TY  - JOUR
AU  - Radović, Magdalena
AU  - Vranješ-Đurić, Sanja
AU  - Nikolić, Nadežda S.
AU  - Janković, Drina
AU  - Goya, Gerardo F.
AU  - Torres, Teobaldo E.
AU  - Calatayud, Maria Pilar
AU  - Bruvera, Ignacio J.
AU  - Ibarra, M. Ricardo
AU  - Spasojević, Vojislav
AU  - Jančar, Boštjan
AU  - Antić, Bratislav
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5175
AB  - Radio labeled albumin microspheres with encapsulated citric acid-coated magnetite nanoparticles were developed as a targeting approach to localize both radioactivity and magnetic energy at the tumor site. We present in vitro and in vivo studies of yttrium-90 (Y-90)-labeled human scrum albumin magnetic microspheres (HSAMMS) as a multifunctional agent for possible applications in a bimodal radionuclide-hyperthermia cancer therapy. The HSAMMS were produced using a modified emulsification-heat stabilization technique and contained 11 nm magnetite nanoparticles coated with citric acid, distributed as inhomogeneous clusters within the albumin microspheres. The size, size distribution and the morphology of magnetite nanoparticles and HSAMMS were determined by FESEM, HRTEM and SEM/FIB dual beam. The average particle size of the complete HSAMMS was 20 mu m, and they exhibited superparamagnetic behavior at room temperature. The in vitro experiments (in saline and human serum) revealed the high stability of the labeled HSAMMS in saline and human serum after 72 h. Following the intravenous administration of the Y-90-HSAMMS in rats, 88.81% of the activity localizes in the lungs after 1 h, with 82.67% remaining after 72 h. These data on Y-90-HSAMMS provide good evidence for their potential use in bimodal radionuclide-hyperthermia cancer therapy.
T2  - Journal of Materials Chemistry
T1  - Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy
VL  - 22
IS  - 45
SP  - 24017
EP  - 24025
DO  - 10.1039/c2jm35593k
ER  - 

@article{
author = "Radović, Magdalena and Vranješ-Đurić, Sanja and Nikolić, Nadežda S. and Janković, Drina and Goya, Gerardo F. and Torres, Teobaldo E. and Calatayud, Maria Pilar and Bruvera, Ignacio J. and Ibarra, M. Ricardo and Spasojević, Vojislav and Jančar, Boštjan and Antić, Bratislav",
year = "2012",
abstract = "Radio labeled albumin microspheres with encapsulated citric acid-coated magnetite nanoparticles were developed as a targeting approach to localize both radioactivity and magnetic energy at the tumor site. We present in vitro and in vivo studies of yttrium-90 (Y-90)-labeled human scrum albumin magnetic microspheres (HSAMMS) as a multifunctional agent for possible applications in a bimodal radionuclide-hyperthermia cancer therapy. The HSAMMS were produced using a modified emulsification-heat stabilization technique and contained 11 nm magnetite nanoparticles coated with citric acid, distributed as inhomogeneous clusters within the albumin microspheres. The size, size distribution and the morphology of magnetite nanoparticles and HSAMMS were determined by FESEM, HRTEM and SEM/FIB dual beam. The average particle size of the complete HSAMMS was 20 mu m, and they exhibited superparamagnetic behavior at room temperature. The in vitro experiments (in saline and human serum) revealed the high stability of the labeled HSAMMS in saline and human serum after 72 h. Following the intravenous administration of the Y-90-HSAMMS in rats, 88.81% of the activity localizes in the lungs after 1 h, with 82.67% remaining after 72 h. These data on Y-90-HSAMMS provide good evidence for their potential use in bimodal radionuclide-hyperthermia cancer therapy.",
journal = "Journal of Materials Chemistry",
title = "Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy",
volume = "22",
number = "45",
pages = "24017-24025",
doi = "10.1039/c2jm35593k"
}

Radović, M., Vranješ-Đurić, S., Nikolić, N. S., Janković, D., Goya, G. F., Torres, T. E., Calatayud, M. P., Bruvera, I. J., Ibarra, M. R., Spasojević, V., Jančar, B.,& Antić, B.. (2012). Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy. in Journal of Materials Chemistry, 22(45), 24017-24025.
https://doi.org/10.1039/c2jm35593k

Radović M, Vranješ-Đurić S, Nikolić NS, Janković D, Goya GF, Torres TE, Calatayud MP, Bruvera IJ, Ibarra MR, Spasojević V, Jančar B, Antić B. Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy. in Journal of Materials Chemistry. 2012;22(45):24017-24025.
doi:10.1039/c2jm35593k .

Radović, Magdalena, Vranješ-Đurić, Sanja, Nikolić, Nadežda S., Janković, Drina, Goya, Gerardo F., Torres, Teobaldo E., Calatayud, Maria Pilar, Bruvera, Ignacio J., Ibarra, M. Ricardo, Spasojević, Vojislav, Jančar, Boštjan, Antić, Bratislav, "Development and evaluation of Y-90-labeled albumin microspheres loaded with magnetite nanoparticles for possible applications in cancer therapy" in Journal of Materials Chemistry, 22, no. 45 (2012):24017-24025,
https://doi.org/10.1039/c2jm35593k . .