TY  - CONF
AU  - Kožik, Bojana
AU  - Božović, Ana
AU  - Kokanov, Nikola
AU  - Mandušić, Vesna
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Stanojević, Boban
AU  - Todorović, Lidija
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12507
AB  - Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Identifying novel molecular parameters with prognostic value is of great clinical importance for a personalized therapeutic approach. Epigenetic changes have been proven to play an important role in cancer pathogenesis. Hypermethylation of the promoter region of p16INK4a gene has been shown to be a significant event in a number of cancer types. Several studies suggested that it might have a prognostic impact in ACC as well, however the data are relatively ambiguous.  According to the dataset from The Cancer Genome Atlas (TCGA) database, in cohort of 79 ACC patients, the analysis of the p16INK4a gene methylation showed that higher methylation was associated with shorter progression-free and overall survival. We evaluate the methylation status of p16INK4a in a preliminary cohort of 30 ACC patients by using the methylation-specific polymerase chain reaction (MSP) and aberrant methylation of p16INK4a was present in 66.7% (20/30) of cases. Our results indicate that epigenetic alteration of this gene is common event in ACC and may be important for pathogenesis of this tumor type. Although, we did not observed significant association between p16INK4a methylation status and clinico-pathological characteristics (age and gender, tumor size and weight, regional lymph node and distant metastasis), we will evaluate methylation status of this gene in another 30 ACC cases and compare it with methylation profile of adrenocortical adenoma patients, since inactivation of p16INK4a gene by promoter hypermethylation has been frequently reported as an early event in premalignant lesions in many tumor types.
PB  - Poland : The National Institute of Cardiology
C3  - The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
T1  - Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study
SP  - A17
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12507
ER  - 

@conference{
author = "Kožik, Bojana and Božović, Ana and Kokanov, Nikola and Mandušić, Vesna and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban and Todorović, Lidija",
year = "2022",
abstract = "Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Identifying novel molecular parameters with prognostic value is of great clinical importance for a personalized therapeutic approach. Epigenetic changes have been proven to play an important role in cancer pathogenesis. Hypermethylation of the promoter region of p16INK4a gene has been shown to be a significant event in a number of cancer types. Several studies suggested that it might have a prognostic impact in ACC as well, however the data are relatively ambiguous.  According to the dataset from The Cancer Genome Atlas (TCGA) database, in cohort of 79 ACC patients, the analysis of the p16INK4a gene methylation showed that higher methylation was associated with shorter progression-free and overall survival. We evaluate the methylation status of p16INK4a in a preliminary cohort of 30 ACC patients by using the methylation-specific polymerase chain reaction (MSP) and aberrant methylation of p16INK4a was present in 66.7% (20/30) of cases. Our results indicate that epigenetic alteration of this gene is common event in ACC and may be important for pathogenesis of this tumor type. Although, we did not observed significant association between p16INK4a methylation status and clinico-pathological characteristics (age and gender, tumor size and weight, regional lymph node and distant metastasis), we will evaluate methylation status of this gene in another 30 ACC cases and compare it with methylation profile of adrenocortical adenoma patients, since inactivation of p16INK4a gene by promoter hypermethylation has been frequently reported as an early event in premalignant lesions in many tumor types.",
publisher = "Poland : The National Institute of Cardiology",
journal = "The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts",
title = "Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study",
pages = "A17",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12507"
}

Kožik, B., Božović, A., Kokanov, N., Mandušić, V., Živaljević, V., Paunović, I., Stanojević, B.,& Todorović, L.. (2022). Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
Poland : The National Institute of Cardiology., A17.
https://hdl.handle.net/21.15107/rcub_vinar_12507

Kožik B, Božović A, Kokanov N, Mandušić V, Živaljević V, Paunović I, Stanojević B, Todorović L. Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts. 2022;:A17.
https://hdl.handle.net/21.15107/rcub_vinar_12507 .

Kožik, Bojana, Božović, Ana, Kokanov, Nikola, Mandušić, Vesna, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, Todorović, Lidija, "Methylation status of p16INK4a tumor-suppressor gene in adrenocortical carcinoma: preliminary study" in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts (2022):A17,
https://hdl.handle.net/21.15107/rcub_vinar_12507 .

TY  - CONF
AU  - Todorović, Lidija
AU  - Kožik, Bojana
AU  - Božović, Ana
AU  - Mandušić, Vesna
AU  - Stanojević, Boban
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12509
AB  - Adrenocortical tumors (ACTs) are heterogeneous neoplasms with incompletely understood pathogenesis. Correct differential diagnosis between adrenocortical adenoma (ACA) and localized adrenocortical carcinoma (ACC), as well as improved prognostic stratification of ACC patients, are of great clinical importance. Alterations in gene expression patterns have been found in adrenocortical neoplasms compared to normal tissue. In addition to having a role in tumorigenesis, distinct gene expression signatures may help to distinguish different ACT types. The combined expression patterns of PINK1, DLGAP5 and BUB1B have been suggested as malignancy and outcome predictors in previous studies. In order to validate their diagnostic/prognostic potential, we investigated the expression levels of these three genes and their association with clinico-pathological parameters in a cohort of 47 ACC and 15 ACA patients from Serbia. In addition, we analyzed the association of their expression levels with survival data in an independent ACC cohort of 79 patients from The Cancer Genome Atlas (TCGA) database. The results showed that high expression levels of BUB1B and DLGAP5, and low expression levels of PINK1 significantly associated with ACC. Moreover, combined expression of both DLGAP5 and BUB1B with PINK1 were significantly higher in localized ACC compared with ACA. The results from the TCGA cohort showed that expression alterations of these genes were strong predictors of disease-free and overall survival in ACC patients. These results are consistent with the previously reported results and confirm that the expression patterns of PINK1, DLGAP5 and BUB1B might have value as molecular predictors of malignancy and/or survival in ACC patients.
PB  - Poland : The National Institute of Cardiology
C3  - The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
T1  - Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors
SP  - A39
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12509
ER  - 

@conference{
author = "Todorović, Lidija and Kožik, Bojana and Božović, Ana and Mandušić, Vesna and Stanojević, Boban and Živaljević, Vladan and Paunović, Ivan",
year = "2022",
abstract = "Adrenocortical tumors (ACTs) are heterogeneous neoplasms with incompletely understood pathogenesis. Correct differential diagnosis between adrenocortical adenoma (ACA) and localized adrenocortical carcinoma (ACC), as well as improved prognostic stratification of ACC patients, are of great clinical importance. Alterations in gene expression patterns have been found in adrenocortical neoplasms compared to normal tissue. In addition to having a role in tumorigenesis, distinct gene expression signatures may help to distinguish different ACT types. The combined expression patterns of PINK1, DLGAP5 and BUB1B have been suggested as malignancy and outcome predictors in previous studies. In order to validate their diagnostic/prognostic potential, we investigated the expression levels of these three genes and their association with clinico-pathological parameters in a cohort of 47 ACC and 15 ACA patients from Serbia. In addition, we analyzed the association of their expression levels with survival data in an independent ACC cohort of 79 patients from The Cancer Genome Atlas (TCGA) database. The results showed that high expression levels of BUB1B and DLGAP5, and low expression levels of PINK1 significantly associated with ACC. Moreover, combined expression of both DLGAP5 and BUB1B with PINK1 were significantly higher in localized ACC compared with ACA. The results from the TCGA cohort showed that expression alterations of these genes were strong predictors of disease-free and overall survival in ACC patients. These results are consistent with the previously reported results and confirm that the expression patterns of PINK1, DLGAP5 and BUB1B might have value as molecular predictors of malignancy and/or survival in ACC patients.",
publisher = "Poland : The National Institute of Cardiology",
journal = "The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts",
title = "Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors",
pages = "A39",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12509"
}

Todorović, L., Kožik, B., Božović, A., Mandušić, V., Stanojević, B., Živaljević, V.,& Paunović, I.. (2022). Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts
Poland : The National Institute of Cardiology., A39.
https://hdl.handle.net/21.15107/rcub_vinar_12509

Todorović L, Kožik B, Božović A, Mandušić V, Stanojević B, Živaljević V, Paunović I. Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts. 2022;:A39.
https://hdl.handle.net/21.15107/rcub_vinar_12509 .

Todorović, Lidija, Kožik, Bojana, Božović, Ana, Mandušić, Vesna, Stanojević, Boban, Živaljević, Vladan, Paunović, Ivan, "Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors" in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts (2022):A39,
https://hdl.handle.net/21.15107/rcub_vinar_12509 .

TY  - CONF
AU  - Todorović, Lidija
AU  - Petrović, Nina
AU  - Mandušić, Vesna
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Stanojević, Boban
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12426
AB  - Although one of the rarest known malignancies, with an estimated prevalence of 0.005% of all cancers, parathyroid carcinoma (PC) represents a clinical and therapeutic challenge. The identification of novel diagnostic biomarkers able to preoperatively distinguish among different parathyroid neoplastic types is of great clinical importance. However, there is a lack of both experimental and bioinformatics data in this field. In the present study, we examined the expression levels of two microRNAs frequently implicated in cancer, miR-30a-3p and miR-92a-3p, in 10 PC and 10 parathyroid adenoma (PA) tissues using reverse transcription quantitative (RT-qPCR). In addition, we analyzed their association with clinical and histopathological parameters. For statistical analysis we used non-parametric tests – Mann–Whitney U test and Spearman’s correlation test. Furthermore, by using several online tools such as miRNet, miRror Suit, and DisGeNET we analyzed combinatorial target genes of the two miRs and investigated their potential roles in parathyroid carcinoma and adenoma. The expression levels of both miR-30a-3p and miR-92a-3p were upregulated in PC compared to PA (p= 0.017 and p=0.0015 respectively). A positive correlation between their expression levels was identified both in PC (p=0.025, r=0.697) and PA (p=0.008, r=0745), indicating their combined action. There were no significant associations between the expression levels of these two miRs and clinicopathological characteristics in the PC group. According to the in silico analysis, the two miRs share a number of target genes, predominantly included in gene expression, cell cycle regulation, and several signalling pathways such as WNT/β catenin, which was found to be frequently aberrant in PC. Although their role and diagnostic utility remain to be elucidated, the data here reported suggest that miR-30a-3p and miR-92a-3p might be involved in parathyroid cancer pathogenesis and that they might be candidates for differential diagnosis between parathyroid carcinoma and adenoma.
C3  - 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts
T1  - miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12426
ER  - 

@conference{
author = "Todorović, Lidija and Petrović, Nina and Mandušić, Vesna and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban",
year = "2022",
abstract = "Although one of the rarest known malignancies, with an estimated prevalence of 0.005% of all cancers, parathyroid carcinoma (PC) represents a clinical and therapeutic challenge. The identification of novel diagnostic biomarkers able to preoperatively distinguish among different parathyroid neoplastic types is of great clinical importance. However, there is a lack of both experimental and bioinformatics data in this field. In the present study, we examined the expression levels of two microRNAs frequently implicated in cancer, miR-30a-3p and miR-92a-3p, in 10 PC and 10 parathyroid adenoma (PA) tissues using reverse transcription quantitative (RT-qPCR). In addition, we analyzed their association with clinical and histopathological parameters. For statistical analysis we used non-parametric tests – Mann–Whitney U test and Spearman’s correlation test. Furthermore, by using several online tools such as miRNet, miRror Suit, and DisGeNET we analyzed combinatorial target genes of the two miRs and investigated their potential roles in parathyroid carcinoma and adenoma. The expression levels of both miR-30a-3p and miR-92a-3p were upregulated in PC compared to PA (p= 0.017 and p=0.0015 respectively). A positive correlation between their expression levels was identified both in PC (p=0.025, r=0.697) and PA (p=0.008, r=0745), indicating their combined action. There were no significant associations between the expression levels of these two miRs and clinicopathological characteristics in the PC group. According to the in silico analysis, the two miRs share a number of target genes, predominantly included in gene expression, cell cycle regulation, and several signalling pathways such as WNT/β catenin, which was found to be frequently aberrant in PC. Although their role and diagnostic utility remain to be elucidated, the data here reported suggest that miR-30a-3p and miR-92a-3p might be involved in parathyroid cancer pathogenesis and that they might be candidates for differential diagnosis between parathyroid carcinoma and adenoma.",
journal = "5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts",
title = "miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12426"
}

Todorović, L., Petrović, N., Mandušić, V., Živaljević, V., Paunović, I.,& Stanojević, B.. (2022). miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma. in 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts.
https://hdl.handle.net/21.15107/rcub_vinar_12426

Todorović L, Petrović N, Mandušić V, Živaljević V, Paunović I, Stanojević B. miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma. in 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts. 2022;.
https://hdl.handle.net/21.15107/rcub_vinar_12426 .

Todorović, Lidija, Petrović, Nina, Mandušić, Vesna, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, "miR-30a-3p and miR-92a-3p as potential diagnostic biomarkers in parathyroid carcinoma" in 5th Annual Meeting STRATAGEM: New diagnostic and therapeutic tools against multidrug resistant tumours : Book of abstracts (2022),
https://hdl.handle.net/21.15107/rcub_vinar_12426 .

TY  - JOUR
AU  - Todorović, Lidija
AU  - Mandušić, Vesna
AU  - Vučetić-Tadić, Biljana
AU  - Živaljević, Vladan
AU  - Paunović, Ivan
AU  - Stanojević, Boban
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9055
AB  - A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations.
T2  - Archives of Biological Sciences
T1  - Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics
VL  - 72
IS  - 1
SP  - 31
EP  - 36
DO  - 10.2298/ABS191004063T
ER  - 

@article{
author = "Todorović, Lidija and Mandušić, Vesna and Vučetić-Tadić, Biljana and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban",
year = "2020",
abstract = "A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations.",
journal = "Archives of Biological Sciences",
title = "Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics",
volume = "72",
number = "1",
pages = "31-36",
doi = "10.2298/ABS191004063T"
}

Todorović, L., Mandušić, V., Vučetić-Tadić, B., Živaljević, V., Paunović, I.,& Stanojević, B.. (2020). Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics. in Archives of Biological Sciences, 72(1), 31-36.
https://doi.org/10.2298/ABS191004063T

Todorović L, Mandušić V, Vučetić-Tadić B, Živaljević V, Paunović I, Stanojević B. Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics. in Archives of Biological Sciences. 2020;72(1):31-36.
doi:10.2298/ABS191004063T .

Todorović, Lidija, Mandušić, Vesna, Vučetić-Tadić, Biljana, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, "Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics" in Archives of Biological Sciences, 72, no. 1 (2020):31-36,
https://doi.org/10.2298/ABS191004063T . .

TY  - JOUR
AU  - Todorović, Lidija
AU  - Stanojević, Boban
AU  - Mandušić, Vesna
AU  - Petrović, Nina
AU  - Živaljević, Vladan R.
AU  - Paunović, Ivan R.
AU  - Diklić, Aleksandar
AU  - Saenko, Vladimir
AU  - Yamashita, Shunichi
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1944
AB  - A growing body of evidence suggests a role of the von Hippel-Lindau (VHL) tumor suppressor gene in the progression of papillary thyroid carcinoma (PTC). Our previous study of VHL in PTCs showed that lower VHL expression was associated with aggressive tumor features, but we found no evidence for VHL downregulation through common genetic or epigenetic modifications. Several studies pointed to a role of microRNA-92a (miR-92a) in the regulation of VHL expression in different cancers. In the present study, we examined the expression levels of VHL mRNA and miR-92a in 42 pairs of PTCs and matched non-tumor thyroid tissues by means of quantitative RT-PCR. We explored the correlation between them and their association with clinicopathological parameters. The results revealed that both VHL and miR-92a were either up-or downregulated in PTCs compared to corresponding non-tumor tissues. On univariate analysis, lower VHL levels were significantly associated with extrathyroid spread (P = 0.022) and capsular invasion (P = 0.032). Multivariate analysis confirmed the association of low VHL with extrathyroid spread (OR 0.246, 95% CI 0.069-0.872, P = 0.038). Higher miR-92a among PTC tissues associated with the presence of nodal metastases (univariate analysis: P = 0.012; multivariate: OR 4.703, 95% CI 1.109-19.938, P = 0.036). A negative correlation between VHL and miR-92a was observed in a subgroup of PTCs having vascular invasion (P = 0.033, r = -0.673). The data here reported demonstrate that the expression of both VHL and miR-92a is deregulated in PTC tissues and that in some PTCs they may have opposite roles. These roles, as well as their diagnostic and/or prognostic utility, remain to be clarified.
T2  - Medical Oncology
T1  - Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters
VL  - 35
IS  - 2
DO  - 10.1007/s12032-017-1066-3
ER  - 

@article{
author = "Todorović, Lidija and Stanojević, Boban and Mandušić, Vesna and Petrović, Nina and Živaljević, Vladan R. and Paunović, Ivan R. and Diklić, Aleksandar and Saenko, Vladimir and Yamashita, Shunichi",
year = "2018",
abstract = "A growing body of evidence suggests a role of the von Hippel-Lindau (VHL) tumor suppressor gene in the progression of papillary thyroid carcinoma (PTC). Our previous study of VHL in PTCs showed that lower VHL expression was associated with aggressive tumor features, but we found no evidence for VHL downregulation through common genetic or epigenetic modifications. Several studies pointed to a role of microRNA-92a (miR-92a) in the regulation of VHL expression in different cancers. In the present study, we examined the expression levels of VHL mRNA and miR-92a in 42 pairs of PTCs and matched non-tumor thyroid tissues by means of quantitative RT-PCR. We explored the correlation between them and their association with clinicopathological parameters. The results revealed that both VHL and miR-92a were either up-or downregulated in PTCs compared to corresponding non-tumor tissues. On univariate analysis, lower VHL levels were significantly associated with extrathyroid spread (P = 0.022) and capsular invasion (P = 0.032). Multivariate analysis confirmed the association of low VHL with extrathyroid spread (OR 0.246, 95% CI 0.069-0.872, P = 0.038). Higher miR-92a among PTC tissues associated with the presence of nodal metastases (univariate analysis: P = 0.012; multivariate: OR 4.703, 95% CI 1.109-19.938, P = 0.036). A negative correlation between VHL and miR-92a was observed in a subgroup of PTCs having vascular invasion (P = 0.033, r = -0.673). The data here reported demonstrate that the expression of both VHL and miR-92a is deregulated in PTC tissues and that in some PTCs they may have opposite roles. These roles, as well as their diagnostic and/or prognostic utility, remain to be clarified.",
journal = "Medical Oncology",
title = "Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters",
volume = "35",
number = "2",
doi = "10.1007/s12032-017-1066-3"
}

Todorović, L., Stanojević, B., Mandušić, V., Petrović, N., Živaljević, V. R., Paunović, I. R., Diklić, A., Saenko, V.,& Yamashita, S.. (2018). Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters. in Medical Oncology, 35(2).
https://doi.org/10.1007/s12032-017-1066-3

Todorović L, Stanojević B, Mandušić V, Petrović N, Živaljević VR, Paunović IR, Diklić A, Saenko V, Yamashita S. Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters. in Medical Oncology. 2018;35(2).
doi:10.1007/s12032-017-1066-3 .

Todorović, Lidija, Stanojević, Boban, Mandušić, Vesna, Petrović, Nina, Živaljević, Vladan R., Paunović, Ivan R., Diklić, Aleksandar, Saenko, Vladimir, Yamashita, Shunichi, "Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters" in Medical Oncology, 35, no. 2 (2018),
https://doi.org/10.1007/s12032-017-1066-3 . .

TY  - JOUR
AU  - Stanojević, Boban
AU  - Saenko, Vladimir
AU  - Todorović, Lidija
AU  - Petrović, Nina
AU  - Nikolić, Dragan
AU  - Živaljević, Vladan R.
AU  - Paunović, Ivan R.
AU  - Nakashima, Masahiro
AU  - Yamashita, Shunichi
AU  - Džodić, Radan R.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/340
AB  - Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR=5.78, 95% CI 3.17-10.53, P LT 0.0001), classical papillary morphology of the tumor (OR=2.92, 95% CI 1.33-6.44, P=0.008) and multifocality (OR=1.96, 95% CI 1.06-3.62, P=0.031). In disease-free survival analysis, low VHL expression had marginal significance (P=0.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated.
T2  - PLOS One
T1  - Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma
VL  - 9
IS  - 12
DO  - 10.1371/journal.pone.0114511
ER  - 

@article{
author = "Stanojević, Boban and Saenko, Vladimir and Todorović, Lidija and Petrović, Nina and Nikolić, Dragan and Živaljević, Vladan R. and Paunović, Ivan R. and Nakashima, Masahiro and Yamashita, Shunichi and Džodić, Radan R.",
year = "2014",
abstract = "Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR=5.78, 95% CI 3.17-10.53, P LT 0.0001), classical papillary morphology of the tumor (OR=2.92, 95% CI 1.33-6.44, P=0.008) and multifocality (OR=1.96, 95% CI 1.06-3.62, P=0.031). In disease-free survival analysis, low VHL expression had marginal significance (P=0.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated.",
journal = "PLOS One",
title = "Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma",
volume = "9",
number = "12",
doi = "10.1371/journal.pone.0114511"
}

Stanojević, B., Saenko, V., Todorović, L., Petrović, N., Nikolić, D., Živaljević, V. R., Paunović, I. R., Nakashima, M., Yamashita, S.,& Džodić, R. R.. (2014). Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma. in PLOS One, 9(12).
https://doi.org/10.1371/journal.pone.0114511

Stanojević B, Saenko V, Todorović L, Petrović N, Nikolić D, Živaljević VR, Paunović IR, Nakashima M, Yamashita S, Džodić RR. Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma. in PLOS One. 2014;9(12).
doi:10.1371/journal.pone.0114511 .

Stanojević, Boban, Saenko, Vladimir, Todorović, Lidija, Petrović, Nina, Nikolić, Dragan, Živaljević, Vladan R., Paunović, Ivan R., Nakashima, Masahiro, Yamashita, Shunichi, Džodić, Radan R., "Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma" in PLOS One, 9, no. 12 (2014),
https://doi.org/10.1371/journal.pone.0114511 . .

TY  - JOUR
AU  - Živaljević, Vladan R.
AU  - Taušanović, Katarina
AU  - Šipetić, Sandra
AU  - Paunović, Ivan R.
AU  - Diklić, Aleksandar
AU  - Kovačević, Bojan
AU  - Stojanović, Dragoš
AU  - Živić, Rastko
AU  - Stanojević, Boban
AU  - Kalezić, Nevena
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5704
AB  - Thyroid carcinomas in children and adolescents are rare tumors and the most common among them is papillary thyroid cancer (PTC). Its etiology is still under research and has not been clearly defined thus far, especially in young individuals. The aim of this case-control study was to determine potential risk factors for the development of PTC in children and adolescents. This type of study has not been carried out previously in this age group. A case-control study was carried out during a 15-year period, between 1995 and 2009. The case group included 75 patients with PTC younger than 20 years of age, with the youngest patient being 6.5 years old; 45 patients were female and 30 were male. The control group included the same number of participants, and the cases were individually matched by sex, age, and place of residence. Conditional univariate and multivariate logistic regression methods were applied in data analysis. According to univariate logistic regression analysis, PTC in children and adolescents was significantly related to the following factors: family history of thyroid cancer, family history of residence in an endemic-goiter area, family history of benign thyroid disease, and family history of nonthyroid malignant tumors. According to the multivariate logistic regression method, PTC in children and adolescents was independently related to a family history of thyroid cancer (odds ratio=4.5, 95% confidence interval=1.2-19.8) and a family history of nonthyroid malignant tumors (odds ratio=3.8, 95% confidence interval=1.4-8.7). In conclusion, all of the factors associated with the development of PTC in children and adolescents were related to their family history. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams and Wilkins.
T2  - European Journal of Cancer Prevention
T1  - A case-control study of papillary thyroid cancer in children and adolescents
VL  - 22
IS  - 6
SP  - 561
EP  - 565
DO  - 10.1097/CEJ.0b013e3283603494
ER  - 

@article{
author = "Živaljević, Vladan R. and Taušanović, Katarina and Šipetić, Sandra and Paunović, Ivan R. and Diklić, Aleksandar and Kovačević, Bojan and Stojanović, Dragoš and Živić, Rastko and Stanojević, Boban and Kalezić, Nevena",
year = "2013",
abstract = "Thyroid carcinomas in children and adolescents are rare tumors and the most common among them is papillary thyroid cancer (PTC). Its etiology is still under research and has not been clearly defined thus far, especially in young individuals. The aim of this case-control study was to determine potential risk factors for the development of PTC in children and adolescents. This type of study has not been carried out previously in this age group. A case-control study was carried out during a 15-year period, between 1995 and 2009. The case group included 75 patients with PTC younger than 20 years of age, with the youngest patient being 6.5 years old; 45 patients were female and 30 were male. The control group included the same number of participants, and the cases were individually matched by sex, age, and place of residence. Conditional univariate and multivariate logistic regression methods were applied in data analysis. According to univariate logistic regression analysis, PTC in children and adolescents was significantly related to the following factors: family history of thyroid cancer, family history of residence in an endemic-goiter area, family history of benign thyroid disease, and family history of nonthyroid malignant tumors. According to the multivariate logistic regression method, PTC in children and adolescents was independently related to a family history of thyroid cancer (odds ratio=4.5, 95% confidence interval=1.2-19.8) and a family history of nonthyroid malignant tumors (odds ratio=3.8, 95% confidence interval=1.4-8.7). In conclusion, all of the factors associated with the development of PTC in children and adolescents were related to their family history. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams and Wilkins.",
journal = "European Journal of Cancer Prevention",
title = "A case-control study of papillary thyroid cancer in children and adolescents",
volume = "22",
number = "6",
pages = "561-565",
doi = "10.1097/CEJ.0b013e3283603494"
}

Živaljević, V. R., Taušanović, K., Šipetić, S., Paunović, I. R., Diklić, A., Kovačević, B., Stojanović, D., Živić, R., Stanojević, B.,& Kalezić, N.. (2013). A case-control study of papillary thyroid cancer in children and adolescents. in European Journal of Cancer Prevention, 22(6), 561-565.
https://doi.org/10.1097/CEJ.0b013e3283603494

Živaljević VR, Taušanović K, Šipetić S, Paunović IR, Diklić A, Kovačević B, Stojanović D, Živić R, Stanojević B, Kalezić N. A case-control study of papillary thyroid cancer in children and adolescents. in European Journal of Cancer Prevention. 2013;22(6):561-565.
doi:10.1097/CEJ.0b013e3283603494 .

Živaljević, Vladan R., Taušanović, Katarina, Šipetić, Sandra, Paunović, Ivan R., Diklić, Aleksandar, Kovačević, Bojan, Stojanović, Dragoš, Živić, Rastko, Stanojević, Boban, Kalezić, Nevena, "A case-control study of papillary thyroid cancer in children and adolescents" in European Journal of Cancer Prevention, 22, no. 6 (2013):561-565,
https://doi.org/10.1097/CEJ.0b013e3283603494 . .