TY  - JOUR
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/815
AB  - Purpose Previously, we examined manganese superoxide dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT) activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The results indicated that lower MnSOD activity and inducibility found in hippocampus might explain higher radiosensitivity of this brain region. Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD, and CAT activities after dose of 5 Gy and to find out if differences in MnSOD activity are caused by changes in its expression. Heads of 4-day-old female rats were irradiated with gamma-rays, using Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and cortex tissues were prepared for enzyme activity measurements and Western blot analysis. One hour after exposure, gamma-rays significantly decreased MnSOD activity in both examined brain regions. Twenty-four hours later, MnSOD recovery showed dose and regional dependence. It was weaker at higher doses and in hippocampal region. MnSOD expression changed in the similar manner as MnSOD activity only at lower doses of gamma-rays. In both examined brain regions, gamma radiation significantly decreased CuZnSOD activity and did not change activity of CAT. Our results confirmed that MnSOD plays an important role in different regional radiosensitivity but also showed that depending on dose, radiation affects MnSOD level by utterly different mechanisms. Postradiation changes of CuZnSOD and CAT are not regionally specific and therefore, cannot account for the different radiosensitivity of the hippocampus and cortex.
PB  - Springer Nature
T2  - Childs Nervous System
T1  - Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity
VL  - 31
IS  - 12
SP  - 2249
EP  - 2256
DO  - 10.1007/s00381-015-2807-2
ER  - 

@article{
author = "Todorović, Ana and Pejić, Snežana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Saičić, Zorica S. and Pajović, Snežana B.",
year = "2015",
abstract = "Purpose Previously, we examined manganese superoxide dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT) activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The results indicated that lower MnSOD activity and inducibility found in hippocampus might explain higher radiosensitivity of this brain region. Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD, and CAT activities after dose of 5 Gy and to find out if differences in MnSOD activity are caused by changes in its expression. Heads of 4-day-old female rats were irradiated with gamma-rays, using Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and cortex tissues were prepared for enzyme activity measurements and Western blot analysis. One hour after exposure, gamma-rays significantly decreased MnSOD activity in both examined brain regions. Twenty-four hours later, MnSOD recovery showed dose and regional dependence. It was weaker at higher doses and in hippocampal region. MnSOD expression changed in the similar manner as MnSOD activity only at lower doses of gamma-rays. In both examined brain regions, gamma radiation significantly decreased CuZnSOD activity and did not change activity of CAT. Our results confirmed that MnSOD plays an important role in different regional radiosensitivity but also showed that depending on dose, radiation affects MnSOD level by utterly different mechanisms. Postradiation changes of CuZnSOD and CAT are not regionally specific and therefore, cannot account for the different radiosensitivity of the hippocampus and cortex.",
publisher = "Springer Nature",
journal = "Childs Nervous System",
title = "Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity",
volume = "31",
number = "12",
pages = "2249-2256",
doi = "10.1007/s00381-015-2807-2"
}

Todorović, A., Pejić, S., Stojiljković, V., Gavrilović, L., Popović, N. M., Pavlović, I., Saičić, Z. S.,& Pajović, S. B.. (2015). Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity. in Childs Nervous System
Springer Nature., 31(12), 2249-2256.
https://doi.org/10.1007/s00381-015-2807-2

Todorović A, Pejić S, Stojiljković V, Gavrilović L, Popović NM, Pavlović I, Saičić ZS, Pajović SB. Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity. in Childs Nervous System. 2015;31(12):2249-2256.
doi:10.1007/s00381-015-2807-2 .

Todorović, Ana, Pejić, Snežana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pavlović, Ivan, Saičić, Zorica S., Pajović, Snežana B., "Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity" in Childs Nervous System, 31, no. 12 (2015):2249-2256,
https://doi.org/10.1007/s00381-015-2807-2 . .

TY  - JOUR
AU  - Perendija, Branka R.
AU  - Despotović, Svetlana G.
AU  - Radovanovic, Tijana B.
AU  - Gavric, Jelena P.
AU  - Mitić, Slavica S. Borkovic
AU  - Pavlović, Slađan
AU  - Ognjanovic, Branka I.
AU  - Simic, Snezana B.
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4652
AB  - We investigated the biochemical and ultrastructural changes in the liver of the freshwater fish, European perch (Perca fluviatilis), in response to Aphanizomenon flos-aquae bloom in the Gruza Reservoir, Serbia. The activities of total manganese- and copper zinc-containing superoxide dismutase (Tot SOD, Mn-SOD, Cu/Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST), as well as concentrations of total glutathione (GSH) and sulfhydryl (-SH) groups were examined before and during the bloom period. Mn-SOD activity was significantly higher, while the activities of Cu/Zn-SOD, CAT and GSH-Px and the concentration of the -SH groups were significantly lower during the bloom. The ultrastructure of the liver revealed necrotic and apoptotic damage to the hepatocytes during the bloom period. Our work represents the first study to report the influences of an Aphanizomenon flos-aquae bloom in the Gruza Reservoir on antioxidant biomarkers and on histopathological alterations in the liver of the freshwater fish European perch (Perca fluviatilis).
T2  - Archives of Biological Sciences
T1  - Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir
VL  - 63
IS  - 4
SP  - 979
EP  - 989
DO  - 10.2298/ABS1104979P
ER  - 

@article{
author = "Perendija, Branka R. and Despotović, Svetlana G. and Radovanovic, Tijana B. and Gavric, Jelena P. and Mitić, Slavica S. Borkovic and Pavlović, Slađan and Ognjanovic, Branka I. and Simic, Snezana B. and Pajović, Snežana B. and Saičić, Zorica S.",
year = "2011",
abstract = "We investigated the biochemical and ultrastructural changes in the liver of the freshwater fish, European perch (Perca fluviatilis), in response to Aphanizomenon flos-aquae bloom in the Gruza Reservoir, Serbia. The activities of total manganese- and copper zinc-containing superoxide dismutase (Tot SOD, Mn-SOD, Cu/Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST), as well as concentrations of total glutathione (GSH) and sulfhydryl (-SH) groups were examined before and during the bloom period. Mn-SOD activity was significantly higher, while the activities of Cu/Zn-SOD, CAT and GSH-Px and the concentration of the -SH groups were significantly lower during the bloom. The ultrastructure of the liver revealed necrotic and apoptotic damage to the hepatocytes during the bloom period. Our work represents the first study to report the influences of an Aphanizomenon flos-aquae bloom in the Gruza Reservoir on antioxidant biomarkers and on histopathological alterations in the liver of the freshwater fish European perch (Perca fluviatilis).",
journal = "Archives of Biological Sciences",
title = "Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir",
volume = "63",
number = "4",
pages = "979-989",
doi = "10.2298/ABS1104979P"
}

Perendija, B. R., Despotović, S. G., Radovanovic, T. B., Gavric, J. P., Mitić, S. S. B., Pavlović, S., Ognjanovic, B. I., Simic, S. B., Pajović, S. B.,& Saičić, Z. S.. (2011). Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir. in Archives of Biological Sciences, 63(4), 979-989.
https://doi.org/10.2298/ABS1104979P

Perendija BR, Despotović SG, Radovanovic TB, Gavric JP, Mitić SSB, Pavlović S, Ognjanovic BI, Simic SB, Pajović SB, Saičić ZS. Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir. in Archives of Biological Sciences. 2011;63(4):979-989.
doi:10.2298/ABS1104979P .

Perendija, Branka R., Despotović, Svetlana G., Radovanovic, Tijana B., Gavric, Jelena P., Mitić, Slavica S. Borkovic, Pavlović, Slađan, Ognjanovic, Branka I., Simic, Snezana B., Pajović, Snežana B., Saičić, Zorica S., "Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir" in Archives of Biological Sciences, 63, no. 4 (2011):979-989,
https://doi.org/10.2298/ABS1104979P . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Radosevic-Jelic, Ljiljana
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4107
AB  - Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p LT 0.05) and decreased AO enzyme activities (CuZnSOD: p LT 0.01, GPx: p LT 0.05, GR: p LT 0.01) and GSH level (p LT 0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p LT 0.05), while it increased after the radiotherapy of breast cancer (p LT 0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H2O2 detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide
VL  - 43
IS  - 16-17
SP  - 1287
EP  - 1293
DO  - 10.1016/j.clinbiochem.2010.08.009
ER  - 

@article{
author = "Kasapović, Jelena and Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Radosevic-Jelic, Ljiljana and Saičić, Zorica S. and Pajović, Snežana B.",
year = "2010",
abstract = "Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p LT 0.05) and decreased AO enzyme activities (CuZnSOD: p LT 0.01, GPx: p LT 0.05, GR: p LT 0.01) and GSH level (p LT 0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p LT 0.05), while it increased after the radiotherapy of breast cancer (p LT 0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H2O2 detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide",
volume = "43",
number = "16-17",
pages = "1287-1293",
doi = "10.1016/j.clinbiochem.2010.08.009"
}

Kasapović, J., Pejić, S., Stojiljković, V., Todorović, A., Radosevic-Jelic, L., Saičić, Z. S.,& Pajović, S. B.. (2010). Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry, 43(16-17), 1287-1293.
https://doi.org/10.1016/j.clinbiochem.2010.08.009

Kasapović J, Pejić S, Stojiljković V, Todorović A, Radosevic-Jelic L, Saičić ZS, Pajović SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry. 2010;43(16-17):1287-1293.
doi:10.1016/j.clinbiochem.2010.08.009 .

Kasapović, Jelena, Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Radosevic-Jelic, Ljiljana, Saičić, Zorica S., Pajović, Snežana B., "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide" in Clinical Biochemistry, 43, no. 16-17 (2010):1287-1293,
https://doi.org/10.1016/j.clinbiochem.2010.08.009 . .

TY  - JOUR
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Saičić, Zorica S.
AU  - Radlovic, Nedeljko
AU  - Pajović, Snežana B.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3836
AB  - Objective: To explain the role of oxidative stress in the pathology of celiac disease. Design and methods: The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects. Results: The activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups. Conclusions: Oxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease
VL  - 42
IS  - 13-14
SP  - 1431
EP  - 1437
DO  - 10.1016/j.clinbiochem.2009.06.009
ER  - 

@article{
author = "Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Kasapović, Jelena and Saičić, Zorica S. and Radlovic, Nedeljko and Pajović, Snežana B.",
year = "2009",
abstract = "Objective: To explain the role of oxidative stress in the pathology of celiac disease. Design and methods: The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects. Results: The activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups. Conclusions: Oxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease",
volume = "42",
number = "13-14",
pages = "1431-1437",
doi = "10.1016/j.clinbiochem.2009.06.009"
}

Stojiljković, V., Todorović, A., Pejić, S., Kasapović, J., Saičić, Z. S., Radlovic, N.,& Pajović, S. B.. (2009). Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. in Clinical Biochemistry, 42(13-14), 1431-1437.
https://doi.org/10.1016/j.clinbiochem.2009.06.009

Stojiljković V, Todorović A, Pejić S, Kasapović J, Saičić ZS, Radlovic N, Pajović SB. Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. in Clinical Biochemistry. 2009;42(13-14):1431-1437.
doi:10.1016/j.clinbiochem.2009.06.009 .

Stojiljković, Vesna, Todorović, Ana, Pejić, Snežana, Kasapović, Jelena, Saičić, Zorica S., Radlovic, Nedeljko, Pajović, Snežana B., "Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease" in Clinical Biochemistry, 42, no. 13-14 (2009):1431-1437,
https://doi.org/10.1016/j.clinbiochem.2009.06.009 . .

TY  - JOUR
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3241
AB  - The sex steroids produce their effects by acting on numerous target tissues and organs, such as the reproductive organs, bone tissue and cartilage, peripheral blood vessels as well as the central nervous system (CNS). In our studies we have monitored the change of enzyme activity of the antioxidant (AO) system in the brain of female rats depending on the ovarian steroids. We have chosen it as a new parameter that might represent an important indicator of the changes within the CNS, bearing in mind the biological importance of the enzymes of the AO system. The experimental results of our study indicate that the enzyme activity of the AO system in the brain tissue of female rats shows a certain dependence on the concentration of ovarian hormones, progesterone and estradiol, in the organism. Study of the activity of the enzymes of the AO system in the brain of female rats depending on the influence of ovarian hormones can answer whether the action of ovarian steroids on the CNS includes maintenance of a dynamic equilibrium of free radicals in the neurons.
T2  - Periodicum Biologorum
T1  - Regulation of antioxidant enzyme activities in female rat brain by ovarian steroids
VL  - 110
IS  - 1
SP  - 31
EP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3241
ER  - 

@article{
author = "Pajović, Snežana B. and Saičić, Zorica S.",
year = "2008",
abstract = "The sex steroids produce their effects by acting on numerous target tissues and organs, such as the reproductive organs, bone tissue and cartilage, peripheral blood vessels as well as the central nervous system (CNS). In our studies we have monitored the change of enzyme activity of the antioxidant (AO) system in the brain of female rats depending on the ovarian steroids. We have chosen it as a new parameter that might represent an important indicator of the changes within the CNS, bearing in mind the biological importance of the enzymes of the AO system. The experimental results of our study indicate that the enzyme activity of the AO system in the brain tissue of female rats shows a certain dependence on the concentration of ovarian hormones, progesterone and estradiol, in the organism. Study of the activity of the enzymes of the AO system in the brain of female rats depending on the influence of ovarian hormones can answer whether the action of ovarian steroids on the CNS includes maintenance of a dynamic equilibrium of free radicals in the neurons.",
journal = "Periodicum Biologorum",
title = "Regulation of antioxidant enzyme activities in female rat brain by ovarian steroids",
volume = "110",
number = "1",
pages = "31-34",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3241"
}

Pajović, S. B.,& Saičić, Z. S.. (2008). Regulation of antioxidant enzyme activities in female rat brain by ovarian steroids. in Periodicum Biologorum, 110(1), 31-34.
https://hdl.handle.net/21.15107/rcub_vinar_3241

Pajović SB, Saičić ZS. Regulation of antioxidant enzyme activities in female rat brain by ovarian steroids. in Periodicum Biologorum. 2008;110(1):31-34.
https://hdl.handle.net/21.15107/rcub_vinar_3241 .

Pajović, Snežana B., Saičić, Zorica S., "Regulation of antioxidant enzyme activities in female rat brain by ovarian steroids" in Periodicum Biologorum, 110, no. 1 (2008):31-34,
https://hdl.handle.net/21.15107/rcub_vinar_3241 .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Cvetković, Dragana
AU  - Lucic, Nenad
AU  - Radojicic, Ratko M.
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3520
AB  - Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosis. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications.
T2  - Anais de Academia Brasileira de Ciencias
T1  - Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium
VL  - 80
IS  - 3
SP  - 515
EP  - 522
DO  - 10.1590/S0001-37652008000300011
ER  - 

@article{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Cvetković, Dragana and Lucic, Nenad and Radojicic, Ratko M. and Saičić, Zorica S. and Pajović, Snežana B.",
year = "2008",
abstract = "Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosis. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications.",
journal = "Anais de Academia Brasileira de Ciencias",
title = "Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium",
volume = "80",
number = "3",
pages = "515-522",
doi = "10.1590/S0001-37652008000300011"
}

Pejić, S., Todorović, A., Stojiljković, V., Cvetković, D., Lucic, N., Radojicic, R. M., Saičić, Z. S.,& Pajović, S. B.. (2008). Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. in Anais de Academia Brasileira de Ciencias, 80(3), 515-522.
https://doi.org/10.1590/S0001-37652008000300011

Pejić S, Todorović A, Stojiljković V, Cvetković D, Lucic N, Radojicic RM, Saičić ZS, Pajović SB. Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. in Anais de Academia Brasileira de Ciencias. 2008;80(3):515-522.
doi:10.1590/S0001-37652008000300011 .

Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Cvetković, Dragana, Lucic, Nenad, Radojicic, Ratko M., Saičić, Zorica S., Pajović, Snežana B., "Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium" in Anais de Academia Brasileira de Ciencias, 80, no. 3 (2008):515-522,
https://doi.org/10.1590/S0001-37652008000300011 . .

TY  - JOUR
AU  - Perendija, Branka R.
AU  - Borković, Slavica S.
AU  - Kovačević, Tijana B.
AU  - Pavlović, Slađan
AU  - Stojanović, Bojana D.
AU  - Paunović, M. M.
AU  - Cakić, P. D.
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3415
T2  - Archives of Biological Sciences
T1  - Activities of superoxide dismutase and catalase in the foot of three freshwater mussel species.
VL  - 59
IS  - 2
SP  - 17P
EP  - 18P
DO  - 10.2298/ABS0702001P
ER  - 

@article{
author = "Perendija, Branka R. and Borković, Slavica S. and Kovačević, Tijana B. and Pavlović, Slađan and Stojanović, Bojana D. and Paunović, M. M. and Cakić, P. D. and Pajović, Snežana B. and Saičić, Zorica S.",
year = "2007",
journal = "Archives of Biological Sciences",
title = "Activities of superoxide dismutase and catalase in the foot of three freshwater mussel species.",
volume = "59",
number = "2",
pages = "17P-18P",
doi = "10.2298/ABS0702001P"
}

Perendija, B. R., Borković, S. S., Kovačević, T. B., Pavlović, S., Stojanović, B. D., Paunović, M. M., Cakić, P. D., Pajović, S. B.,& Saičić, Z. S.. (2007). Activities of superoxide dismutase and catalase in the foot of three freshwater mussel species.. in Archives of Biological Sciences, 59(2), 17P-18P.
https://doi.org/10.2298/ABS0702001P

Perendija BR, Borković SS, Kovačević TB, Pavlović S, Stojanović BD, Paunović MM, Cakić PD, Pajović SB, Saičić ZS. Activities of superoxide dismutase and catalase in the foot of three freshwater mussel species.. in Archives of Biological Sciences. 2007;59(2):17P-18P.
doi:10.2298/ABS0702001P .

Perendija, Branka R., Borković, Slavica S., Kovačević, Tijana B., Pavlović, Slađan, Stojanović, Bojana D., Paunović, M. M., Cakić, P. D., Pajović, Snežana B., Saičić, Zorica S., "Activities of superoxide dismutase and catalase in the foot of three freshwater mussel species." in Archives of Biological Sciences, 59, no. 2 (2007):17P-18P,
https://doi.org/10.2298/ABS0702001P . .

TY  - JOUR
AU  - Despotović, Svetlana G.
AU  - Perendija, Branka R.
AU  - Kovačević, Tijana B.
AU  - Borković, Slavica S.
AU  - Pavlović, Slađan
AU  - Milošević, S. M.
AU  - Đikanović, Vesna D.
AU  - Cakić, P. D.
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica. S.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3420
T2  - Archives of Biological Sciences
T1  - Glutathione redox status in some tissues and the intestinal parasite Pomphorhynchus laevis (Acanthocephala) from barbel (Barbus barbus) (pisces) from the Danube river
VL  - 59
IS  - 4
SP  - 57P
EP  - 58P
DO  - 10.2298/ABS0704057D
ER  - 

@article{
author = "Despotović, Svetlana G. and Perendija, Branka R. and Kovačević, Tijana B. and Borković, Slavica S. and Pavlović, Slađan and Milošević, S. M. and Đikanović, Vesna D. and Cakić, P. D. and Pajović, Snežana B. and Saičić, Zorica. S.",
year = "2007",
journal = "Archives of Biological Sciences",
title = "Glutathione redox status in some tissues and the intestinal parasite Pomphorhynchus laevis (Acanthocephala) from barbel (Barbus barbus) (pisces) from the Danube river",
volume = "59",
number = "4",
pages = "57P-58P",
doi = "10.2298/ABS0704057D"
}

Despotović, S. G., Perendija, B. R., Kovačević, T. B., Borković, S. S., Pavlović, S., Milošević, S. M., Đikanović, V. D., Cakić, P. D., Pajović, S. B.,& Saičić, Zorica. S.. (2007). Glutathione redox status in some tissues and the intestinal parasite Pomphorhynchus laevis (Acanthocephala) from barbel (Barbus barbus) (pisces) from the Danube river. in Archives of Biological Sciences, 59(4), 57P-58P.
https://doi.org/10.2298/ABS0704057D

Despotović SG, Perendija BR, Kovačević TB, Borković SS, Pavlović S, Milošević SM, Đikanović VD, Cakić PD, Pajović SB, Saičić ZS. Glutathione redox status in some tissues and the intestinal parasite Pomphorhynchus laevis (Acanthocephala) from barbel (Barbus barbus) (pisces) from the Danube river. in Archives of Biological Sciences. 2007;59(4):57P-58P.
doi:10.2298/ABS0704057D .

Despotović, Svetlana G., Perendija, Branka R., Kovačević, Tijana B., Borković, Slavica S., Pavlović, Slađan, Milošević, S. M., Đikanović, Vesna D., Cakić, P. D., Pajović, Snežana B., Saičić, Zorica. S., "Glutathione redox status in some tissues and the intestinal parasite Pomphorhynchus laevis (Acanthocephala) from barbel (Barbus barbus) (pisces) from the Danube river" in Archives of Biological Sciences, 59, no. 4 (2007):57P-58P,
https://doi.org/10.2298/ABS0704057D . .

TY  - JOUR
AU  - Perendija, Branka R.
AU  - Borković, Slavica S.
AU  - Kovačević, Tijana B.
AU  - Pavlović, Slađan
AU  - Stojanović, Bojana D.
AU  - Paunović, M. M.
AU  - Cakić, P. D.
AU  - Radojičić, R. M.
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3416
AB  - We investigated activities of glutathione peroxidase (GSH-Px), glutathione reductase (GR), and the phase II biotransfomation enzyme glutathione-S-transferase (GST) in the foot of three freshwater mussel species: Unio pictorum (Up), Unio tumidus (Ut), and Sinanodonta woodiana (Sw) from the Sava River. Specific and total GSH-Px activity was lower in Sw than in Up and Ut. Total GR activity was higher in Up than in Sw. Specific GST activity was higher in Up than in Ut. Total GST activity was higher in Up than in Ut and Sw. Electrophoretic analysis of proteins shows species specifities between the investigated mussel species. Our study represents the first comprehensive report of the investigated glutathione-dependent enzyme activities in the foot of three freshwater mussel species from the Sava River, Serbia.
T2  - Archives of Biological Sciences
T1  - Glutathione dependent enzyme activities in the foot of three freshwater mussel species in the Sava River, Serbia
VL  - 59
IS  - 3
SP  - 169
EP  - 175
DO  - 10.2298/ABS0703169P
ER  - 

@article{
author = "Perendija, Branka R. and Borković, Slavica S. and Kovačević, Tijana B. and Pavlović, Slađan and Stojanović, Bojana D. and Paunović, M. M. and Cakić, P. D. and Radojičić, R. M. and Pajović, Snežana B. and Saičić, Zorica S.",
year = "2007",
abstract = "We investigated activities of glutathione peroxidase (GSH-Px), glutathione reductase (GR), and the phase II biotransfomation enzyme glutathione-S-transferase (GST) in the foot of three freshwater mussel species: Unio pictorum (Up), Unio tumidus (Ut), and Sinanodonta woodiana (Sw) from the Sava River. Specific and total GSH-Px activity was lower in Sw than in Up and Ut. Total GR activity was higher in Up than in Sw. Specific GST activity was higher in Up than in Ut. Total GST activity was higher in Up than in Ut and Sw. Electrophoretic analysis of proteins shows species specifities between the investigated mussel species. Our study represents the first comprehensive report of the investigated glutathione-dependent enzyme activities in the foot of three freshwater mussel species from the Sava River, Serbia.",
journal = "Archives of Biological Sciences",
title = "Glutathione dependent enzyme activities in the foot of three freshwater mussel species in the Sava River, Serbia",
volume = "59",
number = "3",
pages = "169-175",
doi = "10.2298/ABS0703169P"
}

Perendija, B. R., Borković, S. S., Kovačević, T. B., Pavlović, S., Stojanović, B. D., Paunović, M. M., Cakić, P. D., Radojičić, R. M., Pajović, S. B.,& Saičić, Z. S.. (2007). Glutathione dependent enzyme activities in the foot of three freshwater mussel species in the Sava River, Serbia. in Archives of Biological Sciences, 59(3), 169-175.
https://doi.org/10.2298/ABS0703169P

Perendija BR, Borković SS, Kovačević TB, Pavlović S, Stojanović BD, Paunović MM, Cakić PD, Radojičić RM, Pajović SB, Saičić ZS. Glutathione dependent enzyme activities in the foot of three freshwater mussel species in the Sava River, Serbia. in Archives of Biological Sciences. 2007;59(3):169-175.
doi:10.2298/ABS0703169P .

Perendija, Branka R., Borković, Slavica S., Kovačević, Tijana B., Pavlović, Slađan, Stojanović, Bojana D., Paunović, M. M., Cakić, P. D., Radojičić, R. M., Pajović, Snežana B., Saičić, Zorica S., "Glutathione dependent enzyme activities in the foot of three freshwater mussel species in the Sava River, Serbia" in Archives of Biological Sciences, 59, no. 3 (2007):169-175,
https://doi.org/10.2298/ABS0703169P . .