Приказ основних података о документу
Aminosilanized flower-structured superparamagnetic iron oxide nanoparticles coupled to 131I-labeled CC49 antibody for combined radionuclide and hyperthermia therapy of cancer
dc.creator | Stanković, Aljoša | |
dc.creator | Mihailović, Jasna | |
dc.creator | Mirković, Marija D. | |
dc.creator | Radović, Magdalena | |
dc.creator | Milanović, Zorana | |
dc.creator | Ognjanović, Miloš | |
dc.creator | Janković, Drina | |
dc.creator | Antić, Bratislav | |
dc.creator | Mijović, Milica | |
dc.creator | Vranješ-Đurić, Sanja | |
dc.creator | Prijović, Željko | |
dc.date.accessioned | 2021-04-29T11:55:57Z | |
dc.date.available | 2021-04-29T11:55:57Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/9117 | |
dc.description.abstract | Combined radionuclide therapy with magnetic nanoparticles-mediated hyperthermia has been under research focus as a promising tumor therapy approach. The objective of this study was to investigate the potential of 131I-radiolabeled superparamagnetic iron oxide nanoparticles (SPIONs) prepared as the ~40 nm flower-shaped structures with excellent heating efficiency (specific absorption rate at H0 = 15.9 kA∙m−1 and resonant frequency of 252 kHz was 123.1 W∙g−1) for nano-brachytherapy of tumors. 131I-radiolabeled CC49 antibody attached to SPIONs via reactive groups of 3-aminopropyltriethoxysilane (APTES) provided specificity and long-lasting localized retention after their intratumoral application into LS174T human colon adenocarcinoma xenografts in NOD-SCID mice. The results demonstrate feasibility and effectiveness of magnetic hyperthermia (HT), radionuclide therapy (RT) and their combination (HT + RT) in treating cancer in xenograft models. Combined therapy approach induced a significant (p < 0.01) tumor growth suppression in comparison to untreated groups presented by the tumor volume inhibitory rate (TVIR): 54.38%, 68.77%, 73.00% for HT, RT and HT + RT, respectively in comparison to untreated group and 48.31%, 64,62% and 69,41%, respectively, for the SPIONs-only injected group. Histopathology analysis proved the necrosis and apoptosis in treated tumors without general toxicity. Obtained data support the idea that nano-brachytherapy combined with hyperthermia is a promising approach for effective cancer treatment. | en |
dc.language.iso | en | |
dc.relation | Ministry of Education, Science and Technological Development of the Republic of Serbia | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Pharmaceutics | |
dc.subject | Superparamagnetic nanoparticles | en |
dc.subject | Radionuclide (I-131) therapy | en |
dc.subject | Hyperthermia | en |
dc.subject | CC49 monoclonal antibody | en |
dc.subject | Combined therapy | en |
dc.subject | Nano-brachytherapy | en |
dc.subject | Nano-radiopharmaceuticals | en |
dc.title | Aminosilanized flower-structured superparamagnetic iron oxide nanoparticles coupled to 131I-labeled CC49 antibody for combined radionuclide and hyperthermia therapy of cancer | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Мирковић, Марија; Радовић, Магдалена; Милановић, Зорана; Огњановић, Милош; Јанковић, Дрина; Aнтић, Братислав; Мијовић, Милица; Врањеш-Ђурић, Сања; Пријовић, Жељко; Станковић, Aљоша; Михаиловић, Јасна; | |
dc.rights.holder | © 2020 Elsevier B.V. | |
dc.citation.volume | 587 | |
dc.citation.spage | 119628 | |
dc.identifier.wos | 000568785100009 | |
dc.identifier.doi | 10.1016/j.ijpharm.2020.119628 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 32681867 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85088953656 |
Документи
Овај документ се појављује у следећим колекцијама
-
020 - Laboratorija za teorijsku fiziku i fiziku kondenzovane materije
Department of Theoretical Physics and Condensed Matter Physics -
070 - Laboratorija za radioizotope
Department of Radioisotopes -
Radovi istraživača
Researchers' publications