TY  - JOUR
AU  - Laban, Bojana B.
AU  - Novaković, Mirjana
AU  - Vasić-Anićijević, Dragana
AU  - Bondžić, Aleksandra M.
AU  - Vujačić Nikezić, Ana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12442
AB  - Indocyanine green (ICG) is the FDA-approved fluorescent dye used for in vivo medical imaging, diagnostics, and photothermal therapy. However, this dye is easily degradable in the human vascular system, and therefore its stabilization is preferable. In this work, ICG molecules were stabilized by their adsorption on the surface of the L-methionine-capped Ag and Au nanoparticles (Ag and Au @LM NPs) in aqueous colloidal dispersions. The result is the formation of hybrid metal core/ICG shell NPs in colloidal dispersions. Additionally, colloidal dispersions were stabilized, indicating a double effect of ICG adsorption. The obtained hybrid NPs were studied experimentally (UV–Vis spectrophotometry, HRTEM, DLS, FTIR) and theoretically (DFT calculations). HRTEM revealed that the interplanar spacing between adjacent planes of NPs decreases after the dye adsorption. The results obtained from the DFT study confirmed the formation of a covalent bond between the oxygen from ICG dye SO3− group and metal NPs. Considering the characteristics of both components of the NPs/ICG hybrid system, the authors assume that this hybrid system can exhibit the synergistic effect that could lead to more successful theranostic treatment of cancer in nanomedicine.
T2  - Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
T1  - A combined experimental and DFT study of metal core/indocyanine green shell hybrid nanoparticles
VL  - 309
SP  - 123828
DO  - 10.1016/j.saa.2023.123828
ER  - 

@article{
author = "Laban, Bojana B. and Novaković, Mirjana and Vasić-Anićijević, Dragana and Bondžić, Aleksandra M. and Vujačić Nikezić, Ana",
year = "2024",
abstract = "Indocyanine green (ICG) is the FDA-approved fluorescent dye used for in vivo medical imaging, diagnostics, and photothermal therapy. However, this dye is easily degradable in the human vascular system, and therefore its stabilization is preferable. In this work, ICG molecules were stabilized by their adsorption on the surface of the L-methionine-capped Ag and Au nanoparticles (Ag and Au @LM NPs) in aqueous colloidal dispersions. The result is the formation of hybrid metal core/ICG shell NPs in colloidal dispersions. Additionally, colloidal dispersions were stabilized, indicating a double effect of ICG adsorption. The obtained hybrid NPs were studied experimentally (UV–Vis spectrophotometry, HRTEM, DLS, FTIR) and theoretically (DFT calculations). HRTEM revealed that the interplanar spacing between adjacent planes of NPs decreases after the dye adsorption. The results obtained from the DFT study confirmed the formation of a covalent bond between the oxygen from ICG dye SO3− group and metal NPs. Considering the characteristics of both components of the NPs/ICG hybrid system, the authors assume that this hybrid system can exhibit the synergistic effect that could lead to more successful theranostic treatment of cancer in nanomedicine.",
journal = "Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy",
title = "A combined experimental and DFT study of metal core/indocyanine green shell hybrid nanoparticles",
volume = "309",
pages = "123828",
doi = "10.1016/j.saa.2023.123828"
}

Laban, B. B., Novaković, M., Vasić-Anićijević, D., Bondžić, A. M.,& Vujačić Nikezić, A.. (2024). A combined experimental and DFT study of metal core/indocyanine green shell hybrid nanoparticles. in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 309, 123828.
https://doi.org/10.1016/j.saa.2023.123828

Laban BB, Novaković M, Vasić-Anićijević D, Bondžić AM, Vujačić Nikezić A. A combined experimental and DFT study of metal core/indocyanine green shell hybrid nanoparticles. in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2024;309:123828.
doi:10.1016/j.saa.2023.123828 .

Laban, Bojana B., Novaković, Mirjana, Vasić-Anićijević, Dragana, Bondžić, Aleksandra M., Vujačić Nikezić, Ana, "A combined experimental and DFT study of metal core/indocyanine green shell hybrid nanoparticles" in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 309 (2024):123828,
https://doi.org/10.1016/j.saa.2023.123828 . .

TY  - JOUR
AU  - Jovanović, Dunja
AU  - Filipović, Ana
AU  - Janjić, Goran
AU  - Lazarević-Pašti, Tamara
AU  - Džambaski, Zdravko
AU  - Bondžić, Bojan
AU  - Bondžić, Aleksandra
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12450
AB  - We have synthesized 22 C-1 functionalized-N-aryl-1,2,3,4-tetrahydroisoquinoline derivatives showing biological activities towards cholinergic enzymes. Synthesis was performed using visible-light-promoted photo-redox chemistry, starting from a common intermediate, and the application of this synthetic methodology drastically simplified synthetic routes and purification of desired compounds. All synthesized derivates were divided into four groups based on the substituents in the C-1 position, and their inhibition potencies towards two cholinergic enzymes, acetyl- and butyrylcholinesterase were evaluated. Most potent derivatives were selected, and kinetic analysis was further carried out to obtain insights into the mechanisms of inhibition of these two enzymes. Further validation of the mode of inhibition of cholinergic enzymes by the two most potent THIQ compounds, 3c and 3i, was performed using fluorescence-quenching titration studies. Molecular docking studies further confirmed the proposed mechanism of enzymes’ inhibition. In silico predictions of physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of the selected most potent derivatives were performed using Swiss ADME tool. This was followed by UPLC-assisted log P determination and in vitro BBB permeability studies performed in order to assess the potential of the synthesized compounds to pass the BBB.
T2  - International Journal of Molecular Sciences
T1  - Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates
VL  - 25
IS  - 2
SP  - 1033
DO  - 10.3390/ijms25021033
ER  - 

@article{
author = "Jovanović, Dunja and Filipović, Ana and Janjić, Goran and Lazarević-Pašti, Tamara and Džambaski, Zdravko and Bondžić, Bojan and Bondžić, Aleksandra",
year = "2024",
abstract = "We have synthesized 22 C-1 functionalized-N-aryl-1,2,3,4-tetrahydroisoquinoline derivatives showing biological activities towards cholinergic enzymes. Synthesis was performed using visible-light-promoted photo-redox chemistry, starting from a common intermediate, and the application of this synthetic methodology drastically simplified synthetic routes and purification of desired compounds. All synthesized derivates were divided into four groups based on the substituents in the C-1 position, and their inhibition potencies towards two cholinergic enzymes, acetyl- and butyrylcholinesterase were evaluated. Most potent derivatives were selected, and kinetic analysis was further carried out to obtain insights into the mechanisms of inhibition of these two enzymes. Further validation of the mode of inhibition of cholinergic enzymes by the two most potent THIQ compounds, 3c and 3i, was performed using fluorescence-quenching titration studies. Molecular docking studies further confirmed the proposed mechanism of enzymes’ inhibition. In silico predictions of physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of the selected most potent derivatives were performed using Swiss ADME tool. This was followed by UPLC-assisted log P determination and in vitro BBB permeability studies performed in order to assess the potential of the synthesized compounds to pass the BBB.",
journal = "International Journal of Molecular Sciences",
title = "Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates",
volume = "25",
number = "2",
pages = "1033",
doi = "10.3390/ijms25021033"
}

Jovanović, D., Filipović, A., Janjić, G., Lazarević-Pašti, T., Džambaski, Z., Bondžić, B.,& Bondžić, A.. (2024). Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates. in International Journal of Molecular Sciences, 25(2), 1033.
https://doi.org/10.3390/ijms25021033

Jovanović D, Filipović A, Janjić G, Lazarević-Pašti T, Džambaski Z, Bondžić B, Bondžić A. Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates. in International Journal of Molecular Sciences. 2024;25(2):1033.
doi:10.3390/ijms25021033 .

Jovanović, Dunja, Filipović, Ana, Janjić, Goran, Lazarević-Pašti, Tamara, Džambaski, Zdravko, Bondžić, Bojan, Bondžić, Aleksandra, "Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates" in International Journal of Molecular Sciences, 25, no. 2 (2024):1033,
https://doi.org/10.3390/ijms25021033 . .

TY  - CONF
AU  - Jovanović, Dunja
AU  - Filipović, Ana
AU  - Bondžić, Bojan
AU  - Bondžić, Aleksandra
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12228
AB  - Alzheimer's disease (AD), the most common form of dementia, is a progressive neurological disorder characterized by losing memory and other intellectual abilities that are serious enough to interfere with daily life. The disease is associated with loss of cholinergic neurons in the brain and the decreased level of ACh. In order to raise the ACh level in the brain the acetylcholinesterase (AChE) inhibitors have been applied as relevant drugs in the AD therapy. On the other hand, these inhibitors treat and improve only symptoms indicating necessity for new better therapies. One of them could be based on the inhibition of butyrylcholinesterase (BuChE) because of its increased activity during late stage of AD. Therefore, the BuChE inhibitors should be of great importance in therapy. 1,2,3,4-tetrahydroisoquinolines (THIQ) are a large group of natural and synthetic compounds which exert diverse biological activities against various infectious pathogens and neurodegenerative disorders. Due to these reasons, the THIQ have attracted a lot of attention in the scientific community which has resulted in the development of novel THIQ analogues with more potent biological activity. In this study the inhibitory potency of derivates of N-phenyl-1,2,3,4- tetrahydroisoquinoline, 178, 196 and 202, were investigated toward two cholinergic enzymes, AChE and BuChE. The performed screening tests pointed out the different inhibition potency of the selected compounds toward both enzymes which was related with their structures. The most potent compound has been 178 with IC50 values 1.30 μM and 2.50 μM toward AChE and BuChE, respectively. However, no selectivity was observed. Introducing F-atom in the para position of N-phenyl group of the compound 178, the compound 202 was obtained. In this way, the selectivity was increased towards acetylcholinesterase without significant influence on the IC50 value. However, introducing a methoxy groups in the position C3 and C4 of the tetrahydroisoquinoline’s ring of 202, the compound 196 with decreased inhibitory activity was obtained. IC50 value of 196 was one order of magnitude higher compared with compound 202. Based on the obtained results it is possible to conclude that introducing F atom in the para position of the phenyl ring lead to increased selectivity of the investigated compounds while introducing methoxy group in the position of C3 and C4 of tetrahydroisoquinoline ring leads to decrease of their inhibitory potency.
PB  - Niš : RAD Centre
C3  - RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
T1  - Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase
SP  - 134
EP  - 134
DO  - 10.21175/rad.abstr.book.2023.23.2
ER  - 

@conference{
author = "Jovanović, Dunja and Filipović, Ana and Bondžić, Bojan and Bondžić, Aleksandra",
year = "2023",
abstract = "Alzheimer's disease (AD), the most common form of dementia, is a progressive neurological disorder characterized by losing memory and other intellectual abilities that are serious enough to interfere with daily life. The disease is associated with loss of cholinergic neurons in the brain and the decreased level of ACh. In order to raise the ACh level in the brain the acetylcholinesterase (AChE) inhibitors have been applied as relevant drugs in the AD therapy. On the other hand, these inhibitors treat and improve only symptoms indicating necessity for new better therapies. One of them could be based on the inhibition of butyrylcholinesterase (BuChE) because of its increased activity during late stage of AD. Therefore, the BuChE inhibitors should be of great importance in therapy. 1,2,3,4-tetrahydroisoquinolines (THIQ) are a large group of natural and synthetic compounds which exert diverse biological activities against various infectious pathogens and neurodegenerative disorders. Due to these reasons, the THIQ have attracted a lot of attention in the scientific community which has resulted in the development of novel THIQ analogues with more potent biological activity. In this study the inhibitory potency of derivates of N-phenyl-1,2,3,4- tetrahydroisoquinoline, 178, 196 and 202, were investigated toward two cholinergic enzymes, AChE and BuChE. The performed screening tests pointed out the different inhibition potency of the selected compounds toward both enzymes which was related with their structures. The most potent compound has been 178 with IC50 values 1.30 μM and 2.50 μM toward AChE and BuChE, respectively. However, no selectivity was observed. Introducing F-atom in the para position of N-phenyl group of the compound 178, the compound 202 was obtained. In this way, the selectivity was increased towards acetylcholinesterase without significant influence on the IC50 value. However, introducing a methoxy groups in the position C3 and C4 of the tetrahydroisoquinoline’s ring of 202, the compound 196 with decreased inhibitory activity was obtained. IC50 value of 196 was one order of magnitude higher compared with compound 202. Based on the obtained results it is possible to conclude that introducing F atom in the para position of the phenyl ring lead to increased selectivity of the investigated compounds while introducing methoxy group in the position of C3 and C4 of tetrahydroisoquinoline ring leads to decrease of their inhibitory potency.",
publisher = "Niš : RAD Centre",
journal = "RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts",
title = "Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase",
pages = "134-134",
doi = "10.21175/rad.abstr.book.2023.23.2"
}

Jovanović, D., Filipović, A., Bondžić, B.,& Bondžić, A.. (2023). Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
Niš : RAD Centre., 134-134.
https://doi.org/10.21175/rad.abstr.book.2023.23.2

Jovanović D, Filipović A, Bondžić B, Bondžić A. Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts. 2023;:134-134.
doi:10.21175/rad.abstr.book.2023.23.2 .

Jovanović, Dunja, Filipović, Ana, Bondžić, Bojan, Bondžić, Aleksandra, "Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase" in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts (2023):134-134,
https://doi.org/10.21175/rad.abstr.book.2023.23.2 . .

TY  - JOUR
AU  - Filipović, Ana
AU  - Džambaski, Zdravko
AU  - Bondžić, Aleksandra M.
AU  - Bondžić, Bojan P.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11171
AB  - Visible light promoted photoredox catalyzed formation of α-amino radicals from cyclic tertiary amine compounds and their subsequent addition to Michael acceptors performed in flow conditions allowed access to a wide range of functionalized N-aryl-substituted tetrahydroisoquinolines (THIQs) and N-aryl-substituted tetrahydro-β-carbolines (THBCs). Visible light in conjunction with Ru(bpy)3Cl2 photocatalyst allowed the formation and high reactivities of α-amino radicals in flow conditions at room temperature. These reactions gave valuable products with high efficiencies; some previously unavailable reaction pathways photo or thermal reaction conditions; i.e. direct synthesis of 1-substituted (THBCs) via α-amino radical path were successfully realized in flow. The use of custom-made FEP tube microreactor proved to be the key to succesfull α-amino-radical formation and overall reaction performance in flow. Three types of light transparent custom-made microfluidic devices were tested, among them glass/silicon and FEP type reactor showed very good results in the conversion of tested compounds. Plausible reaction mechanism is proposed in accordance with known principles of photo activation of tertiary amines.
T2  - Photochemical & Photobiological Sciences
T1  - Visible-light promoted photoredox catalysis in flow: addition of biologically important α‑amino radicals to michael acceptors
DO  - 10.1007/s43630-023-00448-8
ER  - 

@article{
author = "Filipović, Ana and Džambaski, Zdravko and Bondžić, Aleksandra M. and Bondžić, Bojan P.",
year = "2023",
abstract = "Visible light promoted photoredox catalyzed formation of α-amino radicals from cyclic tertiary amine compounds and their subsequent addition to Michael acceptors performed in flow conditions allowed access to a wide range of functionalized N-aryl-substituted tetrahydroisoquinolines (THIQs) and N-aryl-substituted tetrahydro-β-carbolines (THBCs). Visible light in conjunction with Ru(bpy)3Cl2 photocatalyst allowed the formation and high reactivities of α-amino radicals in flow conditions at room temperature. These reactions gave valuable products with high efficiencies; some previously unavailable reaction pathways photo or thermal reaction conditions; i.e. direct synthesis of 1-substituted (THBCs) via α-amino radical path were successfully realized in flow. The use of custom-made FEP tube microreactor proved to be the key to succesfull α-amino-radical formation and overall reaction performance in flow. Three types of light transparent custom-made microfluidic devices were tested, among them glass/silicon and FEP type reactor showed very good results in the conversion of tested compounds. Plausible reaction mechanism is proposed in accordance with known principles of photo activation of tertiary amines.",
journal = "Photochemical & Photobiological Sciences",
title = "Visible-light promoted photoredox catalysis in flow: addition of biologically important α‑amino radicals to michael acceptors",
doi = "10.1007/s43630-023-00448-8"
}

Filipović, A., Džambaski, Z., Bondžić, A. M.,& Bondžić, B. P.. (2023). Visible-light promoted photoredox catalysis in flow: addition of biologically important α‑amino radicals to michael acceptors. in Photochemical & Photobiological Sciences.
https://doi.org/10.1007/s43630-023-00448-8

Filipović A, Džambaski Z, Bondžić AM, Bondžić BP. Visible-light promoted photoredox catalysis in flow: addition of biologically important α‑amino radicals to michael acceptors. in Photochemical & Photobiological Sciences. 2023;.
doi:10.1007/s43630-023-00448-8 .

Filipović, Ana, Džambaski, Zdravko, Bondžić, Aleksandra M., Bondžić, Bojan P., "Visible-light promoted photoredox catalysis in flow: addition of biologically important α‑amino radicals to michael acceptors" in Photochemical & Photobiological Sciences (2023),
https://doi.org/10.1007/s43630-023-00448-8 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Jovanović, Dunja
AU  - Arsenijević, Nevena
AU  - Laban, Bojana
AU  - Lazarević-Pašti, Tamara
AU  - Klekotka, Urszula
AU  - Bondžić, Bojan P.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10404
AB  - The study of the interactions between nanoparticles (NPs) and proteins has had a pivotal role in facilitating the understanding of biological effects and safe application of NPs after exposure to the physiological environment. Herein, for the first time, the interaction between L-methionine capped silver nanoparticles (AgMet), and bovine serum albumin (BSA) is investigated in order to predict the fate of AgMet after its contact with the most abundant blood transport protein. The detailed insights into the mechanism of interaction were achieved using different physicochemical techniques. The UV/Vis, TEM, and DLS were used for the characterization of the newly formed “entity”, while the kinetic and thermodynamic parameters were utilized to describe the adsorption process. Additionally, the fluorescence quenching and synchronous fluorescence studies enabled the prediction of the binding affinity and gave us insight into the influence of the adsorption on the conformation state of the BSA. According to the best of our knowledge, for the first time, we show that BSA can be used as an external stabilizer agent which is able to induce the peptization of previously agglomerated AgMet. We believe that the obtained results could contribute to further improvement of AgNPs’ performances as well as to the understanding of their in vivo behavior, which could contribute to their potential use in preclinical research studies.
T2  - International Journal of Molecular Sciences
T1  - “Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction
VL  - 23
IS  - 16
SP  - 8985
DO  - 10.3390/ijms23168985
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Jovanović, Dunja and Arsenijević, Nevena and Laban, Bojana and Lazarević-Pašti, Tamara and Klekotka, Urszula and Bondžić, Bojan P.",
year = "2022",
abstract = "The study of the interactions between nanoparticles (NPs) and proteins has had a pivotal role in facilitating the understanding of biological effects and safe application of NPs after exposure to the physiological environment. Herein, for the first time, the interaction between L-methionine capped silver nanoparticles (AgMet), and bovine serum albumin (BSA) is investigated in order to predict the fate of AgMet after its contact with the most abundant blood transport protein. The detailed insights into the mechanism of interaction were achieved using different physicochemical techniques. The UV/Vis, TEM, and DLS were used for the characterization of the newly formed “entity”, while the kinetic and thermodynamic parameters were utilized to describe the adsorption process. Additionally, the fluorescence quenching and synchronous fluorescence studies enabled the prediction of the binding affinity and gave us insight into the influence of the adsorption on the conformation state of the BSA. According to the best of our knowledge, for the first time, we show that BSA can be used as an external stabilizer agent which is able to induce the peptization of previously agglomerated AgMet. We believe that the obtained results could contribute to further improvement of AgNPs’ performances as well as to the understanding of their in vivo behavior, which could contribute to their potential use in preclinical research studies.",
journal = "International Journal of Molecular Sciences",
title = "“Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction",
volume = "23",
number = "16",
pages = "8985",
doi = "10.3390/ijms23168985"
}

Bondžić, A. M., Jovanović, D., Arsenijević, N., Laban, B., Lazarević-Pašti, T., Klekotka, U.,& Bondžić, B. P.. (2022). “Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction. in International Journal of Molecular Sciences, 23(16), 8985.
https://doi.org/10.3390/ijms23168985

Bondžić AM, Jovanović D, Arsenijević N, Laban B, Lazarević-Pašti T, Klekotka U, Bondžić BP. “Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction. in International Journal of Molecular Sciences. 2022;23(16):8985.
doi:10.3390/ijms23168985 .

Bondžić, Aleksandra M., Jovanović, Dunja, Arsenijević, Nevena, Laban, Bojana, Lazarević-Pašti, Tamara, Klekotka, Urszula, Bondžić, Bojan P., "“Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction" in International Journal of Molecular Sciences, 23, no. 16 (2022):8985,
https://doi.org/10.3390/ijms23168985 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Lazarević-Pašti, Tamara
AU  - Pašti, Igor A.
AU  - Bondžić, Bojan P.
AU  - Momčilović, Miloš
AU  - Loosen, Alexandra
AU  - Parac-Vogt, Tatjana N.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10210
AB  - Organophosphate-based pesticides have remarkably contributed to the agriculture industry, but their toxicity has a large negative impact on the environment as well as on the health of humans and other living organisms. Most of the methods developed to remedy the organophosphate pesticide toxicity are very time-consuming and are based on their adsorption onto different materials and/or their degradation to nontoxic species. In this study, detoxification of three structurally different organophosphate pesticides was investigated using an NU-1000 metal–organic framework. We showed that NU-1000 is an excellent agent for fast (average time ≤ 3 min) and effective removal of organophosphate pesticides with an aromatic heterocyclic moiety. In particular, superior detoxification of chlorpyrifos solution after NU-1000 treatment was achieved after only 1 min. The combination of experimental and computational methods revealed that the synergic effects of sorption and hydrolysis are responsible for the superior removal of CHP by NU-1000. The sorption process occurs on the Zr node (chemisorption) and pyrene linkers (physisorption) following pseudo-first-order kinetics during the first minute, and a pseudo-second-order model fits the entire time range. The multilayer adsorption of chlorpyrifos or its hydrolyzed product, 3,5,6-trichloro-2-pyridinol, takes place on a pyrene linker, whereas the aliphatic part of the molecule remains chemisorbed on the Zr node. Such unique synergy between induced sorption and hydrolysis of chlorpyrifos by NU-1000 results in its fast and effective removal with rapid detoxification in non-buffered solutions.
T2  - ACS Applied Nano Materials
T1  - Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos
VL  - 5
IS  - 3
SP  - 3312
EP  - 3324
DO  - 10.1021/acsanm.1c03863
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Lazarević-Pašti, Tamara and Pašti, Igor A. and Bondžić, Bojan P. and Momčilović, Miloš and Loosen, Alexandra and Parac-Vogt, Tatjana N.",
year = "2022",
abstract = "Organophosphate-based pesticides have remarkably contributed to the agriculture industry, but their toxicity has a large negative impact on the environment as well as on the health of humans and other living organisms. Most of the methods developed to remedy the organophosphate pesticide toxicity are very time-consuming and are based on their adsorption onto different materials and/or their degradation to nontoxic species. In this study, detoxification of three structurally different organophosphate pesticides was investigated using an NU-1000 metal–organic framework. We showed that NU-1000 is an excellent agent for fast (average time ≤ 3 min) and effective removal of organophosphate pesticides with an aromatic heterocyclic moiety. In particular, superior detoxification of chlorpyrifos solution after NU-1000 treatment was achieved after only 1 min. The combination of experimental and computational methods revealed that the synergic effects of sorption and hydrolysis are responsible for the superior removal of CHP by NU-1000. The sorption process occurs on the Zr node (chemisorption) and pyrene linkers (physisorption) following pseudo-first-order kinetics during the first minute, and a pseudo-second-order model fits the entire time range. The multilayer adsorption of chlorpyrifos or its hydrolyzed product, 3,5,6-trichloro-2-pyridinol, takes place on a pyrene linker, whereas the aliphatic part of the molecule remains chemisorbed on the Zr node. Such unique synergy between induced sorption and hydrolysis of chlorpyrifos by NU-1000 results in its fast and effective removal with rapid detoxification in non-buffered solutions.",
journal = "ACS Applied Nano Materials",
title = "Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos",
volume = "5",
number = "3",
pages = "3312-3324",
doi = "10.1021/acsanm.1c03863"
}

Bondžić, A. M., Lazarević-Pašti, T., Pašti, I. A., Bondžić, B. P., Momčilović, M., Loosen, A.,& Parac-Vogt, T. N.. (2022). Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos. in ACS Applied Nano Materials, 5(3), 3312-3324.
https://doi.org/10.1021/acsanm.1c03863

Bondžić AM, Lazarević-Pašti T, Pašti IA, Bondžić BP, Momčilović M, Loosen A, Parac-Vogt TN. Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos. in ACS Applied Nano Materials. 2022;5(3):3312-3324.
doi:10.1021/acsanm.1c03863 .

Bondžić, Aleksandra M., Lazarević-Pašti, Tamara, Pašti, Igor A., Bondžić, Bojan P., Momčilović, Miloš, Loosen, Alexandra, Parac-Vogt, Tatjana N., "Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos" in ACS Applied Nano Materials, 5, no. 3 (2022):3312-3324,
https://doi.org/10.1021/acsanm.1c03863 . .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Jovanović, Dunja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12681
AB  - The main goal of this work was the elucidation of the binding interactions between bovine serum
albumin (BSA) and methionine coated silver nanoparticles (AgNPs) under physiological like
conditions using fluorescence spectroscopy techniques. The quenching of BSA’s tryptophan
fluorescence has occurred at the concentration-dependent manner. The linear shape obtained for
Stern-Volmer plots and its larger slope at higher temperatures indicated mixed static and dynamic
quenching mechanisms. The values of quenching constants, Ksv and the bimolecular quenching rate
constants, kq, pointed out the existence of binding interactions between BSA and AgNPs. The
binding constants, K, with values around 1 × 104
 M-1, indicated low to moderate binding interaction
with one binding site. Determined thermodynamic parameters ΔHo < 0, ΔSo < 0 and ΔGo
 < 0 at different temperatures pointed out spontaneous processes, where hydrogen and van der Waals
interactions play a major role in the binding.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
T1  - Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction
VL  - 2
SP  - 609
EP  - 612
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12681
ER  - 

@conference{
author = "Bondžić, Aleksandra and Jovanović, Dunja",
year = "2022",
abstract = "The main goal of this work was the elucidation of the binding interactions between bovine serum
albumin (BSA) and methionine coated silver nanoparticles (AgNPs) under physiological like
conditions using fluorescence spectroscopy techniques. The quenching of BSA’s tryptophan
fluorescence has occurred at the concentration-dependent manner. The linear shape obtained for
Stern-Volmer plots and its larger slope at higher temperatures indicated mixed static and dynamic
quenching mechanisms. The values of quenching constants, Ksv and the bimolecular quenching rate
constants, kq, pointed out the existence of binding interactions between BSA and AgNPs. The
binding constants, K, with values around 1 × 104
 M-1, indicated low to moderate binding interaction
with one binding site. Determined thermodynamic parameters ΔHo < 0, ΔSo < 0 and ΔGo
 < 0 at different temperatures pointed out spontaneous processes, where hydrogen and van der Waals
interactions play a major role in the binding.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings",
title = "Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction",
volume = "2",
pages = "609-612",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12681"
}

Bondžić, A.,& Jovanović, D.. (2022). Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 2, 609-612.
https://hdl.handle.net/21.15107/rcub_vinar_12681

Bondžić A, Jovanović D. Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings. 2022;2:609-612.
https://hdl.handle.net/21.15107/rcub_vinar_12681 .

Bondžić, Aleksandra, Jovanović, Dunja, "Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings, 2 (2022):609-612,
https://hdl.handle.net/21.15107/rcub_vinar_12681 .

TY  - JOUR
AU  - Relić, Renata
AU  - Škrbi̇ć, Zdenka
AU  - Boži̇čkovi̇ć, Ivana
AU  - Luki̇ć, Miloš
AU  - Petri̇čevi̇ć, Veselin
AU  - Deli̇ć, Nikola
AU  - Bondžić, Aleksandra M.
AU  - Vi̇torovi̇ć, Duško
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10540
AB  - Intensive broiler chicken production involves different lighting regimes, which affects a natural cycle of secretion of melatonin, a hormone included in multiple physiological processes in a bird's body. This research aimed to determine the effects of dietary melatonin supplementation during the first two weeks of broiler chickens' life, bred under constant 24 h lighting, on their health and some hematological, biochemical, and production parameters. The study lasted 6 weeks. Three hundred and twenty 1-day chickens were divided into two groups (control - C and experimental - M), with four replications and 40 chickens in each replica. In the first two weeks (the first phase of the study), a continuous lighting mode 24L: 0D was applied. Group M was receiving a diet supplemented with 30 mg/kg synthetic melatonin only during the first phase. Group C had a diet without melatonin supplementation throughout the whole study. Melatonin addition had a statistically significant effect (P<0.01) on the mean values of body weight and daily weight gain at the end of the 1st, 2nd, 3rd, 4th, 5th, and 6th week. The chickens of the experimental group have had a significantly higher value of the European Production Efficiency Factor (EPEF) (P<0.05). The results presented in this paper indicate a direct benefit in stress relief in broilers and a value of the organism's antioxidant system promotion, manifested by improved production performance and fattening efficiency.
T2  - Ankara Üniversitesi Veteriner Fakültesi Dergisi
T1  - Effects of dietary melatonin on broiler chicken exposed to continuous lighting during the first two weeks of life
VL  - 69
IS  - 4
SP  - 361
EP  - 366
DO  - 10.33988/auvfd.866702
ER  - 

@article{
author = "Relić, Renata and Škrbi̇ć, Zdenka and Boži̇čkovi̇ć, Ivana and Luki̇ć, Miloš and Petri̇čevi̇ć, Veselin and Deli̇ć, Nikola and Bondžić, Aleksandra M. and Vi̇torovi̇ć, Duško",
year = "2022",
abstract = "Intensive broiler chicken production involves different lighting regimes, which affects a natural cycle of secretion of melatonin, a hormone included in multiple physiological processes in a bird's body. This research aimed to determine the effects of dietary melatonin supplementation during the first two weeks of broiler chickens' life, bred under constant 24 h lighting, on their health and some hematological, biochemical, and production parameters. The study lasted 6 weeks. Three hundred and twenty 1-day chickens were divided into two groups (control - C and experimental - M), with four replications and 40 chickens in each replica. In the first two weeks (the first phase of the study), a continuous lighting mode 24L: 0D was applied. Group M was receiving a diet supplemented with 30 mg/kg synthetic melatonin only during the first phase. Group C had a diet without melatonin supplementation throughout the whole study. Melatonin addition had a statistically significant effect (P<0.01) on the mean values of body weight and daily weight gain at the end of the 1st, 2nd, 3rd, 4th, 5th, and 6th week. The chickens of the experimental group have had a significantly higher value of the European Production Efficiency Factor (EPEF) (P<0.05). The results presented in this paper indicate a direct benefit in stress relief in broilers and a value of the organism's antioxidant system promotion, manifested by improved production performance and fattening efficiency.",
journal = "Ankara Üniversitesi Veteriner Fakültesi Dergisi",
title = "Effects of dietary melatonin on broiler chicken exposed to continuous lighting during the first two weeks of life",
volume = "69",
number = "4",
pages = "361-366",
doi = "10.33988/auvfd.866702"
}

Relić, R., Škrbi̇ć, Z., Boži̇čkovi̇ć, I., Luki̇ć, M., Petri̇čevi̇ć, V., Deli̇ć, N., Bondžić, A. M.,& Vi̇torovi̇ć, D.. (2022). Effects of dietary melatonin on broiler chicken exposed to continuous lighting during the first two weeks of life. in Ankara Üniversitesi Veteriner Fakültesi Dergisi, 69(4), 361-366.
https://doi.org/10.33988/auvfd.866702

Relić R, Škrbi̇ć Z, Boži̇čkovi̇ć I, Luki̇ć M, Petri̇čevi̇ć V, Deli̇ć N, Bondžić AM, Vi̇torovi̇ć D. Effects of dietary melatonin on broiler chicken exposed to continuous lighting during the first two weeks of life. in Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022;69(4):361-366.
doi:10.33988/auvfd.866702 .

Relić, Renata, Škrbi̇ć, Zdenka, Boži̇čkovi̇ć, Ivana, Luki̇ć, Miloš, Petri̇čevi̇ć, Veselin, Deli̇ć, Nikola, Bondžić, Aleksandra M., Vi̇torovi̇ć, Duško, "Effects of dietary melatonin on broiler chicken exposed to continuous lighting during the first two weeks of life" in Ankara Üniversitesi Veteriner Fakültesi Dergisi, 69, no. 4 (2022):361-366,
https://doi.org/10.33988/auvfd.866702 . .

TY  - CHAP
AU  - Bondžić, Aleksandra
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10727
AB  - Organophosphate compounds (OPs) are highly acute toxic compounds used in agriculture production as pesticides. They bind to acetylcholinesterase leading to nerve paralysis and organ failure in humans. Hence, it has become mandatory on a global level to detect and remove organophosphate compounds from the environment. There are many conventional methods (nanoscale materials or sophisticated instruments) available to detect these compounds. However, these methods are time-consuming, expensive, and require an analytical laboratory with skilled staff. These constraints were the driving force for developing sensing platforms capable of detecting pesticides with excellent sensitivity. Metal-organic frameworks (MOFs) belong to porous coordination polymers fabricated from metal clusters/ions and multifunctional organic ligands. The tunable size and shape of pores, stable framework and the opportunity for desirable post-synthetic modifications classify them as promising candidates for potential use in detecting OPs at low nanomolar levels. This chapter will discuss the application of MOFs for the detection of selected organophosphate compounds. The special emphasis will be on MOF-based sensors, their sensitivity, selectivity, advantages and disadvantages in the OPs detection process. © 2022 Nova Science Publishers, Inc.
T2  - Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment
T1  - MOFs Compounds as Effective Tools for Detection of Organophosphate Compounds
SP  - 291
EP  - 314
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10727
ER  - 

@inbook{
author = "Bondžić, Aleksandra",
year = "2022",
abstract = "Organophosphate compounds (OPs) are highly acute toxic compounds used in agriculture production as pesticides. They bind to acetylcholinesterase leading to nerve paralysis and organ failure in humans. Hence, it has become mandatory on a global level to detect and remove organophosphate compounds from the environment. There are many conventional methods (nanoscale materials or sophisticated instruments) available to detect these compounds. However, these methods are time-consuming, expensive, and require an analytical laboratory with skilled staff. These constraints were the driving force for developing sensing platforms capable of detecting pesticides with excellent sensitivity. Metal-organic frameworks (MOFs) belong to porous coordination polymers fabricated from metal clusters/ions and multifunctional organic ligands. The tunable size and shape of pores, stable framework and the opportunity for desirable post-synthetic modifications classify them as promising candidates for potential use in detecting OPs at low nanomolar levels. This chapter will discuss the application of MOFs for the detection of selected organophosphate compounds. The special emphasis will be on MOF-based sensors, their sensitivity, selectivity, advantages and disadvantages in the OPs detection process. © 2022 Nova Science Publishers, Inc.",
journal = "Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment",
booktitle = "MOFs Compounds as Effective Tools for Detection of Organophosphate Compounds",
pages = "291-314",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10727"
}

Bondžić, A.. (2022). MOFs Compounds as Effective Tools for Detection of Organophosphate Compounds. in Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment, 291-314.
https://hdl.handle.net/21.15107/rcub_vinar_10727

Bondžić A. MOFs Compounds as Effective Tools for Detection of Organophosphate Compounds. in Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment. 2022;:291-314.
https://hdl.handle.net/21.15107/rcub_vinar_10727 .

Bondžić, Aleksandra, "MOFs Compounds as Effective Tools for Detection of Organophosphate Compounds" in Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment (2022):291-314,
https://hdl.handle.net/21.15107/rcub_vinar_10727 .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Jovanović, Dunja
AU  - Džambaski, Zdravko
AU  - Filipović, Ana
AU  - Bondžić, Bojan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12366
AB  - The goal of this work was to investigate the inhibitory potency of three derivates of 2- phenyl-1,2,3,4-tetrahydroisoquinoline (THIQ) with different substituents at C3 and C4 positions, namely 65P,71P and 66P, toward two cholinergic enzymes, acetyl and butyrylcholinesterase. The screening test showed that only compound 65P possesses inhibition activity higher than 50 % at 10 μM concentration toward both enzymes. The inhibition potency obtained at 10 μM of THIQ was correlated with differences in THIQ’s structures in order to predict the structure-activity relationship. It was found that the introduction of the methoxy group at positions C3 and C4 led to decreased inhibition potency, while the removing of fluorine atom from the benzene ring increases selectivity toward acetylcholinesterase. The IC50 value gained during the evaluation of inhibition activity of 65P indicated strong inhibition potency of this compound, while Hill’s coefficient ~ 1 indicated the non-existence of cooperativity and one binding site on both enzymes clearly indicating that THIQ could be promising therapeutic drugs in the treatment of Alzheimer’s disease.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
T1  - New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes
SP  - 170
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12366
ER  - 

@conference{
author = "Bondžić, Aleksandra and Jovanović, Dunja and Džambaski, Zdravko and Filipović, Ana and Bondžić, Bojan",
year = "2022",
abstract = "The goal of this work was to investigate the inhibitory potency of three derivates of 2- phenyl-1,2,3,4-tetrahydroisoquinoline (THIQ) with different substituents at C3 and C4 positions, namely 65P,71P and 66P, toward two cholinergic enzymes, acetyl and butyrylcholinesterase. The screening test showed that only compound 65P possesses inhibition activity higher than 50 % at 10 μM concentration toward both enzymes. The inhibition potency obtained at 10 μM of THIQ was correlated with differences in THIQ’s structures in order to predict the structure-activity relationship. It was found that the introduction of the methoxy group at positions C3 and C4 led to decreased inhibition potency, while the removing of fluorine atom from the benzene ring increases selectivity toward acetylcholinesterase. The IC50 value gained during the evaluation of inhibition activity of 65P indicated strong inhibition potency of this compound, while Hill’s coefficient ~ 1 indicated the non-existence of cooperativity and one binding site on both enzymes clearly indicating that THIQ could be promising therapeutic drugs in the treatment of Alzheimer’s disease.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts",
title = "New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes",
pages = "170-170",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12366"
}

Bondžić, A., Jovanović, D., Džambaski, Z., Filipović, A.,& Bondžić, B.. (2022). New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
Belgrade : Society of Physical Chemists of Serbia., 170-170.
https://hdl.handle.net/21.15107/rcub_vinar_12366

Bondžić A, Jovanović D, Džambaski Z, Filipović A, Bondžić B. New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts. 2022;:170-170.
https://hdl.handle.net/21.15107/rcub_vinar_12366 .

Bondžić, Aleksandra, Jovanović, Dunja, Džambaski, Zdravko, Filipović, Ana, Bondžić, Bojan, "New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts (2022):170-170,
https://hdl.handle.net/21.15107/rcub_vinar_12366 .

TY  - JOUR
AU  - Džambaski, Zdravko
AU  - Bondžić, Aleksandra M.
AU  - Triandafillidi, Ierasia
AU  - Kokotos, Christoforos G.
AU  - Bondžić, Bojan P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9871
AB  - Herein, we demonstrate that organic, single-electron oxidant in the presence of diarylprolinol silylether type catalyst serves as a tool for the transformation of electron-rich enamines to iminium ions. These iminium ions take part in a subsequent Michael-initiated ring-closure (MIRC) reaction with in situ present nucleophile giving rise to overall cyclopropanation reaction of saturated aldehydes. Stereodefined cyclopropanes are obtained in high yields and selectivities. This one-pot transformation represents the additional example of saturated aldehydes being used in the coupled one-pot processes. (Figure presented.).
T2  - Advanced Synthesis and Catalysis
T1  - Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction
VL  - 363
IS  - 16
SP  - 4002
EP  - 4008
DO  - 10.1002/adsc.202100630
ER  - 

@article{
author = "Džambaski, Zdravko and Bondžić, Aleksandra M. and Triandafillidi, Ierasia and Kokotos, Christoforos G. and Bondžić, Bojan P.",
year = "2021",
abstract = "Herein, we demonstrate that organic, single-electron oxidant in the presence of diarylprolinol silylether type catalyst serves as a tool for the transformation of electron-rich enamines to iminium ions. These iminium ions take part in a subsequent Michael-initiated ring-closure (MIRC) reaction with in situ present nucleophile giving rise to overall cyclopropanation reaction of saturated aldehydes. Stereodefined cyclopropanes are obtained in high yields and selectivities. This one-pot transformation represents the additional example of saturated aldehydes being used in the coupled one-pot processes. (Figure presented.).",
journal = "Advanced Synthesis and Catalysis",
title = "Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction",
volume = "363",
number = "16",
pages = "4002-4008",
doi = "10.1002/adsc.202100630"
}

Džambaski, Z., Bondžić, A. M., Triandafillidi, I., Kokotos, C. G.,& Bondžić, B. P.. (2021). Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction. in Advanced Synthesis and Catalysis, 363(16), 4002-4008.
https://doi.org/10.1002/adsc.202100630

Džambaski Z, Bondžić AM, Triandafillidi I, Kokotos CG, Bondžić BP. Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction. in Advanced Synthesis and Catalysis. 2021;363(16):4002-4008.
doi:10.1002/adsc.202100630 .

Džambaski, Zdravko, Bondžić, Aleksandra M., Triandafillidi, Ierasia, Kokotos, Christoforos G., Bondžić, Bojan P., "Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction" in Advanced Synthesis and Catalysis, 363, no. 16 (2021):4002-4008,
https://doi.org/10.1002/adsc.202100630 . .

TY  - CONF
AU  - Leskovac, Andreja
AU  - Čolović, Mirjana
AU  - Bondžić, Aleksandra
AU  - Petrović, Sandra
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11686
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
T1  - N-Acetylcysteine as Regulator of the Cellular Homeostasis
SP  - 192
EP  - 195
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11686
ER  - 

@conference{
author = "Leskovac, Andreja and Čolović, Mirjana and Bondžić, Aleksandra and Petrović, Sandra",
year = "2021",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry",
title = "N-Acetylcysteine as Regulator of the Cellular Homeostasis",
pages = "192-195",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11686"
}

Leskovac, A., Čolović, M., Bondžić, A.,& Petrović, S.. (2021). N-Acetylcysteine as Regulator of the Cellular Homeostasis. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
Belgrade : Vinča Institute of Nuclear Sciences., 192-195.
https://hdl.handle.net/21.15107/rcub_vinar_11686

Leskovac A, Čolović M, Bondžić A, Petrović S. N-Acetylcysteine as Regulator of the Cellular Homeostasis. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry. 2021;:192-195.
https://hdl.handle.net/21.15107/rcub_vinar_11686 .

Leskovac, Andreja, Čolović, Mirjana, Bondžić, Aleksandra, Petrović, Sandra, "N-Acetylcysteine as Regulator of the Cellular Homeostasis" in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry (2021):192-195,
https://hdl.handle.net/21.15107/rcub_vinar_11686 .

TY  - CONF
AU  - Petrović, Sandra
AU  - Bondžić, Aleksandra
AU  - Nastasijević, Branislav
AU  - Leskovac, Andreja
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11687
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
T1  - Genotoxicity Testing of Acacia Honeys of Different Geographical Origin
SP  - 127
EP  - 130
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11687
ER  - 

@conference{
author = "Petrović, Sandra and Bondžić, Aleksandra and Nastasijević, Branislav and Leskovac, Andreja",
year = "2021",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry",
title = "Genotoxicity Testing of Acacia Honeys of Different Geographical Origin",
pages = "127-130",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11687"
}

Petrović, S., Bondžić, A., Nastasijević, B.,& Leskovac, A.. (2021). Genotoxicity Testing of Acacia Honeys of Different Geographical Origin. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
Belgrade : Vinča Institute of Nuclear Sciences., 127-130.
https://hdl.handle.net/21.15107/rcub_vinar_11687

Petrović S, Bondžić A, Nastasijević B, Leskovac A. Genotoxicity Testing of Acacia Honeys of Different Geographical Origin. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry. 2021;:127-130.
https://hdl.handle.net/21.15107/rcub_vinar_11687 .

Petrović, Sandra, Bondžić, Aleksandra, Nastasijević, Branislav, Leskovac, Andreja, "Genotoxicity Testing of Acacia Honeys of Different Geographical Origin" in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry (2021):127-130,
https://hdl.handle.net/21.15107/rcub_vinar_11687 .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Žakula, Jelena
AU  - Korićanac, Lela B.
AU  - Keta, Otilija D.
AU  - Janjić, Goran V.
AU  - Đorđević, Ivana S.
AU  - Rajković, Snežana U.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10015
AB  - Herein, the stability, lipophilicity, in vitro cytotoxicity, and influence on acetylcholinesterase of five dinuclear platinum(II) complexes with the general formula [{Pt(en)Cl}2(μ-L)]2+ (L is a different aromatic nitrogen-containing heterocyclic bridging ligands pyrazine (pz, Pt1), pyridazine (pydz, Pt2), quinoxaline (qx, Pt3), phthalazine (phtz, Pt4) and quinazoline (qz, Pt5), while en is bidentate coordinated ethylenediamine) were evaluated. The most active analyzed platinum complexes induced time-dependent growth inhibition of A375, HeLa, PANC-1, and MRC-5 cells. The best efficiency was achieved on HeLa and PANC-1 cells for Pt1, Pt2, and Pt3 at the highest concentration, while Pt1 was significantly more potent than cisplatin at a lower concentration. Additionally, a lower effect on normal cells was observed compared to cisplatin, which may indicate potentially fewer side effects of these complexes. Selected complexes induce reactive oxygen species and apoptosis on tumor cell lines. The most potent reversible acetylcholinesterase (AChE) inhibitors were Pt2, Pt4, and Pt5. Pt1 showed similar inhibitory potential toward AChE as cisplatin, but a different type of inhibition, which could contribute to lower neurotoxicity. Docking studies revealed that Pt2 and Pt4 were bound to the active gorge above the catalytic triad. In contrast, the other complexes were bound to the edge of the active gorge without impeding the approach to the catalytic triad. According to this, Pt1 represents a promising compound with potent anticancer properties, high selectivity, and low neurotoxicity.
T2  - Chemico-Biological Interactions
T1  - Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action
SP  - 109708
DO  - 10.1016/j.cbi.2021.109708
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Žakula, Jelena and Korićanac, Lela B. and Keta, Otilija D. and Janjić, Goran V. and Đorđević, Ivana S. and Rajković, Snežana U.",
year = "2021",
abstract = "Herein, the stability, lipophilicity, in vitro cytotoxicity, and influence on acetylcholinesterase of five dinuclear platinum(II) complexes with the general formula [{Pt(en)Cl}2(μ-L)]2+ (L is a different aromatic nitrogen-containing heterocyclic bridging ligands pyrazine (pz, Pt1), pyridazine (pydz, Pt2), quinoxaline (qx, Pt3), phthalazine (phtz, Pt4) and quinazoline (qz, Pt5), while en is bidentate coordinated ethylenediamine) were evaluated. The most active analyzed platinum complexes induced time-dependent growth inhibition of A375, HeLa, PANC-1, and MRC-5 cells. The best efficiency was achieved on HeLa and PANC-1 cells for Pt1, Pt2, and Pt3 at the highest concentration, while Pt1 was significantly more potent than cisplatin at a lower concentration. Additionally, a lower effect on normal cells was observed compared to cisplatin, which may indicate potentially fewer side effects of these complexes. Selected complexes induce reactive oxygen species and apoptosis on tumor cell lines. The most potent reversible acetylcholinesterase (AChE) inhibitors were Pt2, Pt4, and Pt5. Pt1 showed similar inhibitory potential toward AChE as cisplatin, but a different type of inhibition, which could contribute to lower neurotoxicity. Docking studies revealed that Pt2 and Pt4 were bound to the active gorge above the catalytic triad. In contrast, the other complexes were bound to the edge of the active gorge without impeding the approach to the catalytic triad. According to this, Pt1 represents a promising compound with potent anticancer properties, high selectivity, and low neurotoxicity.",
journal = "Chemico-Biological Interactions",
title = "Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action",
pages = "109708",
doi = "10.1016/j.cbi.2021.109708"
}

Bondžić, A. M., Žakula, J., Korićanac, L. B., Keta, O. D., Janjić, G. V., Đorđević, I. S.,& Rajković, S. U.. (2021). Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action. in Chemico-Biological Interactions, 109708.
https://doi.org/10.1016/j.cbi.2021.109708

Bondžić AM, Žakula J, Korićanac LB, Keta OD, Janjić GV, Đorđević IS, Rajković SU. Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action. in Chemico-Biological Interactions. 2021;:109708.
doi:10.1016/j.cbi.2021.109708 .

Bondžić, Aleksandra M., Žakula, Jelena, Korićanac, Lela B., Keta, Otilija D., Janjić, Goran V., Đorđević, Ivana S., Rajković, Snežana U., "Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action" in Chemico-Biological Interactions (2021):109708,
https://doi.org/10.1016/j.cbi.2021.109708 . .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Jovanović, Dunja
AU  - Leskovac, Andreja
AU  - Džambaski, Zdravko
AU  - Bondžić, Bojan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11683
AB  - In this study, the kinetics of bovine serum albumin (BSA) adsorption from aqueous solutions on the
methionine stabilized silver nanoparticles (AgNPs) was investigated. The influence of the parameters
such as contact time and BSA initial concentration on the adsorption capacity of AgNPs were tested.
By increasing the contact time up to 30 min, the percentage of adsorbed BSA was increased. After
this time, no changes were observed, indicating that the equilibrium state was reached. Investigation
of the initial concentration-effect showed that the percentage of BSA adsorption increased with
increasing BSA concentration until the available binding sites were saturated. After that, more BSA
molecules were left unadsorbed. To elucidate the adsorption kinetic, pseudo-first-order, pseudosecond-order, and intraparticle diffusion kinetic models were applied. The pseudo-second-order well
described the adsorption process and intraparticle diffusion model rate laws, and the intraparticle
diffusion is the sole rate-controlling step.
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
T1  - Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles
SP  - 332
EP  - 335
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11683
ER  - 

@conference{
author = "Bondžić, Aleksandra and Jovanović, Dunja and Leskovac, Andreja and Džambaski, Zdravko and Bondžić, Bojan",
year = "2021",
abstract = "In this study, the kinetics of bovine serum albumin (BSA) adsorption from aqueous solutions on the
methionine stabilized silver nanoparticles (AgNPs) was investigated. The influence of the parameters
such as contact time and BSA initial concentration on the adsorption capacity of AgNPs were tested.
By increasing the contact time up to 30 min, the percentage of adsorbed BSA was increased. After
this time, no changes were observed, indicating that the equilibrium state was reached. Investigation
of the initial concentration-effect showed that the percentage of BSA adsorption increased with
increasing BSA concentration until the available binding sites were saturated. After that, more BSA
molecules were left unadsorbed. To elucidate the adsorption kinetic, pseudo-first-order, pseudosecond-order, and intraparticle diffusion kinetic models were applied. The pseudo-second-order well
described the adsorption process and intraparticle diffusion model rate laws, and the intraparticle
diffusion is the sole rate-controlling step.",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24",
title = "Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles",
pages = "332-335",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11683"
}

Bondžić, A., Jovanović, D., Leskovac, A., Džambaski, Z.,& Bondžić, B.. (2021). Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
The Society of Physical Chemists of Serbia., 332-335.
https://hdl.handle.net/21.15107/rcub_vinar_11683

Bondžić A, Jovanović D, Leskovac A, Džambaski Z, Bondžić B. Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24. 2021;:332-335.
https://hdl.handle.net/21.15107/rcub_vinar_11683 .

Bondžić, Aleksandra, Jovanović, Dunja, Leskovac, Andreja, Džambaski, Zdravko, Bondžić, Bojan, "Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24 (2021):332-335,
https://hdl.handle.net/21.15107/rcub_vinar_11683 .

TY  - JOUR
AU  - Vujačić Nikezić, Ana V.
AU  - Bondžić, Aleksandra M.
AU  - Vasić, Vesna M.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9049
AB  - A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.
T2  - European Journal of Pharmaceutical Sciences
T1  - Drug delivery systems based on nanoparticles and related nanostructures
VL  - 151
SP  - 105412
DO  - 10.1016/j.ejps.2020.105412
ER  - 

@article{
author = "Vujačić Nikezić, Ana V. and Bondžić, Aleksandra M. and Vasić, Vesna M.",
year = "2020",
abstract = "A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Drug delivery systems based on nanoparticles and related nanostructures",
volume = "151",
pages = "105412",
doi = "10.1016/j.ejps.2020.105412"
}

Vujačić Nikezić, A. V., Bondžić, A. M.,& Vasić, V. M.. (2020). Drug delivery systems based on nanoparticles and related nanostructures. in European Journal of Pharmaceutical Sciences, 151, 105412.
https://doi.org/10.1016/j.ejps.2020.105412

Vujačić Nikezić AV, Bondžić AM, Vasić VM. Drug delivery systems based on nanoparticles and related nanostructures. in European Journal of Pharmaceutical Sciences. 2020;151:105412.
doi:10.1016/j.ejps.2020.105412 .

Vujačić Nikezić, Ana V., Bondžić, Aleksandra M., Vasić, Vesna M., "Drug delivery systems based on nanoparticles and related nanostructures" in European Journal of Pharmaceutical Sciences, 151 (2020):105412,
https://doi.org/10.1016/j.ejps.2020.105412 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Senćanski, Milan V.
AU  - Vujačić Nikezić, Ana V.
AU  - Kirillova, Marina V.
AU  - André, Vania
AU  - Kirillov, Alexander M.
AU  - Bondžić, Bojan P.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8806
AB  - Three coordination compounds featuring different types of tetracopper(II) cores, namely [O ⊂ Cu4N(CH2CH2O)34(BOH)4][BF4]2 (1), [Cu4(μ4-H2edte)(μ5-H2edte)(sal)2]n·7nH2O, (H4edte = N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine, H2sal = salicylic acid) (2), and [Cu4(μ3-Hbes)4(μ-hba)K(H2O)3]n, H3bes = N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (3), were assayed for their potency to inhibit the acetyl (AChE) and butyrylcholinesterase (BuChE) enzymes aiming to test these compounds as potential dual inhibitors in the treatment of Alzheimer's disease. All the investigated compounds showed a strong inhibitory potency toward both enzymes with IC50 values in micromolar range of concentration; compound 1 displayed the most potent inhibitory behaviour toward both enzymes. The mechanism of the AChE and BuChE inhibition was examined by enzyme kinetic measurements. The obtained kinetic parameters, Vmax and Km indicated an uncompetitive type of inhibition of both enzymes by compound 1. For the other two compounds a non-competitive inhibition mode was observed. To get further insight into the mechanism of action and to elucidate binding modes in details we examined the interactions of 1–3 with acetylcholinesterase, using molecular docking approach. Grid based docking studies indicated that these compounds can bind to peripheral anionic site (PAS) of the AChE with Ki values in micromolar range. Moreover, blind docking revealed the capability of investigated compounds to bind to new allosteric site (i.e. binding site II) distinct from PAS. Showing that these Cu-based compounds can act as new allosteric inhibitors of AChE and identifying novel allosteric binding site on AChE represents a significant contribution toward the design of novel and more effective inhibitors of AChE. © 2020 Elsevier Inc.
T2  - Journal of Inorganic Biochemistry
T1  - Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action
VL  - 205
SP  - 110990
DO  - 10.1016/j.jinorgbio.2019.110990
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Senćanski, Milan V. and Vujačić Nikezić, Ana V. and Kirillova, Marina V. and André, Vania and Kirillov, Alexander M. and Bondžić, Bojan P.",
year = "2020",
abstract = "Three coordination compounds featuring different types of tetracopper(II) cores, namely [O ⊂ Cu4N(CH2CH2O)34(BOH)4][BF4]2 (1), [Cu4(μ4-H2edte)(μ5-H2edte)(sal)2]n·7nH2O, (H4edte = N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine, H2sal = salicylic acid) (2), and [Cu4(μ3-Hbes)4(μ-hba)K(H2O)3]n, H3bes = N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (3), were assayed for their potency to inhibit the acetyl (AChE) and butyrylcholinesterase (BuChE) enzymes aiming to test these compounds as potential dual inhibitors in the treatment of Alzheimer's disease. All the investigated compounds showed a strong inhibitory potency toward both enzymes with IC50 values in micromolar range of concentration; compound 1 displayed the most potent inhibitory behaviour toward both enzymes. The mechanism of the AChE and BuChE inhibition was examined by enzyme kinetic measurements. The obtained kinetic parameters, Vmax and Km indicated an uncompetitive type of inhibition of both enzymes by compound 1. For the other two compounds a non-competitive inhibition mode was observed. To get further insight into the mechanism of action and to elucidate binding modes in details we examined the interactions of 1–3 with acetylcholinesterase, using molecular docking approach. Grid based docking studies indicated that these compounds can bind to peripheral anionic site (PAS) of the AChE with Ki values in micromolar range. Moreover, blind docking revealed the capability of investigated compounds to bind to new allosteric site (i.e. binding site II) distinct from PAS. Showing that these Cu-based compounds can act as new allosteric inhibitors of AChE and identifying novel allosteric binding site on AChE represents a significant contribution toward the design of novel and more effective inhibitors of AChE. © 2020 Elsevier Inc.",
journal = "Journal of Inorganic Biochemistry",
title = "Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action",
volume = "205",
pages = "110990",
doi = "10.1016/j.jinorgbio.2019.110990"
}

Bondžić, A. M., Senćanski, M. V., Vujačić Nikezić, A. V., Kirillova, M. V., André, V., Kirillov, A. M.,& Bondžić, B. P.. (2020). Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action. in Journal of Inorganic Biochemistry, 205, 110990.
https://doi.org/10.1016/j.jinorgbio.2019.110990

Bondžić AM, Senćanski MV, Vujačić Nikezić AV, Kirillova MV, André V, Kirillov AM, Bondžić BP. Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action. in Journal of Inorganic Biochemistry. 2020;205:110990.
doi:10.1016/j.jinorgbio.2019.110990 .

Bondžić, Aleksandra M., Senćanski, Milan V., Vujačić Nikezić, Ana V., Kirillova, Marina V., André, Vania, Kirillov, Alexander M., Bondžić, Bojan P., "Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action" in Journal of Inorganic Biochemistry, 205 (2020):110990,
https://doi.org/10.1016/j.jinorgbio.2019.110990 . .

TY  - CONF
AU  - Bondžić, Aleksandra M.
AU  - Vujačić Nikezić, Ana V.
AU  - Kirillov, Alexander M.
AU  - Bondžić, Bojan P.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12511
C3  - Fourth WG Meeting CA15135 : Final status of WG activities within MuTaLig COST Action : Book of Abstracts
T1  - Aminoalcoholate-driven tetracopper(II) cores as inhibitors of aggregation of β-amyloid
SP  - 56
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12511
ER  - 

@conference{
author = "Bondžić, Aleksandra M. and Vujačić Nikezić, Ana V. and Kirillov, Alexander M. and Bondžić, Bojan P.",
year = "2020",
journal = "Fourth WG Meeting CA15135 : Final status of WG activities within MuTaLig COST Action : Book of Abstracts",
title = "Aminoalcoholate-driven tetracopper(II) cores as inhibitors of aggregation of β-amyloid",
pages = "56-56",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12511"
}

Bondžić, A. M., Vujačić Nikezić, A. V., Kirillov, A. M.,& Bondžić, B. P.. (2020). Aminoalcoholate-driven tetracopper(II) cores as inhibitors of aggregation of β-amyloid. in Fourth WG Meeting CA15135 : Final status of WG activities within MuTaLig COST Action : Book of Abstracts, 56-56.
https://hdl.handle.net/21.15107/rcub_vinar_12511

Bondžić AM, Vujačić Nikezić AV, Kirillov AM, Bondžić BP. Aminoalcoholate-driven tetracopper(II) cores as inhibitors of aggregation of β-amyloid. in Fourth WG Meeting CA15135 : Final status of WG activities within MuTaLig COST Action : Book of Abstracts. 2020;:56-56.
https://hdl.handle.net/21.15107/rcub_vinar_12511 .

Bondžić, Aleksandra M., Vujačić Nikezić, Ana V., Kirillov, Alexander M., Bondžić, Bojan P., "Aminoalcoholate-driven tetracopper(II) cores as inhibitors of aggregation of β-amyloid" in Fourth WG Meeting CA15135 : Final status of WG activities within MuTaLig COST Action : Book of Abstracts (2020):56-56,
https://hdl.handle.net/21.15107/rcub_vinar_12511 .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Čolović, Mirjana B.
AU  - Parac-Vogt, Tatjana N.
AU  - Janjić, Goran V.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9028
AB  - Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.
T2  - European Journal of Pharmaceutical Sciences
T1  - A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition
VL  - 151
SP  - 105376
DO  - 10.1016/j.ejps.2020.105376
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Lazarević-Pašti, Tamara and Leskovac, Andreja and Petrović, Sandra and Čolović, Mirjana B. and Parac-Vogt, Tatjana N. and Janjić, Goran V.",
year = "2020",
abstract = "Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.",
journal = "European Journal of Pharmaceutical Sciences",
title = "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition",
volume = "151",
pages = "105376",
doi = "10.1016/j.ejps.2020.105376"
}

Bondžić, A. M., Lazarević-Pašti, T., Leskovac, A., Petrović, S., Čolović, M. B., Parac-Vogt, T. N.,& Janjić, G. V.. (2020). A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences, 151, 105376.
https://doi.org/10.1016/j.ejps.2020.105376

Bondžić AM, Lazarević-Pašti T, Leskovac A, Petrović S, Čolović MB, Parac-Vogt TN, Janjić GV. A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences. 2020;151:105376.
doi:10.1016/j.ejps.2020.105376 .

Bondžić, Aleksandra M., Lazarević-Pašti, Tamara, Leskovac, Andreja, Petrović, Sandra, Čolović, Mirjana B., Parac-Vogt, Tatjana N., Janjić, Goran V., "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition" in European Journal of Pharmaceutical Sciences, 151 (2020):105376,
https://doi.org/10.1016/j.ejps.2020.105376 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Vujačić Nikezić, Ana V.
AU  - Klekotka,  Urszula
AU  - Marković, Mirjana
AU  - Vodnik, Vesna
AU  - Kalska, B.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8812
AB  - Abstract: This paper presents the study of the interaction between gold nanoparticles (AuNPs) and antitumor gold complexes, [Au(OH)2(bipy)][PF6], [Au(CH3COO)2(pydmb-H)], and [Au(bipydmb-H)(OH)][PF6], in order to estimate the possibility for metal complex tracking in cells using nanospectroscopy approach. Decrease of intensity of the surface plasmon absorption band at 524 nm and the appearance of a new broad band at ∼640 nm, followed by their red shift were observed in the presence of the complexes. TEM images showed that the average size and shape of AuNPs did not change after the addition of gold complexes. DLS and zeta potential measurements pointed out to the metal complex adsorption on the surface of AuNPs followed by flocculation process. In addition, kinetic studies indicated strong bond formation between these complexes and AuNPs. Accordingly, AuNPs/complex conjugates have the potential to be applied for the tracking of these metal complexes in the cells using nanospectroscopy approach. © 2019, Pleiades Publishing, Ltd.
T2  - Russian Journal of Physical Chemistry A
T1  - Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles
VL  - 93
IS  - 13
SP  - 2765
EP  - 2770
DO  - 10.1134/S0036024419130065
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Vujačić Nikezić, Ana V. and Klekotka,  Urszula and Marković, Mirjana and Vodnik, Vesna and Kalska, B. and Vasić, Vesna M.",
year = "2019",
abstract = "Abstract: This paper presents the study of the interaction between gold nanoparticles (AuNPs) and antitumor gold complexes, [Au(OH)2(bipy)][PF6], [Au(CH3COO)2(pydmb-H)], and [Au(bipydmb-H)(OH)][PF6], in order to estimate the possibility for metal complex tracking in cells using nanospectroscopy approach. Decrease of intensity of the surface plasmon absorption band at 524 nm and the appearance of a new broad band at ∼640 nm, followed by their red shift were observed in the presence of the complexes. TEM images showed that the average size and shape of AuNPs did not change after the addition of gold complexes. DLS and zeta potential measurements pointed out to the metal complex adsorption on the surface of AuNPs followed by flocculation process. In addition, kinetic studies indicated strong bond formation between these complexes and AuNPs. Accordingly, AuNPs/complex conjugates have the potential to be applied for the tracking of these metal complexes in the cells using nanospectroscopy approach. © 2019, Pleiades Publishing, Ltd.",
journal = "Russian Journal of Physical Chemistry A",
title = "Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles",
volume = "93",
number = "13",
pages = "2765-2770",
doi = "10.1134/S0036024419130065"
}

Bondžić, A. M., Vujačić Nikezić, A. V., Klekotka, U., Marković, M., Vodnik, V., Kalska, B.,& Vasić, V. M.. (2019). Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles. in Russian Journal of Physical Chemistry A, 93(13), 2765-2770.
https://doi.org/10.1134/S0036024419130065

Bondžić AM, Vujačić Nikezić AV, Klekotka U, Marković M, Vodnik V, Kalska B, Vasić VM. Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles. in Russian Journal of Physical Chemistry A. 2019;93(13):2765-2770.
doi:10.1134/S0036024419130065 .

Bondžić, Aleksandra M., Vujačić Nikezić, Ana V., Klekotka,  Urszula, Marković, Mirjana, Vodnik, Vesna, Kalska, B., Vasić, Vesna M., "Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles" in Russian Journal of Physical Chemistry A, 93, no. 13 (2019):2765-2770,
https://doi.org/10.1134/S0036024419130065 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Vasić Anićijević, Dragana D.
AU  - Luce, Marco
AU  - Massai, Lara
AU  - Generosi, Amanda
AU  - Paci, Barbara
AU  - Cricenti, Antonio
AU  - Messori, Luigi
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8747
AB  - Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)2][PF6], where (N,N)=2,2′-bipyridine; [Au(C,N)(AcO)2], where (C,N)=deprotonated 6-(1,1-dimethylbenzyl)-pyridine; [Au(C,N,N)(OH)][PF6], where (C,N,N)=deprotonated 6-(1,1-dimethylbenzyl)-2,2′-bipyridine, to assess the chance of tracking their subcellular distribution by atomic force microscopy (AFM), and surface enhanced Raman spectroscopy (SERS) techniques. An extensive physicochemical characterization of the formed conjugates was, thus, carried out by applying a variety of methods (density functional theory—DFT, UV/Vis spectrophotometry, AFM, Raman spectroscopy, and SERS). The resulting gold(III) complexes/AuNPs conjugates turned out to be pretty stable. Interestingly, they exhibited a dramatically increased resonance intensity in the Raman spectra induced by AuNPs. For testing the use of the functionalized AuNPs for biosensing, their distribution in the nuclear, cytosolic, and membrane cell fractions obtained from human lymphocytes was investigated by AFM and SERS. The conjugates were detected in the membrane and nuclear cell fractions but not in the cytosol. The AFM method confirmed that conjugates induced changes in the morphology and nanostructure of the membrane and nuclear fractions. The obtained results point out that the conjugates formed between AuNPs and gold(III) complexes may be used as a tool for tracking metallodrug distribution in the different cell fractions.
T2  - International Journal of Molecular Sciences
T1  - Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue
VL  - 20
IS  - 24
SP  - 6306
DO  - 10.3390/ijms20246306
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Leskovac, Andreja and Petrović, Sandra and Vasić Anićijević, Dragana D. and Luce, Marco and Massai, Lara and Generosi, Amanda and Paci, Barbara and Cricenti, Antonio and Messori, Luigi and Vasić, Vesna M.",
year = "2019",
abstract = "Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)2][PF6], where (N,N)=2,2′-bipyridine; [Au(C,N)(AcO)2], where (C,N)=deprotonated 6-(1,1-dimethylbenzyl)-pyridine; [Au(C,N,N)(OH)][PF6], where (C,N,N)=deprotonated 6-(1,1-dimethylbenzyl)-2,2′-bipyridine, to assess the chance of tracking their subcellular distribution by atomic force microscopy (AFM), and surface enhanced Raman spectroscopy (SERS) techniques. An extensive physicochemical characterization of the formed conjugates was, thus, carried out by applying a variety of methods (density functional theory—DFT, UV/Vis spectrophotometry, AFM, Raman spectroscopy, and SERS). The resulting gold(III) complexes/AuNPs conjugates turned out to be pretty stable. Interestingly, they exhibited a dramatically increased resonance intensity in the Raman spectra induced by AuNPs. For testing the use of the functionalized AuNPs for biosensing, their distribution in the nuclear, cytosolic, and membrane cell fractions obtained from human lymphocytes was investigated by AFM and SERS. The conjugates were detected in the membrane and nuclear cell fractions but not in the cytosol. The AFM method confirmed that conjugates induced changes in the morphology and nanostructure of the membrane and nuclear fractions. The obtained results point out that the conjugates formed between AuNPs and gold(III) complexes may be used as a tool for tracking metallodrug distribution in the different cell fractions.",
journal = "International Journal of Molecular Sciences",
title = "Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue",
volume = "20",
number = "24",
pages = "6306",
doi = "10.3390/ijms20246306"
}

Bondžić, A. M., Leskovac, A., Petrović, S., Vasić Anićijević, D. D., Luce, M., Massai, L., Generosi, A., Paci, B., Cricenti, A., Messori, L.,& Vasić, V. M.. (2019). Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue. in International Journal of Molecular Sciences, 20(24), 6306.
https://doi.org/10.3390/ijms20246306

Bondžić AM, Leskovac A, Petrović S, Vasić Anićijević DD, Luce M, Massai L, Generosi A, Paci B, Cricenti A, Messori L, Vasić VM. Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue. in International Journal of Molecular Sciences. 2019;20(24):6306.
doi:10.3390/ijms20246306 .

Bondžić, Aleksandra M., Leskovac, Andreja, Petrović, Sandra, Vasić Anićijević, Dragana D., Luce, Marco, Massai, Lara, Generosi, Amanda, Paci, Barbara, Cricenti, Antonio, Messori, Luigi, Vasić, Vesna M., "Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue" in International Journal of Molecular Sciences, 20, no. 24 (2019):6306,
https://doi.org/10.3390/ijms20246306 . .

TY  - JOUR
AU  - Vujačić Nikezić, Ana V.
AU  - Janjić, Goran V.
AU  - Bondžić, Aleksandra M.
AU  - Zarić, Božidarka
AU  - Vasić Anićijević, Dragana D.
AU  - Momić, Tatjana
AU  - Vasić, Vesna M.
PY  - 2018
UR  - http://xlink.rsc.org/?DOI=C8MT00111A
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7812
AB  - The present paper deals with investigation of the interaction between selected simple structure Au(iii) ([AuCl4]-, [AuCl2(dmso)2]+, [AuCl2(bipy)]+) and Pt(ii) ([PtCl2(dmso)2]) complexes with Na/K-ATPase as the target enzyme, using an experimental and theoretical approach. Reaction stoichiometries and binding constants for these enzyme/complex systems were determined, while kinetic measurements were used in order to reveal the type of inhibition. Based on the results obtained by quantum mechanical calculations (electrostatic surface potential (ESP), volume and surface of the complexes) the nature of the investigated complexes was characterized. By using the solvent accessible surface area (SASA) applied on specific inhibitory sites (ion channel and intracellular domains) the nature of these sites was described. Docking studies were used to determine the theoretical probability of the non-covalent metal binding site positions. Inhibition studies implied that all the investigated complexes decreased the activity of the enzyme while the kinetic analysis indicated an uncompetitive mode of inhibition for the selected complexes. Docking results suggested that the main inhibitory site of all these complexes is located in the ion translocation pathway on the extracellular side in the E2P enzyme conformation, similar to the case of cardiac glycosides, specific Na/K-ATPase inhibitors. Also, based on our knowledge, the hydrolyzed forms of [AuCl4]- and [PtCl2(dmso)2] complexes were investigated for the first time by theoretical calculations in this paper. Thereby, a new inhibitory site situated between the M2 and M4 helices was revealed. Binding in this site induces conformational changes in the enzyme domains and perturbs the E1-E2P conformational equilibrium, causing enzyme inhibition.
T2  - Metallomics
T1  - Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites
VL  - 10
IS  - 7
SP  - 1003
EP  - 1015
DO  - 10.1039/C8MT00111A
ER  - 

@article{
author = "Vujačić Nikezić, Ana V. and Janjić, Goran V. and Bondžić, Aleksandra M. and Zarić, Božidarka and Vasić Anićijević, Dragana D. and Momić, Tatjana and Vasić, Vesna M.",
year = "2018",
abstract = "The present paper deals with investigation of the interaction between selected simple structure Au(iii) ([AuCl4]-, [AuCl2(dmso)2]+, [AuCl2(bipy)]+) and Pt(ii) ([PtCl2(dmso)2]) complexes with Na/K-ATPase as the target enzyme, using an experimental and theoretical approach. Reaction stoichiometries and binding constants for these enzyme/complex systems were determined, while kinetic measurements were used in order to reveal the type of inhibition. Based on the results obtained by quantum mechanical calculations (electrostatic surface potential (ESP), volume and surface of the complexes) the nature of the investigated complexes was characterized. By using the solvent accessible surface area (SASA) applied on specific inhibitory sites (ion channel and intracellular domains) the nature of these sites was described. Docking studies were used to determine the theoretical probability of the non-covalent metal binding site positions. Inhibition studies implied that all the investigated complexes decreased the activity of the enzyme while the kinetic analysis indicated an uncompetitive mode of inhibition for the selected complexes. Docking results suggested that the main inhibitory site of all these complexes is located in the ion translocation pathway on the extracellular side in the E2P enzyme conformation, similar to the case of cardiac glycosides, specific Na/K-ATPase inhibitors. Also, based on our knowledge, the hydrolyzed forms of [AuCl4]- and [PtCl2(dmso)2] complexes were investigated for the first time by theoretical calculations in this paper. Thereby, a new inhibitory site situated between the M2 and M4 helices was revealed. Binding in this site induces conformational changes in the enzyme domains and perturbs the E1-E2P conformational equilibrium, causing enzyme inhibition.",
journal = "Metallomics",
title = "Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites",
volume = "10",
number = "7",
pages = "1003-1015",
doi = "10.1039/C8MT00111A"
}

Vujačić Nikezić, A. V., Janjić, G. V., Bondžić, A. M., Zarić, B., Vasić Anićijević, D. D., Momić, T.,& Vasić, V. M.. (2018). Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites. in Metallomics, 10(7), 1003-1015.
https://doi.org/10.1039/C8MT00111A

Vujačić Nikezić AV, Janjić GV, Bondžić AM, Zarić B, Vasić Anićijević DD, Momić T, Vasić VM. Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites. in Metallomics. 2018;10(7):1003-1015.
doi:10.1039/C8MT00111A .

Vujačić Nikezić, Ana V., Janjić, Goran V., Bondžić, Aleksandra M., Zarić, Božidarka, Vasić Anićijević, Dragana D., Momić, Tatjana, Vasić, Vesna M., "Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites" in Metallomics, 10, no. 7 (2018):1003-1015,
https://doi.org/10.1039/C8MT00111A . .

TY  - CONF
AU  - Čolović, Mirjana
AU  - Bondžić, Aleksandra M.
AU  - Vujačić Nikezić, Ana V.
AU  - Krstić, Danijela
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12976
AB  - In vitro oxidative stress responses of two Keggin-type polyoxotungstates, 12- tungstosilicic (WSiA) and 12-tungstophosphoric acid (WPA), were investigated using rat synaptosomes as a model system. WSiA induced concentration-dependent increase in catalase activity, up to about 6 times compared to the control activity in untreated synaptosomes, and glutathione peroxidase was not significantly affected after WSiA treatment. On the contrary, WPA treatment resulted in the increase of glutathione peroxidase activity, while synaptosomal catalase was even reduced related to the control, at all investigated WPA concentrations. Both investigated polyoxotungstates did not significantly change malondialdehyde content in synaptosomal preparations. It could accordingly be concluded that WSiA and WPA probably induce reactive oxygen species generation, resulting in the activation of the antioxidant defense enzymes. However, these polyoxotungstates are not strong prooxidants being able to cause oxidative stress, and consequently synaptosomal membrane lipid damage.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
T1  - Oxidative stress responses of 12-Tungstosilicic and 12-Tungstophosphoric acid
VL  - 1
SP  - 511
EP  - 514
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12976
ER  - 

@conference{
author = "Čolović, Mirjana and Bondžić, Aleksandra M. and Vujačić Nikezić, Ana V. and Krstić, Danijela",
year = "2018",
abstract = "In vitro oxidative stress responses of two Keggin-type polyoxotungstates, 12- tungstosilicic (WSiA) and 12-tungstophosphoric acid (WPA), were investigated using rat synaptosomes as a model system. WSiA induced concentration-dependent increase in catalase activity, up to about 6 times compared to the control activity in untreated synaptosomes, and glutathione peroxidase was not significantly affected after WSiA treatment. On the contrary, WPA treatment resulted in the increase of glutathione peroxidase activity, while synaptosomal catalase was even reduced related to the control, at all investigated WPA concentrations. Both investigated polyoxotungstates did not significantly change malondialdehyde content in synaptosomal preparations. It could accordingly be concluded that WSiA and WPA probably induce reactive oxygen species generation, resulting in the activation of the antioxidant defense enzymes. However, these polyoxotungstates are not strong prooxidants being able to cause oxidative stress, and consequently synaptosomal membrane lipid damage.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings",
title = "Oxidative stress responses of 12-Tungstosilicic and 12-Tungstophosphoric acid",
volume = "1",
pages = "511-514",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12976"
}

Čolović, M., Bondžić, A. M., Vujačić Nikezić, A. V.,& Krstić, D.. (2018). Oxidative stress responses of 12-Tungstosilicic and 12-Tungstophosphoric acid. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 511-514.
https://hdl.handle.net/21.15107/rcub_vinar_12976

Čolović M, Bondžić AM, Vujačić Nikezić AV, Krstić D. Oxidative stress responses of 12-Tungstosilicic and 12-Tungstophosphoric acid. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings. 2018;1:511-514.
https://hdl.handle.net/21.15107/rcub_vinar_12976 .

Čolović, Mirjana, Bondžić, Aleksandra M., Vujačić Nikezić, Ana V., Krstić, Danijela, "Oxidative stress responses of 12-Tungstosilicic and 12-Tungstophosphoric acid" in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings, 1 (2018):511-514,
https://hdl.handle.net/21.15107/rcub_vinar_12976 .

TY  - CONF
AU  - Bondžić, Aleksandra M.
AU  - Parac-Vogt, Tatjana
AU  - Vujačić Nikezić, Ana V.
AU  - Krstić, Danijela
AU  - Čolović, Mirjana
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12977
AB  - Inhibition of acetylcholinesterase (AChE) is presented as a promising strategy in the treatment of Alzheimer disease providing inspiration for new discoveries and investigations less toxic and more effective potential anti Alzheimer drugs. In this paper, it demonstrated that the activity of acetylcholinesterase can be effectively inhibited by polyoxometalates (POMs), 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA) without significant changes on the secondary structure of this enzyme. The obtained values of partition coefficient implicated on smooth pass of these POMs trough cell membrane and satisfied necessary criteria for the drugs used in the treatment of the central nervous system disease. Based on these obtained results it is possible to conclude that POM could represent new generation of potential anti Alzheimer drugs.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
T1  - Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase
VL  - 1
SP  - 503
EP  - 506
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12977
ER  - 

@conference{
author = "Bondžić, Aleksandra M. and Parac-Vogt, Tatjana and Vujačić Nikezić, Ana V. and Krstić, Danijela and Čolović, Mirjana",
year = "2018",
abstract = "Inhibition of acetylcholinesterase (AChE) is presented as a promising strategy in the treatment of Alzheimer disease providing inspiration for new discoveries and investigations less toxic and more effective potential anti Alzheimer drugs. In this paper, it demonstrated that the activity of acetylcholinesterase can be effectively inhibited by polyoxometalates (POMs), 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA) without significant changes on the secondary structure of this enzyme. The obtained values of partition coefficient implicated on smooth pass of these POMs trough cell membrane and satisfied necessary criteria for the drugs used in the treatment of the central nervous system disease. Based on these obtained results it is possible to conclude that POM could represent new generation of potential anti Alzheimer drugs.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings",
title = "Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase",
volume = "1",
pages = "503-506",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12977"
}

Bondžić, A. M., Parac-Vogt, T., Vujačić Nikezić, A. V., Krstić, D.,& Čolović, M.. (2018). Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 503-506.
https://hdl.handle.net/21.15107/rcub_vinar_12977

Bondžić AM, Parac-Vogt T, Vujačić Nikezić AV, Krstić D, Čolović M. Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings. 2018;1:503-506.
https://hdl.handle.net/21.15107/rcub_vinar_12977 .

Bondžić, Aleksandra M., Parac-Vogt, Tatjana, Vujačić Nikezić, Ana V., Krstić, Danijela, Čolović, Mirjana, "Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase" in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings, 1 (2018):503-506,
https://hdl.handle.net/21.15107/rcub_vinar_12977 .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Janjić, G.
AU  - Marković, M.
AU  - Zeković, I.
AU  - Leskovac, Andreja
AU  - Cricentia, A.
AU  - Lucea, M.
AU  - Vasić, Vesna M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11713
C3  - 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal
T1  - Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism
SP  - 111
EP  - 111
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11713
ER  - 

@conference{
author = "Bondžić, Aleksandra and Janjić, G. and Marković, M. and Zeković, I. and Leskovac, Andreja and Cricentia, A. and Lucea, M. and Vasić, Vesna M.",
year = "2017",
journal = "4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal",
title = "Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism",
pages = "111-111",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11713"
}

Bondžić, A., Janjić, G., Marković, M., Zeković, I., Leskovac, A., Cricentia, A., Lucea, M.,& Vasić, V. M.. (2017). Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism. in 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal, 111-111.
https://hdl.handle.net/21.15107/rcub_vinar_11713

Bondžić A, Janjić G, Marković M, Zeković I, Leskovac A, Cricentia A, Lucea M, Vasić VM. Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism. in 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal. 2017;:111-111.
https://hdl.handle.net/21.15107/rcub_vinar_11713 .

Bondžić, Aleksandra, Janjić, G., Marković, M., Zeković, I., Leskovac, Andreja, Cricentia, A., Lucea, M., Vasić, Vesna M., "Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism" in 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal (2017):111-111,
https://hdl.handle.net/21.15107/rcub_vinar_11713 .