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Sex-specific role of hippocampal NMDA-Erk-mTOR signaling in fear extinction of adolescent mice
(Brain Research Bulletin, 2023)
Adolescence is a key phase of development for perturbations in fear extinction, with inability to adequately manage fear a potent factor for developing psychiatric disorders in adulthood. However, while behavioral correlates ...
Mitochondrial signaling in inflammation-induced depressive behavior in female and male rats: The role of glucocorticoid receptor
(Brain Research Bulletin, 2019)
Mitochondrial dysfunction can result from the interplay between elevated inflammatory markers and alterations in hypothalamic–pituitary–adrenal (HPA) axis, and can contribute to pathogenesis of major depression. Therefore, ...
Fluoxetine modulates neuronal activity in stress-related limbic areas of adult rats subjected to the chronic social isolation
(Brain Research Bulletin, 2020)
Antidepressant fluoxetine (Flx) is the first therapeutic choice for the treatment of major depression (MD), however neuroanatomical spots of its action remain unclear. Immunohistochemical detection of c-Fos protein expression ...