TY  - CONF
AU  - Živković, Maja
AU  - Kostić, S.
AU  - Stojković, Ljiljana
AU  - Kolić, Ivana
AU  - Stanković, Aleksandra
AU  - Dinčić, E.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12466
AB  - Last decade provided multiple evidence that link disturbances in metabolic processes and energy metabolism with diseases of central nervous system and neurodegeneration. Initial phases of insulin resistance (IR) are present in natural course of multiple sclerosis (MS) and leptin was recognized as a player in MS pathophysiology and moreover cognitive decline. We aimed to investigate association of genetic variants in leptin (LEP) rs7799039, its receptor LEPR rs1137101 and proliferator-activated receptor gamma co-activator 1-alpha (PGCA1A) rs8192678 with IR parameters (HOMA-IR index, area under the curve for insulin and glucose, Cederholm insulin sensitivity index (ISIced), the insulinogenic index in the first 30 min of oral glucose tolerance test (OGTT) in patients with MS. Seventy eight relapsing-remitting patients in clinical remission, free of corticosteroids for at least three months, were included in the study. None of the 3 variants’ genotypes were associated with HOMA-IR index, area under the curve for insulin and glucose and the insulinogenic index in the first 30 min of OGTT. PGC1A variant was significantly associated with ISIced (Kruskal-Wallis ANOVA, p = 0.04). Leptin gene variant was significantly associated with impaired GT (p=0.029 adjusted for gender and other two variants). None of the variant showed association with IR. In conclusion, we found that genetic variants in leptin signalling pathway affect glucose tolerance and insulin sensitivity in patients with MS. As both, leptin and PGC1A have role in preventing neuronal death and reducing oxidative stress neuronal damage current results favour further investigation toward preserving cognitive status and neuroprotection in MS.
C3  - CONy : 17th World Congress on Controversies in Neurology : Abstract book
T1  - Leptin signalling genetic variants and insulin resistance in multiple sclerosis patients
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12466
ER  - 

@conference{
author = "Živković, Maja and Kostić, S. and Stojković, Ljiljana and Kolić, Ivana and Stanković, Aleksandra and Dinčić, E.",
year = "2023",
abstract = "Last decade provided multiple evidence that link disturbances in metabolic processes and energy metabolism with diseases of central nervous system and neurodegeneration. Initial phases of insulin resistance (IR) are present in natural course of multiple sclerosis (MS) and leptin was recognized as a player in MS pathophysiology and moreover cognitive decline. We aimed to investigate association of genetic variants in leptin (LEP) rs7799039, its receptor LEPR rs1137101 and proliferator-activated receptor gamma co-activator 1-alpha (PGCA1A) rs8192678 with IR parameters (HOMA-IR index, area under the curve for insulin and glucose, Cederholm insulin sensitivity index (ISIced), the insulinogenic index in the first 30 min of oral glucose tolerance test (OGTT) in patients with MS. Seventy eight relapsing-remitting patients in clinical remission, free of corticosteroids for at least three months, were included in the study. None of the 3 variants’ genotypes were associated with HOMA-IR index, area under the curve for insulin and glucose and the insulinogenic index in the first 30 min of OGTT. PGC1A variant was significantly associated with ISIced (Kruskal-Wallis ANOVA, p = 0.04). Leptin gene variant was significantly associated with impaired GT (p=0.029 adjusted for gender and other two variants). None of the variant showed association with IR. In conclusion, we found that genetic variants in leptin signalling pathway affect glucose tolerance and insulin sensitivity in patients with MS. As both, leptin and PGC1A have role in preventing neuronal death and reducing oxidative stress neuronal damage current results favour further investigation toward preserving cognitive status and neuroprotection in MS.",
journal = "CONy : 17th World Congress on Controversies in Neurology : Abstract book",
title = "Leptin signalling genetic variants and insulin resistance in multiple sclerosis patients",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12466"
}

Živković, M., Kostić, S., Stojković, L., Kolić, I., Stanković, A.,& Dinčić, E.. (2023). Leptin signalling genetic variants and insulin resistance in multiple sclerosis patients. in CONy : 17th World Congress on Controversies in Neurology : Abstract book.
https://hdl.handle.net/21.15107/rcub_vinar_12466

Živković M, Kostić S, Stojković L, Kolić I, Stanković A, Dinčić E. Leptin signalling genetic variants and insulin resistance in multiple sclerosis patients. in CONy : 17th World Congress on Controversies in Neurology : Abstract book. 2023;.
https://hdl.handle.net/21.15107/rcub_vinar_12466 .

Živković, Maja, Kostić, S., Stojković, Ljiljana, Kolić, Ivana, Stanković, Aleksandra, Dinčić, E., "Leptin signalling genetic variants and insulin resistance in multiple sclerosis patients" in CONy : 17th World Congress on Controversies in Neurology : Abstract book (2023),
https://hdl.handle.net/21.15107/rcub_vinar_12466 .

TY  - CONF
AU  - Đurić, Dragan
AU  - Mićović, Z.
AU  - Stamenković, A.
AU  - Jakovljević Uzelac, J.
AU  - Stojanović, M.
AU  - Šćepanović, Lj.
AU  - Mitrović, D.
AU  - Labudović Borović. M.
AU  - Krstić, Danijela
AU  - Čolović, Mirjana
AU  - Obrenović, R.
AU  - Hadžibegović, A.
AU  - Kostić, S.
AU  - Šobot, T.
AU  - Jakovljević, Vladimir
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12985
C3  - Joint meeting of national physiological societies "New perspectives in physiological research – young investigator forum"
T1  - Comparison of the effects of different sulfur amino acids on cardiovascular system in male wistar rats
SP  - 36
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12985
ER  - 

@conference{
author = "Đurić, Dragan and Mićović, Z. and Stamenković, A. and Jakovljević Uzelac, J. and Stojanović, M. and Šćepanović, Lj. and Mitrović, D. and Labudović Borović. M. and Krstić, Danijela and Čolović, Mirjana and Obrenović, R. and Hadžibegović, A. and Kostić, S. and Šobot, T. and Jakovljević, Vladimir",
year = "2017",
journal = "Joint meeting of national physiological societies "New perspectives in physiological research – young investigator forum"",
title = "Comparison of the effects of different sulfur amino acids on cardiovascular system in male wistar rats",
pages = "36-36",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12985"
}

Đurić, D., Mićović, Z., Stamenković, A., Jakovljević Uzelac, J., Stojanović, M., Šćepanović, Lj., Mitrović, D., Labudović Borović. M., Krstić, D., Čolović, M., Obrenović, R., Hadžibegović, A., Kostić, S., Šobot, T.,& Jakovljević, V.. (2017). Comparison of the effects of different sulfur amino acids on cardiovascular system in male wistar rats. in Joint meeting of national physiological societies "New perspectives in physiological research – young investigator forum", 36-36.
https://hdl.handle.net/21.15107/rcub_vinar_12985

Đurić D, Mićović Z, Stamenković A, Jakovljević Uzelac J, Stojanović M, Šćepanović L, Mitrović D, Labudović Borović. M., Krstić D, Čolović M, Obrenović R, Hadžibegović A, Kostić S, Šobot T, Jakovljević V. Comparison of the effects of different sulfur amino acids on cardiovascular system in male wistar rats. in Joint meeting of national physiological societies "New perspectives in physiological research – young investigator forum". 2017;:36-36.
https://hdl.handle.net/21.15107/rcub_vinar_12985 .

Đurić, Dragan, Mićović, Z., Stamenković, A., Jakovljević Uzelac, J., Stojanović, M., Šćepanović, Lj., Mitrović, D., Labudović Borović. M., Krstić, Danijela, Čolović, Mirjana, Obrenović, R., Hadžibegović, A., Kostić, S., Šobot, T., Jakovljević, Vladimir, "Comparison of the effects of different sulfur amino acids on cardiovascular system in male wistar rats" in Joint meeting of national physiological societies "New perspectives in physiological research – young investigator forum" (2017):36-36,
https://hdl.handle.net/21.15107/rcub_vinar_12985 .

TY  - CONF
AU  - Kostić, S.
AU  - Hadžibegović, A.
AU  - Čolović, Mirjana
AU  - Krstić, Danijela
AU  - Đurić, Dragan
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13009
C3  - 2nd Joint Meeting of Slovak and Serbian Physiological Societies "Physiology without frontiers" : Book of abstracts
T1  - Effects of acutely applied methionine on plasma oxidative stress markers and AchE activity in rat cardiac and brain tissue
SP  - 25
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13009
ER  - 

@conference{
author = "Kostić, S. and Hadžibegović, A. and Čolović, Mirjana and Krstić, Danijela and Đurić, Dragan",
year = "2016",
journal = "2nd Joint Meeting of Slovak and Serbian Physiological Societies "Physiology without frontiers" : Book of abstracts",
title = "Effects of acutely applied methionine on plasma oxidative stress markers and AchE activity in rat cardiac and brain tissue",
pages = "25-25",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13009"
}

Kostić, S., Hadžibegović, A., Čolović, M., Krstić, D.,& Đurić, D.. (2016). Effects of acutely applied methionine on plasma oxidative stress markers and AchE activity in rat cardiac and brain tissue. in 2nd Joint Meeting of Slovak and Serbian Physiological Societies "Physiology without frontiers" : Book of abstracts, 25-25.
https://hdl.handle.net/21.15107/rcub_vinar_13009

Kostić S, Hadžibegović A, Čolović M, Krstić D, Đurić D. Effects of acutely applied methionine on plasma oxidative stress markers and AchE activity in rat cardiac and brain tissue. in 2nd Joint Meeting of Slovak and Serbian Physiological Societies "Physiology without frontiers" : Book of abstracts. 2016;:25-25.
https://hdl.handle.net/21.15107/rcub_vinar_13009 .

Kostić, S., Hadžibegović, A., Čolović, Mirjana, Krstić, Danijela, Đurić, Dragan, "Effects of acutely applied methionine on plasma oxidative stress markers and AchE activity in rat cardiac and brain tissue" in 2nd Joint Meeting of Slovak and Serbian Physiological Societies "Physiology without frontiers" : Book of abstracts (2016):25-25,
https://hdl.handle.net/21.15107/rcub_vinar_13009 .