Response of NIH 3T3 fibroblast cells on laser-induced periodic surface structures on a 15×(Ti/Zr)/Si multilayer system
Autori
Petrović, SuzanaPeruško, Davor
Mimidis, Alexandros
Kavatzikidou, Paraskevi
Kovač, Janez
Ranella, Anthi
Novaković, Mirjana M.
Popović, Maja
Stratakis, Emmanuel
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Ultrafast laser processing with the formation of periodic surface nanostructures on the 15×(Ti/Zr)/Si multilayers is studied in order to the improve cell response. A novel nanocomposite structure in the form of 15x(Ti/Zr)/Si multilayer thin films, with satisfying mechanical properties and moderate biocompatibility, was deposited by ion sputtering on an Si substrate. The multilayer 15×(Ti/Zr)/Si thin films were modified by femtosecond laser pulses in air to induce the following modifications: (i) mixing of components inside of the multilayer structures, (ii) the formation of an ultrathin oxide layer at the surfaces, and (iii) surface nano-texturing with the creation of laser-induced periodic surface structure (LIPSS). The focus of this study was an examination of the novel Ti/Zr multilayer thin films in order to create a surface texture with suitable composition and structure for cell integration. Using the SEM and confocal microscopies of the laser-modified Ti/Zr surfaces with seeded c...ell culture (NIH 3T3 fibroblasts), it was found that cell adhesion and growth depend on the surface composition and morphological patterns. These results indicated a good proliferation of cells after two and four days with some tendency of the cell orientation along the LIPSSs. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Ključne reči:
Cell response / Laser-induced periodic surface structure / Multilayer thin film / Ultrafast laser processingIzvor:
Nanomaterials, 2020, 10, 12, 1-14Finansiranje / projekti:
- NFFA-Europe - Nanoscience Foundries and Fine Analysis - Europe (EU-H2020-654360)
- Ministry of Education, Science and Technological Development of the Republic of Serbia
DOI: 10.3390/nano10122531
ISSN: 2079-4991
WoS: 000602452600001
Scopus: 2-s2.0-85097910967
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Petrović, Suzana AU - Peruško, Davor AU - Mimidis, Alexandros AU - Kavatzikidou, Paraskevi AU - Kovač, Janez AU - Ranella, Anthi AU - Novaković, Mirjana M. AU - Popović, Maja AU - Stratakis, Emmanuel PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9785 AB - Ultrafast laser processing with the formation of periodic surface nanostructures on the 15×(Ti/Zr)/Si multilayers is studied in order to the improve cell response. A novel nanocomposite structure in the form of 15x(Ti/Zr)/Si multilayer thin films, with satisfying mechanical properties and moderate biocompatibility, was deposited by ion sputtering on an Si substrate. The multilayer 15×(Ti/Zr)/Si thin films were modified by femtosecond laser pulses in air to induce the following modifications: (i) mixing of components inside of the multilayer structures, (ii) the formation of an ultrathin oxide layer at the surfaces, and (iii) surface nano-texturing with the creation of laser-induced periodic surface structure (LIPSS). The focus of this study was an examination of the novel Ti/Zr multilayer thin films in order to create a surface texture with suitable composition and structure for cell integration. Using the SEM and confocal microscopies of the laser-modified Ti/Zr surfaces with seeded cell culture (NIH 3T3 fibroblasts), it was found that cell adhesion and growth depend on the surface composition and morphological patterns. These results indicated a good proliferation of cells after two and four days with some tendency of the cell orientation along the LIPSSs. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. T2 - Nanomaterials T1 - Response of NIH 3T3 fibroblast cells on laser-induced periodic surface structures on a 15×(Ti/Zr)/Si multilayer system VL - 10 IS - 12 SP - 1 EP - 14 DO - 10.3390/nano10122531 ER -
@article{ author = "Petrović, Suzana and Peruško, Davor and Mimidis, Alexandros and Kavatzikidou, Paraskevi and Kovač, Janez and Ranella, Anthi and Novaković, Mirjana M. and Popović, Maja and Stratakis, Emmanuel", year = "2020", abstract = "Ultrafast laser processing with the formation of periodic surface nanostructures on the 15×(Ti/Zr)/Si multilayers is studied in order to the improve cell response. A novel nanocomposite structure in the form of 15x(Ti/Zr)/Si multilayer thin films, with satisfying mechanical properties and moderate biocompatibility, was deposited by ion sputtering on an Si substrate. The multilayer 15×(Ti/Zr)/Si thin films were modified by femtosecond laser pulses in air to induce the following modifications: (i) mixing of components inside of the multilayer structures, (ii) the formation of an ultrathin oxide layer at the surfaces, and (iii) surface nano-texturing with the creation of laser-induced periodic surface structure (LIPSS). The focus of this study was an examination of the novel Ti/Zr multilayer thin films in order to create a surface texture with suitable composition and structure for cell integration. Using the SEM and confocal microscopies of the laser-modified Ti/Zr surfaces with seeded cell culture (NIH 3T3 fibroblasts), it was found that cell adhesion and growth depend on the surface composition and morphological patterns. These results indicated a good proliferation of cells after two and four days with some tendency of the cell orientation along the LIPSSs. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.", journal = "Nanomaterials", title = "Response of NIH 3T3 fibroblast cells on laser-induced periodic surface structures on a 15×(Ti/Zr)/Si multilayer system", volume = "10", number = "12", pages = "1-14", doi = "10.3390/nano10122531" }
Petrović, S., Peruško, D., Mimidis, A., Kavatzikidou, P., Kovač, J., Ranella, A., Novaković, M. M., Popović, M.,& Stratakis, E.. (2020). Response of NIH 3T3 fibroblast cells on laser-induced periodic surface structures on a 15×(Ti/Zr)/Si multilayer system. in Nanomaterials, 10(12), 1-14. https://doi.org/10.3390/nano10122531
Petrović S, Peruško D, Mimidis A, Kavatzikidou P, Kovač J, Ranella A, Novaković MM, Popović M, Stratakis E. Response of NIH 3T3 fibroblast cells on laser-induced periodic surface structures on a 15×(Ti/Zr)/Si multilayer system. in Nanomaterials. 2020;10(12):1-14. doi:10.3390/nano10122531 .
Petrović, Suzana, Peruško, Davor, Mimidis, Alexandros, Kavatzikidou, Paraskevi, Kovač, Janez, Ranella, Anthi, Novaković, Mirjana M., Popović, Maja, Stratakis, Emmanuel, "Response of NIH 3T3 fibroblast cells on laser-induced periodic surface structures on a 15×(Ti/Zr)/Si multilayer system" in Nanomaterials, 10, no. 12 (2020):1-14, https://doi.org/10.3390/nano10122531 . .