TY  - CONF
AU  - Čolović, Mirjana
AU  - Krstić, Danijela
AU  - Luce, M.
AU  - Cricenti, A.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12978
AB  - 12-tungstosilicic acid (SiW12) and decavanadate (V10) are polyoxometalate compounds (POMs) exhibiting biological activity. In vitro studies of the influence SiW12 and V10 on synaptic plasma membrane (SPM) acetylcholinesterase (AChE) and Na,K-ATPase, respectively, showed that these POMs inhibit the enzyme activities in submicromolar concentrations. As Na,K-ATPase and AChE are membrane associated enzymes, the inhibition of their activities can result from the membrane changes induced by the inhibitor binding. Thus, the effect of SiW12 and V10 on the membrane structure was investigated by using Atomic Force Microscopy (AFM) technique. The obtained results demonstrated that the calculated average roughness values for SiW12 and V10 treated SPM were significantly higher (about 6 and 1.5 times, respectively), compared to untreated SPM preparation. The obtained changes indicate that both investigated POMs bind to the plasma membranes, and consequently their approved strong inhibitory potencies toward the membrane bound enzymes might be assigned to the induced membrane modifications.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
T1  - Effect of polyoxometalates on synaptic plasma membrane structure
VL  - 1
SP  - 507
EP  - 510
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12978
ER  - 

@conference{
author = "Čolović, Mirjana and Krstić, Danijela and Luce, M. and Cricenti, A.",
year = "2018",
abstract = "12-tungstosilicic acid (SiW12) and decavanadate (V10) are polyoxometalate compounds (POMs) exhibiting biological activity. In vitro studies of the influence SiW12 and V10 on synaptic plasma membrane (SPM) acetylcholinesterase (AChE) and Na,K-ATPase, respectively, showed that these POMs inhibit the enzyme activities in submicromolar concentrations. As Na,K-ATPase and AChE are membrane associated enzymes, the inhibition of their activities can result from the membrane changes induced by the inhibitor binding. Thus, the effect of SiW12 and V10 on the membrane structure was investigated by using Atomic Force Microscopy (AFM) technique. The obtained results demonstrated that the calculated average roughness values for SiW12 and V10 treated SPM were significantly higher (about 6 and 1.5 times, respectively), compared to untreated SPM preparation. The obtained changes indicate that both investigated POMs bind to the plasma membranes, and consequently their approved strong inhibitory potencies toward the membrane bound enzymes might be assigned to the induced membrane modifications.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings",
title = "Effect of polyoxometalates on synaptic plasma membrane structure",
volume = "1",
pages = "507-510",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12978"
}

Čolović, M., Krstić, D., Luce, M.,& Cricenti, A.. (2018). Effect of polyoxometalates on synaptic plasma membrane structure. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 507-510.
https://hdl.handle.net/21.15107/rcub_vinar_12978

Čolović M, Krstić D, Luce M, Cricenti A. Effect of polyoxometalates on synaptic plasma membrane structure. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings. 2018;1:507-510.
https://hdl.handle.net/21.15107/rcub_vinar_12978 .

Čolović, Mirjana, Krstić, Danijela, Luce, M., Cricenti, A., "Effect of polyoxometalates on synaptic plasma membrane structure" in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings, 1 (2018):507-510,
https://hdl.handle.net/21.15107/rcub_vinar_12978 .