TY  - CONF
AU  - Đorđević, Neda O.
AU  - Keta, Otilija D.
AU  - Petković, Vladana
AU  - Todorović Vukotić, Nevena
AU  - Stanković, Dalibor
AU  - Tešević, V.
AU  - Pajović, Snežana B.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12594
AB  - This study aimed to determine the phenolic compound content, in vitro antioxidative potential, and cytotoxic effects of four red wine samples: a commercial (V) and three clonal wines (V1, V2, and V3). LC/MS-MS, cyclic voltammetry, and MTT assay techniques were employed for this purpose. Results revealed that all wines were rich in phenolic compounds. Clonal wines outperformed the commercial ones in most phenolic compounds (except myricetin). Notably, V2 and V3 showed the highest levels of gallic acid, catechin, and epicatechin. Among them, V3 exhibited superior antioxidative activity. The MTT assay demonstrated stronger cytotoxic effects of the wine samples on pancreas (Bx-PC3) and colon (HT29) carcinoma cells (47% to 16% and 27% to 7% compared to control, respectively) than on the normal lung fibroblasts (MRC-5) cell line (106% to 77%). It can be concluded that HT29 cells were more sensitive than Bx-PC3 cells. Finally, both clonal and commercial wines serve as valuable sources of polyphenolic compounds, which could have a significant role in preventing cancer and diseases related to oxidative stress.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - In vitro biological effects of clonal red wines
SP  - 180
EP  - 183
DO  - 10.46793/ICCBI23.180DJ
ER  - 

@conference{
author = "Đorđević, Neda O. and Keta, Otilija D. and Petković, Vladana and Todorović Vukotić, Nevena and Stanković, Dalibor and Tešević, V. and Pajović, Snežana B.",
year = "2023",
abstract = "This study aimed to determine the phenolic compound content, in vitro antioxidative potential, and cytotoxic effects of four red wine samples: a commercial (V) and three clonal wines (V1, V2, and V3). LC/MS-MS, cyclic voltammetry, and MTT assay techniques were employed for this purpose. Results revealed that all wines were rich in phenolic compounds. Clonal wines outperformed the commercial ones in most phenolic compounds (except myricetin). Notably, V2 and V3 showed the highest levels of gallic acid, catechin, and epicatechin. Among them, V3 exhibited superior antioxidative activity. The MTT assay demonstrated stronger cytotoxic effects of the wine samples on pancreas (Bx-PC3) and colon (HT29) carcinoma cells (47% to 16% and 27% to 7% compared to control, respectively) than on the normal lung fibroblasts (MRC-5) cell line (106% to 77%). It can be concluded that HT29 cells were more sensitive than Bx-PC3 cells. Finally, both clonal and commercial wines serve as valuable sources of polyphenolic compounds, which could have a significant role in preventing cancer and diseases related to oxidative stress.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "In vitro biological effects of clonal red wines",
pages = "180-183",
doi = "10.46793/ICCBI23.180DJ"
}

Đorđević, N. O., Keta, O. D., Petković, V., Todorović Vukotić, N., Stanković, D., Tešević, V.,& Pajović, S. B.. (2023). In vitro biological effects of clonal red wines. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 180-183.
https://doi.org/10.46793/ICCBI23.180DJ

Đorđević NO, Keta OD, Petković V, Todorović Vukotić N, Stanković D, Tešević V, Pajović SB. In vitro biological effects of clonal red wines. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:180-183.
doi:10.46793/ICCBI23.180DJ .

Đorđević, Neda O., Keta, Otilija D., Petković, Vladana, Todorović Vukotić, Nevena, Stanković, Dalibor, Tešević, V., Pajović, Snežana B., "In vitro biological effects of clonal red wines" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):180-183,
https://doi.org/10.46793/ICCBI23.180DJ . .

TY  - CONF
AU  - Keta, Otilija D.
AU  - Petković, Vladana
AU  - Đorđević, Neda O.
AU  - Đorđević, Miloš
AU  - Ivković, Branka
AU  - Dobričić, Vladimir
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12088
AB  - Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays
SP  - 471
EP  - 474
DO  - 10.46793/ICCBI23.471K
ER  - 

@conference{
author = "Keta, Otilija D. and Petković, Vladana and Đorđević, Neda O. and Đorđević, Miloš and Ivković, Branka and Dobričić, Vladimir",
year = "2023",
abstract = "Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays",
pages = "471-474",
doi = "10.46793/ICCBI23.471K"
}

Keta, O. D., Petković, V., Đorđević, N. O., Đorđević, M., Ivković, B.,& Dobričić, V.. (2023). The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 471-474.
https://doi.org/10.46793/ICCBI23.471K

Keta OD, Petković V, Đorđević NO, Đorđević M, Ivković B, Dobričić V. The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:471-474.
doi:10.46793/ICCBI23.471K .

Keta, Otilija D., Petković, Vladana, Đorđević, Neda O., Đorđević, Miloš, Ivković, Branka, Dobričić, Vladimir, "The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):471-474,
https://doi.org/10.46793/ICCBI23.471K . .

TY  - CONF
AU  - Keta, Otilija D.
AU  - Bošković, Jelena
AU  - Petković, Vladana
AU  - Đorđević, Neda O.
AU  - Dobričić, Vladimir
AU  - Čudina, Olivera
AU  - Pajović, Snežana B.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12089
AB  - Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, indicating the promising inhibitory potential of the IBU-Ac compound in both types of cancer cells. This finding is positioned to stimulate further investigation into the potential application of IBU-Ac against these particular types of cancers, while also advocating its use in combination with standard anti-cancer protocols, i.e., chemoterapeutics or radiation therapy. The results of this work are also advocating the development and refinement of dual COX-2 and 5-LOX inhibitors, thus improving their efficacy and safety.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines
SP  - 503
EP  - 506
DO  - 10.46793/ICCBI23.503K
ER  - 

@conference{
author = "Keta, Otilija D. and Bošković, Jelena and Petković, Vladana and Đorđević, Neda O. and Dobričić, Vladimir and Čudina, Olivera and Pajović, Snežana B.",
year = "2023",
abstract = "Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, indicating the promising inhibitory potential of the IBU-Ac compound in both types of cancer cells. This finding is positioned to stimulate further investigation into the potential application of IBU-Ac against these particular types of cancers, while also advocating its use in combination with standard anti-cancer protocols, i.e., chemoterapeutics or radiation therapy. The results of this work are also advocating the development and refinement of dual COX-2 and 5-LOX inhibitors, thus improving their efficacy and safety.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines",
pages = "503-506",
doi = "10.46793/ICCBI23.503K"
}

Keta, O. D., Bošković, J., Petković, V., Đorđević, N. O., Dobričić, V., Čudina, O.,& Pajović, S. B.. (2023). Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 503-506.
https://doi.org/10.46793/ICCBI23.503K

Keta OD, Bošković J, Petković V, Đorđević NO, Dobričić V, Čudina O, Pajović SB. Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:503-506.
doi:10.46793/ICCBI23.503K .

Keta, Otilija D., Bošković, Jelena, Petković, Vladana, Đorđević, Neda O., Dobričić, Vladimir, Čudina, Olivera, Pajović, Snežana B., "Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):503-506,
https://doi.org/10.46793/ICCBI23.503K . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Stanisavljević, Nemanja
AU  - Todorović Vukotić, Nevena
AU  - Novović, Katarina
AU  - Žakula, Jelena
AU  - Stanković, Dalibor M.
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10353
AB  - The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.
T2  - Natural Product Research
T1  - Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix
SP  - 1
EP  - 6
DO  - 10.1080/14786419.2022.2095380
ER  - 

@article{
author = "Đorđević, Neda O. and Stanisavljević, Nemanja and Todorović Vukotić, Nevena and Novović, Katarina and Žakula, Jelena and Stanković, Dalibor M. and Pajović, Snežana B.",
year = "2022",
abstract = "The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.",
journal = "Natural Product Research",
title = "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix",
pages = "1-6",
doi = "10.1080/14786419.2022.2095380"
}

Đorđević, N. O., Stanisavljević, N., Todorović Vukotić, N., Novović, K., Žakula, J., Stanković, D. M.,& Pajović, S. B.. (2022). Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research, 1-6.
https://doi.org/10.1080/14786419.2022.2095380

Đorđević NO, Stanisavljević N, Todorović Vukotić N, Novović K, Žakula J, Stanković DM, Pajović SB. Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research. 2022;:1-6.
doi:10.1080/14786419.2022.2095380 .

Đorđević, Neda O., Stanisavljević, Nemanja, Todorović Vukotić, Nevena, Novović, Katarina, Žakula, Jelena, Stanković, Dalibor M., Pajović, Snežana B., "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix" in Natural Product Research (2022):1-6,
https://doi.org/10.1080/14786419.2022.2095380 . .

TY  - CONF
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Pejić, Snežana
AU  - Pajović, Snežana B.
AU  - Tešević, V.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12586
AB  - Positive effects of moderate wine consumption in individuals with cardiovascular disease, hypertension, diabetes, and cancers have been shown in numerous epidemiological and clinical studies. This research examined the phenolic content of commercial and two clonal Merlot wines as well as their biological potential. The obtained results indicated that all analyzed samples were a good source of phenolic compounds. Cytotoxicity assay on melanoma (A375) and cervical (HeLa) cancer cell lines have shown that all analyzed wines inhibited the growth of human cancer cells in vitro with differing susceptibility among tested cell lines. Clonal wines in the volume ratio of 10 and 20% showed to be more efficient anti-proliferative agents than commercial wine regarding the A375 cells. This could be connected with higher total phenolic content in clonal wines. The effect of all analyzed samples on the A375 cells was greater compared to HeLa cell line.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts
T1  - Phenolic Composition and Cytotoxic Activity of Red Wine
SP  - 153
EP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12586
ER  - 

@conference{
author = "Đorđević, Neda and Todorović Vukotić, Nevena and Korićanac, Lela and Žakula, Jelena and Pejić, Snežana and Pajović, Snežana B. and Tešević, V.",
year = "2022",
abstract = "Positive effects of moderate wine consumption in individuals with cardiovascular disease, hypertension, diabetes, and cancers have been shown in numerous epidemiological and clinical studies. This research examined the phenolic content of commercial and two clonal Merlot wines as well as their biological potential. The obtained results indicated that all analyzed samples were a good source of phenolic compounds. Cytotoxicity assay on melanoma (A375) and cervical (HeLa) cancer cell lines have shown that all analyzed wines inhibited the growth of human cancer cells in vitro with differing susceptibility among tested cell lines. Clonal wines in the volume ratio of 10 and 20% showed to be more efficient anti-proliferative agents than commercial wine regarding the A375 cells. This could be connected with higher total phenolic content in clonal wines. The effect of all analyzed samples on the A375 cells was greater compared to HeLa cell line.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts",
title = "Phenolic Composition and Cytotoxic Activity of Red Wine",
pages = "153-153",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12586"
}

Đorđević, N., Todorović Vukotić, N., Korićanac, L., Žakula, J., Pejić, S., Pajović, S. B.,& Tešević, V.. (2022). Phenolic Composition and Cytotoxic Activity of Red Wine. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts
Belgrade : Society of Physical Chemists of Serbia., 153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12586

Đorđević N, Todorović Vukotić N, Korićanac L, Žakula J, Pejić S, Pajović SB, Tešević V. Phenolic Composition and Cytotoxic Activity of Red Wine. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts. 2022;:153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12586 .

Đorđević, Neda, Todorović Vukotić, Nevena, Korićanac, Lela, Žakula, Jelena, Pejić, Snežana, Pajović, Snežana B., Tešević, V., "Phenolic Composition and Cytotoxic Activity of Red Wine" in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts (2022):153-153,
https://hdl.handle.net/21.15107/rcub_vinar_12586 .

TY  - CONF
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Pejić, Snežana
AU  - Tešević, V.
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12592
AB  - Benefitni efekat crvenog vina na zdravlje ljudi od davnina je poznat. Među alkoholnim pićima crveno vino pokazuje najjači efekat protiv pojave oboljenja povezanih sa oksidativnim stresom, kao što su kardiovaskularna, neurodegenerativna oboljenja, dijabetes i kancer.1 U okviru ove studije ispitan je citotoksični efekat crvenog vina sorte merlo (komercijalno dostupno vino i vina dobijena od klonova VCR1 i VCR101) poreklom iz Crne Gore, berba 2011, u odnosu na ćelijsku liniju kancera pankreasa (PANC-1) i ćelijsku liniju melanoma (A375). Citotoksični efekat vina je određen SRB metodom kroz praćenje ćelijskog preživljavanja kancerskih ćelija 48 sati nakon tretmana sa tri različita zapreminska procenta analiziranih vina (5, 10 i 20%). Dobijeni rezultati su pokazali citotoksični efekat svih analiziranih vina na obe ćelijske linije. Ćelijsko preživljavanje nakon tretmana vinima se kretalo od 36 do 64%. Citotoksični efekat svih vina u odnosu na A375 ćelije je bio veći nego na PANC-1 ćelijsku liniju, što je od posebnog značaja ako se uzme u obzir rezistentnost melanomskih ćelija na postojeće terapeutske tretmane. Takođe, klonska sortna vina su pokazala veći citotoksični efekat na A375 ćelijsku liniju od komercijalno dostupnog vina. Dobijeni rezultati su ukazali da umereno konzumiranje crvenog vina sorte merlo sa specifičnim geografskim poreklom predstavlja dobar izvor bioaktivnih komponenata sa pozitivnim biološkim efektom, što je od posebne važnosti za klonska sortna vina.
PB  - Beograd : Srpsko biološko društvo
C3  - 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka
T1  - Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima
SP  - 321
EP  - 321
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12592
ER  - 

@conference{
author = "Đorđević, Neda and Todorović Vukotić, Nevena and Korićanac, Lela and Žakula, Jelena and Pejić, Snežana and Tešević, V. and Pajović, Snežana B.",
year = "2022",
abstract = "Benefitni efekat crvenog vina na zdravlje ljudi od davnina je poznat. Među alkoholnim pićima crveno vino pokazuje najjači efekat protiv pojave oboljenja povezanih sa oksidativnim stresom, kao što su kardiovaskularna, neurodegenerativna oboljenja, dijabetes i kancer.1 U okviru ove studije ispitan je citotoksični efekat crvenog vina sorte merlo (komercijalno dostupno vino i vina dobijena od klonova VCR1 i VCR101) poreklom iz Crne Gore, berba 2011, u odnosu na ćelijsku liniju kancera pankreasa (PANC-1) i ćelijsku liniju melanoma (A375). Citotoksični efekat vina je određen SRB metodom kroz praćenje ćelijskog preživljavanja kancerskih ćelija 48 sati nakon tretmana sa tri različita zapreminska procenta analiziranih vina (5, 10 i 20%). Dobijeni rezultati su pokazali citotoksični efekat svih analiziranih vina na obe ćelijske linije. Ćelijsko preživljavanje nakon tretmana vinima se kretalo od 36 do 64%. Citotoksični efekat svih vina u odnosu na A375 ćelije je bio veći nego na PANC-1 ćelijsku liniju, što je od posebnog značaja ako se uzme u obzir rezistentnost melanomskih ćelija na postojeće terapeutske tretmane. Takođe, klonska sortna vina su pokazala veći citotoksični efekat na A375 ćelijsku liniju od komercijalno dostupnog vina. Dobijeni rezultati su ukazali da umereno konzumiranje crvenog vina sorte merlo sa specifičnim geografskim poreklom predstavlja dobar izvor bioaktivnih komponenata sa pozitivnim biološkim efektom, što je od posebne važnosti za klonska sortna vina.",
publisher = "Beograd : Srpsko biološko društvo",
journal = "3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka",
title = "Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima",
pages = "321-321",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12592"
}

Đorđević, N., Todorović Vukotić, N., Korićanac, L., Žakula, J., Pejić, S., Tešević, V.,& Pajović, S. B.. (2022). Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima. in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka
Beograd : Srpsko biološko društvo., 321-321.
https://hdl.handle.net/21.15107/rcub_vinar_12592

Đorđević N, Todorović Vukotić N, Korićanac L, Žakula J, Pejić S, Tešević V, Pajović SB. Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima. in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka. 2022;:321-321.
https://hdl.handle.net/21.15107/rcub_vinar_12592 .

Đorđević, Neda, Todorović Vukotić, Nevena, Korićanac, Lela, Žakula, Jelena, Pejić, Snežana, Tešević, V., Pajović, Snežana B., "Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima" in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka (2022):321-321,
https://hdl.handle.net/21.15107/rcub_vinar_12592 .

TY  - CHAP
AU  - Đorđević, Neda O.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12588
AB  - Ova tema je fokusirana na hemijsku i biološku karakterizaciju odabranih uzoraka crvenih vina. Akcenatje stavljen na hemijsku karakterizaciju klonskih sortnih vina vranac i merlo, kao i na procenu antioksidativneaktivnosti merlo vina u ćelijama kvasca. U radu su primenjene brojne analitičke tehnike zaodređivanje koncentracije fenolnih jedinjenja, elementalnog sastava i in vitro antioksidativnu aktivnostiispitivanih uzoraka (spektrofotometrija, ciklična voltametrija, klasična polarografija, EPR spektroskopija,LC-MS/MS, ICP-OES i ICP-MS). Pored antioksidativne, ispitane su i citotoksična i antibakterijska aktivnost odgovarajućihuzoraka vina. Eksperiment na bazi vinskog kvasca je obuhvatio određivanje ukupnih –SHgrupa, kao i enzimskih aktivnosti glutation peroksidaze, glutation reduktaze i katalaze. Eksperimentalnodobijeni podaci za klonska sortna vina merlo ukazuju na poseban doprinos glutation peroksidaze preživljavanjućelija kvasca u uslovima oksidativnog stresa. Konačno, primenom veštačke neuronske mreže razvijenaje brza i precizna metoda za predviđanje uticaja malih promena u vinskom fenolnom profilu naaktivnosti istaknutih enzima antioksidativne zaštite.
AB  - This topic focuses on the chemical and biological characterization of selected red wine samples. Emphasisis placed on the chemical characterisation of clonal wines of Vranac and Merlot varieties, as well ason the evaluation of the antioxidant activity of Merlot wines in yeast cells. Numerous analytical techniqueswere used to determine the concentration of phenolic compounds, elemental composition and invitro antioxidant activity of the tested samples (spectrophotometry, cyclic voltammetry, classical polarography,EPR spectroscopy, LC-MS/MS, ICP-OES and ICP-MS). In addition, total antioxidant activity, cytotoxicand antibacterial activity of the respective wine samples were determined. The wine yeast experimentinvolved determining the total groups –SH, as well as enzymatic activities of glutathione peroxidase, glutathionereductase and catalase. The experimentally obtained data for clonal Merlot wine varieties indicatea particular contribution of glutathione peroxidase to the survival of yeast cells under oxidative stress conditions.Finally, using an artificial neural network (ANN), a rapid and accurate method was developed to predictthe effect of small changes in the wine phenolic profile on the activities of prominent antioxidantenzymes.
PB  - Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo
T2  - Trendovi u molekularnoj biologiji
T1  - Hemijski profil i antioksidativna aktivnost crvenih vina klonova autohtone i internacionalnih sorti vinove loze
T1  - Chemical profile and antioxidative activity of red wines obtained from autochthonous and international grape clone varieties
IS  - 2
SP  - 206
EP  - 222
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12588
ER  - 

@inbook{
author = "Đorđević, Neda O.",
year = "2022",
abstract = "Ova tema je fokusirana na hemijsku i biološku karakterizaciju odabranih uzoraka crvenih vina. Akcenatje stavljen na hemijsku karakterizaciju klonskih sortnih vina vranac i merlo, kao i na procenu antioksidativneaktivnosti merlo vina u ćelijama kvasca. U radu su primenjene brojne analitičke tehnike zaodređivanje koncentracije fenolnih jedinjenja, elementalnog sastava i in vitro antioksidativnu aktivnostiispitivanih uzoraka (spektrofotometrija, ciklična voltametrija, klasična polarografija, EPR spektroskopija,LC-MS/MS, ICP-OES i ICP-MS). Pored antioksidativne, ispitane su i citotoksična i antibakterijska aktivnost odgovarajućihuzoraka vina. Eksperiment na bazi vinskog kvasca je obuhvatio određivanje ukupnih –SHgrupa, kao i enzimskih aktivnosti glutation peroksidaze, glutation reduktaze i katalaze. Eksperimentalnodobijeni podaci za klonska sortna vina merlo ukazuju na poseban doprinos glutation peroksidaze preživljavanjućelija kvasca u uslovima oksidativnog stresa. Konačno, primenom veštačke neuronske mreže razvijenaje brza i precizna metoda za predviđanje uticaja malih promena u vinskom fenolnom profilu naaktivnosti istaknutih enzima antioksidativne zaštite., This topic focuses on the chemical and biological characterization of selected red wine samples. Emphasisis placed on the chemical characterisation of clonal wines of Vranac and Merlot varieties, as well ason the evaluation of the antioxidant activity of Merlot wines in yeast cells. Numerous analytical techniqueswere used to determine the concentration of phenolic compounds, elemental composition and invitro antioxidant activity of the tested samples (spectrophotometry, cyclic voltammetry, classical polarography,EPR spectroscopy, LC-MS/MS, ICP-OES and ICP-MS). In addition, total antioxidant activity, cytotoxicand antibacterial activity of the respective wine samples were determined. The wine yeast experimentinvolved determining the total groups –SH, as well as enzymatic activities of glutathione peroxidase, glutathionereductase and catalase. The experimentally obtained data for clonal Merlot wine varieties indicatea particular contribution of glutathione peroxidase to the survival of yeast cells under oxidative stress conditions.Finally, using an artificial neural network (ANN), a rapid and accurate method was developed to predictthe effect of small changes in the wine phenolic profile on the activities of prominent antioxidantenzymes.",
publisher = "Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo",
journal = "Trendovi u molekularnoj biologiji",
booktitle = "Hemijski profil i antioksidativna aktivnost crvenih vina klonova autohtone i internacionalnih sorti vinove loze, Chemical profile and antioxidative activity of red wines obtained from autochthonous and international grape clone varieties",
number = "2",
pages = "206-222",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12588"
}

Đorđević, N. O.. (2022). Hemijski profil i antioksidativna aktivnost crvenih vina klonova autohtone i internacionalnih sorti vinove loze. in Trendovi u molekularnoj biologiji
Beograd : Institut za molekularnu genetiku i genetičko inženjerstvo.(2), 206-222.
https://hdl.handle.net/21.15107/rcub_vinar_12588

Đorđević NO. Hemijski profil i antioksidativna aktivnost crvenih vina klonova autohtone i internacionalnih sorti vinove loze. in Trendovi u molekularnoj biologiji. 2022;(2):206-222.
https://hdl.handle.net/21.15107/rcub_vinar_12588 .

Đorđević, Neda O., "Hemijski profil i antioksidativna aktivnost crvenih vina klonova autohtone i internacionalnih sorti vinove loze" in Trendovi u molekularnoj biologiji, no. 2 (2022):206-222,
https://hdl.handle.net/21.15107/rcub_vinar_12588 .

TY  - CONF
AU  - Đorđević, Neda
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Todorović Vukotić, Nevena
AU  - Pejić, Snežana
AU  - Tešević, V.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12583
AB  - Melanoma is responsible for 75% of all deaths from skin cancer. Its lethality arises from its rapid progression, easy metastasis and drug-resistance as well. Red wine is a natural product rich in polyphenolic compounds with potent anticancer activities. It seems that in cancer cells these compounds behave as prooxidants initiating reactive oxygen species mediated cellular DNA breakage and consequent cell death. The aim of this study was to investigate prooxidative activity of red wine samples (Merlot variety, commercial as well as VCR1 and VCR101 clonal wines) in melanoma A375 cells, through measuring the relationship of reduced and oxidized form of glutathione (GSH/GSSG) and comparison with the GSH/GSSG ratio in control (untreated melanoma cells). The data obtained showed that tested red wine samples decrease GSH/GSSG ratio in A375 cells compared to control (4.6 ± 0), with the largest decrease noticed in treatment with VCR101 wine (0.66 ± 0.05).
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24
T1  - Examination of Prooxidative Activity of Red Wine in Melanoma Cells
SP  - 699
EP  - 702
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12583
ER  - 

@conference{
author = "Đorđević, Neda and Korićanac, Lela and Žakula, Jelena and Todorović Vukotić, Nevena and Pejić, Snežana and Tešević, V. and Pajović, Snežana B.",
year = "2021",
abstract = "Melanoma is responsible for 75% of all deaths from skin cancer. Its lethality arises from its rapid progression, easy metastasis and drug-resistance as well. Red wine is a natural product rich in polyphenolic compounds with potent anticancer activities. It seems that in cancer cells these compounds behave as prooxidants initiating reactive oxygen species mediated cellular DNA breakage and consequent cell death. The aim of this study was to investigate prooxidative activity of red wine samples (Merlot variety, commercial as well as VCR1 and VCR101 clonal wines) in melanoma A375 cells, through measuring the relationship of reduced and oxidized form of glutathione (GSH/GSSG) and comparison with the GSH/GSSG ratio in control (untreated melanoma cells). The data obtained showed that tested red wine samples decrease GSH/GSSG ratio in A375 cells compared to control (4.6 ± 0), with the largest decrease noticed in treatment with VCR101 wine (0.66 ± 0.05).",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24",
title = "Examination of Prooxidative Activity of Red Wine in Melanoma Cells",
pages = "699-702",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12583"
}

Đorđević, N., Korićanac, L., Žakula, J., Todorović Vukotić, N., Pejić, S., Tešević, V.,& Pajović, S. B.. (2021). Examination of Prooxidative Activity of Red Wine in Melanoma Cells. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24
The Society of Physical Chemists of Serbia., 699-702.
https://hdl.handle.net/21.15107/rcub_vinar_12583

Đorđević N, Korićanac L, Žakula J, Todorović Vukotić N, Pejić S, Tešević V, Pajović SB. Examination of Prooxidative Activity of Red Wine in Melanoma Cells. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24. 2021;:699-702.
https://hdl.handle.net/21.15107/rcub_vinar_12583 .

Đorđević, Neda, Korićanac, Lela, Žakula, Jelena, Todorović Vukotić, Nevena, Pejić, Snežana, Tešević, V., Pajović, Snežana B., "Examination of Prooxidative Activity of Red Wine in Melanoma Cells" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24 (2021):699-702,
https://hdl.handle.net/21.15107/rcub_vinar_12583 .

TY  - CONF
AU  - Todorović, Ana
AU  - Drakulić, Dunja
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Miletić, J.
AU  - Pejić, Snežana
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12580
AB  - The literature emphasizes the involvement of oxidative stress in the etiopathogenesis of many uterine diseases. Antioxidant system (AOS) represents the protective mechanism used by cells to neutralize overproduced reactive oxygen species (ROS) and prevent oxidative stress. We have previously shown that in gynecological patients with various diagnoses, the reproductive and other factors may be associated with antioxidant capacity and the ability to defend against oxidative damage. In this study, we examined the changes in expression of antioxidant enzymes (AOE): superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the blood of women with endometrial hyperplasia. Our results indicate that hyperplasia induces perturbance in oxidative balance, particularly in glutathione redox cycle enzymes.
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
T1  - Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia
SP  - 308
EP  - 311
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12580
ER  - 

@conference{
author = "Todorović, Ana and Drakulić, Dunja and Gavrilović, Ljubica and Stojiljković, Vesna and Popović, Nataša M. and Đorđević, Neda and Todorović Vukotić, Nevena and Miletić, J. and Pejić, Snežana and Pajović, Snežana B.",
year = "2021",
abstract = "The literature emphasizes the involvement of oxidative stress in the etiopathogenesis of many uterine diseases. Antioxidant system (AOS) represents the protective mechanism used by cells to neutralize overproduced reactive oxygen species (ROS) and prevent oxidative stress. We have previously shown that in gynecological patients with various diagnoses, the reproductive and other factors may be associated with antioxidant capacity and the ability to defend against oxidative damage. In this study, we examined the changes in expression of antioxidant enzymes (AOE): superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the blood of women with endometrial hyperplasia. Our results indicate that hyperplasia induces perturbance in oxidative balance, particularly in glutathione redox cycle enzymes.",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24",
title = "Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia",
pages = "308-311",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12580"
}

Todorović, A., Drakulić, D., Gavrilović, L., Stojiljković, V., Popović, N. M., Đorđević, N., Todorović Vukotić, N., Miletić, J., Pejić, S.,& Pajović, S. B.. (2021). Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
The Society of Physical Chemists of Serbia., 308-311.
https://hdl.handle.net/21.15107/rcub_vinar_12580

Todorović A, Drakulić D, Gavrilović L, Stojiljković V, Popović NM, Đorđević N, Todorović Vukotić N, Miletić J, Pejić S, Pajović SB. Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24. 2021;:308-311.
https://hdl.handle.net/21.15107/rcub_vinar_12580 .

Todorović, Ana, Drakulić, Dunja, Gavrilović, Ljubica, Stojiljković, Vesna, Popović, Nataša M., Đorđević, Neda, Todorović Vukotić, Nevena, Miletić, J., Pejić, Snežana, Pajović, Snežana B., "Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24 (2021):308-311,
https://hdl.handle.net/21.15107/rcub_vinar_12580 .

TY  - JOUR
AU  - Todorović Vukotić, Nevena
AU  - Đorđević, Jelena
AU  - Pejić, Snežana
AU  - Đorđević, Neda O.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9078
AB  - Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
T2  - Archives of Toxicology
T1  - Antidepressants- and antipsychotics-induced hepatotoxicity
VL  - 95
IS  - 3
SP  - 767
EP  - 789
DO  - 10.1007/s00204-020-02963-4
ER  - 

@article{
author = "Todorović Vukotić, Nevena and Đorđević, Jelena and Pejić, Snežana and Đorđević, Neda O. and Pajović, Snežana B.",
year = "2021",
abstract = "Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.",
journal = "Archives of Toxicology",
title = "Antidepressants- and antipsychotics-induced hepatotoxicity",
volume = "95",
number = "3",
pages = "767-789",
doi = "10.1007/s00204-020-02963-4"
}

Todorović Vukotić, N., Đorđević, J., Pejić, S., Đorđević, N. O.,& Pajović, S. B.. (2021). Antidepressants- and antipsychotics-induced hepatotoxicity. in Archives of Toxicology, 95(3), 767-789.
https://doi.org/10.1007/s00204-020-02963-4

Todorović Vukotić N, Đorđević J, Pejić S, Đorđević NO, Pajović SB. Antidepressants- and antipsychotics-induced hepatotoxicity. in Archives of Toxicology. 2021;95(3):767-789.
doi:10.1007/s00204-020-02963-4 .

Todorović Vukotić, Nevena, Đorđević, Jelena, Pejić, Snežana, Đorđević, Neda O., Pajović, Snežana B., "Antidepressants- and antipsychotics-induced hepatotoxicity" in Archives of Toxicology, 95, no. 3 (2021):767-789,
https://doi.org/10.1007/s00204-020-02963-4 . .

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Pejić, Snežana
AU  - Grigorov, Ilijana
AU  - Nikolić, Gorana
AU  - Mitić-Ćulafić, Dragana
AU  - Dragićević, Milan
AU  - Đorđević, Jelena
AU  - Todorović Vukotić, Nevena
AU  - Đorđević, Neda O.
AU  - Todorović, Ana
AU  - Drakulić, Dunja R.
AU  - Veljković, Filip M.
AU  - Pajović, Snežana B.
AU  - Todorović, Zoran
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9831
AB  - Thioacetamide (TAA) is widely used to study liver toxicity accompanied by oxidative stress, inflammation, cell necrosis, fibrosis, cholestasis, and hepatocellular carcinoma. As an efficient free radical’s scavenger, C60 fullerene is considered a potential liver-protective agent in chemically-induced liver injury. In the present work, we examined the hepatoprotective effects of two C60 doses dissolved in virgin olive oil against TAA-induced hepatotoxicity in rats. We showed that TAA-induced increase in liver oxidative stress, judged by the changes in the activities of SOD, CAT, GPx, GR, GST, the content of GSH and 4-HNE, and expression of HO-1, MnSOD, and CuZnSOD, was more effectively ameliorated with a lower C60 dose. Improvement in liver antioxidative status caused by C60 was accompanied by a decrease in liver HMGB1 expression and an increase in nuclear Nrf2/NF-κB p65 ratio, suggesting a reduction in inflammation, necrosis and fibrosis. These results were in accordance with liver histology analysis, liver comet assay, and changes in serum levels of ALT, AST, and AP. The changes observed in gut microbiome support detrimental effects of TAA and hepatoprotective effects of low C60 dose. Less protective effects of a higher C60 dose could be a consequence of its enhanced aggregation and related pro-oxidant role.
T2  - Antioxidants
T1  - Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes
VL  - 10
IS  - 6
SP  - 911
DO  - 10.3390/antiox10060911
ER  - 

@article{
author = "Đurašević, Siniša and Pejić, Snežana and Grigorov, Ilijana and Nikolić, Gorana and Mitić-Ćulafić, Dragana and Dragićević, Milan and Đorđević, Jelena and Todorović Vukotić, Nevena and Đorđević, Neda O. and Todorović, Ana and Drakulić, Dunja R. and Veljković, Filip M. and Pajović, Snežana B. and Todorović, Zoran",
year = "2021",
abstract = "Thioacetamide (TAA) is widely used to study liver toxicity accompanied by oxidative stress, inflammation, cell necrosis, fibrosis, cholestasis, and hepatocellular carcinoma. As an efficient free radical’s scavenger, C60 fullerene is considered a potential liver-protective agent in chemically-induced liver injury. In the present work, we examined the hepatoprotective effects of two C60 doses dissolved in virgin olive oil against TAA-induced hepatotoxicity in rats. We showed that TAA-induced increase in liver oxidative stress, judged by the changes in the activities of SOD, CAT, GPx, GR, GST, the content of GSH and 4-HNE, and expression of HO-1, MnSOD, and CuZnSOD, was more effectively ameliorated with a lower C60 dose. Improvement in liver antioxidative status caused by C60 was accompanied by a decrease in liver HMGB1 expression and an increase in nuclear Nrf2/NF-κB p65 ratio, suggesting a reduction in inflammation, necrosis and fibrosis. These results were in accordance with liver histology analysis, liver comet assay, and changes in serum levels of ALT, AST, and AP. The changes observed in gut microbiome support detrimental effects of TAA and hepatoprotective effects of low C60 dose. Less protective effects of a higher C60 dose could be a consequence of its enhanced aggregation and related pro-oxidant role.",
journal = "Antioxidants",
title = "Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes",
volume = "10",
number = "6",
pages = "911",
doi = "10.3390/antiox10060911"
}

Đurašević, S., Pejić, S., Grigorov, I., Nikolić, G., Mitić-Ćulafić, D., Dragićević, M., Đorđević, J., Todorović Vukotić, N., Đorđević, N. O., Todorović, A., Drakulić, D. R., Veljković, F. M., Pajović, S. B.,& Todorović, Z.. (2021). Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes. in Antioxidants, 10(6), 911.
https://doi.org/10.3390/antiox10060911

Đurašević S, Pejić S, Grigorov I, Nikolić G, Mitić-Ćulafić D, Dragićević M, Đorđević J, Todorović Vukotić N, Đorđević NO, Todorović A, Drakulić DR, Veljković FM, Pajović SB, Todorović Z. Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes. in Antioxidants. 2021;10(6):911.
doi:10.3390/antiox10060911 .

Đurašević, Siniša, Pejić, Snežana, Grigorov, Ilijana, Nikolić, Gorana, Mitić-Ćulafić, Dragana, Dragićević, Milan, Đorđević, Jelena, Todorović Vukotić, Nevena, Đorđević, Neda O., Todorović, Ana, Drakulić, Dunja R., Veljković, Filip M., Pajović, Snežana B., Todorović, Zoran, "Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes" in Antioxidants, 10, no. 6 (2021):911,
https://doi.org/10.3390/antiox10060911 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Todorović, Nevena
AU  - Novaković, Irena T.
AU  - Pezo, Lato
AU  - Pejin, Boris
AU  - Maraš, Vesna
AU  - Tešević, Vele V.
AU  - Pajović, Snežana B.
PY  - 2018
UR  - http://www.mdpi.com/1420-3049/23/8/1971
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7858
AB  - Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H2O2–stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions. The same trend was observed for catechin and gallic acid, the most abundant phenolics in the examined wine samples. Finally, the findings of an Artificial Neural Network (ANN) model were in a good agreement (r2 = 0.978) with the experimental data. All tested samples exhibited a protective effect in H2O2–stressed yeast cells. Pre-treatment with examined wines increased survival in H2O2–stressed cells and shifted antioxidative defense towards GPx–mediated defense. Finally, sensitivity analysis of obtained ANN model highlights the complexity of the impact that variations in the concentrations of specific phenolic components have on the antioxidant defense system.
T2  - Molecules
T1  - Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine
VL  - 23
IS  - 8
SP  - 1971
DO  - 10.3390/molecules23081971
ER  - 

@article{
author = "Đorđević, Neda O. and Todorović, Nevena and Novaković, Irena T. and Pezo, Lato and Pejin, Boris and Maraš, Vesna and Tešević, Vele V. and Pajović, Snežana B.",
year = "2018",
abstract = "Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H2O2–stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions. The same trend was observed for catechin and gallic acid, the most abundant phenolics in the examined wine samples. Finally, the findings of an Artificial Neural Network (ANN) model were in a good agreement (r2 = 0.978) with the experimental data. All tested samples exhibited a protective effect in H2O2–stressed yeast cells. Pre-treatment with examined wines increased survival in H2O2–stressed cells and shifted antioxidative defense towards GPx–mediated defense. Finally, sensitivity analysis of obtained ANN model highlights the complexity of the impact that variations in the concentrations of specific phenolic components have on the antioxidant defense system.",
journal = "Molecules",
title = "Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine",
volume = "23",
number = "8",
pages = "1971",
doi = "10.3390/molecules23081971"
}

Đorđević, N. O., Todorović, N., Novaković, I. T., Pezo, L., Pejin, B., Maraš, V., Tešević, V. V.,& Pajović, S. B.. (2018). Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine. in Molecules, 23(8), 1971.
https://doi.org/10.3390/molecules23081971

Đorđević NO, Todorović N, Novaković IT, Pezo L, Pejin B, Maraš V, Tešević VV, Pajović SB. Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine. in Molecules. 2018;23(8):1971.
doi:10.3390/molecules23081971 .

Đorđević, Neda O., Todorović, Nevena, Novaković, Irena T., Pezo, Lato, Pejin, Boris, Maraš, Vesna, Tešević, Vele V., Pajović, Snežana B., "Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine" in Molecules, 23, no. 8 (2018):1971,
https://doi.org/10.3390/molecules23081971 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Živković, Marijana B.
AU  - Savić, Aleksandar
AU  - Mutić, Jelena J.
AU  - Tešević, Vele
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1923
AB  - This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.
T2  - Scientia Horticulturae
T1  - An insight into chemical composition and biological activity of Montenegrin Vranac red wine
VL  - 230
SP  - 142
EP  - 148
DO  - 10.1016/j.scienta.2017.11.033
ER  - 

@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Živković, Marijana B. and Savić, Aleksandar and Mutić, Jelena J. and Tešević, Vele",
year = "2018",
abstract = "This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.",
journal = "Scientia Horticulturae",
title = "An insight into chemical composition and biological activity of Montenegrin Vranac red wine",
volume = "230",
pages = "142-148",
doi = "10.1016/j.scienta.2017.11.033"
}

Đorđević, N. O., Novaković, M. M., Pejin, B., Živković, M. B., Savić, A., Mutić, J. J.,& Tešević, V.. (2018). An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae, 230, 142-148.
https://doi.org/10.1016/j.scienta.2017.11.033

Đorđević NO, Novaković MM, Pejin B, Živković MB, Savić A, Mutić JJ, Tešević V. An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae. 2018;230:142-148.
doi:10.1016/j.scienta.2017.11.033 .

Đorđević, Neda O., Novaković, Miroslav M., Pejin, Boris, Živković, Marijana B., Savić, Aleksandar, Mutić, Jelena J., Tešević, Vele, "An insight into chemical composition and biological activity of Montenegrin Vranac red wine" in Scientia Horticulturae, 230 (2018):142-148,
https://doi.org/10.1016/j.scienta.2017.11.033 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor M.
AU  - Mutić, Jelena J.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1863
AB  - The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.
T2  - Natural Product Research
T1  - Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro
VL  - 32
IS  - 3
SP  - 247
EP  - 251
DO  - 10.1080/14786419.2017.1347171
ER  - 

@article{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor M. and Mutić, Jelena J. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2018",
abstract = "The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.",
journal = "Natural Product Research",
title = "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro",
volume = "32",
number = "3",
pages = "247-251",
doi = "10.1080/14786419.2017.1347171"
}

Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D. M., Mutić, J. J., Pajović, S. B.,& Tešević, V. V.. (2018). Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro. in Natural Product Research, 32(3), 247-251.
https://doi.org/10.1080/14786419.2017.1347171

Đorđević NO, Pejin B, Novaković MM, Stanković DM, Mutić JJ, Pajović SB, Tešević VV. Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro. in Natural Product Research. 2018;32(3):247-251.
doi:10.1080/14786419.2017.1347171 .

Đorđević, Neda O., Pejin, Boris, Novaković, Miroslav M., Stanković, Dalibor M., Mutić, Jelena J., Pajović, Snežana B., Tešević, Vele V., "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro" in Natural Product Research, 32, no. 3 (2018):247-251,
https://doi.org/10.1080/14786419.2017.1347171 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor M.
AU  - Mutić, Jelena J.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1773
AB  - The overall aim was to compare the quality of two Montenegrin Merlot wines obtained from new vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011, due to preliminary screening of the potential of novel Merlot vine clones for the wine industry. The content of phenolic compounds was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). Elemental composition was analysed using inductively coupled plasma optical emission spectrometery (ICP-OES) and inductively coupled plasma mass spectrometery (ICP-MS)]. Additionaly, antioxidant capacity was assessed by cyclic voltammetry. Compared with the commercial one, both wine clones contained higher percent of major phenolic compounds (namely, gallic acid and catechin) with top values recorded for VCR1 both in 2010 (30.46 +/- 0.42 mg/1) and 2011 (28.12 +/- 0.29 mg/1). The same wines were enriched with epicatechin, resveratrol, myricetin and quercetin. Furthermore, VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, both new Montenegrin Merlot wines represent good candidates for the commercialised wines with an indication of geographical origin.
T2  - Scientia Horticulturae
T1  - Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro
VL  - 225
SP  - 505
EP  - 511
DO  - 10.1016/j.scienta.2017.07.045
ER  - 

@article{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor M. and Mutić, Jelena J. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2017",
abstract = "The overall aim was to compare the quality of two Montenegrin Merlot wines obtained from new vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011, due to preliminary screening of the potential of novel Merlot vine clones for the wine industry. The content of phenolic compounds was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). Elemental composition was analysed using inductively coupled plasma optical emission spectrometery (ICP-OES) and inductively coupled plasma mass spectrometery (ICP-MS)]. Additionaly, antioxidant capacity was assessed by cyclic voltammetry. Compared with the commercial one, both wine clones contained higher percent of major phenolic compounds (namely, gallic acid and catechin) with top values recorded for VCR1 both in 2010 (30.46 +/- 0.42 mg/1) and 2011 (28.12 +/- 0.29 mg/1). The same wines were enriched with epicatechin, resveratrol, myricetin and quercetin. Furthermore, VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, both new Montenegrin Merlot wines represent good candidates for the commercialised wines with an indication of geographical origin.",
journal = "Scientia Horticulturae",
title = "Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro",
volume = "225",
pages = "505-511",
doi = "10.1016/j.scienta.2017.07.045"
}

Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D. M., Mutić, J. J., Pajović, S. B.,& Tešević, V. V.. (2017). Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro. in Scientia Horticulturae, 225, 505-511.
https://doi.org/10.1016/j.scienta.2017.07.045

Đorđević NO, Pejin B, Novaković MM, Stanković DM, Mutić JJ, Pajović SB, Tešević VV. Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro. in Scientia Horticulturae. 2017;225:505-511.
doi:10.1016/j.scienta.2017.07.045 .

Đorđević, Neda O., Pejin, Boris, Novaković, Miroslav M., Stanković, Dalibor M., Mutić, Jelena J., Pajović, Snežana B., Tešević, Vele V., "Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro" in Scientia Horticulturae, 225 (2017):505-511,
https://doi.org/10.1016/j.scienta.2017.07.045 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Mutić, Jelena J.
AU  - Vajs, Vlatka E.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1628
AB  - Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .
T2  - Natural Product Research
T1  - Comparative analytical study of the selected wine varieties grown in Montenegro
VL  - 31
IS  - 15
SP  - 1825
EP  - 1830
DO  - 10.1080/14786419.2017.1289209
ER  - 

@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Mutić, Jelena J. and Vajs, Vlatka E. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2017",
abstract = "Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .",
journal = "Natural Product Research",
title = "Comparative analytical study of the selected wine varieties grown in Montenegro",
volume = "31",
number = "15",
pages = "1825-1830",
doi = "10.1080/14786419.2017.1289209"
}

Đorđević, N. O., Novaković, M. M., Pejin, B., Mutić, J. J., Vajs, V. E., Pajović, S. B.,& Tešević, V. V.. (2017). Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research, 31(15), 1825-1830.
https://doi.org/10.1080/14786419.2017.1289209

Đorđević NO, Novaković MM, Pejin B, Mutić JJ, Vajs VE, Pajović SB, Tešević VV. Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research. 2017;31(15):1825-1830.
doi:10.1080/14786419.2017.1289209 .

Đorđević, Neda O., Novaković, Miroslav M., Pejin, Boris, Mutić, Jelena J., Vajs, Vlatka E., Pajović, Snežana B., Tešević, Vele V., "Comparative analytical study of the selected wine varieties grown in Montenegro" in Natural Product Research, 31, no. 15 (2017):1825-1830,
https://doi.org/10.1080/14786419.2017.1289209 . .

TY  - CONF
AU  - Perić, Ivana
AU  - Todorović, Nevena
AU  - Stanisavljević, Andrijana
AU  - Đorđević, Neda O.
AU  - Filipović, Dragana
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9200
AB  - Exposure   of   an   organism   to   chronic   social   isolation   (CSIS)   causes modulation  of  antioxidant  defense  system  in  the  brain  which  has  been shown to have important role in depression. Fluoxetine (Flx) is the first-line treatment  for  depression;  however,  precise  mechanism  of  its  action  still remains  elusive.  The  aim  of  this  study  was  to  investigate  the  effect  of  3 weeks  of  Flx  treatment  on  malondialdehyde  (MDA)  level,  an  oxidative stress parameter as well as on the activities of GSH-dependent antioxidative enzymes in the hippocampus of rats exposed to 6 weeks of CSIS. Increased MDA content following  CSIS and Flx treatment  (controls or CSIS) of rats, suggests  on  hippocampal  oxidative  damage.  CSIS  induced  reduction  of hippocampal  glutathione-S-transferase  that  was  reversed  by  Flx  treatment, as  well  as  an  increase  in  glutathione  peroxidase/reductase  activities.  The present  study  contributes  to  our  understanding  of  the  mechanisms  that underlie the antidepressant activity of Flx in rats exposed to CSIS, an animal model of depression.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
T1  - The effects of fluoxetine on hippocampal antioxidative defense in depressive-like rats
SP  - 435
EP  - 438
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9200
ER  - 

@conference{
author = "Perić, Ivana and Todorović, Nevena and Stanisavljević, Andrijana and Đorđević, Neda O. and Filipović, Dragana",
year = "2016",
abstract = "Exposure   of   an   organism   to   chronic   social   isolation   (CSIS)   causes modulation  of  antioxidant  defense  system  in  the  brain  which  has  been shown to have important role in depression. Fluoxetine (Flx) is the first-line treatment  for  depression;  however,  precise  mechanism  of  its  action  still remains  elusive.  The  aim  of  this  study  was  to  investigate  the  effect  of  3 weeks  of  Flx  treatment  on  malondialdehyde  (MDA)  level,  an  oxidative stress parameter as well as on the activities of GSH-dependent antioxidative enzymes in the hippocampus of rats exposed to 6 weeks of CSIS. Increased MDA content following  CSIS and Flx treatment  (controls or CSIS) of rats, suggests  on  hippocampal  oxidative  damage.  CSIS  induced  reduction  of hippocampal  glutathione-S-transferase  that  was  reversed  by  Flx  treatment, as  well  as  an  increase  in  glutathione  peroxidase/reductase  activities.  The present  study  contributes  to  our  understanding  of  the  mechanisms  that underlie the antidepressant activity of Flx in rats exposed to CSIS, an animal model of depression.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry",
title = "The effects of fluoxetine on hippocampal antioxidative defense in depressive-like rats",
pages = "435-438",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9200"
}

Perić, I., Todorović, N., Stanisavljević, A., Đorđević, N. O.,& Filipović, D.. (2016). The effects of fluoxetine on hippocampal antioxidative defense in depressive-like rats. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 435-438.
https://hdl.handle.net/21.15107/rcub_vinar_9200

Perić I, Todorović N, Stanisavljević A, Đorđević NO, Filipović D. The effects of fluoxetine on hippocampal antioxidative defense in depressive-like rats. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:435-438.
https://hdl.handle.net/21.15107/rcub_vinar_9200 .

Perić, Ivana, Todorović, Nevena, Stanisavljević, Andrijana, Đorđević, Neda O., Filipović, Dragana, "The effects of fluoxetine on hippocampal antioxidative defense in depressive-like rats" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):435-438,
https://hdl.handle.net/21.15107/rcub_vinar_9200 .

TY  - CONF
AU  - Stanisavljević, Andrijana
AU  - Perić, Ivana
AU  - Todorović, Nevena
AU  - Đorđević, Neda O.
AU  - Filipović, Dragana
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9203
AB  - Olanzapine  is  an  antipsychotic  proved  to  be  effective  in stress  associated psychiatric diseases, but its effect on the liver, main site of drug metabolism,still  remain  unclear.  We  investigated  the  effects  of  chronic  treatment  of olanzapine   (three-week)   on   the   malondialdehyde   (MDA)   content   and protein expression and activity of antioxidant enzyme catalase (CAT) in the liver of rats exposed to chronic social isolation (CSIS) (six-week), an animal model of depression. The increased cytosolic MDA content in both vehicle-and  olanzapine-treated  CSIS  animals  suggests  oxidative  stress. Increased CAT  activityin  vehicle-treated  CSIS  animals,  which  was  not  consistent with   its   protein   expression,   suggests   induction   of   antioxidant   defense mechanisms,while  olanzapine  significantly  reduced  CAT  activity  in  CSIS group.   Data   revealed   that   although   olanzapine   treatment   reversed   the alterations  in  CAT  activity,  it  has the  ability  to  cause  hepatotoxicity,  as indicatedby increased MDA content.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
T1  - Olanzapine intensifies lipid peroxidation and modulates catalase activity in liver of social isolated rats
SP  - 439
EP  - 442
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9203
ER  - 

@conference{
author = "Stanisavljević, Andrijana and Perić, Ivana and Todorović, Nevena and Đorđević, Neda O. and Filipović, Dragana",
year = "2016",
abstract = "Olanzapine  is  an  antipsychotic  proved  to  be  effective  in stress  associated psychiatric diseases, but its effect on the liver, main site of drug metabolism,still  remain  unclear.  We  investigated  the  effects  of  chronic  treatment  of olanzapine   (three-week)   on   the   malondialdehyde   (MDA)   content   and protein expression and activity of antioxidant enzyme catalase (CAT) in the liver of rats exposed to chronic social isolation (CSIS) (six-week), an animal model of depression. The increased cytosolic MDA content in both vehicle-and  olanzapine-treated  CSIS  animals  suggests  oxidative  stress. Increased CAT  activityin  vehicle-treated  CSIS  animals,  which  was  not  consistent with   its   protein   expression,   suggests   induction   of   antioxidant   defense mechanisms,while  olanzapine  significantly  reduced  CAT  activity  in  CSIS group.   Data   revealed   that   although   olanzapine   treatment   reversed   the alterations  in  CAT  activity,  it  has the  ability  to  cause  hepatotoxicity,  as indicatedby increased MDA content.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry",
title = "Olanzapine intensifies lipid peroxidation and modulates catalase activity in liver of social isolated rats",
pages = "439-442",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9203"
}

Stanisavljević, A., Perić, I., Todorović, N., Đorđević, N. O.,& Filipović, D.. (2016). Olanzapine intensifies lipid peroxidation and modulates catalase activity in liver of social isolated rats. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 439-442.
https://hdl.handle.net/21.15107/rcub_vinar_9203

Stanisavljević A, Perić I, Todorović N, Đorđević NO, Filipović D. Olanzapine intensifies lipid peroxidation and modulates catalase activity in liver of social isolated rats. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:439-442.
https://hdl.handle.net/21.15107/rcub_vinar_9203 .

Stanisavljević, Andrijana, Perić, Ivana, Todorović, Nevena, Đorđević, Neda O., Filipović, Dragana, "Olanzapine intensifies lipid peroxidation and modulates catalase activity in liver of social isolated rats" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):439-442,
https://hdl.handle.net/21.15107/rcub_vinar_9203 .

TY  - CONF
AU  - Đorđević, Neda O.
AU  - Perić, Ivana
AU  - Stanisavljević, Andrijana
AU  - Todorović, Nevena
AU  - Filipović, Dragana
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9205
AB  - Duloxetine  (DLX)  is  antidepressantfor  the  treatment  of  depression,but  its effect  on  the  liver,  a  primary  site  for  drug  metabolism,  has  yet  to  be determined.The  effect  of  3  weeks  of  DLX  treatment  onprotein  carbonyl groups   and   activities   of   GSH-dependent   defense   including   reduced glutathione   (GSH),   glutathione   peroxidase   (GPx)   and   glutathione   S-transferase  (GST)  in  liver  of  rats  exposed  to  6  weeks  of  chronic  social isolation  (CSIS),  an  animal  model  of  depression,  were  investigated.  CSIS induced increase in protein carbonyl content, which wasdecreasedby DLX treatment.  We  noticed  increase  in  GPx  and  GST  activity  in  DLX-treated (controls  and  CSIS)  rats  and  CSIS  group,  whereby  GPx  activity  was significantly higher in DLX-compared to vehicle-treatedCSIS rats. Results indicate protective effect of DLX against CSIS-induced oxidative damage of hepatic  proteins,  which  may  be  due  to  intensified  protective  mechanisms mediated by GSH-dependent defense.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
T1  - Duloxetine enhances hepatic gsh-dependent defense in rats
SP  - 443
EP  - 446
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9205
ER  - 

@conference{
author = "Đorđević, Neda O. and Perić, Ivana and Stanisavljević, Andrijana and Todorović, Nevena and Filipović, Dragana",
year = "2016",
abstract = "Duloxetine  (DLX)  is  antidepressantfor  the  treatment  of  depression,but  its effect  on  the  liver,  a  primary  site  for  drug  metabolism,  has  yet  to  be determined.The  effect  of  3  weeks  of  DLX  treatment  onprotein  carbonyl groups   and   activities   of   GSH-dependent   defense   including   reduced glutathione   (GSH),   glutathione   peroxidase   (GPx)   and   glutathione   S-transferase  (GST)  in  liver  of  rats  exposed  to  6  weeks  of  chronic  social isolation  (CSIS),  an  animal  model  of  depression,  were  investigated.  CSIS induced increase in protein carbonyl content, which wasdecreasedby DLX treatment.  We  noticed  increase  in  GPx  and  GST  activity  in  DLX-treated (controls  and  CSIS)  rats  and  CSIS  group,  whereby  GPx  activity  was significantly higher in DLX-compared to vehicle-treatedCSIS rats. Results indicate protective effect of DLX against CSIS-induced oxidative damage of hepatic  proteins,  which  may  be  due  to  intensified  protective  mechanisms mediated by GSH-dependent defense.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry",
title = "Duloxetine enhances hepatic gsh-dependent defense in rats",
pages = "443-446",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9205"
}

Đorđević, N. O., Perić, I., Stanisavljević, A., Todorović, N.,& Filipović, D.. (2016). Duloxetine enhances hepatic gsh-dependent defense in rats. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 443-446.
https://hdl.handle.net/21.15107/rcub_vinar_9205

Đorđević NO, Perić I, Stanisavljević A, Todorović N, Filipović D. Duloxetine enhances hepatic gsh-dependent defense in rats. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:443-446.
https://hdl.handle.net/21.15107/rcub_vinar_9205 .

Đorđević, Neda O., Perić, Ivana, Stanisavljević, Andrijana, Todorović, Nevena, Filipović, Dragana, "Duloxetine enhances hepatic gsh-dependent defense in rats" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):443-446,
https://hdl.handle.net/21.15107/rcub_vinar_9205 .