Sleep-related brain activation does not increase the permeability of the blood–brain barrier to glucose
Authors
Silvani, AlessandroAsti, Valentina
Berteotti, Chiara
Bojić, Tijana
Cianci, Tullia
Ferrari, Vera
Franzini, Carlo
Lenzi, Pierluigi
Zoccoli, Giovanna
Article (Published version)
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© 2005 ISCBFM
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We compared blood-brain barrier (BBB) permeability to glucose between quiet wakefulness and rapid-eye-movement (REM) sleep to assess whether changes in BBB permeability play a role in coupling glucose supply to the physiologic metabolic needs of the brain. Male Sprague-Dawley rats were prepared with electrodes for wake-sleep state scoring and with arterial and venous catheters. Using the single-pass, dual-label indicator method, unidirectional glucose extraction by the brain and cerebral blood flow (CBF) were simultaneously measured during states of quiet wakefulness ( n = 12) or REM sleep ( n = 7). The product of BBB surface area and permeability to glucose (PS product) was computed in each state. During REM sleep, CBF significantly exceeded that during quiet wakefulness in all regions but the cerebellum, whereas the difference in the PS product between quiet wakefulness and REM sleep was not statistically significant in any brain region. In the brain as a whole, CBF significantly inc...reased 29% from quiet wakefulness to REM sleep, while a nonsignificant 0.8% increase occurred in the PS product. During REM sleep, the increase in CBF indicates a higher rate of brain glucose consumption than in quiet wakefulness, given the tight flow-metabolism coupling in the brain. Therefore, these data show that modulation of BBB permeability to glucose is not a mechanism that provides ‘energy on demand’ during the physiologic brain activation characterising REM sleep.
Keywords:
blood-brain barrier / cerebral blood flow / glucose / rat / sleepSource:
Journal of Cerebral Blood Flow & Metabolism, 2005, 25, 8, 990-997
DOI: 10.1038/sj.jcbfm.9600100
ISSN: 0271-678X
PubMed: 15758946
WoS: 000230877600006
Scopus: 2-s2.0-23044469858
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VinčaTY - JOUR AU - Silvani, Alessandro AU - Asti, Valentina AU - Berteotti, Chiara AU - Bojić, Tijana AU - Cianci, Tullia AU - Ferrari, Vera AU - Franzini, Carlo AU - Lenzi, Pierluigi AU - Zoccoli, Giovanna PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8872 AB - We compared blood-brain barrier (BBB) permeability to glucose between quiet wakefulness and rapid-eye-movement (REM) sleep to assess whether changes in BBB permeability play a role in coupling glucose supply to the physiologic metabolic needs of the brain. Male Sprague-Dawley rats were prepared with electrodes for wake-sleep state scoring and with arterial and venous catheters. Using the single-pass, dual-label indicator method, unidirectional glucose extraction by the brain and cerebral blood flow (CBF) were simultaneously measured during states of quiet wakefulness ( n = 12) or REM sleep ( n = 7). The product of BBB surface area and permeability to glucose (PS product) was computed in each state. During REM sleep, CBF significantly exceeded that during quiet wakefulness in all regions but the cerebellum, whereas the difference in the PS product between quiet wakefulness and REM sleep was not statistically significant in any brain region. In the brain as a whole, CBF significantly increased 29% from quiet wakefulness to REM sleep, while a nonsignificant 0.8% increase occurred in the PS product. During REM sleep, the increase in CBF indicates a higher rate of brain glucose consumption than in quiet wakefulness, given the tight flow-metabolism coupling in the brain. Therefore, these data show that modulation of BBB permeability to glucose is not a mechanism that provides ‘energy on demand’ during the physiologic brain activation characterising REM sleep. T2 - Journal of Cerebral Blood Flow & Metabolism T1 - Sleep-related brain activation does not increase the permeability of the blood–brain barrier to glucose VL - 25 IS - 8 SP - 990 EP - 997 DO - 10.1038/sj.jcbfm.9600100 ER -
@article{ author = "Silvani, Alessandro and Asti, Valentina and Berteotti, Chiara and Bojić, Tijana and Cianci, Tullia and Ferrari, Vera and Franzini, Carlo and Lenzi, Pierluigi and Zoccoli, Giovanna", year = "2005", abstract = "We compared blood-brain barrier (BBB) permeability to glucose between quiet wakefulness and rapid-eye-movement (REM) sleep to assess whether changes in BBB permeability play a role in coupling glucose supply to the physiologic metabolic needs of the brain. Male Sprague-Dawley rats were prepared with electrodes for wake-sleep state scoring and with arterial and venous catheters. Using the single-pass, dual-label indicator method, unidirectional glucose extraction by the brain and cerebral blood flow (CBF) were simultaneously measured during states of quiet wakefulness ( n = 12) or REM sleep ( n = 7). The product of BBB surface area and permeability to glucose (PS product) was computed in each state. During REM sleep, CBF significantly exceeded that during quiet wakefulness in all regions but the cerebellum, whereas the difference in the PS product between quiet wakefulness and REM sleep was not statistically significant in any brain region. In the brain as a whole, CBF significantly increased 29% from quiet wakefulness to REM sleep, while a nonsignificant 0.8% increase occurred in the PS product. During REM sleep, the increase in CBF indicates a higher rate of brain glucose consumption than in quiet wakefulness, given the tight flow-metabolism coupling in the brain. Therefore, these data show that modulation of BBB permeability to glucose is not a mechanism that provides ‘energy on demand’ during the physiologic brain activation characterising REM sleep.", journal = "Journal of Cerebral Blood Flow & Metabolism", title = "Sleep-related brain activation does not increase the permeability of the blood–brain barrier to glucose", volume = "25", number = "8", pages = "990-997", doi = "10.1038/sj.jcbfm.9600100" }
Silvani, A., Asti, V., Berteotti, C., Bojić, T., Cianci, T., Ferrari, V., Franzini, C., Lenzi, P.,& Zoccoli, G.. (2005). Sleep-related brain activation does not increase the permeability of the blood–brain barrier to glucose. in Journal of Cerebral Blood Flow & Metabolism, 25(8), 990-997. https://doi.org/10.1038/sj.jcbfm.9600100
Silvani A, Asti V, Berteotti C, Bojić T, Cianci T, Ferrari V, Franzini C, Lenzi P, Zoccoli G. Sleep-related brain activation does not increase the permeability of the blood–brain barrier to glucose. in Journal of Cerebral Blood Flow & Metabolism. 2005;25(8):990-997. doi:10.1038/sj.jcbfm.9600100 .
Silvani, Alessandro, Asti, Valentina, Berteotti, Chiara, Bojić, Tijana, Cianci, Tullia, Ferrari, Vera, Franzini, Carlo, Lenzi, Pierluigi, Zoccoli, Giovanna, "Sleep-related brain activation does not increase the permeability of the blood–brain barrier to glucose" in Journal of Cerebral Blood Flow & Metabolism, 25, no. 8 (2005):990-997, https://doi.org/10.1038/sj.jcbfm.9600100 . .