TY  - JOUR
AU  - Nešić, Maja D.
AU  - Dučić, Tanja
AU  - Gemović, Branislava
AU  - Senćanski, Milan
AU  - Algarra, Manuel
AU  - Gonçalves, Mara
AU  - Stepić, Milutin
AU  - Popović, Iva
AU  - Kapuran, Đorđe
AU  - Petković, Marijana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13575
AB  - We predicted the protein therapeutic targets specific to a Ru-based potential drug and its combination with pristine and N-doped carbon dot drug delivery systems, denoted as RuCN/CDs and RuCN/N-CDs. Synchrotron-based FTIR microspectroscopy (µFTIR) in addition to bioinformatics data on drug structures and protein sequences were applied to assess changes in the protein secondary structure of A2780 cancer cells. µFTIR revealed the moieties of the target proteins’ secondary structure changes only after the treatment with RuCN and RuCN/N-CDs. A higher content of α-helices and a lower content of β-sheets appeared in A2780 cells after RuCN treatment. Treatment with RuCN/N-CDs caused a substantial increase in parallel β-sheet numbers, random coil content, and tyrosine residue numbers. The results obtained suggest that the mitochondrion-related proteins NDUFA1 and NDUFB5 are affected by RuCN either via overexpression or stabilisation of helical structures. RuCN/N-CDs either induce overexpression of the β-sheet-rich protein NDUFS1 and affect its random coil structure or interact and stabilise its structure via hydrogen bonding between -NH2 groups from N-CDs with protein C=O groups and –OH groups of serine, threonine, and tyrosine residues. The N-CD nanocarrier tunes this drug’s action by directing it toward a specific protein target, changing this drug’s coordination ability and inducing changes in the protein’s secondary structures and function.
T2  - Pharmaceutics
T1  - Prediction of Protein Targets in Ovarian Cancer Using a Ru-Complex and Carbon Dot Drug Delivery Therapeutic Nanosystems: A Bioinformatics and μ-FTIR Spectroscopy Approach
VL  - 16
IS  - 8
SP  - 997
DO  - 10.3390/pharmaceutics16080997
ER  - 

@article{
author = "Nešić, Maja D. and Dučić, Tanja and Gemović, Branislava and Senćanski, Milan and Algarra, Manuel and Gonçalves, Mara and Stepić, Milutin and Popović, Iva and Kapuran, Đorđe and Petković, Marijana",
year = "2024",
abstract = "We predicted the protein therapeutic targets specific to a Ru-based potential drug and its combination with pristine and N-doped carbon dot drug delivery systems, denoted as RuCN/CDs and RuCN/N-CDs. Synchrotron-based FTIR microspectroscopy (µFTIR) in addition to bioinformatics data on drug structures and protein sequences were applied to assess changes in the protein secondary structure of A2780 cancer cells. µFTIR revealed the moieties of the target proteins’ secondary structure changes only after the treatment with RuCN and RuCN/N-CDs. A higher content of α-helices and a lower content of β-sheets appeared in A2780 cells after RuCN treatment. Treatment with RuCN/N-CDs caused a substantial increase in parallel β-sheet numbers, random coil content, and tyrosine residue numbers. The results obtained suggest that the mitochondrion-related proteins NDUFA1 and NDUFB5 are affected by RuCN either via overexpression or stabilisation of helical structures. RuCN/N-CDs either induce overexpression of the β-sheet-rich protein NDUFS1 and affect its random coil structure or interact and stabilise its structure via hydrogen bonding between -NH2 groups from N-CDs with protein C=O groups and –OH groups of serine, threonine, and tyrosine residues. The N-CD nanocarrier tunes this drug’s action by directing it toward a specific protein target, changing this drug’s coordination ability and inducing changes in the protein’s secondary structures and function.",
journal = "Pharmaceutics",
title = "Prediction of Protein Targets in Ovarian Cancer Using a Ru-Complex and Carbon Dot Drug Delivery Therapeutic Nanosystems: A Bioinformatics and μ-FTIR Spectroscopy Approach",
volume = "16",
number = "8",
pages = "997",
doi = "10.3390/pharmaceutics16080997"
}

Nešić, M. D., Dučić, T., Gemović, B., Senćanski, M., Algarra, M., Gonçalves, M., Stepić, M., Popović, I., Kapuran, Đ.,& Petković, M.. (2024). Prediction of Protein Targets in Ovarian Cancer Using a Ru-Complex and Carbon Dot Drug Delivery Therapeutic Nanosystems: A Bioinformatics and μ-FTIR Spectroscopy Approach. in Pharmaceutics, 16(8), 997.
https://doi.org/10.3390/pharmaceutics16080997

Nešić MD, Dučić T, Gemović B, Senćanski M, Algarra M, Gonçalves M, Stepić M, Popović I, Kapuran Đ, Petković M. Prediction of Protein Targets in Ovarian Cancer Using a Ru-Complex and Carbon Dot Drug Delivery Therapeutic Nanosystems: A Bioinformatics and μ-FTIR Spectroscopy Approach. in Pharmaceutics. 2024;16(8):997.
doi:10.3390/pharmaceutics16080997 .

Nešić, Maja D., Dučić, Tanja, Gemović, Branislava, Senćanski, Milan, Algarra, Manuel, Gonçalves, Mara, Stepić, Milutin, Popović, Iva, Kapuran, Đorđe, Petković, Marijana, "Prediction of Protein Targets in Ovarian Cancer Using a Ru-Complex and Carbon Dot Drug Delivery Therapeutic Nanosystems: A Bioinformatics and μ-FTIR Spectroscopy Approach" in Pharmaceutics, 16, no. 8 (2024):997,
https://doi.org/10.3390/pharmaceutics16080997 . .

TY  - CONF
AU  - Nešić, Maja D.
AU  - Popović, Iva
AU  - Algarra, Manuel
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Valenta Šobot, Ana
AU  - Filipović Tričković, Jelena
AU  - Stepić, Milutin
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13566
PB  - Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica
C3  - AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts
T1  - Synergistic effect of near infrared light and Ag-based metal-organic frameworks, loaded with sulphur or nitrogen carbon dots, on wound healing
SP  - 181
EP  - 181
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13566
ER  - 

@conference{
author = "Nešić, Maja D. and Popović, Iva and Algarra, Manuel and Korićanac, Lela and Žakula, Jelena and Valenta Šobot, Ana and Filipović Tričković, Jelena and Stepić, Milutin",
year = "2024",
publisher = "Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica",
journal = "AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts",
title = "Synergistic effect of near infrared light and Ag-based metal-organic frameworks, loaded with sulphur or nitrogen carbon dots, on wound healing",
pages = "181-181",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13566"
}

Nešić, M. D., Popović, I., Algarra, M., Korićanac, L., Žakula, J., Valenta Šobot, A., Filipović Tričković, J.,& Stepić, M.. (2024). Synergistic effect of near infrared light and Ag-based metal-organic frameworks, loaded with sulphur or nitrogen carbon dots, on wound healing. in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts
Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica., 181-181.
https://hdl.handle.net/21.15107/rcub_vinar_13566

Nešić MD, Popović I, Algarra M, Korićanac L, Žakula J, Valenta Šobot A, Filipović Tričković J, Stepić M. Synergistic effect of near infrared light and Ag-based metal-organic frameworks, loaded with sulphur or nitrogen carbon dots, on wound healing. in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts. 2024;:181-181.
https://hdl.handle.net/21.15107/rcub_vinar_13566 .

Nešić, Maja D., Popović, Iva, Algarra, Manuel, Korićanac, Lela, Žakula, Jelena, Valenta Šobot, Ana, Filipović Tričković, Jelena, Stepić, Milutin, "Synergistic effect of near infrared light and Ag-based metal-organic frameworks, loaded with sulphur or nitrogen carbon dots, on wound healing" in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts (2024):181-181,
https://hdl.handle.net/21.15107/rcub_vinar_13566 .

TY  - JOUR
AU  - Abu el Rub, Anamarija
AU  - Nešić, Maja D.
AU  - Dučić, Tanja
AU  - Radoičić, Marija
AU  - Novaković, Mirjana
AU  - Žakula, Jelena
AU  - Ralić, Vanja
AU  - Petković, Marijana
AU  - Stepić, Milutin
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13214
AB  - The increasing incidence rate of pancreatic cancer worldwide, along with high resistance to existing chemotherapies and radiotherapy, demand new approaches for its treatment. Nanoparticle-guided cancer treatment modalities are promising in their anti-cancer efficiency and upgrading potential. We have synthesized and characterized Gd-doped titanium-dioxide nanoparticles (Gd-TiO 2 NPs), which showed good biocompatibility with MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. To assess the effect that these NPs have on tumor cells, we used synchrotron radiation Fourier transform infrared spectroscopy and principal component analysis. We elucidated the biochemical changes in the two cell lines induced after their interaction with these NPs. Results demonstrated changes in nucleic acids and carbohydrate metabolism and alterations in the protein conformation in both cell lines. In addition, considerable changes in lipid area were observed in PANC-1 cell line, suggesting that Gd-TiO 2 NPs have a prospective to be further studied as systems for pancreatic cancer treatment.
T2  - Journal of Molecular Structure
T1  - Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles
VL  - 1309
SP  - 138167
DO  - 10.1016/j.molstruc.2024.138167
ER  - 

@article{
author = "Abu el Rub, Anamarija and Nešić, Maja D. and Dučić, Tanja and Radoičić, Marija and Novaković, Mirjana and Žakula, Jelena and Ralić, Vanja and Petković, Marijana and Stepić, Milutin",
year = "2024",
abstract = "The increasing incidence rate of pancreatic cancer worldwide, along with high resistance to existing chemotherapies and radiotherapy, demand new approaches for its treatment. Nanoparticle-guided cancer treatment modalities are promising in their anti-cancer efficiency and upgrading potential. We have synthesized and characterized Gd-doped titanium-dioxide nanoparticles (Gd-TiO 2 NPs), which showed good biocompatibility with MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. To assess the effect that these NPs have on tumor cells, we used synchrotron radiation Fourier transform infrared spectroscopy and principal component analysis. We elucidated the biochemical changes in the two cell lines induced after their interaction with these NPs. Results demonstrated changes in nucleic acids and carbohydrate metabolism and alterations in the protein conformation in both cell lines. In addition, considerable changes in lipid area were observed in PANC-1 cell line, suggesting that Gd-TiO 2 NPs have a prospective to be further studied as systems for pancreatic cancer treatment.",
journal = "Journal of Molecular Structure",
title = "Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles",
volume = "1309",
pages = "138167",
doi = "10.1016/j.molstruc.2024.138167"
}

Abu el Rub, A., Nešić, M. D., Dučić, T., Radoičić, M., Novaković, M., Žakula, J., Ralić, V., Petković, M.,& Stepić, M.. (2024). Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles. in Journal of Molecular Structure, 1309, 138167.
https://doi.org/10.1016/j.molstruc.2024.138167

Abu el Rub A, Nešić MD, Dučić T, Radoičić M, Novaković M, Žakula J, Ralić V, Petković M, Stepić M. Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles. in Journal of Molecular Structure. 2024;1309:138167.
doi:10.1016/j.molstruc.2024.138167 .

Abu el Rub, Anamarija, Nešić, Maja D., Dučić, Tanja, Radoičić, Marija, Novaković, Mirjana, Žakula, Jelena, Ralić, Vanja, Petković, Marijana, Stepić, Milutin, "Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles" in Journal of Molecular Structure, 1309 (2024):138167,
https://doi.org/10.1016/j.molstruc.2024.138167 . .

TY  - JOUR
AU  - Nešić, Maja D.
AU  - Popović, Iva A.
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Filipović Tričković, Jelena
AU  - Valenta Šobot, Ana
AU  - Jiménez, Maria Victoria
AU  - Algarra, Manuel
AU  - Dučić, Tanja
AU  - Stepić, Milutin
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13296
AB  - The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates the mechanisms of the synergistic wound healing potential of NIR light and silver metal–organic frameworks combined with nitrogen- and sulfur-doped carbon dots (AgMOFsN-CDs and AgMOFsS-CDs, respectively), which was conducted by testing the fibroblasts viability, scratch assays, biochemical analysis, and synchrotron-based Fourier transform infrared (SR-FTIR) cell spectroscopy and imaging. Our findings reveal that the combined treatment of AgMOFsN-CDs and NIR light significantly increases cell viability to nearly 150% and promotes cell proliferation, with reduced interleukin-1 levels, suggesting an anti-inflammatory response. SR-FTIR spectroscopy shows this combined treatment results in unique protein alterations, including increased α-helix structures and reduced cross-β. Additionally, protein synthesis was enhanced upon the combined treatment. The likely mechanism behind the observed changes is the charge-specific interaction of N-CDs from the AgMOFsN-CDs with proteins, enhanced by NIR light due to the nanocomposite’s optical characteristics. Remarkably, the complete wound closure in the in vitro scratch assay was achieved exclusively with the combined NIR and AgMOFsN-CDs treatment, demonstrating the promising application of combined AgMOFsN-CDs with NIR light photodynamic therapy in regenerative nanomedicine and tissue engineering.
T2  - Pharmaceutics
T1  - Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots
VL  - 16
IS  - 5
SP  - 671
DO  - 10.3390/pharmaceutics16050671
ER  - 

@article{
author = "Nešić, Maja D. and Popović, Iva A. and Žakula, Jelena and Korićanac, Lela and Filipović Tričković, Jelena and Valenta Šobot, Ana and Jiménez, Maria Victoria and Algarra, Manuel and Dučić, Tanja and Stepić, Milutin",
year = "2024",
abstract = "The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates the mechanisms of the synergistic wound healing potential of NIR light and silver metal–organic frameworks combined with nitrogen- and sulfur-doped carbon dots (AgMOFsN-CDs and AgMOFsS-CDs, respectively), which was conducted by testing the fibroblasts viability, scratch assays, biochemical analysis, and synchrotron-based Fourier transform infrared (SR-FTIR) cell spectroscopy and imaging. Our findings reveal that the combined treatment of AgMOFsN-CDs and NIR light significantly increases cell viability to nearly 150% and promotes cell proliferation, with reduced interleukin-1 levels, suggesting an anti-inflammatory response. SR-FTIR spectroscopy shows this combined treatment results in unique protein alterations, including increased α-helix structures and reduced cross-β. Additionally, protein synthesis was enhanced upon the combined treatment. The likely mechanism behind the observed changes is the charge-specific interaction of N-CDs from the AgMOFsN-CDs with proteins, enhanced by NIR light due to the nanocomposite’s optical characteristics. Remarkably, the complete wound closure in the in vitro scratch assay was achieved exclusively with the combined NIR and AgMOFsN-CDs treatment, demonstrating the promising application of combined AgMOFsN-CDs with NIR light photodynamic therapy in regenerative nanomedicine and tissue engineering.",
journal = "Pharmaceutics",
title = "Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots",
volume = "16",
number = "5",
pages = "671",
doi = "10.3390/pharmaceutics16050671"
}

Nešić, M. D., Popović, I. A., Žakula, J., Korićanac, L., Filipović Tričković, J., Valenta Šobot, A., Jiménez, M. V., Algarra, M., Dučić, T.,& Stepić, M.. (2024). Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots. in Pharmaceutics, 16(5), 671.
https://doi.org/10.3390/pharmaceutics16050671

Nešić MD, Popović IA, Žakula J, Korićanac L, Filipović Tričković J, Valenta Šobot A, Jiménez MV, Algarra M, Dučić T, Stepić M. Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots. in Pharmaceutics. 2024;16(5):671.
doi:10.3390/pharmaceutics16050671 .

Nešić, Maja D., Popović, Iva A., Žakula, Jelena, Korićanac, Lela, Filipović Tričković, Jelena, Valenta Šobot, Ana, Jiménez, Maria Victoria, Algarra, Manuel, Dučić, Tanja, Stepić, Milutin, "Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots" in Pharmaceutics, 16, no. 5 (2024):671,
https://doi.org/10.3390/pharmaceutics16050671 . .

TY  - CONF
AU  - Nešić, Maja D.
AU  - Popović, Iva
AU  - Ralić, Vanja
AU  - Dučić, Tanja
AU  - Algarra, M.
AU  - Stepić, Milutin
AU  - Petković, Marijana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13564
PB  - Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica
C3  - AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts
T1  - Synchrotron Radiation Fourier Transform Infrared spectroscopical analysis of biomolecules in MRC-5 fibroblast cells treated with biomass-derived carbon dots
SP  - 49
EP  - 49
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13564
ER  - 

@conference{
author = "Nešić, Maja D. and Popović, Iva and Ralić, Vanja and Dučić, Tanja and Algarra, M. and Stepić, Milutin and Petković, Marijana",
year = "2024",
publisher = "Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica",
journal = "AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts",
title = "Synchrotron Radiation Fourier Transform Infrared spectroscopical analysis of biomolecules in MRC-5 fibroblast cells treated with biomass-derived carbon dots",
pages = "49-49",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13564"
}

Nešić, M. D., Popović, I., Ralić, V., Dučić, T., Algarra, M., Stepić, M.,& Petković, M.. (2024). Synchrotron Radiation Fourier Transform Infrared spectroscopical analysis of biomolecules in MRC-5 fibroblast cells treated with biomass-derived carbon dots. in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts
Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica., 49-49.
https://hdl.handle.net/21.15107/rcub_vinar_13564

Nešić MD, Popović I, Ralić V, Dučić T, Algarra M, Stepić M, Petković M. Synchrotron Radiation Fourier Transform Infrared spectroscopical analysis of biomolecules in MRC-5 fibroblast cells treated with biomass-derived carbon dots. in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts. 2024;:49-49.
https://hdl.handle.net/21.15107/rcub_vinar_13564 .

Nešić, Maja D., Popović, Iva, Ralić, Vanja, Dučić, Tanja, Algarra, M., Stepić, Milutin, Petković, Marijana, "Synchrotron Radiation Fourier Transform Infrared spectroscopical analysis of biomolecules in MRC-5 fibroblast cells treated with biomass-derived carbon dots" in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts (2024):49-49,
https://hdl.handle.net/21.15107/rcub_vinar_13564 .

TY  - CONF
AU  - Matijević, Milica
AU  - Nešić, Maja D.
AU  - Estrela-Lopis, Irina
AU  - Petković, Marijana
AU  - Stepić, Milutin
AU  - Popović, Iva
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13565
PB  - Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica
C3  - AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts
T1  - Ultrafast laser-assisted production of nano-and micro-plastics and their interaction with cells
SP  - 168
EP  - 168
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13565
ER  - 

@conference{
author = "Matijević, Milica and Nešić, Maja D. and Estrela-Lopis, Irina and Petković, Marijana and Stepić, Milutin and Popović, Iva",
year = "2024",
publisher = "Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica",
journal = "AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts",
title = "Ultrafast laser-assisted production of nano-and micro-plastics and their interaction with cells",
pages = "168-168",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13565"
}

Matijević, M., Nešić, M. D., Estrela-Lopis, I., Petković, M., Stepić, M.,& Popović, I.. (2024). Ultrafast laser-assisted production of nano-and micro-plastics and their interaction with cells. in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts
Portugal : SPOF - Sociedade Portuguesa para a Investigação e Desenvolvimento em Óptica e Fotónica., 168-168.
https://hdl.handle.net/21.15107/rcub_vinar_13565

Matijević M, Nešić MD, Estrela-Lopis I, Petković M, Stepić M, Popović I. Ultrafast laser-assisted production of nano-and micro-plastics and their interaction with cells. in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts. 2024;:168-168.
https://hdl.handle.net/21.15107/rcub_vinar_13565 .

Matijević, Milica, Nešić, Maja D., Estrela-Lopis, Irina, Petković, Marijana, Stepić, Milutin, Popović, Iva, "Ultrafast laser-assisted production of nano-and micro-plastics and their interaction with cells" in AOP 24 : 6th International Conference on Applications of Optics and Photonics : Book of abstracts (2024):168-168,
https://hdl.handle.net/21.15107/rcub_vinar_13565 .

TY  - CONF
AU  - Popović, Iva
AU  - Nišavić, Marija
AU  - Ralić, Vanja
AU  - Petković, Marijana
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Stepić, Milutin
AU  - Nešić, Maja D.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13567
AB  - Chemotherapy is one of the most effective approaches used to treat cancer, a leading
cause of death worldwide.[1] Ruthenium-based complexes have emerged as a powerful
alternative to state-of-the-art platinum chemotherapeutics due to their reduced toxicity,
higher selectivity and anti-metastatic potential.[2] Here, we employ mass spectrometry and
spectroscopic techniques to characterize a novel cis-[Ru(II)(dcbpy)2Cl2] complex and
investigate its interaction with cellular lipids. In addition, the cytotoxic effect and mode of
action on four standard cancer cell lines, namely melanoma A375, cervical cancer HeLa and
pancreas ductal adenocarcinoma MIA PaCa-2 and PANC-1, were elucidated. Our results
show a dose-dependent cytotoxicity of the complex on A375, MIA PaCa-2 and PANC-1.
Further, the Ru(II) complex reduces the clonogenic potential caused by G1 arrest and
increases ROS production in all tested cell lines. Lipid peroxidation is also observed in
HeLa and MIA PaCa-2 cells, possibly indicating ferroptosis induction. Synchrotron
radiation Fourier Transform Infrared Spectroscopy was applied to study the overall
interaction of a Ru-complex with cellular biomolecules, and our results demonstrated a shift
in bands in the lipid fingerprint area of most cell lines, confirming the lipid rearrangement
process induced by the interaction with Ru(II) complex. The complex significantly
increases the percentage of apoptotic A375, HeLa and MIA PaCa-2, while a significant
decrease of p62 protein, a marker for autophagy induction, is detected solely in A375 cells.
The wound healing assay revealed that the Ru(II) complex reduces the metastatic potential
of HeLa and MIA PaCa-2 cells by reducing their migration ability. Overall, our results
indicate the existence of a general mode of action of the tested Ru(II) complex that involves
growth arrest and ROS production, as well as cancer cell line-specific effects. These involve
dual role trough inducing programmed cell death - apoptosis and autophagy as seen in A375
cells, or apoptosis and ferroptosis as indicated by the results obtained on HeLa and MIA
PaCa-2 cells, where anti-metastatic potential was also observed. This work highlights the
multimodal action of Ru(II) complexes and the broadness of their application as potential
chemotherapeutic agents for treating different cancers.[3]
C3  - ICNI-III : 3rd International Conference on Noncovalent Interactions : Book of abstracts
T1  - The interaction of a novel Ru(II) complex with cellular lipids and induction of programed cell death in cancer cell lines
SP  - P12
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13567
ER  - 

@conference{
author = "Popović, Iva and Nišavić, Marija and Ralić, Vanja and Petković, Marijana and Žakula, Jelena and Korićanac, Lela and Stepić, Milutin and Nešić, Maja D.",
year = "2024",
abstract = "Chemotherapy is one of the most effective approaches used to treat cancer, a leading
cause of death worldwide.[1] Ruthenium-based complexes have emerged as a powerful
alternative to state-of-the-art platinum chemotherapeutics due to their reduced toxicity,
higher selectivity and anti-metastatic potential.[2] Here, we employ mass spectrometry and
spectroscopic techniques to characterize a novel cis-[Ru(II)(dcbpy)2Cl2] complex and
investigate its interaction with cellular lipids. In addition, the cytotoxic effect and mode of
action on four standard cancer cell lines, namely melanoma A375, cervical cancer HeLa and
pancreas ductal adenocarcinoma MIA PaCa-2 and PANC-1, were elucidated. Our results
show a dose-dependent cytotoxicity of the complex on A375, MIA PaCa-2 and PANC-1.
Further, the Ru(II) complex reduces the clonogenic potential caused by G1 arrest and
increases ROS production in all tested cell lines. Lipid peroxidation is also observed in
HeLa and MIA PaCa-2 cells, possibly indicating ferroptosis induction. Synchrotron
radiation Fourier Transform Infrared Spectroscopy was applied to study the overall
interaction of a Ru-complex with cellular biomolecules, and our results demonstrated a shift
in bands in the lipid fingerprint area of most cell lines, confirming the lipid rearrangement
process induced by the interaction with Ru(II) complex. The complex significantly
increases the percentage of apoptotic A375, HeLa and MIA PaCa-2, while a significant
decrease of p62 protein, a marker for autophagy induction, is detected solely in A375 cells.
The wound healing assay revealed that the Ru(II) complex reduces the metastatic potential
of HeLa and MIA PaCa-2 cells by reducing their migration ability. Overall, our results
indicate the existence of a general mode of action of the tested Ru(II) complex that involves
growth arrest and ROS production, as well as cancer cell line-specific effects. These involve
dual role trough inducing programmed cell death - apoptosis and autophagy as seen in A375
cells, or apoptosis and ferroptosis as indicated by the results obtained on HeLa and MIA
PaCa-2 cells, where anti-metastatic potential was also observed. This work highlights the
multimodal action of Ru(II) complexes and the broadness of their application as potential
chemotherapeutic agents for treating different cancers.[3]",
journal = "ICNI-III : 3rd International Conference on Noncovalent Interactions : Book of abstracts",
title = "The interaction of a novel Ru(II) complex with cellular lipids and induction of programed cell death in cancer cell lines",
pages = "P12",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13567"
}

Popović, I., Nišavić, M., Ralić, V., Petković, M., Žakula, J., Korićanac, L., Stepić, M.,& Nešić, M. D.. (2024). The interaction of a novel Ru(II) complex with cellular lipids and induction of programed cell death in cancer cell lines. in ICNI-III : 3rd International Conference on Noncovalent Interactions : Book of abstracts, P12.
https://hdl.handle.net/21.15107/rcub_vinar_13567

Popović I, Nišavić M, Ralić V, Petković M, Žakula J, Korićanac L, Stepić M, Nešić MD. The interaction of a novel Ru(II) complex with cellular lipids and induction of programed cell death in cancer cell lines. in ICNI-III : 3rd International Conference on Noncovalent Interactions : Book of abstracts. 2024;:P12.
https://hdl.handle.net/21.15107/rcub_vinar_13567 .

Popović, Iva, Nišavić, Marija, Ralić, Vanja, Petković, Marijana, Žakula, Jelena, Korićanac, Lela, Stepić, Milutin, Nešić, Maja D., "The interaction of a novel Ru(II) complex with cellular lipids and induction of programed cell death in cancer cell lines" in ICNI-III : 3rd International Conference on Noncovalent Interactions : Book of abstracts (2024):P12,
https://hdl.handle.net/21.15107/rcub_vinar_13567 .

TY  - CONF
AU  - Popović, Iva
AU  - Valenta Šobot, Ana
AU  - Filipović Tričković, Jelena
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Ralić, Vanja
AU  - Abu el Rub, Anamarija
AU  - Algarra, Manuel
AU  - Petković, Marijana
AU  - Stepić, Milutin
AU  - Nešić, Maja D.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11808
AB  - In recent years researchers have developed new strategies to enhance the effectiveness of wound healing by combining nanoparticles and infra red (IR) light. For example, some studies have shown that nanoparticles can be used to enhance the absorption of near-infrared laser (NIR) light by tissues, leading to increased healing rates [1]. The influence of NIR light on proliferation, collagen production, and wound healing was tested on: keratocytes (HaCaT) and fibroblasts (MRC-5) cells that are used as model systems of human skin equivalents that comprise an epidermal and a dermal compartment of skin. Also, these cells were treated with carbon quantum dots/silver-based metal-organic framework composites (Ag-MoFs-NCDs and Ag-MoFs-SCDs), which previously showed high antibacterial activity [2], without and with laser light. Firstly, we have found the most convenient and effective CW laser intensity (16 mW/cm2) and illumination time (3 minutes), which is not too high and short enough to influence human cells' proliferation and metabolism positively. Additional chemical treatment with Ag-MoFs-NCDs and Ag-MoFs-SCDs results in a further increase in human cell viability. Our measurements showed that the proliferation index in laser-illuminated cells and cells treated with Ag-MoFs-SCDs was at the level of the untreated control. Furthermore, Ag-MoFs-SCDs treatment and laser illumination induced a mild, insignificant increase in cellular proliferation. On the other hand, Ag-MoFs-NCDs treatment led to a more pronounced, albeit not significant increase, in cellular proliferation, while Ag-MoFs-NCDs treatment combined with laser illumination significantly increased proliferation. Also, we have detected a mild change in collagen level estimated by hydroxyproline assay, which may indicate a positive outcome of combined laser illumination and treatment, taking into account that after 48 hours, a change in cell's response to the treatment could be noticed. Finally, based on migration assay, we observe a complete wound closure after 48 hours in fibroblast cells treated with Ag-MoFs-NCDs and near-infrared laser light, Fig. 1.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts
T1  - Carbon quantum dots/silver based metal organic framework composites in light enhanced wound healing
SP  - 78
EP  - 78
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11808
ER  - 

@conference{
author = "Popović, Iva and Valenta Šobot, Ana and Filipović Tričković, Jelena and Korićanac, Lela and Žakula, Jelena and Ralić, Vanja and Abu el Rub, Anamarija and Algarra, Manuel and Petković, Marijana and Stepić, Milutin and Nešić, Maja D.",
year = "2023",
abstract = "In recent years researchers have developed new strategies to enhance the effectiveness of wound healing by combining nanoparticles and infra red (IR) light. For example, some studies have shown that nanoparticles can be used to enhance the absorption of near-infrared laser (NIR) light by tissues, leading to increased healing rates [1]. The influence of NIR light on proliferation, collagen production, and wound healing was tested on: keratocytes (HaCaT) and fibroblasts (MRC-5) cells that are used as model systems of human skin equivalents that comprise an epidermal and a dermal compartment of skin. Also, these cells were treated with carbon quantum dots/silver-based metal-organic framework composites (Ag-MoFs-NCDs and Ag-MoFs-SCDs), which previously showed high antibacterial activity [2], without and with laser light. Firstly, we have found the most convenient and effective CW laser intensity (16 mW/cm2) and illumination time (3 minutes), which is not too high and short enough to influence human cells' proliferation and metabolism positively. Additional chemical treatment with Ag-MoFs-NCDs and Ag-MoFs-SCDs results in a further increase in human cell viability. Our measurements showed that the proliferation index in laser-illuminated cells and cells treated with Ag-MoFs-SCDs was at the level of the untreated control. Furthermore, Ag-MoFs-SCDs treatment and laser illumination induced a mild, insignificant increase in cellular proliferation. On the other hand, Ag-MoFs-NCDs treatment led to a more pronounced, albeit not significant increase, in cellular proliferation, while Ag-MoFs-NCDs treatment combined with laser illumination significantly increased proliferation. Also, we have detected a mild change in collagen level estimated by hydroxyproline assay, which may indicate a positive outcome of combined laser illumination and treatment, taking into account that after 48 hours, a change in cell's response to the treatment could be noticed. Finally, based on migration assay, we observe a complete wound closure after 48 hours in fibroblast cells treated with Ag-MoFs-NCDs and near-infrared laser light, Fig. 1.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts",
title = "Carbon quantum dots/silver based metal organic framework composites in light enhanced wound healing",
pages = "78-78",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11808"
}

Popović, I., Valenta Šobot, A., Filipović Tričković, J., Korićanac, L., Žakula, J., Ralić, V., Abu el Rub, A., Algarra, M., Petković, M., Stepić, M.,& Nešić, M. D.. (2023). Carbon quantum dots/silver based metal organic framework composites in light enhanced wound healing. in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts
Belgrade : Vinča Institute of Nuclear Sciences., 78-78.
https://hdl.handle.net/21.15107/rcub_vinar_11808

Popović I, Valenta Šobot A, Filipović Tričković J, Korićanac L, Žakula J, Ralić V, Abu el Rub A, Algarra M, Petković M, Stepić M, Nešić MD. Carbon quantum dots/silver based metal organic framework composites in light enhanced wound healing. in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts. 2023;:78-78.
https://hdl.handle.net/21.15107/rcub_vinar_11808 .

Popović, Iva, Valenta Šobot, Ana, Filipović Tričković, Jelena, Korićanac, Lela, Žakula, Jelena, Ralić, Vanja, Abu el Rub, Anamarija, Algarra, Manuel, Petković, Marijana, Stepić, Milutin, Nešić, Maja D., "Carbon quantum dots/silver based metal organic framework composites in light enhanced wound healing" in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts (2023):78-78,
https://hdl.handle.net/21.15107/rcub_vinar_11808 .

TY  - CONF
AU  - Ralić, Vanja
AU  - Gemović, Branislava
AU  - Nešić, Maja D.
AU  - Popović, Iva
AU  - Stepić, Milutin
AU  - Petković, Marijana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12390
AB  - In this work, we have applied the Informational Spectrum Method (ISM) to discover a potential protein target in the HeLa cervical cancer cell line for [Pd(dach)Cl2] complex. Since Pd complexes are considered an alternative to traditionally used Pt complexes in anti-cancer therapy, it is essential to elucidate the mechanism of their action. A detailed analysis that also involves screening the known protein databases revealed the proteins of the SOSS complex as the most probable [Pd(dach)Cl2] targets. Since this protein maintains genomic stability, this result shows the potential of the Pd(II) complex as an anti-cancer drug.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - Identification of protein target molecules for [Pd(dach)Cl2] complex in HeLa cervical carcinoma cells
SP  - 296
EP  - 299
DO  - 10.46793/ICCBI23.296R
ER  - 

@conference{
author = "Ralić, Vanja and Gemović, Branislava and Nešić, Maja D. and Popović, Iva and Stepić, Milutin and Petković, Marijana",
year = "2023",
abstract = "In this work, we have applied the Informational Spectrum Method (ISM) to discover a potential protein target in the HeLa cervical cancer cell line for [Pd(dach)Cl2] complex. Since Pd complexes are considered an alternative to traditionally used Pt complexes in anti-cancer therapy, it is essential to elucidate the mechanism of their action. A detailed analysis that also involves screening the known protein databases revealed the proteins of the SOSS complex as the most probable [Pd(dach)Cl2] targets. Since this protein maintains genomic stability, this result shows the potential of the Pd(II) complex as an anti-cancer drug.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "Identification of protein target molecules for [Pd(dach)Cl2] complex in HeLa cervical carcinoma cells",
pages = "296-299",
doi = "10.46793/ICCBI23.296R"
}

Ralić, V., Gemović, B., Nešić, M. D., Popović, I., Stepić, M.,& Petković, M.. (2023). Identification of protein target molecules for [Pd(dach)Cl2] complex in HeLa cervical carcinoma cells. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 296-299.
https://doi.org/10.46793/ICCBI23.296R

Ralić V, Gemović B, Nešić MD, Popović I, Stepić M, Petković M. Identification of protein target molecules for [Pd(dach)Cl2] complex in HeLa cervical carcinoma cells. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:296-299.
doi:10.46793/ICCBI23.296R .

Ralić, Vanja, Gemović, Branislava, Nešić, Maja D., Popović, Iva, Stepić, Milutin, Petković, Marijana, "Identification of protein target molecules for [Pd(dach)Cl2] complex in HeLa cervical carcinoma cells" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):296-299,
https://doi.org/10.46793/ICCBI23.296R . .

TY  - CONF
AU  - Petković, Marijana
AU  - Stepić, Milutin
AU  - Popović, Iva
AU  - Algarra, Manuel
AU  - Dučić, Tanja
AU  - Abu el Rub, Anamarija
AU  - Ralić, Vanja
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Filipović Tričković, Jelena
AU  - Valenta Šobot, Ana
AU  - Nešić, Maja D.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13568
AB  - Small, carbon-based nanoparticles, carbon dots (CDs), are investigated as photosensitizers (PSs) for photodynamic therapy of cancers. The results presented here show biochemical changes in cancer cells treated with surface-modified CDs, which are augmented by illumination, indicating a high potential of CDs as selective drug carriers and potent PSs. In addition, we will show that CDs produced from black carrot extract (biomass) can be exploited for image-guided therapy and be cytotoxic for cancer cells, thanks to their fluorescence properties. Finally, since biomass-fabricated CDs interact strongly with nucleic acids, they can be further developed for cell cycle sensing purposes.
PB  - Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - Application of Carbon-Based Nanocomposite Systems as Photosensitizers for Photodynamic Therapy
SP  - 61
EP  - 66
DO  - 10.46793/ICCBI23.061P
ER  - 

@conference{
author = "Petković, Marijana and Stepić, Milutin and Popović, Iva and Algarra, Manuel and Dučić, Tanja and Abu el Rub, Anamarija and Ralić, Vanja and Korićanac, Lela and Žakula, Jelena and Filipović Tričković, Jelena and Valenta Šobot, Ana and Nešić, Maja D.",
year = "2023",
abstract = "Small, carbon-based nanoparticles, carbon dots (CDs), are investigated as photosensitizers (PSs) for photodynamic therapy of cancers. The results presented here show biochemical changes in cancer cells treated with surface-modified CDs, which are augmented by illumination, indicating a high potential of CDs as selective drug carriers and potent PSs. In addition, we will show that CDs produced from black carrot extract (biomass) can be exploited for image-guided therapy and be cytotoxic for cancer cells, thanks to their fluorescence properties. Finally, since biomass-fabricated CDs interact strongly with nucleic acids, they can be further developed for cell cycle sensing purposes.",
publisher = "Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "Application of Carbon-Based Nanocomposite Systems as Photosensitizers for Photodynamic Therapy",
pages = "61-66",
doi = "10.46793/ICCBI23.061P"
}

Petković, M., Stepić, M., Popović, I., Algarra, M., Dučić, T., Abu el Rub, A., Ralić, V., Korićanac, L., Žakula, J., Filipović Tričković, J., Valenta Šobot, A.,& Nešić, M. D.. (2023). Application of Carbon-Based Nanocomposite Systems as Photosensitizers for Photodynamic Therapy. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Institute for Information Technologies, University of Kragujevac., 61-66.
https://doi.org/10.46793/ICCBI23.061P

Petković M, Stepić M, Popović I, Algarra M, Dučić T, Abu el Rub A, Ralić V, Korićanac L, Žakula J, Filipović Tričković J, Valenta Šobot A, Nešić MD. Application of Carbon-Based Nanocomposite Systems as Photosensitizers for Photodynamic Therapy. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:61-66.
doi:10.46793/ICCBI23.061P .

Petković, Marijana, Stepić, Milutin, Popović, Iva, Algarra, Manuel, Dučić, Tanja, Abu el Rub, Anamarija, Ralić, Vanja, Korićanac, Lela, Žakula, Jelena, Filipović Tričković, Jelena, Valenta Šobot, Ana, Nešić, Maja D., "Application of Carbon-Based Nanocomposite Systems as Photosensitizers for Photodynamic Therapy" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):61-66,
https://doi.org/10.46793/ICCBI23.061P . .

TY  - CONF
AU  - Nešić, M. D.
AU  - Filipović Tričković, Jelena
AU  - Valenta Šobot, Ana
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Popović, Iva
AU  - Soto, J.
AU  - Algarra, Manuel
AU  - Ralić, Vanja
AU  - Abu el Rub, Anamarija
AU  - Matijević, Milica
AU  - Stepić, Milutin
AU  - Petković, M.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11809
AB  - Carbon Dots (CDs) are biocompatible, fluorescent, water-soluble, and stable nanoparticles with a high potential to be used for vast biomedical applications [1,2]. We explore the application of CDs produced from natural sources, black carrots, as anti-cancer and imaging agents. These nanoparticles suppress cell growth of three different cancer cell lines, cervical (HeLa), pancreatic (PANC-1), and melanoma (A375) cell lines in vitro. However, the cytotoxic effect against A375 cells stands out, with only 20% of viable cells left after treatment (Fig.1(a)), antimetastatic potential, and a selectivity index higher than two, which indicates that the efficacy against melanoma cells is significantly greater than the toxicity against non-malignant cells (MRC-5). Furthermore, after the cellular uptake, green fluorescence was visible in the cytosol of A375 cells (Fig. 1 (b)). On the other hand, the DAPI stain for DNA was visible as a blue light in the cell nucleus. Moreover, cells with a higher intensity of green fluorescence in the nucleus, Fig. 1 (c) indicated with arrows, were the cells with condensed chromatin in the mitotic phase of the cell cycle (Fig. 1 (d) and (e)), which indicates that CDs interact with chromatin and that they could be used as a marker of cells mitosis and proliferation. In summary, we have demonstrated the great anti-cancer potential of black carrot CDs, for image-guided anti-cancer therapy of melanoma that can be used to recognize cell proliferation.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts
T1  - Anti-cancer and imaging potential of fluorescent black carrot Carbon Dot nanoparticles
SP  - 79
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11809
ER  - 

@conference{
author = "Nešić, M. D. and Filipović Tričković, Jelena and Valenta Šobot, Ana and Žakula, Jelena and Korićanac, Lela and Popović, Iva and Soto, J. and Algarra, Manuel and Ralić, Vanja and Abu el Rub, Anamarija and Matijević, Milica and Stepić, Milutin and Petković, M.",
year = "2023",
abstract = "Carbon Dots (CDs) are biocompatible, fluorescent, water-soluble, and stable nanoparticles with a high potential to be used for vast biomedical applications [1,2]. We explore the application of CDs produced from natural sources, black carrots, as anti-cancer and imaging agents. These nanoparticles suppress cell growth of three different cancer cell lines, cervical (HeLa), pancreatic (PANC-1), and melanoma (A375) cell lines in vitro. However, the cytotoxic effect against A375 cells stands out, with only 20% of viable cells left after treatment (Fig.1(a)), antimetastatic potential, and a selectivity index higher than two, which indicates that the efficacy against melanoma cells is significantly greater than the toxicity against non-malignant cells (MRC-5). Furthermore, after the cellular uptake, green fluorescence was visible in the cytosol of A375 cells (Fig. 1 (b)). On the other hand, the DAPI stain for DNA was visible as a blue light in the cell nucleus. Moreover, cells with a higher intensity of green fluorescence in the nucleus, Fig. 1 (c) indicated with arrows, were the cells with condensed chromatin in the mitotic phase of the cell cycle (Fig. 1 (d) and (e)), which indicates that CDs interact with chromatin and that they could be used as a marker of cells mitosis and proliferation. In summary, we have demonstrated the great anti-cancer potential of black carrot CDs, for image-guided anti-cancer therapy of melanoma that can be used to recognize cell proliferation.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts",
title = "Anti-cancer and imaging potential of fluorescent black carrot Carbon Dot nanoparticles",
pages = "79-79",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11809"
}

Nešić, M. D., Filipović Tričković, J., Valenta Šobot, A., Žakula, J., Korićanac, L., Popović, I., Soto, J., Algarra, M., Ralić, V., Abu el Rub, A., Matijević, M., Stepić, M.,& Petković, M.. (2023). Anti-cancer and imaging potential of fluorescent black carrot Carbon Dot nanoparticles. in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts
Belgrade : Vinča Institute of Nuclear Sciences., 79-79.
https://hdl.handle.net/21.15107/rcub_vinar_11809

Nešić MD, Filipović Tričković J, Valenta Šobot A, Žakula J, Korićanac L, Popović I, Soto J, Algarra M, Ralić V, Abu el Rub A, Matijević M, Stepić M, Petković M. Anti-cancer and imaging potential of fluorescent black carrot Carbon Dot nanoparticles. in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts. 2023;:79-79.
https://hdl.handle.net/21.15107/rcub_vinar_11809 .

Nešić, M. D., Filipović Tričković, Jelena, Valenta Šobot, Ana, Žakula, Jelena, Korićanac, Lela, Popović, Iva, Soto, J., Algarra, Manuel, Ralić, Vanja, Abu el Rub, Anamarija, Matijević, Milica, Stepić, Milutin, Petković, M., "Anti-cancer and imaging potential of fluorescent black carrot Carbon Dot nanoparticles" in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts (2023):79-79,
https://hdl.handle.net/21.15107/rcub_vinar_11809 .

TY  - CONF
AU  - Abu el Rub, Anamarija
AU  - Nešić, M. D.
AU  - Žakula, Jelena
AU  - Ralić, Vanja
AU  - Petković, M.
AU  - Popović, Iva
AU  - Matijević, Milica
AU  - Radoičić, Marija
AU  - Stepić, Milutin
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11810
AB  - With difficulty in early diagnosis, inaccessibility for the surgical approach, and high resistance to radio and chemotherapies, the resulting low treatment success rates are calling for new approaches in treating pancreatic cancer [1]. Photodynamic therapy (PDT), with the use of light or X-rays, is a method that has the potential to help overcome the problems that existing approaches meet [2,3]. Through activation of photo-sensitive particles with irradiation, PDT helps the production of reactive oxygen species, consequently stimulating cell death. We have synthesized and characterized Gadolinium-doped titanium dioxide nanoparticles (Gd-TiO2 NPs) and tested them as photosensitizers on two pancreatic cancer cell lines, MIA PaCa-2 and PANC-1. Different concentrations of NP treatment, irradiation powers, and times of irradiation were trialed as parameters of activation. Cell viability was measured 48h after treatments, and although some results implied a slight decrease in the viability of treated cells, we have met difficulties in obtaining consistency in results. Statistical significance in the decrease of the viability of treated cells in most cases was not attained, suggesting that higher concentrations or irradiation power and longer illumination time might be needed to achieve a positive PDT effect with this NP system.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts
T1  - In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells
SP  - 80
EP  - 80
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11810
ER  - 

@conference{
author = "Abu el Rub, Anamarija and Nešić, M. D. and Žakula, Jelena and Ralić, Vanja and Petković, M. and Popović, Iva and Matijević, Milica and Radoičić, Marija and Stepić, Milutin",
year = "2023",
abstract = "With difficulty in early diagnosis, inaccessibility for the surgical approach, and high resistance to radio and chemotherapies, the resulting low treatment success rates are calling for new approaches in treating pancreatic cancer [1]. Photodynamic therapy (PDT), with the use of light or X-rays, is a method that has the potential to help overcome the problems that existing approaches meet [2,3]. Through activation of photo-sensitive particles with irradiation, PDT helps the production of reactive oxygen species, consequently stimulating cell death. We have synthesized and characterized Gadolinium-doped titanium dioxide nanoparticles (Gd-TiO2 NPs) and tested them as photosensitizers on two pancreatic cancer cell lines, MIA PaCa-2 and PANC-1. Different concentrations of NP treatment, irradiation powers, and times of irradiation were trialed as parameters of activation. Cell viability was measured 48h after treatments, and although some results implied a slight decrease in the viability of treated cells, we have met difficulties in obtaining consistency in results. Statistical significance in the decrease of the viability of treated cells in most cases was not attained, suggesting that higher concentrations or irradiation power and longer illumination time might be needed to achieve a positive PDT effect with this NP system.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts",
title = "In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells",
pages = "80-80",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11810"
}

Abu el Rub, A., Nešić, M. D., Žakula, J., Ralić, V., Petković, M., Popović, I., Matijević, M., Radoičić, M.,& Stepić, M.. (2023). In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells. in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts
Belgrade : Vinča Institute of Nuclear Sciences., 80-80.
https://hdl.handle.net/21.15107/rcub_vinar_11810

Abu el Rub A, Nešić MD, Žakula J, Ralić V, Petković M, Popović I, Matijević M, Radoičić M, Stepić M. In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells. in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts. 2023;:80-80.
https://hdl.handle.net/21.15107/rcub_vinar_11810 .

Abu el Rub, Anamarija, Nešić, M. D., Žakula, Jelena, Ralić, Vanja, Petković, M., Popović, Iva, Matijević, Milica, Radoičić, Marija, Stepić, Milutin, "In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells" in PHOTONICA2023 : 9th International School and Conference on Photonics : Book of abstracts (2023):80-80,
https://hdl.handle.net/21.15107/rcub_vinar_11810 .

TY  - CONF
AU  - Ralić, Vanja
AU  - Nešić, Maja
AU  - Abu el Rub, Anamarija
AU  - Dučić, Tanja
AU  - Gemović, Branislava
AU  - Algarra, Manuel
AU  - Stepić, Milutin
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Petković, Marijana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12657
AB  - Nanocomposite system formulated from surface-modified S-doped carbon dot (S-CD) nanoparticle with a potential metallodrug, palladium(II) complex, dichloro(1,2-diaminocyclohexane)palladium(II), [Pd(dach)Cl2] (Pd@S-CD), was investigated as a model system for the treatment of cervical carcinoma (HeLa) cells. To examine the intracellular biochemical effects induced by the Pd@S-CD, we used Synchrotron Radiation-based Fourier-transform infrared spectroscopy (SR FTIR). SR FTIR spectroscopy was employed to investigate the alterations in cellular components’ biochemical composition and secondary structure upon exposure to Pd@S-CD. Spectral analysis, complemented by statistical techniques, revealed changes in biomolecules, lipids, proteins, nucleic acids, and carbohydrates caused by the treatment with Pd@CDs. These results and the increased cytotoxicity of the system demonstrate its high anti-cervical cancer therapeutic potential.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - SR FTIR spectroscopy investigation of Pd@S-CD nanocomposite system effects on biomolecules in cervical carcinoma cells
SP  - 467
EP  - 470
DO  - 10.46793/ICCBI23.467R
ER  - 

@conference{
author = "Ralić, Vanja and Nešić, Maja and Abu el Rub, Anamarija and Dučić, Tanja and Gemović, Branislava and Algarra, Manuel and Stepić, Milutin and Korićanac, Lela and Žakula, Jelena and Petković, Marijana",
year = "2023",
abstract = "Nanocomposite system formulated from surface-modified S-doped carbon dot (S-CD) nanoparticle with a potential metallodrug, palladium(II) complex, dichloro(1,2-diaminocyclohexane)palladium(II), [Pd(dach)Cl2] (Pd@S-CD), was investigated as a model system for the treatment of cervical carcinoma (HeLa) cells. To examine the intracellular biochemical effects induced by the Pd@S-CD, we used Synchrotron Radiation-based Fourier-transform infrared spectroscopy (SR FTIR). SR FTIR spectroscopy was employed to investigate the alterations in cellular components’ biochemical composition and secondary structure upon exposure to Pd@S-CD. Spectral analysis, complemented by statistical techniques, revealed changes in biomolecules, lipids, proteins, nucleic acids, and carbohydrates caused by the treatment with Pd@CDs. These results and the increased cytotoxicity of the system demonstrate its high anti-cervical cancer therapeutic potential.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "SR FTIR spectroscopy investigation of Pd@S-CD nanocomposite system effects on biomolecules in cervical carcinoma cells",
pages = "467-470",
doi = "10.46793/ICCBI23.467R"
}

Ralić, V., Nešić, M., Abu el Rub, A., Dučić, T., Gemović, B., Algarra, M., Stepić, M., Korićanac, L., Žakula, J.,& Petković, M.. (2023). SR FTIR spectroscopy investigation of Pd@S-CD nanocomposite system effects on biomolecules in cervical carcinoma cells. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 467-470.
https://doi.org/10.46793/ICCBI23.467R

Ralić V, Nešić M, Abu el Rub A, Dučić T, Gemović B, Algarra M, Stepić M, Korićanac L, Žakula J, Petković M. SR FTIR spectroscopy investigation of Pd@S-CD nanocomposite system effects on biomolecules in cervical carcinoma cells. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:467-470.
doi:10.46793/ICCBI23.467R .

Ralić, Vanja, Nešić, Maja, Abu el Rub, Anamarija, Dučić, Tanja, Gemović, Branislava, Algarra, Manuel, Stepić, Milutin, Korićanac, Lela, Žakula, Jelena, Petković, Marijana, "SR FTIR spectroscopy investigation of Pd@S-CD nanocomposite system effects on biomolecules in cervical carcinoma cells" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):467-470,
https://doi.org/10.46793/ICCBI23.467R . .

TY  - CONF
AU  - Stojanović, Mirjana G.
AU  - Maluckov, Aleksandra
AU  - Stepić, Milutin
AU  - Mančić, Ana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11852
AB  - Flat-band (FB) photonic lattices have been in the focus of researchers since they represent an excellent
platform for studying various fundamental physical phenomena difficult to achieve in the condensed
matter systems. Working with photonic lattices is very comfortable because they are easy to manipulate with
and it is possible to directly observe the wave dynamics. An important property of FBs lattice is that they can
host a complete set of compact localized modes (CLMs), highly robust to environmental noise. Due to lattice
their geometry, it is possible to design artificial gauge field effects which are equivalent to the magnetic field
flux, i. e. the spin-orbit interaction in atomic systems.
We have studied a two-dimensional (2D) linear and nonlinearphotonic lattices dressed by the artificial flux and
have explored the influence of the artificial gauge field on the energy band spectrum. We investigated CLM
in three types of 2D photonic lattices: octagonal-diamond, dice and plus-like lattice. Each of these lattices is
characterized by the presence of diamond plaquettes in the structure. When diamond plaquettes are dressed by
artificial flux, the Aharonov-Bohm effect has caused the appearance of new FBs for certain values of the flux.
The dynamics of the CLMs in the mentioned flux-dressed lattices have been analyzed numerically, using
the Runge-Kutta procedure of the 6th order. To describe the dynamic properties of CLMs, in the presence
of nonlinearity and artificial flux, we calculated some of the following quantities: the participation number,
which is a measure of the mode localization; the mode overlapping, which represents normalized magnitude
of the field overlap; and total intensity distribution. The evolution of these quantities show the efficiency of the
mode compactness andlocalization.
C3  - WCLOP2023 : 5th World Congress on Lasers, Optics and Photonics : Book of abstracts
T1  - Playing with the artificial flux in diamond plaquettes in different photonic lattices
SP  - 65
EP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11852
ER  - 

@conference{
author = "Stojanović, Mirjana G. and Maluckov, Aleksandra and Stepić, Milutin and Mančić, Ana",
year = "2023",
abstract = "Flat-band (FB) photonic lattices have been in the focus of researchers since they represent an excellent
platform for studying various fundamental physical phenomena difficult to achieve in the condensed
matter systems. Working with photonic lattices is very comfortable because they are easy to manipulate with
and it is possible to directly observe the wave dynamics. An important property of FBs lattice is that they can
host a complete set of compact localized modes (CLMs), highly robust to environmental noise. Due to lattice
their geometry, it is possible to design artificial gauge field effects which are equivalent to the magnetic field
flux, i. e. the spin-orbit interaction in atomic systems.
We have studied a two-dimensional (2D) linear and nonlinearphotonic lattices dressed by the artificial flux and
have explored the influence of the artificial gauge field on the energy band spectrum. We investigated CLM
in three types of 2D photonic lattices: octagonal-diamond, dice and plus-like lattice. Each of these lattices is
characterized by the presence of diamond plaquettes in the structure. When diamond plaquettes are dressed by
artificial flux, the Aharonov-Bohm effect has caused the appearance of new FBs for certain values of the flux.
The dynamics of the CLMs in the mentioned flux-dressed lattices have been analyzed numerically, using
the Runge-Kutta procedure of the 6th order. To describe the dynamic properties of CLMs, in the presence
of nonlinearity and artificial flux, we calculated some of the following quantities: the participation number,
which is a measure of the mode localization; the mode overlapping, which represents normalized magnitude
of the field overlap; and total intensity distribution. The evolution of these quantities show the efficiency of the
mode compactness andlocalization.",
journal = "WCLOP2023 : 5th World Congress on Lasers, Optics and Photonics : Book of abstracts",
title = "Playing with the artificial flux in diamond plaquettes in different photonic lattices",
pages = "65-65",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11852"
}

Stojanović, M. G., Maluckov, A., Stepić, M.,& Mančić, A.. (2023). Playing with the artificial flux in diamond plaquettes in different photonic lattices. in WCLOP2023 : 5th World Congress on Lasers, Optics and Photonics : Book of abstracts, 65-65.
https://hdl.handle.net/21.15107/rcub_vinar_11852

Stojanović MG, Maluckov A, Stepić M, Mančić A. Playing with the artificial flux in diamond plaquettes in different photonic lattices. in WCLOP2023 : 5th World Congress on Lasers, Optics and Photonics : Book of abstracts. 2023;:65-65.
https://hdl.handle.net/21.15107/rcub_vinar_11852 .

Stojanović, Mirjana G., Maluckov, Aleksandra, Stepić, Milutin, Mančić, Ana, "Playing with the artificial flux in diamond plaquettes in different photonic lattices" in WCLOP2023 : 5th World Congress on Lasers, Optics and Photonics : Book of abstracts (2023):65-65,
https://hdl.handle.net/21.15107/rcub_vinar_11852 .

TY  - CONF
AU  - Stojanović, Mirjana G.
AU  - Mančić, Ana
AU  - Stepić, Milutin
AU  - Maluckov, Aleksandra
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11855
AB  - Flatband (FB) photonic lattices represent ideal testbed for studying transport and localization
properties at the linear level in diverse physical systems [1]. Photonic lattices are easy for manipulation
and investigation of wave dynamics. The photonic lattices offer an ability to design artificial gauge field
effects which are equivalent to the magnetic field flux and the spin-orbit interaction in atomic systems
[2].
The two-dimensional (2D) plus
lattice [3] dressed by the artificial flux can be
experimentally realized by techniques based
on the coupled-spring resonators [4] and
wave-guide networks [5]. Here we tuned the
artificial flux values and studied their effect
on the energy band spectrum and we were
trying to find compact localized modes
(CLMs).
The geometry of the uniform plus
lattice dressed by the artificial flux is Figure
2. Schematic of 2D plus-like lattice with artificial
flux. The unit cell is encircled by a dotted
line.schematically presented in Fig. 1. The
unit cell consists of five sites, linearly coupled with each other with the same intra-cell coupling constant.
The flux of the artificial field modifies the coupling between different unit cell sites to t∙exp(±iϕ/4),
where t is the hopping parameter and ϕ is the artificial flux. In the absence of flux, in the uniform lattice,
the energy spectrum has one fully degenerate FB, centered at zero, and four dispersive bands (DBs) [3].
We have found that this lattice can host the Aharonov-Bohm effect for certain flux values [6]. When
diamond plaquettes are dressed by artificial flux ϕ=π, this lattice spectrum is described by two
momentum independent, fully degenerated FBs, and three DBs. Corresponding CLMs have been
obtained. In the comparison with the flux-free case, we found three different types of fundamental nonorthogonal CLMs now. These CLMs occupy 5 unit cells i.e. are class U=5. The central site amplitude is
zero and all other 4 sites of unit cell have nonzero amplitudes.
PB  - Belgrade : Institute of Physics
C3  - 16th Photonics Workshop : Book of abstracts
T1  - Localized modes in linear flux dressed two-dimensional plus lattice
SP  - 36
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11855
ER  - 

@conference{
author = "Stojanović, Mirjana G. and Mančić, Ana and Stepić, Milutin and Maluckov, Aleksandra",
year = "2023",
abstract = "Flatband (FB) photonic lattices represent ideal testbed for studying transport and localization
properties at the linear level in diverse physical systems [1]. Photonic lattices are easy for manipulation
and investigation of wave dynamics. The photonic lattices offer an ability to design artificial gauge field
effects which are equivalent to the magnetic field flux and the spin-orbit interaction in atomic systems
[2].
The two-dimensional (2D) plus
lattice [3] dressed by the artificial flux can be
experimentally realized by techniques based
on the coupled-spring resonators [4] and
wave-guide networks [5]. Here we tuned the
artificial flux values and studied their effect
on the energy band spectrum and we were
trying to find compact localized modes
(CLMs).
The geometry of the uniform plus
lattice dressed by the artificial flux is Figure
2. Schematic of 2D plus-like lattice with artificial
flux. The unit cell is encircled by a dotted
line.schematically presented in Fig. 1. The
unit cell consists of five sites, linearly coupled with each other with the same intra-cell coupling constant.
The flux of the artificial field modifies the coupling between different unit cell sites to t∙exp(±iϕ/4),
where t is the hopping parameter and ϕ is the artificial flux. In the absence of flux, in the uniform lattice,
the energy spectrum has one fully degenerate FB, centered at zero, and four dispersive bands (DBs) [3].
We have found that this lattice can host the Aharonov-Bohm effect for certain flux values [6]. When
diamond plaquettes are dressed by artificial flux ϕ=π, this lattice spectrum is described by two
momentum independent, fully degenerated FBs, and three DBs. Corresponding CLMs have been
obtained. In the comparison with the flux-free case, we found three different types of fundamental nonorthogonal CLMs now. These CLMs occupy 5 unit cells i.e. are class U=5. The central site amplitude is
zero and all other 4 sites of unit cell have nonzero amplitudes.",
publisher = "Belgrade : Institute of Physics",
journal = "16th Photonics Workshop : Book of abstracts",
title = "Localized modes in linear flux dressed two-dimensional plus lattice",
pages = "36-36",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11855"
}

Stojanović, M. G., Mančić, A., Stepić, M.,& Maluckov, A.. (2023). Localized modes in linear flux dressed two-dimensional plus lattice. in 16th Photonics Workshop : Book of abstracts
Belgrade : Institute of Physics., 36-36.
https://hdl.handle.net/21.15107/rcub_vinar_11855

Stojanović MG, Mančić A, Stepić M, Maluckov A. Localized modes in linear flux dressed two-dimensional plus lattice. in 16th Photonics Workshop : Book of abstracts. 2023;:36-36.
https://hdl.handle.net/21.15107/rcub_vinar_11855 .

Stojanović, Mirjana G., Mančić, Ana, Stepić, Milutin, Maluckov, Aleksandra, "Localized modes in linear flux dressed two-dimensional plus lattice" in 16th Photonics Workshop : Book of abstracts (2023):36-36,
https://hdl.handle.net/21.15107/rcub_vinar_11855 .

TY  - JOUR
AU  - Nešić, Maja D.
AU  - Dučić, Tanja
AU  - Algarra, Manuel
AU  - Popović, Iva A.
AU  - Stepić, Milutin
AU  - Gonçalves, Mara
AU  - Petković, Marijana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10184
AB  - In the last decade, targeting membrane lipids in cancer cells has been a promising approach that deserves attention in the field of anticancer drug development. To get a comprehensive understanding of the effect of the drug [Ru(η5-Cp)(PPh3)2CN] (RuCN) on cell lipidic components, we combine complementary analytical approaches, matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) and synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectroscopy. Techniques are used for screening the effect of potential metallodrug, RuCN, without and with drug carriers (carbon dots (CDs) and nitrogen-doped carbon dots (N-CDs)) on the lipids of the human ovarian cancer cell line A2780. MALDI TOF MS results revealed that the lysis of ovarian cancer membrane lipids is promoted by RuCN and not by drug carriers (CDs and N-CDs). Furthermore, SR-FTIR results strongly suggested that the phospholipids of cancer cells undergo oxidative stress after the treatment with RuCN that was accompanied by the disordering of the fatty acid chains. On the other hand, using (N-)CDs as RuCN nanocarriers prevented the oxidative stress caused by RuCN but did not prevent the disordering of the fatty acid chain packing. Finally, we demonstrated that RuCN and RuCN/(N-)CDs alter the hydration of the membrane surface in the membrane–water interface region.
T2  - Cancers
T1  - Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study
VL  - 14
IS  - 5
SP  - 1182
DO  - 10.3390/cancers14051182
ER  - 

@article{
author = "Nešić, Maja D. and Dučić, Tanja and Algarra, Manuel and Popović, Iva A. and Stepić, Milutin and Gonçalves, Mara and Petković, Marijana",
year = "2022",
abstract = "In the last decade, targeting membrane lipids in cancer cells has been a promising approach that deserves attention in the field of anticancer drug development. To get a comprehensive understanding of the effect of the drug [Ru(η5-Cp)(PPh3)2CN] (RuCN) on cell lipidic components, we combine complementary analytical approaches, matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) and synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectroscopy. Techniques are used for screening the effect of potential metallodrug, RuCN, without and with drug carriers (carbon dots (CDs) and nitrogen-doped carbon dots (N-CDs)) on the lipids of the human ovarian cancer cell line A2780. MALDI TOF MS results revealed that the lysis of ovarian cancer membrane lipids is promoted by RuCN and not by drug carriers (CDs and N-CDs). Furthermore, SR-FTIR results strongly suggested that the phospholipids of cancer cells undergo oxidative stress after the treatment with RuCN that was accompanied by the disordering of the fatty acid chains. On the other hand, using (N-)CDs as RuCN nanocarriers prevented the oxidative stress caused by RuCN but did not prevent the disordering of the fatty acid chain packing. Finally, we demonstrated that RuCN and RuCN/(N-)CDs alter the hydration of the membrane surface in the membrane–water interface region.",
journal = "Cancers",
title = "Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study",
volume = "14",
number = "5",
pages = "1182",
doi = "10.3390/cancers14051182"
}

Nešić, M. D., Dučić, T., Algarra, M., Popović, I. A., Stepić, M., Gonçalves, M.,& Petković, M.. (2022). Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study. in Cancers, 14(5), 1182.
https://doi.org/10.3390/cancers14051182

Nešić MD, Dučić T, Algarra M, Popović IA, Stepić M, Gonçalves M, Petković M. Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study. in Cancers. 2022;14(5):1182.
doi:10.3390/cancers14051182 .

Nešić, Maja D., Dučić, Tanja, Algarra, Manuel, Popović, Iva A., Stepić, Milutin, Gonçalves, Mara, Petković, Marijana, "Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study" in Cancers, 14, no. 5 (2022):1182,
https://doi.org/10.3390/cancers14051182 . .

TY  - JOUR
AU  - Nešić, Maja D.
AU  - Dučić, Tanja
AU  - Gonçalves, Mara
AU  - Stepić, Milutin
AU  - Algarra, Manuel
AU  - Soto, Juan
AU  - Gemović, Branislava S.
AU  - Bandosz, Teresa J.
AU  - Petković, Marijana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10267
AB  - Carbon dots (CDs) and N-carbon dots (N-CDs) loaded with Ru-complex (CDs@RuCN, N-CDs@RuCN, respectively) were investigated as media imposing biochemical changes induced by UV illumination of ovarian cancer, A2780, and osteosarcoma, CAL72, cells. Synchrotron radiation-based Fourier Transform Infrared Spectroscopy was performed, and the spectra were subjected to a Principal Component Analysis. The CDs@RuCN and N-CDs@RuCN effects on cancer cells were analyzed by the theoretical modelling of the stability of the composite systems and a protein database search. Moreover, a detailed evaluation of surface and optical properties of CDs@RuCN and N-CDs@RuCN was carried out. Results demonstrated selective action of the CDs@RuCN and N-CDs@RuCN-based photodynamic therapy, with N-CDs@RuCN being the most active in inducing changes in A2780 and CDs@RuCN in CAL72 cells. We assume that different surface charges of nanoparticles led to direct interactions of N-CDs@RuCN with a Wnt signalling pathway in A2780 and those of CDs@RuCN with PI3–K/Akt in CAL72 cells and that further biochemical changes occurred upon light illumination.
T2  - Chemico-Biological Interactions
T1  - Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex
VL  - 360
SP  - 109950
DO  - 10.1016/j.cbi.2022.109950
ER  - 

@article{
author = "Nešić, Maja D. and Dučić, Tanja and Gonçalves, Mara and Stepić, Milutin and Algarra, Manuel and Soto, Juan and Gemović, Branislava S. and Bandosz, Teresa J. and Petković, Marijana",
year = "2022",
abstract = "Carbon dots (CDs) and N-carbon dots (N-CDs) loaded with Ru-complex (CDs@RuCN, N-CDs@RuCN, respectively) were investigated as media imposing biochemical changes induced by UV illumination of ovarian cancer, A2780, and osteosarcoma, CAL72, cells. Synchrotron radiation-based Fourier Transform Infrared Spectroscopy was performed, and the spectra were subjected to a Principal Component Analysis. The CDs@RuCN and N-CDs@RuCN effects on cancer cells were analyzed by the theoretical modelling of the stability of the composite systems and a protein database search. Moreover, a detailed evaluation of surface and optical properties of CDs@RuCN and N-CDs@RuCN was carried out. Results demonstrated selective action of the CDs@RuCN and N-CDs@RuCN-based photodynamic therapy, with N-CDs@RuCN being the most active in inducing changes in A2780 and CDs@RuCN in CAL72 cells. We assume that different surface charges of nanoparticles led to direct interactions of N-CDs@RuCN with a Wnt signalling pathway in A2780 and those of CDs@RuCN with PI3–K/Akt in CAL72 cells and that further biochemical changes occurred upon light illumination.",
journal = "Chemico-Biological Interactions",
title = "Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex",
volume = "360",
pages = "109950",
doi = "10.1016/j.cbi.2022.109950"
}

Nešić, M. D., Dučić, T., Gonçalves, M., Stepić, M., Algarra, M., Soto, J., Gemović, B. S., Bandosz, T. J.,& Petković, M.. (2022). Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex. in Chemico-Biological Interactions, 360, 109950.
https://doi.org/10.1016/j.cbi.2022.109950

Nešić MD, Dučić T, Gonçalves M, Stepić M, Algarra M, Soto J, Gemović BS, Bandosz TJ, Petković M. Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex. in Chemico-Biological Interactions. 2022;360:109950.
doi:10.1016/j.cbi.2022.109950 .

Nešić, Maja D., Dučić, Tanja, Gonçalves, Mara, Stepić, Milutin, Algarra, Manuel, Soto, Juan, Gemović, Branislava S., Bandosz, Teresa J., Petković, Marijana, "Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex" in Chemico-Biological Interactions, 360 (2022):109950,
https://doi.org/10.1016/j.cbi.2022.109950 . .

TY  - CONF
AU  - Čolakov, Katarina
AU  - Nešić, Maja D.
AU  - Matijević, Milica
AU  - Stepić, Milutin
AU  - Petković, Marijana
AU  - Korićanac, Lela
AU  - Žakula, Jelena
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11011
AB  - Existing therapies for the treatment of pancreatic cancer are insufficiently effective and accompanied by a large number of side effects. Ruthenium complexes have shown promising antitumor properties in the previous studies 1,2 . Thus, in this investigation, anticancer effects of cis-dichlorobis (2,2'-bipyridyl-4,4'dicarboxylic acid)ruthenium(II) (Ru(II) complex) were evaluated using human pancreatic carcinoma cell lines MIA PaCa-2 and PANC-1 in vitro. Cell viability estimated with SRB assay showed significant antitumor activity of Ru(II) complex on MIA PaCa-2 (~55% of control) 48 and 72 h after treatment. On the other hand, PANC-1 cell viability was decreased only 72 h after treatment with the highest concentration of Ru(II) complex (~70% of control). Seven days after the treatment, analysis of cell survival using clonogenic assay showed a significant decrease in cell growth in both cell lines. Ru(II) complex also caused G 1 cell cycle arrest of ~13% in both cell lines. The highest percentage of apoptotic MIA PaCa-2 cells was obtained 48 h after treatment. In addition, the intracellular level of reactive oxygen species (ROS) was significantly increased, whereas cell migration was reduced in both cell lines. Summarized, Ru(II)complex demonstrates antitumor properties mediated by increased oxidative stress and also implies the antimetastatic potential, which deserves further study.
PB  - Belgrade : Faculty of Chemistry : Serbian Biochemical Society
C3  - Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia
T1  - ROS-mediated proapoptotic antitumor effects of Ru(II) complex on pancreatic cancer cells
SP  - 155
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11011
ER  - 

@conference{
author = "Čolakov, Katarina and Nešić, Maja D. and Matijević, Milica and Stepić, Milutin and Petković, Marijana and Korićanac, Lela and Žakula, Jelena",
year = "2022",
abstract = "Existing therapies for the treatment of pancreatic cancer are insufficiently effective and accompanied by a large number of side effects. Ruthenium complexes have shown promising antitumor properties in the previous studies 1,2 . Thus, in this investigation, anticancer effects of cis-dichlorobis (2,2'-bipyridyl-4,4'dicarboxylic acid)ruthenium(II) (Ru(II) complex) were evaluated using human pancreatic carcinoma cell lines MIA PaCa-2 and PANC-1 in vitro. Cell viability estimated with SRB assay showed significant antitumor activity of Ru(II) complex on MIA PaCa-2 (~55% of control) 48 and 72 h after treatment. On the other hand, PANC-1 cell viability was decreased only 72 h after treatment with the highest concentration of Ru(II) complex (~70% of control). Seven days after the treatment, analysis of cell survival using clonogenic assay showed a significant decrease in cell growth in both cell lines. Ru(II) complex also caused G 1 cell cycle arrest of ~13% in both cell lines. The highest percentage of apoptotic MIA PaCa-2 cells was obtained 48 h after treatment. In addition, the intracellular level of reactive oxygen species (ROS) was significantly increased, whereas cell migration was reduced in both cell lines. Summarized, Ru(II)complex demonstrates antitumor properties mediated by increased oxidative stress and also implies the antimetastatic potential, which deserves further study.",
publisher = "Belgrade : Faculty of Chemistry : Serbian Biochemical Society",
journal = "Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia",
title = "ROS-mediated proapoptotic antitumor effects of Ru(II) complex on pancreatic cancer cells",
pages = "155",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11011"
}

Čolakov, K., Nešić, M. D., Matijević, M., Stepić, M., Petković, M., Korićanac, L.,& Žakula, J.. (2022). ROS-mediated proapoptotic antitumor effects of Ru(II) complex on pancreatic cancer cells. in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia
Belgrade : Faculty of Chemistry : Serbian Biochemical Society., 155.
https://hdl.handle.net/21.15107/rcub_vinar_11011

Čolakov K, Nešić MD, Matijević M, Stepić M, Petković M, Korićanac L, Žakula J. ROS-mediated proapoptotic antitumor effects of Ru(II) complex on pancreatic cancer cells. in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia. 2022;:155.
https://hdl.handle.net/21.15107/rcub_vinar_11011 .

Čolakov, Katarina, Nešić, Maja D., Matijević, Milica, Stepić, Milutin, Petković, Marijana, Korićanac, Lela, Žakula, Jelena, "ROS-mediated proapoptotic antitumor effects of Ru(II) complex on pancreatic cancer cells" in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia (2022):155,
https://hdl.handle.net/21.15107/rcub_vinar_11011 .

TY  - JOUR
AU  - Stojanović, Mirjana G.
AU  - Mančić, Ana
AU  - Stepić, Milutin
AU  - Maluckov, Aleksandra
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11839
AB  - Two-dimensional dice lattice can be dressed by artificial flux to host the Aharonov-Bohm (AB) caging effect resulting in the occurrence of a fully flatband spectrum. Here, we focus on the dynamics of flatband compact localized eigenmodes shared by a few unit cells in two snowflake configurations. We numerically show the possibility of dynamically stable propagation of two types of compact localized complexes by tuning the nonlinearity. The caging is imprinted in complexes dynamics regardless of the type and strength of nonlinearity. On the other hand, nonlinearity can only affect the appearance of the caged complex. These findings open a new route for the manipulation of structured light in photonic systems.
AB  - Uslovi za generisanje Aharonov-Bohm (AB) efekta mogu se postići u dvodimenzionalnoj rombičnoj rešetki s veštački indukovanim fluksom, što dovodi do formiranja energetskog spektra s potpuno ravnim zonama. U radu, akcenat je stavljen na proučavanje dinamike kompaktnih lokalizovanih svojstvenih moda ravnih zona, koje su izolovane na svega nekoliko jediničnih ćelija rešetke u dve pahuljičaste konfiguracije. Numerički je pokazana mogućnost stabilnog prostiranja dva tipa kompaktnih lokalizovanih kompleksa uz pogodno podešavanje nelinearnih svojstava rešetke. AB zarobljavanje igra dominantnu ulogu kada je reč o dinamici kompleksa, bez obzira na vrstu i jačinu nelinearnosti, koja, sa svoje strane, može uticati na oblik zarobljene strukture. Naša otkrića pružaju nove mogućnosti za unapređivanje načina za manipulisanje svetlošću u fotonskim sistemima.
T2  - Facta universitatis series: Physics, Chemistry and Technology
T1  - Shaping the dynamics of Aharonov-Bohm caged localized modes by nonlinearity
T1  - Oblikovanje dinamike Aharonov-Bohm zarobljenih lokalizovanih moda posredstvom nelinearnosti
VL  - 20
IS  - 1
SP  - 55
EP  - 65
DO  - 10.2298/FUPCT2201055S
ER  - 

@article{
author = "Stojanović, Mirjana G. and Mančić, Ana and Stepić, Milutin and Maluckov, Aleksandra",
year = "2022",
abstract = "Two-dimensional dice lattice can be dressed by artificial flux to host the Aharonov-Bohm (AB) caging effect resulting in the occurrence of a fully flatband spectrum. Here, we focus on the dynamics of flatband compact localized eigenmodes shared by a few unit cells in two snowflake configurations. We numerically show the possibility of dynamically stable propagation of two types of compact localized complexes by tuning the nonlinearity. The caging is imprinted in complexes dynamics regardless of the type and strength of nonlinearity. On the other hand, nonlinearity can only affect the appearance of the caged complex. These findings open a new route for the manipulation of structured light in photonic systems., Uslovi za generisanje Aharonov-Bohm (AB) efekta mogu se postići u dvodimenzionalnoj rombičnoj rešetki s veštački indukovanim fluksom, što dovodi do formiranja energetskog spektra s potpuno ravnim zonama. U radu, akcenat je stavljen na proučavanje dinamike kompaktnih lokalizovanih svojstvenih moda ravnih zona, koje su izolovane na svega nekoliko jediničnih ćelija rešetke u dve pahuljičaste konfiguracije. Numerički je pokazana mogućnost stabilnog prostiranja dva tipa kompaktnih lokalizovanih kompleksa uz pogodno podešavanje nelinearnih svojstava rešetke. AB zarobljavanje igra dominantnu ulogu kada je reč o dinamici kompleksa, bez obzira na vrstu i jačinu nelinearnosti, koja, sa svoje strane, može uticati na oblik zarobljene strukture. Naša otkrića pružaju nove mogućnosti za unapređivanje načina za manipulisanje svetlošću u fotonskim sistemima.",
journal = "Facta universitatis series: Physics, Chemistry and Technology",
title = "Shaping the dynamics of Aharonov-Bohm caged localized modes by nonlinearity, Oblikovanje dinamike Aharonov-Bohm zarobljenih lokalizovanih moda posredstvom nelinearnosti",
volume = "20",
number = "1",
pages = "55-65",
doi = "10.2298/FUPCT2201055S"
}

Stojanović, M. G., Mančić, A., Stepić, M.,& Maluckov, A.. (2022). Shaping the dynamics of Aharonov-Bohm caged localized modes by nonlinearity. in Facta universitatis series: Physics, Chemistry and Technology, 20(1), 55-65.
https://doi.org/10.2298/FUPCT2201055S

Stojanović MG, Mančić A, Stepić M, Maluckov A. Shaping the dynamics of Aharonov-Bohm caged localized modes by nonlinearity. in Facta universitatis series: Physics, Chemistry and Technology. 2022;20(1):55-65.
doi:10.2298/FUPCT2201055S .

Stojanović, Mirjana G., Mančić, Ana, Stepić, Milutin, Maluckov, Aleksandra, "Shaping the dynamics of Aharonov-Bohm caged localized modes by nonlinearity" in Facta universitatis series: Physics, Chemistry and Technology, 20, no. 1 (2022):55-65,
https://doi.org/10.2298/FUPCT2201055S . .

TY  - CONF
AU  - Stepić, Milutin
AU  - Maluckov, Aleksandra
AU  - Mančić, Ana
AU  - Stojanović, Mirjana G.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11851
AB  - Flatband (FB) photonic systems have been in the spotlight of researchers since they
represent an advantageous testbed for studying transport and localization properties at the linear level [1]. Among variety of platforms where flatbands have been
realized photonic lattices have been established as the ideal ones, since working
with them is very comfortable - they are easy to manipulate with and it is possible
to directly observe the wave dynamics. Due to their geometry, it is possible to design artificial gauge field effects which are equivalent to the magnetic field flux, i.
e. the spin-orbit interaction in atomic systems [2].
Here, we study a two-dimensional (2D) pluslike lattice [3], dressed by the artificial
flux, which could be realized by experimental techniques based on the coupledspring resonators [4] and wave-guide networks [5]. We investigate the influence of
the artificial flux on the energy band spectrum and the idea is to find the compact
localized modes (CLM).
The unit cell of the plus lattice consists of five sites, with real intra-cell hopping
represented by the coupling coefficient. The flux of the artificial field modifies the
coupling between different unit cell sites to t∙exp(±iϕ/4), where tis the hopping parameter and ϕ is the artificial flux. In the absence of flux, in the uniform lattice,
the energy spectrum has one fully degenerate FB, centered at zero, between two
dispersive bands (DBs), each of which is being accompanied with the other mirror
symmetric DB [3]. We have found that 2D plus lattice can be dressed by artificial
flux to host the Aharonov-Bohm (AB) effect. This effect causes the appearance of
flat zones in the energy spectrum of the lattice. Hence, when diamond plaquettes are dressed by artificial flux ϕ=π, this lattice spectrum is described by two momentum independent, fully degenerated FBs, and three DBs.
The dynamics of CLMs in 2D flux-dressed plus lattice can be analyzed numerically,
adopting the Runge-Kutta procedure of the 6th order. In order to scan the dynamical properties of the CLMs we will calculate some of the following quantities: the
participation number, which is a measure of the mode localization; the mode overlapping, which represents normalized magnitude of the field overlap; and total intensity distribution. The evolution of these quantities will show the efficiency of
the mode compactness-localization.
C3  - BPU11 : 11th International Conference of the Balkan Physical Union
T1  - Existence and dynamics of eigenmodes in linear flux dressed two-dimensional plus lattice
VL  - 427
SP  - 149
EP  - 150
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11851
ER  - 

@conference{
author = "Stepić, Milutin and Maluckov, Aleksandra and Mančić, Ana and Stojanović, Mirjana G.",
year = "2022",
abstract = "Flatband (FB) photonic systems have been in the spotlight of researchers since they
represent an advantageous testbed for studying transport and localization properties at the linear level [1]. Among variety of platforms where flatbands have been
realized photonic lattices have been established as the ideal ones, since working
with them is very comfortable - they are easy to manipulate with and it is possible
to directly observe the wave dynamics. Due to their geometry, it is possible to design artificial gauge field effects which are equivalent to the magnetic field flux, i.
e. the spin-orbit interaction in atomic systems [2].
Here, we study a two-dimensional (2D) pluslike lattice [3], dressed by the artificial
flux, which could be realized by experimental techniques based on the coupledspring resonators [4] and wave-guide networks [5]. We investigate the influence of
the artificial flux on the energy band spectrum and the idea is to find the compact
localized modes (CLM).
The unit cell of the plus lattice consists of five sites, with real intra-cell hopping
represented by the coupling coefficient. The flux of the artificial field modifies the
coupling between different unit cell sites to t∙exp(±iϕ/4), where tis the hopping parameter and ϕ is the artificial flux. In the absence of flux, in the uniform lattice,
the energy spectrum has one fully degenerate FB, centered at zero, between two
dispersive bands (DBs), each of which is being accompanied with the other mirror
symmetric DB [3]. We have found that 2D plus lattice can be dressed by artificial
flux to host the Aharonov-Bohm (AB) effect. This effect causes the appearance of
flat zones in the energy spectrum of the lattice. Hence, when diamond plaquettes are dressed by artificial flux ϕ=π, this lattice spectrum is described by two momentum independent, fully degenerated FBs, and three DBs.
The dynamics of CLMs in 2D flux-dressed plus lattice can be analyzed numerically,
adopting the Runge-Kutta procedure of the 6th order. In order to scan the dynamical properties of the CLMs we will calculate some of the following quantities: the
participation number, which is a measure of the mode localization; the mode overlapping, which represents normalized magnitude of the field overlap; and total intensity distribution. The evolution of these quantities will show the efficiency of
the mode compactness-localization.",
journal = "BPU11 : 11th International Conference of the Balkan Physical Union",
title = "Existence and dynamics of eigenmodes in linear flux dressed two-dimensional plus lattice",
volume = "427",
pages = "149-150",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11851"
}

Stepić, M., Maluckov, A., Mančić, A.,& Stojanović, M. G.. (2022). Existence and dynamics of eigenmodes in linear flux dressed two-dimensional plus lattice. in BPU11 : 11th International Conference of the Balkan Physical Union, 427, 149-150.
https://hdl.handle.net/21.15107/rcub_vinar_11851

Stepić M, Maluckov A, Mančić A, Stojanović MG. Existence and dynamics of eigenmodes in linear flux dressed two-dimensional plus lattice. in BPU11 : 11th International Conference of the Balkan Physical Union. 2022;427:149-150.
https://hdl.handle.net/21.15107/rcub_vinar_11851 .

Stepić, Milutin, Maluckov, Aleksandra, Mančić, Ana, Stojanović, Mirjana G., "Existence and dynamics of eigenmodes in linear flux dressed two-dimensional plus lattice" in BPU11 : 11th International Conference of the Balkan Physical Union, 427 (2022):149-150,
https://hdl.handle.net/21.15107/rcub_vinar_11851 .

TY  - CONF
AU  - Stojanović, Mirjana G.
AU  - Mančić, Ana
AU  - Stepić, Milutin
AU  - Maluckov, Aleksandra
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11854
C3  - 15th Photonics Workshop : Book of abstracts
T1  - Dynamics of nonlinear Aharonov-Bohm caged compact localized modes in Dice lattice
SP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11854
ER  - 

@conference{
author = "Stojanović, Mirjana G. and Mančić, Ana and Stepić, Milutin and Maluckov, Aleksandra",
year = "2022",
journal = "15th Photonics Workshop : Book of abstracts",
title = "Dynamics of nonlinear Aharonov-Bohm caged compact localized modes in Dice lattice",
pages = "28",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11854"
}

Stojanović, M. G., Mančić, A., Stepić, M.,& Maluckov, A.. (2022). Dynamics of nonlinear Aharonov-Bohm caged compact localized modes in Dice lattice. in 15th Photonics Workshop : Book of abstracts, 28.
https://hdl.handle.net/21.15107/rcub_vinar_11854

Stojanović MG, Mančić A, Stepić M, Maluckov A. Dynamics of nonlinear Aharonov-Bohm caged compact localized modes in Dice lattice. in 15th Photonics Workshop : Book of abstracts. 2022;:28.
https://hdl.handle.net/21.15107/rcub_vinar_11854 .

Stojanović, Mirjana G., Mančić, Ana, Stepić, Milutin, Maluckov, Aleksandra, "Dynamics of nonlinear Aharonov-Bohm caged compact localized modes in Dice lattice" in 15th Photonics Workshop : Book of abstracts (2022):28,
https://hdl.handle.net/21.15107/rcub_vinar_11854 .

TY  - JOUR
AU  - Stojanović, Mirjana G.
AU  - Gundogdu, Sinan
AU  - Leykam, Daniel
AU  - Angelakis, Dimitris G.
AU  - Stojanović Krasić, Marija
AU  - Stepić, Milutin
AU  - Maluckov, Aleksandra
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10197
AB  - Tuning the values of artificial flux in the two-dimensional octagonal-diamond lattice drives topological phase transitions, including between singular and non-singular flatbands. We study the dynamical properties of nonlinear compact localized modes that can be continued from linear flatband modes. We show how the stability of the compact localized modes can be tuned by the nonlinearity strength or the applied artificial flux. Our model can be realized using ring resonator lattices or nonlinear waveguide arrays.
T2  - Physica Scripta
T1  - Nonlinear compact localized modes in flux-dressed octagonal-diamond lattice
VL  - 97
IS  - 3
SP  - 030006
DO  - 10.1088/1402-4896/ac5357
ER  - 

@article{
author = "Stojanović, Mirjana G. and Gundogdu, Sinan and Leykam, Daniel and Angelakis, Dimitris G. and Stojanović Krasić, Marija and Stepić, Milutin and Maluckov, Aleksandra",
year = "2022",
abstract = "Tuning the values of artificial flux in the two-dimensional octagonal-diamond lattice drives topological phase transitions, including between singular and non-singular flatbands. We study the dynamical properties of nonlinear compact localized modes that can be continued from linear flatband modes. We show how the stability of the compact localized modes can be tuned by the nonlinearity strength or the applied artificial flux. Our model can be realized using ring resonator lattices or nonlinear waveguide arrays.",
journal = "Physica Scripta",
title = "Nonlinear compact localized modes in flux-dressed octagonal-diamond lattice",
volume = "97",
number = "3",
pages = "030006",
doi = "10.1088/1402-4896/ac5357"
}

Stojanović, M. G., Gundogdu, S., Leykam, D., Angelakis, D. G., Stojanović Krasić, M., Stepić, M.,& Maluckov, A.. (2022). Nonlinear compact localized modes in flux-dressed octagonal-diamond lattice. in Physica Scripta, 97(3), 030006.
https://doi.org/10.1088/1402-4896/ac5357

Stojanović MG, Gundogdu S, Leykam D, Angelakis DG, Stojanović Krasić M, Stepić M, Maluckov A. Nonlinear compact localized modes in flux-dressed octagonal-diamond lattice. in Physica Scripta. 2022;97(3):030006.
doi:10.1088/1402-4896/ac5357 .

Stojanović, Mirjana G., Gundogdu, Sinan, Leykam, Daniel, Angelakis, Dimitris G., Stojanović Krasić, Marija, Stepić, Milutin, Maluckov, Aleksandra, "Nonlinear compact localized modes in flux-dressed octagonal-diamond lattice" in Physica Scripta, 97, no. 3 (2022):030006,
https://doi.org/10.1088/1402-4896/ac5357 . .

TY  - JOUR
AU  - Mančić, Ana
AU  - Stojanović, Mirjana G.
AU  - Stepić, Milutin
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10965
AB  - It was studied a photonic linear two-dimensional plus lattice dressed by the artificial flux and explored the influence of the artificial gauge field on the energy band spectrum. The Aharonov-Bohm effect has caused the appearance of flat zones and for certain values of the flux, the lattice spectrum has been described by two momentum independent, fully degenerated flatbands and three dispersive bands. Three different types of fundamental non-orthogonal compactons have been obtained. The findings presented in this study could be tested in practice and they may be used for probing different artificial flatband systems, e. g. ultracold atoms in optical lattices, polariton condensates etc.
AB  - U ovom radu proučavana je fotonska linearna dvodimenziona plus rešetka tretirana fluksom kalibracionog polja kao i uticaj veštačkog kalibracionog polja, na energetski spektar. Usled Aharonov-Bomovog efekta dolazi do pojave ravnih zona i za određene vrednosti fluksa energetski spektar rešetke može se opisati sa dve potpuno degenerisane ravne zone i tri disperzivne zone. Pronađena su tri različita tipa fundamentalnih ne-ortogonalnih kompaktona. Predstavljeni rezultati mogu se proveriti u praksi i imaju potencijal za primenu u različitim okruženjima, kao što su mreže superprovodnih žica, topološke rešetke itd.
T2  - Advanced Technologies
T1  - Linear compact localized modes in flux-dressed two-dimensional plus lattice
T1  - Linearne kompaktne lokalizovane mode u dvodimenzionalnoj, fluksom tretiranoj, plus rešetki
VL  - 11
IS  - 2
SP  - 36
EP  - 39
DO  - 10.5937/savteh2202036M
ER  - 

@article{
author = "Mančić, Ana and Stojanović, Mirjana G. and Stepić, Milutin",
year = "2022",
abstract = "It was studied a photonic linear two-dimensional plus lattice dressed by the artificial flux and explored the influence of the artificial gauge field on the energy band spectrum. The Aharonov-Bohm effect has caused the appearance of flat zones and for certain values of the flux, the lattice spectrum has been described by two momentum independent, fully degenerated flatbands and three dispersive bands. Three different types of fundamental non-orthogonal compactons have been obtained. The findings presented in this study could be tested in practice and they may be used for probing different artificial flatband systems, e. g. ultracold atoms in optical lattices, polariton condensates etc., U ovom radu proučavana je fotonska linearna dvodimenziona plus rešetka tretirana fluksom kalibracionog polja kao i uticaj veštačkog kalibracionog polja, na energetski spektar. Usled Aharonov-Bomovog efekta dolazi do pojave ravnih zona i za određene vrednosti fluksa energetski spektar rešetke može se opisati sa dve potpuno degenerisane ravne zone i tri disperzivne zone. Pronađena su tri različita tipa fundamentalnih ne-ortogonalnih kompaktona. Predstavljeni rezultati mogu se proveriti u praksi i imaju potencijal za primenu u različitim okruženjima, kao što su mreže superprovodnih žica, topološke rešetke itd.",
journal = "Advanced Technologies",
title = "Linear compact localized modes in flux-dressed two-dimensional plus lattice, Linearne kompaktne lokalizovane mode u dvodimenzionalnoj, fluksom tretiranoj, plus rešetki",
volume = "11",
number = "2",
pages = "36-39",
doi = "10.5937/savteh2202036M"
}

Mančić, A., Stojanović, M. G.,& Stepić, M.. (2022). Linear compact localized modes in flux-dressed two-dimensional plus lattice. in Advanced Technologies, 11(2), 36-39.
https://doi.org/10.5937/savteh2202036M

Mančić A, Stojanović MG, Stepić M. Linear compact localized modes in flux-dressed two-dimensional plus lattice. in Advanced Technologies. 2022;11(2):36-39.
doi:10.5937/savteh2202036M .

Mančić, Ana, Stojanović, Mirjana G., Stepić, Milutin, "Linear compact localized modes in flux-dressed two-dimensional plus lattice" in Advanced Technologies, 11, no. 2 (2022):36-39,
https://doi.org/10.5937/savteh2202036M . .

TY  - CONF
AU  - Stojanović, Mirjana G.
AU  - Stojanović Krasić, Marija
AU  - Johansson, M.
AU  - Salinas, I.A.
AU  - Vicencio, R.A.
AU  - Stepić, Milutin
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11850
AB  - Flat-band (FB) photonic lattices are attracting substantial attention of researchers
since they provide an excellent platform for studying various fundamental physical
phenomena difficult to achieve in the condensed matter systems. In that regard,
some of those phenomena demonstrated in the last two decade are discrete solitons,
dynamical localization and Anderson localization in disordered lattices [1]. One of
the advantages of photonic lattices is that they are easy to manipulate with. Maybe
the most important property of FBs is that they can host a complete set of compact
localized states (CLS), highly robust to environmental noise.
Here, we investigate the CLS in two-dimensional (2D) dice lattice dressed by artificial flux in the presence of nonlinearity. Due to the Aharonov-Bohm (AB) caging
effect, this lattice can host a fully FB spectrum [2]. The FB eigenmodes are compact
snowflake-like structures shared by a few unit cells [3]. The goal is to find suitable
conditions for selecting the localized states with user-friendly characteristics. We
do this by testing the dynamics of those snowflake-like CLS in the linear and nonlinear regime. We have found two types of dynamics of compact structures, one,
the snowflake-like, robust in both linear and nonlinear regime, and the other one,
breathing complexes, robust only in the presence of weak nonlinearity
C3  - BPU11 : 11th International Conference of the Balkan Physical Union
T1  - Compact localized modes in Dice lattice dressed by artificial flux
VL  - 427
SP  - 146
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11850
ER  - 

@conference{
author = "Stojanović, Mirjana G. and Stojanović Krasić, Marija and Johansson, M. and Salinas, I.A. and Vicencio, R.A. and Stepić, Milutin",
year = "2022",
abstract = "Flat-band (FB) photonic lattices are attracting substantial attention of researchers
since they provide an excellent platform for studying various fundamental physical
phenomena difficult to achieve in the condensed matter systems. In that regard,
some of those phenomena demonstrated in the last two decade are discrete solitons,
dynamical localization and Anderson localization in disordered lattices [1]. One of
the advantages of photonic lattices is that they are easy to manipulate with. Maybe
the most important property of FBs is that they can host a complete set of compact
localized states (CLS), highly robust to environmental noise.
Here, we investigate the CLS in two-dimensional (2D) dice lattice dressed by artificial flux in the presence of nonlinearity. Due to the Aharonov-Bohm (AB) caging
effect, this lattice can host a fully FB spectrum [2]. The FB eigenmodes are compact
snowflake-like structures shared by a few unit cells [3]. The goal is to find suitable
conditions for selecting the localized states with user-friendly characteristics. We
do this by testing the dynamics of those snowflake-like CLS in the linear and nonlinear regime. We have found two types of dynamics of compact structures, one,
the snowflake-like, robust in both linear and nonlinear regime, and the other one,
breathing complexes, robust only in the presence of weak nonlinearity",
journal = "BPU11 : 11th International Conference of the Balkan Physical Union",
title = "Compact localized modes in Dice lattice dressed by artificial flux",
volume = "427",
pages = "146-146",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11850"
}

Stojanović, M. G., Stojanović Krasić, M., Johansson, M., Salinas, I.A., Vicencio, R.A.,& Stepić, M.. (2022). Compact localized modes in Dice lattice dressed by artificial flux. in BPU11 : 11th International Conference of the Balkan Physical Union, 427, 146-146.
https://hdl.handle.net/21.15107/rcub_vinar_11850

Stojanović MG, Stojanović Krasić M, Johansson M, Salinas I, Vicencio R, Stepić M. Compact localized modes in Dice lattice dressed by artificial flux. in BPU11 : 11th International Conference of the Balkan Physical Union. 2022;427:146-146.
https://hdl.handle.net/21.15107/rcub_vinar_11850 .

Stojanović, Mirjana G., Stojanović Krasić, Marija, Johansson, M., Salinas, I.A., Vicencio, R.A., Stepić, Milutin, "Compact localized modes in Dice lattice dressed by artificial flux" in BPU11 : 11th International Conference of the Balkan Physical Union, 427 (2022):146-146,
https://hdl.handle.net/21.15107/rcub_vinar_11850 .

TY  - JOUR
AU  - Matijević, Milica
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Radoičić, Marija B.
AU  - Liang, Xinyue
AU  - Mi, Lan
AU  - Filipović Tričković, Jelena G.
AU  - Valenta-Šobot, Ana
AU  - Stanković, Maja N.
AU  - Nakarada, Đura
AU  - Mojović, Miloš
AU  - Petković, Marijana
AU  - Stepić, Milutin
AU  - Nešić, Maja D.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9908
AB  - In this study, C-doped TiO2 nanoparticles (C-TiO2) were prepared and tested as a photosensitizer for visible-light-driven photodynamic therapy against cervical cancer cells (HeLa). X-ray diffraction and Transmission Electron Microscopy confirmed the anatase form of nanoparticles, spherical shape, and size distribution from 5 to 15 nm. Ultraviolet–visible light spectroscopy showed that C doping of TiO2 enhances the optical absorption in the visible light range caused by a bandgap narrowing. The photo-cytotoxic activity of C-TiO2 was investigated in vitro against HeLa cells. The lack of dark cytotoxicity indicates good biocompatibility of C-TiO2. In contrast, a combination with blue light significantly reduced the survival of HeLa cells: illumination only decreased cell viability by 30% (15 min of illumination, 120 µW power), and 60% when HeLa cells were preincubated with C-TiO2. We have also confirmed blue light-induced C-TiO2-catalyzed generation of reactive oxygen species in vitro and intracellularly. Oxidative stress triggered by C-TiO2/blue light was the leading cause of HeLa cell death. Fluorescent labeling of treated HeLa cells showed distinct morphological changes after the C-TiO2/blue light treatment. Unlike blue light illumination, which caused the appearance of large necrotic cells with deformed nuclei, cytoplasm swelling, and membrane blebbing, a combination of C-TiO2/blue light leads to controlled cell death, thus providing a better outcome of local anticancer therapy.
T2  - Photochemical and Photobiological Sciences
T1  - Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles
VL  - 20
IS  - 8
SP  - 1087
EP  - 1098
DO  - 10.1007/s43630-021-00082-2
ER  - 

@article{
author = "Matijević, Milica and Žakula, Jelena and Korićanac, Lela and Radoičić, Marija B. and Liang, Xinyue and Mi, Lan and Filipović Tričković, Jelena G. and Valenta-Šobot, Ana and Stanković, Maja N. and Nakarada, Đura and Mojović, Miloš and Petković, Marijana and Stepić, Milutin and Nešić, Maja D.",
year = "2021",
abstract = "In this study, C-doped TiO2 nanoparticles (C-TiO2) were prepared and tested as a photosensitizer for visible-light-driven photodynamic therapy against cervical cancer cells (HeLa). X-ray diffraction and Transmission Electron Microscopy confirmed the anatase form of nanoparticles, spherical shape, and size distribution from 5 to 15 nm. Ultraviolet–visible light spectroscopy showed that C doping of TiO2 enhances the optical absorption in the visible light range caused by a bandgap narrowing. The photo-cytotoxic activity of C-TiO2 was investigated in vitro against HeLa cells. The lack of dark cytotoxicity indicates good biocompatibility of C-TiO2. In contrast, a combination with blue light significantly reduced the survival of HeLa cells: illumination only decreased cell viability by 30% (15 min of illumination, 120 µW power), and 60% when HeLa cells were preincubated with C-TiO2. We have also confirmed blue light-induced C-TiO2-catalyzed generation of reactive oxygen species in vitro and intracellularly. Oxidative stress triggered by C-TiO2/blue light was the leading cause of HeLa cell death. Fluorescent labeling of treated HeLa cells showed distinct morphological changes after the C-TiO2/blue light treatment. Unlike blue light illumination, which caused the appearance of large necrotic cells with deformed nuclei, cytoplasm swelling, and membrane blebbing, a combination of C-TiO2/blue light leads to controlled cell death, thus providing a better outcome of local anticancer therapy.",
journal = "Photochemical and Photobiological Sciences",
title = "Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles",
volume = "20",
number = "8",
pages = "1087-1098",
doi = "10.1007/s43630-021-00082-2"
}

Matijević, M., Žakula, J., Korićanac, L., Radoičić, M. B., Liang, X., Mi, L., Filipović Tričković, J. G., Valenta-Šobot, A., Stanković, M. N., Nakarada, Đ., Mojović, M., Petković, M., Stepić, M.,& Nešić, M. D.. (2021). Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles. in Photochemical and Photobiological Sciences, 20(8), 1087-1098.
https://doi.org/10.1007/s43630-021-00082-2

Matijević M, Žakula J, Korićanac L, Radoičić MB, Liang X, Mi L, Filipović Tričković JG, Valenta-Šobot A, Stanković MN, Nakarada Đ, Mojović M, Petković M, Stepić M, Nešić MD. Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles. in Photochemical and Photobiological Sciences. 2021;20(8):1087-1098.
doi:10.1007/s43630-021-00082-2 .

Matijević, Milica, Žakula, Jelena, Korićanac, Lela, Radoičić, Marija B., Liang, Xinyue, Mi, Lan, Filipović Tričković, Jelena G., Valenta-Šobot, Ana, Stanković, Maja N., Nakarada, Đura, Mojović, Miloš, Petković, Marijana, Stepić, Milutin, Nešić, Maja D., "Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles" in Photochemical and Photobiological Sciences, 20, no. 8 (2021):1087-1098,
https://doi.org/10.1007/s43630-021-00082-2 . .