TY  - JOUR
AU  - Radojkovic, M.
AU  - Ristic, S.
AU  - Colovic, M.
AU  - Cemerikic-Martinovic, V.
AU  - Radojkovic, D.
AU  - Krtolica-Žikić, Koviljka
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3527
AB  - Follicular lymphoma (FL) is characterized by the presence of a t(14; 18) chromosomal translocation that results in overexpression of bcl-2 protein. Bcl-2/IgH gene rearrangement is detected in 80-90% of follicular lymphomas in Western countries. The aim of this study was to analyze the bcl-2/IgH rearrangement in FL lymphoma patients in Serbia, by PCR technique, correlate molecular findings with clinical characteristics and outcome and assess the prognostic significance of these rearrangements. One hundred-seven patients (median age, 54 years; male/female ratio:60/47) diagnosed with FL were included in the study. DNA samples were obtained from paraffin embedded lymphoid tissue of patients. Bcl-2/IgH rearrangement was assessed for the major breakpoint region (MBR), 5MBR and the minor cluster region (mcr) breakpoints by PCR technique. We detected a t(14;18) in 81.3% (87/107) of patients. The distribution of bcl-2-IgH rearrangement was as follows: 88,5% (77/87) in MBR breakpoint, 10,35% (9/87) in 5MBR, whereas mcr bcl-2-IgH rearrangement was observed in one patient (1.15%). No rearrangements were detected in remaining 20 patients (18.7%). This is the first analyses of the frequency of the bcl-2/IgH gene rearrangement in Serbian FL patients, as well as in Eastern European countries. There was no correlation between presence of bcl-2/IgH gene rearrangement and clinical outcome of disease. Incidence of bcl-2/IgH gene rearrangement in Serbian FL patients is relatively high, and similar to frequency in Western countries. Presence of this rearrangement in tumor tissue is not of prognostic significance.
T2  - Neoplasma
T1  - Molecular characteristics and prognostic significance of bcl-2/IgH gene rearrangement in Serbian follicular lymphoma patients
VL  - 55
IS  - 5
SP  - 421
EP  - 427
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3527
ER  - 

@article{
author = "Radojkovic, M. and Ristic, S. and Colovic, M. and Cemerikic-Martinovic, V. and Radojkovic, D. and Krtolica-Žikić, Koviljka",
year = "2008",
abstract = "Follicular lymphoma (FL) is characterized by the presence of a t(14; 18) chromosomal translocation that results in overexpression of bcl-2 protein. Bcl-2/IgH gene rearrangement is detected in 80-90% of follicular lymphomas in Western countries. The aim of this study was to analyze the bcl-2/IgH rearrangement in FL lymphoma patients in Serbia, by PCR technique, correlate molecular findings with clinical characteristics and outcome and assess the prognostic significance of these rearrangements. One hundred-seven patients (median age, 54 years; male/female ratio:60/47) diagnosed with FL were included in the study. DNA samples were obtained from paraffin embedded lymphoid tissue of patients. Bcl-2/IgH rearrangement was assessed for the major breakpoint region (MBR), 5MBR and the minor cluster region (mcr) breakpoints by PCR technique. We detected a t(14;18) in 81.3% (87/107) of patients. The distribution of bcl-2-IgH rearrangement was as follows: 88,5% (77/87) in MBR breakpoint, 10,35% (9/87) in 5MBR, whereas mcr bcl-2-IgH rearrangement was observed in one patient (1.15%). No rearrangements were detected in remaining 20 patients (18.7%). This is the first analyses of the frequency of the bcl-2/IgH gene rearrangement in Serbian FL patients, as well as in Eastern European countries. There was no correlation between presence of bcl-2/IgH gene rearrangement and clinical outcome of disease. Incidence of bcl-2/IgH gene rearrangement in Serbian FL patients is relatively high, and similar to frequency in Western countries. Presence of this rearrangement in tumor tissue is not of prognostic significance.",
journal = "Neoplasma",
title = "Molecular characteristics and prognostic significance of bcl-2/IgH gene rearrangement in Serbian follicular lymphoma patients",
volume = "55",
number = "5",
pages = "421-427",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3527"
}

Radojkovic, M., Ristic, S., Colovic, M., Cemerikic-Martinovic, V., Radojkovic, D.,& Krtolica-Žikić, K.. (2008). Molecular characteristics and prognostic significance of bcl-2/IgH gene rearrangement in Serbian follicular lymphoma patients. in Neoplasma, 55(5), 421-427.
https://hdl.handle.net/21.15107/rcub_vinar_3527

Radojkovic M, Ristic S, Colovic M, Cemerikic-Martinovic V, Radojkovic D, Krtolica-Žikić K. Molecular characteristics and prognostic significance of bcl-2/IgH gene rearrangement in Serbian follicular lymphoma patients. in Neoplasma. 2008;55(5):421-427.
https://hdl.handle.net/21.15107/rcub_vinar_3527 .

Radojkovic, M., Ristic, S., Colovic, M., Cemerikic-Martinovic, V., Radojkovic, D., Krtolica-Žikić, Koviljka, "Molecular characteristics and prognostic significance of bcl-2/IgH gene rearrangement in Serbian follicular lymphoma patients" in Neoplasma, 55, no. 5 (2008):421-427,
https://hdl.handle.net/21.15107/rcub_vinar_3527 .