.scientific.net/MSF.494.199 . .