Calcium ions tune the beats of cilia and flagella
Само за регистроване кориснике
2020
Чланак у часопису (Објављена верзија)
,
© 2020 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт
The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elabora...ted the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating.
Кључне речи:
Microtubule / Axoneme / Nonlinear electric transmission line / Ionic cloudИзвор:
Biosystems, 2020, 196, 104172-Финансирање / пројекти:
- Provincial Secretariat for Higher Education and Scientific Research of AP Vojvodina [1144512708/201603]
- Утицај елементарних ексцитација и конформација на физичка својства нових материјала базираних на јако корелисаним нискодимензионалним системима (RS-MESTD-Basic Research (BR or ON)-171009)
- Развој метода, сензора, и система за праћење квалитета воде, ваздуха и земљишта (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43008)
- Фотоника микро и нано структурних материјала (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
- Serbian Academy of Sciences and Arts
DOI: 10.1016/j.biosystems.2020.104172
ISSN: 0303-2647
PubMed: 32534169
WoS: 000564562900003
Scopus: 2-s2.0-85086886772
Институција/група
VinčaTY - JOUR AU - Satarić, Miljko V. AU - Nemeš, Tomas AU - Satarić, Bogdan AU - Sekulić, Dalibor AU - Zdravković, Slobodan PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9059 AB - The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elaborated the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating. T2 - Biosystems T1 - Calcium ions tune the beats of cilia and flagella VL - 196 SP - 104172 DO - 10.1016/j.biosystems.2020.104172 ER -
@article{ author = "Satarić, Miljko V. and Nemeš, Tomas and Satarić, Bogdan and Sekulić, Dalibor and Zdravković, Slobodan", year = "2020", abstract = "The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elaborated the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating.", journal = "Biosystems", title = "Calcium ions tune the beats of cilia and flagella", volume = "196", pages = "104172", doi = "10.1016/j.biosystems.2020.104172" }
Satarić, M. V., Nemeš, T., Satarić, B., Sekulić, D.,& Zdravković, S.. (2020). Calcium ions tune the beats of cilia and flagella. in Biosystems, 196, 104172. https://doi.org/10.1016/j.biosystems.2020.104172
Satarić MV, Nemeš T, Satarić B, Sekulić D, Zdravković S. Calcium ions tune the beats of cilia and flagella. in Biosystems. 2020;196:104172. doi:10.1016/j.biosystems.2020.104172 .
Satarić, Miljko V., Nemeš, Tomas, Satarić, Bogdan, Sekulić, Dalibor, Zdravković, Slobodan, "Calcium ions tune the beats of cilia and flagella" in Biosystems, 196 (2020):104172, https://doi.org/10.1016/j.biosystems.2020.104172 . .