TY  - JOUR
AU  - Gluvić, Zoran
AU  - Tica, Jelena S.
AU  - Vujović, Marina V.
AU  - Rašić-Milutinović, Zorica R.
AU  - Popović-Radinović, Vesna
AU  - Lačković, Milena M.
AU  - Trpković, Andreja T.
AU  - Isenović, Esma R.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10328
AB  - Subklinički hipotiroidizam je asimptomatska ili simptomatska tiroidna disfunkcija, koja se karakteriše umerenim porastom nivoa TSH i normalnim nivoima perifernih tiroidnih hormona. Često se otkriva uzgredno. Etiologija subkliničkog hipotiroidizma je identična etiologiji kliničkog hipotiroidizma. Dijagnostikuje se laboratorijski, određivanjem nivoa TSH i perifernih tirodnih frakcija. S'obzirom da je od kliničkog značaja samo perzistentni subklinički hipotiroidizam, za definitivnu potvrdu je neophodno učiniti hormonsku reevaluaciju 6-12 meseci nakon incijalne. Značaj subkliničkog hipotiroidizma je prevashodno u postojanju određenih propratnih pojava, koje mogu značajno uticati na kvalitet života bolesnika (dislipidemija, kardiovaskularni i neurokognitivni poremećaji, infertilitet, poremećaj intrauterinog razvoja ploda). Upravo stoga, lečenje subkliničkog hipotiroidizma malim dozama levotiroksina treba sprovesti u slučajevima gde je korist od supstitucije daleko veća od njenih potencijalnih rizika. Ovaj revijski rad je pokušaj argumentovanog razmatranja kliničkih i terapijskih aspekata subkliničkog hipotiroidizma iz literature i našeg kliničkog iskustva.
AB  - Subclinical hypothyroidism is asymptomatic or symptomatic thyroid dysfunction, presented as slightly elevated TSH level and reference range values of peripheral thyroid hormons. Its etiology is the same as the etiology of clinical hypothyroidism. By measurement of TSH serum level as well the levels of peripheral free thyroid hormone fractions, it is easy, but more frequently incidental, diagnosed. Because of clinical significance is just persistent subclinical hypothyroidism, obliged hormonal confirmation would be done 6-12 months after initial measurement. The importance of subclinical hypothyroidism lay in the co-existence of some accompanying phenomenons, which can significantly influence on the patients life quality (lipid disorders, cardiovascular and neurocognitive dysfunctions, infertility, inadequate fetal growth and deveolpment). For such reasons, it is necessary to substitute subclinical hypothyroidism with small doses of levothyroxine, where we can expect more benefit than the risk of therapy. This review article is an attempt to unite present important clinical and therapeutical aspects of subclinical hypothyroidism from reviews and our experience.
T2  - Materia medica
T1  - Subklinički hipotiroidizam
T1  - Subclinical hypothyroidism
VL  - 26
IS  - 3
SP  - 95
EP  - 100
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10328
ER  - 

@article{
author = "Gluvić, Zoran and Tica, Jelena S. and Vujović, Marina V. and Rašić-Milutinović, Zorica R. and Popović-Radinović, Vesna and Lačković, Milena M. and Trpković, Andreja T. and Isenović, Esma R.",
year = "2010",
abstract = "Subklinički hipotiroidizam je asimptomatska ili simptomatska tiroidna disfunkcija, koja se karakteriše umerenim porastom nivoa TSH i normalnim nivoima perifernih tiroidnih hormona. Često se otkriva uzgredno. Etiologija subkliničkog hipotiroidizma je identična etiologiji kliničkog hipotiroidizma. Dijagnostikuje se laboratorijski, određivanjem nivoa TSH i perifernih tirodnih frakcija. S'obzirom da je od kliničkog značaja samo perzistentni subklinički hipotiroidizam, za definitivnu potvrdu je neophodno učiniti hormonsku reevaluaciju 6-12 meseci nakon incijalne. Značaj subkliničkog hipotiroidizma je prevashodno u postojanju određenih propratnih pojava, koje mogu značajno uticati na kvalitet života bolesnika (dislipidemija, kardiovaskularni i neurokognitivni poremećaji, infertilitet, poremećaj intrauterinog razvoja ploda). Upravo stoga, lečenje subkliničkog hipotiroidizma malim dozama levotiroksina treba sprovesti u slučajevima gde je korist od supstitucije daleko veća od njenih potencijalnih rizika. Ovaj revijski rad je pokušaj argumentovanog razmatranja kliničkih i terapijskih aspekata subkliničkog hipotiroidizma iz literature i našeg kliničkog iskustva., Subclinical hypothyroidism is asymptomatic or symptomatic thyroid dysfunction, presented as slightly elevated TSH level and reference range values of peripheral thyroid hormons. Its etiology is the same as the etiology of clinical hypothyroidism. By measurement of TSH serum level as well the levels of peripheral free thyroid hormone fractions, it is easy, but more frequently incidental, diagnosed. Because of clinical significance is just persistent subclinical hypothyroidism, obliged hormonal confirmation would be done 6-12 months after initial measurement. The importance of subclinical hypothyroidism lay in the co-existence of some accompanying phenomenons, which can significantly influence on the patients life quality (lipid disorders, cardiovascular and neurocognitive dysfunctions, infertility, inadequate fetal growth and deveolpment). For such reasons, it is necessary to substitute subclinical hypothyroidism with small doses of levothyroxine, where we can expect more benefit than the risk of therapy. This review article is an attempt to unite present important clinical and therapeutical aspects of subclinical hypothyroidism from reviews and our experience.",
journal = "Materia medica",
title = "Subklinički hipotiroidizam, Subclinical hypothyroidism",
volume = "26",
number = "3",
pages = "95-100",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10328"
}

Gluvić, Z., Tica, J. S., Vujović, M. V., Rašić-Milutinović, Z. R., Popović-Radinović, V., Lačković, M. M., Trpković, A. T.,& Isenović, E. R.. (2010). Subklinički hipotiroidizam. in Materia medica, 26(3), 95-100.
https://hdl.handle.net/21.15107/rcub_vinar_10328

Gluvić Z, Tica JS, Vujović MV, Rašić-Milutinović ZR, Popović-Radinović V, Lačković MM, Trpković AT, Isenović ER. Subklinički hipotiroidizam. in Materia medica. 2010;26(3):95-100.
https://hdl.handle.net/21.15107/rcub_vinar_10328 .

Gluvić, Zoran, Tica, Jelena S., Vujović, Marina V., Rašić-Milutinović, Zorica R., Popović-Radinović, Vesna, Lačković, Milena M., Trpković, Andreja T., Isenović, Esma R., "Subklinički hipotiroidizam" in Materia medica, 26, no. 3 (2010):95-100,
https://hdl.handle.net/21.15107/rcub_vinar_10328 .