TY  - JOUR
AU  - Salhi, Adil
AU  - Essack, Magbubah
AU  - Alam, Tanvir
AU  - Bajić, Vladan P.
AU  - Ma, Lina
AU  - Radovanovic, Aleksandar
AU  - Marchand, Benoit
AU  - Schmeier, Sebastian
AU  - Zhang, Zhang
AU  - Bajić, Vladimir B.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1675
AB  - Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA (www.cbrc.kaust.edu.sa/des_ncrna). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource.
T2  - RNA Biology
T1  - DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining
VL  - 14
IS  - 7
SP  - 963
EP  - 971
DO  - 10.1080/15476286.2017.1312243
ER  - 

@article{
author = "Salhi, Adil and Essack, Magbubah and Alam, Tanvir and Bajić, Vladan P. and Ma, Lina and Radovanovic, Aleksandar and Marchand, Benoit and Schmeier, Sebastian and Zhang, Zhang and Bajić, Vladimir B.",
year = "2017",
abstract = "Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA (www.cbrc.kaust.edu.sa/des_ncrna). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource.",
journal = "RNA Biology",
title = "DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining",
volume = "14",
number = "7",
pages = "963-971",
doi = "10.1080/15476286.2017.1312243"
}

Salhi, A., Essack, M., Alam, T., Bajić, V. P., Ma, L., Radovanovic, A., Marchand, B., Schmeier, S., Zhang, Z.,& Bajić, V. B.. (2017). DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. in RNA Biology, 14(7), 963-971.
https://doi.org/10.1080/15476286.2017.1312243

Salhi A, Essack M, Alam T, Bajić VP, Ma L, Radovanovic A, Marchand B, Schmeier S, Zhang Z, Bajić VB. DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. in RNA Biology. 2017;14(7):963-971.
doi:10.1080/15476286.2017.1312243 .

Salhi, Adil, Essack, Magbubah, Alam, Tanvir, Bajić, Vladan P., Ma, Lina, Radovanovic, Aleksandar, Marchand, Benoit, Schmeier, Sebastian, Zhang, Zhang, Bajić, Vladimir B., "DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining" in RNA Biology, 14, no. 7 (2017):963-971,
https://doi.org/10.1080/15476286.2017.1312243 . .