Bondžić, Aleksandra M.

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Authority KeyName Variants
orcid::0000-0002-7403-2318
  • Bondžić, Aleksandra M. (19)
  • Milenković, Aleksandra S. (11)
Projects
Studies of enzyme interactions with toxic and pharmacologically active molecules Advanced technologies for monitoring and environmental protection from chemical pollutants and radiation burden
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) Experimental and theoretical study of reactivity and biological activity of stereodefined thiazolidines and their synthetic analogues
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) Beneficentia Stiftung (Vaduz), ITT (Istituto Toscano Tumori), Fondazione Cassa Risparmio Firenze (CRF), AIRC [IG-16049], AIRC-FIRC (Fondazione Italiana per la Ricerca sul Cancro) [18044]
Beneficentia Stiftung (Vaduz, Liechtenstein), AIRC [IG-16049], ITT, Fondazione CRF, CIRCMSB CMST COST Action [CM1203 (PoCheMoN)]
COST Action [CA15106 - CHAOS] COST Action [CA15135 - MuTaLig]
COST action CM1203 Polyoxometalate Chemistry for Molecular Nanoscience (PoCheMoN), COST-STSM-ECOST-STSM-CM1203-030416-072554 COST Action [MP1302 - Nanospectroscopy]
European Union (EU) [POPW.01.03.00-20-034/09-00] Foundation for Science and Technology (FCT) and Portugal 2020 [CEECIND/03708/2017]
Foundation for Science and Technology (FCT) and Portugal 2020 [IF/01395/2013/CP1163/CT005] Foundation for Science and Technology (FCT) and Portugal 2020 [LISBOA-01-0145FEDER-029697]
Foundation for Science and Technology (FCT) and Portugal 2020 [SFRH/BSAB/150368] Foundation for Science and Technology (FCT) and Portugal 2020 [UIDB/00100/2020]
Fundacao para a Ciencia e Tecnologia do Ministerio da Ciencia, Tecnologia e Ensino Superior (FCT/MCTES) [UID/FIS/00068/2013] HFRI [655]
Application of the EIIP/ISM bioinformatics platform in discovery of novel therapeutic targets and potential therapeutic molecules info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS/
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200122 (University of Kragujevac, Faculty of Science) Functional, Functionalized and Advanced Nanomaterials
Istraživanje mehanizma interakcija biološki aktivnih jedinjenja sa biomolekulima RUDN University Program 5100
The State Scholarships Foundation (IKY) [MIS 5033021]

Author's Bibliography

Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos

Bondžić, Aleksandra M.; Lazarević-Pašti, Tamara; Pašti, Igor A.; Bondžić, Bojan P.; Momčilović, Miloš; Loosen, Alexandra; Parac-Vogt, Tatjana N.

(2022)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Lazarević-Pašti, Tamara
AU  - Pašti, Igor A.
AU  - Bondžić, Bojan P.
AU  - Momčilović, Miloš
AU  - Loosen, Alexandra
AU  - Parac-Vogt, Tatjana N.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10210
AB  - Organophosphate-based pesticides have remarkably contributed to the agriculture industry, but their toxicity has a large negative impact on the environment as well as on the health of humans and other living organisms. Most of the methods developed to remedy the organophosphate pesticide toxicity are very time-consuming and are based on their adsorption onto different materials and/or their degradation to nontoxic species. In this study, detoxification of three structurally different organophosphate pesticides was investigated using an NU-1000 metal–organic framework. We showed that NU-1000 is an excellent agent for fast (average time ≤ 3 min) and effective removal of organophosphate pesticides with an aromatic heterocyclic moiety. In particular, superior detoxification of chlorpyrifos solution after NU-1000 treatment was achieved after only 1 min. The combination of experimental and computational methods revealed that the synergic effects of sorption and hydrolysis are responsible for the superior removal of CHP by NU-1000. The sorption process occurs on the Zr node (chemisorption) and pyrene linkers (physisorption) following pseudo-first-order kinetics during the first minute, and a pseudo-second-order model fits the entire time range. The multilayer adsorption of chlorpyrifos or its hydrolyzed product, 3,5,6-trichloro-2-pyridinol, takes place on a pyrene linker, whereas the aliphatic part of the molecule remains chemisorbed on the Zr node. Such unique synergy between induced sorption and hydrolysis of chlorpyrifos by NU-1000 results in its fast and effective removal with rapid detoxification in non-buffered solutions.
T2  - ACS Applied Nano Materials
T1  - Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos
DO  - 10.1021/acsanm.1c03863
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Lazarević-Pašti, Tamara and Pašti, Igor A. and Bondžić, Bojan P. and Momčilović, Miloš and Loosen, Alexandra and Parac-Vogt, Tatjana N.",
year = "2022",
abstract = "Organophosphate-based pesticides have remarkably contributed to the agriculture industry, but their toxicity has a large negative impact on the environment as well as on the health of humans and other living organisms. Most of the methods developed to remedy the organophosphate pesticide toxicity are very time-consuming and are based on their adsorption onto different materials and/or their degradation to nontoxic species. In this study, detoxification of three structurally different organophosphate pesticides was investigated using an NU-1000 metal–organic framework. We showed that NU-1000 is an excellent agent for fast (average time ≤ 3 min) and effective removal of organophosphate pesticides with an aromatic heterocyclic moiety. In particular, superior detoxification of chlorpyrifos solution after NU-1000 treatment was achieved after only 1 min. The combination of experimental and computational methods revealed that the synergic effects of sorption and hydrolysis are responsible for the superior removal of CHP by NU-1000. The sorption process occurs on the Zr node (chemisorption) and pyrene linkers (physisorption) following pseudo-first-order kinetics during the first minute, and a pseudo-second-order model fits the entire time range. The multilayer adsorption of chlorpyrifos or its hydrolyzed product, 3,5,6-trichloro-2-pyridinol, takes place on a pyrene linker, whereas the aliphatic part of the molecule remains chemisorbed on the Zr node. Such unique synergy between induced sorption and hydrolysis of chlorpyrifos by NU-1000 results in its fast and effective removal with rapid detoxification in non-buffered solutions.",
journal = "ACS Applied Nano Materials",
title = "Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos",
doi = "10.1021/acsanm.1c03863"
}
Bondžić, A. M., Lazarević-Pašti, T., Pašti, I. A., Bondžić, B. P., Momčilović, M., Loosen, A.,& Parac-Vogt, T. N.. (2022). Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos. in ACS Applied Nano Materials.
https://doi.org/10.1021/acsanm.1c03863
Bondžić AM, Lazarević-Pašti T, Pašti IA, Bondžić BP, Momčilović M, Loosen A, Parac-Vogt TN. Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos. in ACS Applied Nano Materials. 2022;.
doi:10.1021/acsanm.1c03863 .
Bondžić, Aleksandra M., Lazarević-Pašti, Tamara, Pašti, Igor A., Bondžić, Bojan P., Momčilović, Miloš, Loosen, Alexandra, Parac-Vogt, Tatjana N., "Synergistic Effect of Sorption and Hydrolysis by NU-1000 Nanostructures for Removal and Detoxification of Chlorpyrifos" in ACS Applied Nano Materials (2022),
https://doi.org/10.1021/acsanm.1c03863 . .

Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction

Džambaski, Zdravko; Bondžić, Aleksandra M.; Triandafillidi, Ierasia; Kokotos, Christoforos G.; Bondžić, Bojan P.

(2021)

TY  - JOUR
AU  - Džambaski, Zdravko
AU  - Bondžić, Aleksandra M.
AU  - Triandafillidi, Ierasia
AU  - Kokotos, Christoforos G.
AU  - Bondžić, Bojan P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9871
AB  - Herein, we demonstrate that organic, single-electron oxidant in the presence of diarylprolinol silylether type catalyst serves as a tool for the transformation of electron-rich enamines to iminium ions. These iminium ions take part in a subsequent Michael-initiated ring-closure (MIRC) reaction with in situ present nucleophile giving rise to overall cyclopropanation reaction of saturated aldehydes. Stereodefined cyclopropanes are obtained in high yields and selectivities. This one-pot transformation represents the additional example of saturated aldehydes being used in the coupled one-pot processes. (Figure presented.).
T2  - Advanced Synthesis and Catalysis
T1  - Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction
VL  - 363
IS  - 16
SP  - 4002
EP  - 4008
DO  - 10.1002/adsc.202100630
ER  - 
@article{
author = "Džambaski, Zdravko and Bondžić, Aleksandra M. and Triandafillidi, Ierasia and Kokotos, Christoforos G. and Bondžić, Bojan P.",
year = "2021",
abstract = "Herein, we demonstrate that organic, single-electron oxidant in the presence of diarylprolinol silylether type catalyst serves as a tool for the transformation of electron-rich enamines to iminium ions. These iminium ions take part in a subsequent Michael-initiated ring-closure (MIRC) reaction with in situ present nucleophile giving rise to overall cyclopropanation reaction of saturated aldehydes. Stereodefined cyclopropanes are obtained in high yields and selectivities. This one-pot transformation represents the additional example of saturated aldehydes being used in the coupled one-pot processes. (Figure presented.).",
journal = "Advanced Synthesis and Catalysis",
title = "Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction",
volume = "363",
number = "16",
pages = "4002-4008",
doi = "10.1002/adsc.202100630"
}
Džambaski, Z., Bondžić, A. M., Triandafillidi, I., Kokotos, C. G.,& Bondžić, B. P.. (2021). Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction. in Advanced Synthesis and Catalysis, 363(16), 4002-4008.
https://doi.org/10.1002/adsc.202100630
Džambaski Z, Bondžić AM, Triandafillidi I, Kokotos CG, Bondžić BP. Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction. in Advanced Synthesis and Catalysis. 2021;363(16):4002-4008.
doi:10.1002/adsc.202100630 .
Džambaski, Zdravko, Bondžić, Aleksandra M., Triandafillidi, Ierasia, Kokotos, Christoforos G., Bondžić, Bojan P., "Organocatalytic, Organic Oxidant Promoted, Enamine C−H Oxidation/Cyclopropanation Reaction" in Advanced Synthesis and Catalysis, 363, no. 16 (2021):4002-4008,
https://doi.org/10.1002/adsc.202100630 . .
11
2

Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action

Bondžić, Aleksandra M.; Žakula, Jelena J.; Korićanac, Lela B.; Keta, Otilija D.; Janjić, Goran V.; Đorđević, Ivana S.; Rajković, Snežana U.

(2021)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Žakula, Jelena J.
AU  - Korićanac, Lela B.
AU  - Keta, Otilija D.
AU  - Janjić, Goran V.
AU  - Đorđević, Ivana S.
AU  - Rajković, Snežana U.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10015
AB  - Herein, the stability, lipophilicity, in vitro cytotoxicity, and influence on acetylcholinesterase of five dinuclear platinum(II) complexes with the general formula [{Pt(en)Cl}2(μ-L)]2+ (L is a different aromatic nitrogen-containing heterocyclic bridging ligands pyrazine (pz, Pt1), pyridazine (pydz, Pt2), quinoxaline (qx, Pt3), phthalazine (phtz, Pt4) and quinazoline (qz, Pt5), while en is bidentate coordinated ethylenediamine) were evaluated. The most active analyzed platinum complexes induced time-dependent growth inhibition of A375, HeLa, PANC-1, and MRC-5 cells. The best efficiency was achieved on HeLa and PANC-1 cells for Pt1, Pt2, and Pt3 at the highest concentration, while Pt1 was significantly more potent than cisplatin at a lower concentration. Additionally, a lower effect on normal cells was observed compared to cisplatin, which may indicate potentially fewer side effects of these complexes. Selected complexes induce reactive oxygen species and apoptosis on tumor cell lines. The most potent reversible acetylcholinesterase (AChE) inhibitors were Pt2, Pt4, and Pt5. Pt1 showed similar inhibitory potential toward AChE as cisplatin, but a different type of inhibition, which could contribute to lower neurotoxicity. Docking studies revealed that Pt2 and Pt4 were bound to the active gorge above the catalytic triad. In contrast, the other complexes were bound to the edge of the active gorge without impeding the approach to the catalytic triad. According to this, Pt1 represents a promising compound with potent anticancer properties, high selectivity, and low neurotoxicity.
T2  - Chemico-Biological Interactions
T1  - Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action
SP  - 109708
DO  - 10.1016/j.cbi.2021.109708
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Žakula, Jelena J. and Korićanac, Lela B. and Keta, Otilija D. and Janjić, Goran V. and Đorđević, Ivana S. and Rajković, Snežana U.",
year = "2021",
abstract = "Herein, the stability, lipophilicity, in vitro cytotoxicity, and influence on acetylcholinesterase of five dinuclear platinum(II) complexes with the general formula [{Pt(en)Cl}2(μ-L)]2+ (L is a different aromatic nitrogen-containing heterocyclic bridging ligands pyrazine (pz, Pt1), pyridazine (pydz, Pt2), quinoxaline (qx, Pt3), phthalazine (phtz, Pt4) and quinazoline (qz, Pt5), while en is bidentate coordinated ethylenediamine) were evaluated. The most active analyzed platinum complexes induced time-dependent growth inhibition of A375, HeLa, PANC-1, and MRC-5 cells. The best efficiency was achieved on HeLa and PANC-1 cells for Pt1, Pt2, and Pt3 at the highest concentration, while Pt1 was significantly more potent than cisplatin at a lower concentration. Additionally, a lower effect on normal cells was observed compared to cisplatin, which may indicate potentially fewer side effects of these complexes. Selected complexes induce reactive oxygen species and apoptosis on tumor cell lines. The most potent reversible acetylcholinesterase (AChE) inhibitors were Pt2, Pt4, and Pt5. Pt1 showed similar inhibitory potential toward AChE as cisplatin, but a different type of inhibition, which could contribute to lower neurotoxicity. Docking studies revealed that Pt2 and Pt4 were bound to the active gorge above the catalytic triad. In contrast, the other complexes were bound to the edge of the active gorge without impeding the approach to the catalytic triad. According to this, Pt1 represents a promising compound with potent anticancer properties, high selectivity, and low neurotoxicity.",
journal = "Chemico-Biological Interactions",
title = "Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action",
pages = "109708",
doi = "10.1016/j.cbi.2021.109708"
}
Bondžić, A. M., Žakula, J. J., Korićanac, L. B., Keta, O. D., Janjić, G. V., Đorđević, I. S.,& Rajković, S. U.. (2021). Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action. in Chemico-Biological Interactions, 109708.
https://doi.org/10.1016/j.cbi.2021.109708
Bondžić AM, Žakula JJ, Korićanac LB, Keta OD, Janjić GV, Đorđević IS, Rajković SU. Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action. in Chemico-Biological Interactions. 2021;:109708.
doi:10.1016/j.cbi.2021.109708 .
Bondžić, Aleksandra M., Žakula, Jelena J., Korićanac, Lela B., Keta, Otilija D., Janjić, Goran V., Đorđević, Ivana S., Rajković, Snežana U., "Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action" in Chemico-Biological Interactions (2021):109708,
https://doi.org/10.1016/j.cbi.2021.109708 . .

Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action

Bondžić, Aleksandra M.; Senćanski, Milan V.; Vujačić Nikezić, Ana V.; Kirillova, Marina V.; André, Vania; Kirillov, Alexander M.; Bondžić, Bojan P.

(2020)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Senćanski, Milan V.
AU  - Vujačić Nikezić, Ana V.
AU  - Kirillova, Marina V.
AU  - André, Vania
AU  - Kirillov, Alexander M.
AU  - Bondžić, Bojan P.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8806
AB  - Three coordination compounds featuring different types of tetracopper(II) cores, namely [O ⊂ Cu4N(CH2CH2O)34(BOH)4][BF4]2 (1), [Cu4(μ4-H2edte)(μ5-H2edte)(sal)2]n·7nH2O, (H4edte = N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine, H2sal = salicylic acid) (2), and [Cu4(μ3-Hbes)4(μ-hba)K(H2O)3]n, H3bes = N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (3), were assayed for their potency to inhibit the acetyl (AChE) and butyrylcholinesterase (BuChE) enzymes aiming to test these compounds as potential dual inhibitors in the treatment of Alzheimer's disease. All the investigated compounds showed a strong inhibitory potency toward both enzymes with IC50 values in micromolar range of concentration; compound 1 displayed the most potent inhibitory behaviour toward both enzymes. The mechanism of the AChE and BuChE inhibition was examined by enzyme kinetic measurements. The obtained kinetic parameters, Vmax and Km indicated an uncompetitive type of inhibition of both enzymes by compound 1. For the other two compounds a non-competitive inhibition mode was observed. To get further insight into the mechanism of action and to elucidate binding modes in details we examined the interactions of 1–3 with acetylcholinesterase, using molecular docking approach. Grid based docking studies indicated that these compounds can bind to peripheral anionic site (PAS) of the AChE with Ki values in micromolar range. Moreover, blind docking revealed the capability of investigated compounds to bind to new allosteric site (i.e. binding site II) distinct from PAS. Showing that these Cu-based compounds can act as new allosteric inhibitors of AChE and identifying novel allosteric binding site on AChE represents a significant contribution toward the design of novel and more effective inhibitors of AChE. © 2020 Elsevier Inc.
T2  - Journal of Inorganic Biochemistry
T1  - Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action
VL  - 205
SP  - 110990
DO  - 10.1016/j.jinorgbio.2019.110990
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Senćanski, Milan V. and Vujačić Nikezić, Ana V. and Kirillova, Marina V. and André, Vania and Kirillov, Alexander M. and Bondžić, Bojan P.",
year = "2020",
abstract = "Three coordination compounds featuring different types of tetracopper(II) cores, namely [O ⊂ Cu4N(CH2CH2O)34(BOH)4][BF4]2 (1), [Cu4(μ4-H2edte)(μ5-H2edte)(sal)2]n·7nH2O, (H4edte = N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine, H2sal = salicylic acid) (2), and [Cu4(μ3-Hbes)4(μ-hba)K(H2O)3]n, H3bes = N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (3), were assayed for their potency to inhibit the acetyl (AChE) and butyrylcholinesterase (BuChE) enzymes aiming to test these compounds as potential dual inhibitors in the treatment of Alzheimer's disease. All the investigated compounds showed a strong inhibitory potency toward both enzymes with IC50 values in micromolar range of concentration; compound 1 displayed the most potent inhibitory behaviour toward both enzymes. The mechanism of the AChE and BuChE inhibition was examined by enzyme kinetic measurements. The obtained kinetic parameters, Vmax and Km indicated an uncompetitive type of inhibition of both enzymes by compound 1. For the other two compounds a non-competitive inhibition mode was observed. To get further insight into the mechanism of action and to elucidate binding modes in details we examined the interactions of 1–3 with acetylcholinesterase, using molecular docking approach. Grid based docking studies indicated that these compounds can bind to peripheral anionic site (PAS) of the AChE with Ki values in micromolar range. Moreover, blind docking revealed the capability of investigated compounds to bind to new allosteric site (i.e. binding site II) distinct from PAS. Showing that these Cu-based compounds can act as new allosteric inhibitors of AChE and identifying novel allosteric binding site on AChE represents a significant contribution toward the design of novel and more effective inhibitors of AChE. © 2020 Elsevier Inc.",
journal = "Journal of Inorganic Biochemistry",
title = "Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action",
volume = "205",
pages = "110990",
doi = "10.1016/j.jinorgbio.2019.110990"
}
Bondžić, A. M., Senćanski, M. V., Vujačić Nikezić, A. V., Kirillova, M. V., André, V., Kirillov, A. M.,& Bondžić, B. P.. (2020). Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action. in Journal of Inorganic Biochemistry, 205, 110990.
https://doi.org/10.1016/j.jinorgbio.2019.110990
Bondžić AM, Senćanski MV, Vujačić Nikezić AV, Kirillova MV, André V, Kirillov AM, Bondžić BP. Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action. in Journal of Inorganic Biochemistry. 2020;205:110990.
doi:10.1016/j.jinorgbio.2019.110990 .
Bondžić, Aleksandra M., Senćanski, Milan V., Vujačić Nikezić, Ana V., Kirillova, Marina V., André, Vania, Kirillov, Alexander M., Bondžić, Bojan P., "Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action" in Journal of Inorganic Biochemistry, 205 (2020):110990,
https://doi.org/10.1016/j.jinorgbio.2019.110990 . .
10
6
5
5

A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition

Bondžić, Aleksandra M.; Lazarević-Pašti, Tamara; Leskovac, Andreja; Petrović, Sandra; Čolović, Mirjana B.; Parac Vogt, Tatjana N.; Janjić, Goran V.

(2020)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Čolović, Mirjana B.
AU  - Parac Vogt, Tatjana N.
AU  - Janjić, Goran V.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9028
AB  - Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.
T2  - European Journal of Pharmaceutical Sciences
T1  - A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition
VL  - 151
SP  - 105376
DO  - 10.1016/j.ejps.2020.105376
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Lazarević-Pašti, Tamara and Leskovac, Andreja and Petrović, Sandra and Čolović, Mirjana B. and Parac Vogt, Tatjana N. and Janjić, Goran V.",
year = "2020",
abstract = "Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.",
journal = "European Journal of Pharmaceutical Sciences",
title = "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition",
volume = "151",
pages = "105376",
doi = "10.1016/j.ejps.2020.105376"
}
Bondžić, A. M., Lazarević-Pašti, T., Leskovac, A., Petrović, S., Čolović, M. B., Parac Vogt, T. N.,& Janjić, G. V.. (2020). A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences, 151, 105376.
https://doi.org/10.1016/j.ejps.2020.105376
Bondžić AM, Lazarević-Pašti T, Leskovac A, Petrović S, Čolović MB, Parac Vogt TN, Janjić GV. A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences. 2020;151:105376.
doi:10.1016/j.ejps.2020.105376 .
Bondžić, Aleksandra M., Lazarević-Pašti, Tamara, Leskovac, Andreja, Petrović, Sandra, Čolović, Mirjana B., Parac Vogt, Tatjana N., Janjić, Goran V., "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition" in European Journal of Pharmaceutical Sciences, 151 (2020):105376,
https://doi.org/10.1016/j.ejps.2020.105376 . .
8
6

Drug delivery systems based on nanoparticles and related nanostructures

Vujačić Nikezić, Ana V.; Bondžić, Aleksandra M.; Vasić, Vesna M.

(2020)

TY  - JOUR
AU  - Vujačić Nikezić, Ana V.
AU  - Bondžić, Aleksandra M.
AU  - Vasić, Vesna M.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9049
AB  - A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.
T2  - European Journal of Pharmaceutical Sciences
T1  - Drug delivery systems based on nanoparticles and related nanostructures
VL  - 151
SP  - 105412
DO  - 10.1016/j.ejps.2020.105412
ER  - 
@article{
author = "Vujačić Nikezić, Ana V. and Bondžić, Aleksandra M. and Vasić, Vesna M.",
year = "2020",
abstract = "A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Drug delivery systems based on nanoparticles and related nanostructures",
volume = "151",
pages = "105412",
doi = "10.1016/j.ejps.2020.105412"
}
Vujačić Nikezić, A. V., Bondžić, A. M.,& Vasić, V. M.. (2020). Drug delivery systems based on nanoparticles and related nanostructures. in European Journal of Pharmaceutical Sciences, 151, 105412.
https://doi.org/10.1016/j.ejps.2020.105412
Vujačić Nikezić AV, Bondžić AM, Vasić VM. Drug delivery systems based on nanoparticles and related nanostructures. in European Journal of Pharmaceutical Sciences. 2020;151:105412.
doi:10.1016/j.ejps.2020.105412 .
Vujačić Nikezić, Ana V., Bondžić, Aleksandra M., Vasić, Vesna M., "Drug delivery systems based on nanoparticles and related nanostructures" in European Journal of Pharmaceutical Sciences, 151 (2020):105412,
https://doi.org/10.1016/j.ejps.2020.105412 . .
1
20
16

Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue

Bondžić, Aleksandra M.; Leskovac, Andreja; Petrović, Sandra; Vasić Anićijević, Dragana D.; Luce, Marco; Massai, Lara; Generosi, Amanda; Paci, Barbara; Cricenti, Antonio; Messori, Luigi; Vasić, Vesna M.

(2019)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Vasić Anićijević, Dragana D.
AU  - Luce, Marco
AU  - Massai, Lara
AU  - Generosi, Amanda
AU  - Paci, Barbara
AU  - Cricenti, Antonio
AU  - Messori, Luigi
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8747
AB  - Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)2][PF6], where (N,N)=2,2′-bipyridine; [Au(C,N)(AcO)2], where (C,N)=deprotonated 6-(1,1-dimethylbenzyl)-pyridine; [Au(C,N,N)(OH)][PF6], where (C,N,N)=deprotonated 6-(1,1-dimethylbenzyl)-2,2′-bipyridine, to assess the chance of tracking their subcellular distribution by atomic force microscopy (AFM), and surface enhanced Raman spectroscopy (SERS) techniques. An extensive physicochemical characterization of the formed conjugates was, thus, carried out by applying a variety of methods (density functional theory—DFT, UV/Vis spectrophotometry, AFM, Raman spectroscopy, and SERS). The resulting gold(III) complexes/AuNPs conjugates turned out to be pretty stable. Interestingly, they exhibited a dramatically increased resonance intensity in the Raman spectra induced by AuNPs. For testing the use of the functionalized AuNPs for biosensing, their distribution in the nuclear, cytosolic, and membrane cell fractions obtained from human lymphocytes was investigated by AFM and SERS. The conjugates were detected in the membrane and nuclear cell fractions but not in the cytosol. The AFM method confirmed that conjugates induced changes in the morphology and nanostructure of the membrane and nuclear fractions. The obtained results point out that the conjugates formed between AuNPs and gold(III) complexes may be used as a tool for tracking metallodrug distribution in the different cell fractions.
T2  - International Journal of Molecular Sciences
T1  - Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue
VL  - 20
IS  - 24
SP  - 6306
DO  - 10.3390/ijms20246306
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Leskovac, Andreja and Petrović, Sandra and Vasić Anićijević, Dragana D. and Luce, Marco and Massai, Lara and Generosi, Amanda and Paci, Barbara and Cricenti, Antonio and Messori, Luigi and Vasić, Vesna M.",
year = "2019",
abstract = "Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)2][PF6], where (N,N)=2,2′-bipyridine; [Au(C,N)(AcO)2], where (C,N)=deprotonated 6-(1,1-dimethylbenzyl)-pyridine; [Au(C,N,N)(OH)][PF6], where (C,N,N)=deprotonated 6-(1,1-dimethylbenzyl)-2,2′-bipyridine, to assess the chance of tracking their subcellular distribution by atomic force microscopy (AFM), and surface enhanced Raman spectroscopy (SERS) techniques. An extensive physicochemical characterization of the formed conjugates was, thus, carried out by applying a variety of methods (density functional theory—DFT, UV/Vis spectrophotometry, AFM, Raman spectroscopy, and SERS). The resulting gold(III) complexes/AuNPs conjugates turned out to be pretty stable. Interestingly, they exhibited a dramatically increased resonance intensity in the Raman spectra induced by AuNPs. For testing the use of the functionalized AuNPs for biosensing, their distribution in the nuclear, cytosolic, and membrane cell fractions obtained from human lymphocytes was investigated by AFM and SERS. The conjugates were detected in the membrane and nuclear cell fractions but not in the cytosol. The AFM method confirmed that conjugates induced changes in the morphology and nanostructure of the membrane and nuclear fractions. The obtained results point out that the conjugates formed between AuNPs and gold(III) complexes may be used as a tool for tracking metallodrug distribution in the different cell fractions.",
journal = "International Journal of Molecular Sciences",
title = "Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue",
volume = "20",
number = "24",
pages = "6306",
doi = "10.3390/ijms20246306"
}
Bondžić, A. M., Leskovac, A., Petrović, S., Vasić Anićijević, D. D., Luce, M., Massai, L., Generosi, A., Paci, B., Cricenti, A., Messori, L.,& Vasić, V. M.. (2019). Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue. in International Journal of Molecular Sciences, 20(24), 6306.
https://doi.org/10.3390/ijms20246306
Bondžić AM, Leskovac A, Petrović S, Vasić Anićijević DD, Luce M, Massai L, Generosi A, Paci B, Cricenti A, Messori L, Vasić VM. Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue. in International Journal of Molecular Sciences. 2019;20(24):6306.
doi:10.3390/ijms20246306 .
Bondžić, Aleksandra M., Leskovac, Andreja, Petrović, Sandra, Vasić Anićijević, Dragana D., Luce, Marco, Massai, Lara, Generosi, Amanda, Paci, Barbara, Cricenti, Antonio, Messori, Luigi, Vasić, Vesna M., "Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue" in International Journal of Molecular Sciences, 20, no. 24 (2019):6306,
https://doi.org/10.3390/ijms20246306 . .
3
1
3

Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles

Bondžić, Aleksandra M.; Vujačić Nikezić, Ana V.; Klekotka, Urszula; Marković, Mirjana; Vodnik, Vesna; Kalska, B.; Vasić, Vesna M.

(2019)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Vujačić Nikezić, Ana V.
AU  - Klekotka,  Urszula
AU  - Marković, Mirjana
AU  - Vodnik, Vesna
AU  - Kalska, B.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8812
AB  - Abstract: This paper presents the study of the interaction between gold nanoparticles (AuNPs) and antitumor gold complexes, [Au(OH)2(bipy)][PF6], [Au(CH3COO)2(pydmb-H)], and [Au(bipydmb-H)(OH)][PF6], in order to estimate the possibility for metal complex tracking in cells using nanospectroscopy approach. Decrease of intensity of the surface plasmon absorption band at 524 nm and the appearance of a new broad band at ∼640 nm, followed by their red shift were observed in the presence of the complexes. TEM images showed that the average size and shape of AuNPs did not change after the addition of gold complexes. DLS and zeta potential measurements pointed out to the metal complex adsorption on the surface of AuNPs followed by flocculation process. In addition, kinetic studies indicated strong bond formation between these complexes and AuNPs. Accordingly, AuNPs/complex conjugates have the potential to be applied for the tracking of these metal complexes in the cells using nanospectroscopy approach. © 2019, Pleiades Publishing, Ltd.
T2  - Russian Journal of Physical Chemistry A
T1  - Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles
VL  - 93
IS  - 13
SP  - 2765
EP  - 2770
DO  - 10.1134/S0036024419130065
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Vujačić Nikezić, Ana V. and Klekotka,  Urszula and Marković, Mirjana and Vodnik, Vesna and Kalska, B. and Vasić, Vesna M.",
year = "2019",
abstract = "Abstract: This paper presents the study of the interaction between gold nanoparticles (AuNPs) and antitumor gold complexes, [Au(OH)2(bipy)][PF6], [Au(CH3COO)2(pydmb-H)], and [Au(bipydmb-H)(OH)][PF6], in order to estimate the possibility for metal complex tracking in cells using nanospectroscopy approach. Decrease of intensity of the surface plasmon absorption band at 524 nm and the appearance of a new broad band at ∼640 nm, followed by their red shift were observed in the presence of the complexes. TEM images showed that the average size and shape of AuNPs did not change after the addition of gold complexes. DLS and zeta potential measurements pointed out to the metal complex adsorption on the surface of AuNPs followed by flocculation process. In addition, kinetic studies indicated strong bond formation between these complexes and AuNPs. Accordingly, AuNPs/complex conjugates have the potential to be applied for the tracking of these metal complexes in the cells using nanospectroscopy approach. © 2019, Pleiades Publishing, Ltd.",
journal = "Russian Journal of Physical Chemistry A",
title = "Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles",
volume = "93",
number = "13",
pages = "2765-2770",
doi = "10.1134/S0036024419130065"
}
Bondžić, A. M., Vujačić Nikezić, A. V., Klekotka, U., Marković, M., Vodnik, V., Kalska, B.,& Vasić, V. M.. (2019). Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles. in Russian Journal of Physical Chemistry A, 93(13), 2765-2770.
https://doi.org/10.1134/S0036024419130065
Bondžić AM, Vujačić Nikezić AV, Klekotka U, Marković M, Vodnik V, Kalska B, Vasić VM. Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles. in Russian Journal of Physical Chemistry A. 2019;93(13):2765-2770.
doi:10.1134/S0036024419130065 .
Bondžić, Aleksandra M., Vujačić Nikezić, Ana V., Klekotka,  Urszula, Marković, Mirjana, Vodnik, Vesna, Kalska, B., Vasić, Vesna M., "Insight into the Interaction between Selected Antitumor Gold(III) Complexes and Citrate Stabilized Gold Nanoparticles" in Russian Journal of Physical Chemistry A, 93, no. 13 (2019):2765-2770,
https://doi.org/10.1134/S0036024419130065 . .
1
1
2

Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites

Vujačić Nikezić, Ana V.; Janjić, Goran V.; Bondžić, Aleksandra M.; Zarić, Božidarka; Vasić Anićijević, Dragana D.; Momić, Tatjana; Vasić, Vesna M.

(2018)

TY  - JOUR
AU  - Vujačić Nikezić, Ana V.
AU  - Janjić, Goran V.
AU  - Bondžić, Aleksandra M.
AU  - Zarić, Božidarka
AU  - Vasić Anićijević, Dragana D.
AU  - Momić, Tatjana
AU  - Vasić, Vesna M.
PY  - 2018
UR  - http://xlink.rsc.org/?DOI=C8MT00111A
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7812
AB  - The present paper deals with investigation of the interaction between selected simple structure Au(iii) ([AuCl4]-, [AuCl2(dmso)2]+, [AuCl2(bipy)]+) and Pt(ii) ([PtCl2(dmso)2]) complexes with Na/K-ATPase as the target enzyme, using an experimental and theoretical approach. Reaction stoichiometries and binding constants for these enzyme/complex systems were determined, while kinetic measurements were used in order to reveal the type of inhibition. Based on the results obtained by quantum mechanical calculations (electrostatic surface potential (ESP), volume and surface of the complexes) the nature of the investigated complexes was characterized. By using the solvent accessible surface area (SASA) applied on specific inhibitory sites (ion channel and intracellular domains) the nature of these sites was described. Docking studies were used to determine the theoretical probability of the non-covalent metal binding site positions. Inhibition studies implied that all the investigated complexes decreased the activity of the enzyme while the kinetic analysis indicated an uncompetitive mode of inhibition for the selected complexes. Docking results suggested that the main inhibitory site of all these complexes is located in the ion translocation pathway on the extracellular side in the E2P enzyme conformation, similar to the case of cardiac glycosides, specific Na/K-ATPase inhibitors. Also, based on our knowledge, the hydrolyzed forms of [AuCl4]- and [PtCl2(dmso)2] complexes were investigated for the first time by theoretical calculations in this paper. Thereby, a new inhibitory site situated between the M2 and M4 helices was revealed. Binding in this site induces conformational changes in the enzyme domains and perturbs the E1-E2P conformational equilibrium, causing enzyme inhibition.
T2  - Metallomics
T1  - Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites
VL  - 10
IS  - 7
SP  - 1003
EP  - 1015
DO  - 10.1039/C8MT00111A
ER  - 
@article{
author = "Vujačić Nikezić, Ana V. and Janjić, Goran V. and Bondžić, Aleksandra M. and Zarić, Božidarka and Vasić Anićijević, Dragana D. and Momić, Tatjana and Vasić, Vesna M.",
year = "2018",
abstract = "The present paper deals with investigation of the interaction between selected simple structure Au(iii) ([AuCl4]-, [AuCl2(dmso)2]+, [AuCl2(bipy)]+) and Pt(ii) ([PtCl2(dmso)2]) complexes with Na/K-ATPase as the target enzyme, using an experimental and theoretical approach. Reaction stoichiometries and binding constants for these enzyme/complex systems were determined, while kinetic measurements were used in order to reveal the type of inhibition. Based on the results obtained by quantum mechanical calculations (electrostatic surface potential (ESP), volume and surface of the complexes) the nature of the investigated complexes was characterized. By using the solvent accessible surface area (SASA) applied on specific inhibitory sites (ion channel and intracellular domains) the nature of these sites was described. Docking studies were used to determine the theoretical probability of the non-covalent metal binding site positions. Inhibition studies implied that all the investigated complexes decreased the activity of the enzyme while the kinetic analysis indicated an uncompetitive mode of inhibition for the selected complexes. Docking results suggested that the main inhibitory site of all these complexes is located in the ion translocation pathway on the extracellular side in the E2P enzyme conformation, similar to the case of cardiac glycosides, specific Na/K-ATPase inhibitors. Also, based on our knowledge, the hydrolyzed forms of [AuCl4]- and [PtCl2(dmso)2] complexes were investigated for the first time by theoretical calculations in this paper. Thereby, a new inhibitory site situated between the M2 and M4 helices was revealed. Binding in this site induces conformational changes in the enzyme domains and perturbs the E1-E2P conformational equilibrium, causing enzyme inhibition.",
journal = "Metallomics",
title = "Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites",
volume = "10",
number = "7",
pages = "1003-1015",
doi = "10.1039/C8MT00111A"
}
Vujačić Nikezić, A. V., Janjić, G. V., Bondžić, A. M., Zarić, B., Vasić Anićijević, D. D., Momić, T.,& Vasić, V. M.. (2018). Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites. in Metallomics, 10(7), 1003-1015.
https://doi.org/10.1039/C8MT00111A
Vujačić Nikezić AV, Janjić GV, Bondžić AM, Zarić B, Vasić Anićijević DD, Momić T, Vasić VM. Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites. in Metallomics. 2018;10(7):1003-1015.
doi:10.1039/C8MT00111A .
Vujačić Nikezić, Ana V., Janjić, Goran V., Bondžić, Aleksandra M., Zarić, Božidarka, Vasić Anićijević, Dragana D., Momić, Tatjana, Vasić, Vesna M., "Interaction of Au(iii) and Pt(ii) complexes with Na/K-ATPase: experimental and theoretical study of reaction stoichiometry and binding sites" in Metallomics, 10, no. 7 (2018):1003-1015,
https://doi.org/10.1039/C8MT00111A . .
2
3
3

Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(III) complexes

Bondžić, Aleksandra M.; Janjić, Goran V.; Dramićanin, Miroslav; Messori, Luigi; Massai, Lara; Parac Vogt, Tatjana N.; Vasić, Vesna M.

(2017)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Janjić, Goran V.
AU  - Dramićanin, Miroslav
AU  - Messori, Luigi
AU  - Massai, Lara
AU  - Parac Vogt, Tatjana N.
AU  - Vasić, Vesna M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1476
AB  - Na/K-ATPase is emerging as an important target for a variety of anticancer metal-based drugs. The interactions of Na/K-ATPase (in its E1 state) with three representative and structurally related cytotoxic gold(III) complexes, i.e. [Au(bipy)(OH)(2)][PF6], bipy = 2,2-bipyridine; [Au(py(dmb)-H)(CH3COO)(2)], py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine and [Au(bipy(dmb)-H)(OH)][PF6], bipy(c)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,20-bipyridine, are investigated here in depth using a variety of spectroscopic methods, in combination with docking studies. Detailed information is gained on the conformational and structural changes experienced by the enzyme upon binding of these gold(III) complexes. The quenching constants of intrinsic enzyme fluorescence, the fraction of Trp residues accessible to gold(III) complexes and the reaction stoichiometries were determined in various cases. Specific hypotheses are made concerning the binding mode of these gold(III) complexes to the enzyme and the likely binding sites. Differences in their binding behaviour toward Na/K-ATPase are explained on the ground of their distinctive structural features. The present results offer further support to the view that Na/K-ATPase may be a relevant biomolecular target for cytotoxic gold(III) compounds of medicinal interest and may thus be involved in their overall mode of action.
T2  - Metallomics
T1  - Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(III) complexes
VL  - 9
IS  - 3
SP  - 292
EP  - 300
DO  - 10.1039/c7mt00017k
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Janjić, Goran V. and Dramićanin, Miroslav and Messori, Luigi and Massai, Lara and Parac Vogt, Tatjana N. and Vasić, Vesna M.",
year = "2017",
abstract = "Na/K-ATPase is emerging as an important target for a variety of anticancer metal-based drugs. The interactions of Na/K-ATPase (in its E1 state) with three representative and structurally related cytotoxic gold(III) complexes, i.e. [Au(bipy)(OH)(2)][PF6], bipy = 2,2-bipyridine; [Au(py(dmb)-H)(CH3COO)(2)], py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine and [Au(bipy(dmb)-H)(OH)][PF6], bipy(c)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,20-bipyridine, are investigated here in depth using a variety of spectroscopic methods, in combination with docking studies. Detailed information is gained on the conformational and structural changes experienced by the enzyme upon binding of these gold(III) complexes. The quenching constants of intrinsic enzyme fluorescence, the fraction of Trp residues accessible to gold(III) complexes and the reaction stoichiometries were determined in various cases. Specific hypotheses are made concerning the binding mode of these gold(III) complexes to the enzyme and the likely binding sites. Differences in their binding behaviour toward Na/K-ATPase are explained on the ground of their distinctive structural features. The present results offer further support to the view that Na/K-ATPase may be a relevant biomolecular target for cytotoxic gold(III) compounds of medicinal interest and may thus be involved in their overall mode of action.",
journal = "Metallomics",
title = "Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(III) complexes",
volume = "9",
number = "3",
pages = "292-300",
doi = "10.1039/c7mt00017k"
}
Bondžić, A. M., Janjić, G. V., Dramićanin, M., Messori, L., Massai, L., Parac Vogt, T. N.,& Vasić, V. M.. (2017). Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(III) complexes. in Metallomics, 9(3), 292-300.
https://doi.org/10.1039/c7mt00017k
Bondžić AM, Janjić GV, Dramićanin M, Messori L, Massai L, Parac Vogt TN, Vasić VM. Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(III) complexes. in Metallomics. 2017;9(3):292-300.
doi:10.1039/c7mt00017k .
Bondžić, Aleksandra M., Janjić, Goran V., Dramićanin, Miroslav, Messori, Luigi, Massai, Lara, Parac Vogt, Tatjana N., Vasić, Vesna M., "Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(III) complexes" in Metallomics, 9, no. 3 (2017):292-300,
https://doi.org/10.1039/c7mt00017k . .
11
13
13

The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach

Bondžić, Aleksandra M.; Čolović, Mirjana B.; Janjić, Goran V.; Zarić, Božidarka; Petrović, Sandra; Krstić, Danijela Z.; Marzo, Tiziano; Messori, Luigi; Vasić, Vesna M.

(2017)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Čolović, Mirjana B.
AU  - Janjić, Goran V.
AU  - Zarić, Božidarka
AU  - Petrović, Sandra
AU  - Krstić, Danijela Z.
AU  - Marzo, Tiziano
AU  - Messori, Luigi
AU  - Vasić, Vesna M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1648
AB  - The in vitro effects of oxo-bridged binuclear gold(III) complexes, i.e., [(bipy2Me)(2)Au-2(mu-O)(2)][PF6](2) (Auoxo6), Au-2[(bipydmb-H)(2)(mu-O)][PF6] (Au(2)bipyC) and [Au-2(phen(2Me))(2)(mu-O)(2)](PF6)(2) (Au(2)phen) on Na/K-ATPase, purified from the porcine cerebral cortex, were investigated. All three studied gold complexes inhibited the enzyme activity in a concentration-dependent manner achieving IC50 values in the low micromolar range. Kinetic analysis suggested an uncompetitive mode of inhibition for Auoxo6 and Au(2)bipyC, and a mixed type one for Au(2)phen. Docking studies indicated that the inhibitory actions of all tested complexes are related to E2-P enzyme conformation binding to ion channel and intracellular part between N and P sub-domain. In addition, Au(2)phen was able to inhibit the enzyme by interacting with its extracellular part as well. Toxic effects of the gold(III) complexes were evaluated in vitro by following lactate dehydrogenase activity in rat brain synaptosomes and incidence of micronuclei and cytokinesis-block proliferation index in cultivated human lymphocytes. All investigated complexes turned out to induce cytogenetic damage consisting of a significant decrease in cell proliferation and an increase in micronuclei in a dose-dependent manner. On the other hand, lactate dehydrogenase activity, an indicator of membrane integrity/viability, was not affected by Auoxo6 and Au(2)bipyC, while Au(2)phen slightly modified its activity.
T2  - Journal of Biological Inorganic Chemistry
T1  - The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach
VL  - 22
IS  - 6
SP  - 819
EP  - 832
DO  - 10.1007/s00775-017-1460-5
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Čolović, Mirjana B. and Janjić, Goran V. and Zarić, Božidarka and Petrović, Sandra and Krstić, Danijela Z. and Marzo, Tiziano and Messori, Luigi and Vasić, Vesna M.",
year = "2017",
abstract = "The in vitro effects of oxo-bridged binuclear gold(III) complexes, i.e., [(bipy2Me)(2)Au-2(mu-O)(2)][PF6](2) (Auoxo6), Au-2[(bipydmb-H)(2)(mu-O)][PF6] (Au(2)bipyC) and [Au-2(phen(2Me))(2)(mu-O)(2)](PF6)(2) (Au(2)phen) on Na/K-ATPase, purified from the porcine cerebral cortex, were investigated. All three studied gold complexes inhibited the enzyme activity in a concentration-dependent manner achieving IC50 values in the low micromolar range. Kinetic analysis suggested an uncompetitive mode of inhibition for Auoxo6 and Au(2)bipyC, and a mixed type one for Au(2)phen. Docking studies indicated that the inhibitory actions of all tested complexes are related to E2-P enzyme conformation binding to ion channel and intracellular part between N and P sub-domain. In addition, Au(2)phen was able to inhibit the enzyme by interacting with its extracellular part as well. Toxic effects of the gold(III) complexes were evaluated in vitro by following lactate dehydrogenase activity in rat brain synaptosomes and incidence of micronuclei and cytokinesis-block proliferation index in cultivated human lymphocytes. All investigated complexes turned out to induce cytogenetic damage consisting of a significant decrease in cell proliferation and an increase in micronuclei in a dose-dependent manner. On the other hand, lactate dehydrogenase activity, an indicator of membrane integrity/viability, was not affected by Auoxo6 and Au(2)bipyC, while Au(2)phen slightly modified its activity.",
journal = "Journal of Biological Inorganic Chemistry",
title = "The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach",
volume = "22",
number = "6",
pages = "819-832",
doi = "10.1007/s00775-017-1460-5"
}
Bondžić, A. M., Čolović, M. B., Janjić, G. V., Zarić, B., Petrović, S., Krstić, D. Z., Marzo, T., Messori, L.,& Vasić, V. M.. (2017). The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach. in Journal of Biological Inorganic Chemistry, 22(6), 819-832.
https://doi.org/10.1007/s00775-017-1460-5
Bondžić AM, Čolović MB, Janjić GV, Zarić B, Petrović S, Krstić DZ, Marzo T, Messori L, Vasić VM. The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach. in Journal of Biological Inorganic Chemistry. 2017;22(6):819-832.
doi:10.1007/s00775-017-1460-5 .
Bondžić, Aleksandra M., Čolović, Mirjana B., Janjić, Goran V., Zarić, Božidarka, Petrović, Sandra, Krstić, Danijela Z., Marzo, Tiziano, Messori, Luigi, Vasić, Vesna M., "The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach" in Journal of Biological Inorganic Chemistry, 22, no. 6 (2017):819-832,
https://doi.org/10.1007/s00775-017-1460-5 . .
5
4
4

Modulation of acetylcholinesterase activity induced by polyoxotungstates

Čolović, Mirjana B.; Bondžić, Aleksandra M.; Kortz, U.; Vasić, Vesna M.; Krstić, Danijela Z.

(Society of Physical Chemists of Serbia, 2016)

TY  - CONF
AU  - Čolović, Mirjana B.
AU  - Bondžić, Aleksandra M.
AU  - Kortz, U.
AU  - Vasić, Vesna M.
AU  - Krstić, Danijela Z.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9208
AB  - The in  vitroinfluence  of  five  polyoxotungstates  containing  various  central atoms    on    acetylcholinesterase    (AChE)    activity    was    investigated. K6[PV3W9O40] × 3H2O, K6H2[TiW11CoO40] × 13H2O, (NH4)14[NaP5W30O110]    ×    31H2O,    K7[SiV3W9O40]    ×    10H2O,    and K7[Ti2PW10O40]   induced   the   enzyme   inhibition   in   a   concentration-dependent  manner.  Inhibitory  power  of  the  investigated  compounds  was evaluated  using  IC50values.  K7[SiV3W9O40]  ×  10H2O  affected  AChE activity with lowest potency (IC50 = 4.80 × 10-4mol/L). K6H2[TiW11CoO40] ×  13H2O  and  K7[Ti2PW10O40]  exhibited  high  affinity  toward  the  enzyme, inducing half-maximuminhibition at micromolar concentrations (1.14 × 10-6and 1.04 × 10-6mol/L, respectively), while the same effect was achieved in the  presence  of  about  fifty  times  higher  concentration  of  K6[PV3W9O40]  × 3H2O.  Finally,  (NH4)14[NaP5W30O110]  ×  31H2O  was  foundas  the  most potent   inhibitor   of   AChE   activity   (IC50 = 6.36   ×   10-7mol/L),   and consequently the most promising candidate for the treatment of neurological diseases associated with acetylcholine leakage.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
T1  - Modulation of acetylcholinesterase activity induced by polyoxotungstates
SP  - 451
EP  - 454
ER  - 
@conference{
author = "Čolović, Mirjana B. and Bondžić, Aleksandra M. and Kortz, U. and Vasić, Vesna M. and Krstić, Danijela Z.",
year = "2016",
abstract = "The in  vitroinfluence  of  five  polyoxotungstates  containing  various  central atoms    on    acetylcholinesterase    (AChE)    activity    was    investigated. K6[PV3W9O40] × 3H2O, K6H2[TiW11CoO40] × 13H2O, (NH4)14[NaP5W30O110]    ×    31H2O,    K7[SiV3W9O40]    ×    10H2O,    and K7[Ti2PW10O40]   induced   the   enzyme   inhibition   in   a   concentration-dependent  manner.  Inhibitory  power  of  the  investigated  compounds  was evaluated  using  IC50values.  K7[SiV3W9O40]  ×  10H2O  affected  AChE activity with lowest potency (IC50 = 4.80 × 10-4mol/L). K6H2[TiW11CoO40] ×  13H2O  and  K7[Ti2PW10O40]  exhibited  high  affinity  toward  the  enzyme, inducing half-maximuminhibition at micromolar concentrations (1.14 × 10-6and 1.04 × 10-6mol/L, respectively), while the same effect was achieved in the  presence  of  about  fifty  times  higher  concentration  of  K6[PV3W9O40]  × 3H2O.  Finally,  (NH4)14[NaP5W30O110]  ×  31H2O  was  foundas  the  most potent   inhibitor   of   AChE   activity   (IC50 = 6.36   ×   10-7mol/L),   and consequently the most promising candidate for the treatment of neurological diseases associated with acetylcholine leakage.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry",
title = "Modulation of acetylcholinesterase activity induced by polyoxotungstates",
pages = "451-454"
}
Čolović, M. B., Bondžić, A. M., Kortz, U., Vasić, V. M.,& Krstić, D. Z.. (2016). Modulation of acetylcholinesterase activity induced by polyoxotungstates. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 451-454.
Čolović MB, Bondžić AM, Kortz U, Vasić VM, Krstić DZ. Modulation of acetylcholinesterase activity induced by polyoxotungstates. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:451-454..
Čolović, Mirjana B., Bondžić, Aleksandra M., Kortz, U., Vasić, Vesna M., Krstić, Danijela Z., "Modulation of acetylcholinesterase activity induced by polyoxotungstates" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):451-454.

Effect of experimental variables onto Co2+ and Sr2+ sorption behavior in red mud-water suspensions

Milenković, Aleksandra S.; Smičiklas, Ivana D.; Šljivić-Ivanović, Marija Z.; Živković, Ljiljana; Vukelić, Nikola S.

(Taylor & Francis, 2016)

TY  - JOUR
AU  - Milenković, Aleksandra S.
AU  - Smičiklas, Ivana D.
AU  - Šljivić-Ivanović, Marija Z.
AU  - Živković, Ljiljana
AU  - Vukelić, Nikola S.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1072
AB  - The prospects of rinsed red mud (alumina production residue) utilization for liquid radioactive waste treatment have been investigated, with Co2+ and Sr2+ as model cations of radioactive elements. To evaluate the sorption effectiveness and corresponding binding mechanisms, the process was analyzed in batch conditions, by varying experimental conditions (pH, Co2+ and Sr2+ concentrations in single solutions and binary mixtures, contact time, and the concentration of competing cations and ligands common in liquid radioactive waste). Comparison of the Co2+ and Sr2+ sorption pH edges with the red mud isoelectric point has revealed that Co2+ removal took place at both positive and negative red mud surface, while Sr2+ sorption abruptly increased when the surface became negatively charged. The increase of initial cation content and pH resulted in increased equilibrium times and sorption capacity and decreased rate constants. From single metal solutions and various binary mixtures, Co2+ was sorbed more efficiently and selectively than Sr2+. While Sr2+ sorption was reduced by coexisting cations in the order Al3+ Ca2+ GT Na+ Cs+, removal of Co2+ was affected by Al3+ species and complexing agents (EDTA and citrate). Desorption of Co2+ was negligible in Ca2+ and Sr2+ containing media and in solutions with initial pH 4-7. Sr2+ desorption was generally more pronounced, especially at low pH and in the presence of Co2+. Collected macroscopic data signify that Co2+ sorption by red mud minerals occurred via strong chemical bonds, while Sr2+ was retained mainly by weaker ion-exchange or electrostatic interactions. Results indicate that the rinsed red mud represent an efficient, low-cost sorbent for Co2+ and Sr2+ immobilization.
PB  - Taylor & Francis
T2  - Journal of Environmental Science and Health. Part A: Toxic Hazardous Substances and Environmental Engineering
T1  - Effect of experimental variables onto Co2+ and Sr2+ sorption behavior in red mud-water suspensions
VL  - 51
IS  - 8
SP  - 679
EP  - 690
DO  - 10.1080/10934529.2016.1159884
ER  - 
@article{
author = "Milenković, Aleksandra S. and Smičiklas, Ivana D. and Šljivić-Ivanović, Marija Z. and Živković, Ljiljana and Vukelić, Nikola S.",
year = "2016",
abstract = "The prospects of rinsed red mud (alumina production residue) utilization for liquid radioactive waste treatment have been investigated, with Co2+ and Sr2+ as model cations of radioactive elements. To evaluate the sorption effectiveness and corresponding binding mechanisms, the process was analyzed in batch conditions, by varying experimental conditions (pH, Co2+ and Sr2+ concentrations in single solutions and binary mixtures, contact time, and the concentration of competing cations and ligands common in liquid radioactive waste). Comparison of the Co2+ and Sr2+ sorption pH edges with the red mud isoelectric point has revealed that Co2+ removal took place at both positive and negative red mud surface, while Sr2+ sorption abruptly increased when the surface became negatively charged. The increase of initial cation content and pH resulted in increased equilibrium times and sorption capacity and decreased rate constants. From single metal solutions and various binary mixtures, Co2+ was sorbed more efficiently and selectively than Sr2+. While Sr2+ sorption was reduced by coexisting cations in the order Al3+ Ca2+ GT Na+ Cs+, removal of Co2+ was affected by Al3+ species and complexing agents (EDTA and citrate). Desorption of Co2+ was negligible in Ca2+ and Sr2+ containing media and in solutions with initial pH 4-7. Sr2+ desorption was generally more pronounced, especially at low pH and in the presence of Co2+. Collected macroscopic data signify that Co2+ sorption by red mud minerals occurred via strong chemical bonds, while Sr2+ was retained mainly by weaker ion-exchange or electrostatic interactions. Results indicate that the rinsed red mud represent an efficient, low-cost sorbent for Co2+ and Sr2+ immobilization.",
publisher = "Taylor & Francis",
journal = "Journal of Environmental Science and Health. Part A: Toxic Hazardous Substances and Environmental Engineering",
title = "Effect of experimental variables onto Co2+ and Sr2+ sorption behavior in red mud-water suspensions",
volume = "51",
number = "8",
pages = "679-690",
doi = "10.1080/10934529.2016.1159884"
}
Milenković, A. S., Smičiklas, I. D., Šljivić-Ivanović, M. Z., Živković, L.,& Vukelić, N. S.. (2016). Effect of experimental variables onto Co2+ and Sr2+ sorption behavior in red mud-water suspensions. in Journal of Environmental Science and Health. Part A: Toxic Hazardous Substances and Environmental Engineering
Taylor & Francis., 51(8), 679-690.
https://doi.org/10.1080/10934529.2016.1159884
Milenković AS, Smičiklas ID, Šljivić-Ivanović MZ, Živković L, Vukelić NS. Effect of experimental variables onto Co2+ and Sr2+ sorption behavior in red mud-water suspensions. in Journal of Environmental Science and Health. Part A: Toxic Hazardous Substances and Environmental Engineering. 2016;51(8):679-690.
doi:10.1080/10934529.2016.1159884 .
Milenković, Aleksandra S., Smičiklas, Ivana D., Šljivić-Ivanović, Marija Z., Živković, Ljiljana, Vukelić, Nikola S., "Effect of experimental variables onto Co2+ and Sr2+ sorption behavior in red mud-water suspensions" in Journal of Environmental Science and Health. Part A: Toxic Hazardous Substances and Environmental Engineering, 51, no. 8 (2016):679-690,
https://doi.org/10.1080/10934529.2016.1159884 . .
8
8
11

The role of different minerals from red mud assemblage in Co(II) sorption mechanism

Milenković, Aleksandra S.; Smičiklas, Ivana D.; Bundaleski, Nenad; Teodoro, Orlando M. N. D.; Veljović, Đorđe N.; Vukelić, Nikola S.

(2016)

TY  - JOUR
AU  - Milenković, Aleksandra S.
AU  - Smičiklas, Ivana D.
AU  - Bundaleski, Nenad
AU  - Teodoro, Orlando M. N. D.
AU  - Veljović, Đorđe N.
AU  - Vukelić, Nikola S.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1266
AB  - A range of industrial by-products are currently under the consideration as cost-effective alternatives to conventional sorbent materials for environmental clean-up and remediation applications. Bauxite residue (red mud) has demonstrated exceptionally high potential for the immobilization of cationic pollutants. Due to heterogeneity of such material, determination of the role of individual mineral phases in the overall sorption mechanism is a challenging task. To enlighten the mechanism of Co(II) sorption by mineral assemblage of the red mud, sequential extraction analysis of Co-loaded sample was combined with the microscopic and spectroscopic studies performed by Scanning Field Emission Electron Microscope (FE-SEM), Energy Dispersive Spectroscopy (EDS) and X-ray Photoelectron Spectroscopy (XPS). Sorbed Co(II) ions were found associated with operationally defined Fe,Mn-oxide and carbonate/acid soluble fractions. Binding of Co(II) by the red mud was achieved primarily by means of chemisorption/surface precipitation on Fe- and Ti-oxides. In coexistence with these highly selective surfaces, gibbsite and silica appeared to be low affinity sites for Co(II). Incongruent dissolution of sodalite phase was detected, indicating that its function was not to ensure sorption centers, but to increase the solution pH creating favorable environment for Co(II) binding by Fe- and Ti-oxides. The results demonstrate high stability of sorbed Co(II) and synergistic action of mineral constituents as essentially important property for red mud implementation as a purifying and remediation agent. (C) 2016 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. A: Physicochemical and Engineering Aspects
T1  - The role of different minerals from red mud assemblage in Co(II) sorption mechanism
VL  - 508
SP  - 8
EP  - 20
DO  - 10.1016/j.colsurfa.2016.08.011
ER  - 
@article{
author = "Milenković, Aleksandra S. and Smičiklas, Ivana D. and Bundaleski, Nenad and Teodoro, Orlando M. N. D. and Veljović, Đorđe N. and Vukelić, Nikola S.",
year = "2016",
abstract = "A range of industrial by-products are currently under the consideration as cost-effective alternatives to conventional sorbent materials for environmental clean-up and remediation applications. Bauxite residue (red mud) has demonstrated exceptionally high potential for the immobilization of cationic pollutants. Due to heterogeneity of such material, determination of the role of individual mineral phases in the overall sorption mechanism is a challenging task. To enlighten the mechanism of Co(II) sorption by mineral assemblage of the red mud, sequential extraction analysis of Co-loaded sample was combined with the microscopic and spectroscopic studies performed by Scanning Field Emission Electron Microscope (FE-SEM), Energy Dispersive Spectroscopy (EDS) and X-ray Photoelectron Spectroscopy (XPS). Sorbed Co(II) ions were found associated with operationally defined Fe,Mn-oxide and carbonate/acid soluble fractions. Binding of Co(II) by the red mud was achieved primarily by means of chemisorption/surface precipitation on Fe- and Ti-oxides. In coexistence with these highly selective surfaces, gibbsite and silica appeared to be low affinity sites for Co(II). Incongruent dissolution of sodalite phase was detected, indicating that its function was not to ensure sorption centers, but to increase the solution pH creating favorable environment for Co(II) binding by Fe- and Ti-oxides. The results demonstrate high stability of sorbed Co(II) and synergistic action of mineral constituents as essentially important property for red mud implementation as a purifying and remediation agent. (C) 2016 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects",
title = "The role of different minerals from red mud assemblage in Co(II) sorption mechanism",
volume = "508",
pages = "8-20",
doi = "10.1016/j.colsurfa.2016.08.011"
}
Milenković, A. S., Smičiklas, I. D., Bundaleski, N., Teodoro, O. M. N. D., Veljović, Đ. N.,& Vukelić, N. S.. (2016). The role of different minerals from red mud assemblage in Co(II) sorption mechanism. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 508, 8-20.
https://doi.org/10.1016/j.colsurfa.2016.08.011
Milenković AS, Smičiklas ID, Bundaleski N, Teodoro OMND, Veljović ĐN, Vukelić NS. The role of different minerals from red mud assemblage in Co(II) sorption mechanism. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects. 2016;508:8-20.
doi:10.1016/j.colsurfa.2016.08.011 .
Milenković, Aleksandra S., Smičiklas, Ivana D., Bundaleski, Nenad, Teodoro, Orlando M. N. D., Veljović, Đorđe N., Vukelić, Nikola S., "The role of different minerals from red mud assemblage in Co(II) sorption mechanism" in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 508 (2016):8-20,
https://doi.org/10.1016/j.colsurfa.2016.08.011 . .
10
10
12

Evaluation study of cobalt(II) and strontium(II) sorption-desorption behavior for selection of soil remediation technology

Smičiklas, Ivana D.; Dimović, Slavko; Jović, Mihajlo D.; Milenković, Aleksandra S.; Šljivić-Ivanović, Marija Z.

(Springer, 2015)

TY  - JOUR
AU  - Smičiklas, Ivana D.
AU  - Dimović, Slavko
AU  - Jović, Mihajlo D.
AU  - Milenković, Aleksandra S.
AU  - Šljivić-Ivanović, Marija Z.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/836
AB  - Sorption-desorption properties of cobalt(II) and strontium(II) ions were studied using a soil sample from the vicinity of the Serbian radioactive waste processing and interim storage facilities. The mobility of the cations in the soil was evaluated and compared with the intention to facilitate the selection of optimal remediation strategy in case of accidental soil contamination with radioactive cobalt-60 and strontium-90 isotopes. A systematic sorption study was performed through a series of batch experiments at different aging times, cation concentrations and pH. Kinetics experiments revealed that sorbed amounts of cobalt(II) continuously increased with contact time until quasi-equilibrium was reached, while initial fast strontium( II) sorption was followed by a desorption step. Based on the shapes of the sorption isotherms and calculated sorption parameters, it was concluded that cobalt(II) sorbed more selectively and strongly than strontium(II). Sequential extraction showed that, regardless of the initial content of contaminants in the soil and the aging time, high amounts of both cations were bonded to relatively mobile fractions: strontium(II) in the exchangeable, while cobalt( II) in the carbonate and ferromanganese oxide fraction. Strontium(II) was readily desorbed in acidic, calcium(II) and ethylenediaminetetraacetic acid-containing media, whereas complexing agents such as citric and tartaric acids at low pH were more effective reagents for cobalt(II) desorption. The results from the present study indicate that chemical extraction can be considered as remediation option for strontium(II)- and cobalt(II)-contaminated soil.
PB  - Springer
T2  - International Journal of Environmental Science and Technology
T1  - Evaluation study of cobalt(II) and strontium(II) sorption-desorption behavior for selection of soil remediation technology
VL  - 12
IS  - 12
SP  - 3853
EP  - 3862
DO  - 10.1007/s13762-015-0817-y
ER  - 
@article{
author = "Smičiklas, Ivana D. and Dimović, Slavko and Jović, Mihajlo D. and Milenković, Aleksandra S. and Šljivić-Ivanović, Marija Z.",
year = "2015",
abstract = "Sorption-desorption properties of cobalt(II) and strontium(II) ions were studied using a soil sample from the vicinity of the Serbian radioactive waste processing and interim storage facilities. The mobility of the cations in the soil was evaluated and compared with the intention to facilitate the selection of optimal remediation strategy in case of accidental soil contamination with radioactive cobalt-60 and strontium-90 isotopes. A systematic sorption study was performed through a series of batch experiments at different aging times, cation concentrations and pH. Kinetics experiments revealed that sorbed amounts of cobalt(II) continuously increased with contact time until quasi-equilibrium was reached, while initial fast strontium( II) sorption was followed by a desorption step. Based on the shapes of the sorption isotherms and calculated sorption parameters, it was concluded that cobalt(II) sorbed more selectively and strongly than strontium(II). Sequential extraction showed that, regardless of the initial content of contaminants in the soil and the aging time, high amounts of both cations were bonded to relatively mobile fractions: strontium(II) in the exchangeable, while cobalt( II) in the carbonate and ferromanganese oxide fraction. Strontium(II) was readily desorbed in acidic, calcium(II) and ethylenediaminetetraacetic acid-containing media, whereas complexing agents such as citric and tartaric acids at low pH were more effective reagents for cobalt(II) desorption. The results from the present study indicate that chemical extraction can be considered as remediation option for strontium(II)- and cobalt(II)-contaminated soil.",
publisher = "Springer",
journal = "International Journal of Environmental Science and Technology",
title = "Evaluation study of cobalt(II) and strontium(II) sorption-desorption behavior for selection of soil remediation technology",
volume = "12",
number = "12",
pages = "3853-3862",
doi = "10.1007/s13762-015-0817-y"
}
Smičiklas, I. D., Dimović, S., Jović, M. D., Milenković, A. S.,& Šljivić-Ivanović, M. Z.. (2015). Evaluation study of cobalt(II) and strontium(II) sorption-desorption behavior for selection of soil remediation technology. in International Journal of Environmental Science and Technology
Springer., 12(12), 3853-3862.
https://doi.org/10.1007/s13762-015-0817-y
Smičiklas ID, Dimović S, Jović MD, Milenković AS, Šljivić-Ivanović MZ. Evaluation study of cobalt(II) and strontium(II) sorption-desorption behavior for selection of soil remediation technology. in International Journal of Environmental Science and Technology. 2015;12(12):3853-3862.
doi:10.1007/s13762-015-0817-y .
Smičiklas, Ivana D., Dimović, Slavko, Jović, Mihajlo D., Milenković, Aleksandra S., Šljivić-Ivanović, Marija Z., "Evaluation study of cobalt(II) and strontium(II) sorption-desorption behavior for selection of soil remediation technology" in International Journal of Environmental Science and Technology, 12, no. 12 (2015):3853-3862,
https://doi.org/10.1007/s13762-015-0817-y . .
11
14
13

Concurrent Co2+ and Sr2+ sorption from binary mixtures using aluminum industry waste: Kinetic study

Milenković, Aleksandra S.; Smičiklas, Ivana D.; Šljivić-Ivanović, Marija Z.; Vukelić, Nikola S.

(Springer Nature, 2015)

TY  - JOUR
AU  - Milenković, Aleksandra S.
AU  - Smičiklas, Ivana D.
AU  - Šljivić-Ivanović, Marija Z.
AU  - Vukelić, Nikola S.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/813
AB  - Multi-component sorption studies are essential to identify the applicability of red mud as a lowcost sorbent for the simultaneous removal of metal ions from wastewaters. Sorption kinetics of Co2+ and Sr2+ ions was investigated, at different total concentrations of mixtures and different molar ratios of two cations. Kinetics of metal sorption from binary systems was found to be well described by pseudo-second order rate model. Equilibrium sorbed amounts and equilibrium times for Co2+ sorption increased with the increase of its total concentration in the mixture, whereas pseudo-second order rate constants exhibited the opposite trend. Sr2+ sorption was strongly suppressed in the presence of Co2+ ions, and the removal efficiency decreased with increasing concentration and mole fraction of Co2+. Red mud can be used for simultaneous Co2+ and Sr2+ removal from mixtures of lower initial concentration, otherwise Co2+ sorption is dominant.
PB  - Springer Nature
T2  - Russian Journal of Physical Chemistry A
T1  - Concurrent Co2+ and Sr2+ sorption from binary mixtures using aluminum industry waste: Kinetic study
VL  - 89
IS  - 13
SP  - 2461
EP  - 2465
DO  - 10.1134/S0036024415130269
ER  - 
@article{
author = "Milenković, Aleksandra S. and Smičiklas, Ivana D. and Šljivić-Ivanović, Marija Z. and Vukelić, Nikola S.",
year = "2015",
abstract = "Multi-component sorption studies are essential to identify the applicability of red mud as a lowcost sorbent for the simultaneous removal of metal ions from wastewaters. Sorption kinetics of Co2+ and Sr2+ ions was investigated, at different total concentrations of mixtures and different molar ratios of two cations. Kinetics of metal sorption from binary systems was found to be well described by pseudo-second order rate model. Equilibrium sorbed amounts and equilibrium times for Co2+ sorption increased with the increase of its total concentration in the mixture, whereas pseudo-second order rate constants exhibited the opposite trend. Sr2+ sorption was strongly suppressed in the presence of Co2+ ions, and the removal efficiency decreased with increasing concentration and mole fraction of Co2+. Red mud can be used for simultaneous Co2+ and Sr2+ removal from mixtures of lower initial concentration, otherwise Co2+ sorption is dominant.",
publisher = "Springer Nature",
journal = "Russian Journal of Physical Chemistry A",
title = "Concurrent Co2+ and Sr2+ sorption from binary mixtures using aluminum industry waste: Kinetic study",
volume = "89",
number = "13",
pages = "2461-2465",
doi = "10.1134/S0036024415130269"
}
Milenković, A. S., Smičiklas, I. D., Šljivić-Ivanović, M. Z.,& Vukelić, N. S.. (2015). Concurrent Co2+ and Sr2+ sorption from binary mixtures using aluminum industry waste: Kinetic study. in Russian Journal of Physical Chemistry A
Springer Nature., 89(13), 2461-2465.
https://doi.org/10.1134/S0036024415130269
Milenković AS, Smičiklas ID, Šljivić-Ivanović MZ, Vukelić NS. Concurrent Co2+ and Sr2+ sorption from binary mixtures using aluminum industry waste: Kinetic study. in Russian Journal of Physical Chemistry A. 2015;89(13):2461-2465.
doi:10.1134/S0036024415130269 .
Milenković, Aleksandra S., Smičiklas, Ivana D., Šljivić-Ivanović, Marija Z., Vukelić, Nikola S., "Concurrent Co2+ and Sr2+ sorption from binary mixtures using aluminum industry waste: Kinetic study" in Russian Journal of Physical Chemistry A, 89, no. 13 (2015):2461-2465,
https://doi.org/10.1134/S0036024415130269 . .
2
2
2

Evaluation of the effects of treatment factors on the properties of bio-apatite materials

Šljivić-Ivanović, Marija Z.; Smičiklas, Ivana D.; Milenković, Aleksandra S.; Dojčinović, Biljana P.; Babić, Biljana M.; Mitrić, Miodrag

(2015)

TY  - JOUR
AU  - Šljivić-Ivanović, Marija Z.
AU  - Smičiklas, Ivana D.
AU  - Milenković, Aleksandra S.
AU  - Dojčinović, Biljana P.
AU  - Babić, Biljana M.
AU  - Mitrić, Miodrag
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/214
AB  - Animal bones have been studied as a resource of low-crystalline apatite for immobilization of toxic heavy metals. Chemical and thermal treatments can be applied for selective removal of bone organic constituents. In this study, the impact of different treatment factors was determined by experimental design methodology, and comparison of the estimated effects was performed in order to optimize the treatment conditions. Fractional factorial design with five variables at two levels was applied for factors screening. The type of chemical reagent (H2O2 or NaOH), its concentration (0.1 or 2 mol/L), reaction temperature (20 or 60 degrees C), contact time (1 or 3 h) and sample annealing (without or at 400 degrees C) were considered as process variables. Structural properties of bone sorbents, loss of ignition, point of zero charge, surface functional groups, specific surface area, chemical composition, and Cd2+ sorption efficiency, were selected as system responses. Samples significantly differed in respect to the organic phase content and composition, thus mechanisms of Cd2+ sorption were complex. Statistical analysis has revealed that, between all studied factors, temperature treatment was the most important for sorbents increased specific surface area, porosity and cation sorption. Furthermore, NaOH was more effective than H2O2, while the effects produced by variation of other factors were less pronounced. The highest proportion of bio-apatite with desired low crystallinity and high specific surface area was achieved by synergetic effects of chemical treatment with NaOH and thermal treatment at 400 degrees C.
T2  - Journal of Materials Science
T1  - Evaluation of the effects of treatment factors on the properties of bio-apatite materials
VL  - 50
IS  - 1
SP  - 354
EP  - 365
DO  - 10.1007/s10853-014-8594-4
ER  - 
@article{
author = "Šljivić-Ivanović, Marija Z. and Smičiklas, Ivana D. and Milenković, Aleksandra S. and Dojčinović, Biljana P. and Babić, Biljana M. and Mitrić, Miodrag",
year = "2015",
abstract = "Animal bones have been studied as a resource of low-crystalline apatite for immobilization of toxic heavy metals. Chemical and thermal treatments can be applied for selective removal of bone organic constituents. In this study, the impact of different treatment factors was determined by experimental design methodology, and comparison of the estimated effects was performed in order to optimize the treatment conditions. Fractional factorial design with five variables at two levels was applied for factors screening. The type of chemical reagent (H2O2 or NaOH), its concentration (0.1 or 2 mol/L), reaction temperature (20 or 60 degrees C), contact time (1 or 3 h) and sample annealing (without or at 400 degrees C) were considered as process variables. Structural properties of bone sorbents, loss of ignition, point of zero charge, surface functional groups, specific surface area, chemical composition, and Cd2+ sorption efficiency, were selected as system responses. Samples significantly differed in respect to the organic phase content and composition, thus mechanisms of Cd2+ sorption were complex. Statistical analysis has revealed that, between all studied factors, temperature treatment was the most important for sorbents increased specific surface area, porosity and cation sorption. Furthermore, NaOH was more effective than H2O2, while the effects produced by variation of other factors were less pronounced. The highest proportion of bio-apatite with desired low crystallinity and high specific surface area was achieved by synergetic effects of chemical treatment with NaOH and thermal treatment at 400 degrees C.",
journal = "Journal of Materials Science",
title = "Evaluation of the effects of treatment factors on the properties of bio-apatite materials",
volume = "50",
number = "1",
pages = "354-365",
doi = "10.1007/s10853-014-8594-4"
}
Šljivić-Ivanović, M. Z., Smičiklas, I. D., Milenković, A. S., Dojčinović, B. P., Babić, B. M.,& Mitrić, M.. (2015). Evaluation of the effects of treatment factors on the properties of bio-apatite materials. in Journal of Materials Science, 50(1), 354-365.
https://doi.org/10.1007/s10853-014-8594-4
Šljivić-Ivanović MZ, Smičiklas ID, Milenković AS, Dojčinović BP, Babić BM, Mitrić M. Evaluation of the effects of treatment factors on the properties of bio-apatite materials. in Journal of Materials Science. 2015;50(1):354-365.
doi:10.1007/s10853-014-8594-4 .
Šljivić-Ivanović, Marija Z., Smičiklas, Ivana D., Milenković, Aleksandra S., Dojčinović, Biljana P., Babić, Biljana M., Mitrić, Miodrag, "Evaluation of the effects of treatment factors on the properties of bio-apatite materials" in Journal of Materials Science, 50, no. 1 (2015):354-365,
https://doi.org/10.1007/s10853-014-8594-4 . .
8
10
11

Immobilization of Co-60 and Sr-90 Ions Using Red Mud from Aluminum Industry

Milenković, Aleksandra S.; Smičiklas, Ivana D.; Marković, Jelena P.; Vukelić, Nikola S.

(2014)

TY  - JOUR
AU  - Milenković, Aleksandra S.
AU  - Smičiklas, Ivana D.
AU  - Marković, Jelena P.
AU  - Vukelić, Nikola S.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5973
AB  - The removal of Co-60 and Sr-90 from the aqueous phase was tested using red mud - the fine grained residue from bauxite ore processing. This industrial waste represents a mixture of numerous minerals, mainly oxides and hydroxides of Fe, Al, Si, and Ti. Experiments were conducted as a function of contact time, pH, and pollutant concentrations. Kinetic data were well fitted with a pseudo-second order equation. The calculated rate constants and initial sorption rates indicated faster sorption of Sr2+ ions. Removal of both cations rapidly increased with the initial pH increase from 2.5 to 3.5. With the further increase of pH, Co2+ sorption was nearly constant (98%-100%), whereas Sr2+ removal remained at the same level to initial pH similar to 8 and gradually increased to 100% at pH 12. Equilibrium sorption data followed the Langmuir model, with the maximum sorption capacities of 0.52 mmol/g for Co2+ and 0.31 mmol/g for Sr2+. Sorbed cations exhibited high stability in distilled water. Desorption of Co2+ was also negligible in the presence of the competing Ca2+ cation, while 42%-25% of Sr2+ ions were desorbed depending on the previously sorbed amount. The results indicate that red mud is of potential significance as Co2+ and Sr2+ immobilization agent due to its high efficiency, abundance, and low-cost.
T2  - Nuclear technology and radiation protection
T1  - Immobilization of Co-60 and Sr-90 Ions Using Red Mud from Aluminum Industry
VL  - 29
IS  - 1
SP  - 79
EP  - 87
DO  - 10.2298/NTRP1401079M
ER  - 
@article{
author = "Milenković, Aleksandra S. and Smičiklas, Ivana D. and Marković, Jelena P. and Vukelić, Nikola S.",
year = "2014",
abstract = "The removal of Co-60 and Sr-90 from the aqueous phase was tested using red mud - the fine grained residue from bauxite ore processing. This industrial waste represents a mixture of numerous minerals, mainly oxides and hydroxides of Fe, Al, Si, and Ti. Experiments were conducted as a function of contact time, pH, and pollutant concentrations. Kinetic data were well fitted with a pseudo-second order equation. The calculated rate constants and initial sorption rates indicated faster sorption of Sr2+ ions. Removal of both cations rapidly increased with the initial pH increase from 2.5 to 3.5. With the further increase of pH, Co2+ sorption was nearly constant (98%-100%), whereas Sr2+ removal remained at the same level to initial pH similar to 8 and gradually increased to 100% at pH 12. Equilibrium sorption data followed the Langmuir model, with the maximum sorption capacities of 0.52 mmol/g for Co2+ and 0.31 mmol/g for Sr2+. Sorbed cations exhibited high stability in distilled water. Desorption of Co2+ was also negligible in the presence of the competing Ca2+ cation, while 42%-25% of Sr2+ ions were desorbed depending on the previously sorbed amount. The results indicate that red mud is of potential significance as Co2+ and Sr2+ immobilization agent due to its high efficiency, abundance, and low-cost.",
journal = "Nuclear technology and radiation protection",
title = "Immobilization of Co-60 and Sr-90 Ions Using Red Mud from Aluminum Industry",
volume = "29",
number = "1",
pages = "79-87",
doi = "10.2298/NTRP1401079M"
}
Milenković, A. S., Smičiklas, I. D., Marković, J. P.,& Vukelić, N. S.. (2014). Immobilization of Co-60 and Sr-90 Ions Using Red Mud from Aluminum Industry. in Nuclear technology and radiation protection, 29(1), 79-87.
https://doi.org/10.2298/NTRP1401079M
Milenković AS, Smičiklas ID, Marković JP, Vukelić NS. Immobilization of Co-60 and Sr-90 Ions Using Red Mud from Aluminum Industry. in Nuclear technology and radiation protection. 2014;29(1):79-87.
doi:10.2298/NTRP1401079M .
Milenković, Aleksandra S., Smičiklas, Ivana D., Marković, Jelena P., Vukelić, Nikola S., "Immobilization of Co-60 and Sr-90 Ions Using Red Mud from Aluminum Industry" in Nuclear technology and radiation protection, 29, no. 1 (2014):79-87,
https://doi.org/10.2298/NTRP1401079M . .
9
11

Comparison of various bovine bone treatments for the preparation of effective Ni(ii) sorbent material

Šljivić-Ivanović, Marija Z.; Milenković, Aleksandra S.; Jović, Mihajlo D.; Smičiklas, Ivana D.

(Society of Physical Chemists of Serbia, 2014)

TY  - CONF
AU  - Šljivić-Ivanović, Marija Z.
AU  - Milenković, Aleksandra S.
AU  - Jović, Mihajlo D.
AU  - Smičiklas, Ivana D.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9246
AB  - Animal bones are reach source of calcium hydroxyapatite which was
approved as a good sorbent material for heavy metals and radionuclides.
Various treatments can reduce the content of bone organic phase and
improve sorption properties. In this study sorption capacities of raw bovine
bones (B) and samples obtained by chemical treatment using NaOH
(BNaOH), by heating at 400 oC (B400) or by combined chemical and thermal
treatment (BNaOH+400), were compared. It was shown that sorbents exhibited
different sorption mechanisms towards Ni(II) ions, and that maximum
sorption capacities increased in the order B<BNaOH<B400<BNaOH+400.
Synergetic effect of chemical and thermal treatment produced the material
with highest sorption efficiency.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Comparison of various bovine bone treatments for the preparation of effective Ni(ii) sorbent material
VL  - K-16-P
ER  - 
@conference{
author = "Šljivić-Ivanović, Marija Z. and Milenković, Aleksandra S. and Jović, Mihajlo D. and Smičiklas, Ivana D.",
year = "2014",
abstract = "Animal bones are reach source of calcium hydroxyapatite which was
approved as a good sorbent material for heavy metals and radionuclides.
Various treatments can reduce the content of bone organic phase and
improve sorption properties. In this study sorption capacities of raw bovine
bones (B) and samples obtained by chemical treatment using NaOH
(BNaOH), by heating at 400 oC (B400) or by combined chemical and thermal
treatment (BNaOH+400), were compared. It was shown that sorbents exhibited
different sorption mechanisms towards Ni(II) ions, and that maximum
sorption capacities increased in the order B<BNaOH<B400<BNaOH+400.
Synergetic effect of chemical and thermal treatment produced the material
with highest sorption efficiency.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Comparison of various bovine bone treatments for the preparation of effective Ni(ii) sorbent material",
volume = "K-16-P"
}
Šljivić-Ivanović, M. Z., Milenković, A. S., Jović, M. D.,& Smičiklas, I. D.. (2014). Comparison of various bovine bone treatments for the preparation of effective Ni(ii) sorbent material. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., K-16-P.
Šljivić-Ivanović MZ, Milenković AS, Jović MD, Smičiklas ID. Comparison of various bovine bone treatments for the preparation of effective Ni(ii) sorbent material. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;K-16-P..
Šljivić-Ivanović, Marija Z., Milenković, Aleksandra S., Jović, Mihajlo D., Smičiklas, Ivana D., "Comparison of various bovine bone treatments for the preparation of effective Ni(ii) sorbent material" in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, K-16-P (2014).

Kinetic study of competitive CO2+ and Sr2+sorption by bauxite residue

Milenković, Aleksandra S.; Smičiklas, Ivana D.; Šljivić-Ivanović, Marija Z.; Vukelić, Nikola

(Society of Physical Chemists of Serbia, 2014)

TY  - CONF
AU  - Milenković, Aleksandra S.
AU  - Smičiklas, Ivana D.
AU  - Šljivić-Ivanović, Marija Z.
AU  - Vukelić, Nikola
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9188
AB  - Multi-component sorption studies are essential to identify the applicability
of red mud as a low-cost sorbent for the simultaneous removal of metal ions
from wastewaters. Sorption kinetics of Co2+ and Sr2+ionswas studied, at
their different molar ratios in the mixture. The pseudo-second-order rate
model best described the kinetics of metal sorption from binary metal
systems. The increase of initial concentration of each cationin the mixture
provoked its increased sorption capacity, but decreased sorption rate.
Co2+sorption was superior in terms of both the rate and the capacity,
therefore exertedstrong inhibitory effect on Sr2+sorption.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Kinetic study of competitive CO2+ and Sr2+sorption by bauxite residue
VL  - C-19-P
ER  - 
@conference{
author = "Milenković, Aleksandra S. and Smičiklas, Ivana D. and Šljivić-Ivanović, Marija Z. and Vukelić, Nikola",
year = "2014",
abstract = "Multi-component sorption studies are essential to identify the applicability
of red mud as a low-cost sorbent for the simultaneous removal of metal ions
from wastewaters. Sorption kinetics of Co2+ and Sr2+ionswas studied, at
their different molar ratios in the mixture. The pseudo-second-order rate
model best described the kinetics of metal sorption from binary metal
systems. The increase of initial concentration of each cationin the mixture
provoked its increased sorption capacity, but decreased sorption rate.
Co2+sorption was superior in terms of both the rate and the capacity,
therefore exertedstrong inhibitory effect on Sr2+sorption.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Kinetic study of competitive CO2+ and Sr2+sorption by bauxite residue",
volume = "C-19-P"
}
Milenković, A. S., Smičiklas, I. D., Šljivić-Ivanović, M. Z.,& Vukelić, N.. (2014). Kinetic study of competitive CO2+ and Sr2+sorption by bauxite residue. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., C-19-P.
Milenković AS, Smičiklas ID, Šljivić-Ivanović MZ, Vukelić N. Kinetic study of competitive CO2+ and Sr2+sorption by bauxite residue. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;C-19-P..
Milenković, Aleksandra S., Smičiklas, Ivana D., Šljivić-Ivanović, Marija Z., Vukelić, Nikola, "Kinetic study of competitive CO2+ and Sr2+sorption by bauxite residue" in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, C-19-P (2014).

Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection

Lazarević-Pašti, Tamara; Bondžić, Aleksandra M.; Pašti, Igor A.; Mentus, Slavko V.; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Bondžić, Aleksandra M.
AU  - Pašti, Igor A.
AU  - Mentus, Slavko V.
AU  - Vasić, Vesna M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5410
AB  - Organophosphorous pesticide diazinon was indirectly oxidized to diazoxon by means of electrogenerated Cl-2, Br-2 or I-2 under galvanostatic conditions using rotating glassy carbon disk electrode. The rate of oxidation was the highest in the case of electrogenerated Br-2. In the presence of electrogenerated Br-2 diazinon was completely converted to diazoxon after 15 min of electrochemical treatment at all concentrations investigated. On the basis of thermodynamic and kinetic arguments it was showed that diazinon oxidation is governed by both kinetics and speciation of halogen species. Diazoxon is rapidly formed during its reaction with active oxidant species, while formed diazoxon is being stable and not degraded at appreciable rate by reactive halogen species. Described oxidation procedure was used as a pre-step for diazinon detection using AChE test coupled with optical detection. Diazinon detection limit was reduced by three orders of magnitude compared to unoxidized diazinon. This enabled diazinon detection at the lowest possible concentration using described methodology, as determined by diazoxon detection limit. (C) 2013 Elsevier B.V. All rights reserved.
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection
VL  - 692
SP  - 40
EP  - 45
DO  - 10.1016/j.jelechem.2013.01.005
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Bondžić, Aleksandra M. and Pašti, Igor A. and Mentus, Slavko V. and Vasić, Vesna M.",
year = "2013",
abstract = "Organophosphorous pesticide diazinon was indirectly oxidized to diazoxon by means of electrogenerated Cl-2, Br-2 or I-2 under galvanostatic conditions using rotating glassy carbon disk electrode. The rate of oxidation was the highest in the case of electrogenerated Br-2. In the presence of electrogenerated Br-2 diazinon was completely converted to diazoxon after 15 min of electrochemical treatment at all concentrations investigated. On the basis of thermodynamic and kinetic arguments it was showed that diazinon oxidation is governed by both kinetics and speciation of halogen species. Diazoxon is rapidly formed during its reaction with active oxidant species, while formed diazoxon is being stable and not degraded at appreciable rate by reactive halogen species. Described oxidation procedure was used as a pre-step for diazinon detection using AChE test coupled with optical detection. Diazinon detection limit was reduced by three orders of magnitude compared to unoxidized diazinon. This enabled diazinon detection at the lowest possible concentration using described methodology, as determined by diazoxon detection limit. (C) 2013 Elsevier B.V. All rights reserved.",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection",
volume = "692",
pages = "40-45",
doi = "10.1016/j.jelechem.2013.01.005"
}
Lazarević-Pašti, T., Bondžić, A. M., Pašti, I. A., Mentus, S. V.,& Vasić, V. M.. (2013). Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection. in Journal of Electroanalytical Chemistry, 692, 40-45.
https://doi.org/10.1016/j.jelechem.2013.01.005
Lazarević-Pašti T, Bondžić AM, Pašti IA, Mentus SV, Vasić VM. Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection. in Journal of Electroanalytical Chemistry. 2013;692:40-45.
doi:10.1016/j.jelechem.2013.01.005 .
Lazarević-Pašti, Tamara, Bondžić, Aleksandra M., Pašti, Igor A., Mentus, Slavko V., Vasić, Vesna M., "Electrochemical oxidation of diazinon in aqueous solutions via electrogenerated halogens - Diazinon fate and implications for its detection" in Journal of Electroanalytical Chemistry, 692 (2013):40-45,
https://doi.org/10.1016/j.jelechem.2013.01.005 . .
19
16
21

Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products

Bondžić, Aleksandra M.; Lazarević-Pašti, Tamara; Bondzic, Bojan P.; Čolović, Mirjana B.; Jadranin, Milka B.; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Lazarević-Pašti, Tamara
AU  - Bondzic, Bojan P.
AU  - Čolović, Mirjana B.
AU  - Jadranin, Milka B.
AU  - Vasić, Vesna M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5362
AB  - The aim of the present paper was to investigate the reaction of quercetin, the flavonol very often used as a dietary supplement, with [AuCl4](-) ions. The reaction was studied spectrophotometrically using the equimolar solutions in 1 : 1 water-methanol at pH similar to 2. The spectrophotometric data indicated the formation of the products with an absorption maximum at 295 nm in all cases, characteristic of the oxidized forms of quercetin. HPLC coupled with DAD and LC-MS analysis of the reaction products suggested that the oxidation of quercetin resulted in the generation of similar metabolites including quinone and various oxidized quercetin-solvent adducts. In addition, cyclic voltammetric measurements confirmed that under applied experimental conditions, the reduction of Au(III) to Au(0) took place. The reduction species in the reaction mixture were Au(III) ions, while Au(I) disproportionates back to Au(III) and Au(0). The newly generated Au(III) ions further oxidized 3-4-dihydroxy groups of quercetin adducts obtained after first 2e(-) oxidation, giving the final reaction products. Based on the identification of reaction products, the reaction mechanism for the oxidation of quercetin in the presence of Au(III) which involves two 2e(-) transfer processes was proposed.
T2  - New Journal of Chemistry
T1  - Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products
VL  - 37
IS  - 4
SP  - 901
EP  - 908
DO  - 10.1039/c2nj40742f
ER  - 
@article{
author = "Bondžić, Aleksandra M. and Lazarević-Pašti, Tamara and Bondzic, Bojan P. and Čolović, Mirjana B. and Jadranin, Milka B. and Vasić, Vesna M.",
year = "2013",
abstract = "The aim of the present paper was to investigate the reaction of quercetin, the flavonol very often used as a dietary supplement, with [AuCl4](-) ions. The reaction was studied spectrophotometrically using the equimolar solutions in 1 : 1 water-methanol at pH similar to 2. The spectrophotometric data indicated the formation of the products with an absorption maximum at 295 nm in all cases, characteristic of the oxidized forms of quercetin. HPLC coupled with DAD and LC-MS analysis of the reaction products suggested that the oxidation of quercetin resulted in the generation of similar metabolites including quinone and various oxidized quercetin-solvent adducts. In addition, cyclic voltammetric measurements confirmed that under applied experimental conditions, the reduction of Au(III) to Au(0) took place. The reduction species in the reaction mixture were Au(III) ions, while Au(I) disproportionates back to Au(III) and Au(0). The newly generated Au(III) ions further oxidized 3-4-dihydroxy groups of quercetin adducts obtained after first 2e(-) oxidation, giving the final reaction products. Based on the identification of reaction products, the reaction mechanism for the oxidation of quercetin in the presence of Au(III) which involves two 2e(-) transfer processes was proposed.",
journal = "New Journal of Chemistry",
title = "Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products",
volume = "37",
number = "4",
pages = "901-908",
doi = "10.1039/c2nj40742f"
}
Bondžić, A. M., Lazarević-Pašti, T., Bondzic, B. P., Čolović, M. B., Jadranin, M. B.,& Vasić, V. M.. (2013). Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products. in New Journal of Chemistry, 37(4), 901-908.
https://doi.org/10.1039/c2nj40742f
Bondžić AM, Lazarević-Pašti T, Bondzic BP, Čolović MB, Jadranin MB, Vasić VM. Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products. in New Journal of Chemistry. 2013;37(4):901-908.
doi:10.1039/c2nj40742f .
Bondžić, Aleksandra M., Lazarević-Pašti, Tamara, Bondzic, Bojan P., Čolović, Mirjana B., Jadranin, Milka B., Vasić, Vesna M., "Investigation of reaction between quercetin and Au(III) in acidic media: mechanism and identification of reaction products" in New Journal of Chemistry, 37, no. 4 (2013):901-908,
https://doi.org/10.1039/c2nj40742f . .
13
15
16

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

Čolović, Mirjana B.; Krstić, Danijela Z.; Lazarević-Pašti, Tamara; Bondžić, Aleksandra M.; Vasić, Vesna M.

(2013)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Lazarević-Pašti, Tamara
AU  - Bondžić, Aleksandra M.
AU  - Vasić, Vesna M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5474
AB  - Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. In the case of reversible inhibitors being commonly applied in neurodegenerative disorders treatment, special attention is paid to currently approved drugs (donepezil, rivastigmine and galantamine) in the pharmacotherapy of Alzheimers disease, and toxic carbamates used as pesticides. Subsequently, mechanism of irreversible acetylcholinesterase inhibition induced by organophosphorus compounds (insecticides and nerve agents), and their specific and nonspecific toxic effects are described, as well as irreversible inhibitors having pharmacological implementation. In addition, the pharmacological treatment of intoxication caused by organophosphates is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning. Besides, organophosphorus and carbamate insecticides can be detoxified in mammals through enzymatic hydrolysis before they reach targets in the nervous system. Carboxylesterases most effectively decompose carbamates, whereas the most successful route of organophosphates detoxification is their degradation by corresponding phosphotriesterases.
T2  - Current Neuropharmacology
T1  - Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
VL  - 11
IS  - 3
SP  - 315
EP  - 335
DO  - 10.2174/1570159X11311030006
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Lazarević-Pašti, Tamara and Bondžić, Aleksandra M. and Vasić, Vesna M.",
year = "2013",
abstract = "Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. In the case of reversible inhibitors being commonly applied in neurodegenerative disorders treatment, special attention is paid to currently approved drugs (donepezil, rivastigmine and galantamine) in the pharmacotherapy of Alzheimers disease, and toxic carbamates used as pesticides. Subsequently, mechanism of irreversible acetylcholinesterase inhibition induced by organophosphorus compounds (insecticides and nerve agents), and their specific and nonspecific toxic effects are described, as well as irreversible inhibitors having pharmacological implementation. In addition, the pharmacological treatment of intoxication caused by organophosphates is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning. Besides, organophosphorus and carbamate insecticides can be detoxified in mammals through enzymatic hydrolysis before they reach targets in the nervous system. Carboxylesterases most effectively decompose carbamates, whereas the most successful route of organophosphates detoxification is their degradation by corresponding phosphotriesterases.",
journal = "Current Neuropharmacology",
title = "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology",
volume = "11",
number = "3",
pages = "315-335",
doi = "10.2174/1570159X11311030006"
}
Čolović, M. B., Krstić, D. Z., Lazarević-Pašti, T., Bondžić, A. M.,& Vasić, V. M.. (2013). Acetylcholinesterase Inhibitors: Pharmacology and Toxicology. in Current Neuropharmacology, 11(3), 315-335.
https://doi.org/10.2174/1570159X11311030006
Čolović MB, Krstić DZ, Lazarević-Pašti T, Bondžić AM, Vasić VM. Acetylcholinesterase Inhibitors: Pharmacology and Toxicology. in Current Neuropharmacology. 2013;11(3):315-335.
doi:10.2174/1570159X11311030006 .
Čolović, Mirjana B., Krstić, Danijela Z., Lazarević-Pašti, Tamara, Bondžić, Aleksandra M., Vasić, Vesna M., "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology" in Current Neuropharmacology, 11, no. 3 (2013):315-335,
https://doi.org/10.2174/1570159X11311030006 . .
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1113
1211

Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes

Čolović, Mirjana B.; Krstić, Danijela Z.; Vasić, Vesna M.; Bondžić, Aleksandra M.; Uscumlic, Gordana S.; Petrovic, Slobodan D.

(2013)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Vasić, Vesna M.
AU  - Bondžić, Aleksandra M.
AU  - Uscumlic, Gordana S.
AU  - Petrovic, Slobodan D.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5599
AB  - Organophosphorus insecticides have been the most applied group of insectcides for the last two decades. Their main toxic effects are related to irreversible inactivation of acetylcholinesterase (AChE). Actually, they covalently bind to serine OH group in the enzyme active site forming phosphorylated enzyme that cannot hydrolyze acetylcholine. Organophosphorus insecticides in the environment undergo the natural degradation pathway including mainly homogeneous and heterogeneous hydrolysis (especially at high pH) generating non-inhibiting products. Additionally, thio organophosphates are easily oxidized by naturally present oxidants and UV light, forming more toxic and stable oxons. Thus, oxidative degradation procedures, generally referred as advanced oxidation processes (AOP), have been applied for their efficient removal from contaminated waters. The most applied bioassays to monitor the organophosphate toxicity, i.e., the detoxification degree during AOP are Vibrio fischeri and AChE bioassays. Vibrio fischeri toxicity test exploits bioluminescence as the measure of luciferase activity of this marine bacterium, whereas AChE bioassay is based on AChE activity inhibition. Both bioanalytical techniques are rapid (several minutes), simple, sensitive and reproducible. Vibrio fischeri test seems to be a versatile indicator of toxic compounds generated in AOP for organophosphorus insecticides degradation. However, detection of neurotoxic AChE inhibitors, which can be formed in AOP of some organophosphates, requires AChE bioassays. Therefore, AChE toxicity test is more appropriate for monitoring the degradation processes of thio organophosphates, because more toxic oxo organophosphates might be formed and overlooked by Vibrio fischeri bioluminescence inhibition. In addition, during organophosphates removal by AOP, compounds with strong genotoxic potential may be formed, which cannot be detected by standard toxicity tests. For this reason, determination of incidence of micronuclei and cell proliferation index in cultivated human lymphocytes and fibroblasts is suitable for evaluation of organophosphorus insecticides and their break down products inducing cytogenetic damage.
T2  - Hemijska industrija
T1  - Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes
VL  - 67
IS  - 2
SP  - 217
EP  - 230
DO  - 10.2298/HEMIND120323060C
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Vasić, Vesna M. and Bondžić, Aleksandra M. and Uscumlic, Gordana S. and Petrovic, Slobodan D.",
year = "2013",
abstract = "Organophosphorus insecticides have been the most applied group of insectcides for the last two decades. Their main toxic effects are related to irreversible inactivation of acetylcholinesterase (AChE). Actually, they covalently bind to serine OH group in the enzyme active site forming phosphorylated enzyme that cannot hydrolyze acetylcholine. Organophosphorus insecticides in the environment undergo the natural degradation pathway including mainly homogeneous and heterogeneous hydrolysis (especially at high pH) generating non-inhibiting products. Additionally, thio organophosphates are easily oxidized by naturally present oxidants and UV light, forming more toxic and stable oxons. Thus, oxidative degradation procedures, generally referred as advanced oxidation processes (AOP), have been applied for their efficient removal from contaminated waters. The most applied bioassays to monitor the organophosphate toxicity, i.e., the detoxification degree during AOP are Vibrio fischeri and AChE bioassays. Vibrio fischeri toxicity test exploits bioluminescence as the measure of luciferase activity of this marine bacterium, whereas AChE bioassay is based on AChE activity inhibition. Both bioanalytical techniques are rapid (several minutes), simple, sensitive and reproducible. Vibrio fischeri test seems to be a versatile indicator of toxic compounds generated in AOP for organophosphorus insecticides degradation. However, detection of neurotoxic AChE inhibitors, which can be formed in AOP of some organophosphates, requires AChE bioassays. Therefore, AChE toxicity test is more appropriate for monitoring the degradation processes of thio organophosphates, because more toxic oxo organophosphates might be formed and overlooked by Vibrio fischeri bioluminescence inhibition. In addition, during organophosphates removal by AOP, compounds with strong genotoxic potential may be formed, which cannot be detected by standard toxicity tests. For this reason, determination of incidence of micronuclei and cell proliferation index in cultivated human lymphocytes and fibroblasts is suitable for evaluation of organophosphorus insecticides and their break down products inducing cytogenetic damage.",
journal = "Hemijska industrija",
title = "Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes",
volume = "67",
number = "2",
pages = "217-230",
doi = "10.2298/HEMIND120323060C"
}
Čolović, M. B., Krstić, D. Z., Vasić, V. M., Bondžić, A. M., Uscumlic, G. S.,& Petrovic, S. D.. (2013). Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes. in Hemijska industrija, 67(2), 217-230.
https://doi.org/10.2298/HEMIND120323060C
Čolović MB, Krstić DZ, Vasić VM, Bondžić AM, Uscumlic GS, Petrovic SD. Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes. in Hemijska industrija. 2013;67(2):217-230.
doi:10.2298/HEMIND120323060C .
Čolović, Mirjana B., Krstić, Danijela Z., Vasić, Vesna M., Bondžić, Aleksandra M., Uscumlic, Gordana S., Petrovic, Slobodan D., "Organophosphorus Insecticides: Toxic Effects and Bioanalytical Tests for Evaluating Toxicity During Degradation Processes" in Hemijska industrija, 67, no. 2 (2013):217-230,
https://doi.org/10.2298/HEMIND120323060C . .
5
3
6

Analysis of Factors Influencing Cu(II) Sorption By Clinoptiolite

Šljivić-Ivanović, Marija Z.; Smičiklas, Ivana D.; Marković, Jelena P.; Milenković, Aleksandra S.

(2013)

TY  - JOUR
AU  - Šljivić-Ivanović, Marija Z.
AU  - Smičiklas, Ivana D.
AU  - Marković, Jelena P.
AU  - Milenković, Aleksandra S.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5804
AB  - Experimental design methodology represents a powerful tool for the analysis and optimization of various processes. Immobilization of toxic substances by sorption onto low-cost materials has gained a lot of attention in the last decade. Fundamental knowledge about sorption processes and their practical use can be improved by experimental planning and statistical analysis. In this study, the effects of initial metal concentration and pH, as well as the sorbent mass and particle size, on Cu(II) sorption by natural clinoptilolite were evaluated and compared. Full factorial experimental design at two levels was applied. Statistically significant factors were determined considering residual Cu(II) concentrations as a system response. The Pareto graphs of standardized effects, Main effect plots and Interaction plots were created using statistical software. Initial sorbate concentration, sorbent mass and their interaction were recognized as statistically significant, at 95% confidence level. Main effect plot approved that sorbent mass increase and initial Cu(II) concentration decrease caused reduction of residual Cu(II) concentration in solution. On the other hand, the change of initial solution pH and sorbent particle size didnt provoke significant response changes. Bearing in mind that pH is a factor with high effect on heavy metal sorption, the insignificant influence of initial pH detected in this study can be explained by buffering properties of the applied clinoptilolite and relatively narrow pH range chosen in order to prevent sorbent dissolution on one side and sorbate precipitation on the other. By regression analysis, the mathematical model for process description was derived. The correlation between predicted and experimental values was high (R-2 GT 0.99). In the investigated ranges of parameters, the obtained empirical equation can be applied for the prediction of system response.
T2  - Hemijska industrija
T1  - Analysis of Factors Influencing Cu(II) Sorption By Clinoptiolite
VL  - 67
IS  - 5
SP  - 739
EP  - 745
DO  - 10.2298/HEMIND121123121S
ER  - 
@article{
author = "Šljivić-Ivanović, Marija Z. and Smičiklas, Ivana D. and Marković, Jelena P. and Milenković, Aleksandra S.",
year = "2013",
abstract = "Experimental design methodology represents a powerful tool for the analysis and optimization of various processes. Immobilization of toxic substances by sorption onto low-cost materials has gained a lot of attention in the last decade. Fundamental knowledge about sorption processes and their practical use can be improved by experimental planning and statistical analysis. In this study, the effects of initial metal concentration and pH, as well as the sorbent mass and particle size, on Cu(II) sorption by natural clinoptilolite were evaluated and compared. Full factorial experimental design at two levels was applied. Statistically significant factors were determined considering residual Cu(II) concentrations as a system response. The Pareto graphs of standardized effects, Main effect plots and Interaction plots were created using statistical software. Initial sorbate concentration, sorbent mass and their interaction were recognized as statistically significant, at 95% confidence level. Main effect plot approved that sorbent mass increase and initial Cu(II) concentration decrease caused reduction of residual Cu(II) concentration in solution. On the other hand, the change of initial solution pH and sorbent particle size didnt provoke significant response changes. Bearing in mind that pH is a factor with high effect on heavy metal sorption, the insignificant influence of initial pH detected in this study can be explained by buffering properties of the applied clinoptilolite and relatively narrow pH range chosen in order to prevent sorbent dissolution on one side and sorbate precipitation on the other. By regression analysis, the mathematical model for process description was derived. The correlation between predicted and experimental values was high (R-2 GT 0.99). In the investigated ranges of parameters, the obtained empirical equation can be applied for the prediction of system response.",
journal = "Hemijska industrija",
title = "Analysis of Factors Influencing Cu(II) Sorption By Clinoptiolite",
volume = "67",
number = "5",
pages = "739-745",
doi = "10.2298/HEMIND121123121S"
}
Šljivić-Ivanović, M. Z., Smičiklas, I. D., Marković, J. P.,& Milenković, A. S.. (2013). Analysis of Factors Influencing Cu(II) Sorption By Clinoptiolite. in Hemijska industrija, 67(5), 739-745.
https://doi.org/10.2298/HEMIND121123121S
Šljivić-Ivanović MZ, Smičiklas ID, Marković JP, Milenković AS. Analysis of Factors Influencing Cu(II) Sorption By Clinoptiolite. in Hemijska industrija. 2013;67(5):739-745.
doi:10.2298/HEMIND121123121S .
Šljivić-Ivanović, Marija Z., Smičiklas, Ivana D., Marković, Jelena P., Milenković, Aleksandra S., "Analysis of Factors Influencing Cu(II) Sorption By Clinoptiolite" in Hemijska industrija, 67, no. 5 (2013):739-745,
https://doi.org/10.2298/HEMIND121123121S . .
1
1