Estradiol induces synaptic rearrangements
Abstract
17β-Estradiol (E2) is a potent steroid hormone of both gonadal and neuronal origin that exerts profound effects on neuroplasticity in several brain regions. Dendritic spine and synapse formation and rearrangements are modulated and mediated by estrogens. In this chapter, we highlighted the essential background concerning the effects of E2 on synaptic rearrangements accompanied by synaptic plasticity in E2-sensitive brain regions that mediate learning and memory, i.e., cortex and hippocampus. We also address details of the molecular mechanisms underlying E2 regulation of spine dynamics. The proposed models of action of E2 overlaps with that for well-established synaptic modulators, such as adenosine. Thus, the possible synergistic effects of those two molecules in respect to synaptic rearrangement and plasticity were presented.
Source:
Vitamins and Hormones, 2020, 114, 233-256Funding / projects:
- Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-MESTD-Basic Research (BR or ON)-173044)
- Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
Note:
- Volume 114: Hormones and Synapse
DOI: 10.1016/bs.vh.2020.04.006
ISBN: 9780128220252
ISSN: 0083-6729
PubMed: 32723546
WoS: 000612641100011
Scopus: 2-s2.0-85086668402
Institution/Community
VinčaTY - CHAP AU - Grković, Ivana AU - Mitrović, Nataša Lj. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9056 AB - 17β-Estradiol (E2) is a potent steroid hormone of both gonadal and neuronal origin that exerts profound effects on neuroplasticity in several brain regions. Dendritic spine and synapse formation and rearrangements are modulated and mediated by estrogens. In this chapter, we highlighted the essential background concerning the effects of E2 on synaptic rearrangements accompanied by synaptic plasticity in E2-sensitive brain regions that mediate learning and memory, i.e., cortex and hippocampus. We also address details of the molecular mechanisms underlying E2 regulation of spine dynamics. The proposed models of action of E2 overlaps with that for well-established synaptic modulators, such as adenosine. Thus, the possible synergistic effects of those two molecules in respect to synaptic rearrangement and plasticity were presented. T2 - Vitamins and Hormones T1 - Estradiol induces synaptic rearrangements VL - 114 SP - 233 EP - 256 DO - 10.1016/bs.vh.2020.04.006 ER -
@inbook{ author = "Grković, Ivana and Mitrović, Nataša Lj.", year = "2020", abstract = "17β-Estradiol (E2) is a potent steroid hormone of both gonadal and neuronal origin that exerts profound effects on neuroplasticity in several brain regions. Dendritic spine and synapse formation and rearrangements are modulated and mediated by estrogens. In this chapter, we highlighted the essential background concerning the effects of E2 on synaptic rearrangements accompanied by synaptic plasticity in E2-sensitive brain regions that mediate learning and memory, i.e., cortex and hippocampus. We also address details of the molecular mechanisms underlying E2 regulation of spine dynamics. The proposed models of action of E2 overlaps with that for well-established synaptic modulators, such as adenosine. Thus, the possible synergistic effects of those two molecules in respect to synaptic rearrangement and plasticity were presented.", journal = "Vitamins and Hormones", booktitle = "Estradiol induces synaptic rearrangements", volume = "114", pages = "233-256", doi = "10.1016/bs.vh.2020.04.006" }
Grković, I.,& Mitrović, N. Lj.. (2020). Estradiol induces synaptic rearrangements. in Vitamins and Hormones, 114, 233-256. https://doi.org/10.1016/bs.vh.2020.04.006
Grković I, Mitrović NL. Estradiol induces synaptic rearrangements. in Vitamins and Hormones. 2020;114:233-256. doi:10.1016/bs.vh.2020.04.006 .
Grković, Ivana, Mitrović, Nataša Lj., "Estradiol induces synaptic rearrangements" in Vitamins and Hormones, 114 (2020):233-256, https://doi.org/10.1016/bs.vh.2020.04.006 . .