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Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression
(Behavioural Brain Research, 2019)
Recent reports have demonstrated that lipopolysaccharide (LPS)-induced depressive-like behaviour is mediated via NMDA receptor. In this study, we further investigated the role of GluN2 A subunit of NMDA receptor in synaptic ...
Povezanost fosforilacionog statusa glukokortikoidnog receptora i ponašanja pacova oba pola u neuroinflamatornom modelu depresije
(Универзитет у Београду, Биолошки факултет, 2019)
Medijatori inflamacije imaju značajnu ulogu u patogenezi depresije. Jedan od načina na koje inflamacija utiče na nastanak ovog oboljenja jeste putem uticaja na hipotalamo-hipofizno-nadbubrežnu (HPA) osu i krajnje produkate ...
Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states
(Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019)
Childhood trauma (CT) increases the risk for psychopathology through disturbed acquisition and extinction of fear. The effects of CT are mediated by abnormalities of the hypothalamic-pituitary-adrenal axis and glucocorticoid ...
Male-specific effects of lipopolysaccharide on glucocorticoid receptor nuclear translocation in the prefrontal cortex of depressive rats
(Psychopharmacology, 2016)
Inflammation plays a key role in the pathogenesis of major depressive disorder (MDD) for a subset of depressed individuals. One of the possible routes by which cytokines can induce depressive symptoms is by promoting the ...
Convergence of glycogen synthase kinase 3 beta and GR signaling in response to fluoxetine treatment in chronically stressed female and male rats
(Behavioural Brain Research, 2017)
Accumulating evidence strongly suggest that impaired glucocorticoid receptor (GR) signaling is involved in stress-related mood disorders, and nominate GR as a potential target for antidepressants (ADs). It is known that ...
Distinct modifications of hippocampal glucocorticoid receptor phosphorylation and FKBPs by lipopolysaccharide in depressive female and male rats
(Journal of Psychopharmacology, 2017)
Inflammation plays a critical role in pathogenesis of depression and can affect the hypothalamic-pituitary-adrenal axis activity. Accordingly, in this study we investigated the role of hippocampal glucocorticoid receptor ...
The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol
(Archives of Biological Sciences, 2018)
We studied the effects of whey and pumpkin seed oil supplementation on the biochemical parameters in blood serum of male rats after chronic ad libitum alcohol consumption. The levels of AST, ALT, total bilirubin, ALP, LDH, ...
Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice
(Journal of Neuroscience Research, 2022)
Adolescent stress predisposes individuals to increased risk for anxiety and depression in adulthood. The stress response is mediated by the glucocorticoid receptor (GR) via regulation of GR-responsive genes involved in ...
Mitochondrial signaling in inflammation-induced depressive behavior in female and male rats: The role of glucocorticoid receptor
(Brain Research Bulletin, 2019)
Mitochondrial dysfunction can result from the interplay between elevated inflammatory markers and alterations in hypothalamic–pituitary–adrenal (HPA) axis, and can contribute to pathogenesis of major depression. Therefore, ...
GluN2A-ERK-mTOR pathway confers a vulnerability to LPS-induced depressive-like behaviour
(Behavioural Brain Research, 2022)
Inflammation plays a key role in the pathogenesis of the major depressive disorder. Namely, neuroinflammation can induce the production of neuroactive metabolites that interfere with N-methyl-D-aspartate receptors ...