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Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer
dc.creator | Matijević, Milica | |
dc.creator | Nakarada, Đura | |
dc.creator | Liang, Xinyue | |
dc.creator | Korićanac, Lela | |
dc.creator | Rajsiglova, Lenka | |
dc.creator | Vannucci, Luca | |
dc.creator | Nešić, Maja D. | |
dc.creator | Vranješ, Mila | |
dc.creator | Mojović, Miloš D. | |
dc.creator | Mi, Lan | |
dc.creator | Estrela-Lopis, Irina | |
dc.creator | Böttner, Julia | |
dc.creator | Šaponjić, Zoran | |
dc.creator | Petković, Marijana | |
dc.creator | Stepić, Milutin | |
dc.date.accessioned | 2021-04-05T09:52:44Z | |
dc.date.available | 2021-04-05T09:52:44Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1388-0764 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/9058 | |
dc.description.abstract | TiO2 prolatenanospheroids (PNSs) may be photosensitizers (PSs), which act by catalyzation of hydroxyl radical (∙OH) formation upon light illumination. ∙OH might, in turn, contribute to killing of cancer cells. On the other hand, there is great concern about toxicity in the dark of TiO2 nanoparticles in general. In this work, we have investigated the biocompatibility of TiO2 PNSs of the anatase crystal form (length between 100 and 300 nm and width 50 nm) in the dark with immune cells and light-induced cytotoxicity on several cancer cell lines. The effects of the treatment of different cell lines with several concentrations of TiO2 PNSs suspensions showed the specifics of cells’ viability and the intracellular localization. The results of in vitro studies obtained by cytotoxicity assays adjusted to individual cell lines’ metabolism point towards the biocompatibility of TiO2 PNSs at low and moderate concentrations in the dark, which neither kill the cells, nor induce activation of the immune system cells. Laser scanning confocal microscopy revealed that PNSs are taken up by cells, and insight into the intracellular distribution was obtained in this study. | en |
dc.language.iso | en | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172011/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172056/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45010/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41005/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS// | |
dc.relation | Danube Region Strategies multilateral project -Danube meets Omics [DS 052] | |
dc.relation | Bilateral project Republic of Serbia-People's Republic of China [451-00-478/2018-09/16] | |
dc.rights | restrictedAccess | |
dc.source | Journal of Nanoparticle Research | |
dc.subject | TiO(2)prolate nanospheroids | en |
dc.subject | Photodynamic therapy | en |
dc.subject | Cancer therapy | en |
dc.subject | Oxidative activity | en |
dc.subject | Nanomedicine | en |
dc.title | Biocompatibility of TiO2 prolate nanospheroids as a potential photosenzitizer in therapy of cancer | |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Ми, Лан; Естрела-Лопис, Ирина; Бöттнер, Јулиа; Лианг, Xинyуе; Матијевић, Милица; Корићанац, Лела; Врањеш, Мила; Шапоњић, Зоран; Петковић, Маријана; Степић, Милутин; Накарада, Ђура; Рајсиглова, Ленка; Ваннуцци, Луца; Нешић, Маја Д.; Мојовић, Милош Д.; | |
dc.rights.holder | © 2020, Springer Nature B.V. | |
dc.citation.volume | 22 | |
dc.citation.issue | 7 | |
dc.citation.spage | 175 | |
dc.identifier.wos | 000547506100001 | |
dc.identifier.doi | 10.1007/s11051-020-04899-3 | |
dc.citation.rank | M23 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85087054250 |
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030 - Laboratorija za radijacionu hemiju i fiziku
Department of Radiation Chemistry and Physics -
040 - Laboratorija za atomsku fiziku
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090 - Laboratorija za molekularnu biologiju i endokrinologiju
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