TY  - JOUR
AU  - Ghalib, Raza Murad
AU  - Mehdi, Sayed Hasan
AU  - Malla, Ali Mohammed
AU  - Alam, Mohd Gulfam
AU  - Hashim, Rokiali
AU  - Novaković, Slađana B.
AU  - Kawamura, F.
AU  - Alzahrani, Hassan A.H.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10093
AB  - A heterocyclic molecule of a novel class with a multiple ring system has been synthesized using a new and simple strategy and acetic acid as catalyst. The structure of the title molecule has been determined by spectral analysis and single crystal X-ray diffraction analysis. The compound crystallizes in monoclinic system, space group P21/c, with two crystallographically independent molecules in an asymmetric unit. The two molecules show close comparable geometric parameters and a similar conformation of fused-ring systems. The crystal structure is stabilized by a combination of N–H⋅⋅⋅O and C–H⋅⋅⋅O hydrogen bonds, where independent molecules display equivalent interaction patterns.
T2  - Crystallography Reports
T1  - Novel Indole-Pyrazine Alkaloid: Synthesis, Characterization, and Crystal Structure
VL  - 66
IS  - 7
SP  - 1279
EP  - 1285
DO  - 10.1134/S1063774521070051
ER  - 

@article{
author = "Ghalib, Raza Murad and Mehdi, Sayed Hasan and Malla, Ali Mohammed and Alam, Mohd Gulfam and Hashim, Rokiali and Novaković, Slađana B. and Kawamura, F. and Alzahrani, Hassan A.H.",
year = "2021",
abstract = "A heterocyclic molecule of a novel class with a multiple ring system has been synthesized using a new and simple strategy and acetic acid as catalyst. The structure of the title molecule has been determined by spectral analysis and single crystal X-ray diffraction analysis. The compound crystallizes in monoclinic system, space group P21/c, with two crystallographically independent molecules in an asymmetric unit. The two molecules show close comparable geometric parameters and a similar conformation of fused-ring systems. The crystal structure is stabilized by a combination of N–H⋅⋅⋅O and C–H⋅⋅⋅O hydrogen bonds, where independent molecules display equivalent interaction patterns.",
journal = "Crystallography Reports",
title = "Novel Indole-Pyrazine Alkaloid: Synthesis, Characterization, and Crystal Structure",
volume = "66",
number = "7",
pages = "1279-1285",
doi = "10.1134/S1063774521070051"
}

Ghalib, R. M., Mehdi, S. H., Malla, A. M., Alam, M. G., Hashim, R., Novaković, S. B., Kawamura, F.,& Alzahrani, H. A.H.. (2021). Novel Indole-Pyrazine Alkaloid: Synthesis, Characterization, and Crystal Structure. in Crystallography Reports, 66(7), 1279-1285.
https://doi.org/10.1134/S1063774521070051

Ghalib RM, Mehdi SH, Malla AM, Alam MG, Hashim R, Novaković SB, Kawamura F, Alzahrani HA. Novel Indole-Pyrazine Alkaloid: Synthesis, Characterization, and Crystal Structure. in Crystallography Reports. 2021;66(7):1279-1285.
doi:10.1134/S1063774521070051 .

Ghalib, Raza Murad, Mehdi, Sayed Hasan, Malla, Ali Mohammed, Alam, Mohd Gulfam, Hashim, Rokiali, Novaković, Slađana B., Kawamura, F., Alzahrani, Hassan A.H., "Novel Indole-Pyrazine Alkaloid: Synthesis, Characterization, and Crystal Structure" in Crystallography Reports, 66, no. 7 (2021):1279-1285,
https://doi.org/10.1134/S1063774521070051 . .

TY  - JOUR
AU  - Alam, Mohd Gulfam
AU  - Trifunović, Srećko R.
AU  - Bogdanović, Goran A.
AU  - Malla, Ali Mohammed
AU  - Mehdi, Sayed Hasan
AU  - Ghalib, Raza Murad
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9635
AB  - An easy access has been demonstrated for seven membered diazepines and a six membered quinoxaline. The reaction proceeds rapidly with low-cost and readily available chemicals at mild temperature and provides straight forward access to diazepines and quinoxaline. All final products are new and confirmed by spectral analysis and by single crystal X-ray analysis. Two crystal structures of the diazepines have very similar compositions, exhibit similar conformations where four condensed and coplanar rings are placed in the same orientation to the rest of molecule.
T2  - Arabian Journal of Chemistry
T1  - Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines
VL  - 13
IS  - 10
SP  - 7338
EP  - 7345
DO  - 10.1016/j.arabjc.2020.08.011
ER  - 

@article{
author = "Alam, Mohd Gulfam and Trifunović, Srećko R. and Bogdanović, Goran A. and Malla, Ali Mohammed and Mehdi, Sayed Hasan and Ghalib, Raza Murad",
year = "2020",
abstract = "An easy access has been demonstrated for seven membered diazepines and a six membered quinoxaline. The reaction proceeds rapidly with low-cost and readily available chemicals at mild temperature and provides straight forward access to diazepines and quinoxaline. All final products are new and confirmed by spectral analysis and by single crystal X-ray analysis. Two crystal structures of the diazepines have very similar compositions, exhibit similar conformations where four condensed and coplanar rings are placed in the same orientation to the rest of molecule.",
journal = "Arabian Journal of Chemistry",
title = "Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines",
volume = "13",
number = "10",
pages = "7338-7345",
doi = "10.1016/j.arabjc.2020.08.011"
}

Alam, M. G., Trifunović, S. R., Bogdanović, G. A., Malla, A. M., Mehdi, S. H.,& Ghalib, R. M.. (2020). Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines. in Arabian Journal of Chemistry, 13(10), 7338-7345.
https://doi.org/10.1016/j.arabjc.2020.08.011

Alam MG, Trifunović SR, Bogdanović GA, Malla AM, Mehdi SH, Ghalib RM. Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines. in Arabian Journal of Chemistry. 2020;13(10):7338-7345.
doi:10.1016/j.arabjc.2020.08.011 .

Alam, Mohd Gulfam, Trifunović, Srećko R., Bogdanović, Goran A., Malla, Ali Mohammed, Mehdi, Sayed Hasan, Ghalib, Raza Murad, "Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines" in Arabian Journal of Chemistry, 13, no. 10 (2020):7338-7345,
https://doi.org/10.1016/j.arabjc.2020.08.011 . .

TY  - JOUR
AU  - Ghalib, Raza Murad
AU  - Hashim, Rokiah
AU  - Sulaiman, Othman
AU  - Jawad, Ali
AU  - Mehdi, Sayed Hasan
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Kawamura, Fumio
AU  - Ahamed, B. M. Khadeer
AU  - Majid, Amin Malik Shah Abdul
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1431
AB  - Background: Heterocyclic molecules have been synthesized by a green and facile strategy. These mole-cules contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single crystal X-ray analysis. These compounds have anticancer activity. Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1: 1 were heated on water bath for 15 minutes. The reaction mixtures were dried on rotary evaporator and crystallized with chloro-form- n-hexane (1: 1 v/v) to give the colorless crystals of 1 And 2 respectively. Compounds 3 and 4 were synthe-sized by adding o-phenylenediamine to the completed reaction mixtures of 1 and 2 and each was further heated on water bath for 5 minutes. The dried reaction mixtures were chromatographed over a silica gel column and crystalized as 3 and 4. Results: This strategy resulted novel class of anticancer benzazocines (3 and 4). Conclusion: This method features mild reaction conditions and simple operation. The synthesis completes in two steps; from ninhydrin to 1 and 2 and from 1 and 2 to 3 and 4. The same basic skeleton of 3 and 4 and the same synthesis procedure clearly shows the general applicability of this reaction that is also proved enough by single crystal X-ray analysis and the strategy can be applicable for a wide range of other substrates. The obtained compounds are potential anticancer agents.
T2  - Current Organic Synthesis
T1  - Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity
VL  - 14
IS  - 1
SP  - 127
EP  - 136
DO  - 10.2174/1570179413666151218201848
ER  - 

@article{
author = "Ghalib, Raza Murad and Hashim, Rokiah and Sulaiman, Othman and Jawad, Ali and Mehdi, Sayed Hasan and Bogdanović, Goran A. and Trifunović, Srećko R. and Kawamura, Fumio and Ahamed, B. M. Khadeer and Majid, Amin Malik Shah Abdul",
year = "2017",
abstract = "Background: Heterocyclic molecules have been synthesized by a green and facile strategy. These mole-cules contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single crystal X-ray analysis. These compounds have anticancer activity. Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1: 1 were heated on water bath for 15 minutes. The reaction mixtures were dried on rotary evaporator and crystallized with chloro-form- n-hexane (1: 1 v/v) to give the colorless crystals of 1 And 2 respectively. Compounds 3 and 4 were synthe-sized by adding o-phenylenediamine to the completed reaction mixtures of 1 and 2 and each was further heated on water bath for 5 minutes. The dried reaction mixtures were chromatographed over a silica gel column and crystalized as 3 and 4. Results: This strategy resulted novel class of anticancer benzazocines (3 and 4). Conclusion: This method features mild reaction conditions and simple operation. The synthesis completes in two steps; from ninhydrin to 1 and 2 and from 1 and 2 to 3 and 4. The same basic skeleton of 3 and 4 and the same synthesis procedure clearly shows the general applicability of this reaction that is also proved enough by single crystal X-ray analysis and the strategy can be applicable for a wide range of other substrates. The obtained compounds are potential anticancer agents.",
journal = "Current Organic Synthesis",
title = "Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity",
volume = "14",
number = "1",
pages = "127-136",
doi = "10.2174/1570179413666151218201848"
}

Ghalib, R. M., Hashim, R., Sulaiman, O., Jawad, A., Mehdi, S. H., Bogdanović, G. A., Trifunović, S. R., Kawamura, F., Ahamed, B. M. K.,& Majid, A. M. S. A.. (2017). Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity. in Current Organic Synthesis, 14(1), 127-136.
https://doi.org/10.2174/1570179413666151218201848

Ghalib RM, Hashim R, Sulaiman O, Jawad A, Mehdi SH, Bogdanović GA, Trifunović SR, Kawamura F, Ahamed BMK, Majid AMSA. Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity. in Current Organic Synthesis. 2017;14(1):127-136.
doi:10.2174/1570179413666151218201848 .

Ghalib, Raza Murad, Hashim, Rokiah, Sulaiman, Othman, Jawad, Ali, Mehdi, Sayed Hasan, Bogdanović, Goran A., Trifunović, Srećko R., Kawamura, Fumio, Ahamed, B. M. Khadeer, Majid, Amin Malik Shah Abdul, "Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity" in Current Organic Synthesis, 14, no. 1 (2017):127-136,
https://doi.org/10.2174/1570179413666151218201848 . .