TY  - CONF
AU  - Čudina, Olivera
AU  - Janković, Ivana A.
AU  - Brborić, Jasmina
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirov, Sote
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9370
AB  - The interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. To quantify the degree of VAL/CTAB interactions, two constants were calculated by using mathematical models: micelle/water partition coefficient and drug/micelle binding constant.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Study of valsartan interaction with micelles as a model system for biomembrane
VL  - 1
SP  - 366
EP  - 368
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9370
ER  - 

@conference{
author = "Čudina, Olivera and Janković, Ivana A. and Brborić, Jasmina and Karljiković-Rajić, Katarina and Vladimirov, Sote",
year = "2008",
abstract = "The interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. To quantify the degree of VAL/CTAB interactions, two constants were calculated by using mathematical models: micelle/water partition coefficient and drug/micelle binding constant.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Study of valsartan interaction with micelles as a model system for biomembrane",
volume = "1",
pages = "366-368",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9370"
}

Čudina, O., Janković, I. A., Brborić, J., Karljiković-Rajić, K.,& Vladimirov, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembrane. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 366-368.
https://hdl.handle.net/21.15107/rcub_vinar_9370

Čudina O, Janković IA, Brborić J, Karljiković-Rajić K, Vladimirov S. Study of valsartan interaction with micelles as a model system for biomembrane. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:366-368.
https://hdl.handle.net/21.15107/rcub_vinar_9370 .

Čudina, Olivera, Janković, Ivana A., Brborić, Jasmina, Karljiković-Rajić, Katarina, Vladimirov, Sote, "Study of valsartan interaction with micelles as a model system for biomembrane" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):366-368,
https://hdl.handle.net/21.15107/rcub_vinar_9370 .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Brborić, Jasmina
AU  - Janković, Ivana A.
AU  - Karljiković-Rajić, Katarina.
AU  - Vladimirova, S.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3494
AB  - In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC). (C) 2008 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. B: Biointerfaces
T1  - Study of valsartan interaction with micelles as a model system for biomembranes
VL  - 65
IS  - 1
SP  - 80
EP  - 84
DO  - 10.1016/j.colsurfb.2008.03.002
ER  - 

@article{
author = "Čudina, Olivera and Brborić, Jasmina and Janković, Ivana A. and Karljiković-Rajić, Katarina. and Vladimirova, S.",
year = "2008",
abstract = "In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC). (C) 2008 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. B: Biointerfaces",
title = "Study of valsartan interaction with micelles as a model system for biomembranes",
volume = "65",
number = "1",
pages = "80-84",
doi = "10.1016/j.colsurfb.2008.03.002"
}

Čudina, O., Brborić, J., Janković, I. A., Karljiković-Rajić, Katarina.,& Vladimirova, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces. B: Biointerfaces, 65(1), 80-84.
https://doi.org/10.1016/j.colsurfb.2008.03.002

Čudina O, Brborić J, Janković IA, Karljiković-Rajić K, Vladimirova S. Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces. B: Biointerfaces. 2008;65(1):80-84.
doi:10.1016/j.colsurfb.2008.03.002 .

Čudina, Olivera, Brborić, Jasmina, Janković, Ivana A., Karljiković-Rajić, Katarina., Vladimirova, S., "Study of valsartan interaction with micelles as a model system for biomembranes" in Colloids and Surfaces. B: Biointerfaces, 65, no. 1 (2008):80-84,
https://doi.org/10.1016/j.colsurfb.2008.03.002 . .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Karljiković-Rajić, Katarina
AU  - Ruvarac-Bugarčić, Ivanka A.
AU  - Janković, Ivana A.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2878
AB  - In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). (c) 2005 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. A: Physicochemical and Engineering Aspects
T1  - Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide
VL  - 256
IS  - 2-3
SP  - 225
EP  - 232
DO  - 10.1016/j.colsurfa.2005.01.023
ER  - 

@article{
author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarčić, Ivanka A. and Janković, Ivana A.",
year = "2005",
abstract = "In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). (c) 2005 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects",
title = "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide",
volume = "256",
number = "2-3",
pages = "225-232",
doi = "10.1016/j.colsurfa.2005.01.023"
}

Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarčić, I. A.,& Janković, I. A.. (2005). Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 256(2-3), 225-232.
https://doi.org/10.1016/j.colsurfa.2005.01.023

Čudina O, Karljiković-Rajić K, Ruvarac-Bugarčić IA, Janković IA. Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects. 2005;256(2-3):225-232.
doi:10.1016/j.colsurfa.2005.01.023 .

Čudina, Olivera, Karljiković-Rajić, Katarina, Ruvarac-Bugarčić, Ivanka A., Janković, Ivana A., "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide" in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 256, no. 2-3 (2005):225-232,
https://doi.org/10.1016/j.colsurfa.2005.01.023 . .

TY  - CONF
AU  - Čudina, Olivera
AU  - Karljiković-Rajić, Katarina
AU  - Ruvarac-Bugarčić, Ivanka A.
AU  - Janković, Ivana A.
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9604
AB  - The interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was studied as a model system for drug/membrane interactions. From the dependence of first order derivative amplitude 1 D250.1 on CTAB concentration, by using mathematical models based on the partition of the drug between micellar and aqueous pseudo-phase, CTAB/water partition coefficient Kp was calculated.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
T1  - Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water
VL  - 2
SP  - 853
EP  - 855
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9604
ER  - 

@conference{
author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarčić, Ivanka A. and Janković, Ivana A.",
year = "2004",
abstract = "The interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was studied as a model system for drug/membrane interactions. From the dependence of first order derivative amplitude 1 D250.1 on CTAB concentration, by using mathematical models based on the partition of the drug between micellar and aqueous pseudo-phase, CTAB/water partition coefficient Kp was calculated.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry",
title = "Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water",
volume = "2",
pages = "853-855",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9604"
}

Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarčić, I. A.,& Janković, I. A.. (2004). Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 2, 853-855.
https://hdl.handle.net/21.15107/rcub_vinar_9604

Čudina O, Karljiković-Rajić K, Ruvarac-Bugarčić IA, Janković IA. Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry. 2004;2:853-855.
https://hdl.handle.net/21.15107/rcub_vinar_9604 .

Čudina, Olivera, Karljiković-Rajić, Katarina, Ruvarac-Bugarčić, Ivanka A., Janković, Ivana A., "Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water" in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry, 2 (2004):853-855,
https://hdl.handle.net/21.15107/rcub_vinar_9604 .

TY  - JOUR
AU  - Nikolić, Nadežda S.
AU  - Veselinović, Dragan S.
AU  - Vladimirov, Sote
AU  - Karljiković-Rajić, Katarina
AU  - Lingeman, H
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2714
AB  - Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis, for reduction of intermediary reactant diiminebisoxime (DI) (4,8-diaza-3,6,6,9-tetramethylundecane-3,8-diene-2,10-dione bisoxime) concerned two reductants (NaBH4 and KBH4), two solvents (ethanol and 2-propanol), and three mole ratios of reactant/reductants (1:1, 1:1.5, and 1:2). The simultaneous analysis of diastereo-enantiomeric HM-PAO content, as well as the content of starting DI, in different reduction mixtures were pet-formed using chiral ligand-exchange chromatography (CLEC). The separation of the samples of investigated reduction mixtures, obtained in the second step of HM-PAO synthesis, has been accomplished by using an achiral sorbent (RP- 18) and a chiral mobile phase (CMP) containing copper(II) complex with N,N-ditnethyl-L-phenylalanine (L-DM-PhA) as initial complex for CLEC. With 12 different reduction conditions, the obtained ratios of diastereoisomers d,l-HM-PAO: mesa-HM-PAO varied from 69.2:30.8 to 15.9:84.1, in comparison to the reduction in routine synthesis of HM-PAO which gives an equal mixture of diastereoisomers. The ternary mixed complexes formation recorded spectrophotometrically on addition of HM-PAO or DI to the mobile phase with binary complex Cu(L-DM-PhA)(2), due to the evidence of bathochromic shift of 46 nm for lambda(max) with significant difference in absorptivity contributes to separation mechanism. (C) 2003 Elsevier B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity
VL  - 34
IS  - 2
SP  - 285
EP  - 293
DO  - 10.1016/S0731-7085(03)00551-X
ER  - 

@article{
author = "Nikolić, Nadežda S. and Veselinović, Dragan S. and Vladimirov, Sote and Karljiković-Rajić, Katarina and Lingeman, H",
year = "2004",
abstract = "Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis, for reduction of intermediary reactant diiminebisoxime (DI) (4,8-diaza-3,6,6,9-tetramethylundecane-3,8-diene-2,10-dione bisoxime) concerned two reductants (NaBH4 and KBH4), two solvents (ethanol and 2-propanol), and three mole ratios of reactant/reductants (1:1, 1:1.5, and 1:2). The simultaneous analysis of diastereo-enantiomeric HM-PAO content, as well as the content of starting DI, in different reduction mixtures were pet-formed using chiral ligand-exchange chromatography (CLEC). The separation of the samples of investigated reduction mixtures, obtained in the second step of HM-PAO synthesis, has been accomplished by using an achiral sorbent (RP- 18) and a chiral mobile phase (CMP) containing copper(II) complex with N,N-ditnethyl-L-phenylalanine (L-DM-PhA) as initial complex for CLEC. With 12 different reduction conditions, the obtained ratios of diastereoisomers d,l-HM-PAO: mesa-HM-PAO varied from 69.2:30.8 to 15.9:84.1, in comparison to the reduction in routine synthesis of HM-PAO which gives an equal mixture of diastereoisomers. The ternary mixed complexes formation recorded spectrophotometrically on addition of HM-PAO or DI to the mobile phase with binary complex Cu(L-DM-PhA)(2), due to the evidence of bathochromic shift of 46 nm for lambda(max) with significant difference in absorptivity contributes to separation mechanism. (C) 2003 Elsevier B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity",
volume = "34",
number = "2",
pages = "285-293",
doi = "10.1016/S0731-7085(03)00551-X"
}

Nikolić, N. S., Veselinović, D. S., Vladimirov, S., Karljiković-Rajić, K.,& Lingeman, H.. (2004). Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity. in Journal of Pharmaceutical and Biomedical Analysis, 34(2), 285-293.
https://doi.org/10.1016/S0731-7085(03)00551-X

Nikolić NS, Veselinović DS, Vladimirov S, Karljiković-Rajić K, Lingeman H. Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity. in Journal of Pharmaceutical and Biomedical Analysis. 2004;34(2):285-293.
doi:10.1016/S0731-7085(03)00551-X .

Nikolić, Nadežda S., Veselinović, Dragan S., Vladimirov, Sote, Karljiković-Rajić, Katarina, Lingeman, H, "Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity" in Journal of Pharmaceutical and Biomedical Analysis, 34, no. 2 (2004):285-293,
https://doi.org/10.1016/S0731-7085(03)00551-X . .

TY  - JOUR
AU  - Nikolić, Nadežda S.
AU  - Veselinović, Dragan S.
AU  - Vučina, Jurij L.
AU  - Lingeman, H
AU  - Karljiković-Rajić, Katarina
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2661
AB  - The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)(2) and formation of mixed ternary complex. The optimal mole ratio of Cu(II):l-DM-PhA is 1:4, the pH should be between 4.1 and 4.2 and up to 0.8 mM of triethylamine is added for column presaturation with the initial complex. The elution order has been defined using isolated l-HM-PAO via l-HM-PAO L(+)tartrate and tneso-HM-PAO obtained by repeated recrystallization from the isomeric mixture of HM-PAO. Complete resolution between all isomers (R-S from 2.14 to 3.91) and partial resolution for meso(EE)/l-HM-PAO (R-S = 0.83) has been obtained. This means that the proposed chiral ligand-exchange chromatography (CLEC) can be used for determination of the isomeric purity of HM-PAO. This as an alternative method for resolution measurements with chiral columns. (C) 2003 Elsevier B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime
VL  - 32
IS  - 6
SP  - 1159
EP  - 1166
DO  - 10.1016/S0731-7085(03)00230-9
ER  - 

@article{
author = "Nikolić, Nadežda S. and Veselinović, Dragan S. and Vučina, Jurij L. and Lingeman, H and Karljiković-Rajić, Katarina",
year = "2003",
abstract = "The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)(2) and formation of mixed ternary complex. The optimal mole ratio of Cu(II):l-DM-PhA is 1:4, the pH should be between 4.1 and 4.2 and up to 0.8 mM of triethylamine is added for column presaturation with the initial complex. The elution order has been defined using isolated l-HM-PAO via l-HM-PAO L(+)tartrate and tneso-HM-PAO obtained by repeated recrystallization from the isomeric mixture of HM-PAO. Complete resolution between all isomers (R-S from 2.14 to 3.91) and partial resolution for meso(EE)/l-HM-PAO (R-S = 0.83) has been obtained. This means that the proposed chiral ligand-exchange chromatography (CLEC) can be used for determination of the isomeric purity of HM-PAO. This as an alternative method for resolution measurements with chiral columns. (C) 2003 Elsevier B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime",
volume = "32",
number = "6",
pages = "1159-1166",
doi = "10.1016/S0731-7085(03)00230-9"
}

Nikolić, N. S., Veselinović, D. S., Vučina, J. L., Lingeman, H.,& Karljiković-Rajić, K.. (2003). Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime. in Journal of Pharmaceutical and Biomedical Analysis, 32(6), 1159-1166.
https://doi.org/10.1016/S0731-7085(03)00230-9

Nikolić NS, Veselinović DS, Vučina JL, Lingeman H, Karljiković-Rajić K. Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(6):1159-1166.
doi:10.1016/S0731-7085(03)00230-9 .

Nikolić, Nadežda S., Veselinović, Dragan S., Vučina, Jurij L., Lingeman, H, Karljiković-Rajić, Katarina, "Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 6 (2003):1159-1166,
https://doi.org/10.1016/S0731-7085(03)00230-9 . .

TY  - JOUR
AU  - Marinkovic, V
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Čomor, Jožef J.
AU  - Zivanov-Stakic, D
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2337
AB  - The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved.
T2  - Il Farmaco
T1  - UV derivative spectrophotometric study of the photochemical degradation of nisoldipine
VL  - 55
IS  - 2
SP  - 128
EP  - 133
DO  - 10.1016/S0014-827X(00)00004-5
ER  - 

@article{
author = "Marinkovic, V and Agbaba, Danica and Karljiković-Rajić, Katarina and Čomor, Jožef J. and Zivanov-Stakic, D",
year = "2000",
abstract = "The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved.",
journal = "Il Farmaco",
title = "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine",
volume = "55",
number = "2",
pages = "128-133",
doi = "10.1016/S0014-827X(00)00004-5"
}

Marinkovic, V., Agbaba, D., Karljiković-Rajić, K., Čomor, J. J.,& Zivanov-Stakic, D.. (2000). UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Il Farmaco, 55(2), 128-133.
https://doi.org/10.1016/S0014-827X(00)00004-5

Marinkovic V, Agbaba D, Karljiković-Rajić K, Čomor JJ, Zivanov-Stakic D. UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Il Farmaco. 2000;55(2):128-133.
doi:10.1016/S0014-827X(00)00004-5 .

Marinkovic, V, Agbaba, Danica, Karljiković-Rajić, Katarina, Čomor, Jožef J., Zivanov-Stakic, D, "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine" in Il Farmaco, 55, no. 2 (2000):128-133,
https://doi.org/10.1016/S0014-827X(00)00004-5 . .