Претраживање
Приказ резултата 31-40 од 121
The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice
(Journal of Functional Foods, 2022)
The recommended fish oil (FO) supplementation doses often yield low omega-3 polyunsaturated fatty acids (PUFAs) tissue bioavailability, and higher doses (up to 10 g per day) have been increasingly recommended. However, the ...
Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats
(Experientia, 1996)
The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates ...
17 beta-Estradiol in vitro affects Na-dependent and depolarization-induced Ca2+ transport in rat brain synaptosomes
(Experientia, 1996)
Effects of 17 beta-estradiol (E(2)) in vitro on Na-dependent Ca2+ efflux from, and depolarization-induced Ca2+ uptake into, the nerve cell were studied with the use of synaptosomes isolated from the brain stem, mesencephalic ...
Prolonged Alprazolam Treatment Alters Components of Glutamatergic Neurotransmission in the Hippocampus of Male Wistar Rats—The Neuroadaptive Changes following Long-Term Benzodiazepine (Mis)Use
(Pharmaceuticals, 2023)
Alprazolam (ALP), a benzodiazepine (BDZ) used to treat anxiety, panic, and sleep disorders, is one of the most prescribed psychotropic drugs worldwide. The side effects associated with long-term (mis)use of ALP have become ...
Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression
(Behavioural Brain Research, 2019)
Recent reports have demonstrated that lipopolysaccharide (LPS)-induced depressive-like behaviour is mediated via NMDA receptor. In this study, we further investigated the role of GluN2 A subunit of NMDA receptor in synaptic ...
Povezanost fosforilacionog statusa glukokortikoidnog receptora i ponašanja pacova oba pola u neuroinflamatornom modelu depresije
(Универзитет у Београду, Биолошки факултет, 2019)
Medijatori inflamacije imaju značajnu ulogu u patogenezi depresije. Jedan od načina na koje inflamacija utiče na nastanak ovog oboljenja jeste putem uticaja na hipotalamo-hipofizno-nadbubrežnu (HPA) osu i krajnje produkate ...
Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states
(Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019)
Childhood trauma (CT) increases the risk for psychopathology through disturbed acquisition and extinction of fear. The effects of CT are mediated by abnormalities of the hypothalamic-pituitary-adrenal axis and glucocorticoid ...
Male-specific effects of lipopolysaccharide on glucocorticoid receptor nuclear translocation in the prefrontal cortex of depressive rats
(Psychopharmacology, 2016)
Inflammation plays a key role in the pathogenesis of major depressive disorder (MDD) for a subset of depressed individuals. One of the possible routes by which cytokines can induce depressive symptoms is by promoting the ...
Convergence of glycogen synthase kinase 3 beta and GR signaling in response to fluoxetine treatment in chronically stressed female and male rats
(Behavioural Brain Research, 2017)
Accumulating evidence strongly suggest that impaired glucocorticoid receptor (GR) signaling is involved in stress-related mood disorders, and nominate GR as a potential target for antidepressants (ADs). It is known that ...
Distinct modifications of hippocampal glucocorticoid receptor phosphorylation and FKBPs by lipopolysaccharide in depressive female and male rats
(Journal of Psychopharmacology, 2017)
Inflammation plays a critical role in pathogenesis of depression and can affect the hypothalamic-pituitary-adrenal axis activity. Accordingly, in this study we investigated the role of hippocampal glucocorticoid receptor ...