Chanda, Sanjoy K.

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  • Chanda, Sanjoy K. (1)
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Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study

Gogoi, Roktim; Begum, Twahira; Sarma, Neelav; Tamang, Raghu; Chanda, Sanjoy K.; Lal, Mohan; Perveen, Kahkashan; Khan, Faheema; Marinković, Jelena

(2024) 

TY  - JOUR
AU  - Gogoi, Roktim
AU  - Begum, Twahira
AU  - Sarma, Neelav
AU  - Tamang, Raghu
AU  - Chanda, Sanjoy K.
AU  - Lal, Mohan
AU  - Perveen, Kahkashan
AU  - Khan, Faheema
AU  - Marinković, Jelena
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13099
AB  - Pelargonium graveolens L., essential oil (EO) has various therapeutic properties, including aromatherapy. The present experiment was designed to investigate chemical makeup of the P. graveolens (Geranium) EO from Northeast India using gas chromatography-mass spectroscopy (GC-MS) and gas chromatography-flame ionization detection (GC-FID), and the pharmacological potential was determined using a range of assays along with Allium cepa assay for genotoxicity study. GC-MS analysis of the EO revealed the presence of 11 compounds with a total 97.43% identified area, with citronellol (32.84%), geraniol (23.62%), and citronellyl formate (12.14%) as the major compounds. The essential oil exhibited type-II anti-diabetic properties with an IC50 6.66 μL/mL and skin whitening potential IC50 of 1.89 μL/mL. P. graveolens EO (IC50 26.16 μL/mL) was found to possess comparatively weaker anti-inflammatory agent than the standard diclofenac (IC50 9.24 μL/mL) in the protease inhibitory test. The EO demonstrated moderate antioxidant activity with an IC50 value of 22.68 μL/mL than ascorbic acid IC50 12.53 μL/mL in the ABTS assay. The EO was found to moderately affect the mitotic index (15.32%) and induce chromosomal aberrations (11.40%) at a concentration of 1 μL/mL after 72 h of exposure. Based on the findings the Northeast Indian variety of P. graveolens EO exhibits promising type-II anti-diabetic and skin whitening properties, which could be further utilized in the formulation of anti-diabetic and skin whitening agents after validation through clinical trials.
T2  - Journal of Essential Oil Bearing Plants
T1  - Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study
VL  - 27
IS  - 1
SP  - 135
EP  - 151
DO  - 10.1080/0972060X.2024.2311825
ER  - 
@article{
author = "Gogoi, Roktim and Begum, Twahira and Sarma, Neelav and Tamang, Raghu and Chanda, Sanjoy K. and Lal, Mohan and Perveen, Kahkashan and Khan, Faheema and Marinković, Jelena",
year = "2024",
abstract = "Pelargonium graveolens L., essential oil (EO) has various therapeutic properties, including aromatherapy. The present experiment was designed to investigate chemical makeup of the P. graveolens (Geranium) EO from Northeast India using gas chromatography-mass spectroscopy (GC-MS) and gas chromatography-flame ionization detection (GC-FID), and the pharmacological potential was determined using a range of assays along with Allium cepa assay for genotoxicity study. GC-MS analysis of the EO revealed the presence of 11 compounds with a total 97.43% identified area, with citronellol (32.84%), geraniol (23.62%), and citronellyl formate (12.14%) as the major compounds. The essential oil exhibited type-II anti-diabetic properties with an IC50 6.66 μL/mL and skin whitening potential IC50 of 1.89 μL/mL. P. graveolens EO (IC50 26.16 μL/mL) was found to possess comparatively weaker anti-inflammatory agent than the standard diclofenac (IC50 9.24 μL/mL) in the protease inhibitory test. The EO demonstrated moderate antioxidant activity with an IC50 value of 22.68 μL/mL than ascorbic acid IC50 12.53 μL/mL in the ABTS assay. The EO was found to moderately affect the mitotic index (15.32%) and induce chromosomal aberrations (11.40%) at a concentration of 1 μL/mL after 72 h of exposure. Based on the findings the Northeast Indian variety of P. graveolens EO exhibits promising type-II anti-diabetic and skin whitening properties, which could be further utilized in the formulation of anti-diabetic and skin whitening agents after validation through clinical trials.",
journal = "Journal of Essential Oil Bearing Plants",
title = "Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study",
volume = "27",
number = "1",
pages = "135-151",
doi = "10.1080/0972060X.2024.2311825"
}
Gogoi, R., Begum, T., Sarma, N., Tamang, R., Chanda, S. K., Lal, M., Perveen, K., Khan, F.,& Marinković, J.. (2024). Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study. in Journal of Essential Oil Bearing Plants, 27(1), 135-151.
https://doi.org/10.1080/0972060X.2024.2311825
Gogoi R, Begum T, Sarma N, Tamang R, Chanda SK, Lal M, Perveen K, Khan F, Marinković J. Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study. in Journal of Essential Oil Bearing Plants. 2024;27(1):135-151.
doi:10.1080/0972060X.2024.2311825 .
Gogoi, Roktim, Begum, Twahira, Sarma, Neelav, Tamang, Raghu, Chanda, Sanjoy K., Lal, Mohan, Perveen, Kahkashan, Khan, Faheema, Marinković, Jelena, "Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study" in Journal of Essential Oil Bearing Plants, 27, no. 1 (2024):135-151,
https://doi.org/10.1080/0972060X.2024.2311825 . .
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