Stojanovic, Marko

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orcid::0000-0003-2097-7591
  • Stojanovic, Marko (2)
  • Stojanović, Marko (1)
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Author's Bibliography

Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art

Medić, Branislava; Stojanović, Marko; Stimec, Bojan V.; Divac, Nevena; Savić Vujović, Katarina; Stojanović, Radan; Čolović, Mirjana B.; Krstić, Danijela; Prostran, Milica

(2020)

TY  - JOUR
AU  - Medić, Branislava
AU  - Stojanović, Marko
AU  - Stimec, Bojan V.
AU  - Divac, Nevena
AU  - Savić Vujović, Katarina
AU  - Stojanović, Radan
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela
AU  - Prostran, Milica
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8838
AB  - Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases. Recent evidence suggested that lithium also possesses some anticancer properties due to its inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) which is included in the regulation of a lot of important cellular processes such as: glycogen metabolism, inflammation, immunomodulation, apoptosis, tissue injury, regeneration etc. Although recent evidence suggested a potential utility of lithium in different conditions, its broader use in clinical practice still trails. The reason for this is a narrow therapeutic index of lithium, numerous toxic effects in various organ systems and some clinically relevant interactions with other drugs. Additionally, it is necessary to perform more preclinical as well as clinical studies in order to a precise therapeutic range of lithium, as well as its detailed mechanism of action. The aim of this review is to summarize the current knowledge concerning the pharmacological and toxicological effects of lithium. © 2020 Bentham Science Publishers.
T2  - Current Medicinal Chemistry
T1  - Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art
VL  - 27
IS  - 3
SP  - 337
EP  - 351
DO  - 10.2174/0929867325666180904124733
ER  - 
@article{
author = "Medić, Branislava and Stojanović, Marko and Stimec, Bojan V. and Divac, Nevena and Savić Vujović, Katarina and Stojanović, Radan and Čolović, Mirjana B. and Krstić, Danijela and Prostran, Milica",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/8838",
abstract = "Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases. Recent evidence suggested that lithium also possesses some anticancer properties due to its inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) which is included in the regulation of a lot of important cellular processes such as: glycogen metabolism, inflammation, immunomodulation, apoptosis, tissue injury, regeneration etc. Although recent evidence suggested a potential utility of lithium in different conditions, its broader use in clinical practice still trails. The reason for this is a narrow therapeutic index of lithium, numerous toxic effects in various organ systems and some clinically relevant interactions with other drugs. Additionally, it is necessary to perform more preclinical as well as clinical studies in order to a precise therapeutic range of lithium, as well as its detailed mechanism of action. The aim of this review is to summarize the current knowledge concerning the pharmacological and toxicological effects of lithium. © 2020 Bentham Science Publishers.",
journal = "Current Medicinal Chemistry",
title = "Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art",
volume = "27",
number = "3",
pages = "337-351",
doi = "10.2174/0929867325666180904124733"
}
Medić, B., Stojanović, M., Stimec, B. V., Divac, N., Savić Vujović, K., Stojanović, R., Čolović, M. B., Krstić, D.,& Prostran, M. (2020). Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art.
Current Medicinal Chemistry, 27(3), 337-351.
https://doi.org/10.2174/0929867325666180904124733
Medić B, Stojanović M, Stimec BV, Divac N, Savić Vujović K, Stojanović R, Čolović MB, Krstić D, Prostran M. Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art. Current Medicinal Chemistry. 2020;27(3):337-351
Medić Branislava, Stojanović Marko, Stimec Bojan V., Divac Nevena, Savić Vujović Katarina, Stojanović Radan, Čolović Mirjana B., Krstić Danijela, Prostran Milica, "Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art" Current Medicinal Chemistry, 27, no. 3 (2020):337-351,
https://doi.org/10.2174/0929867325666180904124733 .
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Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity

Čolović, Mirjana B.; Medic, Branislava; Cetkovic, Mila; Kravić-Stevović, Tamara K.; Stojanovic, Marko; Ayass, Wassim W.; Mougharbel, Ali S.; Radenković, Miroslav; Prostran, Milica; Kortz, Ulrich; Krstić, Danijela Z.

(2017)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Medic, Branislava
AU  - Cetkovic, Mila
AU  - Kravić-Stevović, Tamara K.
AU  - Stojanovic, Marko
AU  - Ayass, Wassim W.
AU  - Mougharbel, Ali S.
AU  - Radenković, Miroslav
AU  - Prostran, Milica
AU  - Kortz, Ulrich
AU  - Krstić, Danijela Z.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1748
AB  - A toxicity evaluation of two Keggin-type heteropolytungstates, K-7[Ti2PW10O40].6H(2)O and K6H [SiV3W9O40].3H(2)O, with different inhibitory potencies toward acetylcholinesterase activity (IC50 values of 1.04 x 10(-6) and 4.80 x 10(-4) mol/L, respectively) was performed. Wistar albino rats were orally treated with single doses (5 and 50 mg/kg) of both investigated compounds. The biochemical parameters of renal (serum urea and creatinine) and liver function (direct and total bilirubin, alanine transaminase, and aspartate aminotransferase) were determined after 24 h and 14 days. A histopathological analysis of liver tissue was carried out 14 days after the polyoxotungstate administration. Both applied doses of the investigated compounds did not induce statistically significant alterations of the renal function markers. However, the polyoxotungstate treatment caused an increase in the activities of serum alanine transaminase and aspartate aminotransferase in a time- and concentration -dependent manner, although statistically significant changes in bilirubin concentrations were not observed. Furthermore, the detected hepatotoxic effect was confirmed by histhopathological analysis that suggested some reversible liver tissue damage two weeks after the treatment, especially in the case of K6H [SiV3W9O40]-3H(2)O. Accordingly, the toxicity of these two polyoxotungstates with anti-acetylcholinesterase effect cannot be considered as a severe one, but their potential clinical application would require a more complex toxicological study.
T2  - Toxicology and Applied Pharmacology
T1  - Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity
VL  - 333
SP  - 68
EP  - 75
DO  - 10.1016/j.taap.2017.08.010
ER  - 
@article{
author = "Čolović, Mirjana B. and Medic, Branislava and Cetkovic, Mila and Kravić-Stevović, Tamara K. and Stojanovic, Marko and Ayass, Wassim W. and Mougharbel, Ali S. and Radenković, Miroslav and Prostran, Milica and Kortz, Ulrich and Krstić, Danijela Z.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1748",
abstract = "A toxicity evaluation of two Keggin-type heteropolytungstates, K-7[Ti2PW10O40].6H(2)O and K6H [SiV3W9O40].3H(2)O, with different inhibitory potencies toward acetylcholinesterase activity (IC50 values of 1.04 x 10(-6) and 4.80 x 10(-4) mol/L, respectively) was performed. Wistar albino rats were orally treated with single doses (5 and 50 mg/kg) of both investigated compounds. The biochemical parameters of renal (serum urea and creatinine) and liver function (direct and total bilirubin, alanine transaminase, and aspartate aminotransferase) were determined after 24 h and 14 days. A histopathological analysis of liver tissue was carried out 14 days after the polyoxotungstate administration. Both applied doses of the investigated compounds did not induce statistically significant alterations of the renal function markers. However, the polyoxotungstate treatment caused an increase in the activities of serum alanine transaminase and aspartate aminotransferase in a time- and concentration -dependent manner, although statistically significant changes in bilirubin concentrations were not observed. Furthermore, the detected hepatotoxic effect was confirmed by histhopathological analysis that suggested some reversible liver tissue damage two weeks after the treatment, especially in the case of K6H [SiV3W9O40]-3H(2)O. Accordingly, the toxicity of these two polyoxotungstates with anti-acetylcholinesterase effect cannot be considered as a severe one, but their potential clinical application would require a more complex toxicological study.",
journal = "Toxicology and Applied Pharmacology",
title = "Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity",
volume = "333",
pages = "68-75",
doi = "10.1016/j.taap.2017.08.010"
}
Čolović, M. B., Medic, B., Cetkovic, M., Kravić-Stevović, T. K., Stojanovic, M., Ayass, W. W., Mougharbel, A. S., Radenković, M., Prostran, M., Kortz, U.,& Krstić, D. Z. (2017). Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity.
Toxicology and Applied Pharmacology, 333, 68-75.
https://doi.org/10.1016/j.taap.2017.08.010
Čolović MB, Medic B, Cetkovic M, Kravić-Stevović TK, Stojanovic M, Ayass WW, Mougharbel AS, Radenković M, Prostran M, Kortz U, Krstić DZ. Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity. Toxicology and Applied Pharmacology. 2017;333:68-75
Čolović Mirjana B., Medic Branislava, Cetkovic Mila, Kravić-Stevović Tamara K., Stojanovic Marko, Ayass Wassim W., Mougharbel Ali S., Radenković Miroslav, Prostran Milica, Kortz Ulrich, Krstić Danijela Z., "Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity" Toxicology and Applied Pharmacology, 333 (2017):68-75,
https://doi.org/10.1016/j.taap.2017.08.010 .
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A comparison of Ar ion implantation and swift heavy Xe ion irradiation effects on immiscible AlN/TiN multilayered nanostructures

Milosavljević, Momir; Grce, Ana; Peruško, Davor; Stojanovic, Marko; Kovač, Janez; Drazic, Goran; Didyk, Alexander Yu.; Skuratov, Vladimir A.

(2012)

TY  - JOUR
AU  - Milosavljević, Momir
AU  - Grce, Ana
AU  - Peruško, Davor
AU  - Stojanovic, Marko
AU  - Kovač, Janez
AU  - Drazic, Goran
AU  - Didyk, Alexander Yu.
AU  - Skuratov, Vladimir A.
PY  - 2012
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4816
AB  - We have compared the effects of 200 keV Ar-40(1+) ion implantation and 166 MeV Xe-132(27+) ion irradiation on immiscible (AlN/TiN) x 5 multilayers grown on Si(1 0 0) wafers. The layers were deposited by reactive sputtering, individual layer thickness was similar to 22 nm (AlN) and similar to 32 nm (TiN), the stoichiometry Al:N similar to 45:55 and Ti:N similar to 50:50 at%. Argon was implanted to 4 x 10(16) ions cm(-2), and xenon to 5 x 10(14) ions cm(-2). The projected Ar range is around mid depth of the multilayered structure, while swift Xe ions are buried deep into the Si substrate. Upon irradiation the structures remain essentially stable and unmixed; although in both cases we observed detectable effects. The use of wide range of irradiation parameters (S-e/S-n = 1.2-1.4, dpa = 42-63 for Ar; and S-e/S-n = 249-258, dpa = 0.03-0.05 for Xe) enabled to distinguish between the contribution of nuclear and electronic stopping. In case of Ar implantation both atomic collisions and electronic excitations contribute to the induced structural modifications, and in case of Xe only electronic excitations. It was deduced that electronic excitations generate local heating which influences lateral grain growth within individual layers, but no elemental redistribution. On the other hand, atomic collisions facilitate a low level of Ti migration into the under-stoichiometric AlN layers, in the vicinity of the implanted Ar ion range. Energy transfer and temperature distribution were evaluated and compared to the effects produced in the structures. The presented results can be interesting towards developing radiation tolerant materials. (C) 2012 Elsevier B.V. All rights reserved.
T2  - Materials Chemistry and Physics
T1  - A comparison of Ar ion implantation and swift heavy Xe ion irradiation effects on immiscible AlN/TiN multilayered nanostructures
VL  - 133
IS  - 2-3
SP  - 884
EP  - 892
DO  - 10.1016/j.matchemphys.2012.01.112
ER  - 
@article{
author = "Milosavljević, Momir and Grce, Ana and Peruško, Davor and Stojanovic, Marko and Kovač, Janez and Drazic, Goran and Didyk, Alexander Yu. and Skuratov, Vladimir A.",
year = "2012",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/4816",
abstract = "We have compared the effects of 200 keV Ar-40(1+) ion implantation and 166 MeV Xe-132(27+) ion irradiation on immiscible (AlN/TiN) x 5 multilayers grown on Si(1 0 0) wafers. The layers were deposited by reactive sputtering, individual layer thickness was similar to 22 nm (AlN) and similar to 32 nm (TiN), the stoichiometry Al:N similar to 45:55 and Ti:N similar to 50:50 at%. Argon was implanted to 4 x 10(16) ions cm(-2), and xenon to 5 x 10(14) ions cm(-2). The projected Ar range is around mid depth of the multilayered structure, while swift Xe ions are buried deep into the Si substrate. Upon irradiation the structures remain essentially stable and unmixed; although in both cases we observed detectable effects. The use of wide range of irradiation parameters (S-e/S-n = 1.2-1.4, dpa = 42-63 for Ar; and S-e/S-n = 249-258, dpa = 0.03-0.05 for Xe) enabled to distinguish between the contribution of nuclear and electronic stopping. In case of Ar implantation both atomic collisions and electronic excitations contribute to the induced structural modifications, and in case of Xe only electronic excitations. It was deduced that electronic excitations generate local heating which influences lateral grain growth within individual layers, but no elemental redistribution. On the other hand, atomic collisions facilitate a low level of Ti migration into the under-stoichiometric AlN layers, in the vicinity of the implanted Ar ion range. Energy transfer and temperature distribution were evaluated and compared to the effects produced in the structures. The presented results can be interesting towards developing radiation tolerant materials. (C) 2012 Elsevier B.V. All rights reserved.",
journal = "Materials Chemistry and Physics",
title = "A comparison of Ar ion implantation and swift heavy Xe ion irradiation effects on immiscible AlN/TiN multilayered nanostructures",
volume = "133",
number = "2-3",
pages = "884-892",
doi = "10.1016/j.matchemphys.2012.01.112"
}
Milosavljević, M., Grce, A., Peruško, D., Stojanovic, M., Kovač, J., Drazic, G., Didyk, A. Yu.,& Skuratov, V. A. (2012). A comparison of Ar ion implantation and swift heavy Xe ion irradiation effects on immiscible AlN/TiN multilayered nanostructures.
Materials Chemistry and Physics, 133(2-3), 884-892.
https://doi.org/10.1016/j.matchemphys.2012.01.112
Milosavljević M, Grce A, Peruško D, Stojanovic M, Kovač J, Drazic G, Didyk AY, Skuratov VA. A comparison of Ar ion implantation and swift heavy Xe ion irradiation effects on immiscible AlN/TiN multilayered nanostructures. Materials Chemistry and Physics. 2012;133(2-3):884-892
Milosavljević Momir, Grce Ana, Peruško Davor, Stojanovic Marko, Kovač Janez, Drazic Goran, Didyk Alexander Yu., Skuratov Vladimir A., "A comparison of Ar ion implantation and swift heavy Xe ion irradiation effects on immiscible AlN/TiN multilayered nanostructures" Materials Chemistry and Physics, 133, no. 2-3 (2012):884-892,
https://doi.org/10.1016/j.matchemphys.2012.01.112 .
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