Pajović, Snežana B.

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Authority KeyName Variants
orcid::0000-0002-3524-2814
  • Pajović, Snežana B. (66)
Projects
Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications Acute coronary syndrome: investigation of vulnerability (plaque, blood and myocardium), optimal treatment and determination of the factors for the prognosis
Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals
Natural products of wild, cultivated and edible plants: structure and bioactivity determination Proučavanje poremećaja homeostaze i određivanje biomarkera oksidacionog stresa kod aerobnih organizama
Ministry of Science and Environmental Protection of the Republic of Serbia [143035 B, 143044 B] Ministry of Science and Technological Development of the Republic of Serbia [143044B]
Ministry of Science and Technology of the Republic of Serbia [143044B, 143035B] Ministry of Sciences of the Republic of Serbia [143044B]
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200178 (University of Belgrade, Faculty of Biology)
Biosensing Technologies and Global System for Long-Term Research and Integrated Management of Ecosystems Establishing typology of running waters in Serbia
Signalni putevi delovanja steroidnih hormona i uticaj endogenih i egzogenih faktora na modulaciju procesa u ćelijama sisara Ministry of Science and Technological Development of Republic of Serbia [143035B]
Ministry of Science and Technological Development, Republic of Serbia [143035 B, 143044 B] Ministry of Science, Technology, and Environmental Protection of the Republic of Serbia [143035 B, 143044 B]

Author's Bibliography

Antidepressants- and antipsychotics-induced hepatotoxicity

Todorović Vukotić, Nevena; Đorđević, Jelena; Pejić, Snežana; Đorđević, Neda O.; Pajović, Snežana B.

(2021)

TY  - JOUR
AU  - Todorović Vukotić, Nevena
AU  - Đorđević, Jelena
AU  - Pejić, Snežana
AU  - Đorđević, Neda O.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9078
AB  - Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
T2  - Archives of Toxicology
T1  - Antidepressants- and antipsychotics-induced hepatotoxicity
VL  - 95
IS  - 3
SP  - 767
EP  - 789
DO  - 10.1007/s00204-020-02963-4
ER  - 
@article{
author = "Todorović Vukotić, Nevena and Đorđević, Jelena and Pejić, Snežana and Đorđević, Neda O. and Pajović, Snežana B.",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9078",
abstract = "Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.",
journal = "Archives of Toxicology",
title = "Antidepressants- and antipsychotics-induced hepatotoxicity",
volume = "95",
number = "3",
pages = "767-789",
doi = "10.1007/s00204-020-02963-4"
}
Todorović Vukotić, N., Đorđević, J., Pejić, S., Đorđević, N. O.,& Pajović, S. B. (2021). Antidepressants- and antipsychotics-induced hepatotoxicity.
Archives of Toxicology, 95(3), 767-789.
https://doi.org/10.1007/s00204-020-02963-4
Todorović Vukotić N, Đorđević J, Pejić S, Đorđević NO, Pajović SB. Antidepressants- and antipsychotics-induced hepatotoxicity. Archives of Toxicology. 2021;95(3):767-789
Todorović Vukotić Nevena, Đorđević Jelena, Pejić Snežana, Đorđević Neda O., Pajović Snežana B., "Antidepressants- and antipsychotics-induced hepatotoxicity" Archives of Toxicology, 95, no. 3 (2021):767-789,
https://doi.org/10.1007/s00204-020-02963-4 .
1
1

The effect of antioxidant status on overall survival in renal cell carcinoma

Pavlović, Ivan; Pejić, Snežana; Radojević-Škodrić, Sanja; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša M.; Basta-Jovanović, Gordana; Džamić, Zoran; Pajović, Snežana B.

(2020)


                                            

                                            
Pavlović, I., Pejić, S., Radojević-Škodrić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Basta-Jovanović, G., Džamić, Z.,& Pajović, S. B. (2020). The effect of antioxidant status on overall survival in renal cell carcinoma.
Archives of Medical Science, 16(1), 94-101.
https://doi.org/10.5114/aoms.2019.86818
Pavlović I, Pejić S, Radojević-Škodrić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Basta-Jovanović G, Džamić Z, Pajović SB. The effect of antioxidant status on overall survival in renal cell carcinoma. Archives of Medical Science. 2020;16(1):94-101
Pavlović Ivan, Pejić Snežana, Radojević-Škodrić Sanja, Todorović Ana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Basta-Jovanović Gordana, Džamić Zoran, Pajović Snežana B., "The effect of antioxidant status on overall survival in renal cell carcinoma" Archives of Medical Science, 16, no. 1 (2020):94-101,
https://doi.org/10.5114/aoms.2019.86818 .
1
1
1
1

Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium

Popović, Nataša M.; Stojiljković, Vesna; Pejić, Snežana; Todorović, Ana; Pavlović, Ivan; Gavrilović, Ljubica; Pajović, Snežana B.

(2019)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.hindawi.com/journals/omcl/2019/8745376/
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8085
AB  - This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.
T2  - Oxidative Medicine and Cellular Longevity
T1  - Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium
VL  - 2019
SP  - 1
EP  - 11
DO  - 10.1155/2019/8745376
ER  - 
@article{
author = "Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Gavrilović, Ljubica and Pajović, Snežana B.",
year = "2019",
url = "https://www.hindawi.com/journals/omcl/2019/8745376/, http://vinar.vin.bg.ac.rs/handle/123456789/8085",
abstract = "This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium",
volume = "2019",
pages = "1-11",
doi = "10.1155/2019/8745376"
}
Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., Gavrilović, L.,& Pajović, S. B. (2019). Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium.
Oxidative Medicine and Cellular Longevity, 2019, 1-11.
https://doi.org/10.1155/2019/8745376
Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Gavrilović L, Pajović SB. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. Oxidative Medicine and Cellular Longevity. 2019;2019:1-11
Popović Nataša M., Stojiljković Vesna, Pejić Snežana, Todorović Ana, Pavlović Ivan, Gavrilović Ljubica, Pajović Snežana B., "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium" Oxidative Medicine and Cellular Longevity, 2019 (2019):1-11,
https://doi.org/10.1155/2019/8745376 .
4
2
3

Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma

Todorović, Ana; Pejić, Snežana; Gavrilović, Ljubica; Pavlović, Ivan; Stojiljković, Vesna; Popović, Nataša M.; Pajović, Snežana B.

(2019)

TY  - JOUR
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Gavrilović, Ljubica
AU  - Pavlović, Ivan
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.mdpi.com/2076-3921/8/4/97
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8403
AB  - We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.
T2  - Antioxidants
T1  - Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma
VL  - 8
IS  - 4
SP  - 97
DO  - 10.3390/antiox8040097
ER  - 
@article{
author = "Todorović, Ana and Pejić, Snežana and Gavrilović, Ljubica and Pavlović, Ivan and Stojiljković, Vesna and Popović, Nataša M. and Pajović, Snežana B.",
year = "2019",
url = "https://www.mdpi.com/2076-3921/8/4/97, http://vinar.vin.bg.ac.rs/handle/123456789/8403",
abstract = "We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.",
journal = "Antioxidants",
title = "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma",
volume = "8",
number = "4",
pages = "97",
doi = "10.3390/antiox8040097"
}
Todorović, A., Pejić, S., Gavrilović, L., Pavlović, I., Stojiljković, V., Popović, N. M.,& Pajović, S. B. (2019). Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma.
Antioxidants, 8(4), 97.
https://doi.org/10.3390/antiox8040097
Todorović A, Pejić S, Gavrilović L, Pavlović I, Stojiljković V, Popović NM, Pajović SB. Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma. Antioxidants. 2019;8(4):97
Todorović Ana, Pejić Snežana, Gavrilović Ljubica, Pavlović Ivan, Stojiljković Vesna, Popović Nataša M., Pajović Snežana B., "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma" Antioxidants, 8, no. 4 (2019):97,
https://doi.org/10.3390/antiox8040097 .
4
4
4

Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine

Đorđević, Neda O.; Todorović, Nevena; Novaković, Irena T.; Pezo, Lato; Pejin, Boris; Maraš, Vesna; Tešević, Vele V.; Pajović, Snežana B.

(2018)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Todorović, Nevena
AU  - Novaković, Irena T.
AU  - Pezo, Lato
AU  - Pejin, Boris
AU  - Maraš, Vesna
AU  - Tešević, Vele V.
AU  - Pajović, Snežana B.
PY  - 2018
UR  - http://www.mdpi.com/1420-3049/23/8/1971
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7858
AB  - Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H2O2–stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions. The same trend was observed for catechin and gallic acid, the most abundant phenolics in the examined wine samples. Finally, the findings of an Artificial Neural Network (ANN) model were in a good agreement (r2 = 0.978) with the experimental data. All tested samples exhibited a protective effect in H2O2–stressed yeast cells. Pre-treatment with examined wines increased survival in H2O2–stressed cells and shifted antioxidative defense towards GPx–mediated defense. Finally, sensitivity analysis of obtained ANN model highlights the complexity of the impact that variations in the concentrations of specific phenolic components have on the antioxidant defense system.
T2  - Molecules
T1  - Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine
VL  - 23
IS  - 8
SP  - 1971
DO  - 10.3390/molecules23081971
ER  - 
@article{
author = "Đorđević, Neda O. and Todorović, Nevena and Novaković, Irena T. and Pezo, Lato and Pejin, Boris and Maraš, Vesna and Tešević, Vele V. and Pajović, Snežana B.",
year = "2018",
url = "http://www.mdpi.com/1420-3049/23/8/1971, http://vinar.vin.bg.ac.rs/handle/123456789/7858",
abstract = "Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H2O2–stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions. The same trend was observed for catechin and gallic acid, the most abundant phenolics in the examined wine samples. Finally, the findings of an Artificial Neural Network (ANN) model were in a good agreement (r2 = 0.978) with the experimental data. All tested samples exhibited a protective effect in H2O2–stressed yeast cells. Pre-treatment with examined wines increased survival in H2O2–stressed cells and shifted antioxidative defense towards GPx–mediated defense. Finally, sensitivity analysis of obtained ANN model highlights the complexity of the impact that variations in the concentrations of specific phenolic components have on the antioxidant defense system.",
journal = "Molecules",
title = "Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine",
volume = "23",
number = "8",
pages = "1971",
doi = "10.3390/molecules23081971"
}
Đorđević, N. O., Todorović, N., Novaković, I. T., Pezo, L., Pejin, B., Maraš, V., Tešević, V. V.,& Pajović, S. B. (2018). Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine.
Molecules, 23(8), 1971.
https://doi.org/10.3390/molecules23081971
Đorđević NO, Todorović N, Novaković IT, Pezo L, Pejin B, Maraš V, Tešević VV, Pajović SB. Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine. Molecules. 2018;23(8):1971
Đorđević Neda O., Todorović Nevena, Novaković Irena T., Pezo Lato, Pejin Boris, Maraš Vesna, Tešević Vele V., Pajović Snežana B., "Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine" Molecules, 23, no. 8 (2018):1971,
https://doi.org/10.3390/molecules23081971 .
10
8
9

Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro

Đorđević, Neda O.; Pejin, Boris; Novaković, Miroslav M.; Stanković, Dalibor M.; Mutić, Jelena J.; Pajović, Snežana B.; Tešević, Vele V.

(2018)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor M.
AU  - Mutić, Jelena J.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1863
AB  - The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.
T2  - Natural Product Research
T1  - Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro
VL  - 32
IS  - 3
SP  - 247
EP  - 251
DO  - 10.1080/14786419.2017.1347171
ER  - 
@article{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor M. and Mutić, Jelena J. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1863",
abstract = "The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.",
journal = "Natural Product Research",
title = "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro",
volume = "32",
number = "3",
pages = "247-251",
doi = "10.1080/14786419.2017.1347171"
}
Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D. M., Mutić, J. J., Pajović, S. B.,& Tešević, V. V. (2018). Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro.
Natural Product Research, 32(3), 247-251.
https://doi.org/10.1080/14786419.2017.1347171
Đorđević NO, Pejin B, Novaković MM, Stanković DM, Mutić JJ, Pajović SB, Tešević VV. Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro. Natural Product Research. 2018;32(3):247-251
Đorđević Neda O., Pejin Boris, Novaković Miroslav M., Stanković Dalibor M., Mutić Jelena J., Pajović Snežana B., Tešević Vele V., "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro" Natural Product Research, 32, no. 3 (2018):247-251,
https://doi.org/10.1080/14786419.2017.1347171 .
6
6
6

Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Todorović, Ana; Pejić, Snežana; Pavlović, Ivan; Gavrilović, Ljubica

(2018)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8404
AB  - The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
T2  - Neurophysiology
T1  - Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats
VL  - 50
IS  - 5
SP  - 332
EP  - 338
DO  - 10.1007/s11062-019-09758-z
ER  - 
@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8404",
abstract = "The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "Neurophysiology",
title = "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats",
volume = "50",
number = "5",
pages = "332-338",
doi = "10.1007/s11062-019-09758-z"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L. (2018). Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats.
Neurophysiology, 50(5), 332-338.
https://doi.org/10.1007/s11062-019-09758-z
Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats. Neurophysiology. 2018;50(5):332-338
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Todorović Ana, Pejić Snežana, Pavlović Ivan, Gavrilović Ljubica, "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats" Neurophysiology, 50, no. 5 (2018):332-338,
https://doi.org/10.1007/s11062-019-09758-z .

Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System

Bartholomew, Ibeh; Gavrilović, Ljubica; Stojiljković, Vesna; Popović, Nataša M.; Pejić, Snežana; Todorović, Ana; Pavlović, Ivan; Pajović, Snežana B.

(IntechOpen, 2018)

TY  - CHAP
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8406
AB  - We examined the effects of daily exercise on the gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenyl
ethanolamine N-methyltransferase (PNMT)), vesicular monoamine transporter 2 (VMAT 2),
antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), concentrations of catecholamines (noradrenaline (NA) and adrenaline (A))
and malondialdehyde (MDA), activities of monoamine oxidase (MAO), and antioxidant
enzymes in the spleen of chronically psychosocially stressed rats. Exposure of chronically
stressed rats to exercise increased the levels of PNMT protein by 19%, VMAT 2 mRNA by
100%, NA by 160%, and A by 140%; decreased/unchanged MAO enzyme activity; returned
concentrations of MDA to control level; and increased CAT and GPx mRNA levels (50%
and 150%, respectively). Exercise induced the accumulation of the catecholamines and a
decrease of stress-induced oxidative stress in the spleen, which may significantly affect the
immune-neuroendocrine interactions in stress conditions. Also, exercise induced the catecholaminergic system and antioxidant defense to become more ready to a novel stressor,
which indicates that exercise may induce potentially positive physiological adaptations.
Our combined model of chronic social isolation and long-term daily treadmill running in
rats may be a good animal model in the research of therapeutic role of exercise in human
disease caused by chronic stress.
PB  - IntechOpen
PB  - InTech
T2  - Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh
T1  - Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System
IS  - Ch. 14
SP  - 283
EP  - 310
DO  - 10.5772/intechopen.70008
ER  - 
@article{
editor = "Bartholomew, Ibeh",
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Popović, Nataša M. and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pajović, Snežana B.",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8406",
abstract = "We examined the effects of daily exercise on the gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenyl
ethanolamine N-methyltransferase (PNMT)), vesicular monoamine transporter 2 (VMAT 2),
antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), concentrations of catecholamines (noradrenaline (NA) and adrenaline (A))
and malondialdehyde (MDA), activities of monoamine oxidase (MAO), and antioxidant
enzymes in the spleen of chronically psychosocially stressed rats. Exposure of chronically
stressed rats to exercise increased the levels of PNMT protein by 19%, VMAT 2 mRNA by
100%, NA by 160%, and A by 140%; decreased/unchanged MAO enzyme activity; returned
concentrations of MDA to control level; and increased CAT and GPx mRNA levels (50%
and 150%, respectively). Exercise induced the accumulation of the catecholamines and a
decrease of stress-induced oxidative stress in the spleen, which may significantly affect the
immune-neuroendocrine interactions in stress conditions. Also, exercise induced the catecholaminergic system and antioxidant defense to become more ready to a novel stressor,
which indicates that exercise may induce potentially positive physiological adaptations.
Our combined model of chronic social isolation and long-term daily treadmill running in
rats may be a good animal model in the research of therapeutic role of exercise in human
disease caused by chronic stress.",
publisher = "IntechOpen, InTech",
journal = "Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh",
title = "Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System",
number = "Ch. 14",
pages = "283-310",
doi = "10.5772/intechopen.70008"
}
Bartholomew, I., Gavrilović, L., Stojiljković, V., Popović, N. M., Pejić, S., Todorović, A., Pavlović, I.,& Pajović, S. B. (2018). Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System.
Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh
InTech.(Ch. 14), 283-310.
https://doi.org/10.5772/intechopen.70008
Bartholomew I, Gavrilović L, Stojiljković V, Popović NM, Pejić S, Todorović A, Pavlović I, Pajović SB. Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System. Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh. 2018;(Ch. 14):283-310
Bartholomew Ibeh, Gavrilović Ljubica, Stojiljković Vesna, Popović Nataša M., Pejić Snežana, Todorović Ana, Pavlović Ivan, Pajović Snežana B., "Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System" Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh, no. Ch. 14 (2018):283-310,
https://doi.org/10.5772/intechopen.70008 .
2

Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Pejić, Snežana; Todorović, Ana; Pavlović, Ivan; Gavrilović, Ljubica

(2017)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1588
AB  - This study examined the effects of chronic restraint stress (CRS) on gene expression of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), dopamine transporter (DAT), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2), catechol-O-methyltransferase (COMT) and antioxidant enzymes such as superoxide dismutase (SOD1 and SOD2), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), as well as concentrations of dopamine (DA) and noradrenaline (NA), activities of monoamine oxidase (MAO A and MAOB) and activities of antioxidant enzymes (SOD1, SOD2, CAT, GPx and GR) in the rat prefrontal cortex (PFC). We found that CRS decreases gene expression of TH and DBH and concentrations of DA, which probably confirms the decrease of de novo synthesis of catecholamine. CRS increased protein levels of NET and VMAT2, which was followed by increased NA concentration. The increased activity of MAO A and MAO B, as well as increased protein levels of COMT probably indicate increased catecholamine degradation, which was followed by increased activity of SOD1, SOD2 and CAT, as well as decreased activity of GPx under stress conditions. Our findings confirm the increased prefrontal noradrenergic turnover in animals exposed to CRS. The molecular mechanisms by which CRS changes catecholaminergic turnover and the antioxidant defense system in the PFC may be very important for research on numerous psychiatric diseases caused by chronic stress.
T2  - Folia Biologica, Krakow
T1  - Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats
VL  - 65
IS  - 1
SP  - 43
EP  - 54
DO  - 10.3409/fb65_1.43
ER  - 
@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1588",
abstract = "This study examined the effects of chronic restraint stress (CRS) on gene expression of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), dopamine transporter (DAT), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2), catechol-O-methyltransferase (COMT) and antioxidant enzymes such as superoxide dismutase (SOD1 and SOD2), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), as well as concentrations of dopamine (DA) and noradrenaline (NA), activities of monoamine oxidase (MAO A and MAOB) and activities of antioxidant enzymes (SOD1, SOD2, CAT, GPx and GR) in the rat prefrontal cortex (PFC). We found that CRS decreases gene expression of TH and DBH and concentrations of DA, which probably confirms the decrease of de novo synthesis of catecholamine. CRS increased protein levels of NET and VMAT2, which was followed by increased NA concentration. The increased activity of MAO A and MAO B, as well as increased protein levels of COMT probably indicate increased catecholamine degradation, which was followed by increased activity of SOD1, SOD2 and CAT, as well as decreased activity of GPx under stress conditions. Our findings confirm the increased prefrontal noradrenergic turnover in animals exposed to CRS. The molecular mechanisms by which CRS changes catecholaminergic turnover and the antioxidant defense system in the PFC may be very important for research on numerous psychiatric diseases caused by chronic stress.",
journal = "Folia Biologica, Krakow",
title = "Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats",
volume = "65",
number = "1",
pages = "43-54",
doi = "10.3409/fb65_1.43"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I.,& Gavrilović, L. (2017). Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats.
Folia Biologica, Krakow, 65(1), 43-54.
https://doi.org/10.3409/fb65_1.43
Popović NM, Pajović SB, Stojiljković V, Pejić S, Todorović A, Pavlović I, Gavrilović L. Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats. Folia Biologica, Krakow. 2017;65(1):43-54
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Pejić Snežana, Todorović Ana, Pavlović Ivan, Gavrilović Ljubica, "Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats" Folia Biologica, Krakow, 65, no. 1 (2017):43-54,
https://doi.org/10.3409/fb65_1.43 .
4
5
5

Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro

Đorđević, Neda O.; Pejin, Boris; Novaković, Miroslav M.; Stanković, Dalibor M.; Mutić, Jelena J.; Pajović, Snežana B.; Tešević, Vele V.

(2017)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor M.
AU  - Mutić, Jelena J.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1773
AB  - The overall aim was to compare the quality of two Montenegrin Merlot wines obtained from new vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011, due to preliminary screening of the potential of novel Merlot vine clones for the wine industry. The content of phenolic compounds was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). Elemental composition was analysed using inductively coupled plasma optical emission spectrometery (ICP-OES) and inductively coupled plasma mass spectrometery (ICP-MS)]. Additionaly, antioxidant capacity was assessed by cyclic voltammetry. Compared with the commercial one, both wine clones contained higher percent of major phenolic compounds (namely, gallic acid and catechin) with top values recorded for VCR1 both in 2010 (30.46 +/- 0.42 mg/1) and 2011 (28.12 +/- 0.29 mg/1). The same wines were enriched with epicatechin, resveratrol, myricetin and quercetin. Furthermore, VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, both new Montenegrin Merlot wines represent good candidates for the commercialised wines with an indication of geographical origin.
T2  - Scientia Horticulturae
T1  - Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro
VL  - 225
SP  - 505
EP  - 511
DO  - 10.1016/j.scienta.2017.07.045
ER  - 
@article{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor M. and Mutić, Jelena J. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1773",
abstract = "The overall aim was to compare the quality of two Montenegrin Merlot wines obtained from new vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011, due to preliminary screening of the potential of novel Merlot vine clones for the wine industry. The content of phenolic compounds was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). Elemental composition was analysed using inductively coupled plasma optical emission spectrometery (ICP-OES) and inductively coupled plasma mass spectrometery (ICP-MS)]. Additionaly, antioxidant capacity was assessed by cyclic voltammetry. Compared with the commercial one, both wine clones contained higher percent of major phenolic compounds (namely, gallic acid and catechin) with top values recorded for VCR1 both in 2010 (30.46 +/- 0.42 mg/1) and 2011 (28.12 +/- 0.29 mg/1). The same wines were enriched with epicatechin, resveratrol, myricetin and quercetin. Furthermore, VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, both new Montenegrin Merlot wines represent good candidates for the commercialised wines with an indication of geographical origin.",
journal = "Scientia Horticulturae",
title = "Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro",
volume = "225",
pages = "505-511",
doi = "10.1016/j.scienta.2017.07.045"
}
Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D. M., Mutić, J. J., Pajović, S. B.,& Tešević, V. V. (2017). Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro.
Scientia Horticulturae, 225, 505-511.
https://doi.org/10.1016/j.scienta.2017.07.045
Đorđević NO, Pejin B, Novaković MM, Stanković DM, Mutić JJ, Pajović SB, Tešević VV. Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro. Scientia Horticulturae. 2017;225:505-511
Đorđević Neda O., Pejin Boris, Novaković Miroslav M., Stanković Dalibor M., Mutić Jelena J., Pajović Snežana B., Tešević Vele V., "Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro" Scientia Horticulturae, 225 (2017):505-511,
https://doi.org/10.1016/j.scienta.2017.07.045 .
9
9
9

Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis

Pavlović, Ivan; Pejić, Snežana; Glumac, Sofija; Todorović, Ana; Stojiljković, Vesna; Popović, Nataša M.; Gavrilović, Ljubica; Pajović, Snežana B.; Radojevic-Skodric, Sanja; Dzamic, Zoran; Basta-Jovanović, Gordana

(2017)

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Pejić, Snežana
AU  - Glumac, Sofija
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Gavrilović, Ljubica
AU  - Pajović, Snežana B.
AU  - Radojevic-Skodric, Sanja
AU  - Dzamic, Zoran
AU  - Basta-Jovanović, Gordana
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1857
AB  - Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC.
T2  - Journal of BUON
T1  - Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis
VL  - 22
IS  - 6
SP  - 1434
EP  - 1440
ER  - 
@article{
author = "Pavlović, Ivan and Pejić, Snežana and Glumac, Sofija and Todorović, Ana and Stojiljković, Vesna and Popović, Nataša M. and Gavrilović, Ljubica and Pajović, Snežana B. and Radojevic-Skodric, Sanja and Dzamic, Zoran and Basta-Jovanović, Gordana",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1857",
abstract = "Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC.",
journal = "Journal of BUON",
title = "Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis",
volume = "22",
number = "6",
pages = "1434-1440"
}
Pavlović, I., Pejić, S., Glumac, S., Todorović, A., Stojiljković, V., Popović, N. M., Gavrilović, L., Pajović, S. B., Radojevic-Skodric, S., Dzamic, Z.,& Basta-Jovanović, G. (2017). Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis.
Journal of BUON, 22(6), 1434-1440.
Pavlović I, Pejić S, Glumac S, Todorović A, Stojiljković V, Popović NM, Gavrilović L, Pajović SB, Radojevic-Skodric S, Dzamic Z, Basta-Jovanović G. Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis. Journal of BUON. 2017;22(6):1434-1440
Pavlović Ivan, Pejić Snežana, Glumac Sofija, Todorović Ana, Stojiljković Vesna, Popović Nataša M., Gavrilović Ljubica, Pajović Snežana B., Radojevic-Skodric Sanja, Dzamic Zoran, Basta-Jovanović Gordana, "Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis" Journal of BUON, 22, no. 6 (2017):1434-1440
2
2

Comparative analytical study of the selected wine varieties grown in Montenegro

Đorđević, Neda O.; Novaković, Miroslav M.; Pejin, Boris; Mutić, Jelena J.; Vajs, Vlatka E.; Pajović, Snežana B.; Tešević, Vele V.

(2017)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Mutić, Jelena J.
AU  - Vajs, Vlatka E.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1628
AB  - Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .
T2  - Natural Product Research
T1  - Comparative analytical study of the selected wine varieties grown in Montenegro
VL  - 31
IS  - 15
SP  - 1825
EP  - 1830
DO  - 10.1080/14786419.2017.1289209
ER  - 
@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Mutić, Jelena J. and Vajs, Vlatka E. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1628",
abstract = "Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .",
journal = "Natural Product Research",
title = "Comparative analytical study of the selected wine varieties grown in Montenegro",
volume = "31",
number = "15",
pages = "1825-1830",
doi = "10.1080/14786419.2017.1289209"
}
Đorđević, N. O., Novaković, M. M., Pejin, B., Mutić, J. J., Vajs, V. E., Pajović, S. B.,& Tešević, V. V. (2017). Comparative analytical study of the selected wine varieties grown in Montenegro.
Natural Product Research, 31(15), 1825-1830.
https://doi.org/10.1080/14786419.2017.1289209
Đorđević NO, Novaković MM, Pejin B, Mutić JJ, Vajs VE, Pajović SB, Tešević VV. Comparative analytical study of the selected wine varieties grown in Montenegro. Natural Product Research. 2017;31(15):1825-1830
Đorđević Neda O., Novaković Miroslav M., Pejin Boris, Mutić Jelena J., Vajs Vlatka E., Pajović Snežana B., Tešević Vele V., "Comparative analytical study of the selected wine varieties grown in Montenegro" Natural Product Research, 31, no. 15 (2017):1825-1830,
https://doi.org/10.1080/14786419.2017.1289209 .
3
8
7
7

Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Todorović, Ana; Pejić, Snežana; Pavlović, Ivan; Gavrilović, Ljubica

(2017)

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1908
AB  - This study examined the effects of chronic restraint stress (CRS: 2 hours x 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantified by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our findings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.
T2  - Acta Veterinaria, Beograd
T1  - Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
VL  - 67
IS  - 4
SP  - 540
EP  - 550
DO  - 10.1515/acve-2017-0043
ER  - 
@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1908",
abstract = "This study examined the effects of chronic restraint stress (CRS: 2 hours x 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantified by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our findings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.",
journal = "Acta Veterinaria, Beograd",
title = "Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats",
volume = "67",
number = "4",
pages = "540-550",
doi = "10.1515/acve-2017-0043"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L. (2017). Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats.
Acta Veterinaria, Beograd, 67(4), 540-550.
https://doi.org/10.1515/acve-2017-0043
Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats. Acta Veterinaria, Beograd. 2017;67(4):540-550
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Todorović Ana, Pejić Snežana, Pavlović Ivan, Gavrilović Ljubica, "Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats" Acta Veterinaria, Beograd, 67, no. 4 (2017):540-550,
https://doi.org/10.1515/acve-2017-0043 .
3
3
4

Superoxide dismutase and lipid peroxidation in children affected by celiac disease

Stojiljković, Vesna; Gavrilović, Ljubica; Pejić, Snežana; Todorović, Ana; Popović, Nataša M.; Pavlović, Ivan; Pajović, Snežana B.

(RAD Association, 2017)

TY  - CONF
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2017
UR  - http://www.rad-proceedings.org/paper.php?id=152
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7995
AB  - Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.
PB  - RAD Association
C3  - RAD Conference Proceedings
T1  - Superoxide dismutase and lipid peroxidation in children affected by celiac disease
VL  - 2
SP  - 237
EP  - 242
DO  - 10.21175/RadProc.2017.49
ER  - 
@conference{
author = "Stojiljković, Vesna and Gavrilović, Ljubica and Pejić, Snežana and Todorović, Ana and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2017",
url = "http://www.rad-proceedings.org/paper.php?id=152, http://vinar.vin.bg.ac.rs/handle/123456789/7995",
abstract = "Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.",
publisher = "RAD Association",
journal = "RAD Conference Proceedings",
title = "Superoxide dismutase and lipid peroxidation in children affected by celiac disease",
volume = "2",
pages = "237-242",
doi = "10.21175/RadProc.2017.49"
}
Stojiljković, V., Gavrilović, L., Pejić, S., Todorović, A., Popović, N. M., Pavlović, I.,& Pajović, S. B. (2017). Superoxide dismutase and lipid peroxidation in children affected by celiac disease.
RAD Conference Proceedings
RAD Association., 2, 237-242.
https://doi.org/10.21175/RadProc.2017.49
Stojiljković V, Gavrilović L, Pejić S, Todorović A, Popović NM, Pavlović I, Pajović SB. Superoxide dismutase and lipid peroxidation in children affected by celiac disease. RAD Conference Proceedings. 2017;2:237-242
Stojiljković Vesna, Gavrilović Ljubica, Pejić Snežana, Todorović Ana, Popović Nataša M., Pavlović Ivan, Pajović Snežana B., "Superoxide dismutase and lipid peroxidation in children affected by celiac disease" RAD Conference Proceedings, 2 (2017):237-242,
https://doi.org/10.21175/RadProc.2017.49 .

Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats

Popović, Nataša M.; Pajović, Snežana B.; Stojiljković, Vesna; Todorović, Ana; Pejić, Snežana; Pavlović, Ivan; Gavrilović, Ljubica

(RAD Association, 2017)

TY  - CONF
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - http://www.rad-proceedings.org/paper.php?id=155
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7996
AB  - Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.
PB  - RAD Association
C3  - RAD Conference Proceedings
T1  - Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats
VL  - 2
SP  - 255
EP  - 259
DO  - 10.21175/RadProc.2017.52
ER  - 
@conference{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
url = "http://www.rad-proceedings.org/paper.php?id=155, http://vinar.vin.bg.ac.rs/handle/123456789/7996",
abstract = "Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.",
publisher = "RAD Association",
journal = "RAD Conference Proceedings",
title = "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats",
volume = "2",
pages = "255-259",
doi = "10.21175/RadProc.2017.52"
}
Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L. (2017). Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats.
RAD Conference Proceedings
RAD Association., 2, 255-259.
https://doi.org/10.21175/RadProc.2017.52
Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats. RAD Conference Proceedings. 2017;2:255-259
Popović Nataša M., Pajović Snežana B., Stojiljković Vesna, Todorović Ana, Pejić Snežana, Pavlović Ivan, Gavrilović Ljubica, "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats" RAD Conference Proceedings, 2 (2017):255-259,
https://doi.org/10.21175/RadProc.2017.52 .
3
3

Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma

Pavlović, Ivan; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša M.; Pajović, Snežana B.; Pejić, Snežana

(2016)

TY  - CONF
AU  - Pavlović, Ivan
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Pejić, Snežana
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7171
AB  - Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.
C3  - RAD Conference Proceedings
T1  - Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma
SP  - 153
EP  - 155
DO  - 10.21175/RadProc.2016.36
ER  - 
@conference{
author = "Pavlović, Ivan and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B. and Pejić, Snežana",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7171",
abstract = "Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.",
journal = "RAD Conference Proceedings",
title = "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma",
pages = "153-155",
doi = "10.21175/RadProc.2016.36"
}
Pavlović, I., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Pajović, S. B.,& Pejić, S. (2016). Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma.
RAD Conference Proceedings, 153-155.
https://doi.org/10.21175/RadProc.2016.36
Pavlović I, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB, Pejić S. Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma. RAD Conference Proceedings. 2016;:153-155
Pavlović Ivan, Todorović Ana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Pajović Snežana B., Pejić Snežana, "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma" RAD Conference Proceedings (2016):153-155,
https://doi.org/10.21175/RadProc.2016.36 .

Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress

Pejić, Snežana; Stojiljković, Vesna; Todorović, Ana; Gavrilović, Ljubica; Pavlović, Ivan; Popović, Nataša M.; Pajović, Snežana B.

(2016)

TY  - JOUR
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Gavrilović, Ljubica
AU  - Pavlović, Ivan
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1301
AB  - The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.
T2  - Folia Biologica, Krakow
T1  - Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress
VL  - 64
IS  - 3
SP  - 189
EP  - 195
DO  - 10.3409/fb64_3.189
ER  - 
@article{
author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Gavrilović, Ljubica and Pavlović, Ivan and Popović, Nataša M. and Pajović, Snežana B.",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1301",
abstract = "The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.",
journal = "Folia Biologica, Krakow",
title = "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress",
volume = "64",
number = "3",
pages = "189-195",
doi = "10.3409/fb64_3.189"
}
Pejić, S., Stojiljković, V., Todorović, A., Gavrilović, L., Pavlović, I., Popović, N. M.,& Pajović, S. B. (2016). Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress.
Folia Biologica, Krakow, 64(3), 189-195.
https://doi.org/10.3409/fb64_3.189
Pejić S, Stojiljković V, Todorović A, Gavrilović L, Pavlović I, Popović NM, Pajović SB. Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress. Folia Biologica, Krakow. 2016;64(3):189-195
Pejić Snežana, Stojiljković Vesna, Todorović Ana, Gavrilović Ljubica, Pavlović Ivan, Popović Nataša M., Pajović Snežana B., "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress" Folia Biologica, Krakow, 64, no. 3 (2016):189-195,
https://doi.org/10.3409/fb64_3.189 .
5
3
3

Antioxidant status and sex hormones in women with complex endometrial hyperplasia

Pejić, Snežana; Todorović, Ana; Stojiljković, Vesna; Pavlović, Ivan; Gavrilović, Ljubica; Popović, Nataša M.; Pajović, Snežana B.

(2016)

TY  - JOUR
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1455
AB  - Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase. A significant phase-related difference of glutathione peroxidase and glutathione reductase activity was recorded in the endometrium. Both enzymes had lower activity in luteal phase and postmenopause compared to the follicular phase. The linear regression analysis of individual hormonal variables against antioxidant parameters showed negative correlation between glutathione peroxidase activity and gonadotropin concentrations in the endometrium. The regression of hyperplastic to normal endometrium is the purpose of conservative treatment based on administration of progestogens or gonadotropin-releasing hormone analogues. Our findings indicate that gonadotropins influence the antioxidant enzymes activity in women with complex endometrial hyperplasia, which may affect disease development. Further studies are needed to clarify the molecular basis of hormone action on antioxidant system that may potentially initiate a development of treatments based onredox-dependentmechanism.
T2  - Cellular and Molecular Biology
T1  - Antioxidant status and sex hormones in women with complex endometrial hyperplasia
VL  - 62
IS  - 11
SP  - 51
EP  - 56
DO  - 10.14715/cmb/2016.62.11.9
ER  - 
@article{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pavlović, Ivan and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1455",
abstract = "Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase. A significant phase-related difference of glutathione peroxidase and glutathione reductase activity was recorded in the endometrium. Both enzymes had lower activity in luteal phase and postmenopause compared to the follicular phase. The linear regression analysis of individual hormonal variables against antioxidant parameters showed negative correlation between glutathione peroxidase activity and gonadotropin concentrations in the endometrium. The regression of hyperplastic to normal endometrium is the purpose of conservative treatment based on administration of progestogens or gonadotropin-releasing hormone analogues. Our findings indicate that gonadotropins influence the antioxidant enzymes activity in women with complex endometrial hyperplasia, which may affect disease development. Further studies are needed to clarify the molecular basis of hormone action on antioxidant system that may potentially initiate a development of treatments based onredox-dependentmechanism.",
journal = "Cellular and Molecular Biology",
title = "Antioxidant status and sex hormones in women with complex endometrial hyperplasia",
volume = "62",
number = "11",
pages = "51-56",
doi = "10.14715/cmb/2016.62.11.9"
}
Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. M.,& Pajović, S. B. (2016). Antioxidant status and sex hormones in women with complex endometrial hyperplasia.
Cellular and Molecular Biology, 62(11), 51-56.
https://doi.org/10.14715/cmb/2016.62.11.9
Pejić S, Todorović A, Stojiljković V, Pavlović I, Gavrilović L, Popović NM, Pajović SB. Antioxidant status and sex hormones in women with complex endometrial hyperplasia. Cellular and Molecular Biology. 2016;62(11):51-56
Pejić Snežana, Todorović Ana, Stojiljković Vesna, Pavlović Ivan, Gavrilović Ljubica, Popović Nataša M., Pajović Snežana B., "Antioxidant status and sex hormones in women with complex endometrial hyperplasia" Cellular and Molecular Biology, 62, no. 11 (2016):51-56,
https://doi.org/10.14715/cmb/2016.62.11.9 .
2
2

Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones

Pejić, Snežana; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša M.; Pavlović, Ivan; Pajović, Snežana B.

(2015)

TY  - CONF
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7131
AB  - Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal changes, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex.
C3  - RAD Conference Proceedings
T1  - Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones
SP  - 467
EP  - 470
ER  - 
@conference{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7131",
abstract = "Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal changes, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex.",
journal = "RAD Conference Proceedings",
title = "Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones",
pages = "467-470"
}
Pejić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Pavlović, I.,& Pajović, S. B. (2015). Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones.
RAD Conference Proceedings, 467-470.
Pejić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pavlović I, Pajović SB. Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones. RAD Conference Proceedings. 2015;:467-470
Pejić Snežana, Todorović Ana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Pavlović Ivan, Pajović Snežana B., "Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones" RAD Conference Proceedings (2015):467-470

Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors

Pejić, Snežana; Stojiljković, Vesna; Todorović, Ana; Gavrilović, Ljubica; Popović, Nataša M.; Pavlović, Ivan; Pajović, Snežana B.

(2015)

TY  - JOUR
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/498
AB  - Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxidant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses.
T2  - Folia Biologica
T1  - Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors
VL  - 61
IS  - 1
SP  - 26
EP  - 32
ER  - 
@article{
author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/498",
abstract = "Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxidant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses.",
journal = "Folia Biologica",
title = "Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors",
volume = "61",
number = "1",
pages = "26-32"
}
Pejić, S., Stojiljković, V., Todorović, A., Gavrilović, L., Popović, N. M., Pavlović, I.,& Pajović, S. B. (2015). Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors.
Folia Biologica, 61(1), 26-32.
Pejić S, Stojiljković V, Todorović A, Gavrilović L, Popović NM, Pavlović I, Pajović SB. Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors. Folia Biologica. 2015;61(1):26-32
Pejić Snežana, Stojiljković Vesna, Todorović Ana, Gavrilović Ljubica, Popović Nataša M., Pavlović Ivan, Pajović Snežana B., "Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors" Folia Biologica, 61, no. 1 (2015):26-32
4

Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity

Todorović, Ana; Pejić, Snežana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša M.; Pavlović, Ivan; Saicic, Zorica S.; Pajović, Snežana B.

(2015)

TY  - JOUR
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Saicic, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/815
AB  - Purpose Previously, we examined manganese superoxide dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT) activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The results indicated that lower MnSOD activity and inducibility found in hippocampus might explain higher radiosensitivity of this brain region. Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD, and CAT activities after dose of 5 Gy and to find out if differences in MnSOD activity are caused by changes in its expression. Heads of 4-day-old female rats were irradiated with gamma-rays, using Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and cortex tissues were prepared for enzyme activity measurements and Western blot analysis. One hour after exposure, gamma-rays significantly decreased MnSOD activity in both examined brain regions. Twenty-four hours later, MnSOD recovery showed dose and regional dependence. It was weaker at higher doses and in hippocampal region. MnSOD expression changed in the similar manner as MnSOD activity only at lower doses of gamma-rays. In both examined brain regions, gamma radiation significantly decreased CuZnSOD activity and did not change activity of CAT. Our results confirmed that MnSOD plays an important role in different regional radiosensitivity but also showed that depending on dose, radiation affects MnSOD level by utterly different mechanisms. Postradiation changes of CuZnSOD and CAT are not regionally specific and therefore, cannot account for the different radiosensitivity of the hippocampus and cortex.
T2  - Childs Nervous System
T1  - Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity
VL  - 31
IS  - 12
SP  - 2249
EP  - 2256
DO  - 10.1007/s00381-015-2807-2
ER  - 
@article{
author = "Todorović, Ana and Pejić, Snežana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Saicic, Zorica S. and Pajović, Snežana B.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/815",
abstract = "Purpose Previously, we examined manganese superoxide dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT) activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The results indicated that lower MnSOD activity and inducibility found in hippocampus might explain higher radiosensitivity of this brain region. Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD, and CAT activities after dose of 5 Gy and to find out if differences in MnSOD activity are caused by changes in its expression. Heads of 4-day-old female rats were irradiated with gamma-rays, using Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and cortex tissues were prepared for enzyme activity measurements and Western blot analysis. One hour after exposure, gamma-rays significantly decreased MnSOD activity in both examined brain regions. Twenty-four hours later, MnSOD recovery showed dose and regional dependence. It was weaker at higher doses and in hippocampal region. MnSOD expression changed in the similar manner as MnSOD activity only at lower doses of gamma-rays. In both examined brain regions, gamma radiation significantly decreased CuZnSOD activity and did not change activity of CAT. Our results confirmed that MnSOD plays an important role in different regional radiosensitivity but also showed that depending on dose, radiation affects MnSOD level by utterly different mechanisms. Postradiation changes of CuZnSOD and CAT are not regionally specific and therefore, cannot account for the different radiosensitivity of the hippocampus and cortex.",
journal = "Childs Nervous System",
title = "Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity",
volume = "31",
number = "12",
pages = "2249-2256",
doi = "10.1007/s00381-015-2807-2"
}
Todorović, A., Pejić, S., Stojiljković, V., Gavrilović, L., Popović, N. M., Pavlović, I., Saicic, Z. S.,& Pajović, S. B. (2015). Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity.
Childs Nervous System, 31(12), 2249-2256.
https://doi.org/10.1007/s00381-015-2807-2
Todorović A, Pejić S, Stojiljković V, Gavrilović L, Popović NM, Pavlović I, Saicic ZS, Pajović SB. Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity. Childs Nervous System. 2015;31(12):2249-2256
Todorović Ana, Pejić Snežana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Pavlović Ivan, Saicic Zorica S., Pajović Snežana B., "Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity" Childs Nervous System, 31, no. 12 (2015):2249-2256,
https://doi.org/10.1007/s00381-015-2807-2 .
3
2
1

Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia

Gowder, Sivakumar Joghi Thatha; Pejić, Snežana; Todorović, Ana; Stojiljković, Vesna; Pavlović, Ivan; Gavrilović, Ljubica; Popović, Nataša M.; Pajović, Snežana B.

(IntechOpen, 2015)

TY  - CHAP
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8408
AB  - Cancer of the reproductive tract is an important source of morbidity and mortality among women worldwide. Factors affecting endometrial cancer and endometrial hyperplasia are known to be similar. Endometrial hyperplasia is abnormal proliferation of the glands and the stroma resulting in architectural and cytological modifications. Due to hormonal changes, this condition is most common among women who are nearing the menopause or have reached the menopause. Antioxidant system has a role in preventing cancer initiation and promotion. Since the carcinogenesis occurs in several stages, it is likely that the antioxidant defense depends on the type of cell and tissue. The objective of this study was to investigate whether antioxidant enzymes activities and lipid hydroperoxides concentration in patients with endometrial hyperplasia are influenced by the changes in sex hormones level (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. The material we used consisted of blood and endometrial tissue specimens of women diagnosed with endometrial hyperplasia simplex. Patients were divided in groups depending on the phase of the menstrual cycle: follicular phase, luteal phase and postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxides level were compared among the phases to test the differences and a linear regression model was used to evaluate the associations between hormone levels and antioxidant/oxidant variables. In the blood of examined patients, we observed a phase-related changes of LOOH concentrations. Significant negative correlation between FSH concentration and GR activity (r= -0.42, p<0.05) and significant positive correlation between LH and LOOH concentrations (r= 0.038, p<0.05) was found. In hyperplasia simplex tissue we recorded significant phase-related changes of LOOH level as well as of AO enzyme activities. SOD and CAT had similar activity pattern, which was higher in luteal phase and in postmenopause, compared to follicular phase (p<0.05). GPx and GR activities did not show any statistical difference. Also, negative correlation between progesterone and GR activity (r=-0.036, p<0.05) was observed. Hormonal influence on AO system is of importance in gynecological diseases etiology since they may promote cell proliferation but are also used in conservative therapy, especially for hyperplasia simplex. However, the role of ROS production as a risk factor for endometrial hyperplasia still needs to be clarified as well as the role of AO status in response to gonadotropins and sex steroids.
PB  - IntechOpen
PB  - InTech
T2  - Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder
T1  - Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia
IS  - Ch. 9
SP  - 243
EP  - 279
DO  - 10.5772/60853
ER  - 
@article{
editor = "Gowder, Sivakumar Joghi Thatha",
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pavlović, Ivan and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8408",
abstract = "Cancer of the reproductive tract is an important source of morbidity and mortality among women worldwide. Factors affecting endometrial cancer and endometrial hyperplasia are known to be similar. Endometrial hyperplasia is abnormal proliferation of the glands and the stroma resulting in architectural and cytological modifications. Due to hormonal changes, this condition is most common among women who are nearing the menopause or have reached the menopause. Antioxidant system has a role in preventing cancer initiation and promotion. Since the carcinogenesis occurs in several stages, it is likely that the antioxidant defense depends on the type of cell and tissue. The objective of this study was to investigate whether antioxidant enzymes activities and lipid hydroperoxides concentration in patients with endometrial hyperplasia are influenced by the changes in sex hormones level (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. The material we used consisted of blood and endometrial tissue specimens of women diagnosed with endometrial hyperplasia simplex. Patients were divided in groups depending on the phase of the menstrual cycle: follicular phase, luteal phase and postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxides level were compared among the phases to test the differences and a linear regression model was used to evaluate the associations between hormone levels and antioxidant/oxidant variables. In the blood of examined patients, we observed a phase-related changes of LOOH concentrations. Significant negative correlation between FSH concentration and GR activity (r= -0.42, p<0.05) and significant positive correlation between LH and LOOH concentrations (r= 0.038, p<0.05) was found. In hyperplasia simplex tissue we recorded significant phase-related changes of LOOH level as well as of AO enzyme activities. SOD and CAT had similar activity pattern, which was higher in luteal phase and in postmenopause, compared to follicular phase (p<0.05). GPx and GR activities did not show any statistical difference. Also, negative correlation between progesterone and GR activity (r=-0.036, p<0.05) was observed. Hormonal influence on AO system is of importance in gynecological diseases etiology since they may promote cell proliferation but are also used in conservative therapy, especially for hyperplasia simplex. However, the role of ROS production as a risk factor for endometrial hyperplasia still needs to be clarified as well as the role of AO status in response to gonadotropins and sex steroids.",
publisher = "IntechOpen, InTech",
journal = "Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder",
title = "Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia",
number = "Ch. 9",
pages = "243-279",
doi = "10.5772/60853"
}
Gowder, S. J. T., Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. M.,& Pajović, S. B. (2015). Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia.
Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder
InTech.(Ch. 9), 243-279.
https://doi.org/10.5772/60853
Gowder SJT, Pejić S, Todorović A, Stojiljković V, Pavlović I, Gavrilović L, Popović NM, Pajović SB. Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia. Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder. 2015;(Ch. 9):243-279
Gowder Sivakumar Joghi Thatha, Pejić Snežana, Todorović Ana, Stojiljković Vesna, Pavlović Ivan, Gavrilović Ljubica, Popović Nataša M., Pajović Snežana B., "Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia" Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder, no. Ch. 9 (2015):243-279,
https://doi.org/10.5772/60853 .
4

Antioxidant status in women with uterine leiomyoma: relation with sex hormones

Pejić, Snežana; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša M.; Pajović, Snežana B.

(2015)

TY  - JOUR
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/751
AB  - Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydroperoxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology.
T2  - Anais de Academia Brasileira de Ciencias
T1  - Antioxidant status in women with uterine leiomyoma: relation with sex hormones
VL  - 87
IS  - 3
SP  - 1771
EP  - 1782
DO  - 10.1590/0001-3765201520130416
ER  - 
@article{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/751",
abstract = "Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients with leiomyoma are influenced by changes in sex hormones and gonadotropins (estradiol (E2), progesterone, FSH, and LH) during menstrual cycle and in postmenopause. The material consisted of blood and uterine tissue specimens. Hormone concentrations were determined and assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and lipid hydroperoxides concentration were performed. In blood of examined women, a significant difference in catalase, glutathione peroxidase and glutathione reductase activity was recorded among the phases. There was also a positive correlation between the estradiol/progesterone concentration and the catalase activity. Progesterone negatively correlated with lipid hydroperoxides level. In myoma tissue, we recorded a phase-related difference in lipid hydroperoxides level and activities of superoxide dismutase, glutathione peroxidase activities, and glutathione reductase. Negative correlation was observed between FSH and glutathione peroxidase. The results suggest that antioxidant status in patients with uterine leiomyoma is influenced by the changes in sex hormones during the menstrual cycle and in postmenopause, indicating a role of the observed relationship in the leiomyoma etiology.",
journal = "Anais de Academia Brasileira de Ciencias",
title = "Antioxidant status in women with uterine leiomyoma: relation with sex hormones",
volume = "87",
number = "3",
pages = "1771-1782",
doi = "10.1590/0001-3765201520130416"
}
Pejić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Pajović, S. B. (2015). Antioxidant status in women with uterine leiomyoma: relation with sex hormones.
Anais de Academia Brasileira de Ciencias, 87(3), 1771-1782.
https://doi.org/10.1590/0001-3765201520130416
Pejić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB. Antioxidant status in women with uterine leiomyoma: relation with sex hormones. Anais de Academia Brasileira de Ciencias. 2015;87(3):1771-1782
Pejić Snežana, Todorović Ana, Stojiljković Vesna, Gavrilović Ljubica, Popović Nataša M., Pajović Snežana B., "Antioxidant status in women with uterine leiomyoma: relation with sex hormones" Anais de Academia Brasileira de Ciencias, 87, no. 3 (2015):1771-1782,
https://doi.org/10.1590/0001-3765201520130416 .
5
3
3

Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress

Martinović, Jelena; Todorović, Nevena; Bošković, Maja; Pajović, Snežana B.; Demajo, Miroslav; Filipović, Dragana

(2014)

TY  - JOUR
AU  - Martinović, Jelena
AU  - Todorović, Nevena
AU  - Bošković, Maja
AU  - Pajović, Snežana B.
AU  - Demajo, Miroslav
AU  - Filipović, Dragana
PY  - 2014
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/6058
AB  - Chronic oxidative stress plays an important role in depression. The aim of present study was to examine the stress-induced changes in serum corticosterone (CORT) levels, cytosolic protein carbonyl groups, malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO) and total superoxide dismutase (SOD) activity in the prefrontal cortex versus hippocampus of male Wistar rats exposed to acute (2 h of immobilization or cold), chronic (21d of social isolation) stress, and their combination (chronic + acute stress). The subcellular distribution of nuclear factor-kappa B (NF-kappa B) and cytosolic cyclooxygenase 2 (COX-2) protein expressions were also examined. Depressive- and anxiety-like behaviors were assessed via the forced swim, sucrose preference, and marble burying tests in chronically isolated rats. Although both acute stressors resulted in elevated CORT, increased MDA in the prefrontal cortex and NF-kappa B activation accompanied by increased NO in the hippocampus were detected only following acute cold stress. Chronic isolation resulted in no change in CORT levels, but disabled appropriate response to novel acute stress and led to depressive- and anxiety-like behaviors. Increased oxidative/nitrosative stress markers, likely by NF-kappa B nuclear translocation and concomitant COX-2 upregulation, associated with decreased SOD activity and GSH levels, suggested the existence of oxidative stress in the prefrontal cortex. In contrast, hippocampus was less susceptible to oxidative damage showing only increase in protein carbonyl groups and depleted GSH. Taken together, the prefrontal cortex seems to be more sensitive to oxidative stress than the hippocampus following chronic isolation stress, which may be relevant for further research related to stress-induced depressive-like behavior.
T2  - Molecular and Cellular Biochemistry
T1  - Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress
VL  - 393
IS  - 1-2
SP  - 43
EP  - 57
DO  - 10.1007/s11010-014-2045-z
ER  - 
@article{
author = "Martinović, Jelena and Todorović, Nevena and Bošković, Maja and Pajović, Snežana B. and Demajo, Miroslav and Filipović, Dragana",
year = "2014",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/6058",
abstract = "Chronic oxidative stress plays an important role in depression. The aim of present study was to examine the stress-induced changes in serum corticosterone (CORT) levels, cytosolic protein carbonyl groups, malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO) and total superoxide dismutase (SOD) activity in the prefrontal cortex versus hippocampus of male Wistar rats exposed to acute (2 h of immobilization or cold), chronic (21d of social isolation) stress, and their combination (chronic + acute stress). The subcellular distribution of nuclear factor-kappa B (NF-kappa B) and cytosolic cyclooxygenase 2 (COX-2) protein expressions were also examined. Depressive- and anxiety-like behaviors were assessed via the forced swim, sucrose preference, and marble burying tests in chronically isolated rats. Although both acute stressors resulted in elevated CORT, increased MDA in the prefrontal cortex and NF-kappa B activation accompanied by increased NO in the hippocampus were detected only following acute cold stress. Chronic isolation resulted in no change in CORT levels, but disabled appropriate response to novel acute stress and led to depressive- and anxiety-like behaviors. Increased oxidative/nitrosative stress markers, likely by NF-kappa B nuclear translocation and concomitant COX-2 upregulation, associated with decreased SOD activity and GSH levels, suggested the existence of oxidative stress in the prefrontal cortex. In contrast, hippocampus was less susceptible to oxidative damage showing only increase in protein carbonyl groups and depleted GSH. Taken together, the prefrontal cortex seems to be more sensitive to oxidative stress than the hippocampus following chronic isolation stress, which may be relevant for further research related to stress-induced depressive-like behavior.",
journal = "Molecular and Cellular Biochemistry",
title = "Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress",
volume = "393",
number = "1-2",
pages = "43-57",
doi = "10.1007/s11010-014-2045-z"
}
Martinović, J., Todorović, N., Bošković, M., Pajović, S. B., Demajo, M.,& Filipović, D. (2014). Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress.
Molecular and Cellular Biochemistry, 393(1-2), 43-57.
https://doi.org/10.1007/s11010-014-2045-z
Martinović J, Todorović N, Bošković M, Pajović SB, Demajo M, Filipović D. Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress. Molecular and Cellular Biochemistry. 2014;393(1-2):43-57
Martinović Jelena, Todorović Nevena, Bošković Maja, Pajović Snežana B., Demajo Miroslav, Filipović Dragana, "Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress" Molecular and Cellular Biochemistry, 393, no. 1-2 (2014):43-57,
https://doi.org/10.1007/s11010-014-2045-z .
73
66
70

Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats

Gavrilović, Ljubica; Stojiljković, Vesna; Kasapović, Jelena; Pejić, Snežana; Todorović, Ana; Pajović, Snežana B.; Dronjak, Slađana

(2013)

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pajović, Snežana B.
AU  - Dronjak, Slađana
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5189
AB  - The aim of this study was to examine how acute immobilization stress affects the concentrations of catecholamines in the plasma and the expression of the splenic catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in chronically socially isolated rats. We found that acute immobilization increases the plasma catecholamine levels and splenic PNMT protein levels in chronically socially isolated rats. These results show that acute stress of chronically stressed animals activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 37%, both of which can modulate the immune function.
T2  - Archives of biological sciences
T1  - Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats
VL  - 65
IS  - 1
SP  - 183
EP  - 189
DO  - 10.2298/ABS1301183G
ER  - 
@article{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Pajović, Snežana B. and Dronjak, Slađana",
year = "2013",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/5189",
abstract = "The aim of this study was to examine how acute immobilization stress affects the concentrations of catecholamines in the plasma and the expression of the splenic catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in chronically socially isolated rats. We found that acute immobilization increases the plasma catecholamine levels and splenic PNMT protein levels in chronically socially isolated rats. These results show that acute stress of chronically stressed animals activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 37%, both of which can modulate the immune function.",
journal = "Archives of biological sciences",
title = "Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats",
volume = "65",
number = "1",
pages = "183-189",
doi = "10.2298/ABS1301183G"
}
Gavrilović, L., Stojiljković, V., Kasapović, J., Pejić, S., Todorović, A., Pajović, S. B.,& Dronjak, S. (2013). Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats.
Archives of biological sciences, 65(1), 183-189.
https://doi.org/10.2298/ABS1301183G
Gavrilović L, Stojiljković V, Kasapović J, Pejić S, Todorović A, Pajović SB, Dronjak S. Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats. Archives of biological sciences. 2013;65(1):183-189
Gavrilović Ljubica, Stojiljković Vesna, Kasapović Jelena, Pejić Snežana, Todorović Ana, Pajović Snežana B., Dronjak Slađana, "Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats" Archives of biological sciences, 65, no. 1 (2013):183-189,
https://doi.org/10.2298/ABS1301183G .
1
1