TY  - JOUR
AU  - Šojić Merkulov, Daniela V.
AU  - Lazarević, Marina J.
AU  - Đorđević, Aleksandar N.
AU  - Náfrádi, Máté
AU  - Alapi, Tünde
AU  - Putnik, Predrag
AU  - Rakočević, Zlatko Lj.
AU  - Novaković, Mirjana M.
AU  - Miljević, Bojan
AU  - Bognár, Szabolcs
AU  - Abramović, Biljana F.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9588
AB  - Nowadays, great focus is given to the contamination of surface and groundwater because of the extensive usage of pesticides in agriculture. The improvements of commercial catalyst TiO2 activity using different Au nanoparticles were investigated for mesotrione photocatalytic degradation under simulated sunlight. The selected system was 2.43 × 10−3% Au–S–CH2–CH2–OH/TiO2 (0.5 g/L) that was studied by transmission electron microscopy and ultraviolet-visible (UV-Vis) spectroscopy. It was found that TiO2 particles size was ~20 nm and ~50 nm, respectively. The Au nanoparticles were below 10 nm and were well distributed within the framework of TiO2 . For 2.43 × 10−3% Au–S–CH2–CH2–OH/TiO2 (0.5 g/L), band gap energy was 2.45 eV. In comparison to the pure TiO2, addition of Au nanoparticles generally enhanced photocatalytic removal of mesotrione. By examining the degree of mineralization, it was found that 2.43 × 10−3% Au–S–CH2–CH2–OH/TiO2 (0.5 g/L) system was the most efficient for the removal of the mesotrione and intermediates. The effect of tert-butanol, NaF and ethylenediaminetetraacetic acid disodium salt on the transformation rate suggested that the relative contribution of various reactive species changed in following order: h+ >•OHads >•OHbulk. Finally, several intermediates that were formed during the photocatalytic treatment of mesotrione were identified. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
T2  - Nanomaterials
T1  - Potential of TiO2 with various au nanoparticles for catalyzing mesotrione removal from wastewaters under sunlight
VL  - 10
IS  - 8
SP  - 1
EP  - 15
DO  - 10.3390/nano10081591
ER  - 

@article{
author = "Šojić Merkulov, Daniela V. and Lazarević, Marina J. and Đorđević, Aleksandar N. and Náfrádi, Máté and Alapi, Tünde and Putnik, Predrag and Rakočević, Zlatko Lj. and Novaković, Mirjana M. and Miljević, Bojan and Bognár, Szabolcs and Abramović, Biljana F.",
year = "2020",
abstract = "Nowadays, great focus is given to the contamination of surface and groundwater because of the extensive usage of pesticides in agriculture. The improvements of commercial catalyst TiO2 activity using different Au nanoparticles were investigated for mesotrione photocatalytic degradation under simulated sunlight. The selected system was 2.43 × 10−3% Au–S–CH2–CH2–OH/TiO2 (0.5 g/L) that was studied by transmission electron microscopy and ultraviolet-visible (UV-Vis) spectroscopy. It was found that TiO2 particles size was ~20 nm and ~50 nm, respectively. The Au nanoparticles were below 10 nm and were well distributed within the framework of TiO2 . For 2.43 × 10−3% Au–S–CH2–CH2–OH/TiO2 (0.5 g/L), band gap energy was 2.45 eV. In comparison to the pure TiO2, addition of Au nanoparticles generally enhanced photocatalytic removal of mesotrione. By examining the degree of mineralization, it was found that 2.43 × 10−3% Au–S–CH2–CH2–OH/TiO2 (0.5 g/L) system was the most efficient for the removal of the mesotrione and intermediates. The effect of tert-butanol, NaF and ethylenediaminetetraacetic acid disodium salt on the transformation rate suggested that the relative contribution of various reactive species changed in following order: h+ >•OHads >•OHbulk. Finally, several intermediates that were formed during the photocatalytic treatment of mesotrione were identified. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
journal = "Nanomaterials",
title = "Potential of TiO2 with various au nanoparticles for catalyzing mesotrione removal from wastewaters under sunlight",
volume = "10",
number = "8",
pages = "1-15",
doi = "10.3390/nano10081591"
}

Šojić Merkulov, D. V., Lazarević, M. J., Đorđević, A. N., Náfrádi, M., Alapi, T., Putnik, P., Rakočević, Z. Lj., Novaković, M. M., Miljević, B., Bognár, S.,& Abramović, B. F.. (2020). Potential of TiO2 with various au nanoparticles for catalyzing mesotrione removal from wastewaters under sunlight. in Nanomaterials, 10(8), 1-15.
https://doi.org/10.3390/nano10081591

Šojić Merkulov DV, Lazarević MJ, Đorđević AN, Náfrádi M, Alapi T, Putnik P, Rakočević ZL, Novaković MM, Miljević B, Bognár S, Abramović BF. Potential of TiO2 with various au nanoparticles for catalyzing mesotrione removal from wastewaters under sunlight. in Nanomaterials. 2020;10(8):1-15.
doi:10.3390/nano10081591 .

Šojić Merkulov, Daniela V., Lazarević, Marina J., Đorđević, Aleksandar N., Náfrádi, Máté, Alapi, Tünde, Putnik, Predrag, Rakočević, Zlatko Lj., Novaković, Mirjana M., Miljević, Bojan, Bognár, Szabolcs, Abramović, Biljana F., "Potential of TiO2 with various au nanoparticles for catalyzing mesotrione removal from wastewaters under sunlight" in Nanomaterials, 10, no. 8 (2020):1-15,
https://doi.org/10.3390/nano10081591 . .

TY  - JOUR
AU  - Radmanović, Svjetlana B.
AU  - Gajić-Kvaščev, Maja 
AU  - Mrvić, Vesna
AU  - Đorđević, Aleksandar
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9755
AB  - According to the Serbian official soil classification system, Rendzina is a soil type with an A-AC-C-R profile, developed on parent rock containing more than 20% of calcareous material (except soils with an A-R profile on hard pure limestone or dolomite). Previous investigations have shown that 29 Rendzina soil profiles from Serbia belong to the reference soil groups (RSGs) of Leptosols, Regosols and Phaeozems according to the World Reference Base for Soil Resources (WRB 2015). The present study addresses the correlations among three WRB RSGs in terms of soil texture, mean weight diameter (MWD), total N content, and humus fractional composition using Principal Component Analysis (PCA). The objective is to better understand the mutual relationship between the classification soil units used in Serbia and the international WRB system. The results show that PCA cannot unequivocally distinguish between these three RSGs. Leptosols and Regosols are highly incoherent groups while the group of Phaeozems is highly coherent, leading to the conclusion that the physical and chemical properties of the soil profiles of Phaoeozems are specific. It is obvious that soil depth and color, which are the overriding factors in the differentiation of Rendzina soils into three WRB RSGs, had no significant effect on these properties. The results further show that soil properties such as texture, MWD, humus fractional composition, etc. cannot be used to correlate Rendzina soils from Serbia with WRB. Instead, careful correlation of individual soil profiles is needed based on quantitative soil data analysis as required by WRB.
T2  - Journal of Agricultural Sciences (Belgrade)
T1  - Characteristics of Rendzina soils in Serbia and their WRB classification
VL  - 65
IS  - 3
SP  - 251
EP  - 261
DO  - 10.2298/JAS2003251R
ER  - 

@article{
author = "Radmanović, Svjetlana B. and Gajić-Kvaščev, Maja  and Mrvić, Vesna and Đorđević, Aleksandar",
year = "2020",
abstract = "According to the Serbian official soil classification system, Rendzina is a soil type with an A-AC-C-R profile, developed on parent rock containing more than 20% of calcareous material (except soils with an A-R profile on hard pure limestone or dolomite). Previous investigations have shown that 29 Rendzina soil profiles from Serbia belong to the reference soil groups (RSGs) of Leptosols, Regosols and Phaeozems according to the World Reference Base for Soil Resources (WRB 2015). The present study addresses the correlations among three WRB RSGs in terms of soil texture, mean weight diameter (MWD), total N content, and humus fractional composition using Principal Component Analysis (PCA). The objective is to better understand the mutual relationship between the classification soil units used in Serbia and the international WRB system. The results show that PCA cannot unequivocally distinguish between these three RSGs. Leptosols and Regosols are highly incoherent groups while the group of Phaeozems is highly coherent, leading to the conclusion that the physical and chemical properties of the soil profiles of Phaoeozems are specific. It is obvious that soil depth and color, which are the overriding factors in the differentiation of Rendzina soils into three WRB RSGs, had no significant effect on these properties. The results further show that soil properties such as texture, MWD, humus fractional composition, etc. cannot be used to correlate Rendzina soils from Serbia with WRB. Instead, careful correlation of individual soil profiles is needed based on quantitative soil data analysis as required by WRB.",
journal = "Journal of Agricultural Sciences (Belgrade)",
title = "Characteristics of Rendzina soils in Serbia and their WRB classification",
volume = "65",
number = "3",
pages = "251-261",
doi = "10.2298/JAS2003251R"
}

Radmanović, S. B., Gajić-Kvaščev, M., Mrvić, V.,& Đorđević, A.. (2020). Characteristics of Rendzina soils in Serbia and their WRB classification. in Journal of Agricultural Sciences (Belgrade), 65(3), 251-261.
https://doi.org/10.2298/JAS2003251R

Radmanović SB, Gajić-Kvaščev M, Mrvić V, Đorđević A. Characteristics of Rendzina soils in Serbia and their WRB classification. in Journal of Agricultural Sciences (Belgrade). 2020;65(3):251-261.
doi:10.2298/JAS2003251R .

Radmanović, Svjetlana B., Gajić-Kvaščev, Maja , Mrvić, Vesna, Đorđević, Aleksandar, "Characteristics of Rendzina soils in Serbia and their WRB classification" in Journal of Agricultural Sciences (Belgrade), 65, no. 3 (2020):251-261,
https://doi.org/10.2298/JAS2003251R . .

TY  - JOUR
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Labudović-Borović, Milica
AU  - Borisev, Ivana
AU  - Novaković, Mirjana M.
AU  - Rakočević, Zlatko Lj.
AU  - Đorđević, Aleksandar N.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8649
AB  - Fullerenol C60(OH)24 with its spherical shape, symmetrical structure, 1 nm size and the ability to form polyionic nanoparticles in water solution, was used to synthesise a novel nanocomposite made of fullerenol nanoparticles (FNP) and iron ions (Fe2+). The FNP/Fe2+ nanocomposite was characterised by DLS and TEM-EDS analyses which have shown that the size distribution of FNP/Fe2+ stayed in the same scope as the size distribution of FNP, ranging from 11 to 60 nm. However, Fe2+ did affect the change of FNP’s zeta potential (− 49.2 mV), shifting it to more positive values (− 30.8 mV). In this study, it was assumed that FNP/Fe2+ could reduce the toxic effects of doxorubicin (Dox). Male Wistar rats were treated i.p. with FNP/Fe2+ nanocomposite 1 h prior to Dox treatment. At the subcellular level, the ultrastructural analysis revealed minor alterations sporadically displayed within the heart and liver tissues. Moreover, at the molecular level, the gene expressions analysis of mRNAs for catalase (heart and liver) and MnSOD (only liver) were significantly downregulated, indicating reduction in oxidative stress. Overall, the pretreatment with FNP/Fe2+ nanocomposite, followed by Dox application, significantly diminished harmful effects of the applied drug on the heart and liver, suggesting the potential protective effect of the nanocomposite on the healthy tissues. © 2019, Springer Nature B.V.
T2  - Journal of Nanoparticle Research
T1  - Fullerenol/iron nanocomposite diminishes doxorubicin-induced toxicity
VL  - 21
IS  - 11
SP  - 239
DO  - 10.1007/s11051-019-4681-4
ER  - 

@article{
author = "Seke, Mariana and Petrović, Danijela and Labudović-Borović, Milica and Borisev, Ivana and Novaković, Mirjana M. and Rakočević, Zlatko Lj. and Đorđević, Aleksandar N.",
year = "2019",
abstract = "Fullerenol C60(OH)24 with its spherical shape, symmetrical structure, 1 nm size and the ability to form polyionic nanoparticles in water solution, was used to synthesise a novel nanocomposite made of fullerenol nanoparticles (FNP) and iron ions (Fe2+). The FNP/Fe2+ nanocomposite was characterised by DLS and TEM-EDS analyses which have shown that the size distribution of FNP/Fe2+ stayed in the same scope as the size distribution of FNP, ranging from 11 to 60 nm. However, Fe2+ did affect the change of FNP’s zeta potential (− 49.2 mV), shifting it to more positive values (− 30.8 mV). In this study, it was assumed that FNP/Fe2+ could reduce the toxic effects of doxorubicin (Dox). Male Wistar rats were treated i.p. with FNP/Fe2+ nanocomposite 1 h prior to Dox treatment. At the subcellular level, the ultrastructural analysis revealed minor alterations sporadically displayed within the heart and liver tissues. Moreover, at the molecular level, the gene expressions analysis of mRNAs for catalase (heart and liver) and MnSOD (only liver) were significantly downregulated, indicating reduction in oxidative stress. Overall, the pretreatment with FNP/Fe2+ nanocomposite, followed by Dox application, significantly diminished harmful effects of the applied drug on the heart and liver, suggesting the potential protective effect of the nanocomposite on the healthy tissues. © 2019, Springer Nature B.V.",
journal = "Journal of Nanoparticle Research",
title = "Fullerenol/iron nanocomposite diminishes doxorubicin-induced toxicity",
volume = "21",
number = "11",
pages = "239",
doi = "10.1007/s11051-019-4681-4"
}

Seke, M., Petrović, D., Labudović-Borović, M., Borisev, I., Novaković, M. M., Rakočević, Z. Lj.,& Đorđević, A. N.. (2019). Fullerenol/iron nanocomposite diminishes doxorubicin-induced toxicity. in Journal of Nanoparticle Research, 21(11), 239.
https://doi.org/10.1007/s11051-019-4681-4

Seke M, Petrović D, Labudović-Borović M, Borisev I, Novaković MM, Rakočević ZL, Đorđević AN. Fullerenol/iron nanocomposite diminishes doxorubicin-induced toxicity. in Journal of Nanoparticle Research. 2019;21(11):239.
doi:10.1007/s11051-019-4681-4 .

Seke, Mariana, Petrović, Danijela, Labudović-Borović, Milica, Borisev, Ivana, Novaković, Mirjana M., Rakočević, Zlatko Lj., Đorđević, Aleksandar N., "Fullerenol/iron nanocomposite diminishes doxorubicin-induced toxicity" in Journal of Nanoparticle Research, 21, no. 11 (2019):239,
https://doi.org/10.1007/s11051-019-4681-4 . .

TY  - JOUR
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Labudović-Borović, Milica
AU  - Jović, Danica S.
AU  - Borišev, Ivana
AU  - Srđenović, Branislava U.
AU  - Rakočević, Zlatko Lj.
AU  - Pavlović, Vladimir B.
AU  - Đorđević, Aleksandar N.
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0014480017305890
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7688
AB  - In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats.
T2  - Experimental and Molecular Pathology
T1  - Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats
VL  - 104
IS  - 3
SP  - 199
EP  - 211
DO  - 10.1016/j.yexmp.2018.04.005
ER  - 

@article{
author = "Petrović, Danijela and Seke, Mariana and Labudović-Borović, Milica and Jović, Danica S. and Borišev, Ivana and Srđenović, Branislava U. and Rakočević, Zlatko Lj. and Pavlović, Vladimir B. and Đorđević, Aleksandar N.",
year = "2018",
abstract = "In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats.",
journal = "Experimental and Molecular Pathology",
title = "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats",
volume = "104",
number = "3",
pages = "199-211",
doi = "10.1016/j.yexmp.2018.04.005"
}

Petrović, D., Seke, M., Labudović-Borović, M., Jović, D. S., Borišev, I., Srđenović, B. U., Rakočević, Z. Lj., Pavlović, V. B.,& Đorđević, A. N.. (2018). Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats. in Experimental and Molecular Pathology, 104(3), 199-211.
https://doi.org/10.1016/j.yexmp.2018.04.005

Petrović D, Seke M, Labudović-Borović M, Jović DS, Borišev I, Srđenović BU, Rakočević ZL, Pavlović VB, Đorđević AN. Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats. in Experimental and Molecular Pathology. 2018;104(3):199-211.
doi:10.1016/j.yexmp.2018.04.005 .

Petrović, Danijela, Seke, Mariana, Labudović-Borović, Milica, Jović, Danica S., Borišev, Ivana, Srđenović, Branislava U., Rakočević, Zlatko Lj., Pavlović, Vladimir B., Đorđević, Aleksandar N., "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats" in Experimental and Molecular Pathology, 104, no. 3 (2018):199-211,
https://doi.org/10.1016/j.yexmp.2018.04.005 . .

TY  - JOUR
AU  - Borišev, Ivana
AU  - Mrđanović, Jasminka Ž.
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Jović, Danica S.
AU  - Srđenović, Branislava U.
AU  - Latinović, Nataša
AU  - Đorđević, Aleksandar N.
PY  - 2018
UR  - http://stacks.iop.org/0957-4484/29/i=33/a=332002?key=crossref.4804877570e2609bf6333877ee495ab3
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7751
AB  - Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.
T2  - Nanotechnology
T1  - Nanoformulations of doxorubicin: How far have we come and where do we go from here?
VL  - 29
IS  - 33
SP  - 332002
DO  - 10.1088/1361-6528/aac7dd
ER  - 

@article{
author = "Borišev, Ivana and Mrđanović, Jasminka Ž. and Petrović, Danijela and Seke, Mariana and Jović, Danica S. and Srđenović, Branislava U. and Latinović, Nataša and Đorđević, Aleksandar N.",
year = "2018",
abstract = "Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.",
journal = "Nanotechnology",
title = "Nanoformulations of doxorubicin: How far have we come and where do we go from here?",
volume = "29",
number = "33",
pages = "332002",
doi = "10.1088/1361-6528/aac7dd"
}

Borišev, I., Mrđanović, J. Ž., Petrović, D., Seke, M., Jović, D. S., Srđenović, B. U., Latinović, N.,& Đorđević, A. N.. (2018). Nanoformulations of doxorubicin: How far have we come and where do we go from here?. in Nanotechnology, 29(33), 332002.
https://doi.org/10.1088/1361-6528/aac7dd

Borišev I, Mrđanović JŽ, Petrović D, Seke M, Jović DS, Srđenović BU, Latinović N, Đorđević AN. Nanoformulations of doxorubicin: How far have we come and where do we go from here?. in Nanotechnology. 2018;29(33):332002.
doi:10.1088/1361-6528/aac7dd .

Borišev, Ivana, Mrđanović, Jasminka Ž., Petrović, Danijela, Seke, Mariana, Jović, Danica S., Srđenović, Branislava U., Latinović, Nataša, Đorđević, Aleksandar N., "Nanoformulations of doxorubicin: How far have we come and where do we go from here?" in Nanotechnology, 29, no. 33 (2018):332002,
https://doi.org/10.1088/1361-6528/aac7dd . .

TY  - CONF
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Labudović-Borović, Milica
AU  - Jović, Danica S.
AU  - Borišev, Ivana
AU  - Kanacki, Zdenko
AU  - Zikić, Dragan
AU  - Đorđević, Aleksandar N.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7182
AB  - Background: Doxorubicin is a first line cancer chemotherapeutic. Unfortunately, its clinical use is limited by its cardiotoxicity. It is known that iron overload aggravates anthracycline toxicity. Fullerenol is a 1 nm size molecule and in aqueous solutions is in the form of polyanionic nanoparticles, which enables them to serve as a good carrier of positively charged ions such as Fe2+. Fullerenol’s antioxidant activity through scavenging free radicals has already been proved in different biological systems.
Methods: The aim of our study was to investigate the effects of the fullerenol/iron nanocomposite as a pretreatment to doxorubicin on the rat’s heart in comparison to doxorubicin alone. After the 24h-treatment, adult male Wistar rats were sacrificed and hearts were collected for ultrastructural and qRT-PCR analysis. Considering the ability of doxorubicin to induce oxidative stress, and the fullerenol’s capability to mitigate it, we had chosen to monitor gene expression of enzymes involved in antioxidant defense.
Results: Ultrastructural study revealed that in the group pretreated with the nanocomposite prior to doxorubicin application cardiomyocytes were with preserved morphology and the structure of intercalated discs. On the other hand, the heart tissues of animals treated with doxorubicin alone were significantly more damaged. Intensive interstitial edema was observed, as well as vacuolization of cardiomyocytes, hypercontraction of sarcomeres, mitochondria of irregular shapes. qRT-PCR results have shown that neither treatment with doxorubicin alone nor the pretreatment with the nanocomposite did cause significant increase in mRNA levels of catalase and superoxide dismutase.
Conclusions: Our results indicate that the fullerenol/iron nanocomposite applied as pretreatment to doxorubicin induces less damage to the hearth tissue in comparison to doxorubicin alone.
C3  - Annals of Oncology
T1  - Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity
VL  - 28
IS  - Supplement 5
DO  - 10.1093/annonc/mdx390.057
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7182
ER  - 

@conference{
author = "Seke, Mariana and Petrović, Danijela and Labudović-Borović, Milica and Jović, Danica S. and Borišev, Ivana and Kanacki, Zdenko and Zikić, Dragan and Đorđević, Aleksandar N.",
year = "2017",
abstract = "Background: Doxorubicin is a first line cancer chemotherapeutic. Unfortunately, its clinical use is limited by its cardiotoxicity. It is known that iron overload aggravates anthracycline toxicity. Fullerenol is a 1 nm size molecule and in aqueous solutions is in the form of polyanionic nanoparticles, which enables them to serve as a good carrier of positively charged ions such as Fe2+. Fullerenol’s antioxidant activity through scavenging free radicals has already been proved in different biological systems.
Methods: The aim of our study was to investigate the effects of the fullerenol/iron nanocomposite as a pretreatment to doxorubicin on the rat’s heart in comparison to doxorubicin alone. After the 24h-treatment, adult male Wistar rats were sacrificed and hearts were collected for ultrastructural and qRT-PCR analysis. Considering the ability of doxorubicin to induce oxidative stress, and the fullerenol’s capability to mitigate it, we had chosen to monitor gene expression of enzymes involved in antioxidant defense.
Results: Ultrastructural study revealed that in the group pretreated with the nanocomposite prior to doxorubicin application cardiomyocytes were with preserved morphology and the structure of intercalated discs. On the other hand, the heart tissues of animals treated with doxorubicin alone were significantly more damaged. Intensive interstitial edema was observed, as well as vacuolization of cardiomyocytes, hypercontraction of sarcomeres, mitochondria of irregular shapes. qRT-PCR results have shown that neither treatment with doxorubicin alone nor the pretreatment with the nanocomposite did cause significant increase in mRNA levels of catalase and superoxide dismutase.
Conclusions: Our results indicate that the fullerenol/iron nanocomposite applied as pretreatment to doxorubicin induces less damage to the hearth tissue in comparison to doxorubicin alone.",
journal = "Annals of Oncology",
title = "Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity",
volume = "28",
number = "Supplement 5",
doi = "10.1093/annonc/mdx390.057",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7182"
}

Seke, M., Petrović, D., Labudović-Borović, M., Jović, D. S., Borišev, I., Kanacki, Z., Zikić, D.,& Đorđević, A. N.. (2017). Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity. in Annals of Oncology, 28(Supplement 5).
https://doi.org/10.1093/annonc/mdx390.057
https://hdl.handle.net/21.15107/rcub_vinar_7182

Seke M, Petrović D, Labudović-Borović M, Jović DS, Borišev I, Kanacki Z, Zikić D, Đorđević AN. Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity. in Annals of Oncology. 2017;28(Supplement 5).
doi:10.1093/annonc/mdx390.057
https://hdl.handle.net/21.15107/rcub_vinar_7182 .

Seke, Mariana, Petrović, Danijela, Labudović-Borović, Milica, Jović, Danica S., Borišev, Ivana, Kanacki, Zdenko, Zikić, Dragan, Đorđević, Aleksandar N., "Fullerenol/iron nanocomposite modulates doxorubicin-induced cardiotoxicity" in Annals of Oncology, 28, no. Supplement 5 (2017),
https://doi.org/10.1093/annonc/mdx390.057 .,
https://hdl.handle.net/21.15107/rcub_vinar_7182 .

TY  - JOUR
AU  - Seke, Mariana
AU  - Markelić, Milica
AU  - Morina, Arian
AU  - Jović, Danica S.
AU  - Korać, Aleksandra
AU  - Miličić, Dragana
AU  - Đorđević, Aleksandar N.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1609
AB  - Adsorption of non-polar compounds by suspended fullerene nanoaggregates (nC(60)) may enhance their toxicity and affect the fate, transformation, and transport of non-polar compounds in the environment. The potential of stable fullerene nanoaggregates as contaminant carriers in aqueous systems and the influence of chloromethanes (trichloromethane and dichloromethane) were studied on the midgut epithelial cells of Daphnia magna by light and electron microscopy. The size and shape of fullerene nanoaggregates were observed and measured using dynamic light scattering, transmission electron microscopy, and low vacuum scanning electron microscopy. The nC(60) in suspension appeared as a bulk of aggregates of irregular shape with a surface consisting of small clumps 20-30 nm in diameter. The presence of nC(60) aggregates was confirmed in midgut lumen and epithelial cells of D. magna. After in vivo acute exposure to chloromethane, light and electron microscopy revealed an extensive cytoplasmic vacuolization with disruption and loss of specific structures of D. magna midgut epithelium (mitochondria, endoplasmic reticulum, microvilli, peritrophic membrane) and increased appearance of necrotic cells. The degree of observed changes depended on the type of treatment: trichloromethane (TCM) induced the most notable changes, whereas fullerene nanoaggregates alone had no negative effects. Transmission electron microscopy also indicated increased lysosomal degradation and severe peroxidative damages of enterocyte mitochondria following combined exposure to chloromethane and fullerene nanoaggregates. In conclusion, the adsorption of chloromethane by fullerene nanoaggregates enhances their toxicity and induces peroxidative mitochondrial damage in midgut enterocytes.
T2  - Protoplasma
T1  - Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells
VL  - 254
IS  - 4
SP  - 1607
EP  - 1616
DO  - 10.1007/s00709-016-1049-9
ER  - 

@article{
author = "Seke, Mariana and Markelić, Milica and Morina, Arian and Jović, Danica S. and Korać, Aleksandra and Miličić, Dragana and Đorđević, Aleksandar N.",
year = "2017",
abstract = "Adsorption of non-polar compounds by suspended fullerene nanoaggregates (nC(60)) may enhance their toxicity and affect the fate, transformation, and transport of non-polar compounds in the environment. The potential of stable fullerene nanoaggregates as contaminant carriers in aqueous systems and the influence of chloromethanes (trichloromethane and dichloromethane) were studied on the midgut epithelial cells of Daphnia magna by light and electron microscopy. The size and shape of fullerene nanoaggregates were observed and measured using dynamic light scattering, transmission electron microscopy, and low vacuum scanning electron microscopy. The nC(60) in suspension appeared as a bulk of aggregates of irregular shape with a surface consisting of small clumps 20-30 nm in diameter. The presence of nC(60) aggregates was confirmed in midgut lumen and epithelial cells of D. magna. After in vivo acute exposure to chloromethane, light and electron microscopy revealed an extensive cytoplasmic vacuolization with disruption and loss of specific structures of D. magna midgut epithelium (mitochondria, endoplasmic reticulum, microvilli, peritrophic membrane) and increased appearance of necrotic cells. The degree of observed changes depended on the type of treatment: trichloromethane (TCM) induced the most notable changes, whereas fullerene nanoaggregates alone had no negative effects. Transmission electron microscopy also indicated increased lysosomal degradation and severe peroxidative damages of enterocyte mitochondria following combined exposure to chloromethane and fullerene nanoaggregates. In conclusion, the adsorption of chloromethane by fullerene nanoaggregates enhances their toxicity and induces peroxidative mitochondrial damage in midgut enterocytes.",
journal = "Protoplasma",
title = "Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells",
volume = "254",
number = "4",
pages = "1607-1616",
doi = "10.1007/s00709-016-1049-9"
}

Seke, M., Markelić, M., Morina, A., Jović, D. S., Korać, A., Miličić, D.,& Đorđević, A. N.. (2017). Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells. in Protoplasma, 254(4), 1607-1616.
https://doi.org/10.1007/s00709-016-1049-9

Seke M, Markelić M, Morina A, Jović DS, Korać A, Miličić D, Đorđević AN. Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells. in Protoplasma. 2017;254(4):1607-1616.
doi:10.1007/s00709-016-1049-9 .

Seke, Mariana, Markelić, Milica, Morina, Arian, Jović, Danica S., Korać, Aleksandra, Miličić, Dragana, Đorđević, Aleksandar N., "Synergistic mitotoxicity of chloromethanes and fullerene C-60 nanoaggregates in Daphnia magna midgut epithelial cells" in Protoplasma, 254, no. 4 (2017):1607-1616,
https://doi.org/10.1007/s00709-016-1049-9 . .

TY  - JOUR
AU  - Jović, Danica S.
AU  - Seke, Mariana
AU  - Đorđević, Aleksandar N.
AU  - Mrđanović, Jasminka Ž.
AU  - Aleksić, Lidija D.
AU  - Bogdanović, Gordana M.
AU  - Pavić, Aleksandar B.
AU  - Plavec, Janez
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1042
AB  - Doxorubicin is a very potent chemotherapeutic drug, however its side effects limit its clinical use. The aim of this research was to investigate the properties of a fullerenol/doxorubicin nanocomposite, its potentially cytotoxic and genotoxic effects on malignant cell lines, as well as its toxicity towards zebra fish embryos. Chromatographic, NMR and mass spectral analysis of the nanocomposite imply that interactions between doxorubicin and fullerenol are non-covalent bonds. The stability of the nanocomposite was confirmed by the use of atomic force microscopy, dynamic light scattering and transmission electron microscopy. The nanocomposite, compared to the free doxorubicin at equivalent concentrations, significantly decreased the viability of MCF-7 and MDA-MB-231 cells. The flow cytometry results indicated that doxorubicin-loaded fullerenol could remarkably increase the uptake of doxorubicin suggesting that fullerenol might be a promising intracellular targeting carrier for the efficient delivery of antitumor drugs into tumor cells. The nanocomposite also affected cell cycle distribution. A genotoxicity test showed that the nanocomposite at all examined concentrations on MCF-7 and at lower concentrations on MDA-MB-231 cells caused DNA damage. Consequently, cell proliferation was notably reduced when compared with controls. Results of the zebrafish embryotoxicity assay showed a decreased overall toxicity, particularly cardiotoxicity and increased safety of the nanocomposite in comparison to doxorubicin alone, as manifested by a higher survival of embryos and less pericardial edema.
T2  - RSC Advances
T1  - Fullerenol nanoparticles as a new delivery system for doxorubicin
VL  - 6
IS  - 45
SP  - 38563
EP  - 38578
DO  - 10.1039/c6ra03879d
ER  - 

@article{
author = "Jović, Danica S. and Seke, Mariana and Đorđević, Aleksandar N. and Mrđanović, Jasminka Ž. and Aleksić, Lidija D. and Bogdanović, Gordana M. and Pavić, Aleksandar B. and Plavec, Janez",
year = "2016",
abstract = "Doxorubicin is a very potent chemotherapeutic drug, however its side effects limit its clinical use. The aim of this research was to investigate the properties of a fullerenol/doxorubicin nanocomposite, its potentially cytotoxic and genotoxic effects on malignant cell lines, as well as its toxicity towards zebra fish embryos. Chromatographic, NMR and mass spectral analysis of the nanocomposite imply that interactions between doxorubicin and fullerenol are non-covalent bonds. The stability of the nanocomposite was confirmed by the use of atomic force microscopy, dynamic light scattering and transmission electron microscopy. The nanocomposite, compared to the free doxorubicin at equivalent concentrations, significantly decreased the viability of MCF-7 and MDA-MB-231 cells. The flow cytometry results indicated that doxorubicin-loaded fullerenol could remarkably increase the uptake of doxorubicin suggesting that fullerenol might be a promising intracellular targeting carrier for the efficient delivery of antitumor drugs into tumor cells. The nanocomposite also affected cell cycle distribution. A genotoxicity test showed that the nanocomposite at all examined concentrations on MCF-7 and at lower concentrations on MDA-MB-231 cells caused DNA damage. Consequently, cell proliferation was notably reduced when compared with controls. Results of the zebrafish embryotoxicity assay showed a decreased overall toxicity, particularly cardiotoxicity and increased safety of the nanocomposite in comparison to doxorubicin alone, as manifested by a higher survival of embryos and less pericardial edema.",
journal = "RSC Advances",
title = "Fullerenol nanoparticles as a new delivery system for doxorubicin",
volume = "6",
number = "45",
pages = "38563-38578",
doi = "10.1039/c6ra03879d"
}

Jović, D. S., Seke, M., Đorđević, A. N., Mrđanović, J. Ž., Aleksić, L. D., Bogdanović, G. M., Pavić, A. B.,& Plavec, J.. (2016). Fullerenol nanoparticles as a new delivery system for doxorubicin. in RSC Advances, 6(45), 38563-38578.
https://doi.org/10.1039/c6ra03879d

Jović DS, Seke M, Đorđević AN, Mrđanović JŽ, Aleksić LD, Bogdanović GM, Pavić AB, Plavec J. Fullerenol nanoparticles as a new delivery system for doxorubicin. in RSC Advances. 2016;6(45):38563-38578.
doi:10.1039/c6ra03879d .

Jović, Danica S., Seke, Mariana, Đorđević, Aleksandar N., Mrđanović, Jasminka Ž., Aleksić, Lidija D., Bogdanović, Gordana M., Pavić, Aleksandar B., Plavec, Janez, "Fullerenol nanoparticles as a new delivery system for doxorubicin" in RSC Advances, 6, no. 45 (2016):38563-38578,
https://doi.org/10.1039/c6ra03879d . .

TY  - JOUR
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Đorđević, Aleksandar N.
AU  - Jović, Danica S.
AU  - Labudović-Borović, Milica
AU  - Kanački, Zdenko
AU  - Janković, Milan
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1306
AB  - Fullerenol (C-60(OH)(24)) is present in aqueous solutions in the form of polyanion nanoparticles with particles size distribution within the range from 15 to 42 nm. In this research it is assumed that these features could enable fullerenol nanoparticles (FNPs) to bind positively charged molecules like doxorubicin (DOX) and serve as drug carriers. Considering this, fullerenol/doxorubicin nanocomposite (FNP/DOX) is formed and characterized by ultra-performance liquid chromatography tandem mass spectrometry, dynamic light scattering, atomic force microscopy and transmission electron microscopy. Measurements have shown that DOX did not significantly affect particle size (23 nm). It is also assumed that FNP/DOX could reduce the acute cardiotoxic effects of DOX in vivo (Wistar rats treated i.p.). In this study, quantitative real time polymerase chain reaction results have shown that treatment with DOX alone caused significant increase in mRNA levels of catalase (p LT 0.05) enzyme indicating the presence of oxidative stress. This effect is significantly reduced by the treatment with FNP/DOX (p LT 0.05). Furthermore, mRNA levels of antiapoptotic enzyme (Bcl-2) are significantly increased (p LT 0.05) in all treated groups, particularly where FNP/DOX was applied, suggesting cell resistance to apoptosis. Moreover, ultrastructural analysis has shown the absence of myelin figures within the mitochondria in the heart tissue with FNP/DOX treatment, indicating reduction of oxidative stress. Hence, our results have implied that FNP/DOX is generally less harmful to the heart compared to DOX.
T2  - Nanotechnology
T1  - Fullerenol/doxorubicin nanocomposite mitigates acute oxidative stress and modulates apoptosis in myocardial tissue
VL  - 27
IS  - 48
DO  - 10.1088/0957-4484/27/48/485101
ER  - 

@article{
author = "Seke, Mariana and Petrović, Danijela and Đorđević, Aleksandar N. and Jović, Danica S. and Labudović-Borović, Milica and Kanački, Zdenko and Janković, Milan",
year = "2016",
abstract = "Fullerenol (C-60(OH)(24)) is present in aqueous solutions in the form of polyanion nanoparticles with particles size distribution within the range from 15 to 42 nm. In this research it is assumed that these features could enable fullerenol nanoparticles (FNPs) to bind positively charged molecules like doxorubicin (DOX) and serve as drug carriers. Considering this, fullerenol/doxorubicin nanocomposite (FNP/DOX) is formed and characterized by ultra-performance liquid chromatography tandem mass spectrometry, dynamic light scattering, atomic force microscopy and transmission electron microscopy. Measurements have shown that DOX did not significantly affect particle size (23 nm). It is also assumed that FNP/DOX could reduce the acute cardiotoxic effects of DOX in vivo (Wistar rats treated i.p.). In this study, quantitative real time polymerase chain reaction results have shown that treatment with DOX alone caused significant increase in mRNA levels of catalase (p LT 0.05) enzyme indicating the presence of oxidative stress. This effect is significantly reduced by the treatment with FNP/DOX (p LT 0.05). Furthermore, mRNA levels of antiapoptotic enzyme (Bcl-2) are significantly increased (p LT 0.05) in all treated groups, particularly where FNP/DOX was applied, suggesting cell resistance to apoptosis. Moreover, ultrastructural analysis has shown the absence of myelin figures within the mitochondria in the heart tissue with FNP/DOX treatment, indicating reduction of oxidative stress. Hence, our results have implied that FNP/DOX is generally less harmful to the heart compared to DOX.",
journal = "Nanotechnology",
title = "Fullerenol/doxorubicin nanocomposite mitigates acute oxidative stress and modulates apoptosis in myocardial tissue",
volume = "27",
number = "48",
doi = "10.1088/0957-4484/27/48/485101"
}

Seke, M., Petrović, D., Đorđević, A. N., Jović, D. S., Labudović-Borović, M., Kanački, Z.,& Janković, M.. (2016). Fullerenol/doxorubicin nanocomposite mitigates acute oxidative stress and modulates apoptosis in myocardial tissue. in Nanotechnology, 27(48).
https://doi.org/10.1088/0957-4484/27/48/485101

Seke M, Petrović D, Đorđević AN, Jović DS, Labudović-Borović M, Kanački Z, Janković M. Fullerenol/doxorubicin nanocomposite mitigates acute oxidative stress and modulates apoptosis in myocardial tissue. in Nanotechnology. 2016;27(48).
doi:10.1088/0957-4484/27/48/485101 .

Seke, Mariana, Petrović, Danijela, Đorđević, Aleksandar N., Jović, Danica S., Labudović-Borović, Milica, Kanački, Zdenko, Janković, Milan, "Fullerenol/doxorubicin nanocomposite mitigates acute oxidative stress and modulates apoptosis in myocardial tissue" in Nanotechnology, 27, no. 48 (2016),
https://doi.org/10.1088/0957-4484/27/48/485101 . .

TY  - CONF
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Labudović-Borović, Milica
AU  - Jović, Danica S.
AU  - Srđenović, Branislava U.
AU  - Kanacki, Zdenko
AU  - Zikić, Dragan
AU  - Đorđević, Aleksandar N.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7081
C3  - FEBS Journal
T1  - Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats
VL  - 282
SP  - 242
EP  - 242
DO  - 10.1111/febs.13339
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7081
ER  - 

@conference{
author = "Seke, Mariana and Petrović, Danijela and Labudović-Borović, Milica and Jović, Danica S. and Srđenović, Branislava U. and Kanacki, Zdenko and Zikić, Dragan and Đorđević, Aleksandar N.",
year = "2015",
journal = "FEBS Journal",
title = "Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats",
volume = "282",
pages = "242-242",
doi = "10.1111/febs.13339",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7081"
}

Seke, M., Petrović, D., Labudović-Borović, M., Jović, D. S., Srđenović, B. U., Kanacki, Z., Zikić, D.,& Đorđević, A. N.. (2015). Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats. in FEBS Journal, 282, 242-242.
https://doi.org/10.1111/febs.13339
https://hdl.handle.net/21.15107/rcub_vinar_7081

Seke M, Petrović D, Labudović-Borović M, Jović DS, Srđenović BU, Kanacki Z, Zikić D, Đorđević AN. Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats. in FEBS Journal. 2015;282:242-242.
doi:10.1111/febs.13339
https://hdl.handle.net/21.15107/rcub_vinar_7081 .

Seke, Mariana, Petrović, Danijela, Labudović-Borović, Milica, Jović, Danica S., Srđenović, Branislava U., Kanacki, Zdenko, Zikić, Dragan, Đorđević, Aleksandar N., "Effects of a fullerenol/doxorubicin nanocomposite on the heart tissue of healthy rats" in FEBS Journal, 282 (2015):242-242,
https://doi.org/10.1111/febs.13339 .,
https://hdl.handle.net/21.15107/rcub_vinar_7081 .

TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Ignjatović, Nenad L.
AU  - Seke, Mariana
AU  - Jović, Danica S.
AU  - Uskoković, Dragan
AU  - Rakočević, Zlatko Lj.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/213
AB  - Fullerenols are polyhydroxylated, water soluble derivatives of fullerene C-60, with potential application in medicine as diagnostic agents, antioxidants or nano drug carriers. This paper describes synthesis and physical characterization of a new nanocomposite hydroxyapatite/fullerenol. Surface of the nanocomposite hydroxyapatite/fullerenol is inhomogeneous with the diameter of the particles in the range from 100 nm to 350 nm. The zeta potential of this nanocomposite is ten times lower when compared to hydroxyapatite. Surface phosphate groups of hydroxyapatite are prone to forming hydrogen bonds, when in close contact with hydroxyl groups, which could lead to formation of hydrogen bonds between hydroxyapatite and hydroxyl groups of fullerenol. The surface of hydroxyapatite particles (-2.5 mV) was modified by fullerenol particles, as confirmed by the obtained zeta potential value of the nanocomposite biomaterial hydroxyapatite/fullerenol (-25.0 mV).
T2  - Journal of Nanoscience and Nanotechnology
T1  - Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites
VL  - 15
IS  - 2
SP  - 1538
EP  - 1542
DO  - 10.1166/jnn.2015.8671
ER  - 

@article{
author = "Đorđević, Aleksandar N. and Ignjatović, Nenad L. and Seke, Mariana and Jović, Danica S. and Uskoković, Dragan and Rakočević, Zlatko Lj.",
year = "2015",
abstract = "Fullerenols are polyhydroxylated, water soluble derivatives of fullerene C-60, with potential application in medicine as diagnostic agents, antioxidants or nano drug carriers. This paper describes synthesis and physical characterization of a new nanocomposite hydroxyapatite/fullerenol. Surface of the nanocomposite hydroxyapatite/fullerenol is inhomogeneous with the diameter of the particles in the range from 100 nm to 350 nm. The zeta potential of this nanocomposite is ten times lower when compared to hydroxyapatite. Surface phosphate groups of hydroxyapatite are prone to forming hydrogen bonds, when in close contact with hydroxyl groups, which could lead to formation of hydrogen bonds between hydroxyapatite and hydroxyl groups of fullerenol. The surface of hydroxyapatite particles (-2.5 mV) was modified by fullerenol particles, as confirmed by the obtained zeta potential value of the nanocomposite biomaterial hydroxyapatite/fullerenol (-25.0 mV).",
journal = "Journal of Nanoscience and Nanotechnology",
title = "Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites",
volume = "15",
number = "2",
pages = "1538-1542",
doi = "10.1166/jnn.2015.8671"
}

Đorđević, A. N., Ignjatović, N. L., Seke, M., Jović, D. S., Uskoković, D.,& Rakočević, Z. Lj.. (2015). Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites. in Journal of Nanoscience and Nanotechnology, 15(2), 1538-1542.
https://doi.org/10.1166/jnn.2015.8671

Đorđević AN, Ignjatović NL, Seke M, Jović DS, Uskoković D, Rakočević ZL. Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites. in Journal of Nanoscience and Nanotechnology. 2015;15(2):1538-1542.
doi:10.1166/jnn.2015.8671 .

Đorđević, Aleksandar N., Ignjatović, Nenad L., Seke, Mariana, Jović, Danica S., Uskoković, Dragan, Rakočević, Zlatko Lj., "Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites" in Journal of Nanoscience and Nanotechnology, 15, no. 2 (2015):1538-1542,
https://doi.org/10.1166/jnn.2015.8671 . .

TY  - JOUR
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Srđenović, Branislava U.
AU  - Đorđević, Aleksandar N.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/698
AB  - Fullerenes are molecules that, due to their unique structure, have very specific chemical properties which offer them very wide array of applications in nanomedicine. The most prominent are protection from radiation-induced injury, neuroprotection, drug and gene delivery, anticancer therapy, adjuvant within different treatments, photosensitizing, sonosensitizing, bone reparation, and biosensing. However, it is of crucial importance to be elucidated how fullerenes immunomodulate human system of defense. In addition, the most current research, merging immunology and nanomedicine, results in development of nanovaccines, which may represent the milestone of future treatment of diseases.
T2  - Journal of Nanomaterials
T1  - Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System
DO  - 10.1155/2015/565638
ER  - 

@article{
author = "Petrović, Danijela and Seke, Mariana and Srđenović, Branislava U. and Đorđević, Aleksandar N.",
year = "2015",
abstract = "Fullerenes are molecules that, due to their unique structure, have very specific chemical properties which offer them very wide array of applications in nanomedicine. The most prominent are protection from radiation-induced injury, neuroprotection, drug and gene delivery, anticancer therapy, adjuvant within different treatments, photosensitizing, sonosensitizing, bone reparation, and biosensing. However, it is of crucial importance to be elucidated how fullerenes immunomodulate human system of defense. In addition, the most current research, merging immunology and nanomedicine, results in development of nanovaccines, which may represent the milestone of future treatment of diseases.",
journal = "Journal of Nanomaterials",
title = "Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System",
doi = "10.1155/2015/565638"
}

Petrović, D., Seke, M., Srđenović, B. U.,& Đorđević, A. N.. (2015). Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System. in Journal of Nanomaterials.
https://doi.org/10.1155/2015/565638

Petrović D, Seke M, Srđenović BU, Đorđević AN. Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System. in Journal of Nanomaterials. 2015;.
doi:10.1155/2015/565638 .

Petrović, Danijela, Seke, Mariana, Srđenović, Branislava U., Đorđević, Aleksandar N., "Applications of Anti/Prooxidant Fullerenes in Nanomedicine along with Fullerenes Influence on the Immune System" in Journal of Nanomaterials (2015),
https://doi.org/10.1155/2015/565638 . .

TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Srđenović, Branislava U.
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Injac, Rade
AU  - Mrđanović, Jasminka Ž.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/699
AB  - This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.
T2  - Journal of Nanomaterials
T1  - Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles
DO  - 10.1155/2015/567073
ER  - 

@article{
author = "Đorđević, Aleksandar N. and Srđenović, Branislava U. and Seke, Mariana and Petrović, Danijela and Injac, Rade and Mrđanović, Jasminka Ž.",
year = "2015",
abstract = "This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.",
journal = "Journal of Nanomaterials",
title = "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles",
doi = "10.1155/2015/567073"
}

Đorđević, A. N., Srđenović, B. U., Seke, M., Petrović, D., Injac, R.,& Mrđanović, J. Ž.. (2015). Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles. in Journal of Nanomaterials.
https://doi.org/10.1155/2015/567073

Đorđević AN, Srđenović BU, Seke M, Petrović D, Injac R, Mrđanović JŽ. Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles. in Journal of Nanomaterials. 2015;.
doi:10.1155/2015/567073 .

Đorđević, Aleksandar N., Srđenović, Branislava U., Seke, Mariana, Petrović, Danijela, Injac, Rade, Mrđanović, Jasminka Ž., "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles" in Journal of Nanomaterials (2015),
https://doi.org/10.1155/2015/567073 . .

TY  - CHAP
AU  - Đorđević, Aleksandar N.
AU  - Injac, Rade
AU  - Jović, Danica
AU  - Mrđanović, Jasminka Ž.
AU  - Seke, Mariana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12696
AB  - The unique size-dependent properties of carbon nanomaterials (CNMs)- graphene, nanotubes (CNTs) and fullerenes- make them very attractive for diagnostic and therapeutic application. This chapter presents possible application of CNMs. Graphene with extraordinary chemical and physical properties has already revealed a great number of potential applications such as environmental toxic material removal, drug delivery, tissue engineering, and fl uorescence-based biomolecular sensing. The CNT derivatives have many interesting properties which make them potentially useful in a living system as biosensors, bioelectronic devices based on enzyme-nanotube or antibody-nanotube conjugates, chemotherapeutic agents, hyperthermia therapy and immunotherapy agents, agent in treatment of central nervous system disorders, and tissue engineering agent. Fullerene C60 derivatives have been used as: drug and gene delivery vectors, magnetic resonance imaging agents, radio protectors, antioxidants, HIV-1 protease inhibitors, antigenotoxic agents, and phototherapy agents. Fullerenols are polyhydroxylated derivatives of fullerene (C60(OH)n) with remarkable antioxidant, xenobiotic-protective, radioprotective, nanodrug and endohedral gadolinium carrier properties.
T2  - Advanced Carbon Materials and Technology
T1  - Bioimpact of Carbon Nanomaterials
SP  - 193
EP  - 271
DO  - 10.1002/9781118895399.ch6
ER  - 

@inbook{
author = "Đorđević, Aleksandar N. and Injac, Rade and Jović, Danica and Mrđanović, Jasminka Ž. and Seke, Mariana",
year = "2014",
abstract = "The unique size-dependent properties of carbon nanomaterials (CNMs)- graphene, nanotubes (CNTs) and fullerenes- make them very attractive for diagnostic and therapeutic application. This chapter presents possible application of CNMs. Graphene with extraordinary chemical and physical properties has already revealed a great number of potential applications such as environmental toxic material removal, drug delivery, tissue engineering, and fl uorescence-based biomolecular sensing. The CNT derivatives have many interesting properties which make them potentially useful in a living system as biosensors, bioelectronic devices based on enzyme-nanotube or antibody-nanotube conjugates, chemotherapeutic agents, hyperthermia therapy and immunotherapy agents, agent in treatment of central nervous system disorders, and tissue engineering agent. Fullerene C60 derivatives have been used as: drug and gene delivery vectors, magnetic resonance imaging agents, radio protectors, antioxidants, HIV-1 protease inhibitors, antigenotoxic agents, and phototherapy agents. Fullerenols are polyhydroxylated derivatives of fullerene (C60(OH)n) with remarkable antioxidant, xenobiotic-protective, radioprotective, nanodrug and endohedral gadolinium carrier properties.",
journal = "Advanced Carbon Materials and Technology",
booktitle = "Bioimpact of Carbon Nanomaterials",
pages = "193-271",
doi = "10.1002/9781118895399.ch6"
}

Đorđević, A. N., Injac, R., Jović, D., Mrđanović, J. Ž.,& Seke, M.. (2014). Bioimpact of Carbon Nanomaterials. in Advanced Carbon Materials and Technology, 193-271.
https://doi.org/10.1002/9781118895399.ch6

Đorđević AN, Injac R, Jović D, Mrđanović JŽ, Seke M. Bioimpact of Carbon Nanomaterials. in Advanced Carbon Materials and Technology. 2014;:193-271.
doi:10.1002/9781118895399.ch6 .

Đorđević, Aleksandar N., Injac, Rade, Jović, Danica, Mrđanović, Jasminka Ž., Seke, Mariana, "Bioimpact of Carbon Nanomaterials" in Advanced Carbon Materials and Technology (2014):193-271,
https://doi.org/10.1002/9781118895399.ch6 . .

TY  - JOUR
AU  - Labudović-Borović, Milica
AU  - Icevic, Ivana
AU  - Kanački, Zdenko
AU  - Zikic, Dragan
AU  - Seke, Mariana
AU  - Injac, Rade
AU  - Đorđević, Aleksandar N.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5924
AB  - Cardioprotective effects of fullerenol C-60(OH)(24) nanoparticles (FNP) were investigated in pigs after a single treatment with doxorubicin (DOX). Semithin and ultrathin sections of myocardial tissue routinely prepared for transmission electron microscopy were analyzed. Extensive intracellular damage was confirmed in cardiomyocytes of DOX-treated animals. By means of ultrastructural analysis, a certain degree of parenchymal degeneration was confirmed even in animals treated with FNP alone, including both the oral and the intraperitoneal application of the substance. The cardioprotective effects of FNP in animals previously treated with DOX were recognized to a certain extent, but were not fully confirmed at the ultrastructural level. Nevertheless, the myocardial morphology of DOX-treated animals improved after the admission of FNP. Irregular orientation of myofibrils, myofibrillar disruption, intracellular edema, and vacuolization were reduced, but not completely eliminated. Reduction of these cellular alterations was achieved if FNP was applied orally 6 h prior to DOX treatment in a dose of 18 mg/kg. However, numerous defects, including the inner mitochondrial membrane and the plasma membrane disruption of certain cells persisted. In FNP/DOX-treated animals, the presence of multinuclear cells with mitosis-like figures resembling metaphase or anaphase were observed, indicating that DOX and FNP could have a complex influence on the cell cycle of cardiomyocytes. Based on this experiment, further careful increase in dosage may be advised to enhance FNP-induced cardioprotection. These investigations should, however, always be combined with ultrastructural analysis. The FNP/DOX interaction is an excellent model for the investigation of cardiomyocyte cell death and cell cycle mechanisms.
T2  - Ultrastructural Pathology
T1  - Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study
VL  - 38
IS  - 2
SP  - 150
EP  - 163
DO  - 10.3109/01913123.2013.822045
ER  - 

@article{
author = "Labudović-Borović, Milica and Icevic, Ivana and Kanački, Zdenko and Zikic, Dragan and Seke, Mariana and Injac, Rade and Đorđević, Aleksandar N.",
year = "2014",
abstract = "Cardioprotective effects of fullerenol C-60(OH)(24) nanoparticles (FNP) were investigated in pigs after a single treatment with doxorubicin (DOX). Semithin and ultrathin sections of myocardial tissue routinely prepared for transmission electron microscopy were analyzed. Extensive intracellular damage was confirmed in cardiomyocytes of DOX-treated animals. By means of ultrastructural analysis, a certain degree of parenchymal degeneration was confirmed even in animals treated with FNP alone, including both the oral and the intraperitoneal application of the substance. The cardioprotective effects of FNP in animals previously treated with DOX were recognized to a certain extent, but were not fully confirmed at the ultrastructural level. Nevertheless, the myocardial morphology of DOX-treated animals improved after the admission of FNP. Irregular orientation of myofibrils, myofibrillar disruption, intracellular edema, and vacuolization were reduced, but not completely eliminated. Reduction of these cellular alterations was achieved if FNP was applied orally 6 h prior to DOX treatment in a dose of 18 mg/kg. However, numerous defects, including the inner mitochondrial membrane and the plasma membrane disruption of certain cells persisted. In FNP/DOX-treated animals, the presence of multinuclear cells with mitosis-like figures resembling metaphase or anaphase were observed, indicating that DOX and FNP could have a complex influence on the cell cycle of cardiomyocytes. Based on this experiment, further careful increase in dosage may be advised to enhance FNP-induced cardioprotection. These investigations should, however, always be combined with ultrastructural analysis. The FNP/DOX interaction is an excellent model for the investigation of cardiomyocyte cell death and cell cycle mechanisms.",
journal = "Ultrastructural Pathology",
title = "Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study",
volume = "38",
number = "2",
pages = "150-163",
doi = "10.3109/01913123.2013.822045"
}

Labudović-Borović, M., Icevic, I., Kanački, Z., Zikic, D., Seke, M., Injac, R.,& Đorđević, A. N.. (2014). Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study. in Ultrastructural Pathology, 38(2), 150-163.
https://doi.org/10.3109/01913123.2013.822045

Labudović-Borović M, Icevic I, Kanački Z, Zikic D, Seke M, Injac R, Đorđević AN. Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study. in Ultrastructural Pathology. 2014;38(2):150-163.
doi:10.3109/01913123.2013.822045 .

Labudović-Borović, Milica, Icevic, Ivana, Kanački, Zdenko, Zikic, Dragan, Seke, Mariana, Injac, Rade, Đorđević, Aleksandar N., "Effects of Fullerenol C-60(OH)(24) Nanoparticles on a Single-dose Doxorubicin-induced Cardiotoxicity in Pigs: An Ultrastructural Study" in Ultrastructural Pathology, 38, no. 2 (2014):150-163,
https://doi.org/10.3109/01913123.2013.822045 . .

TY  - JOUR
AU  - Slavic, Marija
AU  - Đorđević, Aleksandar N.
AU  - Radojicic, Ratko
AU  - Milovanović, Slobodan
AU  - Oreščanin-Dušić, Zorana S.
AU  - Rakočević, Zlatko Lj.
AU  - Spasić, Mihajlo
AU  - Blagojević, Duško P.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5496
AB  - Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.
T2  - Journal of Nanoparticle Research
T1  - Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction
VL  - 15
IS  - 5
DO  - 10.1007/s11051-013-1650-1
ER  - 

@article{
author = "Slavic, Marija and Đorđević, Aleksandar N. and Radojicic, Ratko and Milovanović, Slobodan and Oreščanin-Dušić, Zorana S. and Rakočević, Zlatko Lj. and Spasić, Mihajlo and Blagojević, Duško P.",
year = "2013",
abstract = "Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.",
journal = "Journal of Nanoparticle Research",
title = "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction",
volume = "15",
number = "5",
doi = "10.1007/s11051-013-1650-1"
}

Slavic, M., Đorđević, A. N., Radojicic, R., Milovanović, S., Oreščanin-Dušić, Z. S., Rakočević, Z. Lj., Spasić, M.,& Blagojević, D. P.. (2013). Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research, 15(5).
https://doi.org/10.1007/s11051-013-1650-1

Slavic M, Đorđević AN, Radojicic R, Milovanović S, Oreščanin-Dušić ZS, Rakočević ZL, Spasić M, Blagojević DP. Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research. 2013;15(5).
doi:10.1007/s11051-013-1650-1 .

Slavic, Marija, Đorđević, Aleksandar N., Radojicic, Ratko, Milovanović, Slobodan, Oreščanin-Dušić, Zorana S., Rakočević, Zlatko Lj., Spasić, Mihajlo, Blagojević, Duško P., "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction" in Journal of Nanoparticle Research, 15, no. 5 (2013),
https://doi.org/10.1007/s11051-013-1650-1 . .

TY  - JOUR
AU  - Cekić, Božidar Đ.
AU  - Ivanovski, Valentin N.
AU  - Đorđević, Aleksandar N.
AU  - Aleksić, Velimir
AU  - Tomić, Zorica
AU  - Bogdanović, Stefan
AU  - Umićević, Ana
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4927
AB  - The paper addresses the issue of health risk associated with the presence of chrysotile in the soil type ranker formed on massive serpentines occurring in the area of Bubanj Potok, a settlement located in the southern Belgrade environs, Serbia. Characterization of the ranker soil was conducted by scanning electron microscopy, X-ray diffraction, micro-Raman spectroscopy and transmission Fe-57 Mossbauer spectroscopy. Scanning electron microscopy figures showed regular shaped smectite (montmorillonite) particles, aggregates of chlorite, and elongated sheets of serpentines minerals antigorite. X-ray diffraction analysis confirmed the presence of detrital mineral quartz polymorph as well as minor amounts of other mineral species. Micro-Raman spectroscopy identified the presence of dominant minerals, such as montmorillonite, kaolinite, muscovite, gypsum, calcite, albite, amphiboles (hornblende/kaersutite) and orthoclase. Important polymorph silica modifications of quartz, olivine (forsterite), pyroxene (enstatite/ferrosilite, diopside/hedenbergite), and serpentine (antigorite/lizardite/chrysotile) were identified.
T2  - Nuclear technology and radiation protection
T1  - Mineral Characterization of Soil Type Ranker Formed on Serpentines Occurring in Southern Belgrade Environs Bubanj Potok
VL  - 27
IS  - 2
SP  - 131
EP  - 136
DO  - 10.2298/NTRP1202131C
ER  - 

@article{
author = "Cekić, Božidar Đ. and Ivanovski, Valentin N. and Đorđević, Aleksandar N. and Aleksić, Velimir and Tomić, Zorica and Bogdanović, Stefan and Umićević, Ana",
year = "2012",
abstract = "The paper addresses the issue of health risk associated with the presence of chrysotile in the soil type ranker formed on massive serpentines occurring in the area of Bubanj Potok, a settlement located in the southern Belgrade environs, Serbia. Characterization of the ranker soil was conducted by scanning electron microscopy, X-ray diffraction, micro-Raman spectroscopy and transmission Fe-57 Mossbauer spectroscopy. Scanning electron microscopy figures showed regular shaped smectite (montmorillonite) particles, aggregates of chlorite, and elongated sheets of serpentines minerals antigorite. X-ray diffraction analysis confirmed the presence of detrital mineral quartz polymorph as well as minor amounts of other mineral species. Micro-Raman spectroscopy identified the presence of dominant minerals, such as montmorillonite, kaolinite, muscovite, gypsum, calcite, albite, amphiboles (hornblende/kaersutite) and orthoclase. Important polymorph silica modifications of quartz, olivine (forsterite), pyroxene (enstatite/ferrosilite, diopside/hedenbergite), and serpentine (antigorite/lizardite/chrysotile) were identified.",
journal = "Nuclear technology and radiation protection",
title = "Mineral Characterization of Soil Type Ranker Formed on Serpentines Occurring in Southern Belgrade Environs Bubanj Potok",
volume = "27",
number = "2",
pages = "131-136",
doi = "10.2298/NTRP1202131C"
}

Cekić, B. Đ., Ivanovski, V. N., Đorđević, A. N., Aleksić, V., Tomić, Z., Bogdanović, S.,& Umićević, A.. (2012). Mineral Characterization of Soil Type Ranker Formed on Serpentines Occurring in Southern Belgrade Environs Bubanj Potok. in Nuclear technology and radiation protection, 27(2), 131-136.
https://doi.org/10.2298/NTRP1202131C

Cekić BĐ, Ivanovski VN, Đorđević AN, Aleksić V, Tomić Z, Bogdanović S, Umićević A. Mineral Characterization of Soil Type Ranker Formed on Serpentines Occurring in Southern Belgrade Environs Bubanj Potok. in Nuclear technology and radiation protection. 2012;27(2):131-136.
doi:10.2298/NTRP1202131C .

Cekić, Božidar Đ., Ivanovski, Valentin N., Đorđević, Aleksandar N., Aleksić, Velimir, Tomić, Zorica, Bogdanović, Stefan, Umićević, Ana, "Mineral Characterization of Soil Type Ranker Formed on Serpentines Occurring in Southern Belgrade Environs Bubanj Potok" in Nuclear technology and radiation protection, 27, no. 2 (2012):131-136,
https://doi.org/10.2298/NTRP1202131C . .

TY  - JOUR
AU  - Mrđanović, Jasminka Ž.
AU  - Solajic, Slavica V.
AU  - Bogdanović, Višnja V.
AU  - Đorđević, Aleksandar N.
AU  - Bogdanović, Gordana M.
AU  - Injac, Rade D.
AU  - Rakočević, Zlatko Lj.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4935
AB  - Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes
VL  - 7
IS  - 2
SP  - 673
EP  - 686
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4935
ER  - 

@article{
author = "Mrđanović, Jasminka Ž. and Solajic, Slavica V. and Bogdanović, Višnja V. and Đorđević, Aleksandar N. and Bogdanović, Gordana M. and Injac, Rade D. and Rakočević, Zlatko Lj.",
year = "2012",
abstract = "Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes",
volume = "7",
number = "2",
pages = "673-686",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4935"
}

Mrđanović, J. Ž., Solajic, S. V., Bogdanović, V. V., Đorđević, A. N., Bogdanović, G. M., Injac, R. D.,& Rakočević, Z. Lj.. (2012). Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. in Digest Journal of Nanomaterials and Biostructures, 7(2), 673-686.
https://hdl.handle.net/21.15107/rcub_vinar_4935

Mrđanović JŽ, Solajic SV, Bogdanović VV, Đorđević AN, Bogdanović GM, Injac RD, Rakočević ZL. Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. in Digest Journal of Nanomaterials and Biostructures. 2012;7(2):673-686.
https://hdl.handle.net/21.15107/rcub_vinar_4935 .

Mrđanović, Jasminka Ž., Solajic, Slavica V., Bogdanović, Višnja V., Đorđević, Aleksandar N., Bogdanović, Gordana M., Injac, Rade D., Rakočević, Zlatko Lj., "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes" in Digest Journal of Nanomaterials and Biostructures, 7, no. 2 (2012):673-686,
https://hdl.handle.net/21.15107/rcub_vinar_4935 .

TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Ajdinovic, B.
AU  - Dopudja, M.
AU  - Trajkovic, S.
AU  - Milovanović, Z.
AU  - Maksin, Tatjana N.
AU  - Nešković, Olivera M.
AU  - Bogdanović, Višnja V.
AU  - Trpkov, Đorđe
AU  - Cvetićanin, Jelena M.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4282
AB  - In this study we performed the dynamic and static scintigraphy of the domestic dog, using the newly synthesized radiopharmaceutical, [Tc-99m(CO)(3)(H2O)(3)]-C-60(OH)(22-24). In the current study, an advanced one-step method for the functionalization of fullerenol by Tc-99m is described. Optical properties of as-prepared samples and the mechanism responsible for the functionalization were investigated using UV-VIS and FTIR spectroscopy, respectively. Also, the presence of the Tc complex on fullerenol was confirmed by using the energy dispersive X-ray spectroscopy, HPLC and MALDI TOF techniques. This simple and effective method of producing a new radiopharmaceutical is of interest not only for its application in various areas of technology and biology, but also for investigating its potential use in radiation technology for nanoengineering of materials. With dynamic scintigraphy, performed during 30 minutes (120 frames, 15 sec per frame), we obtained ratios of heart, liver and spleen counts: 222/249/168; 178/320/217; 120/348/239 respectively. By static scintigraphy after 1 hour, we detected the activity in heart, liver, spleen and intestines. After 4 hours, the radiopharmaceutical activity was detected in salivary glands. The detection after 21 hours showed the activity in kidneys and urinary bladder, while the activity in intestines was absent. After 24 hours, we detected the activity in liver, spleen, kidneys and urinary bladder. Pharmacokinetic investigations performed in this study are of key interest for the further fullerenol in vivo research.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24)
VL  - 6
IS  - 1
SP  - 99
EP  - 106
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4282
ER  - 

@article{
author = "Đorđević, Aleksandar N. and Ajdinovic, B. and Dopudja, M. and Trajkovic, S. and Milovanović, Z. and Maksin, Tatjana N. and Nešković, Olivera M. and Bogdanović, Višnja V. and Trpkov, Đorđe and Cvetićanin, Jelena M.",
year = "2011",
abstract = "In this study we performed the dynamic and static scintigraphy of the domestic dog, using the newly synthesized radiopharmaceutical, [Tc-99m(CO)(3)(H2O)(3)]-C-60(OH)(22-24). In the current study, an advanced one-step method for the functionalization of fullerenol by Tc-99m is described. Optical properties of as-prepared samples and the mechanism responsible for the functionalization were investigated using UV-VIS and FTIR spectroscopy, respectively. Also, the presence of the Tc complex on fullerenol was confirmed by using the energy dispersive X-ray spectroscopy, HPLC and MALDI TOF techniques. This simple and effective method of producing a new radiopharmaceutical is of interest not only for its application in various areas of technology and biology, but also for investigating its potential use in radiation technology for nanoengineering of materials. With dynamic scintigraphy, performed during 30 minutes (120 frames, 15 sec per frame), we obtained ratios of heart, liver and spleen counts: 222/249/168; 178/320/217; 120/348/239 respectively. By static scintigraphy after 1 hour, we detected the activity in heart, liver, spleen and intestines. After 4 hours, the radiopharmaceutical activity was detected in salivary glands. The detection after 21 hours showed the activity in kidneys and urinary bladder, while the activity in intestines was absent. After 24 hours, we detected the activity in liver, spleen, kidneys and urinary bladder. Pharmacokinetic investigations performed in this study are of key interest for the further fullerenol in vivo research.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24)",
volume = "6",
number = "1",
pages = "99-106",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4282"
}

Đorđević, A. N., Ajdinovic, B., Dopudja, M., Trajkovic, S., Milovanović, Z., Maksin, T. N., Nešković, O. M., Bogdanović, V. V., Trpkov, Đ.,& Cvetićanin, J. M.. (2011). Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24). in Digest Journal of Nanomaterials and Biostructures, 6(1), 99-106.
https://hdl.handle.net/21.15107/rcub_vinar_4282

Đorđević AN, Ajdinovic B, Dopudja M, Trajkovic S, Milovanović Z, Maksin TN, Nešković OM, Bogdanović VV, Trpkov Đ, Cvetićanin JM. Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24). in Digest Journal of Nanomaterials and Biostructures. 2011;6(1):99-106.
https://hdl.handle.net/21.15107/rcub_vinar_4282 .

Đorđević, Aleksandar N., Ajdinovic, B., Dopudja, M., Trajkovic, S., Milovanović, Z., Maksin, Tatjana N., Nešković, Olivera M., Bogdanović, Višnja V., Trpkov, Đorđe, Cvetićanin, Jelena M., "Scintigraphy of the Domestic Dog Using [Tc-99m(Co)(3)(H2o)(3)]-C-60(Oh)(22-24)" in Digest Journal of Nanomaterials and Biostructures, 6, no. 1 (2011):99-106,
https://hdl.handle.net/21.15107/rcub_vinar_4282 .

TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Vojinović Miloradov, Mirjana B.
AU  - Petranović, Nadežda A.
AU  - Devečerski, Aleksandar
AU  - Lazar, Dušan V.
AU  - Ribar, Bela J.
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7760
AB  - In this paper the procedure for catalytical bromination of C60 with elementary bromine with FeBr3 as a catalyst is described In this procedures only one reaction product - C60 Br24 is obtained. The twenty four bromine atoms are symmetrically distributed over the C60 sphere, which was confirmed by thermogravi metric analysis. The yield of bromine derivative in this reaction is 98%.
T2  - Fullerene Science and Technology
T1  - Catalytic preparation and characterization of C60Br24
VL  - 6
IS  - 4
SP  - 689
EP  - 694
DO  - 10.1080/10641229809350229
ER  - 

@article{
author = "Đorđević, Aleksandar N. and Vojinović Miloradov, Mirjana B. and Petranović, Nadežda A. and Devečerski, Aleksandar and Lazar, Dušan V. and Ribar, Bela J.",
year = "1998",
abstract = "In this paper the procedure for catalytical bromination of C60 with elementary bromine with FeBr3 as a catalyst is described In this procedures only one reaction product - C60 Br24 is obtained. The twenty four bromine atoms are symmetrically distributed over the C60 sphere, which was confirmed by thermogravi metric analysis. The yield of bromine derivative in this reaction is 98%.",
journal = "Fullerene Science and Technology",
title = "Catalytic preparation and characterization of C60Br24",
volume = "6",
number = "4",
pages = "689-694",
doi = "10.1080/10641229809350229"
}

Đorđević, A. N., Vojinović Miloradov, M. B., Petranović, N. A., Devečerski, A., Lazar, D. V.,& Ribar, B. J.. (1998). Catalytic preparation and characterization of C60Br24. in Fullerene Science and Technology, 6(4), 689-694.
https://doi.org/10.1080/10641229809350229

Đorđević AN, Vojinović Miloradov MB, Petranović NA, Devečerski A, Lazar DV, Ribar BJ. Catalytic preparation and characterization of C60Br24. in Fullerene Science and Technology. 1998;6(4):689-694.
doi:10.1080/10641229809350229 .

Đorđević, Aleksandar N., Vojinović Miloradov, Mirjana B., Petranović, Nadežda A., Devečerski, Aleksandar, Lazar, Dušan V., Ribar, Bela J., "Catalytic preparation and characterization of C60Br24" in Fullerene Science and Technology, 6, no. 4 (1998):689-694,
https://doi.org/10.1080/10641229809350229 . .