Chronic stress impairment of prefrontal cortex energy metabolism is related to gender and can not be ameliorated by antidepresant fluoxetine
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Society of Physical Chemists of Serbia
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The activity of cytochrome c oxidase correlates with neuronal functional activity
and is considered as an ideal marker for examining the effects of antidepressant
treatment on brain metabolism. We investigated gender specific effects of
antidepressant fluoxetine on cytochrome c oxidase activity in the mitochondria of
prefrontal cortex (PFC) of chronically isolated female and male Wistar rats. Our
results showed that chronic psychosocial isolation (CPSI) increased cytochrome c
oxidase activity in female PFC, while in males, this activity was decreased.
Fluoxetine treatment did not normalize cytochrome c oxidase activity in either
CPSI females or CPSI males. Our data suggest that the pattern of PFC energy
metabolism impairment by CPSI is related to gender, but that fluoxetine treatment
was unable to ameliorate these defects.
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Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2012, 1, 361-363Publisher:
- Society of Physical Chemists of Serbia
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- Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 24-28 September 2012
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VinčaTY - CONF AU - Adžić, Miroslav AU - Simić, Iva AU - Mitić, Miloš AU - Đorđević, Jelena D. AU - Radojčić, Marija PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9283 AB - The activity of cytochrome c oxidase correlates with neuronal functional activity and is considered as an ideal marker for examining the effects of antidepressant treatment on brain metabolism. We investigated gender specific effects of antidepressant fluoxetine on cytochrome c oxidase activity in the mitochondria of prefrontal cortex (PFC) of chronically isolated female and male Wistar rats. Our results showed that chronic psychosocial isolation (CPSI) increased cytochrome c oxidase activity in female PFC, while in males, this activity was decreased. Fluoxetine treatment did not normalize cytochrome c oxidase activity in either CPSI females or CPSI males. Our data suggest that the pattern of PFC energy metabolism impairment by CPSI is related to gender, but that fluoxetine treatment was unable to ameliorate these defects. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry T1 - Chronic stress impairment of prefrontal cortex energy metabolism is related to gender and can not be ameliorated by antidepresant fluoxetine VL - 1 SP - 361 EP - 363 UR - https://hdl.handle.net/21.15107/rcub_vinar_9283 ER -
@conference{ author = "Adžić, Miroslav and Simić, Iva and Mitić, Miloš and Đorđević, Jelena D. and Radojčić, Marija", year = "2012", abstract = "The activity of cytochrome c oxidase correlates with neuronal functional activity and is considered as an ideal marker for examining the effects of antidepressant treatment on brain metabolism. We investigated gender specific effects of antidepressant fluoxetine on cytochrome c oxidase activity in the mitochondria of prefrontal cortex (PFC) of chronically isolated female and male Wistar rats. Our results showed that chronic psychosocial isolation (CPSI) increased cytochrome c oxidase activity in female PFC, while in males, this activity was decreased. Fluoxetine treatment did not normalize cytochrome c oxidase activity in either CPSI females or CPSI males. Our data suggest that the pattern of PFC energy metabolism impairment by CPSI is related to gender, but that fluoxetine treatment was unable to ameliorate these defects.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry", title = "Chronic stress impairment of prefrontal cortex energy metabolism is related to gender and can not be ameliorated by antidepresant fluoxetine", volume = "1", pages = "361-363", url = "https://hdl.handle.net/21.15107/rcub_vinar_9283" }
Adžić, M., Simić, I., Mitić, M., Đorđević, J. D.,& Radojčić, M.. (2012). Chronic stress impairment of prefrontal cortex energy metabolism is related to gender and can not be ameliorated by antidepresant fluoxetine. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry Society of Physical Chemists of Serbia., 1, 361-363. https://hdl.handle.net/21.15107/rcub_vinar_9283
Adžić M, Simić I, Mitić M, Đorđević JD, Radojčić M. Chronic stress impairment of prefrontal cortex energy metabolism is related to gender and can not be ameliorated by antidepresant fluoxetine. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;1:361-363. https://hdl.handle.net/21.15107/rcub_vinar_9283 .
Adžić, Miroslav, Simić, Iva, Mitić, Miloš, Đorđević, Jelena D., Radojčić, Marija, "Chronic stress impairment of prefrontal cortex energy metabolism is related to gender and can not be ameliorated by antidepresant fluoxetine" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 1 (2012):361-363, https://hdl.handle.net/21.15107/rcub_vinar_9283 .