Calcium ions tune the beats of cilia and flagella
Samo za registrovane korisnike
2020
Članak u časopisu (Objavljena verzija)
,
© 2020 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elabora...ted the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating.
Ključne reči:
Microtubule / Axoneme / Nonlinear electric transmission line / Ionic cloudIzvor:
Biosystems, 2020, 196, 104172-Finansiranje / projekti:
- Provincial Secretariat for Higher Education and Scientific Research of AP Vojvodina [1144512708/201603]
- Uticaj elementarnih ekscitacija i konformacija na fizička svojstva novih materijala baziranih na jako korelisanim niskodimenzionalnim sistemima (RS-MESTD-Basic Research (BR or ON)-171009)
- Razvoj metoda, senzora, i sistema za praćenje kvaliteta vode, vazduha i zemljišta (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43008)
- Fotonika mikro i nano strukturnih materijala (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
- Serbian Academy of Sciences and Arts
DOI: 10.1016/j.biosystems.2020.104172
ISSN: 0303-2647
PubMed: 32534169
WoS: 000564562900003
Scopus: 2-s2.0-85086886772
Institucija/grupa
VinčaTY - JOUR AU - Satarić, Miljko V. AU - Nemeš, Tomas AU - Satarić, Bogdan AU - Sekulić, Dalibor AU - Zdravković, Slobodan PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9059 AB - The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elaborated the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating. T2 - Biosystems T1 - Calcium ions tune the beats of cilia and flagella VL - 196 SP - 104172 DO - 10.1016/j.biosystems.2020.104172 ER -
@article{ author = "Satarić, Miljko V. and Nemeš, Tomas and Satarić, Bogdan and Sekulić, Dalibor and Zdravković, Slobodan", year = "2020", abstract = "The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elaborated the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating.", journal = "Biosystems", title = "Calcium ions tune the beats of cilia and flagella", volume = "196", pages = "104172", doi = "10.1016/j.biosystems.2020.104172" }
Satarić, M. V., Nemeš, T., Satarić, B., Sekulić, D.,& Zdravković, S.. (2020). Calcium ions tune the beats of cilia and flagella. in Biosystems, 196, 104172. https://doi.org/10.1016/j.biosystems.2020.104172
Satarić MV, Nemeš T, Satarić B, Sekulić D, Zdravković S. Calcium ions tune the beats of cilia and flagella. in Biosystems. 2020;196:104172. doi:10.1016/j.biosystems.2020.104172 .
Satarić, Miljko V., Nemeš, Tomas, Satarić, Bogdan, Sekulić, Dalibor, Zdravković, Slobodan, "Calcium ions tune the beats of cilia and flagella" in Biosystems, 196 (2020):104172, https://doi.org/10.1016/j.biosystems.2020.104172 . .