Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery
Authorized Users Only
2016
Authors
Nešić, MajaPopović, Iva A.
Leskovac, Andreja
Šaponjić, Zoran
Radoičić, Marija B.
Stepić, Milutin
Petković, Marijana
Article (Published version)
Metadata
Show full item recordAbstract
Photo-responsive drug release systems are promising for drug delivery applications due to many benefits compared to conventional chemotherapy such as targeted, controlled release of a drug and reduced toxicity to healthy tissues. In this work, we report synthesis of the nanocomposite system based on carrier TiO2 nanoparticles and potential anticancer ruthenium complex, with light controllable release properties. Nanocomposite system showed biological activity and induced the generation of free radicals, which are implied in the efficient cell killing. The drug release tests demonstrated sustained release of the transition metal complex from the surface implying the potency for the controlled drug delivery system. Taking into account photoactivity of the Ru-complex, in the next step we have investigated the influence of green light on the rate of the complex release, and the results showed dependence of the Ru-complex release from the surface of TiO2 nanoparticles on the applied laser e...nergy. Therefore, these characteristics make this nanocomposite system promising for the photo-responsive chemotherapy.
Keywords:
Photo-responsive release / Nanocomposite system / Anticancer drugSource:
Optical and Quantum Electronics, 2016, 48, 2Publisher:
- Springer
Funding / projects:
- Mechanistic studies of the reactions of transition metal ion complexes with biologically relevant molecules (RS-MESTD-Basic Research (BR or ON)-172011)
- Size-, shape- and structure- dependent properties of nanoparticles and nanocomposites (RS-MESTD-Basic Research (BR or ON)-172056)
- Photonics of micro and nano structured materials (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
DOI: 10.1007/s11082-016-0421-5
ISSN: 0306-8919; 1572-817X
WoS: 000368741200043
Scopus: 2-s2.0-84955298928
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Institution/Community
VinčaTY - JOUR AU - Nešić, Maja AU - Popović, Iva A. AU - Leskovac, Andreja AU - Šaponjić, Zoran AU - Radoičić, Marija B. AU - Stepić, Milutin AU - Petković, Marijana PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/904 AB - Photo-responsive drug release systems are promising for drug delivery applications due to many benefits compared to conventional chemotherapy such as targeted, controlled release of a drug and reduced toxicity to healthy tissues. In this work, we report synthesis of the nanocomposite system based on carrier TiO2 nanoparticles and potential anticancer ruthenium complex, with light controllable release properties. Nanocomposite system showed biological activity and induced the generation of free radicals, which are implied in the efficient cell killing. The drug release tests demonstrated sustained release of the transition metal complex from the surface implying the potency for the controlled drug delivery system. Taking into account photoactivity of the Ru-complex, in the next step we have investigated the influence of green light on the rate of the complex release, and the results showed dependence of the Ru-complex release from the surface of TiO2 nanoparticles on the applied laser energy. Therefore, these characteristics make this nanocomposite system promising for the photo-responsive chemotherapy. PB - Springer T2 - Optical and Quantum Electronics T1 - Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery VL - 48 IS - 2 DO - 10.1007/s11082-016-0421-5 ER -
@article{ author = "Nešić, Maja and Popović, Iva A. and Leskovac, Andreja and Šaponjić, Zoran and Radoičić, Marija B. and Stepić, Milutin and Petković, Marijana", year = "2016", abstract = "Photo-responsive drug release systems are promising for drug delivery applications due to many benefits compared to conventional chemotherapy such as targeted, controlled release of a drug and reduced toxicity to healthy tissues. In this work, we report synthesis of the nanocomposite system based on carrier TiO2 nanoparticles and potential anticancer ruthenium complex, with light controllable release properties. Nanocomposite system showed biological activity and induced the generation of free radicals, which are implied in the efficient cell killing. The drug release tests demonstrated sustained release of the transition metal complex from the surface implying the potency for the controlled drug delivery system. Taking into account photoactivity of the Ru-complex, in the next step we have investigated the influence of green light on the rate of the complex release, and the results showed dependence of the Ru-complex release from the surface of TiO2 nanoparticles on the applied laser energy. Therefore, these characteristics make this nanocomposite system promising for the photo-responsive chemotherapy.", publisher = "Springer", journal = "Optical and Quantum Electronics", title = "Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery", volume = "48", number = "2", doi = "10.1007/s11082-016-0421-5" }
Nešić, M., Popović, I. A., Leskovac, A., Šaponjić, Z., Radoičić, M. B., Stepić, M.,& Petković, M.. (2016). Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery. in Optical and Quantum Electronics Springer., 48(2). https://doi.org/10.1007/s11082-016-0421-5
Nešić M, Popović IA, Leskovac A, Šaponjić Z, Radoičić MB, Stepić M, Petković M. Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery. in Optical and Quantum Electronics. 2016;48(2). doi:10.1007/s11082-016-0421-5 .
Nešić, Maja, Popović, Iva A., Leskovac, Andreja, Šaponjić, Zoran, Radoičić, Marija B., Stepić, Milutin, Petković, Marijana, "Testing the photo-sensitive nanocomposite system for potential controlled metallo-drug delivery" in Optical and Quantum Electronics, 48, no. 2 (2016), https://doi.org/10.1007/s11082-016-0421-5 . .