TY  - JOUR
AU  - Lakić, Mladen
AU  - Anđelković, Ljubica
AU  - Šuljagić, Marija
AU  - Vulić, Predrag
AU  - Perić, Marko R.
AU  - Iskrenović, Predrag
AU  - Krstić, Ivan
AU  - Kuraica, Milorad M.
AU  - Nikolić, Aleksandar S.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0925346719301995
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8114
AB  - Light-transmitting measurements of white light and a consequentially chosen laser beam of 655 nm propagating through citrate- and oleate-coated CoFe 2 O 4 , FeFe 2 O 4 and MgFe 2 O 4 nanoparticles under the influence of an external magnetic field were presented. New experimental settings were developed for the optical study of ferrites’ behavior in ferrofluid with the applied magnetic field strength within the 30–400 mT range. A magnetic field-induced change of light transmittance occurred and a precipitation of all studied samples was obtained. Optical investigations of ferrofluid suspensions revealed that, contrary to the linear aggregates of colloidal CoFe 2 O 4 and FeFe 2 O 4 , spheroidal aggregates were formed in the case of MgFe 2 O 4 . In all three cases, the surface modification resulted in decreased dipole–dipole interactions between ferrite cores, and thus, less precipitates were noticed. All oleate-coated nanoparticles have demonstrated weaker magnetic responses compared to the citrate-encapsulated samples. The aggregation of nanoparticles potentially increases cytotoxicity. Regarding non-linear clustering of MgFe 2 O 4 suspensions, it can be concluded that its excretion from the organism may likely be easier and faster when used in diagnosis and/or therapy. Therefore, more attention should be paid to the lowly toxic MgFe 2 O 4 regarding its medical application. © 2019
T2  - Optical Materials
T1  - Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite
VL  - 91
SP  - 279
EP  - 285
DO  - 10.1016/j.optmat.2019.03.031
ER  - 

@article{
author = "Lakić, Mladen and Anđelković, Ljubica and Šuljagić, Marija and Vulić, Predrag and Perić, Marko R. and Iskrenović, Predrag and Krstić, Ivan and Kuraica, Milorad M. and Nikolić, Aleksandar S.",
year = "2019",
abstract = "Light-transmitting measurements of white light and a consequentially chosen laser beam of 655 nm propagating through citrate- and oleate-coated CoFe 2 O 4 , FeFe 2 O 4 and MgFe 2 O 4 nanoparticles under the influence of an external magnetic field were presented. New experimental settings were developed for the optical study of ferrites’ behavior in ferrofluid with the applied magnetic field strength within the 30–400 mT range. A magnetic field-induced change of light transmittance occurred and a precipitation of all studied samples was obtained. Optical investigations of ferrofluid suspensions revealed that, contrary to the linear aggregates of colloidal CoFe 2 O 4 and FeFe 2 O 4 , spheroidal aggregates were formed in the case of MgFe 2 O 4 . In all three cases, the surface modification resulted in decreased dipole–dipole interactions between ferrite cores, and thus, less precipitates were noticed. All oleate-coated nanoparticles have demonstrated weaker magnetic responses compared to the citrate-encapsulated samples. The aggregation of nanoparticles potentially increases cytotoxicity. Regarding non-linear clustering of MgFe 2 O 4 suspensions, it can be concluded that its excretion from the organism may likely be easier and faster when used in diagnosis and/or therapy. Therefore, more attention should be paid to the lowly toxic MgFe 2 O 4 regarding its medical application. © 2019",
journal = "Optical Materials",
title = "Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite",
volume = "91",
pages = "279-285",
doi = "10.1016/j.optmat.2019.03.031"
}

Lakić, M., Anđelković, L., Šuljagić, M., Vulić, P., Perić, M. R., Iskrenović, P., Krstić, I., Kuraica, M. M.,& Nikolić, A. S.. (2019). Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite. in Optical Materials, 91, 279-285.
https://doi.org/10.1016/j.optmat.2019.03.031

Lakić M, Anđelković L, Šuljagić M, Vulić P, Perić MR, Iskrenović P, Krstić I, Kuraica MM, Nikolić AS. Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite. in Optical Materials. 2019;91:279-285.
doi:10.1016/j.optmat.2019.03.031 .

Lakić, Mladen, Anđelković, Ljubica, Šuljagić, Marija, Vulić, Predrag, Perić, Marko R., Iskrenović, Predrag, Krstić, Ivan, Kuraica, Milorad M., Nikolić, Aleksandar S., "Optical evidence of magnetic field-induced ferrofluid aggregation: Comparison of cobalt ferrite, magnetite, and magnesium ferrite" in Optical Materials, 91 (2019):279-285,
https://doi.org/10.1016/j.optmat.2019.03.031 . .

TY  - JOUR
AU  - Lakić, Mladen
AU  - Sabo, Ljubica
AU  - Ristic, Slavica
AU  - Savić, Aleksandar
AU  - Petricevic, Sasa
AU  - Nikolić, Nadežda S.
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Sabo, Tibor J.
AU  - Vranješ-Đurić, Sanja
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/273
AB  - The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O-diethylethylenediamine-N,N-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L) and diacid ligand (L), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley and Sons, Ltd.
T2  - Applied Organometallic Chemistry
T1  - Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent
VL  - 30
IS  - 2
SP  - 81
EP  - 88
DO  - 10.1002/aoc.3401
ER  - 

@article{
author = "Lakić, Mladen and Sabo, Ljubica and Ristic, Slavica and Savić, Aleksandar and Petricevic, Sasa and Nikolić, Nadežda S. and Vukadinović, Aleksandar and Janković, Drina and Sabo, Tibor J. and Vranješ-Đurić, Sanja",
year = "2016",
abstract = "The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O-diethylethylenediamine-N,N-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L) and diacid ligand (L), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley and Sons, Ltd.",
journal = "Applied Organometallic Chemistry",
title = "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent",
volume = "30",
number = "2",
pages = "81-88",
doi = "10.1002/aoc.3401"
}

Lakić, M., Sabo, L., Ristic, S., Savić, A., Petricevic, S., Nikolić, N. S., Vukadinović, A., Janković, D., Sabo, T. J.,& Vranješ-Đurić, S.. (2016). Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry, 30(2), 81-88.
https://doi.org/10.1002/aoc.3401

Lakić M, Sabo L, Ristic S, Savić A, Petricevic S, Nikolić NS, Vukadinović A, Janković D, Sabo TJ, Vranješ-Đurić S. Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry. 2016;30(2):81-88.
doi:10.1002/aoc.3401 .

Lakić, Mladen, Sabo, Ljubica, Ristic, Slavica, Savić, Aleksandar, Petricevic, Sasa, Nikolić, Nadežda S., Vukadinović, Aleksandar, Janković, Drina, Sabo, Tibor J., Vranješ-Đurić, Sanja, "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent" in Applied Organometallic Chemistry, 30, no. 2 (2016):81-88,
https://doi.org/10.1002/aoc.3401 . .

TY  - JOUR
AU  - Lakić, Mladen
AU  - Vukadinović, Aleksandar
AU  - Kalcher, Kurt
AU  - Nikolić, Aleksandar S.
AU  - Stanković, Dalibor M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1292
AB  - This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.
T2  - Talanta
T1  - Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone
VL  - 161
SP  - 668
EP  - 674
DO  - 10.1016/j.talanta.2016.09.029
ER  - 

@article{
author = "Lakić, Mladen and Vukadinović, Aleksandar and Kalcher, Kurt and Nikolić, Aleksandar S. and Stanković, Dalibor M.",
year = "2016",
abstract = "This work presents the simultaneous determination of catechol (CC) and hydroquinone (HQ), employing a modified carbon paste electrode (CPE) with ferrite nanomaterial. Ferrite nanomaterial was doped with different amount of cobalt and this was investigated toward simultaneous oxidation of CC and HQ. It was shown that this modification strongly increases electrochemical characteristics of the CPE. Also, electrocatalytic activity of such materials strongly depends on the level of substituted Co in the ferrite nanoparticles. The modified electrodes, labeled as CoFerrite/CPE, showed two pairs of well-defined redox peaks for the electrochemical processes of catechol and hydroquinone. Involving of ferrite material in the structure of CPE, cause increase in the potentials differences between redox couples of the investigated compounds, accompanied with increases in peaks currents. Several important parameters were optimized and calibration curves, with limits of detection (LOD) of 0.15 and 0.3 mu M for catechol and hydroquinone, respectively, were constructed by employing amperometric detection. Effect of possible interfering compounds was also studied, and proposed method was successfully applied for CC and HQ quantification in real samples.",
journal = "Talanta",
title = "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone",
volume = "161",
pages = "668-674",
doi = "10.1016/j.talanta.2016.09.029"
}

Lakić, M., Vukadinović, A., Kalcher, K., Nikolić, A. S.,& Stanković, D. M.. (2016). Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta, 161, 668-674.
https://doi.org/10.1016/j.talanta.2016.09.029

Lakić M, Vukadinović A, Kalcher K, Nikolić AS, Stanković DM. Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone. in Talanta. 2016;161:668-674.
doi:10.1016/j.talanta.2016.09.029 .

Lakić, Mladen, Vukadinović, Aleksandar, Kalcher, Kurt, Nikolić, Aleksandar S., Stanković, Dalibor M., "Effect of cobalt doping level of ferrites in enhancing sensitivity of analytical performances of carbon paste electrode for simultaneous determination of catechol and hydroquinone" in Talanta, 161 (2016):668-674,
https://doi.org/10.1016/j.talanta.2016.09.029 . .

TY  - CONF
AU  - Janković, Drina
AU  - Vranješ-Đurić, Sanja
AU  - Marković, Mirjana
AU  - Mirković, Marija D.
AU  - Stanković, Dalibor M.
AU  - Lakić, Mladen
AU  - Nikolić, Nadežda S.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9359
AB  - In this study, tin fluoride colloid (SnF-c) was prepared, labeled with 90Y and characterized with respect to its physicochemical properties. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of NaF, temperature and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90Y-SnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 oC. Due to high labeling yield and stability, 90Y-SnF-c might be a promising agent for radiosynovectomy.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
T1  - Preparation of 90Y-Labeled Tin Fluoride Colloid for Radiosynovectomy
VL  - 2
SP  - 594
EP  - 596
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9359
ER  - 

@conference{
author = "Janković, Drina and Vranješ-Đurić, Sanja and Marković, Mirjana and Mirković, Marija D. and Stanković, Dalibor M. and Lakić, Mladen and Nikolić, Nadežda S.",
year = "2012",
abstract = "In this study, tin fluoride colloid (SnF-c) was prepared, labeled with 90Y and characterized with respect to its physicochemical properties. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of NaF, temperature and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90Y-SnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 oC. Due to high labeling yield and stability, 90Y-SnF-c might be a promising agent for radiosynovectomy.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry",
title = "Preparation of 90Y-Labeled Tin Fluoride Colloid for Radiosynovectomy",
volume = "2",
pages = "594-596",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9359"
}

Janković, D., Vranješ-Đurić, S., Marković, M., Mirković, M. D., Stanković, D. M., Lakić, M.,& Nikolić, N. S.. (2012). Preparation of 90Y-Labeled Tin Fluoride Colloid for Radiosynovectomy. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 2, 594-596.
https://hdl.handle.net/21.15107/rcub_vinar_9359

Janković D, Vranješ-Đurić S, Marković M, Mirković MD, Stanković DM, Lakić M, Nikolić NS. Preparation of 90Y-Labeled Tin Fluoride Colloid for Radiosynovectomy. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;2:594-596.
https://hdl.handle.net/21.15107/rcub_vinar_9359 .

Janković, Drina, Vranješ-Đurić, Sanja, Marković, Mirjana, Mirković, Marija D., Stanković, Dalibor M., Lakić, Mladen, Nikolić, Nadežda S., "Preparation of 90Y-Labeled Tin Fluoride Colloid for Radiosynovectomy" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2 (2012):594-596,
https://hdl.handle.net/21.15107/rcub_vinar_9359 .

TY  - CONF
AU  - Stanković, Dalibor M.
AU  - Janković, Drina
AU  - Mirković, Marija D.
AU  - Lakić, Mladen
AU  - Vranješ-Đurić, Sanja
AU  - Nikolić, Nadežda S.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9353
AB  - The 99mTc-labeling of baclofen (Bac), a muscle relaxant, as well as
physicochemical properties of the labeled compounds are investigated. Two
different approaches for the labeling with 99mTc have been studied: direct reduction
with tin(II)chloride and the 'organometallic approach' using [99mTc(CO)3(H2O)3]
+
precursor. The direct labeling approach was not successful and the yield was poor.
The use of [99mTc(CO)3(H2O)3]+ precursor pointed at the formation of 99mTc(I)
coordinated complexes with high yield. In this approach, pH didn’t influence the
yields. Promising results of in vitro experiments suggest that 99mTc(I)-baclofen may
be of potential use for diagnosis of some central nervous system disorders.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
T1  - Physicochemical evaluation of Technetium-99m complexes with baclofen
VL  - 2
SP  - 591
EP  - 593
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9353
ER  - 

@conference{
author = "Stanković, Dalibor M. and Janković, Drina and Mirković, Marija D. and Lakić, Mladen and Vranješ-Đurić, Sanja and Nikolić, Nadežda S.",
year = "2012",
abstract = "The 99mTc-labeling of baclofen (Bac), a muscle relaxant, as well as
physicochemical properties of the labeled compounds are investigated. Two
different approaches for the labeling with 99mTc have been studied: direct reduction
with tin(II)chloride and the 'organometallic approach' using [99mTc(CO)3(H2O)3]
+
precursor. The direct labeling approach was not successful and the yield was poor.
The use of [99mTc(CO)3(H2O)3]+ precursor pointed at the formation of 99mTc(I)
coordinated complexes with high yield. In this approach, pH didn’t influence the
yields. Promising results of in vitro experiments suggest that 99mTc(I)-baclofen may
be of potential use for diagnosis of some central nervous system disorders.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry",
title = "Physicochemical evaluation of Technetium-99m complexes with baclofen",
volume = "2",
pages = "591-593",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9353"
}

Stanković, D. M., Janković, D., Mirković, M. D., Lakić, M., Vranješ-Đurić, S.,& Nikolić, N. S.. (2012). Physicochemical evaluation of Technetium-99m complexes with baclofen. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 2, 591-593.
https://hdl.handle.net/21.15107/rcub_vinar_9353

Stanković DM, Janković D, Mirković MD, Lakić M, Vranješ-Đurić S, Nikolić NS. Physicochemical evaluation of Technetium-99m complexes with baclofen. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;2:591-593.
https://hdl.handle.net/21.15107/rcub_vinar_9353 .

Stanković, Dalibor M., Janković, Drina, Mirković, Marija D., Lakić, Mladen, Vranješ-Đurić, Sanja, Nikolić, Nadežda S., "Physicochemical evaluation of Technetium-99m complexes with baclofen" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2 (2012):591-593,
https://hdl.handle.net/21.15107/rcub_vinar_9353 .

TY  - CONF
AU  - Lakić, Mladen
AU  - Janković, Drina
AU  - Savić, A.
AU  - Sabo, Lj.
AU  - Sabo, T.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9352
AB  - There is an increasing interest for the 99mTc labeling of biomolecules by using
bifunctional chelating agents like ethylenediamine-N,N´-di-3-propanoate diethyl
ester (deeddp). To find new ligand, which can be linked to the small biomolecules
and coordinated with [99mTc(CO)3(H2O)3]
+
 precursor, is a challenging task.
Radiolabeling of deeddp with [99mTc(CO)3(H2O)3]
+
 precursor, stability studies and
biodistribution of formed complexes were carried out, including challenge with
histidine. Radiochemical yield of 99mTc(I)-tricarbonyl-deeddp complexes was
higher than 95%. These complexes were stable in vitro and showed a very good
biological behavior. The radiochemical and biological features of the novel
99mTc(I)-complexes, as well as, the nature of the ligands, make them very
promising candidates for labeling of tumor specific biomolecules.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
T1  - 99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent
VL  - 2
SP  - 588
EP  - 590
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9352
ER  - 

@conference{
author = "Lakić, Mladen and Janković, Drina and Savić, A. and Sabo, Lj. and Sabo, T.",
year = "2012",
abstract = "There is an increasing interest for the 99mTc labeling of biomolecules by using
bifunctional chelating agents like ethylenediamine-N,N´-di-3-propanoate diethyl
ester (deeddp). To find new ligand, which can be linked to the small biomolecules
and coordinated with [99mTc(CO)3(H2O)3]
+
 precursor, is a challenging task.
Radiolabeling of deeddp with [99mTc(CO)3(H2O)3]
+
 precursor, stability studies and
biodistribution of formed complexes were carried out, including challenge with
histidine. Radiochemical yield of 99mTc(I)-tricarbonyl-deeddp complexes was
higher than 95%. These complexes were stable in vitro and showed a very good
biological behavior. The radiochemical and biological features of the novel
99mTc(I)-complexes, as well as, the nature of the ligands, make them very
promising candidates for labeling of tumor specific biomolecules.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry",
title = "99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent",
volume = "2",
pages = "588-590",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9352"
}

Lakić, M., Janković, D., Savić, A., Sabo, Lj.,& Sabo, T.. (2012). 99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 2, 588-590.
https://hdl.handle.net/21.15107/rcub_vinar_9352

Lakić M, Janković D, Savić A, Sabo L, Sabo T. 99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;2:588-590.
https://hdl.handle.net/21.15107/rcub_vinar_9352 .

Lakić, Mladen, Janković, Drina, Savić, A., Sabo, Lj., Sabo, T., "99MtC(I)-tricarbonyl labeling of ethylene Duamine-N,N'-DI-3-Propanoate diethyl ester as potential radiopharmaceutical agent" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2 (2012):588-590,
https://hdl.handle.net/21.15107/rcub_vinar_9352 .