Incerti, Sebastien

Link to this page

Authority KeyName Variants
orcid::0000-0002-0619-2053
  • Incerti, Sebastien (9)
  • Incerti, S (1)
Projects
High Energy Physics with the CMS Detector Radiosensitivity of human genome
Australian Research Council [ARC DP170100967] CNRS PICS France - Serbia [8070]
CNPQ [306298/2018-0] CNPq [306775/2015-8]
CNRS PICS France - Greece [7340] CNRS PICS France - Greece [7340, 8235]
CNRS PICS France - Greece [8235] CNRS PICS, France-Serbia [8070]
ESA [4000112863/14/NL/HB] ESA [No. 4000126645/19/NL/BW]
European Space Agency[4000126645/19/NL/BW, 4000132935/21/NL/CRS] European Space Agency [AO7146-4000107387/12/NL/AK], INSERM PhysiCancer MICRONAUTE Project, CNRS/MSTD - Serbia cooperation, International Associated Laboratories France-Japan (TYL/FJPPL) and France-Korea (FKPPL), FAPESP Foundation, in Brazil [2011/51594-2]
FAPESP [2011/51594-2, 2015/21873-8, 2018/15316-7, 2020/08647-7] FAPESP foundation in Brazil [2011/51594-2]
FAPESP foundation in Brazil [2011/51594-2], European Space Agency through the BioRadII [4000107387/12/NL/AK] FAPESP foundation in Brazil [2015/21873-8]
Fondo Affari Internazionali (FAI) of the INFN-LNS France-Serbia bilateral project [CNRS PICS 8070]
HORIZIN2020 [654002 ENSAR2] IdEx Bordeaux University - France - International Doctorates program of the "France-Korea Particle Physics Laboratory" International Associated Laboratory (2017-2020)
IdEx Bordeaux University - France International Post-doctorates program of the "France-Japan Particle Physics Laboratory" International Associated Laboratory Italy-Serbia bilateral project [MAECI PGR 00794]
JSPS KAKENHI [No. JP20K16840] Ministry of Education, Science and Technological Development of Serbia
Ministry of Education, Science & Technological Development, Serbia RFBR [No. 7-29-01005-of-m]

Author's Bibliography

A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast

Shin, Wook-Geun; Sakata, Dousatsu; Lampe, Nathanael; Belov, Oleg; Tran, Ngoc Hoang; Petrović, Ivan M.; Ristić-Fira, Aleksandra; Đorđević, Miloš; Bernal, Mario A.; Bordage, Marie-Claude; Francis, Ziad; Kyriakou, Ioanna; Perrot, Yann; Sasaki, Takashi; Villagrasa, Carmen; Guatelli, Susanna; Breton, Vincent; Emfietzoglou, Dimitris; Incerti, Sebastien

(2021)

TY  - JOUR
AU  - Shin, Wook-Geun
AU  - Sakata, Dousatsu
AU  - Lampe, Nathanael
AU  - Belov, Oleg
AU  - Tran, Ngoc Hoang
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Đorđević, Miloš
AU  - Bernal, Mario A.
AU  - Bordage, Marie-Claude
AU  - Francis, Ziad
AU  - Kyriakou, Ioanna
AU  - Perrot, Yann
AU  - Sasaki, Takashi
AU  - Villagrasa, Carmen
AU  - Guatelli, Susanna
AU  - Breton, Vincent
AU  - Emfietzoglou, Dimitris
AU  - Incerti, Sebastien
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9961
AB  - Accurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. The resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application “molecularDNA”, an example for users of Geant4-DNA, will soon be distributed through Geant4.
T2  - Cancers
T2  - Cancers
T1  - A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast
VL  - 13
IS  - 19
SP  - 4940
DO  - 10.3390/cancers13194940
ER  - 
@article{
author = "Shin, Wook-Geun and Sakata, Dousatsu and Lampe, Nathanael and Belov, Oleg and Tran, Ngoc Hoang and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Đorđević, Miloš and Bernal, Mario A. and Bordage, Marie-Claude and Francis, Ziad and Kyriakou, Ioanna and Perrot, Yann and Sasaki, Takashi and Villagrasa, Carmen and Guatelli, Susanna and Breton, Vincent and Emfietzoglou, Dimitris and Incerti, Sebastien",
year = "2021",
abstract = "Accurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. The resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application “molecularDNA”, an example for users of Geant4-DNA, will soon be distributed through Geant4.",
journal = "Cancers, Cancers",
title = "A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast",
volume = "13",
number = "19",
pages = "4940",
doi = "10.3390/cancers13194940"
}
Shin, W., Sakata, D., Lampe, N., Belov, O., Tran, N. H., Petrović, I. M., Ristić-Fira, A., Đorđević, M., Bernal, M. A., Bordage, M., Francis, Z., Kyriakou, I., Perrot, Y., Sasaki, T., Villagrasa, C., Guatelli, S., Breton, V., Emfietzoglou, D.,& Incerti, S.. (2021). A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast. in Cancers, 13(19), 4940.
https://doi.org/10.3390/cancers13194940
Shin W, Sakata D, Lampe N, Belov O, Tran NH, Petrović IM, Ristić-Fira A, Đorđević M, Bernal MA, Bordage M, Francis Z, Kyriakou I, Perrot Y, Sasaki T, Villagrasa C, Guatelli S, Breton V, Emfietzoglou D, Incerti S. A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast. in Cancers. 2021;13(19):4940.
doi:10.3390/cancers13194940 .
Shin, Wook-Geun, Sakata, Dousatsu, Lampe, Nathanael, Belov, Oleg, Tran, Ngoc Hoang, Petrović, Ivan M., Ristić-Fira, Aleksandra, Đorđević, Miloš, Bernal, Mario A., Bordage, Marie-Claude, Francis, Ziad, Kyriakou, Ioanna, Perrot, Yann, Sasaki, Takashi, Villagrasa, Carmen, Guatelli, Susanna, Breton, Vincent, Emfietzoglou, Dimitris, Incerti, Sebastien, "A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast" in Cancers, 13, no. 19 (2021):4940,
https://doi.org/10.3390/cancers13194940 . .
3
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DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time

Keta, Otilija; Petković, Vladana; Cirrone, Pablo; Petringa, Giada; Cuttone, Giacomo; Sakata, Dousatsu; Shin, Wook-Geun; Incerti, Sebastien; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(2021)

TY  - JOUR
AU  - Keta, Otilija
AU  - Petković, Vladana
AU  - Cirrone, Pablo
AU  - Petringa, Giada
AU  - Cuttone, Giacomo
AU  - Sakata, Dousatsu
AU  - Shin, Wook-Geun
AU  - Incerti, Sebastien
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9875
AB  - Purpose The complex relationship between linear energy transfer (LET) and cellular response to radiation is not yet fully elucidated. To better characterize DNA damage after irradiations with therapeutic protons, we monitored formation and disappearance of DNA double-strand breaks (DNA DSB) as a function of LET and time. Comparisons with conventional γ-rays and high LET carbon ions were also performed.Materials and Methods In the present work, we performed immunofluorescence-based assay to determine the amount of DNA DSB induced by different LET values along the 62 MeV therapeutic proton Spread out Bragg peak (SOBP) in three cancer cell lines, i.e. HTB140 melanoma, MCF-7 breast adenocarcinoma and HTB177 non-small lung cancer cells. Time dependence of foci formation was followed as well. To determine irradiation positions, corresponding to the desired LET values, numerical simulations were carried out using Geant4 toolkit. We compared γ-H2AX foci persistence after irradiations with protons to that of γ-rays and carbon ions.Results With the rise of LET values along the therapeutic proton SOBP, the increase of γ-H2AX foci number is detected in the three cell lines up to the distal end of the SOBP, while there is a decrease on its distal fall-off part. With the prolonged incubation time, the number of foci gradually drops tending to attain the residual level. For the maximum number of DNA DSB, irradiation with protons attain higher level than that of γ-rays. Carbon ions produce more DNA DSB than protons but not substantially. The number of residual foci produced by γ-rays is significantly lower than that of protons and particularly carbon ions. Carbon ions do not produce considerably higher number of foci than protons, as it could be expected due to their physical properties.Conclusions In situ visualization of γ-H2AX foci reveal creation of more lesions in the three cell lines by clinically relevant proton SOBP than γ-rays. The lack of significant differences in the number of γ-H2AX foci between the proton and carbon ion-irradiated samples suggests an increased complexity of DNA lesions and slower repair kinetics after carbon ions compared to protons. For all three irradiation types, there is no major difference between the three cell lines shortly after irradiations, while later on, the formation of residual foci starts to express the inherent nature of tested cells, therefore increasing discrepancy between them.
T2  - International Journal of Radiation Biology
T1  - DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time
VL  - 97
IS  - 9
SP  - 1229
EP  - 1240
DO  - 10.1080/09553002.2021.1948140
ER  - 
@article{
author = "Keta, Otilija and Petković, Vladana and Cirrone, Pablo and Petringa, Giada and Cuttone, Giacomo and Sakata, Dousatsu and Shin, Wook-Geun and Incerti, Sebastien and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2021",
abstract = "Purpose The complex relationship between linear energy transfer (LET) and cellular response to radiation is not yet fully elucidated. To better characterize DNA damage after irradiations with therapeutic protons, we monitored formation and disappearance of DNA double-strand breaks (DNA DSB) as a function of LET and time. Comparisons with conventional γ-rays and high LET carbon ions were also performed.Materials and Methods In the present work, we performed immunofluorescence-based assay to determine the amount of DNA DSB induced by different LET values along the 62 MeV therapeutic proton Spread out Bragg peak (SOBP) in three cancer cell lines, i.e. HTB140 melanoma, MCF-7 breast adenocarcinoma and HTB177 non-small lung cancer cells. Time dependence of foci formation was followed as well. To determine irradiation positions, corresponding to the desired LET values, numerical simulations were carried out using Geant4 toolkit. We compared γ-H2AX foci persistence after irradiations with protons to that of γ-rays and carbon ions.Results With the rise of LET values along the therapeutic proton SOBP, the increase of γ-H2AX foci number is detected in the three cell lines up to the distal end of the SOBP, while there is a decrease on its distal fall-off part. With the prolonged incubation time, the number of foci gradually drops tending to attain the residual level. For the maximum number of DNA DSB, irradiation with protons attain higher level than that of γ-rays. Carbon ions produce more DNA DSB than protons but not substantially. The number of residual foci produced by γ-rays is significantly lower than that of protons and particularly carbon ions. Carbon ions do not produce considerably higher number of foci than protons, as it could be expected due to their physical properties.Conclusions In situ visualization of γ-H2AX foci reveal creation of more lesions in the three cell lines by clinically relevant proton SOBP than γ-rays. The lack of significant differences in the number of γ-H2AX foci between the proton and carbon ion-irradiated samples suggests an increased complexity of DNA lesions and slower repair kinetics after carbon ions compared to protons. For all three irradiation types, there is no major difference between the three cell lines shortly after irradiations, while later on, the formation of residual foci starts to express the inherent nature of tested cells, therefore increasing discrepancy between them.",
journal = "International Journal of Radiation Biology",
title = "DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time",
volume = "97",
number = "9",
pages = "1229-1240",
doi = "10.1080/09553002.2021.1948140"
}
Keta, O., Petković, V., Cirrone, P., Petringa, G., Cuttone, G., Sakata, D., Shin, W., Incerti, S., Petrović, I. M.,& Ristić-Fira, A.. (2021). DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time. in International Journal of Radiation Biology, 97(9), 1229-1240.
https://doi.org/10.1080/09553002.2021.1948140
Keta O, Petković V, Cirrone P, Petringa G, Cuttone G, Sakata D, Shin W, Incerti S, Petrović IM, Ristić-Fira A. DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time. in International Journal of Radiation Biology. 2021;97(9):1229-1240.
doi:10.1080/09553002.2021.1948140 .
Keta, Otilija, Petković, Vladana, Cirrone, Pablo, Petringa, Giada, Cuttone, Giacomo, Sakata, Dousatsu, Shin, Wook-Geun, Incerti, Sebastien, Petrović, Ivan M., Ristić-Fira, Aleksandra, "DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time" in International Journal of Radiation Biology, 97, no. 9 (2021):1229-1240,
https://doi.org/10.1080/09553002.2021.1948140 . .
4
3
1
2

Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA

Sakata, Dousatsu; Belov, Oleg; Bordage, Marie-Claude; Emfietzoglou, Dimitris; Guatelli, Susanna; Inaniwa, Taku; Ivanchenko, Vladimir; Karamitros, Mathieu; Kyriakou, Ioanna; Lampe, Nathanael; Petrović, Ivan M.; Ristić-Fira, Aleksandra; Shin, Wook-Geun; Incerti, Sebastien

(2020)

TY  - JOUR
AU  - Sakata, Dousatsu
AU  - Belov, Oleg
AU  - Bordage, Marie-Claude
AU  - Emfietzoglou, Dimitris
AU  - Guatelli, Susanna
AU  - Inaniwa, Taku
AU  - Ivanchenko, Vladimir
AU  - Karamitros, Mathieu
AU  - Kyriakou, Ioanna
AU  - Lampe, Nathanael
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Shin, Wook-Geun
AU  - Incerti, Sebastien
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9751
AB  - Ionising radiation induced DNA damage and subsequent biological responses to it depend on the radiation's track-structure and its energy loss distribution pattern. To investigate the underlying biological mechanisms involved in such complex system, there is need of predicting biological response by integrated Monte Carlo (MC) simulations across physics, chemistry and biology. Hence, in this work, we have developed an application using the open source Geant4-DNA toolkit to propose a realistic "fully integrated" MC simulation to calculate both early DNA damage and subsequent biological responses with time. We had previously developed an application allowing simulations of radiation induced early DNA damage on a naked cell nucleus model. In the new version presented in this work, we have developed three additional important features: (1) modeling of a realistic cell geometry, (2) inclusion of a biological repair model, (3) refinement of DNA damage parameters for direct damage and indirect damage scoring. The simulation results are validated with experimental data in terms of Single Strand Break (SSB) yields for plasmid and Double Strand Break (DSB) yields for plasmid/human cell. In addition, the yields of indirect DSBs are compatible with the experimental scavengeable damage fraction. The simulation application also demonstrates agreement with experimental data of gamma -H2AX yields for gamma ray irradiation. Using this application, it is now possible to predict biological response along time through track-structure MC simulations.
T2  - Scientific Reports
T1  - Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA
VL  - 10
IS  - 1
SP  - 20788
DO  - 10.1038/s41598-020-75982-x
ER  - 
@article{
author = "Sakata, Dousatsu and Belov, Oleg and Bordage, Marie-Claude and Emfietzoglou, Dimitris and Guatelli, Susanna and Inaniwa, Taku and Ivanchenko, Vladimir and Karamitros, Mathieu and Kyriakou, Ioanna and Lampe, Nathanael and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Shin, Wook-Geun and Incerti, Sebastien",
year = "2020",
abstract = "Ionising radiation induced DNA damage and subsequent biological responses to it depend on the radiation's track-structure and its energy loss distribution pattern. To investigate the underlying biological mechanisms involved in such complex system, there is need of predicting biological response by integrated Monte Carlo (MC) simulations across physics, chemistry and biology. Hence, in this work, we have developed an application using the open source Geant4-DNA toolkit to propose a realistic "fully integrated" MC simulation to calculate both early DNA damage and subsequent biological responses with time. We had previously developed an application allowing simulations of radiation induced early DNA damage on a naked cell nucleus model. In the new version presented in this work, we have developed three additional important features: (1) modeling of a realistic cell geometry, (2) inclusion of a biological repair model, (3) refinement of DNA damage parameters for direct damage and indirect damage scoring. The simulation results are validated with experimental data in terms of Single Strand Break (SSB) yields for plasmid and Double Strand Break (DSB) yields for plasmid/human cell. In addition, the yields of indirect DSBs are compatible with the experimental scavengeable damage fraction. The simulation application also demonstrates agreement with experimental data of gamma -H2AX yields for gamma ray irradiation. Using this application, it is now possible to predict biological response along time through track-structure MC simulations.",
journal = "Scientific Reports",
title = "Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA",
volume = "10",
number = "1",
pages = "20788",
doi = "10.1038/s41598-020-75982-x"
}
Sakata, D., Belov, O., Bordage, M., Emfietzoglou, D., Guatelli, S., Inaniwa, T., Ivanchenko, V., Karamitros, M., Kyriakou, I., Lampe, N., Petrović, I. M., Ristić-Fira, A., Shin, W.,& Incerti, S.. (2020). Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA. in Scientific Reports, 10(1), 20788.
https://doi.org/10.1038/s41598-020-75982-x
Sakata D, Belov O, Bordage M, Emfietzoglou D, Guatelli S, Inaniwa T, Ivanchenko V, Karamitros M, Kyriakou I, Lampe N, Petrović IM, Ristić-Fira A, Shin W, Incerti S. Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA. in Scientific Reports. 2020;10(1):20788.
doi:10.1038/s41598-020-75982-x .
Sakata, Dousatsu, Belov, Oleg, Bordage, Marie-Claude, Emfietzoglou, Dimitris, Guatelli, Susanna, Inaniwa, Taku, Ivanchenko, Vladimir, Karamitros, Mathieu, Kyriakou, Ioanna, Lampe, Nathanael, Petrović, Ivan M., Ristić-Fira, Aleksandra, Shin, Wook-Geun, Incerti, Sebastien, "Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA" in Scientific Reports, 10, no. 1 (2020):20788,
https://doi.org/10.1038/s41598-020-75982-x . .
2
24
17
17

Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers

Petković, Vladana; Keta, Otilija D.; Vidosavljević, Marija Z.; Incerti, Sebastien; Ristić-Fira, Aleksandra; Petrović, Ivan M.

(2019)

TY  - JOUR
AU  - Petković, Vladana
AU  - Keta, Otilija D.
AU  - Vidosavljević, Marija Z.
AU  - Incerti, Sebastien
AU  - Ristić-Fira, Aleksandra
AU  - Petrović, Ivan M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8414
AB  - Purpose: Investigation of effects on DNA of γ-irradiated human cancer cells pretreated with free radical scavengers is aimed to create reference data which would enable assessment of the relative efficiency of high linear energy transfer (LET) radiations used in hadron therapy, i.e. protons and carbon ions. Materials and methods: MCF-7 breast and HTB177 lung cancer cells are irradiated with γ-rays. To minimize indirect effects of irradiation, dimethyl sulfoxide (DMSO) or glycerol are applied as free radical scavengers. Biological response to irradiation is evaluated through clonogenic cell survival, immunocytochemical and cell cycle analysis, as well as expression of proteins involved in DNA damage response. Results: Examined cell lines reveal similar level of radioresistance. Application of scavengers leads to the rise of cell survival and decreases the number of DNA double strand breaks in irradiated cells. Differences in cell cycle and protein expression between the two cell lines are probably caused by different DNA damage repair mechanisms that are activated. Conclusion: The obtained results show that DMSO and glycerol have good scavenging capacity, and may be used to minimize DNA damage induced by free radicals. Therefore, they will be used as the reference for comparison with high LET irradiations, as well as good experimental data suitable for validation of numerical simulations. © 2019, © 2019 Taylor & Francis Group, LLC.
T2  - International Journal of Radiation Biology
T1  - Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers
VL  - 95
IS  - 3
SP  - 274
EP  - 285
DO  - 10.1080/09553002.2019.1549753
ER  - 
@article{
author = "Petković, Vladana and Keta, Otilija D. and Vidosavljević, Marija Z. and Incerti, Sebastien and Ristić-Fira, Aleksandra and Petrović, Ivan M.",
year = "2019",
abstract = "Purpose: Investigation of effects on DNA of γ-irradiated human cancer cells pretreated with free radical scavengers is aimed to create reference data which would enable assessment of the relative efficiency of high linear energy transfer (LET) radiations used in hadron therapy, i.e. protons and carbon ions. Materials and methods: MCF-7 breast and HTB177 lung cancer cells are irradiated with γ-rays. To minimize indirect effects of irradiation, dimethyl sulfoxide (DMSO) or glycerol are applied as free radical scavengers. Biological response to irradiation is evaluated through clonogenic cell survival, immunocytochemical and cell cycle analysis, as well as expression of proteins involved in DNA damage response. Results: Examined cell lines reveal similar level of radioresistance. Application of scavengers leads to the rise of cell survival and decreases the number of DNA double strand breaks in irradiated cells. Differences in cell cycle and protein expression between the two cell lines are probably caused by different DNA damage repair mechanisms that are activated. Conclusion: The obtained results show that DMSO and glycerol have good scavenging capacity, and may be used to minimize DNA damage induced by free radicals. Therefore, they will be used as the reference for comparison with high LET irradiations, as well as good experimental data suitable for validation of numerical simulations. © 2019, © 2019 Taylor & Francis Group, LLC.",
journal = "International Journal of Radiation Biology",
title = "Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers",
volume = "95",
number = "3",
pages = "274-285",
doi = "10.1080/09553002.2019.1549753"
}
Petković, V., Keta, O. D., Vidosavljević, M. Z., Incerti, S., Ristić-Fira, A.,& Petrović, I. M.. (2019). Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers. in International Journal of Radiation Biology, 95(3), 274-285.
https://doi.org/10.1080/09553002.2019.1549753
Petković V, Keta OD, Vidosavljević MZ, Incerti S, Ristić-Fira A, Petrović IM. Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers. in International Journal of Radiation Biology. 2019;95(3):274-285.
doi:10.1080/09553002.2019.1549753 .
Petković, Vladana, Keta, Otilija D., Vidosavljević, Marija Z., Incerti, Sebastien, Ristić-Fira, Aleksandra, Petrović, Ivan M., "Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers" in International Journal of Radiation Biology, 95, no. 3 (2019):274-285,
https://doi.org/10.1080/09553002.2019.1549753 . .
9
6
6

Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

Sakata, Dousatsu; Lampe, Nathanael; Karamitros, Mathieu; Kyriakou, Ioanna; Belov, Oleg; Bernal, Mario A; Bolst, David; Bordage, Marie-Claude; Breton, Vincent; Brown, Jeremy M.C.; Francis, Ziad; Ivanchenko, Vladimir; Meylan, Sylvain; Murakami, Koichi; Okada, Shogo; Petrović, Ivan M.; Ristić-Fira, Aleksandra; Santin, Giovanni; Sarramia, David; Sasaki, Takashi; Shin, Wook-Geun; Tang, Nicolas; Tran, Hoang N; Villagrasa, Carmen; Emfietzoglou, Dimitris; Nieminen, Petteri; Guatelli, Susanna; Incerti, Sebastien

(2019)

TY  - JOUR
AU  - Sakata, Dousatsu
AU  - Lampe, Nathanael
AU  - Karamitros, Mathieu
AU  - Kyriakou, Ioanna
AU  - Belov, Oleg
AU  - Bernal, Mario A
AU  - Bolst, David
AU  - Bordage, Marie-Claude
AU  - Breton, Vincent
AU  - Brown, Jeremy M.C.
AU  - Francis, Ziad
AU  - Ivanchenko, Vladimir
AU  - Meylan, Sylvain
AU  - Murakami, Koichi
AU  - Okada, Shogo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Santin, Giovanni
AU  - Sarramia, David
AU  - Sasaki, Takashi
AU  - Shin, Wook-Geun
AU  - Tang, Nicolas
AU  - Tran, Hoang N
AU  - Villagrasa, Carmen
AU  - Emfietzoglou, Dimitris
AU  - Nieminen, Petteri
AU  - Guatelli, Susanna
AU  - Incerti, Sebastien
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S1120179719300882
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8206
AB  - The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC)simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs)and double strand breaks (DSBs)in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. © 2019 Associazione Italiana di Fisica Medica
T2  - Physica Medica
T1  - Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA
VL  - 62
SP  - 152
EP  - 157
DO  - 10.1016/j.ejmp.2019.04.010
ER  - 
@article{
author = "Sakata, Dousatsu and Lampe, Nathanael and Karamitros, Mathieu and Kyriakou, Ioanna and Belov, Oleg and Bernal, Mario A and Bolst, David and Bordage, Marie-Claude and Breton, Vincent and Brown, Jeremy M.C. and Francis, Ziad and Ivanchenko, Vladimir and Meylan, Sylvain and Murakami, Koichi and Okada, Shogo and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Santin, Giovanni and Sarramia, David and Sasaki, Takashi and Shin, Wook-Geun and Tang, Nicolas and Tran, Hoang N and Villagrasa, Carmen and Emfietzoglou, Dimitris and Nieminen, Petteri and Guatelli, Susanna and Incerti, Sebastien",
year = "2019",
abstract = "The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC)simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs)and double strand breaks (DSBs)in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. © 2019 Associazione Italiana di Fisica Medica",
journal = "Physica Medica",
title = "Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA",
volume = "62",
pages = "152-157",
doi = "10.1016/j.ejmp.2019.04.010"
}
Sakata, D., Lampe, N., Karamitros, M., Kyriakou, I., Belov, O., Bernal, M. A., Bolst, D., Bordage, M., Breton, V., Brown, J. M.C., Francis, Z., Ivanchenko, V., Meylan, S., Murakami, K., Okada, S., Petrović, I. M., Ristić-Fira, A., Santin, G., Sarramia, D., Sasaki, T., Shin, W., Tang, N., Tran, H. N., Villagrasa, C., Emfietzoglou, D., Nieminen, P., Guatelli, S.,& Incerti, S.. (2019). Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. in Physica Medica, 62, 152-157.
https://doi.org/10.1016/j.ejmp.2019.04.010
Sakata D, Lampe N, Karamitros M, Kyriakou I, Belov O, Bernal MA, Bolst D, Bordage M, Breton V, Brown JM, Francis Z, Ivanchenko V, Meylan S, Murakami K, Okada S, Petrović IM, Ristić-Fira A, Santin G, Sarramia D, Sasaki T, Shin W, Tang N, Tran HN, Villagrasa C, Emfietzoglou D, Nieminen P, Guatelli S, Incerti S. Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. in Physica Medica. 2019;62:152-157.
doi:10.1016/j.ejmp.2019.04.010 .
Sakata, Dousatsu, Lampe, Nathanael, Karamitros, Mathieu, Kyriakou, Ioanna, Belov, Oleg, Bernal, Mario A, Bolst, David, Bordage, Marie-Claude, Breton, Vincent, Brown, Jeremy M.C., Francis, Ziad, Ivanchenko, Vladimir, Meylan, Sylvain, Murakami, Koichi, Okada, Shogo, Petrović, Ivan M., Ristić-Fira, Aleksandra, Santin, Giovanni, Sarramia, David, Sasaki, Takashi, Shin, Wook-Geun, Tang, Nicolas, Tran, Hoang N, Villagrasa, Carmen, Emfietzoglou, Dimitris, Nieminen, Petteri, Guatelli, Susanna, Incerti, Sebastien, "Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA" in Physica Medica, 62 (2019):152-157,
https://doi.org/10.1016/j.ejmp.2019.04.010 . .
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The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib

Keta, Otilija D.; Bulat, Tanja M.; Golic, Igor; Incerti, Sebastien; Korać, Aleksandra; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(Springer, 2016)

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Bulat, Tanja M.
AU  - Golic, Igor
AU  - Incerti, Sebastien
AU  - Korać, Aleksandra
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1044
AB  - In most patients with lung cancer radiation treatment is used either as single agent or in combination with radiosensitizing drugs. However, the mechanisms underlying combined therapy and its impact on different modes of cell death have not yet been fully elucidated. We aimed to examine effects of single and combined treatments with gamma-rays and erlotinib on radioresistant CRL-5876 human lung adenocarcinoma cells with particular emphasis on cell death. CRL-5876 cells were treated with gamma-rays and/or erlotinib and changes in cell cycle, DNA repair dynamics, ultrastructure, nuclear morphology and protein expression were monitored at different time points. To reveal the relationship between types of cell death that arise after these treatments, autophagy was blocked with chloroquine. We found that higher dose of gamma-rays causes G2/M arrest while adding of erlotinib to this treatment decreases the number of cells in S phase. Impact of erlotinib on kinetics of disappearance of irradiation-induced DNA double strand breaks is reflected in the increase of residual gamma-H2AX foci after 24 h. gamma-rays provoke cytoprotective autophagy which precedes development of senescence. Erlotinib predominantly induces apoptosis and enlarges the number of apoptotic cells in the irradiated CRL-5876 cells. Chloroquine improved cytotoxicity induced by radiation and erlotinib, increased apoptosis and decreased senescence in the CRL-5876 cells. The results obtained on CRL-5876 cells indicate significant radiosensitizing effect of erlotinib and suggest that chloroquine in the combination with the above treatments may have an additional antitumor effect in lung adenocarcinoma.
PB  - Springer
T2  - Cell Biology and Toxicology
T1  - The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib
VL  - 32
IS  - 2
SP  - 83
EP  - 101
DO  - 10.1007/s10565-016-9319-z
ER  - 
@article{
author = "Keta, Otilija D. and Bulat, Tanja M. and Golic, Igor and Incerti, Sebastien and Korać, Aleksandra and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2016",
abstract = "In most patients with lung cancer radiation treatment is used either as single agent or in combination with radiosensitizing drugs. However, the mechanisms underlying combined therapy and its impact on different modes of cell death have not yet been fully elucidated. We aimed to examine effects of single and combined treatments with gamma-rays and erlotinib on radioresistant CRL-5876 human lung adenocarcinoma cells with particular emphasis on cell death. CRL-5876 cells were treated with gamma-rays and/or erlotinib and changes in cell cycle, DNA repair dynamics, ultrastructure, nuclear morphology and protein expression were monitored at different time points. To reveal the relationship between types of cell death that arise after these treatments, autophagy was blocked with chloroquine. We found that higher dose of gamma-rays causes G2/M arrest while adding of erlotinib to this treatment decreases the number of cells in S phase. Impact of erlotinib on kinetics of disappearance of irradiation-induced DNA double strand breaks is reflected in the increase of residual gamma-H2AX foci after 24 h. gamma-rays provoke cytoprotective autophagy which precedes development of senescence. Erlotinib predominantly induces apoptosis and enlarges the number of apoptotic cells in the irradiated CRL-5876 cells. Chloroquine improved cytotoxicity induced by radiation and erlotinib, increased apoptosis and decreased senescence in the CRL-5876 cells. The results obtained on CRL-5876 cells indicate significant radiosensitizing effect of erlotinib and suggest that chloroquine in the combination with the above treatments may have an additional antitumor effect in lung adenocarcinoma.",
publisher = "Springer",
journal = "Cell Biology and Toxicology",
title = "The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib",
volume = "32",
number = "2",
pages = "83-101",
doi = "10.1007/s10565-016-9319-z"
}
Keta, O. D., Bulat, T. M., Golic, I., Incerti, S., Korać, A., Petrović, I. M.,& Ristić-Fira, A.. (2016). The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib. in Cell Biology and Toxicology
Springer., 32(2), 83-101.
https://doi.org/10.1007/s10565-016-9319-z
Keta OD, Bulat TM, Golic I, Incerti S, Korać A, Petrović IM, Ristić-Fira A. The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib. in Cell Biology and Toxicology. 2016;32(2):83-101.
doi:10.1007/s10565-016-9319-z .
Keta, Otilija D., Bulat, Tanja M., Golic, Igor, Incerti, Sebastien, Korać, Aleksandra, Petrović, Ivan M., Ristić-Fira, Aleksandra, "The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib" in Cell Biology and Toxicology, 32, no. 2 (2016):83-101,
https://doi.org/10.1007/s10565-016-9319-z . .
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17

Recent developments in Geant4

Allison, J; Amako, K; Apostolakis, J; Arce, P; Asai, M; Aso, T; Bagli, E; Bagulya, A; Banerjee, S; Barrand, G; Beck, B.R.; Bogdanov, A.G.; Brandt, D; Brown, J.M.C.; Burkhardt, H; Canal, Ph.; Cano-Ott, D; Chauvie, S; Cho, K; Cirrone, Giuseppe Antonio Pablo; Cooperman, G; Cortés-Giraldo, M.A.; Cosmo, G; Cuttone, Giacomo; Depaola, G; Desorgher, L; Dong, X; Dotti, A; Elvira, V.D.; Folger, G; Francis, Z; Galoyan, A; Garnier, L; Gayer, M; Genser, K.L.; Grichine, V.M.; Guatelli, S; Guèye, P; Gumplinger, P; Howard, A.S.; Hřivnáčová, I; Hwang, S; Incerti, S; Ivanchenko, A.; Ivanchenko, V.N.; Jones, F.W.; Jun, S.Y.; Kaitaniemi, P; Karakatsanis, N; Karamitros, M; Kelsey, M; Kimura, A; Koi, T; Kurashige, H; Lechner, A; Lee, S.B.; Longo, F; Maire, M; Mancusi, D; Mantero, A; Mendoza, E; Morgan, B; Murakami, K; Nikitina, T; Pandola, L; Paprocki, P; Perl, J; Petrović, Ivan M.; Pia, M.G.; Pokorski, W; Quesada, J.M.; Raine, M; Reis, M.A.; Ribon, A; Ristić-Fira, Aleksandra; Romano, Francesco; Russo, G; Santin, G; Sasaki, T; Sawkey, D; Shin, J.I.; Strakovsky, I.I.; Taborda, A; Tanaka, S; Tomé, B; Toshito, T; Tran, H.N.; Truscott, P.R.; Urban, L; Uzhinsky, V; Verbeke, J.M.; Verderi, M; Wendt, B.L.; Wenzel, H; Wright, D.H.; Wright, D.M.; Yamashita, T; Yarba, J; Yoshida, H

(2016)

TY  - JOUR
AU  - Allison, J
AU  - Amako, K
AU  - Apostolakis, J
AU  - Arce, P
AU  - Asai, M
AU  - Aso, T
AU  - Bagli, E
AU  - Bagulya, A
AU  - Banerjee, S
AU  - Barrand, G
AU  - Beck, B.R.
AU  - Bogdanov, A.G.
AU  - Brandt, D
AU  - Brown, J.M.C.
AU  - Burkhardt, H
AU  - Canal, Ph.
AU  - Cano-Ott, D
AU  - Chauvie, S
AU  - Cho, K
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cooperman, G
AU  - Cortés-Giraldo, M.A.
AU  - Cosmo, G
AU  - Cuttone, Giacomo
AU  - Depaola, G
AU  - Desorgher, L
AU  - Dong, X
AU  - Dotti, A
AU  - Elvira, V.D.
AU  - Folger, G
AU  - Francis, Z
AU  - Galoyan, A
AU  - Garnier, L
AU  - Gayer, M
AU  - Genser, K.L.
AU  - Grichine, V.M.
AU  - Guatelli, S
AU  - Guèye, P
AU  - Gumplinger, P
AU  - Howard, A.S.
AU  - Hřivnáčová, I
AU  - Hwang, S
AU  - Incerti, S
AU  - Ivanchenko, A.
AU  - Ivanchenko, V.N.
AU  - Jones, F.W.
AU  - Jun, S.Y.
AU  - Kaitaniemi, P
AU  - Karakatsanis, N
AU  - Karamitros, M
AU  - Kelsey, M
AU  - Kimura, A
AU  - Koi, T
AU  - Kurashige, H
AU  - Lechner, A
AU  - Lee, S.B.
AU  - Longo, F
AU  - Maire, M
AU  - Mancusi, D
AU  - Mantero, A
AU  - Mendoza, E
AU  - Morgan, B
AU  - Murakami, K
AU  - Nikitina, T
AU  - Pandola, L
AU  - Paprocki, P
AU  - Perl, J
AU  - Petrović, Ivan M.
AU  - Pia, M.G.
AU  - Pokorski, W
AU  - Quesada, J.M.
AU  - Raine, M
AU  - Reis, M.A.
AU  - Ribon, A
AU  - Ristić-Fira, Aleksandra
AU  - Romano, Francesco
AU  - Russo, G
AU  - Santin, G
AU  - Sasaki, T
AU  - Sawkey, D
AU  - Shin, J.I.
AU  - Strakovsky, I.I.
AU  - Taborda, A
AU  - Tanaka, S
AU  - Tomé, B
AU  - Toshito, T
AU  - Tran, H.N.
AU  - Truscott, P.R.
AU  - Urban, L
AU  - Uzhinsky, V
AU  - Verbeke, J.M.
AU  - Verderi, M
AU  - Wendt, B.L.
AU  - Wenzel, H
AU  - Wright, D.H.
AU  - Wright, D.M.
AU  - Yamashita, T
AU  - Yarba, J
AU  - Yoshida, H
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8645
AB  - Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here.
T2  - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
T1  - Recent developments in Geant4
VL  - 835
SP  - 186
EP  - 225
DO  - 10.1016/j.nima.2016.06.125
ER  - 
@article{
author = "Allison, J and Amako, K and Apostolakis, J and Arce, P and Asai, M and Aso, T and Bagli, E and Bagulya, A and Banerjee, S and Barrand, G and Beck, B.R. and Bogdanov, A.G. and Brandt, D and Brown, J.M.C. and Burkhardt, H and Canal, Ph. and Cano-Ott, D and Chauvie, S and Cho, K and Cirrone, Giuseppe Antonio Pablo and Cooperman, G and Cortés-Giraldo, M.A. and Cosmo, G and Cuttone, Giacomo and Depaola, G and Desorgher, L and Dong, X and Dotti, A and Elvira, V.D. and Folger, G and Francis, Z and Galoyan, A and Garnier, L and Gayer, M and Genser, K.L. and Grichine, V.M. and Guatelli, S and Guèye, P and Gumplinger, P and Howard, A.S. and Hřivnáčová, I and Hwang, S and Incerti, S and Ivanchenko, A. and Ivanchenko, V.N. and Jones, F.W. and Jun, S.Y. and Kaitaniemi, P and Karakatsanis, N and Karamitros, M and Kelsey, M and Kimura, A and Koi, T and Kurashige, H and Lechner, A and Lee, S.B. and Longo, F and Maire, M and Mancusi, D and Mantero, A and Mendoza, E and Morgan, B and Murakami, K and Nikitina, T and Pandola, L and Paprocki, P and Perl, J and Petrović, Ivan M. and Pia, M.G. and Pokorski, W and Quesada, J.M. and Raine, M and Reis, M.A. and Ribon, A and Ristić-Fira, Aleksandra and Romano, Francesco and Russo, G and Santin, G and Sasaki, T and Sawkey, D and Shin, J.I. and Strakovsky, I.I. and Taborda, A and Tanaka, S and Tomé, B and Toshito, T and Tran, H.N. and Truscott, P.R. and Urban, L and Uzhinsky, V and Verbeke, J.M. and Verderi, M and Wendt, B.L. and Wenzel, H and Wright, D.H. and Wright, D.M. and Yamashita, T and Yarba, J and Yoshida, H",
year = "2016",
abstract = "Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here.",
journal = "Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",
title = "Recent developments in Geant4",
volume = "835",
pages = "186-225",
doi = "10.1016/j.nima.2016.06.125"
}
Allison, J., Amako, K., Apostolakis, J., Arce, P., Asai, M., Aso, T., Bagli, E., Bagulya, A., Banerjee, S., Barrand, G., Beck, B.R., Bogdanov, A.G., Brandt, D., Brown, J.M.C., Burkhardt, H., Canal, Ph., Cano-Ott, D., Chauvie, S., Cho, K., Cirrone, G. A. P., Cooperman, G., Cortés-Giraldo, M.A., Cosmo, G., Cuttone, G., Depaola, G., Desorgher, L., Dong, X., Dotti, A., Elvira, V.D., Folger, G., Francis, Z., Galoyan, A., Garnier, L., Gayer, M., Genser, K.L., Grichine, V.M., Guatelli, S., Guèye, P., Gumplinger, P., Howard, A.S., Hřivnáčová, I., Hwang, S., Incerti, S., Ivanchenko, A., Ivanchenko, V.N., Jones, F.W., Jun, S.Y., Kaitaniemi, P., Karakatsanis, N., Karamitros, M., Kelsey, M., Kimura, A., Koi, T., Kurashige, H., Lechner, A., Lee, S.B., Longo, F., Maire, M., Mancusi, D., Mantero, A., Mendoza, E., Morgan, B., Murakami, K., Nikitina, T., Pandola, L., Paprocki, P., Perl, J., Petrović, I. M., Pia, M.G., Pokorski, W., Quesada, J.M., Raine, M., Reis, M.A., Ribon, A., Ristić-Fira, A., Romano, F., Russo, G., Santin, G., Sasaki, T., Sawkey, D., Shin, J.I., Strakovsky, I.I., Taborda, A., Tanaka, S., Tomé, B., Toshito, T., Tran, H.N., Truscott, P.R., Urban, L., Uzhinsky, V., Verbeke, J.M., Verderi, M., Wendt, B.L., Wenzel, H., Wright, D.H., Wright, D.M., Yamashita, T., Yarba, J.,& Yoshida, H.. (2016). Recent developments in Geant4. in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 835, 186-225.
https://doi.org/10.1016/j.nima.2016.06.125
Allison J, Amako K, Apostolakis J, Arce P, Asai M, Aso T, Bagli E, Bagulya A, Banerjee S, Barrand G, Beck B, Bogdanov A, Brandt D, Brown J, Burkhardt H, Canal P, Cano-Ott D, Chauvie S, Cho K, Cirrone GAP, Cooperman G, Cortés-Giraldo M, Cosmo G, Cuttone G, Depaola G, Desorgher L, Dong X, Dotti A, Elvira V, Folger G, Francis Z, Galoyan A, Garnier L, Gayer M, Genser K, Grichine V, Guatelli S, Guèye P, Gumplinger P, Howard A, Hřivnáčová I, Hwang S, Incerti S, Ivanchenko A, Ivanchenko V, Jones F, Jun S, Kaitaniemi P, Karakatsanis N, Karamitros M, Kelsey M, Kimura A, Koi T, Kurashige H, Lechner A, Lee S, Longo F, Maire M, Mancusi D, Mantero A, Mendoza E, Morgan B, Murakami K, Nikitina T, Pandola L, Paprocki P, Perl J, Petrović IM, Pia M, Pokorski W, Quesada J, Raine M, Reis M, Ribon A, Ristić-Fira A, Romano F, Russo G, Santin G, Sasaki T, Sawkey D, Shin J, Strakovsky I, Taborda A, Tanaka S, Tomé B, Toshito T, Tran H, Truscott P, Urban L, Uzhinsky V, Verbeke J, Verderi M, Wendt B, Wenzel H, Wright D, Wright D, Yamashita T, Yarba J, Yoshida H. Recent developments in Geant4. in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2016;835:186-225.
doi:10.1016/j.nima.2016.06.125 .
Allison, J, Amako, K, Apostolakis, J, Arce, P, Asai, M, Aso, T, Bagli, E, Bagulya, A, Banerjee, S, Barrand, G, Beck, B.R., Bogdanov, A.G., Brandt, D, Brown, J.M.C., Burkhardt, H, Canal, Ph., Cano-Ott, D, Chauvie, S, Cho, K, Cirrone, Giuseppe Antonio Pablo, Cooperman, G, Cortés-Giraldo, M.A., Cosmo, G, Cuttone, Giacomo, Depaola, G, Desorgher, L, Dong, X, Dotti, A, Elvira, V.D., Folger, G, Francis, Z, Galoyan, A, Garnier, L, Gayer, M, Genser, K.L., Grichine, V.M., Guatelli, S, Guèye, P, Gumplinger, P, Howard, A.S., Hřivnáčová, I, Hwang, S, Incerti, S, Ivanchenko, A., Ivanchenko, V.N., Jones, F.W., Jun, S.Y., Kaitaniemi, P, Karakatsanis, N, Karamitros, M, Kelsey, M, Kimura, A, Koi, T, Kurashige, H, Lechner, A, Lee, S.B., Longo, F, Maire, M, Mancusi, D, Mantero, A, Mendoza, E, Morgan, B, Murakami, K, Nikitina, T, Pandola, L, Paprocki, P, Perl, J, Petrović, Ivan M., Pia, M.G., Pokorski, W, Quesada, J.M., Raine, M, Reis, M.A., Ribon, A, Ristić-Fira, Aleksandra, Romano, Francesco, Russo, G, Santin, G, Sasaki, T, Sawkey, D, Shin, J.I., Strakovsky, I.I., Taborda, A, Tanaka, S, Tomé, B, Toshito, T, Tran, H.N., Truscott, P.R., Urban, L, Uzhinsky, V, Verbeke, J.M., Verderi, M, Wendt, B.L., Wenzel, H, Wright, D.H., Wright, D.M., Yamashita, T, Yarba, J, Yoshida, H, "Recent developments in Geant4" in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 835 (2016):186-225,
https://doi.org/10.1016/j.nima.2016.06.125 . .
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1549

Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit

Bernal, Mario A.; Bordage, Marie Claude; Brown, Jeremy Michael Cooney; Davídková, Marie; Delage, E.; El Bitar, Ziad Ei; Enger, Shirin A.; Francis, Ziad; Guatelli, Susanna; Ivanchenko, Vladimir N.; Karamitros, Mathieu; Kyriakou, Ioanna; Maigne, Lydia; Meylan, S.; Murakami, Kouichi; Okada, Shogo; Payno, H.; Perrot, Yann; Petrović, Ivan M.; Pham, Q. T.; Ristić-Fira, Aleksandra; Sasaki, Takashi; Stepan, Vaclav; Tran, Hoang Ngoc; Villagrasa, Carmen; Incerti, Sebastien

(Elsevier, 2015)

TY  - JOUR
AU  - Bernal, Mario A.
AU  - Bordage, Marie Claude
AU  - Brown, Jeremy Michael Cooney
AU  - Davídková, Marie
AU  - Delage, E.
AU  - El Bitar, Ziad Ei
AU  - Enger, Shirin A.
AU  - Francis, Ziad
AU  - Guatelli, Susanna
AU  - Ivanchenko, Vladimir N.
AU  - Karamitros, Mathieu
AU  - Kyriakou, Ioanna
AU  - Maigne, Lydia
AU  - Meylan, S.
AU  - Murakami, Kouichi
AU  - Okada, Shogo
AU  - Payno, H.
AU  - Perrot, Yann
AU  - Petrović, Ivan M.
AU  - Pham, Q. T.
AU  - Ristić-Fira, Aleksandra
AU  - Sasaki, Takashi
AU  - Stepan, Vaclav
AU  - Tran, Hoang Ngoc
AU  - Villagrasa, Carmen
AU  - Incerti, Sebastien
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/859
AB  - Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of todays radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described. (C) 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Physica Medica -European Journal of Medical Physics
T1  - Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit
VL  - 31
IS  - 8
SP  - 861
EP  - 874
DO  - 10.1016/j.ejmp.2015.10.087
ER  - 
@article{
author = "Bernal, Mario A. and Bordage, Marie Claude and Brown, Jeremy Michael Cooney and Davídková, Marie and Delage, E. and El Bitar, Ziad Ei and Enger, Shirin A. and Francis, Ziad and Guatelli, Susanna and Ivanchenko, Vladimir N. and Karamitros, Mathieu and Kyriakou, Ioanna and Maigne, Lydia and Meylan, S. and Murakami, Kouichi and Okada, Shogo and Payno, H. and Perrot, Yann and Petrović, Ivan M. and Pham, Q. T. and Ristić-Fira, Aleksandra and Sasaki, Takashi and Stepan, Vaclav and Tran, Hoang Ngoc and Villagrasa, Carmen and Incerti, Sebastien",
year = "2015",
abstract = "Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of todays radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described. (C) 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Physica Medica -European Journal of Medical Physics",
title = "Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit",
volume = "31",
number = "8",
pages = "861-874",
doi = "10.1016/j.ejmp.2015.10.087"
}
Bernal, M. A., Bordage, M. C., Brown, J. M. C., Davídková, M., Delage, E., El Bitar, Z. E., Enger, S. A., Francis, Z., Guatelli, S., Ivanchenko, V. N., Karamitros, M., Kyriakou, I., Maigne, L., Meylan, S., Murakami, K., Okada, S., Payno, H., Perrot, Y., Petrović, I. M., Pham, Q. T., Ristić-Fira, A., Sasaki, T., Stepan, V., Tran, H. N., Villagrasa, C.,& Incerti, S.. (2015). Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit. in Physica Medica -European Journal of Medical Physics
Elsevier., 31(8), 861-874.
https://doi.org/10.1016/j.ejmp.2015.10.087
Bernal MA, Bordage MC, Brown JMC, Davídková M, Delage E, El Bitar ZE, Enger SA, Francis Z, Guatelli S, Ivanchenko VN, Karamitros M, Kyriakou I, Maigne L, Meylan S, Murakami K, Okada S, Payno H, Perrot Y, Petrović IM, Pham QT, Ristić-Fira A, Sasaki T, Stepan V, Tran HN, Villagrasa C, Incerti S. Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit. in Physica Medica -European Journal of Medical Physics. 2015;31(8):861-874.
doi:10.1016/j.ejmp.2015.10.087 .
Bernal, Mario A., Bordage, Marie Claude, Brown, Jeremy Michael Cooney, Davídková, Marie, Delage, E., El Bitar, Ziad Ei, Enger, Shirin A., Francis, Ziad, Guatelli, Susanna, Ivanchenko, Vladimir N., Karamitros, Mathieu, Kyriakou, Ioanna, Maigne, Lydia, Meylan, S., Murakami, Kouichi, Okada, Shogo, Payno, H., Perrot, Yann, Petrović, Ivan M., Pham, Q. T., Ristić-Fira, Aleksandra, Sasaki, Takashi, Stepan, Vaclav, Tran, Hoang Ngoc, Villagrasa, Carmen, Incerti, Sebastien, "Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit" in Physica Medica -European Journal of Medical Physics, 31, no. 8 (2015):861-874,
https://doi.org/10.1016/j.ejmp.2015.10.087 . .
4
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265

Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study

Incerti, Sebastien; Psaltaki, M.; Gillet, P.; Barberet, Ph.; Bardies, M.; Bernal, Mario A.; Bordage, M. -C.; Breton, V.; Davídková, Marie; Delage, E.; El Bitar, Ziad Ei; Francis, Ziad; Guatelli, Susanna; Ivanchenko, A.; Ivanchenko, V.; Karamitros, Mathieu; Lee, S. B.; Maigne, Lydia; Meylan, S.; Murakami, Kouichi; Nieminen, P.; Payno, H.; Perrot, Yann; Petrović, Ivan M.; Pham, Q. T.; Ristić-Fira, Aleksandra; Santin, G.; Sasaki, Takashi; Seznec, H.; Shin, J. I.; Stepan, Vaclav; Tran, Hoang Ngoc; Villagrasa, Carmen; Geant4-DNA Collaboration

(2014)

TY  - JOUR
AU  - Incerti, Sebastien
AU  - Psaltaki, M.
AU  - Gillet, P.
AU  - Barberet, Ph.
AU  - Bardies, M.
AU  - Bernal, Mario A.
AU  - Bordage, M. -C.
AU  - Breton, V.
AU  - Davídková, Marie
AU  - Delage, E.
AU  - El Bitar, Ziad Ei
AU  - Francis, Ziad
AU  - Guatelli, Susanna
AU  - Ivanchenko, A.
AU  - Ivanchenko, V.
AU  - Karamitros, Mathieu
AU  - Lee, S. B.
AU  - Maigne, Lydia
AU  - Meylan, S.
AU  - Murakami, Kouichi
AU  - Nieminen, P.
AU  - Payno, H.
AU  - Perrot, Yann
AU  - Petrović, Ivan M.
AU  - Pham, Q. T.
AU  - Ristić-Fira, Aleksandra
AU  - Santin, G.
AU  - Sasaki, Takashi
AU  - Seznec, H.
AU  - Shin, J. I.
AU  - Stepan, Vaclav
AU  - Tran, Hoang Ngoc
AU  - Villagrasa, Carmen
AU  - Geant4-DNA Collaboration
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6073
AB  - An accurate modeling of radial energy deposition around ion tracks is a key requirement of radiation transport software used for simulations in radiobiology at the sub-cellular scale. The work presented in this paper is part of the on-going benchmarking of the Geant4-DNA physics processes and models, which are available in the Geant4 Monte Carlo simulation toolkit for the low energy transport of particles in liquid water. We present for the first time radial dose distributions of incident ion tracks simulated with Geant4-DNA. Simulation results are compared to other results available in the literature, obtained from analytical calculations, step-by-step Monte Carlo simulations and measurements. They show a reasonable agreement with reference data. (C) 2014 Elsevier B.V. All rights reserved.
T2  - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
T1  - Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study
VL  - 333
SP  - 92
EP  - 98
DO  - 10.1016/j.nimb.2014.04.025
ER  - 
@article{
author = "Incerti, Sebastien and Psaltaki, M. and Gillet, P. and Barberet, Ph. and Bardies, M. and Bernal, Mario A. and Bordage, M. -C. and Breton, V. and Davídková, Marie and Delage, E. and El Bitar, Ziad Ei and Francis, Ziad and Guatelli, Susanna and Ivanchenko, A. and Ivanchenko, V. and Karamitros, Mathieu and Lee, S. B. and Maigne, Lydia and Meylan, S. and Murakami, Kouichi and Nieminen, P. and Payno, H. and Perrot, Yann and Petrović, Ivan M. and Pham, Q. T. and Ristić-Fira, Aleksandra and Santin, G. and Sasaki, Takashi and Seznec, H. and Shin, J. I. and Stepan, Vaclav and Tran, Hoang Ngoc and Villagrasa, Carmen and Geant4-DNA Collaboration",
year = "2014",
abstract = "An accurate modeling of radial energy deposition around ion tracks is a key requirement of radiation transport software used for simulations in radiobiology at the sub-cellular scale. The work presented in this paper is part of the on-going benchmarking of the Geant4-DNA physics processes and models, which are available in the Geant4 Monte Carlo simulation toolkit for the low energy transport of particles in liquid water. We present for the first time radial dose distributions of incident ion tracks simulated with Geant4-DNA. Simulation results are compared to other results available in the literature, obtained from analytical calculations, step-by-step Monte Carlo simulations and measurements. They show a reasonable agreement with reference data. (C) 2014 Elsevier B.V. All rights reserved.",
journal = "Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms",
title = "Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study",
volume = "333",
pages = "92-98",
doi = "10.1016/j.nimb.2014.04.025"
}
Incerti, S., Psaltaki, M., Gillet, P., Barberet, Ph., Bardies, M., Bernal, M. A., Bordage, M. -C., Breton, V., Davídková, M., Delage, E., El Bitar, Z. E., Francis, Z., Guatelli, S., Ivanchenko, A., Ivanchenko, V., Karamitros, M., Lee, S. B., Maigne, L., Meylan, S., Murakami, K., Nieminen, P., Payno, H., Perrot, Y., Petrović, I. M., Pham, Q. T., Ristić-Fira, A., Santin, G., Sasaki, T., Seznec, H., Shin, J. I., Stepan, V., Tran, H. N., Villagrasa, C.,& Geant4-DNA Collaboration. (2014). Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study. in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 333, 92-98.
https://doi.org/10.1016/j.nimb.2014.04.025
Incerti S, Psaltaki M, Gillet P, Barberet P, Bardies M, Bernal MA, Bordage M-, Breton V, Davídková M, Delage E, El Bitar ZE, Francis Z, Guatelli S, Ivanchenko A, Ivanchenko V, Karamitros M, Lee SB, Maigne L, Meylan S, Murakami K, Nieminen P, Payno H, Perrot Y, Petrović IM, Pham QT, Ristić-Fira A, Santin G, Sasaki T, Seznec H, Shin JI, Stepan V, Tran HN, Villagrasa C, Geant4-DNA Collaboration. Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study. in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. 2014;333:92-98.
doi:10.1016/j.nimb.2014.04.025 .
Incerti, Sebastien, Psaltaki, M., Gillet, P., Barberet, Ph., Bardies, M., Bernal, Mario A., Bordage, M. -C., Breton, V., Davídková, Marie, Delage, E., El Bitar, Ziad Ei, Francis, Ziad, Guatelli, Susanna, Ivanchenko, A., Ivanchenko, V., Karamitros, Mathieu, Lee, S. B., Maigne, Lydia, Meylan, S., Murakami, Kouichi, Nieminen, P., Payno, H., Perrot, Yann, Petrović, Ivan M., Pham, Q. T., Ristić-Fira, Aleksandra, Santin, G., Sasaki, Takashi, Seznec, H., Shin, J. I., Stepan, Vaclav, Tran, Hoang Ngoc, Villagrasa, Carmen, Geant4-DNA Collaboration, "Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study" in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 333 (2014):92-98,
https://doi.org/10.1016/j.nimb.2014.04.025 . .
34
32
32

Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces

Ivanchenko, Vladimir; Apostolakis, John; Bagulya, Alexander; Abdelouahed, Haifa Ben; Black, Rachel; Bogdanov, Alexey; Burkhard, Helmut; Chauvie, Stéphane; Cirrone, Giuseppe Antonio Pablo; Cuttone, Giacomo; Depaola, Gerardo; Di Rosa, Francesco; Elles, Sabine; Francis, Ziad; Grichine, Vladimir; Gumplinger, Peter; Gueye, Paul; Incerti, Sebastien; Ivanchenko, Anton; Jacquemier, Jean; Lechner, Anton; Longo, Francesco; Kadri, Omrane; Karakatsanis, Nicolas; Karamitros, Mathieu; Kokoulin, Rostislav; Kurashige, Hisaya; Maire, Michel; Mantero, Alfonso; Mascialino, Barbara; Moscicki, Jakub; Pandola, Luciano; Perl, Joseph; Petrović, Ivan M.; Ristić-Fira, Aleksandra; Romano, Francesco; Russo, Giorgio; Santin, Giovanni; Schaelicke, Andreas; Toshito, Toshiyuki; Tran, Hoang; Urban, Laszlo; Yamashita, Tomohiro; Zacharatou, Christina

(2011)

TY  - JOUR
AU  - Ivanchenko, Vladimir
AU  - Apostolakis, John
AU  - Bagulya, Alexander
AU  - Abdelouahed, Haifa Ben
AU  - Black, Rachel
AU  - Bogdanov, Alexey
AU  - Burkhard, Helmut
AU  - Chauvie, Stéphane
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Depaola, Gerardo
AU  - Di Rosa, Francesco
AU  - Elles, Sabine
AU  - Francis, Ziad
AU  - Grichine, Vladimir
AU  - Gumplinger, Peter
AU  - Gueye, Paul
AU  - Incerti, Sebastien
AU  - Ivanchenko, Anton
AU  - Jacquemier, Jean
AU  - Lechner, Anton
AU  - Longo, Francesco
AU  - Kadri, Omrane
AU  - Karakatsanis, Nicolas
AU  - Karamitros, Mathieu
AU  - Kokoulin, Rostislav
AU  - Kurashige, Hisaya
AU  - Maire, Michel
AU  - Mantero, Alfonso
AU  - Mascialino, Barbara
AU  - Moscicki, Jakub
AU  - Pandola, Luciano
AU  - Perl, Joseph
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Romano, Francesco
AU  - Russo, Giorgio
AU  - Santin, Giovanni
AU  - Schaelicke, Andreas
AU  - Toshito, Toshiyuki
AU  - Tran, Hoang
AU  - Urban, Laszlo
AU  - Yamashita, Tomohiro
AU  - Zacharatou, Christina
PY  - 2011
UR  - http://inis.iaea.org/search/search.aspx?orig_q=RN:49057834
UR  - http://www.aesj.or.jp/publication/pnst002/data/898-903.pdf
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8641
AB  - An overview of the electromagnetic (EM) physics of the Geant4 toolkit is presented Two sets of EM models are available: the 'Standard' initially focused on high energy physics (HEP) while the 'Low-energy' was developed for medical, space and other applications The 'Standard' models provide a faster computation but are less accurate for keV energies, the 'Low-energy' models are more CPU time consuming A common interface to EM physics models has been developed allowing a natural combination of ultra-relativistic, relativistic and low-energy models for the same run providing both precision and CPU performance Due to this migration additional capabilities become available The new developments include relativistic models for bremsstrahlung and e+e- pair production, models of multiple and single scattering, hadron/ion ionization, microdosimetry for very low energies and also improvements in existing Geant4 models In parallel, validation suites and benchmarks have been intensively developed (author)
T2  - Progress in Nuclear Science and Technology
T1  - Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces
VL  - 2
SP  - 898
EP  - 903
DO  - 10.15669/pnst.2.898
ER  - 
@article{
author = "Ivanchenko, Vladimir and Apostolakis, John and Bagulya, Alexander and Abdelouahed, Haifa Ben and Black, Rachel and Bogdanov, Alexey and Burkhard, Helmut and Chauvie, Stéphane and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Depaola, Gerardo and Di Rosa, Francesco and Elles, Sabine and Francis, Ziad and Grichine, Vladimir and Gumplinger, Peter and Gueye, Paul and Incerti, Sebastien and Ivanchenko, Anton and Jacquemier, Jean and Lechner, Anton and Longo, Francesco and Kadri, Omrane and Karakatsanis, Nicolas and Karamitros, Mathieu and Kokoulin, Rostislav and Kurashige, Hisaya and Maire, Michel and Mantero, Alfonso and Mascialino, Barbara and Moscicki, Jakub and Pandola, Luciano and Perl, Joseph and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Romano, Francesco and Russo, Giorgio and Santin, Giovanni and Schaelicke, Andreas and Toshito, Toshiyuki and Tran, Hoang and Urban, Laszlo and Yamashita, Tomohiro and Zacharatou, Christina",
year = "2011",
abstract = "An overview of the electromagnetic (EM) physics of the Geant4 toolkit is presented Two sets of EM models are available: the 'Standard' initially focused on high energy physics (HEP) while the 'Low-energy' was developed for medical, space and other applications The 'Standard' models provide a faster computation but are less accurate for keV energies, the 'Low-energy' models are more CPU time consuming A common interface to EM physics models has been developed allowing a natural combination of ultra-relativistic, relativistic and low-energy models for the same run providing both precision and CPU performance Due to this migration additional capabilities become available The new developments include relativistic models for bremsstrahlung and e+e- pair production, models of multiple and single scattering, hadron/ion ionization, microdosimetry for very low energies and also improvements in existing Geant4 models In parallel, validation suites and benchmarks have been intensively developed (author)",
journal = "Progress in Nuclear Science and Technology",
title = "Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces",
volume = "2",
pages = "898-903",
doi = "10.15669/pnst.2.898"
}
Ivanchenko, V., Apostolakis, J., Bagulya, A., Abdelouahed, H. B., Black, R., Bogdanov, A., Burkhard, H., Chauvie, S., Cirrone, G. A. P., Cuttone, G., Depaola, G., Di Rosa, F., Elles, S., Francis, Z., Grichine, V., Gumplinger, P., Gueye, P., Incerti, S., Ivanchenko, A., Jacquemier, J., Lechner, A., Longo, F., Kadri, O., Karakatsanis, N., Karamitros, M., Kokoulin, R., Kurashige, H., Maire, M., Mantero, A., Mascialino, B., Moscicki, J., Pandola, L., Perl, J., Petrović, I. M., Ristić-Fira, A., Romano, F., Russo, G., Santin, G., Schaelicke, A., Toshito, T., Tran, H., Urban, L., Yamashita, T.,& Zacharatou, C.. (2011). Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces. in Progress in Nuclear Science and Technology, 2, 898-903.
https://doi.org/10.15669/pnst.2.898
Ivanchenko V, Apostolakis J, Bagulya A, Abdelouahed HB, Black R, Bogdanov A, Burkhard H, Chauvie S, Cirrone GAP, Cuttone G, Depaola G, Di Rosa F, Elles S, Francis Z, Grichine V, Gumplinger P, Gueye P, Incerti S, Ivanchenko A, Jacquemier J, Lechner A, Longo F, Kadri O, Karakatsanis N, Karamitros M, Kokoulin R, Kurashige H, Maire M, Mantero A, Mascialino B, Moscicki J, Pandola L, Perl J, Petrović IM, Ristić-Fira A, Romano F, Russo G, Santin G, Schaelicke A, Toshito T, Tran H, Urban L, Yamashita T, Zacharatou C. Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces. in Progress in Nuclear Science and Technology. 2011;2:898-903.
doi:10.15669/pnst.2.898 .
Ivanchenko, Vladimir, Apostolakis, John, Bagulya, Alexander, Abdelouahed, Haifa Ben, Black, Rachel, Bogdanov, Alexey, Burkhard, Helmut, Chauvie, Stéphane, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Depaola, Gerardo, Di Rosa, Francesco, Elles, Sabine, Francis, Ziad, Grichine, Vladimir, Gumplinger, Peter, Gueye, Paul, Incerti, Sebastien, Ivanchenko, Anton, Jacquemier, Jean, Lechner, Anton, Longo, Francesco, Kadri, Omrane, Karakatsanis, Nicolas, Karamitros, Mathieu, Kokoulin, Rostislav, Kurashige, Hisaya, Maire, Michel, Mantero, Alfonso, Mascialino, Barbara, Moscicki, Jakub, Pandola, Luciano, Perl, Joseph, Petrović, Ivan M., Ristić-Fira, Aleksandra, Romano, Francesco, Russo, Giorgio, Santin, Giovanni, Schaelicke, Andreas, Toshito, Toshiyuki, Tran, Hoang, Urban, Laszlo, Yamashita, Tomohiro, Zacharatou, Christina, "Recent Improvements in Geant4 Electromagnetic Physics Models and Interfaces" in Progress in Nuclear Science and Technology, 2 (2011):898-903,
https://doi.org/10.15669/pnst.2.898 . .
79