TY  - JOUR
AU  - Karageorgou, Maria-Argyro
AU  - Rapsomanikis, Aristotelis-Nikolaos
AU  - Mirković, Marija D.
AU  - Vranješ-Đurić, Sanja
AU  - Stiliaris, Efstathios
AU  - Bouziotis, Penelope
AU  - Stamopoulos, Dimosthenis
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10405
AB  - The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis. For this reason, dual-modality contrast agents (DMCAs), such as radiolabeled iron oxide (namely Fe3O4) nanoparticles, constitute a powerful tool in diagnostic applications. In this respect, here we focus on the synthesis of a potential single photon emission computed tomography/magnetic resonance imaging (SPECT/MRI) DMCA, which consists of Fe3O4 nanoparticles, surface functionalized with 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD) and radiolabeled with 99mTc, [99mTc]Tc-DPD-Fe3O4. The in vitro stability results showed that this DMCA is highly stable after 24 h of incubation in phosphate buffer saline (~92.3% intact), while it is adequately stable after 24 h of incubation with human serum (~67.3% intact). Subsequently, [99mTc]Tc-DPD-Fe3O4 DMCA was evaluated in vivo in mice models through standard biodistribution studies, MR imaging and gamma-camera imaging. All techniques provided consistent results, clearly evidencing noticeable liver uptake. Our work documents that [99mTc]Tc-DPD-Fe3O4 has all the necessary characteristics to be a potential DMCA.
T2  - Nanomaterials
T1  - 99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models
VL  - 12
IS  - 15
SP  - 2728
DO  - 10.3390/nano12152728
ER  - 

@article{
author = "Karageorgou, Maria-Argyro and Rapsomanikis, Aristotelis-Nikolaos and Mirković, Marija D. and Vranješ-Đurić, Sanja and Stiliaris, Efstathios and Bouziotis, Penelope and Stamopoulos, Dimosthenis",
year = "2022",
abstract = "The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis. For this reason, dual-modality contrast agents (DMCAs), such as radiolabeled iron oxide (namely Fe3O4) nanoparticles, constitute a powerful tool in diagnostic applications. In this respect, here we focus on the synthesis of a potential single photon emission computed tomography/magnetic resonance imaging (SPECT/MRI) DMCA, which consists of Fe3O4 nanoparticles, surface functionalized with 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD) and radiolabeled with 99mTc, [99mTc]Tc-DPD-Fe3O4. The in vitro stability results showed that this DMCA is highly stable after 24 h of incubation in phosphate buffer saline (~92.3% intact), while it is adequately stable after 24 h of incubation with human serum (~67.3% intact). Subsequently, [99mTc]Tc-DPD-Fe3O4 DMCA was evaluated in vivo in mice models through standard biodistribution studies, MR imaging and gamma-camera imaging. All techniques provided consistent results, clearly evidencing noticeable liver uptake. Our work documents that [99mTc]Tc-DPD-Fe3O4 has all the necessary characteristics to be a potential DMCA.",
journal = "Nanomaterials",
title = "99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models",
volume = "12",
number = "15",
pages = "2728",
doi = "10.3390/nano12152728"
}

Karageorgou, M., Rapsomanikis, A., Mirković, M. D., Vranješ-Đurić, S., Stiliaris, E., Bouziotis, P.,& Stamopoulos, D.. (2022). 99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models. in Nanomaterials, 12(15), 2728.
https://doi.org/10.3390/nano12152728

Karageorgou M, Rapsomanikis A, Mirković MD, Vranješ-Đurić S, Stiliaris E, Bouziotis P, Stamopoulos D. 99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models. in Nanomaterials. 2022;12(15):2728.
doi:10.3390/nano12152728 .

Karageorgou, Maria-Argyro, Rapsomanikis, Aristotelis-Nikolaos, Mirković, Marija D., Vranješ-Đurić, Sanja, Stiliaris, Efstathios, Bouziotis, Penelope, Stamopoulos, Dimosthenis, "99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models" in Nanomaterials, 12, no. 15 (2022):2728,
https://doi.org/10.3390/nano12152728 . .