TY  - JOUR
AU  - Petrović, Marija
AU  - Popović, Suzana
AU  - Baskić, Dejan
AU  - Todorović, Miloš
AU  - Đurđević, Predrag
AU  - Ristić-Fira, Aleksandra
AU  - Keta, Otilija D.
AU  - Petković, Vladana
AU  - Korićanac, Lela
AU  - Stojković, Danijela
AU  - Jevtić, Verica
AU  - Trifunović, Srećko
AU  - Todorović, Danijela
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9631
AB  - Aim: Newly synthesized platinum(IV) complexes with ethylenediamine-N,N’-diacetate ligands (EDDA-type) (butyl-Pt and pentyl-Pt) were investigated against two cancer (A549 lung, and HTB 140 melanoma) and one non-cancerous (MRC-5 embryonic lung fibroblast) human cell lines. Materials and Methods: The effects of these agents were compared with those of cisplatin after 6-, 24- and 48-h treatment. Sulforhodamine-B (SRB) assay was performed to estimate the cytotoxic effect, while the inhibitory effect on cell proliferation was measured using 5-bromo-2,-deoxyuridine (BrdU) incorporation assay. Cell cycle analysis was performed by flow cytometry. Type of cell death induced by these agents was determined by electrophoretic analysis of DNA, flow cytometry and by western blot analysis of proteins involved in induction of apoptosis. The effects of gamma irradiation, alone and in combination with platinum-based compounds, were examined by clonogenic and SRB assays. Results: All examined platinum-based compounds had inhibitory and antiproliferative effects on A549 cells, but not on HTB140 and MRC-5 cells. Butyl-Pt, pentyl-Pt and cisplatin arrested the cell cycle in the S-phase and induced apoptotic cell death via regulation of expression of B-cell lymphoma 2 (BCL2) and BCL2-associated X (BAX) proteins. Platinum-based compounds increased the sensitivity of A549 cells to gamma irradiation. Butyl-Pt and pentyl-Pt showed better antitumour effects against A549 cells than did cisplatin, by interfering in cell proliferation and the cell cycle, and by triggering apoptosis. Conclusion: The effects of gamma irradiation on tumour cells may be amplified by pre-treatment of cells with platinum-based compounds.
T2  - Anticancer Research
T1  - The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro
VL  - 40
IS  - 9
SP  - 5001
EP  - 5013
DO  - 10.21873/anticanres.14503
ER  - 

@article{
author = "Petrović, Marija and Popović, Suzana and Baskić, Dejan and Todorović, Miloš and Đurđević, Predrag and Ristić-Fira, Aleksandra and Keta, Otilija D. and Petković, Vladana and Korićanac, Lela and Stojković, Danijela and Jevtić, Verica and Trifunović, Srećko and Todorović, Danijela",
year = "2020",
abstract = "Aim: Newly synthesized platinum(IV) complexes with ethylenediamine-N,N’-diacetate ligands (EDDA-type) (butyl-Pt and pentyl-Pt) were investigated against two cancer (A549 lung, and HTB 140 melanoma) and one non-cancerous (MRC-5 embryonic lung fibroblast) human cell lines. Materials and Methods: The effects of these agents were compared with those of cisplatin after 6-, 24- and 48-h treatment. Sulforhodamine-B (SRB) assay was performed to estimate the cytotoxic effect, while the inhibitory effect on cell proliferation was measured using 5-bromo-2,-deoxyuridine (BrdU) incorporation assay. Cell cycle analysis was performed by flow cytometry. Type of cell death induced by these agents was determined by electrophoretic analysis of DNA, flow cytometry and by western blot analysis of proteins involved in induction of apoptosis. The effects of gamma irradiation, alone and in combination with platinum-based compounds, were examined by clonogenic and SRB assays. Results: All examined platinum-based compounds had inhibitory and antiproliferative effects on A549 cells, but not on HTB140 and MRC-5 cells. Butyl-Pt, pentyl-Pt and cisplatin arrested the cell cycle in the S-phase and induced apoptotic cell death via regulation of expression of B-cell lymphoma 2 (BCL2) and BCL2-associated X (BAX) proteins. Platinum-based compounds increased the sensitivity of A549 cells to gamma irradiation. Butyl-Pt and pentyl-Pt showed better antitumour effects against A549 cells than did cisplatin, by interfering in cell proliferation and the cell cycle, and by triggering apoptosis. Conclusion: The effects of gamma irradiation on tumour cells may be amplified by pre-treatment of cells with platinum-based compounds.",
journal = "Anticancer Research",
title = "The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro",
volume = "40",
number = "9",
pages = "5001-5013",
doi = "10.21873/anticanres.14503"
}

Petrović, M., Popović, S., Baskić, D., Todorović, M., Đurđević, P., Ristić-Fira, A., Keta, O. D., Petković, V., Korićanac, L., Stojković, D., Jevtić, V., Trifunović, S.,& Todorović, D.. (2020). The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro. in Anticancer Research, 40(9), 5001-5013.
https://doi.org/10.21873/anticanres.14503

Petrović M, Popović S, Baskić D, Todorović M, Đurđević P, Ristić-Fira A, Keta OD, Petković V, Korićanac L, Stojković D, Jevtić V, Trifunović S, Todorović D. The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro. in Anticancer Research. 2020;40(9):5001-5013.
doi:10.21873/anticanres.14503 .

Petrović, Marija, Popović, Suzana, Baskić, Dejan, Todorović, Miloš, Đurđević, Predrag, Ristić-Fira, Aleksandra, Keta, Otilija D., Petković, Vladana, Korićanac, Lela, Stojković, Danijela, Jevtić, Verica, Trifunović, Srećko, Todorović, Danijela, "The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro" in Anticancer Research, 40, no. 9 (2020):5001-5013,
https://doi.org/10.21873/anticanres.14503 . .

TY  - JOUR
AU  - Alam, Mohd Gulfam
AU  - Trifunović, Srećko R.
AU  - Bogdanović, Goran A.
AU  - Malla, Ali Mohammed
AU  - Mehdi, Sayed Hasan
AU  - Ghalib, Raza Murad
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9635
AB  - An easy access has been demonstrated for seven membered diazepines and a six membered quinoxaline. The reaction proceeds rapidly with low-cost and readily available chemicals at mild temperature and provides straight forward access to diazepines and quinoxaline. All final products are new and confirmed by spectral analysis and by single crystal X-ray analysis. Two crystal structures of the diazepines have very similar compositions, exhibit similar conformations where four condensed and coplanar rings are placed in the same orientation to the rest of molecule.
T2  - Arabian Journal of Chemistry
T1  - Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines
VL  - 13
IS  - 10
SP  - 7338
EP  - 7345
DO  - 10.1016/j.arabjc.2020.08.011
ER  - 

@article{
author = "Alam, Mohd Gulfam and Trifunović, Srećko R. and Bogdanović, Goran A. and Malla, Ali Mohammed and Mehdi, Sayed Hasan and Ghalib, Raza Murad",
year = "2020",
abstract = "An easy access has been demonstrated for seven membered diazepines and a six membered quinoxaline. The reaction proceeds rapidly with low-cost and readily available chemicals at mild temperature and provides straight forward access to diazepines and quinoxaline. All final products are new and confirmed by spectral analysis and by single crystal X-ray analysis. Two crystal structures of the diazepines have very similar compositions, exhibit similar conformations where four condensed and coplanar rings are placed in the same orientation to the rest of molecule.",
journal = "Arabian Journal of Chemistry",
title = "Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines",
volume = "13",
number = "10",
pages = "7338-7345",
doi = "10.1016/j.arabjc.2020.08.011"
}

Alam, M. G., Trifunović, S. R., Bogdanović, G. A., Malla, A. M., Mehdi, S. H.,& Ghalib, R. M.. (2020). Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines. in Arabian Journal of Chemistry, 13(10), 7338-7345.
https://doi.org/10.1016/j.arabjc.2020.08.011

Alam MG, Trifunović SR, Bogdanović GA, Malla AM, Mehdi SH, Ghalib RM. Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines. in Arabian Journal of Chemistry. 2020;13(10):7338-7345.
doi:10.1016/j.arabjc.2020.08.011 .

Alam, Mohd Gulfam, Trifunović, Srećko R., Bogdanović, Goran A., Malla, Ali Mohammed, Mehdi, Sayed Hasan, Ghalib, Raza Murad, "Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines" in Arabian Journal of Chemistry, 13, no. 10 (2020):7338-7345,
https://doi.org/10.1016/j.arabjc.2020.08.011 . .

TY  - JOUR
AU  - Jovanović, Snežana
AU  - Bogojeski, Jovana V.
AU  - Nikolić, Miloš V.
AU  - Mijajlović, Marina Ž.
AU  - Tomović, Dušan Lj.
AU  - Bukonjić, Andriana M.
AU  - Knežević Rangelov, Sanja M.
AU  - Mijailović, Nataša R.
AU  - Ratković, Zoran R.
AU  - Jevtić, Verica V.
AU  - Petrović, Biljana V.
AU  - Trifunović, Srećko R.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Radić, Gordana P.
PY  - 2019
UR  - https://www.tandfonline.com/doi/full/10.1080/00958972.2019.1610561
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8196
AB  - Interactions of copper(II) complexes which contain S-alkyl derivatives of thiosalicylic acid (alkyl = methyl, ethyl, propyl and butyl; aryl = benzyl), marked as 1–5, with guanosine-5′-monophosphate (5′-GMP) and calf thymus DNA (CT-DNA) were studied. Kinetics of substitution reactions of 1–5 with 5′-GMP and CT-DNA were investigated under pseudo-first-order conditions at 310 K and pH = 7.2 in 25 mM Hepes buffer using stopped-flow method. All complexes have high affinity toward studied bio-molecules. Additionally, interactions with CT-DNA were followed by absorption spectroscopy and fluorescence quenching measurements. The results indicate that complexes bind to DNA exhibiting high binding constants (Kb = 104 M−1). During the examination of competitive reactions with ethidium bromide (EB), results showed that complexes can replace EB-bound DNA. In addition, a new crystal structure of the binuclear Cu(II) complex with S-substituted thiosalicylate derivative has been reported. In the present series of Cu(II) complexes the crystal structure is the first example of a complex comprising an S-aryl derivative of thiosalicylate ligand. Through comparative study of structural properties of six molecules from four crystal structures we examined the structural variations, potentially important for biological activity of these complexes. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
T2  - Journal of Coordination Chemistry
T1  - Interactions of binuclear copper(II) complexes with S-substituted thiosalicylate derivatives with some relevant biomolecules
VL  - 72
IS  - 10
SP  - 1603
EP  - 1620
DO  - 10.1080/00958972.2019.1610561
ER  - 

@article{
author = "Jovanović, Snežana and Bogojeski, Jovana V. and Nikolić, Miloš V. and Mijajlović, Marina Ž. and Tomović, Dušan Lj. and Bukonjić, Andriana M. and Knežević Rangelov, Sanja M. and Mijailović, Nataša R. and Ratković, Zoran R. and Jevtić, Verica V. and Petrović, Biljana V. and Trifunović, Srećko R. and Novaković, Slađana B. and Bogdanović, Goran A. and Radić, Gordana P.",
year = "2019",
abstract = "Interactions of copper(II) complexes which contain S-alkyl derivatives of thiosalicylic acid (alkyl = methyl, ethyl, propyl and butyl; aryl = benzyl), marked as 1–5, with guanosine-5′-monophosphate (5′-GMP) and calf thymus DNA (CT-DNA) were studied. Kinetics of substitution reactions of 1–5 with 5′-GMP and CT-DNA were investigated under pseudo-first-order conditions at 310 K and pH = 7.2 in 25 mM Hepes buffer using stopped-flow method. All complexes have high affinity toward studied bio-molecules. Additionally, interactions with CT-DNA were followed by absorption spectroscopy and fluorescence quenching measurements. The results indicate that complexes bind to DNA exhibiting high binding constants (Kb = 104 M−1). During the examination of competitive reactions with ethidium bromide (EB), results showed that complexes can replace EB-bound DNA. In addition, a new crystal structure of the binuclear Cu(II) complex with S-substituted thiosalicylate derivative has been reported. In the present series of Cu(II) complexes the crystal structure is the first example of a complex comprising an S-aryl derivative of thiosalicylate ligand. Through comparative study of structural properties of six molecules from four crystal structures we examined the structural variations, potentially important for biological activity of these complexes. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.",
journal = "Journal of Coordination Chemistry",
title = "Interactions of binuclear copper(II) complexes with S-substituted thiosalicylate derivatives with some relevant biomolecules",
volume = "72",
number = "10",
pages = "1603-1620",
doi = "10.1080/00958972.2019.1610561"
}

Jovanović, S., Bogojeski, J. V., Nikolić, M. V., Mijajlović, M. Ž., Tomović, D. Lj., Bukonjić, A. M., Knežević Rangelov, S. M., Mijailović, N. R., Ratković, Z. R., Jevtić, V. V., Petrović, B. V., Trifunović, S. R., Novaković, S. B., Bogdanović, G. A.,& Radić, G. P.. (2019). Interactions of binuclear copper(II) complexes with S-substituted thiosalicylate derivatives with some relevant biomolecules. in Journal of Coordination Chemistry, 72(10), 1603-1620.
https://doi.org/10.1080/00958972.2019.1610561

Jovanović S, Bogojeski JV, Nikolić MV, Mijajlović MŽ, Tomović DL, Bukonjić AM, Knežević Rangelov SM, Mijailović NR, Ratković ZR, Jevtić VV, Petrović BV, Trifunović SR, Novaković SB, Bogdanović GA, Radić GP. Interactions of binuclear copper(II) complexes with S-substituted thiosalicylate derivatives with some relevant biomolecules. in Journal of Coordination Chemistry. 2019;72(10):1603-1620.
doi:10.1080/00958972.2019.1610561 .

Jovanović, Snežana, Bogojeski, Jovana V., Nikolić, Miloš V., Mijajlović, Marina Ž., Tomović, Dušan Lj., Bukonjić, Andriana M., Knežević Rangelov, Sanja M., Mijailović, Nataša R., Ratković, Zoran R., Jevtić, Verica V., Petrović, Biljana V., Trifunović, Srećko R., Novaković, Slađana B., Bogdanović, Goran A., Radić, Gordana P., "Interactions of binuclear copper(II) complexes with S-substituted thiosalicylate derivatives with some relevant biomolecules" in Journal of Coordination Chemistry, 72, no. 10 (2019):1603-1620,
https://doi.org/10.1080/00958972.2019.1610561 . .

TY  - JOUR
AU  - Tomović, Dušan Lj.
AU  - Bukonjić, Andriana M.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Bogojeski, Jovana V.
AU  - Đeković, Ana
AU  - Radojevic, Ivana D.
AU  - Čomić, Ljiljana R.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
AU  - Cupara, Snežana
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1954
AB  - The biological activities of two binuclear copper(II) complexes containing S-alkenyl derivatives of thiosalicylic acid are reported [alkenyl = propenyl (L1), isobutenyl (L2)]. The structure of the complex with the S-isobutenyl derivative (C2) was confirmed by single-crystal X-ray structure analysis, which revealed that the structure consists of centrosymmetric, dinuclear complex molecules [Cu-2(S-i-butenyl-thiosal)(4)(DMSO)(2)] containing two Cu(II) centers bridged by four S-isobutyl-thiosalicylate ligands in a paddle-wheel type structure. The Cu(II) atom is situated in a distorted square-pyramidal environment formed by carboxylate oxygen atoms in the basal plane and a DMSO ligand in the axial position. The reactivities of the complexes toward guanosine-5-monophosphate (5-GMP) were investigated. Complex C2 ([Cu-2(S-i-butenyl-thiosal)(4)(H2O)(2)]) reacted more rapidly with 5-GMP than complex C1. The interactions of complexes C1 and C2 with calf thymus DNA (CT-DNA) were examined by absorption (UV-Vis) and emission spectral studies (ethidium bromide displacement studies), revealing good DNA interaction abilities. The antimicrobial activities of the free ligands and their complexes were tested by microdilution method, and both minimal inhibitory and microbicidal concentrations were determined. All the tested substances demonstrated selective and moderate antibacterial activity on gram-positive bacteria, but low antibacterial activity on gram-negative bacteria. Also, the tested substances demonstrated low antifungal activity.
T2  - Transition Metal Chemistry
T1  - DNA binding, antibacterial and antifungal activities of copper(II) complexes with some S-alkenyl derivatives of thiosalicylic acid
VL  - 43
IS  - 2
SP  - 137
EP  - 148
DO  - 10.1007/s11243-018-0201-0
ER  - 

@article{
author = "Tomović, Dušan Lj. and Bukonjić, Andriana M. and Jevtić, Verica V. and Ratković, Zoran R. and Bogojeski, Jovana V. and Đeković, Ana and Radojevic, Ivana D. and Čomić, Ljiljana R. and Novaković, Slađana B. and Bogdanović, Goran A. and Trifunović, Srećko R. and Radić, Gordana P. and Cupara, Snežana",
year = "2018",
abstract = "The biological activities of two binuclear copper(II) complexes containing S-alkenyl derivatives of thiosalicylic acid are reported [alkenyl = propenyl (L1), isobutenyl (L2)]. The structure of the complex with the S-isobutenyl derivative (C2) was confirmed by single-crystal X-ray structure analysis, which revealed that the structure consists of centrosymmetric, dinuclear complex molecules [Cu-2(S-i-butenyl-thiosal)(4)(DMSO)(2)] containing two Cu(II) centers bridged by four S-isobutyl-thiosalicylate ligands in a paddle-wheel type structure. The Cu(II) atom is situated in a distorted square-pyramidal environment formed by carboxylate oxygen atoms in the basal plane and a DMSO ligand in the axial position. The reactivities of the complexes toward guanosine-5-monophosphate (5-GMP) were investigated. Complex C2 ([Cu-2(S-i-butenyl-thiosal)(4)(H2O)(2)]) reacted more rapidly with 5-GMP than complex C1. The interactions of complexes C1 and C2 with calf thymus DNA (CT-DNA) were examined by absorption (UV-Vis) and emission spectral studies (ethidium bromide displacement studies), revealing good DNA interaction abilities. The antimicrobial activities of the free ligands and their complexes were tested by microdilution method, and both minimal inhibitory and microbicidal concentrations were determined. All the tested substances demonstrated selective and moderate antibacterial activity on gram-positive bacteria, but low antibacterial activity on gram-negative bacteria. Also, the tested substances demonstrated low antifungal activity.",
journal = "Transition Metal Chemistry",
title = "DNA binding, antibacterial and antifungal activities of copper(II) complexes with some S-alkenyl derivatives of thiosalicylic acid",
volume = "43",
number = "2",
pages = "137-148",
doi = "10.1007/s11243-018-0201-0"
}

Tomović, D. Lj., Bukonjić, A. M., Jevtić, V. V., Ratković, Z. R., Bogojeski, J. V., Đeković, A., Radojevic, I. D., Čomić, L. R., Novaković, S. B., Bogdanović, G. A., Trifunović, S. R., Radić, G. P.,& Cupara, S.. (2018). DNA binding, antibacterial and antifungal activities of copper(II) complexes with some S-alkenyl derivatives of thiosalicylic acid. in Transition Metal Chemistry, 43(2), 137-148.
https://doi.org/10.1007/s11243-018-0201-0

Tomović DL, Bukonjić AM, Jevtić VV, Ratković ZR, Bogojeski JV, Đeković A, Radojevic ID, Čomić LR, Novaković SB, Bogdanović GA, Trifunović SR, Radić GP, Cupara S. DNA binding, antibacterial and antifungal activities of copper(II) complexes with some S-alkenyl derivatives of thiosalicylic acid. in Transition Metal Chemistry. 2018;43(2):137-148.
doi:10.1007/s11243-018-0201-0 .

Tomović, Dušan Lj., Bukonjić, Andriana M., Jevtić, Verica V., Ratković, Zoran R., Bogojeski, Jovana V., Đeković, Ana, Radojevic, Ivana D., Čomić, Ljiljana R., Novaković, Slađana B., Bogdanović, Goran A., Trifunović, Srećko R., Radić, Gordana P., Cupara, Snežana, "DNA binding, antibacterial and antifungal activities of copper(II) complexes with some S-alkenyl derivatives of thiosalicylic acid" in Transition Metal Chemistry, 43, no. 2 (2018):137-148,
https://doi.org/10.1007/s11243-018-0201-0 . .

TY  - JOUR
AU  - Ghalib, Raza Murad
AU  - Hashim, Rokiah
AU  - Sulaiman, Othman
AU  - Jawad, Ali
AU  - Mehdi, Sayed Hasan
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Kawamura, Fumio
AU  - Ahamed, B. M. Khadeer
AU  - Majid, Amin Malik Shah Abdul
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1431
AB  - Background: Heterocyclic molecules have been synthesized by a green and facile strategy. These mole-cules contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single crystal X-ray analysis. These compounds have anticancer activity. Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1: 1 were heated on water bath for 15 minutes. The reaction mixtures were dried on rotary evaporator and crystallized with chloro-form- n-hexane (1: 1 v/v) to give the colorless crystals of 1 And 2 respectively. Compounds 3 and 4 were synthe-sized by adding o-phenylenediamine to the completed reaction mixtures of 1 and 2 and each was further heated on water bath for 5 minutes. The dried reaction mixtures were chromatographed over a silica gel column and crystalized as 3 and 4. Results: This strategy resulted novel class of anticancer benzazocines (3 and 4). Conclusion: This method features mild reaction conditions and simple operation. The synthesis completes in two steps; from ninhydrin to 1 and 2 and from 1 and 2 to 3 and 4. The same basic skeleton of 3 and 4 and the same synthesis procedure clearly shows the general applicability of this reaction that is also proved enough by single crystal X-ray analysis and the strategy can be applicable for a wide range of other substrates. The obtained compounds are potential anticancer agents.
T2  - Current Organic Synthesis
T1  - Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity
VL  - 14
IS  - 1
SP  - 127
EP  - 136
DO  - 10.2174/1570179413666151218201848
ER  - 

@article{
author = "Ghalib, Raza Murad and Hashim, Rokiah and Sulaiman, Othman and Jawad, Ali and Mehdi, Sayed Hasan and Bogdanović, Goran A. and Trifunović, Srećko R. and Kawamura, Fumio and Ahamed, B. M. Khadeer and Majid, Amin Malik Shah Abdul",
year = "2017",
abstract = "Background: Heterocyclic molecules have been synthesized by a green and facile strategy. These mole-cules contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single crystal X-ray analysis. These compounds have anticancer activity. Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1: 1 were heated on water bath for 15 minutes. The reaction mixtures were dried on rotary evaporator and crystallized with chloro-form- n-hexane (1: 1 v/v) to give the colorless crystals of 1 And 2 respectively. Compounds 3 and 4 were synthe-sized by adding o-phenylenediamine to the completed reaction mixtures of 1 and 2 and each was further heated on water bath for 5 minutes. The dried reaction mixtures were chromatographed over a silica gel column and crystalized as 3 and 4. Results: This strategy resulted novel class of anticancer benzazocines (3 and 4). Conclusion: This method features mild reaction conditions and simple operation. The synthesis completes in two steps; from ninhydrin to 1 and 2 and from 1 and 2 to 3 and 4. The same basic skeleton of 3 and 4 and the same synthesis procedure clearly shows the general applicability of this reaction that is also proved enough by single crystal X-ray analysis and the strategy can be applicable for a wide range of other substrates. The obtained compounds are potential anticancer agents.",
journal = "Current Organic Synthesis",
title = "Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity",
volume = "14",
number = "1",
pages = "127-136",
doi = "10.2174/1570179413666151218201848"
}

Ghalib, R. M., Hashim, R., Sulaiman, O., Jawad, A., Mehdi, S. H., Bogdanović, G. A., Trifunović, S. R., Kawamura, F., Ahamed, B. M. K.,& Majid, A. M. S. A.. (2017). Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity. in Current Organic Synthesis, 14(1), 127-136.
https://doi.org/10.2174/1570179413666151218201848

Ghalib RM, Hashim R, Sulaiman O, Jawad A, Mehdi SH, Bogdanović GA, Trifunović SR, Kawamura F, Ahamed BMK, Majid AMSA. Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity. in Current Organic Synthesis. 2017;14(1):127-136.
doi:10.2174/1570179413666151218201848 .

Ghalib, Raza Murad, Hashim, Rokiah, Sulaiman, Othman, Jawad, Ali, Mehdi, Sayed Hasan, Bogdanović, Goran A., Trifunović, Srećko R., Kawamura, Fumio, Ahamed, B. M. Khadeer, Majid, Amin Malik Shah Abdul, "Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity" in Current Organic Synthesis, 14, no. 1 (2017):127-136,
https://doi.org/10.2174/1570179413666151218201848 . .

TY  - JOUR
AU  - Bukonjić, Andriana M.
AU  - Tomović, Dušan Lj.
AU  - Nikolić, Miloš V.
AU  - Mijajlović, Marina Ž.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Radojevic, Ivana D.
AU  - Maksimović, Jovana Z.
AU  - Vasić, Sava M.
AU  - Čomić, Ljiljana R.
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1296
AB  - The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of thiosalicylic acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of thiosalicylic acid, [Cu-2(S-et-thiosal)(4)(H2O)(2)] (C3) and copper(II)-complex with S-butyl derivative of thiosalicylic acid, [Cu-2(S-bu-thiosal)(4)(H2O)(2)] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa. ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay). (C) 2016 Elsevier B.V. All rights reserved.
T2  - Journal of Molecular Structure
T1  - Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid
VL  - 1128
SP  - 330
EP  - 337
DO  - 10.1016/j.molstruc.2016.08.086
ER  - 

@article{
author = "Bukonjić, Andriana M. and Tomović, Dušan Lj. and Nikolić, Miloš V. and Mijajlović, Marina Ž. and Jevtić, Verica V. and Ratković, Zoran R. and Novaković, Slađana B. and Bogdanović, Goran A. and Radojevic, Ivana D. and Maksimović, Jovana Z. and Vasić, Sava M. and Čomić, Ljiljana R. and Trifunović, Srećko R. and Radić, Gordana P.",
year = "2017",
abstract = "The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of thiosalicylic acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of thiosalicylic acid, [Cu-2(S-et-thiosal)(4)(H2O)(2)] (C3) and copper(II)-complex with S-butyl derivative of thiosalicylic acid, [Cu-2(S-bu-thiosal)(4)(H2O)(2)] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa. ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay). (C) 2016 Elsevier B.V. All rights reserved.",
journal = "Journal of Molecular Structure",
title = "Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid",
volume = "1128",
pages = "330-337",
doi = "10.1016/j.molstruc.2016.08.086"
}

Bukonjić, A. M., Tomović, D. Lj., Nikolić, M. V., Mijajlović, M. Ž., Jevtić, V. V., Ratković, Z. R., Novaković, S. B., Bogdanović, G. A., Radojevic, I. D., Maksimović, J. Z., Vasić, S. M., Čomić, L. R., Trifunović, S. R.,& Radić, G. P.. (2017). Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid. in Journal of Molecular Structure, 1128, 330-337.
https://doi.org/10.1016/j.molstruc.2016.08.086

Bukonjić AM, Tomović DL, Nikolić MV, Mijajlović MŽ, Jevtić VV, Ratković ZR, Novaković SB, Bogdanović GA, Radojevic ID, Maksimović JZ, Vasić SM, Čomić LR, Trifunović SR, Radić GP. Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid. in Journal of Molecular Structure. 2017;1128:330-337.
doi:10.1016/j.molstruc.2016.08.086 .

Bukonjić, Andriana M., Tomović, Dušan Lj., Nikolić, Miloš V., Mijajlović, Marina Ž., Jevtić, Verica V., Ratković, Zoran R., Novaković, Slađana B., Bogdanović, Goran A., Radojevic, Ivana D., Maksimović, Jovana Z., Vasić, Sava M., Čomić, Ljiljana R., Trifunović, Srećko R., Radić, Gordana P., "Antibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid" in Journal of Molecular Structure, 1128 (2017):330-337,
https://doi.org/10.1016/j.molstruc.2016.08.086 . .

TY  - JOUR
AU  - Mijajlović, Marina Ž.
AU  - Nikolić, Miloš V.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Milovanović, Jelena
AU  - Arsenijević, Aleksandar
AU  - Stojanović, Bojana
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1166
AB  - The syntheses of tetradentate ligand, meso-1,2-diphenyl-ethylenediamine-N,N-di-3-propanoic acid (H-2-1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and Bl6F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cisplatin, the exception was concentrations above 62.5 mu M of platinum(IV) complex in the B16F1 cell line.
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - Cytotoxicity of Platinum(Iv) and Palladium(Ii) Complexes with Meso-1,2-Diphenyl-Ethylenediamine-N,N -Di-3-Propanoic Acid. Crystal Structure of [Pd(1,2-Dpheddp)] Complex
VL  - 35
IS  - 1
SP  - 79
EP  - 86
DO  - 10.20450/mjcce.2016.729
ER  - 

@article{
author = "Mijajlović, Marina Ž. and Nikolić, Miloš V. and Jevtić, Verica V. and Ratković, Zoran R. and Milovanović, Jelena and Arsenijević, Aleksandar and Stojanović, Bojana and Novaković, Slađana B. and Bogdanović, Goran A. and Trifunović, Srećko R. and Radić, Gordana P.",
year = "2016",
abstract = "The syntheses of tetradentate ligand, meso-1,2-diphenyl-ethylenediamine-N,N-di-3-propanoic acid (H-2-1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and Bl6F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cisplatin, the exception was concentrations above 62.5 mu M of platinum(IV) complex in the B16F1 cell line.",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "Cytotoxicity of Platinum(Iv) and Palladium(Ii) Complexes with Meso-1,2-Diphenyl-Ethylenediamine-N,N -Di-3-Propanoic Acid. Crystal Structure of [Pd(1,2-Dpheddp)] Complex",
volume = "35",
number = "1",
pages = "79-86",
doi = "10.20450/mjcce.2016.729"
}

Mijajlović, M. Ž., Nikolić, M. V., Jevtić, V. V., Ratković, Z. R., Milovanović, J., Arsenijević, A., Stojanović, B., Novaković, S. B., Bogdanović, G. A., Trifunović, S. R.,& Radić, G. P.. (2016). Cytotoxicity of Platinum(Iv) and Palladium(Ii) Complexes with Meso-1,2-Diphenyl-Ethylenediamine-N,N -Di-3-Propanoic Acid. Crystal Structure of [Pd(1,2-Dpheddp)] Complex. in Macedonian Journal of Chemistry and Chemical Engineering, 35(1), 79-86.
https://doi.org/10.20450/mjcce.2016.729

Mijajlović MŽ, Nikolić MV, Jevtić VV, Ratković ZR, Milovanović J, Arsenijević A, Stojanović B, Novaković SB, Bogdanović GA, Trifunović SR, Radić GP. Cytotoxicity of Platinum(Iv) and Palladium(Ii) Complexes with Meso-1,2-Diphenyl-Ethylenediamine-N,N -Di-3-Propanoic Acid. Crystal Structure of [Pd(1,2-Dpheddp)] Complex. in Macedonian Journal of Chemistry and Chemical Engineering. 2016;35(1):79-86.
doi:10.20450/mjcce.2016.729 .

Mijajlović, Marina Ž., Nikolić, Miloš V., Jevtić, Verica V., Ratković, Zoran R., Milovanović, Jelena, Arsenijević, Aleksandar, Stojanović, Bojana, Novaković, Slađana B., Bogdanović, Goran A., Trifunović, Srećko R., Radić, Gordana P., "Cytotoxicity of Platinum(Iv) and Palladium(Ii) Complexes with Meso-1,2-Diphenyl-Ethylenediamine-N,N -Di-3-Propanoic Acid. Crystal Structure of [Pd(1,2-Dpheddp)] Complex" in Macedonian Journal of Chemistry and Chemical Engineering, 35, no. 1 (2016):79-86,
https://doi.org/10.20450/mjcce.2016.729 . .

TY  - JOUR
AU  - Nikolić, Miloš V.
AU  - Mijajlović, Marina Ž.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Milovanović, Jelena
AU  - Arsenijević, Aleksandar
AU  - Stojanović, Bojana
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1068
AB  - The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (12), ethyl (L3), propyl (IA) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, 026 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells. (C) 2016 Elsevier B.V. All rights reserved.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid
VL  - 1116
SP  - 264
EP  - 271
DO  - 10.1016/j.molstruc.2016.03.058
ER  - 

@article{
author = "Nikolić, Miloš V. and Mijajlović, Marina Ž. and Jevtić, Verica V. and Ratković, Zoran R. and Novaković, Slađana B. and Bogdanović, Goran A. and Milovanović, Jelena and Arsenijević, Aleksandar and Stojanović, Bojana and Trifunović, Srećko R. and Radić, Gordana P.",
year = "2016",
abstract = "The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (12), ethyl (L3), propyl (IA) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, 026 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells. (C) 2016 Elsevier B.V. All rights reserved.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid",
volume = "1116",
pages = "264-271",
doi = "10.1016/j.molstruc.2016.03.058"
}

Nikolić, M. V., Mijajlović, M. Ž., Jevtić, V. V., Ratković, Z. R., Novaković, S. B., Bogdanović, G. A., Milovanović, J., Arsenijević, A., Stojanović, B., Trifunović, S. R.,& Radić, G. P.. (2016). Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid. in Journal of Molecular Structure
Elsevier., 1116, 264-271.
https://doi.org/10.1016/j.molstruc.2016.03.058

Nikolić MV, Mijajlović MŽ, Jevtić VV, Ratković ZR, Novaković SB, Bogdanović GA, Milovanović J, Arsenijević A, Stojanović B, Trifunović SR, Radić GP. Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid. in Journal of Molecular Structure. 2016;1116:264-271.
doi:10.1016/j.molstruc.2016.03.058 .

Nikolić, Miloš V., Mijajlović, Marina Ž., Jevtić, Verica V., Ratković, Zoran R., Novaković, Slađana B., Bogdanović, Goran A., Milovanović, Jelena, Arsenijević, Aleksandar, Stojanović, Bojana, Trifunović, Srećko R., Radić, Gordana P., "Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid" in Journal of Molecular Structure, 1116 (2016):264-271,
https://doi.org/10.1016/j.molstruc.2016.03.058 . .

TY  - JOUR
AU  - Mijajlović, Marina Ž.
AU  - Nikolić, Miloš V.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Marković-Simović, Bojana
AU  - Volarevic, Vladislav
AU  - Arsenijević, Nebojša N.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/497
AB  - The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)(2)] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-thiosalicylic acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands. (C) 2015 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]
VL  - 90
SP  - 34
EP  - 40
DO  - 10.1016/j.poly.2015.01.041
ER  - 

@article{
author = "Mijajlović, Marina Ž. and Nikolić, Miloš V. and Jevtić, Verica V. and Ratković, Zoran R. and Marković-Simović, Bojana and Volarevic, Vladislav and Arsenijević, Nebojša N. and Novaković, Slađana B. and Bogdanović, Goran A. and Trifunović, Srećko R. and Radić, Gordana P.",
year = "2015",
abstract = "The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)(2)] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-thiosalicylic acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands. (C) 2015 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]",
volume = "90",
pages = "34-40",
doi = "10.1016/j.poly.2015.01.041"
}

Mijajlović, M. Ž., Nikolić, M. V., Jevtić, V. V., Ratković, Z. R., Marković-Simović, B., Volarevic, V., Arsenijević, N. N., Novaković, S. B., Bogdanović, G. A., Trifunović, S. R.,& Radić, G. P.. (2015). Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]. in Polyhedron, 90, 34-40.
https://doi.org/10.1016/j.poly.2015.01.041

Mijajlović MŽ, Nikolić MV, Jevtić VV, Ratković ZR, Marković-Simović B, Volarevic V, Arsenijević NN, Novaković SB, Bogdanović GA, Trifunović SR, Radić GP. Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]. in Polyhedron. 2015;90:34-40.
doi:10.1016/j.poly.2015.01.041 .

Mijajlović, Marina Ž., Nikolić, Miloš V., Jevtić, Verica V., Ratković, Zoran R., Marković-Simović, Bojana, Volarevic, Vladislav, Arsenijević, Nebojša N., Novaković, Slađana B., Bogdanović, Goran A., Trifunović, Srećko R., Radić, Gordana P., "Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)(2)]" in Polyhedron, 90 (2015):34-40,
https://doi.org/10.1016/j.poly.2015.01.041 . .

TY  - JOUR
AU  - Ilić, Dragoslav
AU  - Jevtić, Verica V.
AU  - Vasojevic, Miorad M.
AU  - Jelic, Miodrag Z.
AU  - Radojevic, Ivana D.
AU  - Čomić, Ljiljana R.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Potocnak, Ivan
AU  - Trifunović, Srećko R.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/342
AB  - The octahedral cobalt(III) complexes with (S,S)-ethylenediamine-N,N-di-2-propionic (S,S-eddp) and (S,S)-ethylenediamine-N,N-di-2-(3-methyl)-butanoic (S,S-eddv) acids and oxalato and malonato ligands, as additional bidentate ligands, were prepared and characterized. The complexes were purified by ionexchange chromatography. The geometry of the complexes has been supposed on the basis of the infrared, electronic absorption and NMR spectra. The A absolute configurations of the isolated complexes have been predicted on the basis of their circular dichroism (CD) spectra and it was confirmed by single-crystal X-ray analysis of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N-di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O. Antimicrobial activity of ligands and obtained cobalt(III) complexes was evaluated by determining the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) in relation to 13 species of microorganisms (five strains of pathogenic bacteria, five species pathogenic fungi and three species of probiotic). Tested ligands and complexes demonstrated moderate and low antibacterial and antifungal activity. There was no difference in activities between the ligands and complexes. (C) 2014 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Stereospecific ligands and their complexes. Part XXI. Synthesis, characterization, circular dichroism and antimicrobial activity of cobalt(III) complexes with some edda-type of ligands. Crystal structure of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N -di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O
VL  - 85
SP  - 1
EP  - 9
DO  - 10.1016/j.poly.2014.08.013
ER  - 

@article{
author = "Ilić, Dragoslav and Jevtić, Verica V. and Vasojevic, Miorad M. and Jelic, Miodrag Z. and Radojevic, Ivana D. and Čomić, Ljiljana R. and Novaković, Slađana B. and Bogdanović, Goran A. and Potocnak, Ivan and Trifunović, Srećko R.",
year = "2015",
abstract = "The octahedral cobalt(III) complexes with (S,S)-ethylenediamine-N,N-di-2-propionic (S,S-eddp) and (S,S)-ethylenediamine-N,N-di-2-(3-methyl)-butanoic (S,S-eddv) acids and oxalato and malonato ligands, as additional bidentate ligands, were prepared and characterized. The complexes were purified by ionexchange chromatography. The geometry of the complexes has been supposed on the basis of the infrared, electronic absorption and NMR spectra. The A absolute configurations of the isolated complexes have been predicted on the basis of their circular dichroism (CD) spectra and it was confirmed by single-crystal X-ray analysis of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N-di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O. Antimicrobial activity of ligands and obtained cobalt(III) complexes was evaluated by determining the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) in relation to 13 species of microorganisms (five strains of pathogenic bacteria, five species pathogenic fungi and three species of probiotic). Tested ligands and complexes demonstrated moderate and low antibacterial and antifungal activity. There was no difference in activities between the ligands and complexes. (C) 2014 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Stereospecific ligands and their complexes. Part XXI. Synthesis, characterization, circular dichroism and antimicrobial activity of cobalt(III) complexes with some edda-type of ligands. Crystal structure of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N -di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O",
volume = "85",
pages = "1-9",
doi = "10.1016/j.poly.2014.08.013"
}

Ilić, D., Jevtić, V. V., Vasojevic, M. M., Jelic, M. Z., Radojevic, I. D., Čomić, L. R., Novaković, S. B., Bogdanović, G. A., Potocnak, I.,& Trifunović, S. R.. (2015). Stereospecific ligands and their complexes. Part XXI. Synthesis, characterization, circular dichroism and antimicrobial activity of cobalt(III) complexes with some edda-type of ligands. Crystal structure of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N -di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O. in Polyhedron, 85, 1-9.
https://doi.org/10.1016/j.poly.2014.08.013

Ilić D, Jevtić VV, Vasojevic MM, Jelic MZ, Radojevic ID, Čomić LR, Novaković SB, Bogdanović GA, Potocnak I, Trifunović SR. Stereospecific ligands and their complexes. Part XXI. Synthesis, characterization, circular dichroism and antimicrobial activity of cobalt(III) complexes with some edda-type of ligands. Crystal structure of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N -di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O. in Polyhedron. 2015;85:1-9.
doi:10.1016/j.poly.2014.08.013 .

Ilić, Dragoslav, Jevtić, Verica V., Vasojevic, Miorad M., Jelic, Miodrag Z., Radojevic, Ivana D., Čomić, Ljiljana R., Novaković, Slađana B., Bogdanović, Goran A., Potocnak, Ivan, Trifunović, Srećko R., "Stereospecific ligands and their complexes. Part XXI. Synthesis, characterization, circular dichroism and antimicrobial activity of cobalt(III) complexes with some edda-type of ligands. Crystal structure of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N -di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O" in Polyhedron, 85 (2015):1-9,
https://doi.org/10.1016/j.poly.2014.08.013 . .

TY  - JOUR
AU  - Nikolić, Miloš V.
AU  - Mijajlović, Marina Ž.
AU  - Jevtić, Verica V.
AU  - Ratković, Zoran R.
AU  - Radojevic, Ivana D.
AU  - Čomić, Ljiljana R.
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Radić, Gordana P.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/106
AB  - The five new copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4), butyl (L5)) have been synthesized and characterized by microanalysis and infrared spectra. The spectroscopically predicted structure of the obtained binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid was confirmed by X-ray analysis. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. The compound crystallizes with two binuclear Cu(II) complex molecules in the asymmetric unit. Both molecules have typical paddle-wheel structure with apical positions occupied by water molecules. The independent molecules showed slight difference in configuration mainly reflected in the different orientation of the phenyl rings relating to their carboxylate groups. Antimicrobial activity of these complexes was tested by microdilution method and both minimal inhibitory and microbicidal concentration were determined. The intensity of the antimicrobial activity varied depending on the species of microorganism and the compound type. In general, the activity of the complexes was higher than or similar to the corresponding ligands. All the tested complexes demonstrated moderate or selective antibacterial activity and low antifungal activity. (C) 2014 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Synthesis, characterization and antimicrobial activity of copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid
VL  - 79
SP  - 80
EP  - 87
DO  - 10.1016/j.poly.2014.04.053
ER  - 

@article{
author = "Nikolić, Miloš V. and Mijajlović, Marina Ž. and Jevtić, Verica V. and Ratković, Zoran R. and Radojevic, Ivana D. and Čomić, Ljiljana R. and Novaković, Slađana B. and Bogdanović, Goran A. and Trifunović, Srećko R. and Radić, Gordana P.",
year = "2014",
abstract = "The five new copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4), butyl (L5)) have been synthesized and characterized by microanalysis and infrared spectra. The spectroscopically predicted structure of the obtained binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid was confirmed by X-ray analysis. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. The compound crystallizes with two binuclear Cu(II) complex molecules in the asymmetric unit. Both molecules have typical paddle-wheel structure with apical positions occupied by water molecules. The independent molecules showed slight difference in configuration mainly reflected in the different orientation of the phenyl rings relating to their carboxylate groups. Antimicrobial activity of these complexes was tested by microdilution method and both minimal inhibitory and microbicidal concentration were determined. The intensity of the antimicrobial activity varied depending on the species of microorganism and the compound type. In general, the activity of the complexes was higher than or similar to the corresponding ligands. All the tested complexes demonstrated moderate or selective antibacterial activity and low antifungal activity. (C) 2014 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Synthesis, characterization and antimicrobial activity of copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid",
volume = "79",
pages = "80-87",
doi = "10.1016/j.poly.2014.04.053"
}

Nikolić, M. V., Mijajlović, M. Ž., Jevtić, V. V., Ratković, Z. R., Radojevic, I. D., Čomić, L. R., Novaković, S. B., Bogdanović, G. A., Trifunović, S. R.,& Radić, G. P.. (2014). Synthesis, characterization and antimicrobial activity of copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid. in Polyhedron, 79, 80-87.
https://doi.org/10.1016/j.poly.2014.04.053

Nikolić MV, Mijajlović MŽ, Jevtić VV, Ratković ZR, Radojevic ID, Čomić LR, Novaković SB, Bogdanović GA, Trifunović SR, Radić GP. Synthesis, characterization and antimicrobial activity of copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid. in Polyhedron. 2014;79:80-87.
doi:10.1016/j.poly.2014.04.053 .

Nikolić, Miloš V., Mijajlović, Marina Ž., Jevtić, Verica V., Ratković, Zoran R., Radojevic, Ivana D., Čomić, Ljiljana R., Novaković, Slađana B., Bogdanović, Goran A., Trifunović, Srećko R., Radić, Gordana P., "Synthesis, characterization and antimicrobial activity of copper(II) complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II) complex with S-methyl derivative of thiosalicylic acid" in Polyhedron, 79 (2014):80-87,
https://doi.org/10.1016/j.poly.2014.04.053 . .

TY  - JOUR
AU  - Vujic, Jelena M.
AU  - Garcia-Granda, Santiago
AU  - Menendez-Taboada, Laura
AU  - Novaković, Slađana B.
AU  - Trifunović, Srećko R.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5295
AB  - The bidentate N,N-ligand precursor, the O,O-dipropyl ester of N,N,N-1,2-ethanediyIbis-L-leucine, dihydrochloride, [(S,S)-H(4)eddl]Cl-2, was prepared and its crystal structure is given herein. It crystallizes in a P4(2) space group of a tetragonal crystal system with a = 16.5620 (2) angstrom, b = 16.5620 (2) angstrom, c 5.2240 (1) angstrom and Z = 2.
T2  - Journal of the Serbian Chemical Society
T1  - Stereospecific ligands and their complexes. Part XIV. Crystal structure of the O,O -dipropyl ester of N,N -1,2-ethanediylbis-L-leucine, dihydrochloride
VL  - 78
IS  - 1
SP  - 57
EP  - 63
DO  - 10.2298/JSC120208041V
ER  - 

@article{
author = "Vujic, Jelena M. and Garcia-Granda, Santiago and Menendez-Taboada, Laura and Novaković, Slađana B. and Trifunović, Srećko R.",
year = "2013",
abstract = "The bidentate N,N-ligand precursor, the O,O-dipropyl ester of N,N,N-1,2-ethanediyIbis-L-leucine, dihydrochloride, [(S,S)-H(4)eddl]Cl-2, was prepared and its crystal structure is given herein. It crystallizes in a P4(2) space group of a tetragonal crystal system with a = 16.5620 (2) angstrom, b = 16.5620 (2) angstrom, c 5.2240 (1) angstrom and Z = 2.",
journal = "Journal of the Serbian Chemical Society",
title = "Stereospecific ligands and their complexes. Part XIV. Crystal structure of the O,O -dipropyl ester of N,N -1,2-ethanediylbis-L-leucine, dihydrochloride",
volume = "78",
number = "1",
pages = "57-63",
doi = "10.2298/JSC120208041V"
}

Vujic, J. M., Garcia-Granda, S., Menendez-Taboada, L., Novaković, S. B.,& Trifunović, S. R.. (2013). Stereospecific ligands and their complexes. Part XIV. Crystal structure of the O,O -dipropyl ester of N,N -1,2-ethanediylbis-L-leucine, dihydrochloride. in Journal of the Serbian Chemical Society, 78(1), 57-63.
https://doi.org/10.2298/JSC120208041V

Vujic JM, Garcia-Granda S, Menendez-Taboada L, Novaković SB, Trifunović SR. Stereospecific ligands and their complexes. Part XIV. Crystal structure of the O,O -dipropyl ester of N,N -1,2-ethanediylbis-L-leucine, dihydrochloride. in Journal of the Serbian Chemical Society. 2013;78(1):57-63.
doi:10.2298/JSC120208041V .

Vujic, Jelena M., Garcia-Granda, Santiago, Menendez-Taboada, Laura, Novaković, Slađana B., Trifunović, Srećko R., "Stereospecific ligands and their complexes. Part XIV. Crystal structure of the O,O -dipropyl ester of N,N -1,2-ethanediylbis-L-leucine, dihydrochloride" in Journal of the Serbian Chemical Society, 78, no. 1 (2013):57-63,
https://doi.org/10.2298/JSC120208041V . .

TY  - JOUR
AU  - Dimitrijevic, Dejana P.
AU  - Glodovic, Verica V.
AU  - Radić, Gordana P.
AU  - Garcia-Granda, Santiago
AU  - Menendez-Taboada, Laura
AU  - Milovanović, Marija
AU  - Volarevic, Vladislav
AU  - Arsenijević, Nebojša N.
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5556
AB  - The synthesis of ethylenediamine-N,N-di-S,S-(2,2-dibenzyl)acetic acid (H-2-S,S-eddba) and its ethyl-, propyl-, butyl-esters (R-2-S,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R-2-S,S-eddba)]. The compounds were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The structure of propyl ester of H-2-S,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R-2-S,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin. (C) 2013 Published by Elsevier B.V.
T2  - Inorganica Chimica Acta
T1  - Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride
VL  - 402
SP  - 83
EP  - 89
DO  - 10.1016/j.ica.2013.03.039
ER  - 

@article{
author = "Dimitrijevic, Dejana P. and Glodovic, Verica V. and Radić, Gordana P. and Garcia-Granda, Santiago and Menendez-Taboada, Laura and Milovanović, Marija and Volarevic, Vladislav and Arsenijević, Nebojša N. and Bogdanović, Goran A. and Trifunović, Srećko R.",
year = "2013",
abstract = "The synthesis of ethylenediamine-N,N-di-S,S-(2,2-dibenzyl)acetic acid (H-2-S,S-eddba) and its ethyl-, propyl-, butyl-esters (R-2-S,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R-2-S,S-eddba)]. The compounds were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The structure of propyl ester of H-2-S,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R-2-S,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin. (C) 2013 Published by Elsevier B.V.",
journal = "Inorganica Chimica Acta",
title = "Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride",
volume = "402",
pages = "83-89",
doi = "10.1016/j.ica.2013.03.039"
}

Dimitrijevic, D. P., Glodovic, V. V., Radić, G. P., Garcia-Granda, S., Menendez-Taboada, L., Milovanović, M., Volarevic, V., Arsenijević, N. N., Bogdanović, G. A.,& Trifunović, S. R.. (2013). Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride. in Inorganica Chimica Acta, 402, 83-89.
https://doi.org/10.1016/j.ica.2013.03.039

Dimitrijevic DP, Glodovic VV, Radić GP, Garcia-Granda S, Menendez-Taboada L, Milovanović M, Volarevic V, Arsenijević NN, Bogdanović GA, Trifunović SR. Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride. in Inorganica Chimica Acta. 2013;402:83-89.
doi:10.1016/j.ica.2013.03.039 .

Dimitrijevic, Dejana P., Glodovic, Verica V., Radić, Gordana P., Garcia-Granda, Santiago, Menendez-Taboada, Laura, Milovanović, Marija, Volarevic, Vladislav, Arsenijević, Nebojša N., Bogdanović, Goran A., Trifunović, Srećko R., "Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetic acid. Crystal structure of O,O -dipropyl-ethylenediamine-N,N -di-S,S-(2,2 -dibenzyl)acetate dihydrochloride" in Inorganica Chimica Acta, 402 (2013):83-89,
https://doi.org/10.1016/j.ica.2013.03.039 . .

TY  - JOUR
AU  - Dimitrijevic, Dejana P.
AU  - Novaković, Slađana B.
AU  - Radić, Gordana R.
AU  - Jevtić, Verica V.
AU  - Menendez-Taboada, Laura
AU  - Garcia-Granda, Santiago
AU  - Trifunović, Srećko R.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5760
AB  - The synthesis of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride is reported here. The compound was characterized by elemental analysis, infrared, and H-1- and C-13-NMR spectroscopy. The structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride was continued by single-crystal X-ray analysis.
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, characterization and crystal structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride
VL  - 78
IS  - 10
SP  - 1531
EP  - 1537
DO  - 10.2298/JSC130214054D
ER  - 

@article{
author = "Dimitrijevic, Dejana P. and Novaković, Slađana B. and Radić, Gordana R. and Jevtić, Verica V. and Menendez-Taboada, Laura and Garcia-Granda, Santiago and Trifunović, Srećko R.",
year = "2013",
abstract = "The synthesis of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride is reported here. The compound was characterized by elemental analysis, infrared, and H-1- and C-13-NMR spectroscopy. The structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride was continued by single-crystal X-ray analysis.",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, characterization and crystal structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride",
volume = "78",
number = "10",
pages = "1531-1537",
doi = "10.2298/JSC130214054D"
}

Dimitrijevic, D. P., Novaković, S. B., Radić, G. R., Jevtić, V. V., Menendez-Taboada, L., Garcia-Granda, S.,& Trifunović, S. R.. (2013). Synthesis, characterization and crystal structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride. in Journal of the Serbian Chemical Society, 78(10), 1531-1537.
https://doi.org/10.2298/JSC130214054D

Dimitrijevic DP, Novaković SB, Radić GR, Jevtić VV, Menendez-Taboada L, Garcia-Granda S, Trifunović SR. Synthesis, characterization and crystal structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride. in Journal of the Serbian Chemical Society. 2013;78(10):1531-1537.
doi:10.2298/JSC130214054D .

Dimitrijevic, Dejana P., Novaković, Slađana B., Radić, Gordana R., Jevtić, Verica V., Menendez-Taboada, Laura, Garcia-Granda, Santiago, Trifunović, Srećko R., "Synthesis, characterization and crystal structure of butyl N-(3-chloropropyl)-(2S)-alaninate hydrochloride" in Journal of the Serbian Chemical Society, 78, no. 10 (2013):1531-1537,
https://doi.org/10.2298/JSC130214054D . .

TY  - JOUR
AU  - Radić, Gordana P.
AU  - Glodovic, Verica V.
AU  - Ratković, Zoran R.
AU  - Novaković, Slađana B.
AU  - Garcia-Granda, Santiago
AU  - Roces, Laura
AU  - Menendez-Taboada, Laura
AU  - Radojevic, Ivana D.
AU  - Stefanovic, Olgica D.
AU  - Čomić, Ljiljana R.
AU  - Trifunović, Srećko R.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5197
AB  - In the reaction of meso-1,2-diphenyl-ethylenediamine (1,2-dphen) with neutralized 3-chlor-propanoic acid, the new linear tetradentate edda-like ligand (edda = ethylenediamine-N,N-diacetic ion) meso-1, 2-diphenyl-ethylenediamine-N,N-di-3-propanoic acid dihydrochloride monohydrate (H-2-1,2-dpheddp center dot 2HCl center dot H2O) was prepared. The corresponding platinum(IV) complex, s-cis-dichlorido-(meso-1,2-diphenyl-ethylenediamine-N,N-di-3-propanoate)-platinum(IV) ([PtCl2(1,2-dpheddp)]) was synthesized by heating potassium-hexachloridoplatinate(IV) and H-2-1,2-dpheddp center dot 2HCl center dot H2O on steam bath for 12 h with neutralization by means of lithium-hydroxide. The palladium(II) complex, cis-dichlorido-(meso-1,2diphenyl-ethylenediamine-N,N-di-3-propanoate)-palladium(II) (IPdCl2(1,2-dpheddp)]) was obtained in the similar way using potassium-tetrachloridopalladate(II), H-2-1,2-dpheddp-2HCl center dot H2O and lithium-hydroxide. The compounds were characterized by elemental analysis and infrared spectroscopy. The spectroscopically predicted structure of the synthesized tetradentate ligand was confirmed by X-ray analysis of the H-2-1,2-dpheddp.2HCl center dot H2O. Antimicrobial activity of the ligand and corresponding palladium(II) and platinum(IV) complexes is investigated against 25 species of microorganisms. Testing is preformed by microdilution method and minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of the ligand and corresponding platinum(IV) and palladium(II) complex is noticed and, in general, palladium(II) complex was the most active. (C) 2012 Elsevier B.V. All rights reserved.
T2  - Journal of Molecular Structure
T1  - Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N -di-3-propanoic acid - Crystal structure of H-2-1,2-dpheddp center dot 2HCl center dot H2O
VL  - 1029
SP  - 180
EP  - 186
DO  - 10.1016/j.molstruc.2012.07.007
ER  - 

@article{
author = "Radić, Gordana P. and Glodovic, Verica V. and Ratković, Zoran R. and Novaković, Slađana B. and Garcia-Granda, Santiago and Roces, Laura and Menendez-Taboada, Laura and Radojevic, Ivana D. and Stefanovic, Olgica D. and Čomić, Ljiljana R. and Trifunović, Srećko R.",
year = "2012",
abstract = "In the reaction of meso-1,2-diphenyl-ethylenediamine (1,2-dphen) with neutralized 3-chlor-propanoic acid, the new linear tetradentate edda-like ligand (edda = ethylenediamine-N,N-diacetic ion) meso-1, 2-diphenyl-ethylenediamine-N,N-di-3-propanoic acid dihydrochloride monohydrate (H-2-1,2-dpheddp center dot 2HCl center dot H2O) was prepared. The corresponding platinum(IV) complex, s-cis-dichlorido-(meso-1,2-diphenyl-ethylenediamine-N,N-di-3-propanoate)-platinum(IV) ([PtCl2(1,2-dpheddp)]) was synthesized by heating potassium-hexachloridoplatinate(IV) and H-2-1,2-dpheddp center dot 2HCl center dot H2O on steam bath for 12 h with neutralization by means of lithium-hydroxide. The palladium(II) complex, cis-dichlorido-(meso-1,2diphenyl-ethylenediamine-N,N-di-3-propanoate)-palladium(II) (IPdCl2(1,2-dpheddp)]) was obtained in the similar way using potassium-tetrachloridopalladate(II), H-2-1,2-dpheddp-2HCl center dot H2O and lithium-hydroxide. The compounds were characterized by elemental analysis and infrared spectroscopy. The spectroscopically predicted structure of the synthesized tetradentate ligand was confirmed by X-ray analysis of the H-2-1,2-dpheddp.2HCl center dot H2O. Antimicrobial activity of the ligand and corresponding palladium(II) and platinum(IV) complexes is investigated against 25 species of microorganisms. Testing is preformed by microdilution method and minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of the ligand and corresponding platinum(IV) and palladium(II) complex is noticed and, in general, palladium(II) complex was the most active. (C) 2012 Elsevier B.V. All rights reserved.",
journal = "Journal of Molecular Structure",
title = "Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N -di-3-propanoic acid - Crystal structure of H-2-1,2-dpheddp center dot 2HCl center dot H2O",
volume = "1029",
pages = "180-186",
doi = "10.1016/j.molstruc.2012.07.007"
}

Radić, G. P., Glodovic, V. V., Ratković, Z. R., Novaković, S. B., Garcia-Granda, S., Roces, L., Menendez-Taboada, L., Radojevic, I. D., Stefanovic, O. D., Čomić, L. R.,& Trifunović, S. R.. (2012). Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N -di-3-propanoic acid - Crystal structure of H-2-1,2-dpheddp center dot 2HCl center dot H2O. in Journal of Molecular Structure, 1029, 180-186.
https://doi.org/10.1016/j.molstruc.2012.07.007

Radić GP, Glodovic VV, Ratković ZR, Novaković SB, Garcia-Granda S, Roces L, Menendez-Taboada L, Radojevic ID, Stefanovic OD, Čomić LR, Trifunović SR. Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N -di-3-propanoic acid - Crystal structure of H-2-1,2-dpheddp center dot 2HCl center dot H2O. in Journal of Molecular Structure. 2012;1029:180-186.
doi:10.1016/j.molstruc.2012.07.007 .

Radić, Gordana P., Glodovic, Verica V., Ratković, Zoran R., Novaković, Slađana B., Garcia-Granda, Santiago, Roces, Laura, Menendez-Taboada, Laura, Radojevic, Ivana D., Stefanovic, Olgica D., Čomić, Ljiljana R., Trifunović, Srećko R., "Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N -di-3-propanoic acid - Crystal structure of H-2-1,2-dpheddp center dot 2HCl center dot H2O" in Journal of Molecular Structure, 1029 (2012):180-186,
https://doi.org/10.1016/j.molstruc.2012.07.007 . .