Krstić, Danijela Z.

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Authority KeyName Variants
7ba87a94-a274-4997-906e-2075d4cc01c4
  • Krstić, Danijela Z. (51)
Projects
Studies of enzyme interactions with toxic and pharmacologically active molecules The effects of homocysteine and homocysteine-related compounds on cardiovascular system: role of gaseous transmitters No, H2S and CO
Electroconducting and redox-active polymers and oligomers: synthesis, structure, properties and applications The development of animal models of epilepsy and testing convulsive and anticonvulsive substances
Beneficentia Stiftung (Vaduz), ITT (Istituto Toscano Tumori), Fondazione Cassa Risparmio Firenze (CRF), AIRC [IG-16049], AIRC-FIRC (Fondazione Italiana per la Ricerca sul Cancro) [18044] Campus France for a PHC support ["Pavle Savić" 23643QC]
Campus France for a Prestige grant Chinese Science of Council
CSC, Wuhan Applied Basic Research Program [2014010101010020] The membranes as sites of interaction between the intracellular and apoplastic environments: studies of the bioenergetics and signaling using biophysical and biochemical techniques.
Basic and Clinical Pharmacological research of mechanisms of action and drug interactions in nervous and cardiovascular system Significance of early diagnosis of obstructive sleep apnea syndrome in professional drivers operating motor vehicles
Hypothalamic and medullary functional genomics in stress-induced hypertension Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia
Istraživanje mehanizma interakcija biološki aktivnih jedinjenja sa biomolekulima Ministry for Science, Technology, and Environment Protection of Serbia [145029B, 145014B]
Ministry of Science and Environmental Protection of the Republic of Serbia [142025] Ministry of Science and Technological Development of the Republic of Serbia [142051]
Ministry of Science and Technological Development of the Republic of Serbia [142051], Ministry of Higher Education, Science and Technology of the Republic of Slovenia National Natural Science Foundation of China [21225103]
National Natural Science Foundation of China [21471087] National Natural Science Foundation of China [21631007]
Republic of Serbia [142051] Serbian Ministry of Science [142051]

Author's Bibliography

Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays

Bošnjaković-Pavlović, Nada; Xu, Xiao; Krstić, Danijela Z.; Gillet, Jean-Michel; Wei, Yongge; Wu, Pingfan; Čolović, Mirjana B.; Spasojević-de Biré, Anne

(2019)

TY  - JOUR
AU  - Bošnjaković-Pavlović, Nada
AU  - Xu, Xiao
AU  - Krstić, Danijela Z.
AU  - Gillet, Jean-Michel
AU  - Wei, Yongge
AU  - Wu, Pingfan
AU  - Čolović, Mirjana B.
AU  - Spasojević-de Biré, Anne
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0162013418306998
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8355
AB  - The influence of three functionalized hexavanadates (V6): Na2 [V6O13{(OCH2)3CCH3}2], [H2]2 [V6O13{(OCH2)3CCH2OCOCH2CH3}2] and [(C4H9)4N]2 [V6O13{(OCH2)3CCH2OOC(CH3)2-COOH}2 on Na+/K+-ATPase activity, was investigated in vitro. Including compounds already tested by Xu et al. (Journal of Inorganic Biochemistry 161 (2016) 27–36), all functionalized hexavanadates inhibit the activity of Na+/K+-ATPase in a dose-dependent manner but with different inhibitory potencies. Na2 [V6O13{(OCH2)3CCH3}2] was found to have the best inhibition properties - showing 50% inhibition IC50 = 5.50 × 10−5 M, while [(C4H9)4N]2 [V6O13{(OCH2)3CCH2OOC(CH3)2-COOH}2] showed the lowest inhibitory power, IC50 = 1.31 × 10−4 M. In order to understand the bioactivity of functionalized hexavanadates series, we have also used a combined theoretical approach: determination of electrostatic potential from ab initio theoretical calculations and computation of the molecular interaction field (MIF) surface. © 2019
T2  - Journal of Inorganic Biochemistry
T1  - Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays
VL  - 198
SP  - 110720
DO  - 10.1016/j.jinorgbio.2019.110720
ER  - 
@article{
author = "Bošnjaković-Pavlović, Nada and Xu, Xiao and Krstić, Danijela Z. and Gillet, Jean-Michel and Wei, Yongge and Wu, Pingfan and Čolović, Mirjana B. and Spasojević-de Biré, Anne",
year = "2019",
url = "https://linkinghub.elsevier.com/retrieve/pii/S0162013418306998, http://vinar.vin.bg.ac.rs/handle/123456789/8355",
abstract = "The influence of three functionalized hexavanadates (V6): Na2 [V6O13{(OCH2)3CCH3}2], [H2]2 [V6O13{(OCH2)3CCH2OCOCH2CH3}2] and [(C4H9)4N]2 [V6O13{(OCH2)3CCH2OOC(CH3)2-COOH}2 on Na+/K+-ATPase activity, was investigated in vitro. Including compounds already tested by Xu et al. (Journal of Inorganic Biochemistry 161 (2016) 27–36), all functionalized hexavanadates inhibit the activity of Na+/K+-ATPase in a dose-dependent manner but with different inhibitory potencies. Na2 [V6O13{(OCH2)3CCH3}2] was found to have the best inhibition properties - showing 50% inhibition IC50 = 5.50 × 10−5 M, while [(C4H9)4N]2 [V6O13{(OCH2)3CCH2OOC(CH3)2-COOH}2] showed the lowest inhibitory power, IC50 = 1.31 × 10−4 M. In order to understand the bioactivity of functionalized hexavanadates series, we have also used a combined theoretical approach: determination of electrostatic potential from ab initio theoretical calculations and computation of the molecular interaction field (MIF) surface. © 2019",
journal = "Journal of Inorganic Biochemistry",
title = "Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays",
volume = "198",
pages = "110720",
doi = "10.1016/j.jinorgbio.2019.110720"
}
Bošnjaković-Pavlović, N., Xu, X., Krstić, D. Z., Gillet, J., Wei, Y., Wu, P., Čolović, M. B.,& Spasojević-de Biré, A. (2019). Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays.
Journal of Inorganic Biochemistry, 198, 110720.
https://doi.org/10.1016/j.jinorgbio.2019.110720
Bošnjaković-Pavlović N, Xu X, Krstić DZ, Gillet J, Wei Y, Wu P, Čolović MB, Spasojević-de Biré A. Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays. Journal of Inorganic Biochemistry. 2019;198:110720
Bošnjaković-Pavlović Nada, Xu Xiao, Krstić Danijela Z., Gillet Jean-Michel, Wei Yongge, Wu Pingfan, Čolović Mirjana B., Spasojević-de Biré Anne, "Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays" Journal of Inorganic Biochemistry, 198 (2019):110720,
https://doi.org/10.1016/j.jinorgbio.2019.110720 .
3
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Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters

Jakovljević-Uzelac, Jovana; Stanić, Marina; Krstić, Danijela Z.; Čolović, Mirjana B.; Đurić, Dragan M.

(2018)

TY  - JOUR
AU  - Jakovljević-Uzelac, Jovana
AU  - Stanić, Marina
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Đurić, Dragan M.
PY  - 2018
UR  - http://link.springer.com/10.1007/s11010-017-3238-z
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7788
AB  - The objective of this study was to investigate in vitro effects of 10 A mu M dl-homocysteine (dl-Hcy), dl-homocysteine thiolactone-hydrochloride (dl-Hcy TLHC), and l-homocysteine thiolactone-hydrochloride (l-Hcy TLHC) on the oxygen consumption of rat heart tissue homogenate, as well as the involvement of the gasotransmitters NO, H2S and CO in the effects of the most toxic homocysteine compound, dl-Hcy TLHC. The possible contribution of the gasotransmitters in these effects was estimated by using the appropriate inhibitors of their synthesis (N (omega)-nitro-l-arginine methyl ester (l-NAME), dl-propargylglycine (dl-PAG), and zinc protoporphyrin IX (ZnPPR IX), respectively). The oxygen consumption of rat heart tissue homogenate was measured by Clark/type oxygen electrode in the absence and presence of the investigated compounds. All three homocysteine-based compounds caused a similar decrease in the oxygen consumption rate compared to control: 15.19 +/- 4.01%, 12.42 +/- 1.01%, and 16.43 +/- 4.52% for dl-Hcy, dl-Hcy TLHC, or l-Hcy TLHC, respectively. All applied inhibitors of gasotransmitter synthesis also decreased the oxygen consumption rate of tissue homogenate related to control: 13.53 +/- 1.35% for l-NAME (30 A mu M), 5.32 +/- 1.23% for dl-PAG (10 A mu M), and 5.56 +/- 1.39% for ZnPPR IX (10 A mu M). Simultaneous effect of l-NAME (30 A mu M) or ZnPPR IX (10 A mu M) with dl-Hcy TLHC (10 A mu M) caused a larger decrease of oxygen consumption compared to each of the substances individually. However, when dl-PAG (10 A mu M) was applied together with dl-Hcy TLHC (10 A mu M), it attenuated the effect of dl-Hcy TLHC from 12.42 +/- 1.01 to 9.22 +/- 1.58%. In conclusion, cardiotoxicity induced by Hcy-related compounds, which was shown in our previous research, could result from the inhibition of the oxygen consumption, and might be mediated by the certain gasotransmitters.
T2  - Molecular and Cellular Biochemistry
T1  - Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters
VL  - 444
IS  - 1-2
SP  - 143
EP  - 148
DO  - 10.1007/s11010-017-3238-z
ER  - 
@article{
author = "Jakovljević-Uzelac, Jovana and Stanić, Marina and Krstić, Danijela Z. and Čolović, Mirjana B. and Đurić, Dragan M.",
year = "2018",
url = "http://link.springer.com/10.1007/s11010-017-3238-z, http://vinar.vin.bg.ac.rs/handle/123456789/7788",
abstract = "The objective of this study was to investigate in vitro effects of 10 A mu M dl-homocysteine (dl-Hcy), dl-homocysteine thiolactone-hydrochloride (dl-Hcy TLHC), and l-homocysteine thiolactone-hydrochloride (l-Hcy TLHC) on the oxygen consumption of rat heart tissue homogenate, as well as the involvement of the gasotransmitters NO, H2S and CO in the effects of the most toxic homocysteine compound, dl-Hcy TLHC. The possible contribution of the gasotransmitters in these effects was estimated by using the appropriate inhibitors of their synthesis (N (omega)-nitro-l-arginine methyl ester (l-NAME), dl-propargylglycine (dl-PAG), and zinc protoporphyrin IX (ZnPPR IX), respectively). The oxygen consumption of rat heart tissue homogenate was measured by Clark/type oxygen electrode in the absence and presence of the investigated compounds. All three homocysteine-based compounds caused a similar decrease in the oxygen consumption rate compared to control: 15.19 +/- 4.01%, 12.42 +/- 1.01%, and 16.43 +/- 4.52% for dl-Hcy, dl-Hcy TLHC, or l-Hcy TLHC, respectively. All applied inhibitors of gasotransmitter synthesis also decreased the oxygen consumption rate of tissue homogenate related to control: 13.53 +/- 1.35% for l-NAME (30 A mu M), 5.32 +/- 1.23% for dl-PAG (10 A mu M), and 5.56 +/- 1.39% for ZnPPR IX (10 A mu M). Simultaneous effect of l-NAME (30 A mu M) or ZnPPR IX (10 A mu M) with dl-Hcy TLHC (10 A mu M) caused a larger decrease of oxygen consumption compared to each of the substances individually. However, when dl-PAG (10 A mu M) was applied together with dl-Hcy TLHC (10 A mu M), it attenuated the effect of dl-Hcy TLHC from 12.42 +/- 1.01 to 9.22 +/- 1.58%. In conclusion, cardiotoxicity induced by Hcy-related compounds, which was shown in our previous research, could result from the inhibition of the oxygen consumption, and might be mediated by the certain gasotransmitters.",
journal = "Molecular and Cellular Biochemistry",
title = "Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters",
volume = "444",
number = "1-2",
pages = "143-148",
doi = "10.1007/s11010-017-3238-z"
}
Jakovljević-Uzelac, J., Stanić, M., Krstić, D. Z., Čolović, M. B.,& Đurić, D. M. (2018). Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters.
Molecular and Cellular Biochemistry, 444(1-2), 143-148.
https://doi.org/10.1007/s11010-017-3238-z
Jakovljević-Uzelac J, Stanić M, Krstić DZ, Čolović MB, Đurić DM. Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters. Molecular and Cellular Biochemistry. 2018;444(1-2):143-148
Jakovljević-Uzelac Jovana, Stanić Marina, Krstić Danijela Z., Čolović Mirjana B., Đurić Dragan M., "Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters" Molecular and Cellular Biochemistry, 444, no. 1-2 (2018):143-148,
https://doi.org/10.1007/s11010-017-3238-z .
6
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3

Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue

Stojanović, Marija; Todorović, Dajana D.; Šćepanović, Ljiljana; Mitrović, Dušan M.; Borozan, Sunčica Z.; Dragutinović, Vesna V.; Labudović-Borović, Milica; Krstić, Danijela Z.; Čolović, Mirjana B.; Đurić, Dragan M.

(2018)

TY  - JOUR
AU  - Stojanović, Marija
AU  - Todorović, Dajana D.
AU  - Šćepanović, Ljiljana
AU  - Mitrović, Dušan M.
AU  - Borozan, Sunčica Z.
AU  - Dragutinović, Vesna V.
AU  - Labudović-Borović, Milica
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Đurić, Dragan M.
PY  - 2018
UR  - http://link.springer.com/10.1007/s11010-018-3311-2
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8060
AB  - The aim of this study was to assess the effects of l-cysteine (Cys) (7 mg/kg) and N-acetyl-l-cysteine (NAC) (50 mg/kg) in the rat liver caused by subchronic i.p. application of methionine (Met) (0.8 mmol/kg) during 21 days. Malondialdehyde (MDA) concentration, glutathione content (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and acetylcholinesterase (AchE) activities were determined in the liver tissue and activities of liver enzymes (AST, ALT, ALP, and GGT) and concentrations of total proteins and albumin were determinated in plasma/serum. Catalase, superoxide dismutase, and acetylcholinesterase activities were increased by Cys and NAC. Met caused periportal mononuclear infiltration and rare focal necrosis of hepatocytes. In Cys- and NAC-supplemented groups, intracellular edema and microvesicular fatty changes without necrosis were noticed. We observed decrease of AST, ALT, and ALP activity in the methionine-treated group. Our results indicate that Cys and NAC application can increase activity of antioxidative enzymes and prevent intensive histological changes in liver in condition of subchronic methionine exposure.
T2  - Molecular and Cellular Biochemistry
T1  - Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue
VL  - 448
IS  - 1-2
SP  - 43
EP  - 50
DO  - 10.1007/s11010-018-3311-2
ER  - 
@article{
author = "Stojanović, Marija and Todorović, Dajana D. and Šćepanović, Ljiljana and Mitrović, Dušan M. and Borozan, Sunčica Z. and Dragutinović, Vesna V. and Labudović-Borović, Milica and Krstić, Danijela Z. and Čolović, Mirjana B. and Đurić, Dragan M.",
year = "2018",
url = "http://link.springer.com/10.1007/s11010-018-3311-2, http://vinar.vin.bg.ac.rs/handle/123456789/8060",
abstract = "The aim of this study was to assess the effects of l-cysteine (Cys) (7 mg/kg) and N-acetyl-l-cysteine (NAC) (50 mg/kg) in the rat liver caused by subchronic i.p. application of methionine (Met) (0.8 mmol/kg) during 21 days. Malondialdehyde (MDA) concentration, glutathione content (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and acetylcholinesterase (AchE) activities were determined in the liver tissue and activities of liver enzymes (AST, ALT, ALP, and GGT) and concentrations of total proteins and albumin were determinated in plasma/serum. Catalase, superoxide dismutase, and acetylcholinesterase activities were increased by Cys and NAC. Met caused periportal mononuclear infiltration and rare focal necrosis of hepatocytes. In Cys- and NAC-supplemented groups, intracellular edema and microvesicular fatty changes without necrosis were noticed. We observed decrease of AST, ALT, and ALP activity in the methionine-treated group. Our results indicate that Cys and NAC application can increase activity of antioxidative enzymes and prevent intensive histological changes in liver in condition of subchronic methionine exposure.",
journal = "Molecular and Cellular Biochemistry",
title = "Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue",
volume = "448",
number = "1-2",
pages = "43-50",
doi = "10.1007/s11010-018-3311-2"
}
Stojanović, M., Todorović, D. D., Šćepanović, L., Mitrović, D. M., Borozan, S. Z., Dragutinović, V. V., Labudović-Borović, M., Krstić, D. Z., Čolović, M. B.,& Đurić, D. M. (2018). Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue.
Molecular and Cellular Biochemistry, 448(1-2), 43-50.
https://doi.org/10.1007/s11010-018-3311-2
Stojanović M, Todorović DD, Šćepanović L, Mitrović DM, Borozan SZ, Dragutinović VV, Labudović-Borović M, Krstić DZ, Čolović MB, Đurić DM. Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue. Molecular and Cellular Biochemistry. 2018;448(1-2):43-50
Stojanović Marija, Todorović Dajana D., Šćepanović Ljiljana, Mitrović Dušan M., Borozan Sunčica Z., Dragutinović Vesna V., Labudović-Borović Milica, Krstić Danijela Z., Čolović Mirjana B., Đurić Dragan M., "Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue" Molecular and Cellular Biochemistry, 448, no. 1-2 (2018):43-50,
https://doi.org/10.1007/s11010-018-3311-2 .
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7
7

The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat

Kornjača, Duško; Živković, Vladimir I.; Krstić, Danijela Z.; Čolović, Mirjana B.; Đurić, Marko; Stanković, Sanja; Mutavdžin, Slavica; Jakovljević, Vladimir Lj.; Đurić, Dragan M.

(2018)

TY  - JOUR
AU  - Kornjača, Duško
AU  - Živković, Vladimir I.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Đurić, Marko
AU  - Stanković, Sanja
AU  - Mutavdžin, Slavica
AU  - Jakovljević, Vladimir Lj.
AU  - Đurić, Dragan M.
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700041K
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7714
AB  - The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.
T2  - Archives of Biological Sciences
T1  - The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat
VL  - 70
IS  - 2
SP  - 241
EP  - 248
DO  - 10.2298/ABS170731041K
ER  - 
@article{
author = "Kornjača, Duško and Živković, Vladimir I. and Krstić, Danijela Z. and Čolović, Mirjana B. and Đurić, Marko and Stanković, Sanja and Mutavdžin, Slavica and Jakovljević, Vladimir Lj. and Đurić, Dragan M.",
year = "2018",
url = "http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700041K, http://vinar.vin.bg.ac.rs/handle/123456789/7714",
abstract = "The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.",
journal = "Archives of Biological Sciences",
title = "The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat",
volume = "70",
number = "2",
pages = "241-248",
doi = "10.2298/ABS170731041K"
}
Kornjača, D., Živković, V. I., Krstić, D. Z., Čolović, M. B., Đurić, M., Stanković, S., Mutavdžin, S., Jakovljević, V. Lj.,& Đurić, D. M. (2018). The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat.
Archives of Biological Sciences, 70(2), 241-248.
https://doi.org/10.2298/ABS170731041K
Kornjača D, Živković VI, Krstić DZ, Čolović MB, Đurić M, Stanković S, Mutavdžin S, Jakovljević VL, Đurić DM. The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat. Archives of Biological Sciences. 2018;70(2):241-248
Kornjača Duško, Živković Vladimir I., Krstić Danijela Z., Čolović Mirjana B., Đurić Marko, Stanković Sanja, Mutavdžin Slavica, Jakovljević Vladimir Lj., Đurić Dragan M., "The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat" Archives of Biological Sciences, 70, no. 2 (2018):241-248,
https://doi.org/10.2298/ABS170731041K .
1
1

The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood

Đurić, Aleksandar; Čolović, Mirjana B.; Krstić, Danijela Z.; Obrenović, Radmila; Micovic, Z; Đurić, Marija; Đurić, Dragan M.

(2018)

TY  - CONF
AU  - Đurić, Aleksandar
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Obrenović, Radmila
AU  - Micovic, Z
AU  - Đurić, Marija
AU  - Đurić, Dragan M.
PY  - 2018
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0021915018309547
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7954
C3  - Atherosclerosis
T1  - The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood
VL  - 275
SP  - e206
EP  - e207
DO  - 10.1016/j.atherosclerosis.2018.06.642
ER  - 
@conference{
author = "Đurić, Aleksandar and Čolović, Mirjana B. and Krstić, Danijela Z. and Obrenović, Radmila and Micovic, Z and Đurić, Marija and Đurić, Dragan M.",
year = "2018",
url = "https://linkinghub.elsevier.com/retrieve/pii/S0021915018309547, http://vinar.vin.bg.ac.rs/handle/123456789/7954",
journal = "Atherosclerosis",
title = "The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood",
volume = "275",
pages = "e206-e207",
doi = "10.1016/j.atherosclerosis.2018.06.642"
}
Đurić, A., Čolović, M. B., Krstić, D. Z., Obrenović, R., Micovic, Z., Đurić, M.,& Đurić, D. M. (2018). The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood.
Atherosclerosis, 275, e206-e207.
https://doi.org/10.1016/j.atherosclerosis.2018.06.642
Đurić A, Čolović MB, Krstić DZ, Obrenović R, Micovic Z, Đurić M, Đurić DM. The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood. Atherosclerosis. 2018;275:e206-e207
Đurić Aleksandar, Čolović Mirjana B., Krstić Danijela Z., Obrenović Radmila, Micovic Z, Đurić Marija, Đurić Dragan M., "The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood" Atherosclerosis, 275 (2018):e206-e207,
https://doi.org/10.1016/j.atherosclerosis.2018.06.642 .

Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field

Dinčić, Marko; Krstić, Danijela Z.; Čolović, Mirjana B.; Nešović Ostojić, Jelena; Kovačević, Sanjin; De Luka, Silvio R.; Đorđević, Drago M.; Ćirković, Saša; Brkić, Predrag; Todorović, Jasna

(2018)

TY  - JOUR
AU  - Dinčić, Marko
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Nešović Ostojić, Jelena
AU  - Kovačević, Sanjin
AU  - De Luka, Silvio R.
AU  - Đorđević, Drago M.
AU  - Ćirković, Saša
AU  - Brkić, Predrag
AU  - Todorović, Jasna
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1518611
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7957
AB  - Purpose: It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF. Material and methods: Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up and Down group - exposed to upward and downward oriented SMF, respectively, and Control group. After 50 days, the rats were sacrificed, and synaptosomes were isolated from the whole rat brain and used for testing the enzyme activities and oxidative stress parameters. Results: Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (MDA) level in both exposed groups, compared to control values. The significant decrease in synaptosomal catalase activity (1.48 ± 0.17 U/mg protein) induced by exposure to the downward oriented field, compared to those obtained for Control group (2.60 ± 0.29 U/mg protein), and Up group (2.72 ± 0.21 U/mg protein). Conclusions: It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance. © 2018, Copyright © 2018 Taylor & Francis Group, LLC.
T2  - International Journal of Radiation Biology
T1  - Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field
VL  - 94
IS  - 11
SP  - 1062
EP  - 1071
DO  - 10.1080/09553002.2018.1518611
ER  - 
@article{
author = "Dinčić, Marko and Krstić, Danijela Z. and Čolović, Mirjana B. and Nešović Ostojić, Jelena and Kovačević, Sanjin and De Luka, Silvio R. and Đorđević, Drago M. and Ćirković, Saša and Brkić, Predrag and Todorović, Jasna",
year = "2018",
url = "https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1518611, http://vinar.vin.bg.ac.rs/handle/123456789/7957",
abstract = "Purpose: It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF. Material and methods: Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up and Down group - exposed to upward and downward oriented SMF, respectively, and Control group. After 50 days, the rats were sacrificed, and synaptosomes were isolated from the whole rat brain and used for testing the enzyme activities and oxidative stress parameters. Results: Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (MDA) level in both exposed groups, compared to control values. The significant decrease in synaptosomal catalase activity (1.48 ± 0.17 U/mg protein) induced by exposure to the downward oriented field, compared to those obtained for Control group (2.60 ± 0.29 U/mg protein), and Up group (2.72 ± 0.21 U/mg protein). Conclusions: It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance. © 2018, Copyright © 2018 Taylor & Francis Group, LLC.",
journal = "International Journal of Radiation Biology",
title = "Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field",
volume = "94",
number = "11",
pages = "1062-1071",
doi = "10.1080/09553002.2018.1518611"
}
Dinčić, M., Krstić, D. Z., Čolović, M. B., Nešović Ostojić, J., Kovačević, S., De Luka, S. R., Đorđević, D. M., Ćirković, S., Brkić, P.,& Todorović, J. (2018). Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field.
International Journal of Radiation Biology, 94(11), 1062-1071.
https://doi.org/10.1080/09553002.2018.1518611
Dinčić M, Krstić DZ, Čolović MB, Nešović Ostojić J, Kovačević S, De Luka SR, Đorđević DM, Ćirković S, Brkić P, Todorović J. Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field. International Journal of Radiation Biology. 2018;94(11):1062-1071
Dinčić Marko, Krstić Danijela Z., Čolović Mirjana B., Nešović Ostojić Jelena, Kovačević Sanjin, De Luka Silvio R., Đorđević Drago M., Ćirković Saša, Brkić Predrag, Todorović Jasna, "Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field" International Journal of Radiation Biology, 94, no. 11 (2018):1062-1071,
https://doi.org/10.1080/09553002.2018.1518611 .
1
2
1
1

Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals

Čolović, Mirjana B.; Vasić, Vesna M.; Đurić, Dragan M.; Krstić, Danijela Z.

(2018)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Vasić, Vesna M.
AU  - Đurić, Dragan M.
AU  - Krstić, Danijela Z.
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1926
AB  - Background: Sulphur is an abundant element in biological systems, which plays an important role in processes essential for life as a constituent of proteins, vitamins and other crucial biomolecules. The major source of sulphur for humans is plants being able to use inorganic sulphur in the purpose of sulphur-containing amino acids synthesis. Sulphur-containing amino acids include methionine, cysteine, homocysteine, and taurine. Methionine and cysteine are classified as proteinogenic, canonic amino acids incorporated in protein structure. Sulphur amino acids are involved in the synthesis of intracellular antioxidants such as glutathione and N-acetyl cysteine. Moreover, naturally occurring sulphur-containing ligands are effective and safe detoxifying agents, often used in order to prevent toxic metal ions effects and their accumulation in human body. Methods: Literature search for peer-reviewed articles was performed using PubMed and Scopus databases, and utilizing appropriate keywords. Results: This review is focused on sulphur-containing amino acids - methionine, cysteine, taurine, and their derivatives - glutathione and N-acetylcysteine, and their defense effects as antioxidant agents against free radicals. Additionally, the protective effects of sulphur-containing ligands against the toxic effects of heavy and transition metal ions, and their reactivation role towards the enzyme inhibition are described. Conclusion: Sulphur-containing amino acids represent a powerful part of cell antioxidant system. Thus, they are essential in the maintenance of normal cellular functions and health. In addition to their worthy antioxidant action, sulphur-containing amino acids may offer a chelating site for heavy metals. Accordingly, they may be supplemented during chelating therapy, providing beneficial effects in eliminating toxic metals.
T2  - Current Medicinal Chemistry
T1  - Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals
VL  - 25
IS  - 3
SP  - 324
EP  - 335
DO  - 10.2174/0929867324666170609075434
ER  - 
@article{
author = "Čolović, Mirjana B. and Vasić, Vesna M. and Đurić, Dragan M. and Krstić, Danijela Z.",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1926",
abstract = "Background: Sulphur is an abundant element in biological systems, which plays an important role in processes essential for life as a constituent of proteins, vitamins and other crucial biomolecules. The major source of sulphur for humans is plants being able to use inorganic sulphur in the purpose of sulphur-containing amino acids synthesis. Sulphur-containing amino acids include methionine, cysteine, homocysteine, and taurine. Methionine and cysteine are classified as proteinogenic, canonic amino acids incorporated in protein structure. Sulphur amino acids are involved in the synthesis of intracellular antioxidants such as glutathione and N-acetyl cysteine. Moreover, naturally occurring sulphur-containing ligands are effective and safe detoxifying agents, often used in order to prevent toxic metal ions effects and their accumulation in human body. Methods: Literature search for peer-reviewed articles was performed using PubMed and Scopus databases, and utilizing appropriate keywords. Results: This review is focused on sulphur-containing amino acids - methionine, cysteine, taurine, and their derivatives - glutathione and N-acetylcysteine, and their defense effects as antioxidant agents against free radicals. Additionally, the protective effects of sulphur-containing ligands against the toxic effects of heavy and transition metal ions, and their reactivation role towards the enzyme inhibition are described. Conclusion: Sulphur-containing amino acids represent a powerful part of cell antioxidant system. Thus, they are essential in the maintenance of normal cellular functions and health. In addition to their worthy antioxidant action, sulphur-containing amino acids may offer a chelating site for heavy metals. Accordingly, they may be supplemented during chelating therapy, providing beneficial effects in eliminating toxic metals.",
journal = "Current Medicinal Chemistry",
title = "Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals",
volume = "25",
number = "3",
pages = "324-335",
doi = "10.2174/0929867324666170609075434"
}
Čolović, M. B., Vasić, V. M., Đurić, D. M.,& Krstić, D. Z. (2018). Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals.
Current Medicinal Chemistry, 25(3), 324-335.
https://doi.org/10.2174/0929867324666170609075434
Čolović MB, Vasić VM, Đurić DM, Krstić DZ. Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals. Current Medicinal Chemistry. 2018;25(3):324-335
Čolović Mirjana B., Vasić Vesna M., Đurić Dragan M., Krstić Danijela Z., "Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals" Current Medicinal Chemistry, 25, no. 3 (2018):324-335,
https://doi.org/10.2174/0929867324666170609075434 .
28
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24

The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach

Bondžić, Aleksandra; Čolović, Mirjana B.; Janjić, Goran V.; Zarić, Božidarka; Petrović, Sandra; Krstić, Danijela Z.; Marzo, Tiziano; Messori, Luigi; Vasić, Vesna M.

(2017)

TY  - JOUR
AU  - Bondžić, Aleksandra
AU  - Čolović, Mirjana B.
AU  - Janjić, Goran V.
AU  - Zarić, Božidarka
AU  - Petrović, Sandra
AU  - Krstić, Danijela Z.
AU  - Marzo, Tiziano
AU  - Messori, Luigi
AU  - Vasić, Vesna M.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1648
AB  - The in vitro effects of oxo-bridged binuclear gold(III) complexes, i.e., [(bipy2Me)(2)Au-2(mu-O)(2)][PF6](2) (Auoxo6), Au-2[(bipydmb-H)(2)(mu-O)][PF6] (Au(2)bipyC) and [Au-2(phen(2Me))(2)(mu-O)(2)](PF6)(2) (Au(2)phen) on Na/K-ATPase, purified from the porcine cerebral cortex, were investigated. All three studied gold complexes inhibited the enzyme activity in a concentration-dependent manner achieving IC50 values in the low micromolar range. Kinetic analysis suggested an uncompetitive mode of inhibition for Auoxo6 and Au(2)bipyC, and a mixed type one for Au(2)phen. Docking studies indicated that the inhibitory actions of all tested complexes are related to E2-P enzyme conformation binding to ion channel and intracellular part between N and P sub-domain. In addition, Au(2)phen was able to inhibit the enzyme by interacting with its extracellular part as well. Toxic effects of the gold(III) complexes were evaluated in vitro by following lactate dehydrogenase activity in rat brain synaptosomes and incidence of micronuclei and cytokinesis-block proliferation index in cultivated human lymphocytes. All investigated complexes turned out to induce cytogenetic damage consisting of a significant decrease in cell proliferation and an increase in micronuclei in a dose-dependent manner. On the other hand, lactate dehydrogenase activity, an indicator of membrane integrity/viability, was not affected by Auoxo6 and Au(2)bipyC, while Au(2)phen slightly modified its activity.
T2  - Journal of Biological Inorganic Chemistry
T1  - The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach
VL  - 22
IS  - 6
SP  - 819
EP  - 832
DO  - 10.1007/s00775-017-1460-5
ER  - 
@article{
author = "Bondžić, Aleksandra and Čolović, Mirjana B. and Janjić, Goran V. and Zarić, Božidarka and Petrović, Sandra and Krstić, Danijela Z. and Marzo, Tiziano and Messori, Luigi and Vasić, Vesna M.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1648",
abstract = "The in vitro effects of oxo-bridged binuclear gold(III) complexes, i.e., [(bipy2Me)(2)Au-2(mu-O)(2)][PF6](2) (Auoxo6), Au-2[(bipydmb-H)(2)(mu-O)][PF6] (Au(2)bipyC) and [Au-2(phen(2Me))(2)(mu-O)(2)](PF6)(2) (Au(2)phen) on Na/K-ATPase, purified from the porcine cerebral cortex, were investigated. All three studied gold complexes inhibited the enzyme activity in a concentration-dependent manner achieving IC50 values in the low micromolar range. Kinetic analysis suggested an uncompetitive mode of inhibition for Auoxo6 and Au(2)bipyC, and a mixed type one for Au(2)phen. Docking studies indicated that the inhibitory actions of all tested complexes are related to E2-P enzyme conformation binding to ion channel and intracellular part between N and P sub-domain. In addition, Au(2)phen was able to inhibit the enzyme by interacting with its extracellular part as well. Toxic effects of the gold(III) complexes were evaluated in vitro by following lactate dehydrogenase activity in rat brain synaptosomes and incidence of micronuclei and cytokinesis-block proliferation index in cultivated human lymphocytes. All investigated complexes turned out to induce cytogenetic damage consisting of a significant decrease in cell proliferation and an increase in micronuclei in a dose-dependent manner. On the other hand, lactate dehydrogenase activity, an indicator of membrane integrity/viability, was not affected by Auoxo6 and Au(2)bipyC, while Au(2)phen slightly modified its activity.",
journal = "Journal of Biological Inorganic Chemistry",
title = "The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach",
volume = "22",
number = "6",
pages = "819-832",
doi = "10.1007/s00775-017-1460-5"
}
Bondžić, A., Čolović, M. B., Janjić, G. V., Zarić, B., Petrović, S., Krstić, D. Z., Marzo, T., Messori, L.,& Vasić, V. M. (2017). The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach.
Journal of Biological Inorganic Chemistry, 22(6), 819-832.
https://doi.org/10.1007/s00775-017-1460-5
Bondžić A, Čolović MB, Janjić GV, Zarić B, Petrović S, Krstić DZ, Marzo T, Messori L, Vasić VM. The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach. Journal of Biological Inorganic Chemistry. 2017;22(6):819-832
Bondžić Aleksandra, Čolović Mirjana B., Janjić Goran V., Zarić Božidarka, Petrović Sandra, Krstić Danijela Z., Marzo Tiziano, Messori Luigi, Vasić Vesna M., "The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach" Journal of Biological Inorganic Chemistry, 22, no. 6 (2017):819-832,
https://doi.org/10.1007/s00775-017-1460-5 .
3
3
3

Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity

Čolović, Mirjana B.; Medic, Branislava; Cetkovic, Mila; Kravić-Stevović, Tamara K.; Stojanovic, Marko; Ayass, Wassim W.; Mougharbel, Ali S.; Radenković, Miroslav; Prostran, Milica; Kortz, Ulrich; Krstić, Danijela Z.

(2017)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Medic, Branislava
AU  - Cetkovic, Mila
AU  - Kravić-Stevović, Tamara K.
AU  - Stojanovic, Marko
AU  - Ayass, Wassim W.
AU  - Mougharbel, Ali S.
AU  - Radenković, Miroslav
AU  - Prostran, Milica
AU  - Kortz, Ulrich
AU  - Krstić, Danijela Z.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1748
AB  - A toxicity evaluation of two Keggin-type heteropolytungstates, K-7[Ti2PW10O40].6H(2)O and K6H [SiV3W9O40].3H(2)O, with different inhibitory potencies toward acetylcholinesterase activity (IC50 values of 1.04 x 10(-6) and 4.80 x 10(-4) mol/L, respectively) was performed. Wistar albino rats were orally treated with single doses (5 and 50 mg/kg) of both investigated compounds. The biochemical parameters of renal (serum urea and creatinine) and liver function (direct and total bilirubin, alanine transaminase, and aspartate aminotransferase) were determined after 24 h and 14 days. A histopathological analysis of liver tissue was carried out 14 days after the polyoxotungstate administration. Both applied doses of the investigated compounds did not induce statistically significant alterations of the renal function markers. However, the polyoxotungstate treatment caused an increase in the activities of serum alanine transaminase and aspartate aminotransferase in a time- and concentration -dependent manner, although statistically significant changes in bilirubin concentrations were not observed. Furthermore, the detected hepatotoxic effect was confirmed by histhopathological analysis that suggested some reversible liver tissue damage two weeks after the treatment, especially in the case of K6H [SiV3W9O40]-3H(2)O. Accordingly, the toxicity of these two polyoxotungstates with anti-acetylcholinesterase effect cannot be considered as a severe one, but their potential clinical application would require a more complex toxicological study.
T2  - Toxicology and Applied Pharmacology
T1  - Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity
VL  - 333
SP  - 68
EP  - 75
DO  - 10.1016/j.taap.2017.08.010
ER  - 
@article{
author = "Čolović, Mirjana B. and Medic, Branislava and Cetkovic, Mila and Kravić-Stevović, Tamara K. and Stojanovic, Marko and Ayass, Wassim W. and Mougharbel, Ali S. and Radenković, Miroslav and Prostran, Milica and Kortz, Ulrich and Krstić, Danijela Z.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1748",
abstract = "A toxicity evaluation of two Keggin-type heteropolytungstates, K-7[Ti2PW10O40].6H(2)O and K6H [SiV3W9O40].3H(2)O, with different inhibitory potencies toward acetylcholinesterase activity (IC50 values of 1.04 x 10(-6) and 4.80 x 10(-4) mol/L, respectively) was performed. Wistar albino rats were orally treated with single doses (5 and 50 mg/kg) of both investigated compounds. The biochemical parameters of renal (serum urea and creatinine) and liver function (direct and total bilirubin, alanine transaminase, and aspartate aminotransferase) were determined after 24 h and 14 days. A histopathological analysis of liver tissue was carried out 14 days after the polyoxotungstate administration. Both applied doses of the investigated compounds did not induce statistically significant alterations of the renal function markers. However, the polyoxotungstate treatment caused an increase in the activities of serum alanine transaminase and aspartate aminotransferase in a time- and concentration -dependent manner, although statistically significant changes in bilirubin concentrations were not observed. Furthermore, the detected hepatotoxic effect was confirmed by histhopathological analysis that suggested some reversible liver tissue damage two weeks after the treatment, especially in the case of K6H [SiV3W9O40]-3H(2)O. Accordingly, the toxicity of these two polyoxotungstates with anti-acetylcholinesterase effect cannot be considered as a severe one, but their potential clinical application would require a more complex toxicological study.",
journal = "Toxicology and Applied Pharmacology",
title = "Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity",
volume = "333",
pages = "68-75",
doi = "10.1016/j.taap.2017.08.010"
}
Čolović, M. B., Medic, B., Cetkovic, M., Kravić-Stevović, T. K., Stojanovic, M., Ayass, W. W., Mougharbel, A. S., Radenković, M., Prostran, M., Kortz, U.,& Krstić, D. Z. (2017). Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity.
Toxicology and Applied Pharmacology, 333, 68-75.
https://doi.org/10.1016/j.taap.2017.08.010
Čolović MB, Medic B, Cetkovic M, Kravić-Stevović TK, Stojanovic M, Ayass WW, Mougharbel AS, Radenković M, Prostran M, Kortz U, Krstić DZ. Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity. Toxicology and Applied Pharmacology. 2017;333:68-75
Čolović Mirjana B., Medic Branislava, Cetkovic Mila, Kravić-Stevović Tamara K., Stojanovic Marko, Ayass Wassim W., Mougharbel Ali S., Radenković Miroslav, Prostran Milica, Kortz Ulrich, Krstić Danijela Z., "Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity" Toxicology and Applied Pharmacology, 333 (2017):68-75,
https://doi.org/10.1016/j.taap.2017.08.010 .
7
8
4
9

The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma

Jakovljević-Uzelac, Jovana; Čolović, Mirjana B.; Krstić, Danijela Z.; Đurić, Marko; Đurić, Dragan M.

(2017)

TY  - CONF
AU  - Jakovljević-Uzelac, Jovana
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Đurić, Marko
AU  - Đurić, Dragan M.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7175
C3  - Atherosclerosis
T1  - The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma
VL  - 263
SP  - E137
EP  - E138
DO  - 10.1016/j.atherosclerosis.2017.06.440
ER  - 
@conference{
author = "Jakovljević-Uzelac, Jovana and Čolović, Mirjana B. and Krstić, Danijela Z. and Đurić, Marko and Đurić, Dragan M.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7175",
journal = "Atherosclerosis",
title = "The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma",
volume = "263",
pages = "E137-E138",
doi = "10.1016/j.atherosclerosis.2017.06.440"
}
Jakovljević-Uzelac, J., Čolović, M. B., Krstić, D. Z., Đurić, M.,& Đurić, D. M. (2017). The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma.
Atherosclerosis, 263, E137-E138.
https://doi.org/10.1016/j.atherosclerosis.2017.06.440
Jakovljević-Uzelac J, Čolović MB, Krstić DZ, Đurić M, Đurić DM. The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma. Atherosclerosis. 2017;263:E137-E138
Jakovljević-Uzelac Jovana, Čolović Mirjana B., Krstić Danijela Z., Đurić Marko, Đurić Dragan M., "The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma" Atherosclerosis, 263 (2017):E137-E138,
https://doi.org/10.1016/j.atherosclerosis.2017.06.440 .

Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain

Hrncic, Dragan; Rasic-Markovic, Aleksandra; Čolović, Mirjana B.; Krstić, Danijela Z.; Sutulovic, Nikola; Grubac, Zeljko; Susic, Veselinka; Đurić, Dragan M.; Stanojlovic, Olivera

(2017)

TY  - CONF
AU  - Hrncic, Dragan
AU  - Rasic-Markovic, Aleksandra
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Sutulovic, Nikola
AU  - Grubac, Zeljko
AU  - Susic, Veselinka
AU  - Đurić, Dragan M.
AU  - Stanojlovic, Olivera
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7176
C3  - Atherosclerosis
T1  - Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain
VL  - 263
SP  - E168
EP  - E168
DO  - 10.1016/j.atherosclerosis.2017.06.536
ER  - 
@conference{
author = "Hrncic, Dragan and Rasic-Markovic, Aleksandra and Čolović, Mirjana B. and Krstić, Danijela Z. and Sutulovic, Nikola and Grubac, Zeljko and Susic, Veselinka and Đurić, Dragan M. and Stanojlovic, Olivera",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7176",
journal = "Atherosclerosis",
title = "Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain",
volume = "263",
pages = "E168-E168",
doi = "10.1016/j.atherosclerosis.2017.06.536"
}
Hrncic, D., Rasic-Markovic, A., Čolović, M. B., Krstić, D. Z., Sutulovic, N., Grubac, Z., Susic, V., Đurić, D. M.,& Stanojlovic, O. (2017). Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain.
Atherosclerosis, 263, E168-E168.
https://doi.org/10.1016/j.atherosclerosis.2017.06.536
Hrncic D, Rasic-Markovic A, Čolović MB, Krstić DZ, Sutulovic N, Grubac Z, Susic V, Đurić DM, Stanojlovic O. Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain. Atherosclerosis. 2017;263:E168-E168
Hrncic Dragan, Rasic-Markovic Aleksandra, Čolović Mirjana B., Krstić Danijela Z., Sutulovic Nikola, Grubac Zeljko, Susic Veselinka, Đurić Dragan M., Stanojlovic Olivera, "Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain" Atherosclerosis, 263 (2017):E168-E168,
https://doi.org/10.1016/j.atherosclerosis.2017.06.536 .

Advanced-level analysis of spiking EEG activity potentiated by high dietary methionine: contribution of purinergic signaling

Hrncic, D.; Markovic, A. Rasic; Sutulovici, N.; Grubac, Z.; Vorkapici, M.; Ademovici, A.; Čolović, Mirjana B.; Krstić, Danijela Z.; Petrovicl, B. Rankov; Susic, V.; Đurić, Dragan M.; Stanojlovic, O.

(2017)

TY  - CONF
AU  - Hrncic, D.
AU  - Markovic, A. Rasic
AU  - Sutulovici, N.
AU  - Grubac, Z.
AU  - Vorkapici, M.
AU  - Ademovici, A.
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Petrovicl, B. Rankov
AU  - Susic, V.
AU  - Đurić, Dragan M.
AU  - Stanojlovic, O.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1712
C3  - Acta Physiologica
T1  - Advanced-level analysis of spiking EEG activity potentiated by high dietary methionine: contribution of purinergic signaling
VL  - 221
IS  - SI
SP  - 4
EP  - 4
ER  - 
@conference{
author = "Hrncic, D. and Markovic, A. Rasic and Sutulovici, N. and Grubac, Z. and Vorkapici, M. and Ademovici, A. and Čolović, Mirjana B. and Krstić, Danijela Z. and Petrovicl, B. Rankov and Susic, V. and Đurić, Dragan M. and Stanojlovic, O.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1712",
journal = "Acta Physiologica",
title = "Advanced-level analysis of spiking EEG activity potentiated by high dietary methionine: contribution of purinergic signaling",
volume = "221",
number = "SI",
pages = "4-4"
}
Hrncic, D., Markovic, A. R., Sutulovici, N., Grubac, Z., Vorkapici, M., Ademovici, A., Čolović, M. B., Krstić, D. Z., Petrovicl, B. R., Susic, V., Đurić, D. M.,& Stanojlovic, O. (2017). Advanced-level analysis of spiking EEG activity potentiated by high dietary methionine: contribution of purinergic signaling.
Acta Physiologica, 221(SI), 4-4.
Hrncic D, Markovic AR, Sutulovici N, Grubac Z, Vorkapici M, Ademovici A, Čolović MB, Krstić DZ, Petrovicl BR, Susic V, Đurić DM, Stanojlovic O. Advanced-level analysis of spiking EEG activity potentiated by high dietary methionine: contribution of purinergic signaling. Acta Physiologica. 2017;221(SI):4-4
Hrncic D., Markovic A. Rasic, Sutulovici N., Grubac Z., Vorkapici M., Ademovici A., Čolović Mirjana B., Krstić Danijela Z., Petrovicl B. Rankov, Susic V., Đurić Dragan M., Stanojlovic O., "Advanced-level analysis of spiking EEG activity potentiated by high dietary methionine: contribution of purinergic signaling" Acta Physiologica, 221, no. SI (2017):4-4

The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures

Rasic-Markovic, A.; Hrncic, D.; Krstić, Danijela Z.; Čolović, Mirjana B.; Djuric, E.; Rankov-Petrovic, B.; Susic, V.; Stanojlovic, O.; Đurić, Dragan M.

(2016)

TY  - JOUR
AU  - Rasic-Markovic, A.
AU  - Hrncic, D.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Djuric, E.
AU  - Rankov-Petrovic, B.
AU  - Susic, V.
AU  - Stanojlovic, O.
AU  - Đurić, Dragan M.
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7114
AB  - The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.
T2  - Canadian Journal of Physiology and Pharmacology
T1  - The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures
VL  - 94
IS  - 10
SP  - 1083
EP  - 1089
DO  - 10.1139/cjpp-2016-0076
ER  - 
@article{
author = "Rasic-Markovic, A. and Hrncic, D. and Krstić, Danijela Z. and Čolović, Mirjana B. and Djuric, E. and Rankov-Petrovic, B. and Susic, V. and Stanojlovic, O. and Đurić, Dragan M.",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7114",
abstract = "The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.",
journal = "Canadian Journal of Physiology and Pharmacology",
title = "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures",
volume = "94",
number = "10",
pages = "1083-1089",
doi = "10.1139/cjpp-2016-0076"
}
Rasic-Markovic, A., Hrncic, D., Krstić, D. Z., Čolović, M. B., Djuric, E., Rankov-Petrovic, B., Susic, V., Stanojlovic, O.,& Đurić, D. M. (2016). The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures.
Canadian Journal of Physiology and Pharmacology, 94(10), 1083-1089.
https://doi.org/10.1139/cjpp-2016-0076
Rasic-Markovic A, Hrncic D, Krstić DZ, Čolović MB, Djuric E, Rankov-Petrovic B, Susic V, Stanojlovic O, Đurić DM. The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures. Canadian Journal of Physiology and Pharmacology. 2016;94(10):1083-1089
Rasic-Markovic A., Hrncic D., Krstić Danijela Z., Čolović Mirjana B., Djuric E., Rankov-Petrovic B., Susic V., Stanojlovic O., Đurić Dragan M., "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures" Canadian Journal of Physiology and Pharmacology, 94, no. 10 (2016):1083-1089,
https://doi.org/10.1139/cjpp-2016-0076 .
8
8
10

A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na+/K+-ATPase

Xu, Xiao; Bosnjakovic-Pavlovic, Nada; Čolović, Mirjana B.; Krstić, Danijela Z.; Vasić, Vesna M.; Gillet, Jean-Michel; Wu, Pingfan; Wei, Yongge; Spasojević-de Bire, Anne

(2016)

TY  - JOUR
AU  - Xu, Xiao
AU  - Bosnjakovic-Pavlovic, Nada
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Vasić, Vesna M.
AU  - Gillet, Jean-Michel
AU  - Wu, Pingfan
AU  - Wei, Yongge
AU  - Spasojević-de Bire, Anne
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1158
AB  - In vitro influence of five synthesized functionalized hexavanadates (V-6) on commercial porcine cerebral cortex Na+/K+-ATPase activity has been studied. Dose dependent Na+/K+-ATPase inhibition was obtained for all investigated compounds. Calculated half maximal inhibitory concentration IC50 values, in mol/L, for Na+/K+-ATPase were 7.6 x 10(-5), 1.8 x 10(-5), 2.9 x 10(-5), 5.5 x 10(-5) for functionalized hexavanadates (V-6) with tetrabutylammonium (TBA) [V-6-CH3][TBA](2), [V-6-NO2][TBA](2), [V-6-OH][TBA](2) and [V-6-C-3][TBA](2) respectively. [V-6-OH][Na](2) inhibited Na+/K+-ATPase activity up to 30% at maximal investigated concentration 1 x 10(-3) mol/L. This reactivity has been interpreted using a study of the non-covalent interactions of functionalized hexavanadate hybrids through Cambridge Structural Database (CSD) analysis. Bibliographic searching has led to 18 different structures and 99 contacts. We have observed that C-H center dot center dot center dot O contacts consolidate the structures. We have also performed density functional theory (DFT) calculations and have determined electrostatic potential values at the molecular surface on a series of functionalized V-6. These results enlightened their chemical reactivity and their potential biological applications such as the inhibition of the ATPase. (C) 2016 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na+/K+-ATPase
VL  - 161
SP  - 27
EP  - 36
DO  - 10.1016/j.jinorgbio.2016.04.029
ER  - 
@article{
author = "Xu, Xiao and Bosnjakovic-Pavlovic, Nada and Čolović, Mirjana B. and Krstić, Danijela Z. and Vasić, Vesna M. and Gillet, Jean-Michel and Wu, Pingfan and Wei, Yongge and Spasojević-de Bire, Anne",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1158",
abstract = "In vitro influence of five synthesized functionalized hexavanadates (V-6) on commercial porcine cerebral cortex Na+/K+-ATPase activity has been studied. Dose dependent Na+/K+-ATPase inhibition was obtained for all investigated compounds. Calculated half maximal inhibitory concentration IC50 values, in mol/L, for Na+/K+-ATPase were 7.6 x 10(-5), 1.8 x 10(-5), 2.9 x 10(-5), 5.5 x 10(-5) for functionalized hexavanadates (V-6) with tetrabutylammonium (TBA) [V-6-CH3][TBA](2), [V-6-NO2][TBA](2), [V-6-OH][TBA](2) and [V-6-C-3][TBA](2) respectively. [V-6-OH][Na](2) inhibited Na+/K+-ATPase activity up to 30% at maximal investigated concentration 1 x 10(-3) mol/L. This reactivity has been interpreted using a study of the non-covalent interactions of functionalized hexavanadate hybrids through Cambridge Structural Database (CSD) analysis. Bibliographic searching has led to 18 different structures and 99 contacts. We have observed that C-H center dot center dot center dot O contacts consolidate the structures. We have also performed density functional theory (DFT) calculations and have determined electrostatic potential values at the molecular surface on a series of functionalized V-6. These results enlightened their chemical reactivity and their potential biological applications such as the inhibition of the ATPase. (C) 2016 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na+/K+-ATPase",
volume = "161",
pages = "27-36",
doi = "10.1016/j.jinorgbio.2016.04.029"
}
Xu, X., Bosnjakovic-Pavlovic, N., Čolović, M. B., Krstić, D. Z., Vasić, V. M., Gillet, J., Wu, P., Wei, Y.,& Spasojević-de Bire, A. (2016). A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na+/K+-ATPase.
Journal of Inorganic Biochemistry, 161, 27-36.
https://doi.org/10.1016/j.jinorgbio.2016.04.029
Xu X, Bosnjakovic-Pavlovic N, Čolović MB, Krstić DZ, Vasić VM, Gillet J, Wu P, Wei Y, Spasojević-de Bire A. A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na+/K+-ATPase. Journal of Inorganic Biochemistry. 2016;161:27-36
Xu Xiao, Bosnjakovic-Pavlovic Nada, Čolović Mirjana B., Krstić Danijela Z., Vasić Vesna M., Gillet Jean-Michel, Wu Pingfan, Wei Yongge, Spasojević-de Bire Anne, "A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na+/K+-ATPase" Journal of Inorganic Biochemistry, 161 (2016):27-36,
https://doi.org/10.1016/j.jinorgbio.2016.04.029 .
15
15
16

Biochemical Markers of Renal Function

Krstić, Danijela Z.; Tomic, Nenad; Radosavljevic, Branimir; Avramović, Nataša; Dragutinovic, Vesna; Skodric, Sanja Radojevic; Čolović, Mirjana B.

(2016)

TY  - JOUR
AU  - Krstić, Danijela Z.
AU  - Tomic, Nenad
AU  - Radosavljevic, Branimir
AU  - Avramović, Nataša
AU  - Dragutinovic, Vesna
AU  - Skodric, Sanja Radojevic
AU  - Čolović, Mirjana B.
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1200
AB  - Kidney damage can be induced by ischemia, autoimmune diseases, hypertension, allograft rejection, metabolic or genetic disorders, infections or toxins. The influence of these factors could result in acute kidney injury (AKI) defined as an unexpected decrease in urine output or renal function, or encourage the development of chronic kidney disease (CKD). Biomarkers of renal function, measured in urine and serum, are in increasing use in order to estimate the severity and nature of kidney injury, and consequently apply appropriate therapy and improve patient management. The determined values of biomarkers can suggest the potential risk of kidney disease and the type of renal injury, predict the disease progression, as well as be helpful for assessing the response to an applied therapy. Although novel biomarkers are in practical use, serum creatinine, the indicator of glomerular filtration rate is still the most frequently used biomarker of renal function despite its known limitations. In recent decades, numerous studies resulted in discovering urinary and serum proteins that can serve as biomarkers for early and accurate detection of AKI and its development, as well as the identification of CKD. This review gives an overview of the most important renal biomarkers investigated in kidney diseases, classified in following types: functional biomarkers, up-regulated proteins, enzymes, and cycle arrest biomarkers. It describes their properties, physiological roles, and discusses the utility of these molecules in different clinical settings.
T2  - Current Medicinal Chemistry
T1  - Biochemical Markers of Renal Function
VL  - 23
IS  - 19
SP  - 2018
EP  - 2040
DO  - 10.2174/0929867323666160115130241
ER  - 
@article{
author = "Krstić, Danijela Z. and Tomic, Nenad and Radosavljevic, Branimir and Avramović, Nataša and Dragutinovic, Vesna and Skodric, Sanja Radojevic and Čolović, Mirjana B.",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1200",
abstract = "Kidney damage can be induced by ischemia, autoimmune diseases, hypertension, allograft rejection, metabolic or genetic disorders, infections or toxins. The influence of these factors could result in acute kidney injury (AKI) defined as an unexpected decrease in urine output or renal function, or encourage the development of chronic kidney disease (CKD). Biomarkers of renal function, measured in urine and serum, are in increasing use in order to estimate the severity and nature of kidney injury, and consequently apply appropriate therapy and improve patient management. The determined values of biomarkers can suggest the potential risk of kidney disease and the type of renal injury, predict the disease progression, as well as be helpful for assessing the response to an applied therapy. Although novel biomarkers are in practical use, serum creatinine, the indicator of glomerular filtration rate is still the most frequently used biomarker of renal function despite its known limitations. In recent decades, numerous studies resulted in discovering urinary and serum proteins that can serve as biomarkers for early and accurate detection of AKI and its development, as well as the identification of CKD. This review gives an overview of the most important renal biomarkers investigated in kidney diseases, classified in following types: functional biomarkers, up-regulated proteins, enzymes, and cycle arrest biomarkers. It describes their properties, physiological roles, and discusses the utility of these molecules in different clinical settings.",
journal = "Current Medicinal Chemistry",
title = "Biochemical Markers of Renal Function",
volume = "23",
number = "19",
pages = "2018-2040",
doi = "10.2174/0929867323666160115130241"
}
Krstić, D. Z., Tomic, N., Radosavljevic, B., Avramović, N., Dragutinovic, V., Skodric, S. R.,& Čolović, M. B. (2016). Biochemical Markers of Renal Function.
Current Medicinal Chemistry, 23(19), 2018-2040.
https://doi.org/10.2174/0929867323666160115130241
Krstić DZ, Tomic N, Radosavljevic B, Avramović N, Dragutinovic V, Skodric SR, Čolović MB. Biochemical Markers of Renal Function. Current Medicinal Chemistry. 2016;23(19):2018-2040
Krstić Danijela Z., Tomic Nenad, Radosavljevic Branimir, Avramović Nataša, Dragutinovic Vesna, Skodric Sanja Radojevic, Čolović Mirjana B., "Biochemical Markers of Renal Function" Current Medicinal Chemistry, 23, no. 19 (2016):2018-2040,
https://doi.org/10.2174/0929867323666160115130241 .
14
13
12

In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes

Čolović, Mirjana B.; Vasić, Vesna M.; Avramović, Nataša; Gajic, Milan M.; Đurić, Dragan M.; Krstić, Danijela Z.

(2015)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Vasić, Vesna M.
AU  - Avramović, Nataša
AU  - Gajic, Milan M.
AU  - Đurić, Dragan M.
AU  - Krstić, Danijela Z.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/409
AB  - Although primary toxic action of organophosphorous insecticides is associated with acetylcholinesterase inhibition, later studies suggest that oxidative stress may be responsible for induced organophosphates toxicity. These studies mostly include thio forms, while the effects of their metabolites/ degradation products have been less investigated. Therefore, this paper studies the toxic effects of diazinon degradation products, diazoxon and 2-isopropyl-6-methyl-4-pyrimidinol, and compares them with the toxic potential of the parent compound. The toxicity induced by various concentrations of the investigated compounds was in vitro evaluated by the activities of acetylcholinesterase, ATPases, antioxidant defense enzymes and lactate dehydrogenase, and malondialdehyde level in rat brain synaptosomes. Diazinon inhibited acetylcholinesterase and Na+/K+-ATPase in dose-dependent manner, while the inhibition of ecto-ATPase activity was less than 15% at all investigated concentrations. It did not demonstrate noteworthy prooxidative properties causing increase (up to 10%) in antioxidant enzymes activity and malondialdehyde level, as a marker of lipid peroxidation. Diazinon oxidation product, diazoxon was found as the most toxic investigated compound. Beside the expected strong inhibitory effect on acetylcholinesterase, it induced dose-dependent and almost complete inhibition of Na+/K+-ATPase and ecto-ATPase at the highest investigated concentration (0.1 mM). Increasing diazoxon concentrations activated catalase (up to 30%), superoxide dismutase (up to 50%), glutathione peroxidase (up to 30%), and significantly increased malondialdehyde level (up to 50%). The investigated hydrolysis product of diazinon, 2-isopropyl-6-methyl-4-pyrimidinol did not remarkably alter the activities of acetylcholinesterase, Na+/K+-ATPase, catalase, glutathione peroxidase and lipid peroxidation level (up to about 10%). Although this diazinon metabolite has been known as non toxic, it induced superoxide dismutase stimulation up to 30%. Finally, even high concentrations of both diazinon and its metabolites did noticeably affect lactate dehydrogenase activity as a marker of synaptosomal integrity. The changes in investigated biochemical parameters in rat brain synaptosomes could serve as indicators of toxicity due to the exposure to thio organophosphates and/or their break-down products. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
T2  - Toxicology Letters
T1  - In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes
VL  - 233
IS  - 1
SP  - 29
EP  - 37
DO  - 10.1016/j.toxlet.2015.01.003
ER  - 
@article{
author = "Čolović, Mirjana B. and Vasić, Vesna M. and Avramović, Nataša and Gajic, Milan M. and Đurić, Dragan M. and Krstić, Danijela Z.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/409",
abstract = "Although primary toxic action of organophosphorous insecticides is associated with acetylcholinesterase inhibition, later studies suggest that oxidative stress may be responsible for induced organophosphates toxicity. These studies mostly include thio forms, while the effects of their metabolites/ degradation products have been less investigated. Therefore, this paper studies the toxic effects of diazinon degradation products, diazoxon and 2-isopropyl-6-methyl-4-pyrimidinol, and compares them with the toxic potential of the parent compound. The toxicity induced by various concentrations of the investigated compounds was in vitro evaluated by the activities of acetylcholinesterase, ATPases, antioxidant defense enzymes and lactate dehydrogenase, and malondialdehyde level in rat brain synaptosomes. Diazinon inhibited acetylcholinesterase and Na+/K+-ATPase in dose-dependent manner, while the inhibition of ecto-ATPase activity was less than 15% at all investigated concentrations. It did not demonstrate noteworthy prooxidative properties causing increase (up to 10%) in antioxidant enzymes activity and malondialdehyde level, as a marker of lipid peroxidation. Diazinon oxidation product, diazoxon was found as the most toxic investigated compound. Beside the expected strong inhibitory effect on acetylcholinesterase, it induced dose-dependent and almost complete inhibition of Na+/K+-ATPase and ecto-ATPase at the highest investigated concentration (0.1 mM). Increasing diazoxon concentrations activated catalase (up to 30%), superoxide dismutase (up to 50%), glutathione peroxidase (up to 30%), and significantly increased malondialdehyde level (up to 50%). The investigated hydrolysis product of diazinon, 2-isopropyl-6-methyl-4-pyrimidinol did not remarkably alter the activities of acetylcholinesterase, Na+/K+-ATPase, catalase, glutathione peroxidase and lipid peroxidation level (up to about 10%). Although this diazinon metabolite has been known as non toxic, it induced superoxide dismutase stimulation up to 30%. Finally, even high concentrations of both diazinon and its metabolites did noticeably affect lactate dehydrogenase activity as a marker of synaptosomal integrity. The changes in investigated biochemical parameters in rat brain synaptosomes could serve as indicators of toxicity due to the exposure to thio organophosphates and/or their break-down products. (C) 2015 Elsevier Ireland Ltd. All rights reserved.",
journal = "Toxicology Letters",
title = "In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes",
volume = "233",
number = "1",
pages = "29-37",
doi = "10.1016/j.toxlet.2015.01.003"
}
Čolović, M. B., Vasić, V. M., Avramović, N., Gajic, M. M., Đurić, D. M.,& Krstić, D. Z. (2015). In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes.
Toxicology Letters, 233(1), 29-37.
https://doi.org/10.1016/j.toxlet.2015.01.003
Čolović MB, Vasić VM, Avramović N, Gajic MM, Đurić DM, Krstić DZ. In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes. Toxicology Letters. 2015;233(1):29-37
Čolović Mirjana B., Vasić Vesna M., Avramović Nataša, Gajic Milan M., Đurić Dragan M., Krstić Danijela Z., "In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes" Toxicology Letters, 233, no. 1 (2015):29-37,
https://doi.org/10.1016/j.toxlet.2015.01.003 .
26
23
31

The effect of subchronic supplementation with folic acid on homocysteine induced seizures

Rasic-Markovic, A.; Rankov-Petrovic, B.; Hrncic, D.; Krstić, Danijela Z.; Čolović, Mirjana B.; Macut, Dj; Đurić, Dragan M.; Stanojlovic, O.

(2015)

TY  - JOUR
AU  - Rasic-Markovic, A.
AU  - Rankov-Petrovic, B.
AU  - Hrncic, D.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Macut, Dj
AU  - Đurić, Dragan M.
AU  - Stanojlovic, O.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/619
AB  - Influence of folic acid on the CNS is still unclear. Folate has a neuroprotective effect, while on the other hand excess folate can exacerbate seizures in epileptics. The aim of the present study was to examine the effect of subchronic administration of folic acid on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone induced seizures in adult rats. The activity of Na+/K+-ATPase and Mg2+-ATPase in different brain regions was investigated. Adult male Wistar rats were divided into groups: 1. Controls (C, 0.9% NaCl); 2. DL homocysteine-thiolactone 8.0 mmol/kg (H); 3. Subchronic supplementation with folic acid 5 mg/kg for 7 days (F) and 4. Subchronic supplementation with F + single dose of H (FH). Seizure behaviour was assessed by incidence, latency, number and intensity of seizure episodes. Seizure severity was described by a descriptive scale with grades 0-4. For EEG recordings, three gold-plated recording electrodes were implanted into the skull. Subchronic supplementation with folic acid did not affect seizure incidence, median number of seizure episodes and severity in FH, comparison with H (p GT 0.05). The majority of seizure episodes in all groups were of grade 2. There were no significant differences in lethal outcomes at 24 h upon H injection in the FH vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in the FH vs. H group. Subchronic folic acid administration did not exacerbate H induced seizures and completely recovered the activity of ATPases.
T2  - Acta Physiologica Hungarica
T1  - The effect of subchronic supplementation with folic acid on homocysteine induced seizures
VL  - 102
IS  - 2
SP  - 151
EP  - 162
DO  - 10.1556/036.102.2015.2.6
ER  - 
@article{
author = "Rasic-Markovic, A. and Rankov-Petrovic, B. and Hrncic, D. and Krstić, Danijela Z. and Čolović, Mirjana B. and Macut, Dj and Đurić, Dragan M. and Stanojlovic, O.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/619",
abstract = "Influence of folic acid on the CNS is still unclear. Folate has a neuroprotective effect, while on the other hand excess folate can exacerbate seizures in epileptics. The aim of the present study was to examine the effect of subchronic administration of folic acid on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone induced seizures in adult rats. The activity of Na+/K+-ATPase and Mg2+-ATPase in different brain regions was investigated. Adult male Wistar rats were divided into groups: 1. Controls (C, 0.9% NaCl); 2. DL homocysteine-thiolactone 8.0 mmol/kg (H); 3. Subchronic supplementation with folic acid 5 mg/kg for 7 days (F) and 4. Subchronic supplementation with F + single dose of H (FH). Seizure behaviour was assessed by incidence, latency, number and intensity of seizure episodes. Seizure severity was described by a descriptive scale with grades 0-4. For EEG recordings, three gold-plated recording electrodes were implanted into the skull. Subchronic supplementation with folic acid did not affect seizure incidence, median number of seizure episodes and severity in FH, comparison with H (p GT 0.05). The majority of seizure episodes in all groups were of grade 2. There were no significant differences in lethal outcomes at 24 h upon H injection in the FH vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in the FH vs. H group. Subchronic folic acid administration did not exacerbate H induced seizures and completely recovered the activity of ATPases.",
journal = "Acta Physiologica Hungarica",
title = "The effect of subchronic supplementation with folic acid on homocysteine induced seizures",
volume = "102",
number = "2",
pages = "151-162",
doi = "10.1556/036.102.2015.2.6"
}
Rasic-Markovic, A., Rankov-Petrovic, B., Hrncic, D., Krstić, D. Z., Čolović, M. B., Macut, D., Đurić, D. M.,& Stanojlovic, O. (2015). The effect of subchronic supplementation with folic acid on homocysteine induced seizures.
Acta Physiologica Hungarica, 102(2), 151-162.
https://doi.org/10.1556/036.102.2015.2.6
Rasic-Markovic A, Rankov-Petrovic B, Hrncic D, Krstić DZ, Čolović MB, Macut D, Đurić DM, Stanojlovic O. The effect of subchronic supplementation with folic acid on homocysteine induced seizures. Acta Physiologica Hungarica. 2015;102(2):151-162
Rasic-Markovic A., Rankov-Petrovic B., Hrncic D., Krstić Danijela Z., Čolović Mirjana B., Macut Dj, Đurić Dragan M., Stanojlovic O., "The effect of subchronic supplementation with folic acid on homocysteine induced seizures" Acta Physiologica Hungarica, 102, no. 2 (2015):151-162,
https://doi.org/10.1556/036.102.2015.2.6 .
4
4
4

Effects of methionine-enriched diet on the rat heart and aorta

Đurić, Dragan M.; Stanojlovic, O.; Hrncic, D.; Puškaš, Nela; Rasic-Markovic, A.; Čolović, Mirjana B.; Krstić, Danijela Z.; Bjekic, J. M.; Grubac, Z.; Sutulovic, N.; Susic, V.

(2014)

TY  - CONF
AU  - Đurić, Dragan M.
AU  - Stanojlovic, O.
AU  - Hrncic, D.
AU  - Puškaš, Nela
AU  - Rasic-Markovic, A.
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Bjekic, J. M.
AU  - Grubac, Z.
AU  - Sutulovic, N.
AU  - Susic, V.
PY  - 2014
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/72
C3  - Acta Physiologica
T1  - Effects of methionine-enriched diet on the rat heart and aorta
VL  - 211
IS  - SI
SP  - 78
EP  - 78
ER  - 
@conference{
author = "Đurić, Dragan M. and Stanojlovic, O. and Hrncic, D. and Puškaš, Nela and Rasic-Markovic, A. and Čolović, Mirjana B. and Krstić, Danijela Z. and Bjekic, J. M. and Grubac, Z. and Sutulovic, N. and Susic, V.",
year = "2014",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/72",
journal = "Acta Physiologica",
title = "Effects of methionine-enriched diet on the rat heart and aorta",
volume = "211",
number = "SI",
pages = "78-78"
}
Đurić, D. M., Stanojlovic, O., Hrncic, D., Puškaš, N., Rasic-Markovic, A., Čolović, M. B., Krstić, D. Z., Bjekic, J. M., Grubac, Z., Sutulovic, N.,& Susic, V. (2014). Effects of methionine-enriched diet on the rat heart and aorta.
Acta Physiologica, 211(SI), 78-78.
Đurić DM, Stanojlovic O, Hrncic D, Puškaš N, Rasic-Markovic A, Čolović MB, Krstić DZ, Bjekic JM, Grubac Z, Sutulovic N, Susic V. Effects of methionine-enriched diet on the rat heart and aorta. Acta Physiologica. 2014;211(SI):78-78
Đurić Dragan M., Stanojlovic O., Hrncic D., Puškaš Nela, Rasic-Markovic A., Čolović Mirjana B., Krstić Danijela Z., Bjekic J. M., Grubac Z., Sutulovic N., Susic V., "Effects of methionine-enriched diet on the rat heart and aorta" Acta Physiologica, 211, no. SI (2014):78-78

Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress

Hrncic, D.; Rasic-Markovic, A.; Lekovic, J.; Krstić, Danijela Z.; Čolović, Mirjana B.; Macut, D.; Susic, V.; Đurić, Dragan M.; Stanojlovic, O.

(2014)

TY  - JOUR
AU  - Hrncic, D.
AU  - Rasic-Markovic, A.
AU  - Lekovic, J.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Macut, D.
AU  - Susic, V.
AU  - Đurić, Dragan M.
AU  - Stanojlovic, O.
PY  - 2014
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/6049
AB  - The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.
T2  - International Journal of Sports Medicine
T1  - Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress
VL  - 35
IS  - 7
SP  - 544
EP  - 550
DO  - 10.1055/s-0033-1357162
ER  - 
@article{
author = "Hrncic, D. and Rasic-Markovic, A. and Lekovic, J. and Krstić, Danijela Z. and Čolović, Mirjana B. and Macut, D. and Susic, V. and Đurić, Dragan M. and Stanojlovic, O.",
year = "2014",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/6049",
abstract = "The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.",
journal = "International Journal of Sports Medicine",
title = "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress",
volume = "35",
number = "7",
pages = "544-550",
doi = "10.1055/s-0033-1357162"
}
Hrncic, D., Rasic-Markovic, A., Lekovic, J., Krstić, D. Z., Čolović, M. B., Macut, D., Susic, V., Đurić, D. M.,& Stanojlovic, O. (2014). Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress.
International Journal of Sports Medicine, 35(7), 544-550.
https://doi.org/10.1055/s-0033-1357162
Hrncic D, Rasic-Markovic A, Lekovic J, Krstić DZ, Čolović MB, Macut D, Susic V, Đurić DM, Stanojlovic O. Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. International Journal of Sports Medicine. 2014;35(7):544-550
Hrncic D., Rasic-Markovic A., Lekovic J., Krstić Danijela Z., Čolović Mirjana B., Macut D., Susic V., Đurić Dragan M., Stanojlovic O., "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress" International Journal of Sports Medicine, 35, no. 7 (2014):544-550,
https://doi.org/10.1055/s-0033-1357162 .
10
11
12

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

Čolović, Mirjana B.; Krstić, Danijela Z.; Lazarević-Pašti, Tamara; Bondžić, Aleksandra; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Lazarević-Pašti, Tamara
AU  - Bondžić, Aleksandra
AU  - Vasić, Vesna M.
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5474
AB  - Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. In the case of reversible inhibitors being commonly applied in neurodegenerative disorders treatment, special attention is paid to currently approved drugs (donepezil, rivastigmine and galantamine) in the pharmacotherapy of Alzheimers disease, and toxic carbamates used as pesticides. Subsequently, mechanism of irreversible acetylcholinesterase inhibition induced by organophosphorus compounds (insecticides and nerve agents), and their specific and nonspecific toxic effects are described, as well as irreversible inhibitors having pharmacological implementation. In addition, the pharmacological treatment of intoxication caused by organophosphates is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning. Besides, organophosphorus and carbamate insecticides can be detoxified in mammals through enzymatic hydrolysis before they reach targets in the nervous system. Carboxylesterases most effectively decompose carbamates, whereas the most successful route of organophosphates detoxification is their degradation by corresponding phosphotriesterases.
T2  - Current Neuropharmacology
T1  - Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
VL  - 11
IS  - 3
SP  - 315
EP  - 335
DO  - 10.2174/1570159X11311030006
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Lazarević-Pašti, Tamara and Bondžić, Aleksandra and Vasić, Vesna M.",
year = "2013",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/5474",
abstract = "Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. In the case of reversible inhibitors being commonly applied in neurodegenerative disorders treatment, special attention is paid to currently approved drugs (donepezil, rivastigmine and galantamine) in the pharmacotherapy of Alzheimers disease, and toxic carbamates used as pesticides. Subsequently, mechanism of irreversible acetylcholinesterase inhibition induced by organophosphorus compounds (insecticides and nerve agents), and their specific and nonspecific toxic effects are described, as well as irreversible inhibitors having pharmacological implementation. In addition, the pharmacological treatment of intoxication caused by organophosphates is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning. Besides, organophosphorus and carbamate insecticides can be detoxified in mammals through enzymatic hydrolysis before they reach targets in the nervous system. Carboxylesterases most effectively decompose carbamates, whereas the most successful route of organophosphates detoxification is their degradation by corresponding phosphotriesterases.",
journal = "Current Neuropharmacology",
title = "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology",
volume = "11",
number = "3",
pages = "315-335",
doi = "10.2174/1570159X11311030006"
}
Čolović, M. B., Krstić, D. Z., Lazarević-Pašti, T., Bondžić, A.,& Vasić, V. M. (2013). Acetylcholinesterase Inhibitors: Pharmacology and Toxicology.
Current Neuropharmacology, 11(3), 315-335.
https://doi.org/10.2174/1570159X11311030006
Čolović MB, Krstić DZ, Lazarević-Pašti T, Bondžić A, Vasić VM. Acetylcholinesterase Inhibitors: Pharmacology and Toxicology. Current Neuropharmacology. 2013;11(3):315-335
Čolović Mirjana B., Krstić Danijela Z., Lazarević-Pašti Tamara, Bondžić Aleksandra, Vasić Vesna M., "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology" Current Neuropharmacology, 11, no. 3 (2013):315-335,
https://doi.org/10.2174/1570159X11311030006 .
76
973
862
978

Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes

Čolović, Mirjana B.; Krstić, Danijela Z.; Vasić, Vesna M.; Bondžić, Aleksandra; Uscumlic, Gordana S.; Petrovic, Slobodan D.

(2013)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Vasić, Vesna M.
AU  - Bondžić, Aleksandra
AU  - Uscumlic, Gordana S.
AU  - Petrovic, Slobodan D.
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5599
AB  - Organophosphorus insecticides have been the most applied group of insectcides for the last two decades. Their main toxic effects are related to irreversible inactivation of acetylcholinesterase (AChE). Actually, they covalently bind to serine OH group in the enzyme active site forming phosphorylated enzyme that cannot hydrolyze acetylcholine. Organophosphorus insecticides in the environment undergo the natural degradation pathway including mainly homogeneous and heterogeneous hydrolysis (especially at high pH) generating non-inhibiting products. Additionally, thio organophosphates are easily oxidized by naturally present oxidants and UV light, forming more toxic and stable oxons. Thus, oxidative degradation procedures, generally referred as advanced oxidation processes (AOP), have been applied for their efficient removal from contaminated waters. The most applied bioassays to monitor the organophosphate toxicity, i.e., the detoxification degree during AOP are Vibrio fischeri and AChE bioassays. Vibrio fischeri toxicity test exploits bioluminescence as the measure of luciferase activity of this marine bacterium, whereas AChE bioassay is based on AChE activity inhibition. Both bioanalytical techniques are rapid (several minutes), simple, sensitive and reproducible. Vibrio fischeri test seems to be a versatile indicator of toxic compounds generated in AOP for organophosphorus insecticides degradation. However, detection of neurotoxic AChE inhibitors, which can be formed in AOP of some organophosphates, requires AChE bioassays. Therefore, AChE toxicity test is more appropriate for monitoring the degradation processes of thio organophosphates, because more toxic oxo organophosphates might be formed and overlooked by Vibrio fischeri bioluminescence inhibition. In addition, during organophosphates removal by AOP, compounds with strong genotoxic potential may be formed, which cannot be detected by standard toxicity tests. For this reason, determination of incidence of micronuclei and cell proliferation index in cultivated human lymphocytes and fibroblasts is suitable for evaluation of organophosphorus insecticides and their break down products inducing cytogenetic damage.
T2  - Hemijska industrija
T1  - Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes
VL  - 67
IS  - 2
SP  - 217
EP  - 230
DO  - 10.2298/HEMIND120323060C
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Vasić, Vesna M. and Bondžić, Aleksandra and Uscumlic, Gordana S. and Petrovic, Slobodan D.",
year = "2013",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/5599",
abstract = "Organophosphorus insecticides have been the most applied group of insectcides for the last two decades. Their main toxic effects are related to irreversible inactivation of acetylcholinesterase (AChE). Actually, they covalently bind to serine OH group in the enzyme active site forming phosphorylated enzyme that cannot hydrolyze acetylcholine. Organophosphorus insecticides in the environment undergo the natural degradation pathway including mainly homogeneous and heterogeneous hydrolysis (especially at high pH) generating non-inhibiting products. Additionally, thio organophosphates are easily oxidized by naturally present oxidants and UV light, forming more toxic and stable oxons. Thus, oxidative degradation procedures, generally referred as advanced oxidation processes (AOP), have been applied for their efficient removal from contaminated waters. The most applied bioassays to monitor the organophosphate toxicity, i.e., the detoxification degree during AOP are Vibrio fischeri and AChE bioassays. Vibrio fischeri toxicity test exploits bioluminescence as the measure of luciferase activity of this marine bacterium, whereas AChE bioassay is based on AChE activity inhibition. Both bioanalytical techniques are rapid (several minutes), simple, sensitive and reproducible. Vibrio fischeri test seems to be a versatile indicator of toxic compounds generated in AOP for organophosphorus insecticides degradation. However, detection of neurotoxic AChE inhibitors, which can be formed in AOP of some organophosphates, requires AChE bioassays. Therefore, AChE toxicity test is more appropriate for monitoring the degradation processes of thio organophosphates, because more toxic oxo organophosphates might be formed and overlooked by Vibrio fischeri bioluminescence inhibition. In addition, during organophosphates removal by AOP, compounds with strong genotoxic potential may be formed, which cannot be detected by standard toxicity tests. For this reason, determination of incidence of micronuclei and cell proliferation index in cultivated human lymphocytes and fibroblasts is suitable for evaluation of organophosphorus insecticides and their break down products inducing cytogenetic damage.",
journal = "Hemijska industrija",
title = "Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes",
volume = "67",
number = "2",
pages = "217-230",
doi = "10.2298/HEMIND120323060C"
}
Čolović, M. B., Krstić, D. Z., Vasić, V. M., Bondžić, A., Uscumlic, G. S.,& Petrovic, S. D. (2013). Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes.
Hemijska industrija, 67(2), 217-230.
https://doi.org/10.2298/HEMIND120323060C
Čolović MB, Krstić DZ, Vasić VM, Bondžić A, Uscumlic GS, Petrovic SD. Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes. Hemijska industrija. 2013;67(2):217-230
Čolović Mirjana B., Krstić Danijela Z., Vasić Vesna M., Bondžić Aleksandra, Uscumlic Gordana S., Petrovic Slobodan D., "Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes" Hemijska industrija, 67, no. 2 (2013):217-230,
https://doi.org/10.2298/HEMIND120323060C .
5
3
6

In vitro effects of some gold complexes on Na+/K+ ATPase activity and cell proliferation

Petrovic, Voin; Čolović, Mirjana B.; Krstić, Danijela Z.; Vujačić, Ana V.; Petrović, Sandra; Joksić, Gordana; Bugarcic, Zivadin; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Petrovic, Voin
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Vujačić, Ana V.
AU  - Petrović, Sandra
AU  - Joksić, Gordana
AU  - Bugarcic, Zivadin
AU  - Vasić, Vesna M.
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5539
AB  - The in vitro influence of gold(III) complexes, H[AuCl4], [Au(DMSO)(2)Cl-2]Cl and [Au(bipy)Cl-2]Cl (bipy = 2,2-bipyridine), upon commercially available Na+ /K+ ATPase activity, purified from porcine brain cortex, was investigated. Additionally, the complexes were tested on human lymphocytes, and incidence of micronuclei and cell proliferation index was determined. Concentration-dependent inhibition of the enzyme for all three compounds was obtained, but with differing potencies. Calculated IC50 from Hill analysis were (in M): 5.75 x 10(-7), 5.50 x 10(-6) and 3.98 x 10(-5), for H[AuCl4], [Au(DMSO)(2)Cl-2]Cl and [Au(bipy)Cl-2]Cl, respectively, while Hill coefficient values, n, were above 1 in all cases. This inhibition can be prevented using -SH donating ligands such as L-Cys and glutathione, and these ligands can also cause a recovery of the enzyme activity after the induced inhibition. Kinetic analysis demonstrated that each of the studied gold(III) complexes affects Na+ /K+ ATPase reducing maximum enzymatic velocity, V-max, but not significantly changing the affinity for the substrate (K-M value), implying a noncompetitive mode of the interaction. Furthermore, among investigated gold(III) complexes, the [Au(bipy)Cl-2]Cl complex exhibits a strong cytotoxic effect on human lymphocytes, which suggests its potential for use in antitumor therapy. (C(C) 2013 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - In vitro effects of some gold complexes on Na+/K+ ATPase activity and cell proliferation
VL  - 124
SP  - 35
EP  - 41
DO  - 10.1016/j.jinorgbio.2013.03.013
ER  - 
@article{
author = "Petrovic, Voin and Čolović, Mirjana B. and Krstić, Danijela Z. and Vujačić, Ana V. and Petrović, Sandra and Joksić, Gordana and Bugarcic, Zivadin and Vasić, Vesna M.",
year = "2013",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/5539",
abstract = "The in vitro influence of gold(III) complexes, H[AuCl4], [Au(DMSO)(2)Cl-2]Cl and [Au(bipy)Cl-2]Cl (bipy = 2,2-bipyridine), upon commercially available Na+ /K+ ATPase activity, purified from porcine brain cortex, was investigated. Additionally, the complexes were tested on human lymphocytes, and incidence of micronuclei and cell proliferation index was determined. Concentration-dependent inhibition of the enzyme for all three compounds was obtained, but with differing potencies. Calculated IC50 from Hill analysis were (in M): 5.75 x 10(-7), 5.50 x 10(-6) and 3.98 x 10(-5), for H[AuCl4], [Au(DMSO)(2)Cl-2]Cl and [Au(bipy)Cl-2]Cl, respectively, while Hill coefficient values, n, were above 1 in all cases. This inhibition can be prevented using -SH donating ligands such as L-Cys and glutathione, and these ligands can also cause a recovery of the enzyme activity after the induced inhibition. Kinetic analysis demonstrated that each of the studied gold(III) complexes affects Na+ /K+ ATPase reducing maximum enzymatic velocity, V-max, but not significantly changing the affinity for the substrate (K-M value), implying a noncompetitive mode of the interaction. Furthermore, among investigated gold(III) complexes, the [Au(bipy)Cl-2]Cl complex exhibits a strong cytotoxic effect on human lymphocytes, which suggests its potential for use in antitumor therapy. (C(C) 2013 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "In vitro effects of some gold complexes on Na+/K+ ATPase activity and cell proliferation",
volume = "124",
pages = "35-41",
doi = "10.1016/j.jinorgbio.2013.03.013"
}
Petrovic, V., Čolović, M. B., Krstić, D. Z., Vujačić, A. V., Petrović, S., Joksić, G., Bugarcic, Z.,& Vasić, V. M. (2013). In vitro effects of some gold complexes on Na+/K+ ATPase activity and cell proliferation.
Journal of Inorganic Biochemistry, 124, 35-41.
https://doi.org/10.1016/j.jinorgbio.2013.03.013
Petrovic V, Čolović MB, Krstić DZ, Vujačić AV, Petrović S, Joksić G, Bugarcic Z, Vasić VM. In vitro effects of some gold complexes on Na+/K+ ATPase activity and cell proliferation. Journal of Inorganic Biochemistry. 2013;124:35-41
Petrovic Voin, Čolović Mirjana B., Krstić Danijela Z., Vujačić Ana V., Petrović Sandra, Joksić Gordana, Bugarcic Zivadin, Vasić Vesna M., "In vitro effects of some gold complexes on Na+/K+ ATPase activity and cell proliferation" Journal of Inorganic Biochemistry, 124 (2013):35-41,
https://doi.org/10.1016/j.jinorgbio.2013.03.013 .
11
11
9

Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)

Vucic, D. A.; Nikezić, Dragoslav; Vaupotič, Janja; Stojanovska, Zdenka A.; Krstić, Danijela Z.; Žunić, Zora S.

(2013)

TY  - JOUR
AU  - Vucic, D. A.
AU  - Nikezić, Dragoslav
AU  - Vaupotič, Janja
AU  - Stojanovska, Zdenka A.
AU  - Krstić, Danijela Z.
AU  - Žunić, Zora S.
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7002
AB  - This paper deals with calculated effective doses that members of real population received from radon gas and its short lived progeny during air inhalation in their dwellings at field site Kalna in Eastern Serbia. There are two crucial parameters in effective dose calculation: Dose Conversion Factor (DCF) for particular subjects (including real gender, age and physical activity level) and indoor concentration of radon and its short lived progeny in field area. According to the results of indoor radon measurements in the area of former uranium mine, Kalna, the effective dose for this real population was estimated by using the dosimetric lung model, developed by authors according ICRP Publication 66. Authentic software was developed for determination of effective dose per unit inhaled activity of radon progeny, DCF expressed in unit [mSv/WLM]. The results, obtained according to ICRP 66 dosimeter lung model, were compared with results calculated according to ICRP Publication 65. The dosimetric results were, also, compared and discussed with epidemiological approach data, according to UNSCEAR.
T2  - Romanian Journal of Physics
T1  - Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)
VL  - 58
SP  - S336
EP  - S347
ER  - 
@article{
author = "Vucic, D. A. and Nikezić, Dragoslav and Vaupotič, Janja and Stojanovska, Zdenka A. and Krstić, Danijela Z. and Žunić, Zora S.",
year = "2013",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7002",
abstract = "This paper deals with calculated effective doses that members of real population received from radon gas and its short lived progeny during air inhalation in their dwellings at field site Kalna in Eastern Serbia. There are two crucial parameters in effective dose calculation: Dose Conversion Factor (DCF) for particular subjects (including real gender, age and physical activity level) and indoor concentration of radon and its short lived progeny in field area. According to the results of indoor radon measurements in the area of former uranium mine, Kalna, the effective dose for this real population was estimated by using the dosimetric lung model, developed by authors according ICRP Publication 66. Authentic software was developed for determination of effective dose per unit inhaled activity of radon progeny, DCF expressed in unit [mSv/WLM]. The results, obtained according to ICRP 66 dosimeter lung model, were compared with results calculated according to ICRP Publication 65. The dosimetric results were, also, compared and discussed with epidemiological approach data, according to UNSCEAR.",
journal = "Romanian Journal of Physics",
title = "Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)",
volume = "58",
pages = "S336-S347"
}
Vucic, D. A., Nikezić, D., Vaupotič, J., Stojanovska, Z. A., Krstić, D. Z.,& Žunić, Z. S. (2013). Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia).
Romanian Journal of Physics, 58, S336-S347.
Vucic DA, Nikezić D, Vaupotič J, Stojanovska ZA, Krstić DZ, Žunić ZS. Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia). Romanian Journal of Physics. 2013;58:S336-S347
Vucic D. A., Nikezić Dragoslav, Vaupotič Janja, Stojanovska Zdenka A., Krstić Danijela Z., Žunić Zora S., "Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)" Romanian Journal of Physics, 58 (2013):S336-S347
1

Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation

Mladenovic, Dusan; Krstić, Danijela Z.; Čolović, Mirjana B.; Radosavljevic, Tatjana; Rasic-Markovic, Aleksandra; Hrncic, Dragan; Macut, Djuro; Stanojlovic, Olivera

(2012)

TY  - JOUR
AU  - Mladenovic, Dusan
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Radosavljevic, Tatjana
AU  - Rasic-Markovic, Aleksandra
AU  - Hrncic, Dragan
AU  - Macut, Djuro
AU  - Stanojlovic, Olivera
PY  - 2012
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4696
AB  - Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.
T2  - Medicinal Chemistry
T1  - Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation
VL  - 8
IS  - 1
SP  - 52
EP  - 58
DO  - 10.2174/157340612799278603
ER  - 
@article{
author = "Mladenovic, Dusan and Krstić, Danijela Z. and Čolović, Mirjana B. and Radosavljevic, Tatjana and Rasic-Markovic, Aleksandra and Hrncic, Dragan and Macut, Djuro and Stanojlovic, Olivera",
year = "2012",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/4696",
abstract = "Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.",
journal = "Medicinal Chemistry",
title = "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation",
volume = "8",
number = "1",
pages = "52-58",
doi = "10.2174/157340612799278603"
}
Mladenovic, D., Krstić, D. Z., Čolović, M. B., Radosavljevic, T., Rasic-Markovic, A., Hrncic, D., Macut, D.,& Stanojlovic, O. (2012). Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation.
Medicinal Chemistry, 8(1), 52-58.
https://doi.org/10.2174/157340612799278603
Mladenovic D, Krstić DZ, Čolović MB, Radosavljevic T, Rasic-Markovic A, Hrncic D, Macut D, Stanojlovic O. Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation. Medicinal Chemistry. 2012;8(1):52-58
Mladenovic Dusan, Krstić Danijela Z., Čolović Mirjana B., Radosavljevic Tatjana, Rasic-Markovic Aleksandra, Hrncic Dragan, Macut Djuro, Stanojlovic Olivera, "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation" Medicinal Chemistry, 8, no. 1 (2012):52-58,
https://doi.org/10.2174/157340612799278603 .
8
7
7

Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury

Brkic, Predrag; Jovanovic, Tomislav; Krstić, Danijela Z.; Stojiljković, Mirjana; Čolović, Mirjana B.; Dacic, Sanja; Mitrovic, Ana; Bjelaobaba, Ivana; Savić, Danijela; Parbucki, Ana; Lavrnja, Irena; Rakic, Ljubisav; Pekovic, Sanja

(2012)

TY  - CONF
AU  - Brkic, Predrag
AU  - Jovanovic, Tomislav
AU  - Krstić, Danijela Z.
AU  - Stojiljković, Mirjana
AU  - Čolović, Mirjana B.
AU  - Dacic, Sanja
AU  - Mitrovic, Ana
AU  - Bjelaobaba, Ivana
AU  - Savić, Danijela
AU  - Parbucki, Ana
AU  - Lavrnja, Irena
AU  - Rakic, Ljubisav
AU  - Pekovic, Sanja
PY  - 2012
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4847
C3  - Brain Injury
T1  - Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury
VL  - 26
IS  - 4-5
SP  - 486
EP  - 487
ER  - 
@conference{
author = "Brkic, Predrag and Jovanovic, Tomislav and Krstić, Danijela Z. and Stojiljković, Mirjana and Čolović, Mirjana B. and Dacic, Sanja and Mitrovic, Ana and Bjelaobaba, Ivana and Savić, Danijela and Parbucki, Ana and Lavrnja, Irena and Rakic, Ljubisav and Pekovic, Sanja",
year = "2012",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/4847",
journal = "Brain Injury",
title = "Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury",
volume = "26",
number = "4-5",
pages = "486-487"
}
Brkic, P., Jovanovic, T., Krstić, D. Z., Stojiljković, M., Čolović, M. B., Dacic, S., Mitrovic, A., Bjelaobaba, I., Savić, D., Parbucki, A., Lavrnja, I., Rakic, L.,& Pekovic, S. (2012). Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury.
Brain Injury, 26(4-5), 486-487.
Brkic P, Jovanovic T, Krstić DZ, Stojiljković M, Čolović MB, Dacic S, Mitrovic A, Bjelaobaba I, Savić D, Parbucki A, Lavrnja I, Rakic L, Pekovic S. Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury. Brain Injury. 2012;26(4-5):486-487
Brkic Predrag, Jovanovic Tomislav, Krstić Danijela Z., Stojiljković Mirjana, Čolović Mirjana B., Dacic Sanja, Mitrovic Ana, Bjelaobaba Ivana, Savić Danijela, Parbucki Ana, Lavrnja Irena, Rakic Ljubisav, Pekovic Sanja, "Hyperbaric oxygenation reduces neuronal degeneration by regulation of oxidant/antioxidant status in the rat brain tissue after cortical injury" Brain Injury, 26, no. 4-5 (2012):486-487