TY  - JOUR
AU  - Lukić, Nikola
AU  - Stanković, Aleksandra
AU  - Dinčić, Evica
AU  - Bundalo, Maja M.
AU  - Krsmanovic, Z.
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5506
AB  - The function of peroxisome proliferator-activated receptor gamma (PPAR gamma) in immune regulation, as well as in anti-inflammatory and anti-proliferative actions towards T lymphocytes, has been reported. A potential role of PPARs in multiple sclerosis (MS) was suggested. The aim of this study was to investigate if there is an association of PPAR gamma-2 Pro12Ala polymorphism with MS in 361 patients from Serbia. The genotype and allele frequencies of Pro12Ala polymorphism were not significantly different between controls and patients, or between females and males. In contrast to controls, we detected a rare Ala/Ala genotype in patients with MS. We found that there is a significant association of Ala/Ala genotype with older age at onset (ANOVA, p=0.07; LSD post-hoc, Ala/Ala vs. Pro/Ala, p=0.03, Ala/Ala vs. Pro/Pro p=0.02). It would be useful to validate our results in other populations, as well as to perform follow-up of the disease progression in regard to PPAR gamma genotypes.
T2  - Archives of Biological Sciences
T1  - The Ala/Ala Genotype of Pparγ Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis
VL  - 65
IS  - 2
SP  - 447
EP  - 453
DO  - 10.2298/ABS1302447L
ER  - 

@article{
author = "Lukić, Nikola and Stanković, Aleksandra and Dinčić, Evica and Bundalo, Maja M. and Krsmanovic, Z. and Alavantić, Dragan and Živković, Maja",
year = "2013",
abstract = "The function of peroxisome proliferator-activated receptor gamma (PPAR gamma) in immune regulation, as well as in anti-inflammatory and anti-proliferative actions towards T lymphocytes, has been reported. A potential role of PPARs in multiple sclerosis (MS) was suggested. The aim of this study was to investigate if there is an association of PPAR gamma-2 Pro12Ala polymorphism with MS in 361 patients from Serbia. The genotype and allele frequencies of Pro12Ala polymorphism were not significantly different between controls and patients, or between females and males. In contrast to controls, we detected a rare Ala/Ala genotype in patients with MS. We found that there is a significant association of Ala/Ala genotype with older age at onset (ANOVA, p=0.07; LSD post-hoc, Ala/Ala vs. Pro/Ala, p=0.03, Ala/Ala vs. Pro/Pro p=0.02). It would be useful to validate our results in other populations, as well as to perform follow-up of the disease progression in regard to PPAR gamma genotypes.",
journal = "Archives of Biological Sciences",
title = "The Ala/Ala Genotype of Pparγ Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis",
volume = "65",
number = "2",
pages = "447-453",
doi = "10.2298/ABS1302447L"
}

Lukić, N., Stanković, A., Dinčić, E., Bundalo, M. M., Krsmanovic, Z., Alavantić, D.,& Živković, M.. (2013). The Ala/Ala Genotype of Pparγ Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis. in Archives of Biological Sciences, 65(2), 447-453.
https://doi.org/10.2298/ABS1302447L

Lukić N, Stanković A, Dinčić E, Bundalo MM, Krsmanovic Z, Alavantić D, Živković M. The Ala/Ala Genotype of Pparγ Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis. in Archives of Biological Sciences. 2013;65(2):447-453.
doi:10.2298/ABS1302447L .

Lukić, Nikola, Stanković, Aleksandra, Dinčić, Evica, Bundalo, Maja M., Krsmanovic, Z., Alavantić, Dragan, Živković, Maja, "The Ala/Ala Genotype of Pparγ Pro12 Ala Polymorphism Is Associated with Late Onset of Multiple Sclerosis" in Archives of Biological Sciences, 65, no. 2 (2013):447-453,
https://doi.org/10.2298/ABS1302447L . .