Physico-chemical characterization of 90Y-labeled antimony trisulfide colloid and comparison with 99mTc-labeled one
Конференцијски прилог (Објављена верзија)
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Society of Physical Chemists of Serbia
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In radionuclide therapy, the importance of 90Y as a beta-emitting radionuclide is increasing rapidly. The properties of the 90Y-labeled antimony trisulfide colloid (Sb2S3) were compared with the 99mTc-labeled one. Labeling efficiencies reached >96% and >97% for 90Y- and 99mTc-labeled colloids respectively. Both preparations were stable for 72 h in saline and 1% albumin solution. Filtration analysis showed that more than 94% of total 90Y radioactivity is associated with the colloidal particles smaller than 20 nm, while more than 90% of 99mTc radioactivity is associated with the particles retained on the filter with a 20 nm pore size. 90Y-labeled colloids showed high labeling efficiency, stability and potency for clinical use.
Извор:
Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 2008, 2, 462-464Издавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Истраживање механизма интеракција биолошки активних једињења са биомолекулима (RS-MESTD-MPN2006-2010-142051)
Напомена:
- Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 24-28 September 2008
Колекције
Институција/група
VinčaTY - CONF AU - Janković, Drina AU - Đokić, Divna Đ. AU - Nikolić, N. PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9384 AB - In radionuclide therapy, the importance of 90Y as a beta-emitting radionuclide is increasing rapidly. The properties of the 90Y-labeled antimony trisulfide colloid (Sb2S3) were compared with the 99mTc-labeled one. Labeling efficiencies reached >96% and >97% for 90Y- and 99mTc-labeled colloids respectively. Both preparations were stable for 72 h in saline and 1% albumin solution. Filtration analysis showed that more than 94% of total 90Y radioactivity is associated with the colloidal particles smaller than 20 nm, while more than 90% of 99mTc radioactivity is associated with the particles retained on the filter with a 20 nm pore size. 90Y-labeled colloids showed high labeling efficiency, stability and potency for clinical use. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry T1 - Physico-chemical characterization of 90Y-labeled antimony trisulfide colloid and comparison with 99mTc-labeled one VL - 2 SP - 462 EP - 464 UR - https://hdl.handle.net/21.15107/rcub_vinar_9384 ER -
@conference{ author = "Janković, Drina and Đokić, Divna Đ. and Nikolić, N.", year = "2008", abstract = "In radionuclide therapy, the importance of 90Y as a beta-emitting radionuclide is increasing rapidly. The properties of the 90Y-labeled antimony trisulfide colloid (Sb2S3) were compared with the 99mTc-labeled one. Labeling efficiencies reached >96% and >97% for 90Y- and 99mTc-labeled colloids respectively. Both preparations were stable for 72 h in saline and 1% albumin solution. Filtration analysis showed that more than 94% of total 90Y radioactivity is associated with the colloidal particles smaller than 20 nm, while more than 90% of 99mTc radioactivity is associated with the particles retained on the filter with a 20 nm pore size. 90Y-labeled colloids showed high labeling efficiency, stability and potency for clinical use.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry", title = "Physico-chemical characterization of 90Y-labeled antimony trisulfide colloid and comparison with 99mTc-labeled one", volume = "2", pages = "462-464", url = "https://hdl.handle.net/21.15107/rcub_vinar_9384" }
Janković, D., Đokić, D. Đ.,& Nikolić, N.. (2008). Physico-chemical characterization of 90Y-labeled antimony trisulfide colloid and comparison with 99mTc-labeled one. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry Society of Physical Chemists of Serbia., 2, 462-464. https://hdl.handle.net/21.15107/rcub_vinar_9384
Janković D, Đokić DĐ, Nikolić N. Physico-chemical characterization of 90Y-labeled antimony trisulfide colloid and comparison with 99mTc-labeled one. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;2:462-464. https://hdl.handle.net/21.15107/rcub_vinar_9384 .
Janković, Drina, Đokić, Divna Đ., Nikolić, N., "Physico-chemical characterization of 90Y-labeled antimony trisulfide colloid and comparison with 99mTc-labeled one" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 2 (2008):462-464, https://hdl.handle.net/21.15107/rcub_vinar_9384 .