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Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models
(Physiological Research, 2006)
The study deals with activity of three antioxidant enzymes, copper, zinc-superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), catalase (CAT) in hippocampus of rats, following the exposure to single chronic ...
Radiobiological analysis of human melanoma cells on the 62 MeV CATANA proton beam
(International Journal of Radiation Biology, 2006)
Purpose: To measure the ability of protons and gamma-rays to effect cell viability and cell survival of human HTB140 melanoma cells. Materials and methods: Exponentially growing HTB140 cells were irradiated close to the ...
Modulation of Antioxidant Enzyme Activities by Sexual Steroid Hormones
(Physiological Research, 2008)
Taking into consideration the biological importance of interaction between antioxidant defense (AD) enzymes and sexual steroid hormones it was deemed important to compare our recent achievements in the field with the state ...
Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine
(Life SciencesLife SciencesLife Sciences, 2023)
Major depressive disorder (MDD) afflicts approximately 5 % of the world population, and about 30–50 % of patients who receive classical antidepressant medications do not achieve complete remission (treatment resistant ...
From chronic stress and anxiety to neurodegeneration: Focus on neuromodulation of the axon initial segment
(Handbook of Clinical Neurology, 2022)
To adapt to the sustained demands of chronic stress, discrete brain circuits undergo structural and functional changes often resulting in anxiety disorders. In some individuals, anxiety disorders precede the development ...
Glucocorticoid receptor and Tryptophan oxygenase activity in streptozotocin treated rats.
(FASEB Journal, 1997)
The goal of this study was to examine the possible effects of the insulin on the functional properties of the glucocorticoid receptor (GR), in the rat liver, as well as its equilibrium binding constant (Kd) and number of ...
The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls
(Psychoneuroendocrinology, 2021)
Hypothalamic–pituitary–adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found ...
Fluoxetine Signature on Hippocampal MAPK Signalling in Sex-Dependent Manner
(Journal of Molecular Neuroscience, 2015)
A growing body of evidence indicates that mitogen-activated protein kinase (MAPK) participates in various stress-induced responses and is considered to be one of the pathophysiological mechanisms in depression. Surprisingly, ...
Geant4-DNA simulation of human cancer cells irradiation with helium ion beams
(Physica Medica, 2023)
Purpose: This study aimed to develop a computational environment for the accurate simulation of human cancer cell irradiation using Geant4-DNA. New cell geometrical models were developed and irradiated by alpha particle ...
Constraints on Yukawa gravity parameters from observations of bright stars
(Journal of Cosmology and Astroparticle Physics, 2023)
In this paper we investigate a Yukawa gravity modification of the Newtonian gravitational potential in a weak field approximation. For that purpose we derived the corresponding equations of motion and used them to perform ...