Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery
Samo za registrovane korisnike
2016
Autori
Nešić, MajaPopović, Iva A.
Leskovac, Andreja
Šaponjić, Zoran
Radoičić, Marija B.
Stepić, Milutin
Petković, Marijana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Photo-responsive drug release systems are promising for drug delivery applications due to many benefits compared to conventional chemotherapy such as targeted, controlled release of a drug and reduced toxicity to healthy tissues. In this work, we report synthesis of the nanocomposite system based on carrier TiO2 nanoparticles and potential anticancer ruthenium complex, with light controllable release properties. Nanocomposite system showed biological activity and induced the generation of free radicals, which are implied in the efficient cell killing. The drug release tests demonstrated sustained release of the transition metal complex from the surface implying the potency for the controlled drug delivery system. Taking into account photoactivity of the Ru-complex, in the next step we have investigated the influence of green light on the rate of the complex release, and the results showed dependence of the Ru-complex release from the surface of TiO2 nanoparticles on the applied laser e...nergy. Therefore, these characteristics make this nanocomposite system promising for the photo-responsive chemotherapy.
Ključne reči:
Photo-responsive release / Nanocomposite system / Anticancer drugIzvor:
Optical and Quantum Electronics, 2016, 48, 2Izdavač:
- Springer
Finansiranje / projekti:
- Ispitivanje mehanizma reakcija kompleksa jona prelaznih metala sa biološki značajnim molekulima (RS-MESTD-Basic Research (BR or ON)-172011)
- Uticaj veličine, oblika i strukture nanočestica na njihova svojstva i svojstva nanokompozita (RS-MESTD-Basic Research (BR or ON)-172056)
- Fotonika mikro i nano strukturnih materijala (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
DOI: 10.1007/s11082-016-0421-5
ISSN: 0306-8919; 1572-817X
WoS: 000368741200043
Scopus: 2-s2.0-84955298928
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Nešić, Maja AU - Popović, Iva A. AU - Leskovac, Andreja AU - Šaponjić, Zoran AU - Radoičić, Marija B. AU - Stepić, Milutin AU - Petković, Marijana PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/904 AB - Photo-responsive drug release systems are promising for drug delivery applications due to many benefits compared to conventional chemotherapy such as targeted, controlled release of a drug and reduced toxicity to healthy tissues. In this work, we report synthesis of the nanocomposite system based on carrier TiO2 nanoparticles and potential anticancer ruthenium complex, with light controllable release properties. Nanocomposite system showed biological activity and induced the generation of free radicals, which are implied in the efficient cell killing. The drug release tests demonstrated sustained release of the transition metal complex from the surface implying the potency for the controlled drug delivery system. Taking into account photoactivity of the Ru-complex, in the next step we have investigated the influence of green light on the rate of the complex release, and the results showed dependence of the Ru-complex release from the surface of TiO2 nanoparticles on the applied laser energy. Therefore, these characteristics make this nanocomposite system promising for the photo-responsive chemotherapy. PB - Springer T2 - Optical and Quantum Electronics T1 - Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery VL - 48 IS - 2 DO - 10.1007/s11082-016-0421-5 ER -
@article{ author = "Nešić, Maja and Popović, Iva A. and Leskovac, Andreja and Šaponjić, Zoran and Radoičić, Marija B. and Stepić, Milutin and Petković, Marijana", year = "2016", abstract = "Photo-responsive drug release systems are promising for drug delivery applications due to many benefits compared to conventional chemotherapy such as targeted, controlled release of a drug and reduced toxicity to healthy tissues. In this work, we report synthesis of the nanocomposite system based on carrier TiO2 nanoparticles and potential anticancer ruthenium complex, with light controllable release properties. Nanocomposite system showed biological activity and induced the generation of free radicals, which are implied in the efficient cell killing. The drug release tests demonstrated sustained release of the transition metal complex from the surface implying the potency for the controlled drug delivery system. Taking into account photoactivity of the Ru-complex, in the next step we have investigated the influence of green light on the rate of the complex release, and the results showed dependence of the Ru-complex release from the surface of TiO2 nanoparticles on the applied laser energy. Therefore, these characteristics make this nanocomposite system promising for the photo-responsive chemotherapy.", publisher = "Springer", journal = "Optical and Quantum Electronics", title = "Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery", volume = "48", number = "2", doi = "10.1007/s11082-016-0421-5" }
Nešić, M., Popović, I. A., Leskovac, A., Šaponjić, Z., Radoičić, M. B., Stepić, M.,& Petković, M.. (2016). Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery. in Optical and Quantum Electronics Springer., 48(2). https://doi.org/10.1007/s11082-016-0421-5
Nešić M, Popović IA, Leskovac A, Šaponjić Z, Radoičić MB, Stepić M, Petković M. Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery. in Optical and Quantum Electronics. 2016;48(2). doi:10.1007/s11082-016-0421-5 .
Nešić, Maja, Popović, Iva A., Leskovac, Andreja, Šaponjić, Zoran, Radoičić, Marija B., Stepić, Milutin, Petković, Marijana, "Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery" in Optical and Quantum Electronics, 48, no. 2 (2016), https://doi.org/10.1007/s11082-016-0421-5 . .