TY  - JOUR
AU  - Marinković, Valentina D.
AU  - Agbaba, Danica
AU  - Karjikovic-Rajic, K
AU  - Vladimirov, Sote
AU  - Nedeljković, Jovan
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6377
AB  - The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Photochemical degradation of solid-state nisoldipine monitored by HPLC
VL  - 32
IS  - 4-5
SP  - 929
EP  - 935
DO  - 10.1016/S0731-7085(03)00194-8
ER  - 

@article{
author = "Marinković, Valentina D. and Agbaba, Danica and Karjikovic-Rajic, K and Vladimirov, Sote and Nedeljković, Jovan",
year = "2003",
abstract = "The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Photochemical degradation of solid-state nisoldipine monitored by HPLC",
volume = "32",
number = "4-5",
pages = "929-935",
doi = "10.1016/S0731-7085(03)00194-8"
}

Marinković, V. D., Agbaba, D., Karjikovic-Rajic, K., Vladimirov, S.,& Nedeljković, J.. (2003). Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 929-935.
https://doi.org/10.1016/S0731-7085(03)00194-8

Marinković VD, Agbaba D, Karjikovic-Rajic K, Vladimirov S, Nedeljković J. Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):929-935.
doi:10.1016/S0731-7085(03)00194-8 .

Marinković, Valentina D., Agbaba, Danica, Karjikovic-Rajic, K, Vladimirov, Sote, Nedeljković, Jovan, "Photochemical degradation of solid-state nisoldipine monitored by HPLC" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):929-935,
https://doi.org/10.1016/S0731-7085(03)00194-8 . .